WO2021014440A2 - Contraction of an annuloplasty structure - Google Patents

Contraction of an annuloplasty structure Download PDF

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Publication number
WO2021014440A2
WO2021014440A2 PCT/IL2020/050808 IL2020050808W WO2021014440A2 WO 2021014440 A2 WO2021014440 A2 WO 2021014440A2 IL 2020050808 W IL2020050808 W IL 2020050808W WO 2021014440 A2 WO2021014440 A2 WO 2021014440A2
Authority
WO
WIPO (PCT)
Prior art keywords
sleeve
lumen
anchor
contraction
tool
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2020/050808
Other languages
English (en)
French (fr)
Other versions
WO2021014440A3 (en
Inventor
Assaf SHARON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valtech Cardio Ltd
Original Assignee
Valtech Cardio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valtech Cardio Ltd filed Critical Valtech Cardio Ltd
Priority to JP2021575007A priority Critical patent/JP7592647B2/ja
Priority to EP20754396.8A priority patent/EP4003231B1/en
Priority to CN202080046078.0A priority patent/CN114072101A/zh
Priority to CA3141295A priority patent/CA3141295A1/en
Publication of WO2021014440A2 publication Critical patent/WO2021014440A2/en
Publication of WO2021014440A3 publication Critical patent/WO2021014440A3/en
Priority to US17/581,821 priority patent/US12502277B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0649—Coils or spirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes

Definitions

  • Ischemic heart disease can cause atrioventricular valve regurgitation by, for example, the combination of ischemic dysfunction of the papillary muscles, and the dilatation of the ventricle associated with ischemic heart disease, with the subsequent displacement of the papillary muscles and/or the dilatation of the valve annulus.
  • Dilation of the annulus of an atrioventricular valve can prevent the valve leaflets from fully coapting when the valve is closed. Regurgitation of blood from the ventricle into the atrium can result in increased total stroke volume and decreased cardiac output, and ultimate weakening of the ventricle secondary to a volume overload and a pressure overload of the atrium.
  • Annuloplasty such as by implantation of an annuloplasty ring, can be used to improve leaflet coaptation by adjusting the shape of the atrioventricular valve annulus.
  • Percutaneous (e.g., transfemoral, transseptal, etc.) annuloplasty devices can be beneficial.
  • An adjustable annuloplasty structure comprising a sleeve and a contracting member (e.g., a contraction wire, etc.), is contracted by tensioning the contracting member.
  • a contracting member e.g., a contraction wire, etc.
  • the resulting excess of the contraction member is deposited within the lumen of the sleeve, obviating the need to remove the excess from the implant, e.g., by cutting.
  • Contraction of the annuloplasty structure can therefore achieved by pulling the contraction member into and/or increasing a longitudinal proportion of the contraction member that is disposed within the lumen.
  • the contraction can be maintained by locking a locking mechanism to the contraction member.
  • the contraction member is pulled into the lumen from within the lumen.
  • a system and/or an apparatus for use at a heart of a subject including an annuloplasty structure that includes a flexible sleeve having a first sleeve -end-portion, a second sleeve -end- portion, and a circumferential wall that defines a longitudinal lumen between the first and second sleeve -end-portions.
  • the annuloplasty structure can also include an elongate contraction member, such as a contraction wire.
  • the contraction member/wire having a first end (e.g., a first wire -end) and a second end (e.g., a second wire-end).
  • the first end or wire -end can be attached to the sleeve at the first sleeve-end-portion, and the member/wire extending, in association with the circumferential wall, from the first sleeve -end-portion toward the second sleeve -end-portion.
  • the system/apparatus can also include a plurality of tissue anchors that are configured to anchor the sleeve to tissue.
  • the plurality of tissue anchors can include at least one second sleeve-end-portion tissue anchor configured to anchor the second sleeve-end-portion to tissue by being driven through the circumferential wall and into the tissue.
  • the system/apparatus also includes a force -distributing element configured to surround a second end portion or second wire-end portion of the member/wire that is disposed within the lumen of the sleeve and to distribute a force applied to the at least one second sleeve-end-portion tissue anchor during application of a contraction force to the elongate contraction member/wire.
  • the member/wire is arranged with respect to the sleeve such that increasing a longitudinal proportion of the member/wire that is disposed within the lumen longitudinally contracts the sleeve.
  • the force-distributing element includes a tube shaped so as to define a plurality of slits, and the plurality of slits increase flexibility of the force -distributing element.
  • the force -distributing element includes a flexible coil.
  • each tissue anchor of the plurality of tissue anchors is independently advanceable into the lumen of the sleeve and configured to anchor the sleeve to tissue by being driven through the circumferential wall and into the tissue.
  • the at least one second sleeve -end-portion tissue anchor are configured to anchor the second sleeve-end-portion at a portion of the second sleeve -end-portion containing the second end portion or second wire -end portion of the member/wire that is disposed within the lumen of the sleeve.
  • the member/wire extends from the first sleeve-end-portion to the second sleeve-end-portion in association with the circumferential wall, by weaving along the circumferential wall between the first sleeve-end-portion and the second sleeve -end-portion.
  • the second end portion or second wire-end portion of the member/wire enters the lumen of the sleeve such that it is disposed within the second sleeve -end- portion at an entry point, and the at least one second sleeve-end-portion tissue anchor is anchorable proximally to the entry point.
  • the second end or second wire-end is disposed within the lumen of the sleeve, and the member/wire is arranged with respect to the sleeve such that movement of the second end or second wire-end toward the second sleeve-end-portion increases the longitudinal proportion of the member/wire that is disposed within the lumen of the sleeve by drawing the member/wire into the lumen of the sleeve.
  • the member/wire extends from the first sleeve-end-portion to the second sleeve-end-portion in association with the circumferential wall, by weaving along the circumferential wall between the first sleeve-end-portion and the second sleeve -end-portion.
  • system/apparatus further includes an anchor-delivery tool including an anchor-delivery channel and an anchor driver slidable within the anchor delivery channel.
  • the system/apparatus further includes coupling elements coupled to a distal end of the anchor-delivery tool, and the coupling elements are configured to ensnare a proximal end of the sleeve and have a tendency to flex inwardly toward a central longitudinal axis of the anchor-delivery tool in an absence of force applied thereto.
  • the channel is configured to (a) maintain coupling of the coupling elements to the sleeve by pushing against the coupling elements sleeve of the annuloplasty structure, and (b) facilitate decoupling of the anchor-delivery tool from the annuloplasty structure by being removed from the lumen of the sleeve and allowing the coupling elements to flex inwardly and become decoupled from the sleeve.
