WO2019230360A1 - Patch adhésif - Google Patents
Patch adhésif Download PDFInfo
- Publication number
- WO2019230360A1 WO2019230360A1 PCT/JP2019/018999 JP2019018999W WO2019230360A1 WO 2019230360 A1 WO2019230360 A1 WO 2019230360A1 JP 2019018999 W JP2019018999 W JP 2019018999W WO 2019230360 A1 WO2019230360 A1 WO 2019230360A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aqueous gel
- patch
- release film
- support substrate
- outer peripheral
- Prior art date
Links
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- 230000001070 adhesive effect Effects 0.000 title abstract description 6
- 239000007933 dermal patch Substances 0.000 title abstract 3
- 239000000758 substrate Substances 0.000 claims description 45
- 230000002093 peripheral effect Effects 0.000 claims description 30
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- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 2
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- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
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- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
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- 235000003421 Plantago ovata Nutrition 0.000 description 1
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- 239000003242 anti bacterial agent Substances 0.000 description 1
- 235000009120 camo Nutrition 0.000 description 1
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- 229960002154 guar gum Drugs 0.000 description 1
- 239000011487 hemp Substances 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
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- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
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- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
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- 235000019477 peppermint oil Nutrition 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
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- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Definitions
- the present invention relates to a patch used by being affixed to human skin.
- Examples of this type of patch include poultices and coolants for fever, headache, toothache, cooling of affected areas during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports.
- a structure in which an aqueous gel 102 is laminated on a support substrate 101 and the aqueous gel 102 is covered with a release film 103 is generally known (for example, patents). Reference 1).
- the release film 103 is detachably attached to the surface of the aqueous gel 102 due to the adhesiveness of the aqueous gel 102, and the end surface of the aqueous gel 102 is exposed. Therefore, when the aqueous gel 102 is pressed by pressing the front surface and / or back surface of the patch 100 during transportation or the like, the aqueous gel 102 may be pushed out and protrude from the outer peripheral edge of the patch 100, This becomes a significant problem when the thickness of the aqueous gel 102 is large or when the water content of the aqueous gel 102 is high and the fluidity is high. In order to solve this problem, a step for promoting the solidification of the aqueous gel 102 is required, which causes an increase in manufacturing cost.
- the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a patch that can prevent the aqueous gel from protruding.
- the patch of the present invention comprises a support substrate, an aqueous gel laminated on one surface of the support substrate, and a release film covering the aqueous gel, and one of the support substrate and the release film.
- An outer peripheral edge is joined to the other of the support substrate and the release film over the entire circumference.
- the outer peripheral edges of the support substrate and the release film are bonded over the entire circumference.
- the water content of the aqueous gel is preferably 65% by weight or more and 90% by weight or less.
- the support substrate is preferably a non-woven fabric.
- the non-woven fabric is made of polyethylene terephthalate resin fiber and the release film is made of polyolefin resin.
- one outer peripheral edge of the support substrate and the release film is bonded to the other over the entire circumference, and the aqueous gel is enclosed in the support substrate and the release film. Therefore, even when the surface and / or back surface of the patch is pressed during transportation or storage of the patch, the aqueous gel is pushed out and protrudes from the outer peripheral edge of the patch. Can be prevented. Moreover, the process for accelerating solidification of aqueous gel at the time of manufacture of a patch can be shortened or abbreviate
- FIG. 2 is a cross-sectional view showing a schematic configuration of a vertical cross section along the line AA in FIG. 1. It is sectional drawing which shows schematic structure of the longitudinal cross-section of the patch of a prior art example.
- the patch of the present invention is used by being affixed to human skin, for example, fever, headache, toothache, cooling of the affected area during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports.
- the sheet-like coolant used for down etc. can be illustrated.
- FIG.1 and FIG.2 shows the patch 1 of this embodiment.
- the patch 1 has at least a support substrate 2, an aqueous gel 3, and a release film 4, and has a layer structure in which these are laminated.
- the patch 1 Prior to use, the patch 1 is stored in a packaging bag (not shown) in a stacked state.
- the patch 1 is taken out from the packaging bag, the release film 4 is peeled off from the support base 2, and then the exposed aqueous gel 3 is directly applied to the site to be cooled of the skin. It is affixed to the user's skin due to its adhesiveness.
- moisture content contained in the aqueous gel 3 evaporates with progress of time, and since the temperature of the aqueous gel 3 falls with the heat of vaporization taken away at that time, the skin which contacts the aqueous gel 3 is cooled.
- the thickness and size of the patch 1 are not particularly limited, and the thickness and size can be appropriately set according to the purpose and the site to be cooled.
