WO2019230362A1 - Patch adhésif - Google Patents

Patch adhésif Download PDF

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Publication number
WO2019230362A1
WO2019230362A1 PCT/JP2019/019001 JP2019019001W WO2019230362A1 WO 2019230362 A1 WO2019230362 A1 WO 2019230362A1 JP 2019019001 W JP2019019001 W JP 2019019001W WO 2019230362 A1 WO2019230362 A1 WO 2019230362A1
Authority
WO
WIPO (PCT)
Prior art keywords
aqueous gel
patch
release film
base material
support base
Prior art date
Application number
PCT/JP2019/019001
Other languages
English (en)
Japanese (ja)
Inventor
直礼 奥田
裕樹 堀本
立樹 小枝
彰 永松
Original Assignee
小林製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 小林製薬株式会社 filed Critical 小林製薬株式会社
Publication of WO2019230362A1 publication Critical patent/WO2019230362A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a patch used by being affixed to human skin.
  • Examples of this type of patch include poultices and coolants for fever, headache, toothache, cooling of affected areas during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports.
  • a structure in which an aqueous gel 102 is laminated on a support base 101 and the aqueous gel 102 is covered with a release film 103 is generally known.
  • this conventional patch 100 is a band-shaped patch sheet in which an aqueous gel is applied onto a long support substrate and then a long release film is superimposed on the surface thereof. It is manufactured by cutting into a predetermined size with a cutting blade.
  • the cutting position of the patch sheet is pressed to extrude and eliminate the aqueous gel at the cutting position. It is carried out. This prevents the aqueous gel from being exposed on the end face (cut face) of the cut patch.
  • the aqueous gel 102 does not exist in the vicinity of the outer periphery due to the above-described creasing. Therefore, as shown in FIG. 5, the patch 100 is attached to the user's skin S due to the adhesiveness of the aqueous gel 102, but when the aqueous gel 102 does not exist in the vicinity of the outer periphery, The outer peripheral edge of the support substrate 101 is rolled up, and the patch 100 is easily peeled off from the skin S.
  • the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a patch that does not easily peel from the skin.
  • the patch of the present invention comprises a support substrate, an aqueous gel laminated on one surface of the support substrate, and a release film covering the aqueous gel, and one of the support substrate and the release film. At least a part of the outer peripheral edge is joined to the other of the support substrate and the release film, and the aqueous gel has a thickness of the aqueous gel at least at a part of the support base and the release film on the joining part side. It is characterized by becoming gradually smaller toward the joint.
  • the support substrate and the release film preferably have a rectangular shape in plan view, and a pair of opposing sides are preferably joined to each other.
  • the water content of the aqueous gel is preferably 65% by weight or more and 90% by weight or less.
  • the support substrate is preferably a non-woven fabric.
  • the non-woven fabric is made of polyethylene terephthalate resin fiber and the release film is made of polyolefin resin.
  • the outer peripheral edges of the support substrate and the release film are joined over the entire circumference.
  • the aqueous gel has a thickness of the aqueous gel bonded in the vicinity of the bonded part. It gradually gets smaller as you head to the club. Therefore, when the adhesive film is applied by applying the exposed aqueous gel to the user's skin after peeling off the release film, the support base material is wrapped around the aqueous gel at the outer peripheral edge of the adhesive, and is supported. The base material adheres to the skin due to the adhesiveness of the aqueous gel in a state where the outer peripheral edge of the base material does not float from the user's skin. Therefore, since it can suppress that the outer periphery of a support base material rolls up, a patch can be made hard to peel from skin.
  • FIG. 2 is a cross-sectional view showing a schematic configuration of a vertical cross section along the line AA in FIG. 1. It is explanatory drawing which shows a state when a patch is affixed on skin. It is sectional drawing which shows schematic structure of the longitudinal cross-section of the patch of a prior art example. It is explanatory drawing which shows a state when the patch of a prior art example is affixed on skin.
  • the patch of the present invention is used by being affixed to human skin, for example, fever, headache, toothache, cooling of the affected area during inflammation, cooling of hot flashes on the face, etc., and cooling of muscles after sports.
  • the sheet-like coolant used for down etc. can be illustrated.
  • FIG.1 and FIG.2 shows the patch 1 of this embodiment.