  • each anchor of the plurality of tissue anchors is a first anchor of the plurality of tissue anchors:
  • the anchor driver being independently advanceable into the lumen of the sleeve by the anchor driver, and being configured to anchor the sleeve to tissue by the tissue -engaging element being driven through the circumferential wall and into the tissue while the anchor head remains in the lumen of the sleeve;
  • the anchor driver is removable from within a lumen of the channel following anchoring of the sleeve using the plurality of tissue anchors.
  • system/apparatus further includes a contraction tool that includes a contraction member-engaging element or wire-engaging element, and the engaging element, subsequently to the anchoring of the sleeve using the plurality of tissue anchors:
  • a snare configured to ensnare the second end of the member or second wire-end of the wire
  • the system/apparatus further includes a loop coupled to the second end of the member or the second wire -end of the wire and disposed within the second sleeve -end-portion, and the loop surrounds an end portion of the channel that is advanceable within the lumen of the sleeve, and the channel is slidable with respect to the loop while the loop remains disposed within the second sleeve -end-portion, in order to facilitate implantation of the plurality of tissue anchors.
  • the snare is configured to ensnare the loop and to pull the loop into the lumen of the channel in order to facilitate application of a contraction force to the contraction member/wire, and the loop is compressible into the lumen of the channel as the snare pulls the loop and a portion of the contraction member/wire through the lumen of the channel.
  • system/apparatus further includes a closure mechanism at the second sleeve -end-portion, the closure mechanism being maintainable in an opened state while the channel passes through the closure mechanism.
  • the channel is slidable with respect to the loop to and to the closure mechanism in order to facilitate implantation of the plurality of tissue anchors.
  • system/apparatus further includes a contraction tool that includes a contraction member-engaging element or wire-engaging element, and the engaging element:
  • system/apparatus further includes a locking mechanism that has:
  • the locking mechanism is positionable inside the lumen of the sleeve.
  • system/apparatus further includes a contraction tool that includes a contraction member-engaging element or wire -engaging element, and:
  • system/apparatus further includes a lock tool that engages the locking mechanism and is configured to transition the locking mechanism into the locked state.
  • the locking mechanism is biased to assume the locked state
  • the lock tool is configured to retain the locking mechanism in the unlocked state while the lock tool is engaged with the locking mechanism
  • the lock tool is configured to transition the locking mechanism into the locked state by disengaging from the locking mechanism
  • a method including using a delivery tool, securing an annuloplasty structure on an annulus of a valve of a subject.
  • the annuloplasty structure can be the same as or similar to other annuloplasty structures herein or otherwise known.
  • the annuloplasty structure includes (i) a flexible sleeve that defines a longitudinal lumen therethrough, and (ii) an elongate contraction member (e.g., a contraction wire, etc.).
  • the method further includes, subsequently, while the delivery tool is coupled to the annuloplasty structure, longitudinally contracting the sleeve.
  • the sleeve can be contracted in a variety of ways. In some applications, the sleeve is contracted by increasing a longitudinal proportion of the contraction member/wire that is disposed within the lumen or causing the contraction member/wire to enter the lumen, e.g., by drawing the contraction member/wire into the lumen.
  • the delivery tool is coupled to the annuloplasty structure at a proximal end thereof, and longitudinally contracting includes longitudinally pulling the contraction member/wire proximally.
  • the sleeve includes a circumferential wall that defines the lumen, and securing the annuloplasty structure on the annulus includes sequentially, for each anchor of a plurality of anchors:
  • the method further includes, subsequently to the step of longitudinally contracting the sleeve, maintaining a contraction state of the sleeve by locking a locking mechanism to the contraction member/wire.
  • locking the locking mechanism includes locking the locking mechanism while maintaining coupling of the delivery tool to the annuloplasty structure.
  • the method further includes, prior to the locking, delivering a force-distributing element within the lumen of the sleeve and facilitating distributing of contraction forces along the annuloplasty structure using the force-distributing element.
  • securing the annuloplasty structure includes implanting a plurality of tissue anchors, and delivering the force -distributing element includes distributing the contraction forces along a subset of the plurality of tissue anchors.
  • locking the locking mechanism includes locking in place the force-distributing element.
  • the contraction member/wire is coupled to a loop and the loop surrounds a portion of the delivery tool during the securing of the annuloplasty structure on the annulus.
  • longitudinally contracting includes:
  • securing the annuloplasty structure on the annulus includes: advancing the portion of the delivery tool through the lumen of the sleeve while the loop surrounds the portion of the delivery tool,
  • advancing the portion of the delivery tool through the lumen of the sleeve includes moving the portion of the delivery tool with respect to the loop, while the loop remains stationary.
  • advancing the portion of the delivery tool through the lumen of the sleeve includes advancing the portion of the delivery tool distally through the lumen, and driving each one of the plurality of tissue anchors through the respective portions of the sleeve includes retracting the portion of the delivery tool proximally with each successive driving.
  • a portion of the delivery tool slides within the lumen of the sleeve, and the method further includes maintaining coupling of the delivery tool to annuloplasty structure by maintaining the portion of the delivery tool within the lumen.
  • maintaining the coupling of the delivery tool includes pushing outwardly coupling elements of the delivery tool that are coupled to the sleeve of the annuloplasty structure, and the method further includes decoupling the delivery tool from the annuloplasty structure by removing the portion of the delivery tool from within the lumen and allowing the coupling elements to flex inwardly and disengage from the sleeve of the annuloplasty structure.
  • maintaining the coupling of the delivery tool includes maintaining a closure mechanism of the annuloplasty structure in an open state by maintaining the portion of delivery tool within the lumen.
  • the method further includes decoupling the delivery tool from the annuloplasty structure by removing the portion of the delivery tool from within the lumen and transitioning the closure mechanism to a closed state.
  • This method can be performed on a living animal or on a simulation, such as on a cadaver, cadaver heart, simulator (e.g. with the body parts, tissue, etc. being simulated), etc.
  • a system and/or an apparatus for use at a heart of a subject including an annuloplasty structure that includes a flexible sleeve having a first sleeve -end-portion, a second sleeve -end- portion, and a circumferential wall that defines a longitudinal lumen between the first and second sleeve -end-portions.
  • the annuloplasty structure also includes an elongate contraction member/wire having a first end (e.g., a first wire-end) and a second end (e.g., a second wire-end).