- the shape of the patch 1 is not particularly limited, and is a rectangular shape in plan view in the present embodiment, but may be various other shapes such as a square shape, a circular shape, and an elliptical shape.
- the support base material 2 supports the aqueous gel 3 on one surface thereof.
- the support base material 2 is not particularly limited as long as the support base material 2 has moisture permeability and air permeability and can carry the aqueous gel 3, and is formed of various woven fabrics, nonwoven fabrics, films, and the like. can do.
- natural fibers such as cotton, hemp, wool, etc .
- cellulosic fibers such as rayon and acetate
- nylon, vinylon, styrene, polypropylene, polyethylene, polyethylene terephthalate examples thereof include synthetic resin fibers such as acrylic.
- a polystyrene (styrene), a polypropylene, a polyethylene terephthalate, polyethylene etc. can be illustrated.
- the thickness of the support substrate 2 is not particularly limited, but is preferably 0.1 mm or more and 3.0 mm or less, and preferably 0.5 mm or more from the viewpoints of feeling of use, ease of fitting to the pasting site, and the like. More preferably, it is 2.0 mm or less.
- the support base material 2 has an appropriate stretchability so as to fit and adapt to various application sites of the body to be applied.
- the degree of stretchability is not particularly limited, and the stretch direction can be stretched and contracted only in one direction (longitudinal direction) of the support base 2, and only the other upper (width direction) orthogonal to the one direction. It is possible to expand and contract, or it is possible to expand and contract both in one direction (longitudinal direction) and the other direction (width direction), but it is preferable that it can expand and contract in both directions.
- the aqueous gel 3 is formed by laminating on one surface of the support substrate 2.
- various materials that are compatible with the skin can be used.
- the thickness of the aqueous gel 3 is not particularly limited, but is preferably appropriately large from the viewpoints of cooling power, feel when affixed to the skin, maintenance of the affixed state to the skin, and the like.
- the thickness D C of the aqueous gel 3 at the center position of the support substrate 2 is 0.1mm or more 20mm or less, and more preferably less than 1.0mm 10mm or less.
- the thickness of the aqueous gel 3 is preferably uniform or substantially uniform over the entire area of the support substrate 2, and there is no significant difference between the thickness of the aqueous gel 3 in the central portion and the thickness of the aqueous gel 3 in the outer peripheral portion. It is preferable.
- the ratio D E / D C of the thickness D E of 1.0mm inside position of the aqueous gel 3 of the junction 5 of the supporting substrate 2 to the thickness D C of the aqueous gel 3 at the center position of the support substrate 2 is 0. It is preferably 1 or more and 2.0 or less, more preferably 0.3 or more and 1.2 or less, and further preferably 0.5 or more and 1.0 or less.
- the thickness of the aqueous gel 3 can be measured using the method described in “6.1 Thickness (ISO Method)” of JIS L1913: 2010.
- the thickness of the aqueous gel 3 does not necessarily have to be uniform or substantially uniform over the entire area of the support base 2 and gradually decreases or gradually increases toward the outer peripheral edge of the support base 2 or Only the portion close to the outer peripheral edge of the support substrate 2 may gradually decrease or increase gradually toward the outer peripheral edge.
- the aqueous gel 3 has water repellency, moisture release, self-retaining property, adhesiveness and the like.
- Hydrophilic means the property of stably containing water inside, but more preferably means the property of not exuding the contained water even when further compressed.
- Self shape retention means the property of maintaining the shape without causing significant fluidity or disintegration.
- components that can exhibit such properties including water include natural polymer polysaccharides generally used as gelling agents.
- natural gums such as carrageenan, alginic acid, propylene glycol alginate, tara gum, locust bean gum, glucomannan, xanthan gum, gellan gum, pectin, pullulan, guar gum, psyllium gum, sodium alginate, mannan, gelatin, agar Can be illustrated. These can be used alone or in combination of two or more.
- glucomannan and locust bean gum can be exemplified.
- gelling agent examples include polyacrylic acid, polymethacrylic acid, a salt of polyacrylic acid, a salt of polymethacrylic acid, and the like in addition to the natural polymer polysaccharide described above. These can be used alone or in combination of two or more.
- Aqueous gel 3 is a cooling agent such as polyhydric alcohol, surfactant, preservative, preservative, stabilizer, flavor, colorant, pH adjuster, limonene, camphor, peppermint oil or l-menthol as other components. It may contain known additives such as agents, moisturizers, stimulants, disinfectants, antibacterial agents, tackifiers, shape retainers, thickeners and the like.
- the aqueous gel 3 preferably contains a sufficient amount of moisture in order to continuously exhibit a desired cooling power, and the water content of the aqueous gel 3 is in the composition constituting the aqueous gel 3. 60% by weight or more, more preferably 70% by weight or more.