  • the patch 1 has at least a support substrate 2, an aqueous gel 3, and a release film 4, and has a layer structure in which these are laminated.
  • the patch 1 Prior to use, the patch 1 is stored in a packaging bag (not shown) in a stacked state.
  • the patch 1 is taken out from the packaging bag, the release film 4 is peeled off from the support base 2, and then the exposed aqueous gel 3 is directly applied to the site to be cooled of the skin. It is affixed to the user's skin due to its adhesiveness.
  • moisture content contained in the aqueous gel 3 evaporates with progress of time, and since the temperature of the aqueous gel 3 falls with the heat of vaporization taken away at that time, the skin which contacts the aqueous gel 3 is cooled.
  • the thickness and size of the patch 1 are not particularly limited, and the thickness and size can be appropriately set according to the purpose and the site to be cooled.
  • the external shape of the patch 1 is not particularly limited, and is rectangular in plan view in the present embodiment, but may be various other shapes such as a square shape, a circular shape, and an elliptical shape.
  • the support base material 2 supports the aqueous gel 3 on one surface thereof.
  • the support base material 2 is not particularly limited as long as the support base material 2 has moisture permeability and air permeability and can carry the aqueous gel 3, and is formed of various woven fabrics, nonwoven fabrics, films, and the like. can do.
  • natural fibers such as cotton, hemp, wool, etc .
  • cellulosic fibers such as rayon and acetate
  • nylon, vinylon, styrene, polypropylene, polyethylene, polyethylene terephthalate examples thereof include synthetic resin fibers such as acrylic.
  • a polystyrene (styrene), a polypropylene, a polyethylene terephthalate, polyethylene etc. can be illustrated.
  • the thickness of the support substrate 2 is not particularly limited, but is preferably 0.1 mm or more and 3.0 mm or less, and preferably 0.5 mm or more from the viewpoints of feeling of use, ease of fitting to the pasting site, and the like. More preferably, it is 2.0 mm or less.
  • the support base material 2 has an appropriate stretchability so as to fit and adapt to various application sites of the body to be applied.
  • the degree of stretchability is not particularly limited, and the stretch direction can be stretched and contracted only in one direction (longitudinal direction) of the support base 2, and only the other upper (width direction) orthogonal to the one direction. It is possible to expand and contract, or it is possible to expand and contract both in one direction (longitudinal direction) and the other direction (width direction), but it is preferable that it can expand and contract in both directions.
  • the aqueous gel 3 is formed by laminating on one surface of the support substrate 2.
  • various materials that are compatible with the skin can be used.
  • the thickness of the aqueous gel 3 is not particularly limited, but is preferably appropriately large from the viewpoints of cooling power, feel when affixed to the skin, maintenance of the affixed state to the skin, and the like.
  • the thickness D C is 0.1mm or more 20mm or less at the center position of the support substrate 2, and more preferably less than 1.0mm 10mm or less.
  • the thickness of the aqueous gel 3 can be measured using the method described in “6.1 Thickness (ISO Method)” of JIS L1913: 2010.
  • the thickness of the aqueous gel 3 is at least a portion close to the outer peripheral edge of the support base 2 (a part on the side of the joint 5 where the release film 4 is joined to the support base 2 described later). It gradually becomes smaller toward the periphery (joint part 5). That is, the aqueous gel 3 has a tapered outer peripheral edge portion in the vicinity of the joint portion 5 in the longitudinal sectional view. If the thickness of the aqueous gel 3 is gradually reduced toward the joint part 5 at least at a part on the joint part 5 side, as shown in FIG.
  • It may have a shape that protrudes in a dome shape toward the surface, and although it is not illustrated, it may have a shape in which the central portion protrudes toward the release film 4 in a substantially trapezoidal shape that is flat or substantially flat. Further, it may have a dome shape or a substantially trapezoidal shape rising toward the support base material side 2, and further, a dome shape or a substantially base shape toward the support base material side 2 and the release film 4 side. The shape which protrudes in the shape may be exhibited.
  • the aqueous gel 3 has water hydration property, moisture release property, self-retaining property or adhesiveness.
  • Hydrophilic means the property of stably containing water inside, but more preferably means the property of not exuding the contained water even when further compressed.