  • the first end or first wire -end can be attached to the sleeve at the first sleeve-end-portion with the member/wire extending, in association with the circumferential wall, from the first sleeve -end- portion toward the second sleeve-end-portion.
  • the system/apparatus also includes a plurality of tissue anchors configured to anchor the sleeve to tissue.
  • the plurality of tissue anchors can include at least one second sleeve-end-portion tissue anchor configured to anchor the second sleeve -end- portion to tissue by being driven through the circumferential wall and into the tissue.
  • the system/apparatus also includes an anchor-delivery tool including an anchor-delivery channel and an anchor driver slidable within the anchor delivery channel.
  • a loop is coupled to the second end of the member or the second wire-end of the wire and disposed within the second sleeve -end-portion.
  • the loop can surround an end portion of the channel that is advanceable within the lumen of the sleeve, the channel being slidable with respect to the loop while the loop remains disposed within the second sleeve -end-portion, in order to facilitate implantation of the plurality of tissue anchors.
  • the member/wire is arranged with respect to the sleeve such that increasing a longitudinal proportion of the member/wire that is disposed within the lumen, or causing the member/wire to enter the lumen, longitudinally contracts the sleeve.
  • the system/apparatus further includes coupling elements coupled to a distal end of the anchor-delivery tool, and the coupling elements are configured to ensnare a proximal end of the sleeve and have a tendency to flex inwardly toward a central longitudinal axis of the anchor-delivery tool in an absence of force applied thereto.
  • the channel is configured to (a) maintain coupling of the coupling elements to the sleeve by pushing against the coupling elements sleeve of the annuloplasty structure, and (b) facilitate decoupling of the anchor-delivery tool from the annuloplasty structure by being removed from the lumen of the sleeve and allowing the coupling elements to flex inwardly and become decoupled from the sleeve.
  • each anchor of the plurality of tissue anchors is a first anchor of the plurality of tissue anchors:
  • an anchor head and a tissue-engaging element being independently advanceable into the lumen of the sleeve by the anchor driver, and being configured to anchor the sleeve to tissue by the tissue -engaging element being driven through the circumferential wall and into the tissue while the anchor head remains in the lumen of the sleeve;
  • the anchor driver is removable from within a lumen of the channel following anchoring of the sleeve using the plurality of tissue anchors.
  • system/apparatus further includes a contraction tool that includes a contraction member-engaging element or wire-engaging element, and the engaging element, subsequently to the anchoring of the sleeve using the plurality of tissue anchors:
  • a snare configured to ensnare the second end of the member or the second wire- end of the wire
  • the snare is configured to ensnare the loop and to pull the loop into the lumen of the channel in order to facilitate application of a contraction force to the contraction member/wire, and the loop is compressible into the lumen of the channel as the snare pulls the loop and a portion of the contraction member/wire through the lumen of the channel.
  • system/apparatus further includes a closure mechanism at the second sleeve -end-portion, the closure mechanism being maintainable in an opened state while the channel passes through the closure mechanism.
  • the channel is slidable with respect to the loop to and to the closure mechanism in order to facilitate implantation of the plurality of tissue anchors.
  • FIGs. 1A-E are schematic illustrations of an example annuloplasty system for treating a native heart valve.
  • FIGs. 2A-F are schematic illustrations of an example annuloplasty system for treating the native heart valve.
  • FIGs. 1A-E are schematic illustrations of an example annuloplasty system 20 that comprises an implant 22.
  • System 20 is for treating a native valve 10 (e.g., an atrioventricular valve, such as the mitral valve or the tricuspid valve) of a heart 4 of a subject.
  • a native valve 10 e.g., an atrioventricular valve, such as the mitral valve or the tricuspid valve
  • Any and all of the methods, techniques, steps, etc. described herein using system 20 can be performed on a living animal or on a non-living cadaver, cadaver heart, simulator, anthropomorphic ghost, etc.
  • Implant 22 comprises an implant body 24, which can be an annuloplasty structure, such as an annuloplasty band or an annuloplasty ring.
  • Implant body 24 comprises a flexible sleeve 25.
  • Sleeve 25 has a first sleeve-end (i.e., a proximal end of sleeve 25), a first sleeve -end-portion 42 (i.e., a proximal end portion of sleeve 25), a second sleeve-end (i.e., a distal end of sleeve 25), a second sleeve -end-portion 44 (i.e., a distal end portion of sleeve 25), and a circumferential wall 46.
  • first sleeve-end i.e., a proximal end of sleeve 25
  • first sleeve -end-portion 42 i.e., a proximal end portion of sleeve 25
  • distal refers to any part of systems described herein that is further from a point of entry into the body of the subject
  • proximal refers to any part of systems described herein that is closer to a point of entry into the body of the subject.
  • Circumferential wall 46 defines a longitudinal lumen 48 between the first and second sleeve -ends.
  • Circumferential wall 46 can be made of a fabric, such as a polyethylene terephthalate fabric, e.g., Dacron (TM).
  • Implant 22 further comprises an elongate contraction member or contraction wire 26.
  • the term“wire” is not intended to limit wire 26 to being metallic, nor to limit the number of strands that it may comprise.
  • the contraction member or contraction wire comprises one or more strands of metal.
  • the contraction member or contraction wire 26 comprises one or more strands of polymer.
  • contraction member or contraction wire 26 is braided or woven.
  • contraction member or contraction wire 26 is coated with a low- friction coating, such as polytetrafluoroethylene (PTFE).
  • PTFE polytetrafluoroethylene
  • Implant body 24 can be configured to be placed partially (e.g., 50%, 60%, 70%, 80%, 90%, 50-99%, etc.) or completely around an annulus of valve 10.
  • Implant body 24 can be attached to tissue (e.g., tissue of a heart valve annulus, etc.) in a variety of ways, such as with anchors, sutures, clips, and/or other attachment means.
  • the implant body 24 is configured to be anchored in place using a plurality of (e.g., 5-20) tissue anchors 32.
  • each tissue anchor comprises a tissue-coupling element 34, and a tool-engaging head 36 fastened to an end of the tissue-coupling element.
  • each anchor 32 is sequentially (and typically independently) intracorporeally delivered into the lumen of the sleeve, and its tissue-coupling element 34 is driven through the circumferential wall and into tissue of the valve annulus, thereby anchoring the sleeve to the valve annulus. Subsequent to attachment to the tissue, longitudinal contraction of implant body 24 circumferentially tightens the valve annulus, thereby improving coaptation of the valve leaflets, and reducing regurgitation.