- the upper limit of the water content of the aqueous gel 3 is preferably 95% by weight or less, and more preferably 90% by weight or less, from the viewpoint of self-shape retention.
- the release film 4 covers the aqueous gel 3 before using the patch 1, and the release film 4 can improve the handleability and hygiene of the patch 1.
- the material of the release film 4 is not particularly limited as long as the aqueous gel 3 can be coated.
- Examples of the release film 4 include synthetic resins such as polypropylene, polyethylene, polyester, nylon, vinyl chloride, and polyethylene terephthalate. .
- the support base 2 and the release film 4 have one outer periphery joined to the other over the entire circumference.
- the support base material 2 and the peeling film 4 are the same shape and magnitude
- the aqueous gel 3 is enclosed in the inside of the support base material 2 and the peeling film 4, and the end surface of the aqueous gel 3 is not exposed.
- the shape of the release film 4 is larger than that of the support substrate 2, the outer peripheral edge of the support substrate 2 is joined to the release film 4 over the entire circumference, and the support substrate 2 is more than the release film 4.
- the shape is large, the outer peripheral edge of the release film 4 is bonded to the support substrate 2 over the entire periphery.
- the outer peripheral edge is bonded over the entire circumference means that the outer peripheral edge of the support base (or release film) is bonded to the release film (or the support base) substantially over the entire circumference.
- the outer periphery of the support substrate (or release film) is large.
- the part includes a state in which a part of what is bonded to the release film (or support substrate) is not bonded to the release film (or support substrate).
- the outer periphery of the support substrate (or release film) was joined to the release film (or support substrate) over the entire circumference at the time of manufacture of the patch, but the patch 1 after manufacture was transported or stored. It also includes the case where a part of the outer peripheral edge of the support substrate (or release film) has been disconnected before use.
- the method of joining the support substrate 2 and the release film 4 is not particularly limited as long as it is not bonded via the adhesiveness of the aqueous gel 3.
- the support substrate 2 and the release film 4 are publicly known.
- Various known methods such as a method of welding the release film 4 to the support substrate 2 by applying ultrasonic vibration from the release film 4 side to the outer peripheral edge in the state can be used.
- the patch 1 having the above-described configuration is efficiently cut by cutting a patch sheet in which a plurality of the patch 1 is continuous in at least one direction along a cutting line that divides the patch 1 into individual patches 1.
- the patch sheet is sandwiched between the ultrasonic vibration device and the cutting device, and the horn of the ultrasonic vibration device is brought into contact with the release film 4 in the cutting line of the patch sheet.
- the support substrate 2 and the release film 4 can be joined together with the cutting. Thereby, the manufacturing efficiency of the patch can be further improved.
- the aqueous gel 3 can be cut with high precision without causing the aqueous gel 3 to adhere to the cutting blade and the cut surface is clean.
- the adhesive patch 1 can be produced, and the aqueous gel can be prevented from leaking out from the outer peripheral edge of the adhesive patch 1 during the line conveyance of the adhesive patch 1 after cutting. Therefore, it is preferable to use the method (3) as a method for bonding the support substrate 2 and the release film 4.
- a support group is used. It is preferable that the material 2 is made of a nonwoven fabric made of polyethylene terephthalate resin fibers, and the release film 4 is made of a polyolefin resin such as polypropylene or polyethylene.
- the joint portion 5 of the support substrate 2 and the release film 4 in the patch 1 may have a stripe shape with a small width W or a belt shape with a slightly larger width W, but the width W of the joint portion 5 may be.
- the outer peripheral edge of the support base material 2 adheres well to the skin due to the adhesiveness of the aqueous gel 3, the outer peripheral edge of the support base material 2 becomes difficult to roll up, so that the patch 1 is easily peeled off from the skin. Can be suppressed.
- the width W of the joint portion 5 is preferably 2.0 mm or less, more preferably 1.0 mm or less, and further preferably 0.5 mm or less from the viewpoint described above.
- the lower limit of the width W of the bonding portion 5 is preferably 0.05 mm or more, more preferably 0.1 mm or more, from the viewpoint of bonding strength between the support base 2 and the release film 4. More preferably, it is 2 mm or more.
- the patch 1 of the present embodiment described above since the outer peripheral edges of the support base 2 and the release film 4 are joined over the entire circumference, the surface of the patch 1 during transportation or storage of the patch 1 is used. And even if the back surface is pressed and the aqueous gel 3 is pressed, the aqueous gel 3 can be prevented from being pushed out and protruding from the outer peripheral edge of the patch 1. Thereby, when a user uses the patch 1, it can prevent that the aqueous gel 3 adheres to a user's hand.