  • Self shape retention means the property of maintaining the shape without causing significant fluidity or disintegration.
  • components that can exhibit such properties including water include natural polymer polysaccharides generally used as gelling agents.
  • natural gums such as carrageenan, alginic acid, propylene glycol alginate, tara gum, locust bean gum, glucomannan, xanthan gum, gellan gum, pectin, pullulan, guar gum, psyllium gum, sodium alginate, mannan, gelatin, agar Can be illustrated. These can be used alone or in combination of two or more.
  • glucomannan and locust bean gum can be exemplified.
  • gelling agent examples include polyacrylic acid, polymethacrylic acid, a salt of polyacrylic acid, a salt of polymethacrylic acid, and the like in addition to the natural polymer polysaccharide described above. These can be used alone or in combination of two or more.
  • Aqueous gel 3 is a cooling agent such as polyhydric alcohol, surfactant, preservative, preservative, stabilizer, flavor, colorant, pH adjuster, limonene, camphor, peppermint oil or l-menthol as other components. It may contain known additives such as agents, moisturizers, stimulants, disinfectants, antibacterial agents, tackifiers, shape retainers, thickeners and the like.
  • the aqueous gel 3 preferably contains a sufficient amount of moisture in order to continuously exhibit a desired cooling power, and the water content of the aqueous gel 3 is in the composition constituting the aqueous gel 3. 60% by weight or more, more preferably 70% by weight or more.
  • the upper limit of the water content of the aqueous gel 3 is preferably 95% by weight or less, and more preferably 90% by weight or less, from the viewpoint of self-shape retention.
  • the release film 4 covers the aqueous gel 3 before using the patch 1, and the release film 4 can improve the handleability and hygiene of the patch 1.
  • the material of the release film 4 is not particularly limited as long as the aqueous gel 3 can be coated.
  • Examples of the release film 4 include synthetic resins such as polypropylene, polyethylene, polyester, nylon, vinyl chloride, and polyethylene terephthalate. .
  • a part of one outer peripheral edge of the support base 2 and the release film 4 are joined to the other. Specifically, when the support substrate 2 and the release film 4 have the same shape and size, a part of the outer peripheral edge is joined.
  • the release film 4 is larger in shape than the support substrate 2
  • a part of the outer peripheral edge of the support substrate 2 is joined to the release film 4
  • the support substrate 2 is larger in shape than the release film 4.
  • a part of the outer peripheral edge of the release film 4 is bonded to the support base material 2.
  • the outer periphery of the support base material 2 and the peeling film 4 is joined over the perimeter, Therefore, the aqueous gel 3 is enclosed with the inside of the support base material 2 and the peeling film 4, and an aqueous gel The end face of 3 is not exposed.
  • “the outer peripheral edge is bonded over the entire circumference” means that the outer peripheral edge of the support substrate (or the release film) is bonded to the release film (or the support base material) over the entire circumference. In addition to the state in which the entire outer periphery of the support substrate (or release film) is bonded to the release film (or support substrate), most of the outer periphery of the support substrate (or release film) is peeled off.
  • a state in which a part of what is bonded to the film (or the supporting substrate) is not bonded to the release film (or the supporting substrate) is also included. That is, the outer periphery of the support substrate (or release film) was joined to the release film (or support substrate) over the entire circumference at the time of manufacture of the patch, but the patch 1 after manufacture was transported or stored. It also includes the case where a part of the outer peripheral edge of the support substrate (or release film) has been disconnected before use.
  • the method of joining the support substrate 2 and the release film 4 is not particularly limited as long as it is not bonded via the adhesiveness of the aqueous gel 3.
  • the support substrate 2 and the release film 4 are publicly known.
  • Various known methods such as a method of welding the release film 4 to the support substrate 2 by applying ultrasonic vibration from the release film 4 side to the outer peripheral edge in the state can be used.
  • the patch 1 having the above-described configuration is efficiently cut by cutting a patch sheet in which a plurality of the patch 1 is continuous in at least one direction along a cutting line that divides the patch 1 into individual patches 1.