  • Tissue anchors 32 can also be shaped differently, such as disclosed in PCT application publication WO 2012/176195 to Gross, which is incorporated herein by reference or as otherwise known in the art.
  • flexible sleeve 25 comprises a plurality of radiopaque markers 12, which are positioned along the sleeve at respective longitudinal sites.
  • the markers may provide an indication in a radiographic image (such as a fluoroscopy image) of how much of the sleeve has been deployed at any given point during an implantation procedure, in order to enable setting a desired distance between anchors 32 along the sleeve.
  • the markers comprise a radiopaque ink.
  • annuloplasty structure of implant body 24 is, or shares features with, mutatis mutandis, the annuloplasty structure(s) described in one or more of the following publications, which are incorporated herein by reference.
  • implant 22 is implanted as described in one or more of these publications, mutatis mutandis:
  • Contraction member/wire 26 has a first end or a first wire-end 52 (i.e., a proximal end or a proximal wire -end 52) and a second end or a second wire-end 54 (i.e., a distal end or a distal wire-end 52).
  • first end or first wire-end 52 is attached (e.g., fixedly attached) to sleeve 25 at first sleeve -end-portion 42, and member/wire 26 extends, in association with the circumferential wall of the sleeve, from the first sleeve-end-portion 42 to second sleeve- end-portion 44.
  • the association between member/wire 26 and circumferential wall 46 is provided by the member/wire being woven along or as part of the circumferential wall between first sleeve-end-portion 42 and second sleeve-end-portion 44.
  • first and second sleeve -end-portions 42 and 44 can include more than just the very ends of sleeve 25, i.e. the first and second sleeve -ends.
  • member/wire 26 may not extend all the way to the ends of sleeve 25.
  • at least one anchor 32 can be placed within at least one of first and second sleeve -end-portions 42 and 44, beyond member/wire 26.
  • First end or first wire -end 52 being attached to sleeve 25 at first sleeve-end-portion 42 means that first end or first wire -end 52 is attached to sleeve 25 at an attachment point.
  • First sleeve -end- portion 42 extends between the attachment point and the first sleeve-end.
  • Member/wire 26 extends from the attachment point of first sleeve-end-portion 42 to an entry point of sleeve 25.
  • Second sleeve -end-portion 44 extends between the entry point and the second sleeve-end.
  • member/wire 26 is arranged with respect to sleeve 25 such that pulling (e.g., proximal pulling from a location proximal to implant 22 in a proximal direction) a longitudinal proportion of the member/wire into the lumen (through the entry point at second sleeve-end-portion 44) and/or increasing the amount that is disposed within the lumen longitudinally contracts the sleeve.
  • second end or second wire -end 54 of the member/wire 26 can be positioned inside the lumen.
  • FIG. 1A schematically shows implant 22 following its implantation at valve 10, with the tissue-coupling element 34 of each anchor 32 extending through the circumferential wall of sleeve 25 and into the annulus of the valve.
  • Tool-engaging head 36 is located within lumen 48 of sleeve 25.
  • the tissue into which tissue-coupling elements 34 penetrate is not shown.
  • second end or second wire-end 54 can be disposed within the lumen of sleeve 25 prior to and/or during implantation, or can be disposed outside the lumen but be pullable into the lumen.
  • system 20 further comprises an elongate guide member 28, reversibly coupled to second end or second wire-end 54, and extending proximally though the lumen of sleeve 25, and proximally away from implant 22 (e.g., out of the subject).
  • Contraction tool 60 comprises a contraction member-engaging element or wire-engaging element 62, which is movable longitudinally into lumen 48 (e.g., over guide member 28), and through the lumen to second end or second wire -end 54. Such movement is shown in Fig. IB.
  • tool 60 is dimensioned to be advanceable through lumen 48 past anchor heads 36 already disposed within the lumen.
  • Engaging element 62 is reversibly couplable, e.g., within lumen 48, to second end or second wire-end 54. Such coupling is shown in Fig. 1C.
  • Implant 22 can comprise an appendage 55 coupled to second end or second wire -end 54 of contraction member/wire 26.
  • Engaging element 62 and appendage 55 are mutually configured to facilitate the reversible coupling of the engaging element to the second end or second wire -end of the contraction member/wire.
  • engaging element 62 While coupled to second end or second wire-end 54, engaging element 62 is movable longitudinally toward first sleeve -end-portion 42 (e.g., by being pulled proximally), such that the second end or second wire- end 54 is moved toward the first sleeve-end-portion, thereby drawing contraction member/wire 26 into lumen 48, and longitudinally contracting sleeve 25 (Fig. ID).
  • System 20 further comprises a locking mechanism 70, coupled to contraction tool 60, and advanceable, using the contraction tool, longitudinally through lumen 48 (e.g., over guide member 28) toward second sleeve -end-portion 44 and second end or second wire-end 54 of contraction member/wire 26 (e.g., as shown in Figs. 1B-C).
  • locking mechanism 70 has (i) an unlocked state in which the locking mechanism allows movement of contraction member/wire 26 through the locking mechanism, and increasing of the longitudinal proportion of the member/wire that is disposed within the lumen, and (ii) a locked state in which the locking mechanism inhibits movement of the member/wire through the locking mechanism.
  • locking mechanism 70 is locked, e.g., using tool 60, which thereby also serves as a lock tool 64 that engages locking mechanism 70 within lumen 48.
  • the locking of locking mechanism 70 inhibits the contraction member/wire from moving back out of the lumen, and therefore maintains the desired amount of contraction of the sleeve.
  • locking mechanism 70, locked to contraction member/wire 26 may be too large to exit lumen 48 via the entry point or hole through which member/wire 26 entered the lumen at second sleeve -end-portion 44.
  • locking mechanism 70 can be configured to be attached to an inner wall of sleeve 25.
  • Tool 60 can then be decoupled from member/wire 26 and removed from implant 22 (Fig. IE).
  • the guide member is also decoupled from implant 22, e.g., facilitated by tool 60.
  • the resulting excess 56 of member/wire 26 (i.e., the part of the member/wire that has passed through locking mechanism 70 and does not serve to maintain the contraction of sleeve 25, e.g., the part of the member/wire that is not under tension) is disposed within lumen 48.
  • FIGs. 2A-F are schematic illustrations of an annuloplasty system 120 for treating native valve 10, in accordance with some applications.
  • System 120 comprises an implantable annuloplasty structure 122, which comprises implant body 24 (comprising flexible sleeve 25) and contraction member/wire 26, e.g., as described hereinabove, mutatis mutandis.