- the patch 1 since the patch 1 is stored in a state where a plurality of patches 1 are stacked in a packaging box (not shown) at the time of transportation or storage, the patch 1 has the weight of other patches 1.
- the aqueous gel 3 By receiving, the aqueous gel 3 is pressed. Conventionally, since the aqueous gel 3 may be pressed out from the outer peripheral edge of the patch 1, a partition is set in the packaging box, and the aqueous gel 3 receives the weight of the patch 1 in the partition. Was prevented from being pressed.
- the patch 1 of the present embodiment has a medium inside because the aqueous gel 3 does not protrude from the outer peripheral edge of the patch 1 even if the aqueous gel 3 is compressed by the weight of the other patches 1 in the packaging box. No partition is required, and the cost can be reduced accordingly.
- the patch 1 of this embodiment does not leak from the outer peripheral edge of the patch 1 even if the water content of the aqueous gel 3 is high and the fluidity is high. Therefore, conventionally, at the time of manufacture of the patch, a treatment for solidifying the aqueous gel 3 after cutting the patch sheet into individual patches 1 was necessary. According to this, since this processing step is unnecessary or the processing time can be shortened, the manufacturing efficiency of the patch can be improved by shortening the processing time.
- the patch 1 of this embodiment suppresses that the outer peripheral edge of the release film 4 is rolled up and easily peeled off from the support base material 2. can do. Thereby, since the aqueous gel 3 is continuously enclosed in the inside of the support base material 2 and the peeling film 4, the drying of the aqueous gel 3 etc. can be prevented.
- the support base material 2 and the peeling film 4 are the same shapes, if one outer periphery of the support base material 2 and the peeling film 4 is joined to the other over the perimeter, a support base material 2 and the release film 4 may have different shapes.
- the patch 1 has a three-layer structure of the support base 2, the aqueous gel 3, and the release film 4, but may have other layers.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention fournit un patch adhésif permettant d'empêcher le débordement d'un gel aqueux. Plus spécifiquement, un patch adhésif (1) comporte: une base support (2); un gel aqueux (3) stratifié sur une face de la base support (2); et un film (4) pouvant être retiré qui recouvre le gel aqueux (3). Les bords externes de la base support (2) et du film (4) pouvant être retiré sont collés sur tout leur contour.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018-105498 | 2018-05-31 | ||
JP2018105498A JP2019208688A (ja) | 2018-05-31 | 2018-05-31 | 貼付剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2019230360A1 true WO2019230360A1 (fr) | 2019-12-05 |
Family
ID=68698618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2019/018999 WO2019230360A1 (fr) | 2018-05-31 | 2019-05-13 | Patch adhésif |
Country Status (3)
Country | Link |
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JP (1) | JP2019208688A (fr) |
TW (1) | TW202002951A (fr) |
WO (1) | WO2019230360A1 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61215321A (ja) * | 1985-03-18 | 1986-09-25 | メンレイ・アンド・ジエームス・ラボラトリース・リミテツド | 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法 |
JPH06296702A (ja) * | 1992-04-21 | 1994-10-25 | Mli Acquisition Corp Ii | ヒドロゲルアプリケータおよびその製造方法 |
JP2003019157A (ja) * | 2001-07-06 | 2003-01-21 | Advance Co Ltd | 温感材並びに冷感材 |
JP2003102760A (ja) * | 2001-09-28 | 2003-04-08 | Toko Yakuhin Kogyo Kk | 貼付材及びその製造方法 |
-
2018
- 2018-05-31 JP JP2018105498A patent/JP2019208688A/ja active Pending
-
2019
- 2019-05-02 TW TW108115183A patent/TW202002951A/zh unknown
- 2019-05-13 WO PCT/JP2019/018999 patent/WO2019230360A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61215321A (ja) * | 1985-03-18 | 1986-09-25 | メンレイ・アンド・ジエームス・ラボラトリース・リミテツド | 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法 |
JPH06296702A (ja) * | 1992-04-21 | 1994-10-25 | Mli Acquisition Corp Ii | ヒドロゲルアプリケータおよびその製造方法 |
JP2003019157A (ja) * | 2001-07-06 | 2003-01-21 | Advance Co Ltd | 温感材並びに冷感材 |
JP2003102760A (ja) * | 2001-09-28 | 2003-04-08 | Toko Yakuhin Kogyo Kk | 貼付材及びその製造方法 |
Also Published As
Publication number | Publication date |
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TW202002951A (zh) | 2020-01-16 |
JP2019208688A (ja) | 2019-12-12 |
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