  • the patch sheet is sandwiched between the ultrasonic vibration device and the cutting device, and the horn of the ultrasonic vibration device is brought into contact with the release film 4 in the cutting line of the patch sheet.
  • the support substrate 2 and the release film 4 can be joined together with the cutting. Thereby, the manufacturing efficiency of the patch can be further improved.
  • the aqueous gel 3 can be cut with high precision without causing the aqueous gel 3 to adhere to the cutting blade and the cut surface is clean.
  • the adhesive patch 1 can be produced, and the aqueous gel can be prevented from leaking out from the outer peripheral edge of the adhesive patch 1 during the line conveyance of the adhesive patch 1 after cutting. Therefore, it is preferable to use the method (3) as a method for bonding the support substrate 2 and the release film 4.
  • a support group is used. It is preferable that the material 2 is made of a nonwoven fabric made of polyethylene terephthalate resin fibers, and the release film 4 is made of a polyolefin resin such as polypropylene or polyethylene.
  • the joint portion 5 of the support substrate 2 and the release film 4 in the patch 1 may have a stripe shape with a small width W or a belt shape with a slightly larger width W, but the width W of the joint portion 5 may be.
  • the width W of the joint portion 5 is preferably 2.0 mm or less, more preferably 1.0 mm or less, and further preferably 0.5 mm or less from the viewpoint described above.
  • the lower limit of the width W of the bonding portion 5 is preferably 0.05 mm or more, more preferably 0.1 mm or more, from the viewpoint of bonding strength between the support base 2 and the release film 4. More preferably, it is 2 mm or more.
  • the aqueous gel 3 is aqueous in the vicinity of the bonded portion 5.
  • the thickness of the gel 3 gradually decreases as it goes toward the joint 5. Therefore, as shown in FIG. 3 (A), the aqueous gel 3 exposed by peeling off the release film 4 is applied to the skin S of the user, and then the support substrate 2 is aqueous as shown in FIG. 3 (B).
  • the support base 2 is wrapped around the aqueous gel 3 at the outer peripheral edge of the patch 1, and the outer peripheral edge of the support base 2 is the user's skin.
  • the patch 1 can be made hard to peel from skin.
  • the outer periphery of the support base material 2 and the peeling film 4 is joined over the perimeter, since the perimeter of the outer periphery of the support base material 2 becomes difficult to roll up, it makes it difficult to peel the patch 1 from the skin further. be able to.
  • the patch 1 of this embodiment has joined at least one part of the outer periphery of the support base material 2 and the peeling film 4, the outer periphery of the peeling film 4 rolls up easily from the support base material 2. It can suppress peeling.
  • the surface and / or the back surface of the patch 1 is pressed at the time of transportation or storage, etc. Even if it is pressed, it is possible to prevent the aqueous gel 3 from being pushed out and protruding from the outer peripheral edge of the patch 1. Thereby, when a user uses the patch 1, it can prevent that the aqueous gel 3 adheres to a user's hand.
  • the patch 1 is stored in a state where a plurality of patches 1 are stacked in a packaging box (not shown) at the time of transportation, storage, etc.
  • the patches 1 are weights of other patches 1.
  • the aqueous gel 3 is compressed.
  • the patch 1 of the present embodiment has a medium inside because the aqueous gel 3 does not protrude from the outer peripheral edge of the patch 1 even if the aqueous gel 3 is compressed by the weight of the other patches 1 in the packaging box. No partition is required, and the cost can be reduced accordingly.
  • the aqueous gel 3 does not leak from the outer peripheral edge of the patch 1. Therefore, conventionally, at the time of manufacturing the patch, a treatment for solidifying the aqueous gel 3 after cutting the patch sheet into individual patches was necessary.
  • this processing step is unnecessary or the processing time can be shortened, the manufacturing efficiency of the patch can be improved by shortening the processing time.
  • the support base material 2 and the peeling film 4 have one outer periphery joined to the other over the perimeter, even if only a part of one outer periphery is joined to the peeling film 4 Good.
  • the support base material 2 and the release film 4 have a rectangular shape in plan view (including a square shape and a rectangular shape), a pair of opposing sides of the support base material 2 and the release film 4 are joined at least. Just do it.
  • a support base material 2 and the peeling film 4 are the same shapes, if at least one part of one outer periphery of the support base material 2 and the peeling film 4 is joined to the other, a support base material 2 and the release film 4 may have different shapes.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