  • implant body 24 comprising flexible sleeve 25
  • contraction member/wire 26 e.g., as described hereinabove, mutatis mutandis.
  • structure 122 and the implantation thereof are as described hereinabove for implant 22 and its implantation, mutatis mutandis.
  • member/wire 26 of structure 122 can be arranged with respect to sleeve 25 such that pulling member/wire 26 into the lumen and/or increasing a longitudinal proportion of the member/wire that is disposed within the lumen longitudinally contracts the sleeve.
  • Figs. 2A-F show system 120 not comprising a guide member such as guide member 28, described hereinabove.
  • system 120 may in fact comprise a guide member, and/or system 20 may not comprise a guide member.
  • Contraction member/wire 26 has a first end or first wire-end 52 (i.e., a distal end or distal wire-end of member/wire 26), and a second end or second wire-end 54 (i.e., a proximal end or proximal wire-end of member/wire 26).
  • first end or first wire-end 52 is attached (e.g., fixedly attached) to sleeve 25 at first sleeve-end-portion 42 (i.e., a distal end portion of sleeve 25), and member/wire 26 extends, in association with circumferential wall 46 of the sleeve, from the first sleeve-end-portion 42 toward second sleeve-end-portion 44 (i.e., a proximal end portion of sleeve 25).
  • First end or first wire -end 52 being attached to sleeve 25 at first sleeve- end-portion 42 means that first end or first wire-end 52 is attached to sleeve 25 at an attachment point.
  • First sleeve -end-portion 42 extends between the attachment point and a first sleeve-end (i.e., a distal end of sleeve 25).
  • Member/wire 26 extends from the attachment point at first sleeve- end-portion 42 to an entry point 51 of sleeve 25.
  • Second sleeve-end-portion 44 extends between entry point 51 and a second sleeve -end (i.e., a proximal end of sleeve 25).
  • the association between member/wire 26 and circumferential wall 46 is provided by the member/wire being woven along or as part of the circumferential wall between first sleeve- end-portion 42 and second sleeve-end-portion 44.
  • First end or first wire -end 52 is attached to sleeve 25 at the attachment point generally in a vicinity that is 0-25 mm from the first sleeve-end. That is, one or two anchors 32 are implanted between first end or first wire -end 52 and the first sleeve-end at first sleeve -end- portion 42. In such a manner, the forces applied to contraction member/wire 26 are distributed between the anchors 32 at portion 42.
  • Member/wire 26 extends along body 24 until member/wire 26 enters lumen 48 of sleeve 25 at entry point 51 and a proximal end portion 57 of member/wire 26 is disposed within lumen 48 between entry point 51 and the second sleeve -end at second sleeve- end-portion 44.
  • Second end or second wire-end 54 of the member/wire 26 can be positioned inside the lumen.
  • Second end or second wire -end 54 is provided with a loop 59.
  • proximal end portion 57 of member/wire 26 forms a loop 59 and is secured to itself using a fastener 53.
  • loop 59 is coupled to second end or second wire-end 54.
  • Entry point 51 is generally in a vicinity that is 0-35 mm from the second sleeve -end at second sleeve -end- portion 44.
  • Anchors 32 are used to secure annuloplasty structure 122 to tissue of an annulus of a heart valve of the subject.
  • System 120 is for treating a native valve (e.g., an atrioventricular valve, such as the mitral valve or the tricuspid valve) of the heart of the subject. Any and all of the methods, techniques, steps, etc. described herein using system 120 can be performed on a living animal or on a non-living cadaver, cadaver heart, simulator, anthropomorphic ghost, etc.
  • first and second sleeve -end-portions 42 and 44 can include more than just the very ends of sleeve 25, i.e., the first and second sleeve-ends.
  • member/wire 26 may not extend all the way to the ends of sleeve 25.
  • at least one anchor 32 can be placed within at least one of first and second sleeve -end-portions 42 and 44, beyond member/wire 26.
  • member/wire 26 is arranged with respect to sleeve 25 such that pulling (e.g., proximal pulling from a location proximal to structure 122 in a proximal direction) a longitudinal proportion of the member/wire into the lumen and/or increasing the amount that is disposed within the lumen longitudinally contracts the sleeve.
  • System 120 comprises an implant-structure -delivery tool 110 and an anchor- delivery tool comprising an anchor driver 17 and a channel or tube 18 (e.g., an anchor-delivery channel, anchor-delivery tube, etc.) which houses anchor driver 17 (Fig. 2A).
  • Anchor driver 17 is slidable within tube/channel 18.
  • implant-structure-delivery tool 110 comprises the anchor-delivery tool and a reference-force tube 15.
  • implant- structure-delivery tool 110 and the anchor-delivery tool can be separate devices which can be delivered, introduced and manipulated independently.
  • a distal end 19 of anchor-delivery tube/channel 18 can be introduced into and disposed within lumen 48 of sleeve 25 of structure 122.
  • Tube/channel 18 can slide through and with respect to loop 59 in order to facilitate delivery of anchors 32.
  • the distal end 19 of anchor-delivery tube/channel 18 begins closest to first sleeve -end-portion 42 and deploys a first anchor 32 through wall 46 of sleeve 25.
  • anchor-delivery tube 18 is retracted proximally toward second sleeve -end-portion 44 by sliding with respect to loop 59 while loop 59 remains in place and generally stationary.
  • Techniques for implanting structure 122 and anchoring structure 122 to tissue using anchors 32 may be practiced in combinations with techniques as described in PCT Publication WO 14/064694 to Sheps, which is incorporated herein by reference.
  • a force is applied to the second sleeve -end-portion 44 by a distal end of reference- force tube 15 of implant-delivery tool 110 used to deliver structure 122.
  • anchor- delivery tube 18 is advanceable within a lumen of reference -force tube 15 and through lumen 48 of sleeve 25 such that a portion of anchor-delivery tube 18 that is disposed within the sleeve is coaxial with the sleeve.
  • Distal end 19 of anchor-delivery tube 18 is disposed in contact with an inner wall of sleeve 25 at a distal end thereof. Additionally, a distal end portion of anchor-delivery tube 18 may comprise one or more radiopaque markers.
  • structure 122 comprises a closure mechanism 220 at second sleeve -end-portion 44 for closing an opening at second sleeve-end-portion portion 44 of sleeve 25.
  • second sleeve-end -portion 44 may be left open when structure 122 is implanted, or may be closed as described in PCT application publication WO 2012/176195 to Gross, which is incorporated herein by reference.
  • Closure mechanism 220 is coupled to sleeve 25 such as by being sutured to sleeve 25 using one or more sutures.
  • Closure mechanism 220 comprises a flap 230 (e.g., a door) that has an open state and a closed state (e.g., as shown in Fig. 2F), and is configured to be biased toward assuming the closed state, such as described in PCT application publication WO 2014/064694 to Sheps, which is incorporated herein by reference.
  • flap 230 When flap 230 is in the closed state, the lumen of sleeve 25 is in reduced communication with outside of the sleeve compared to when the flap is in the open state.
  • closure mechanism comprises a frame 222 to which flap 230 is articulatably coupled at an articulation point, and flap 230 is elastically biased toward assuming the closed state, e.g., by the frame, the articulation point, and the flap comprising a continuous piece of shape -memory material such as nitinol.
  • frame 222 is generally cylindrical, which reinforces the proximal end of sleeve 25.
  • closure mechanism 220 comprises (e.g., is coated with) an anti-thrombotic agent.
  • anchor-delivery tube 18 When a portion of anchor-delivery tube 18 is disposed within lumen 48 of sleeve 25, flap 230 is held in the open state. Anchor-delivery tube 18 thereby provides a working channel between outside the body of the subject, and lumen 48 of sleeve 25, such as for delivery of anchors 32, as described hereinabove. When anchor-delivery tube 18 is removed from lumen 48 (e.g., slid out of a proximal opening of the sleeve), flap 230 automatically moves toward the closed state.
  • Sleeve 25 can be reversibly couplable to reference -force tube 15 via one or more coupling elements 224 (e.g., sleeve -coupling elements) which are coupled to a distal end of the reference-force tube, such as described in PCT application publication WO 2014/064694 to Sheps, which is incorporated herein by reference.
  • Each coupling element 224 is shaped to define a distal projection, which is configured to be disposed within a respective negative space, such as a recess or a hole (not shown) in frame 222, thereby coupling the coupling element to closure mechanism 220, and thereby to sleeve 25.
  • Frame 222 can be generally cylindrical, and the hole can be defined in a lateral portion of the cylindrical shape.
  • Coupling elements 224 can be configured to have a natural tendency (e.g., to be biased) to flex inwardly toward a central longitudinal axis of tube 15.
  • anchor-delivery tube 18 inhibits the coupling elements from decoupling from frame 222 of closure mechanism 220.
  • distal end 19 of anchor-delivery tube 18 is slid proximally past closure mechanism 220 (and proximally past coupling elements 224)
  • the coupling elements automatically decouple from frame 222 of closure mechanism 220 by flexing inwardly toward the central longitudinal axis of tube 15, thereby allowing tube 15 to become decoupled from sleeve 25.
  • Reference -force tube 15 may then be withdrawn proximally from sleeve 25.
  • system 120 facilitates:
  • anchor-delivery tube 18 when distal end 19 of anchor-delivery tube 18 is disposed within the lumen of sleeve 25 of implant structure 122 (a) coupling of reference-force tube 15 to sleeve 25, and (b) fluid communication between a proximal end of anchor-delivery tube 18 (e.g., a proximal end of the lumen thereof) and the lumen of the sleeve, and
  • closure mechanism 220 e.g., withdrawn from the lumen of the sleeve
  • closure mechanism 220 e.g., withdrawn from the lumen of the sleeve
  • second sleeve -end- portion 44 of sleeve 25 of implant structure 122 e.g., withdrawn from the lumen of the sleeve
  • automatic decoupling of reference-force tube 15 from the sleeve of the implant structure
  • FIG. 2A schematically shows structure 122 following its initial implantation at the mitral valve, in which the first three tissue anchors 32 are used to anchor structure 122 to the tissue of the annulus.
  • Tissue -coupling element 34 of each anchor 32 extends through circumferential wall 46 of sleeve 25 and into the annulus of the valve while tool-engaging head 36 of each anchor 32 is located (remains) within the lumen 48 of structure 122.
  • the tissue into which tissue-coupling elements 34 penetrate is not shown.
  • second end or second wire -end 54 is disposed within the lumen of sleeve 25 prior to and/or during implantation.
  • Anchor-delivery tube 18 is used to facilitate delivery of anchor 32. After each anchor 32 is delivered, anchor-delivery tube 18 is retracted proximally, i.e., toward second sleeve- end-portion 44 of sleeve 25. During implantation of anchors 32, loop 59 surrounds a portion of anchor-delivery tube 18. As each subsequent anchor 32 is delivered, anchor-delivery tube 18 is retracted toward second sleeve-end-portion 44 by sliding with respect to loop 59 while loop 59 remains in place and generally stationary. Anchors 32 are implanted using techniques described, for example, with reference to Figs. 10A-I of PCT Publication WO 14/064694 to Sheps, which is incorporated herein by reference.
  • Fig. 2B shows structure 122 following implantation thereof.
  • a plurality of anchors 32 is used to anchor structure 122 to the tissue.
  • the plurality of tissue anchors 32 comprises at least one second sleeve-end-portion tissue anchor 132, e.g., two anchors 132 as shown.
  • any suitable number of second sleeve -end-portion tissue anchors 132 can be implanted, e.g., between 1 and 4 by way of illustration and not limitation.
  • second sleeve-end-portion tissue anchors 132 are implanted between entry point 51 of contraction member/wire 26 and the second sleeve -end at second sleeve -end-portion 44.
  • anchors 132 are implanted in a vicinity of proximal end portion 57 of member/wire 26.
  • second sleeve -end-portion tissue anchors 132 help distribute forces between anchors 132 from entry point 51 toward the second sleeve-end at second sleeve -end- portion 44.
  • a contraction tool is used to facilitate contraction of the implant.
  • the contraction tool passes through anchor-delivery tube 18 and comprises an outer tube 160, an inner tube 162 slidably disposed within outer tube 160, and an engaging element or wire-engaging element 163 slidably disposed within inner tube 162.
  • the contraction tool is movable longitudinally into lumen 48, and through lumen 48 of sleeve 25 toward second end or second wire-end 54 provided with loop 59.
  • loop 59 no longer surrounds anchor-delivery tube 18 because anchor-delivery tube 18 has been retracted toward reference-force tube 15 in order to free loop 59 from around anchor-delivery tube 18.
  • distal end 19 of anchor-delivery tube 18 is disposed proximally to loop 59.