L'invention fournit un patch adhésif qui se décolle difficilement de la peau. Plus spécifiquement, un patch adhésif (1) comporte: une base support (2); un gel aqueux (3) stratifié sur une face de la base support (2); et un film (4) pouvant être retiré qui recouvre le gel aqueux (3). Les bords externes de la base support (2) et du film (4) pouvant être retiré sont collés sur tout leur contour. L'épaisseur du gel aqueux (3), du moins au niveau d'une partie côté partie collée (5) de la base support (2) et du film (4) pouvant être retiré, va en diminuant peu à peu en direction de la partie collée (5).
PCT/JP2019/019001 2018-05-31 2019-05-13 Patch adhésif WO2019230362A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-105550 2018-05-31
JP2018105550A JP2019208691A (ja) 2018-05-31 2018-05-31 貼付剤

Publications (1)

Publication Number Publication Date
WO2019230362A1 true WO2019230362A1 (fr) 2019-12-05

Family

ID=68697507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2019/019001 WO2019230362A1 (fr) 2018-05-31 2019-05-13 Patch adhésif

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Country Link
JP (1) JP2019208691A (fr)
TW (1) TWI787506B (fr)
WO (1) WO2019230362A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021106210A1 (fr) * 2019-11-29 2021-06-03 小林製薬株式会社 Timbre transdermique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61215321A (ja) * 1985-03-18 1986-09-25 メンレイ・アンド・ジエームス・ラボラトリース・リミテツド 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法
JPH06296702A (ja) * 1992-04-21 1994-10-25 Mli Acquisition Corp Ii ヒドロゲルアプリケータおよびその製造方法
JP2003019157A (ja) * 2001-07-06 2003-01-21 Advance Co Ltd 温感材並びに冷感材
JP2003102760A (ja) * 2001-09-28 2003-04-08 Toko Yakuhin Kogyo Kk 貼付材及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000139986A (ja) * 1998-11-06 2000-05-23 Pigeon Corp 冷却ゲルシート
JP2003199781A (ja) * 2001-10-24 2003-07-15 Daiya Seiyaku Kk パッド材及び携帯用パッド材
JP5226948B2 (ja) * 2006-12-14 2013-07-03 花王株式会社 積層シート及び身体貼付用シート

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61215321A (ja) * 1985-03-18 1986-09-25 メンレイ・アンド・ジエームス・ラボラトリース・リミテツド 局所薬および全身薬の経皮デリバリー制御組成物および該制御方法
JPH06296702A (ja) * 1992-04-21 1994-10-25 Mli Acquisition Corp Ii ヒドロゲルアプリケータおよびその製造方法
JP2003019157A (ja) * 2001-07-06 2003-01-21 Advance Co Ltd 温感材並びに冷感材
JP2003102760A (ja) * 2001-09-28 2003-04-08 Toko Yakuhin Kogyo Kk 貼付材及びその製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021106210A1 (fr) * 2019-11-29 2021-06-03 小林製薬株式会社 Timbre transdermique

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Publication number Publication date
JP2019208691A (ja) 2019-12-12
TWI787506B (zh) 2022-12-21
TW202011913A (zh) 2020-04-01

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