  • Distal end 19 of anchor-delivery tube 18 is still within lumen 48 of sleeve 25 and anchor-delivery tube 18 at this stage still remains within the opening at second sleeve-end-portion 44 such that an external wall of anchor-delivery tube 18 retains closure mechanism 220 in an opened state.
  • Engaging element 163 comprises an elongate member, such as a wire, rod, line, suture, tube, a flat Nitinol wire, etc., and, in some implementations, has a distal end portion folded proximally so as to form a curved portion. Worded differently, engaging element 163 can be folded onto itself to define a hairpin-shaped segment defining a U-shaped bend. In some implementations, the pre-shaped distal end portion of engaging element 163 is biased to assume a closed configuration. The curved portion can be shaped so that the distal end of engaging element 163 flexes inwardly toward a longitudinal axis of inner tube 162.
  • the curved portion is contiguous with a distal portion of engagement element 163 located proximal (in the direction of extension of engaging element 163) the distal end of engaging element 163.
  • the distal end of engaging element 163 can be biased toward the distal portion of engaging element 163.
  • the distal end of engaging element 163 in the closed configuration, is radially closer to the distal portion of engaging element 163 (or to inner tube 162) than in the open configuration.
  • FIG. 2B shows the contraction tool transitioning from a delivery configuration, in which the distal end portion of engaging element 163 is in its closed configuration, to a gripping configuration shown in Fig. 2C.
  • the distal end of engaging element 163 is disposed within a lumen of outer tube 160.
  • a distal end of inner tube 162 is positioned proximal the curved portion and the distal end of engaging element 163 is positioned radially between outer tube 160 and inner tube 162.
  • Fig. 2C shows the pre-shaped distal end portion of engaging element 163 fully exposed from within a lumen of outer tube 160.
  • outer tube 160 is positioned proximal the distal end of engaging element 163 and inner tube 162 extends into the curved portion (i.e., the U- shaped bend) of the distal end portion of engaging element 163 so as to force the distal end of engaging element 163 to flex outwardly and thereby move the distal end portion of engaging element 163 into the open configuration.
  • a distance between the distal end of engaging element 163 and an outer surface of inner tube 162 is enough to grip loop 59 so as to facilitate coupling between contraction tool 160 and loop 59.
  • inner tube 162 is retracted proximally so as to no longer engage the curved portion, the distal end portion of engaging element 163 moves back into the closed configuration.
  • Outer tube 160 can then be advanced distally to cover at least the distal end of engaging element 163, as shown in Fig. 2B.
  • the contraction tool While coupled to second end or second wire -end 54, i.e., by ensnaring loop 59 when the distal end portion of engaging element 163 assumes its closed configuration, the contraction tool is movable longitudinally toward the opening at the second sleeve-end 44 (i.e., by being pulled proximally), such that the second end or second wire -end 54 is moved toward the second sleeve- end, thereby drawing additional portions of contraction member/wire 26 into lumen 48 through entry point 51 , and longitudinally contracting sleeve 25 initially (Fig. 2D).
  • Distal end 19 of anchor- delivery tube 18 is still within lumen 48 of sleeve 25 and anchor-delivery tube 18 at this stage still remains within the opening at second sleeve-end-portion 44 such that an external wall of anchor- delivery tube 18 retains closure mechanism 220 in an opened state. It is to be noted that the majority of contraction occurs subsequently to this initial step shown in Fig. 2D, as is described hereinbelow with reference to Figs. 2E-F.
  • Loop 59 comprises a super-elastic and flexible material, e.g., nitinol. Pulling on loop 59 when the distal end portion of engagement element 163 is in the closed configuration pulls loop 59 toward distal end 19 of anchor-delivery tube 18. Loop 59 is compressed and constrained by the wall of anchor-delivery tube 18 as it is pulled within the lumen of anchor-delivery tube 18 so as to draw a portion of contraction member/wire 26 within the lumen of anchor-delivery tube 18.
  • System 120 comprises a force-distributing- element- and lock-delivering -tool 164 which is advanceable within the lumen of anchor-delivery tube 18 and over the contraction tool.
  • Tool 164 is configured to deliver a force -distributing element 300.
  • Lorce-distributing element 300 can be coupled to a distal end of tool 164. Though in some implementations, force-distributing element 300 can be positioned distal to tool 164 and pushed through anchor-delivery tube 18 by tool 164.
  • force -distributing element 300 can be slidable with respect to and out of a lumen of a distal end of tool 164, such as by means of a pusher tube (not shown) slidably disposed within tool 164.
  • Lorce-distributing element 300 is configured to surround proximal end portion 57 of contraction member/wire 26.
  • Tool 164 and force -distributing element 300 slide around the contraction tool. Once tool 164 and force-distributing element 300 slide beyond the distal end of the contraction tool, tool 164 and force-distributing element 300 slide directly along a portion of contraction member/wire 26, including portion 57, that is now disposed within a lumen of anchor-delivery tube 18.
  • Force-distributing element 300 comprises a flexible structure having a lumen which surrounds contraction member/wire 26 at proximal end portion 57.
  • force- distributing element 300 comprises a tubular element having a plurality of slits to increase flexibility of element 300.
  • force -distributing element 300 comprises a coiled element.
  • 2F shows contraction of sleeve 25. Contraction of structure 122 occurs from within lumen 48 as member/wire is being pulled, and also from within delivery tool 110 that houses anchor-delivery tube 18, since contracting member/wire 26 is pulled within a lumen of anchor-delivery tube 18.
  • force-distributing element 300 distributes contraction forces between second sleeve -end-portion tissue anchors 132 from entry point 51 toward the second sleeve -end. That is, contraction is restricted to the portion of implant body 24 that is between entry point 51 of contraction member/wire and first end or first wire-end 52.
  • distal end 19 of anchor-delivery tube 18 is still within lumen 48 of sleeve 25 and anchor- delivery tube 18 at this stage still remains within the opening at second sleeve-end-portion 44 such that an external wall of anchor-delivery tube 18 retains closure mechanism 220 in an opened state.
  • tool 164 delivers toward a proximal end of element 300 a locking mechanism 170, e.g., a lock, in an unlocked state, e.g., maintained in the unlocked state by lock tool 164.
  • Locking mechanism 170 is delivered around member/wire 26.
  • force-distributing element 300 is delivered together with locking mechanism 170 in its unlocked state. Only once contraction of member/wire 26 has been achieved, locking mechanism 170 is transitioned to the locked state to lock member/wire 26 in place with respect to force-distributing element 300, in order to maintain a contraction state of sleeve 25.
  • Locking mechanism 170 has an unlocked state in which locking mechanism 170 allows movement of member/wire 26 through locking mechanism 170 and allows increasing of the longitudinal proportion of member/wire 26 that is disposed within lumen 48 of sleeve 25. Locking mechanism 170 has a locked state in which locking mechanism 170 inhibits movement of member/wire 26 through locking mechanism 170.
  • Locking mechanism 170 is locked, e.g., using lock tool 164, such as by disengaging the lock tool from the locking mechanism.
  • lock tool 164 is biased to assume its locked state, and lock tool 164 is configured to retain the locking mechanism in its unlocked state while the lock tool is engaged with the locking mechanism.
  • disengagement of lock tool 164 from locking mechanism 170 allows the locking mechanism to transition into its locked state.
  • Other locking mechanisms and lock tools described herein may also operate in this manner, mutatis mutandis.
  • Tool 164 can comprise a cutting element which can sever member/wire 26 once locking mechanism 170 is locked in place.
  • Locking mechanism or lock 170 locks in place contraction member/wire 26.
  • the contraction tool e.g., engaging element 163 thereof
  • the contraction tool can then be decoupled from member/wire 26 and removed from structure 122 (Fig. 2F).
  • the resulting excess of member/wire 26 is cut in order to avoid this loose portion of the member/wire from moving freely within the heart.
  • excess member/wire 26 is removed.
  • the delivery tool 110 can comprise a cutter, or a dedicated cutter can be used - e.g., advanced over and along member/wire 26.
  • excess member/wire 26 can be pushed back into lumen 48 of sleeve 25, e.g. by means of the contraction tool or tool 164, and can be enclosed within sleeve 25 in order to avoid this loose portion of member/wire 26 from moving freely within the heart.
  • Implant-delivery tool 110 (comprising reference -force tube 15 and channel/tube 18, inter alia) is then decoupled from structure 122 by removing anchor-delivery tube 18 from within lumen 48 of sleeve 25 of structure 122. Removing of anchor-delivery tube 18 from within lumen 48 enables closure mechanism 220 to assume its closed state. In the absence of anchor-delivery tube 18 within frame 222, anchor-delivery tube 18 no longer pushes against coupling elements 224 and coupling elements 224 assume their natural tendency to flex inwardly toward the central longitudinal axis of tube 15. As elements 224 flex inwardly, elements 224 are decoupled from frame 222 of structure 122 and tube 15 is disengaged from structure 122.
  • anchor- delivery tube 18 no longer holds open flap 230, if present, and flap 230 assumes the natural tendency toward the closed state.
  • flap 230 also prevents migration of locking mechanism 170 in an event in which locking mechanism 170 were to be decoupled from member/wire 26.
  • closure mechanism 220 retains locking mechanism 170 within lumen 48 of structure 122.
  • Implant-delivery tool 110 (comprising reference-force tube 15, anchor-delivery tube 18, contraction tool 160, force-distributing-element and lock-delivering tool 164, inter alia) used to deliver structure 122, and excess portions of member/wire 26 extending from loop 59 are extracted from the body of the subject. That is, system 120 advantageously provides a system in which implant-delivery tool 110, remains coupled to structure 122 during contraction of structure 122 and during performing of the annuloplasty on the heart valve of the subject.
  • contraction member/wire 26 occurs from second sleeve -end-portion 44, i.e., from a proximal portion of structure 122 and the direction of the pulling and contraction is proximal. That is, contraction of structure 122 occurs at the proximal end of structure 122 and from within lumen 48 of structure 122 while implant-delivery tool 110 is coupled to structure 122. Contraction is performed under the guidance of imaging and multiple contractions of member/wire 26 can be performed responsively to feedback, e.g., tactile, pressure gauge, and imaging.
  • feedback e.g., tactile, pressure gauge, and imaging.
  • the locking mechanism of a given system can be replaced with a one-way mechanism such as a ratchet, mutatis mutandis.
  • the one-way mechanism can be coupled to the contraction member/wire, and to the sleeve at the second sleeve -end-portion, and can be configured to allow one-way movement of the member/wire through the one-way mechanism.
  • the system would be arranged such that the one way mechanism (i) allows increasing the longitudinal proportion of the member/wire that is disposed within the lumen, and (ii) inhibits reducing the longitudinal proportion of the member/wire that is disposed within the lumen.
  • Methods involving the systems and devices herein can include any of the steps described above, e.g., to implant, attach, contract, lock, etc. the systems, devices, components, etc.
  • methods involve transvascularly (e.g., transfemorally, etc.) advancing the system, device, implant, etc. to a target location, such as a heart valve annulus or simulation of a heart valve annulus.
  • the methods involve attaching the system, device, implant, etc. to the target location (e.g., after advancement as described previously). Attaching can involve anchoring, suturing, clipping, and/or using other attachment means to attach the system, device, implant, etc. to the target location.
  • the methods also involve contracting the system, device, implant, etc., which can be done by pulling or otherwise exerting force on a contraction member/wire (which can be attached, configured, and/or arranged as described in any of the embodiments above) to cause the system, device, implant, etc. to contract (e.g., to a contracted configuration with a smaller length, diameter, and/or radius of curvature).
  • the contracting can be done as described with respect to any of the embodiments above.
  • the methods can also include locking a locking mechanism, lock, locking device, etc. to hold the system, device, implant, etc. in the contracted configuration.
  • the locking mechanism, lock, locking device, etc. can be the same and function and/or be operated in the same way as any of those described above.

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PCT/IL2020/050808 2019-07-23 2020-07-22 Contraction of an annuloplasty structure Ceased WO2021014440A2 (en)

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JP2021575007A JP7592647B2 (ja) 2019-07-23 2020-07-22 弁形成構造の収縮
EP20754396.8A EP4003231B1 (en) 2019-07-23 2020-07-22 Contraction of an annuloplasty structure
CN202080046078.0A CN114072101A (zh) 2019-07-23 2020-07-22 瓣环成形术结构的收缩
CA3141295A CA3141295A1 (en) 2019-07-23 2020-07-22 Contraction of an annuloplasty structure
US17/581,821 US12502277B2 (en) 2019-07-23 2022-01-21 Contraction of an annuloplasty structure

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Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11116634B2 (en) 2008-12-22 2021-09-14 Valtech Cardio Ltd. Annuloplasty implants
US11123191B2 (en) 2018-07-12 2021-09-21 Valtech Cardio Ltd. Annuloplasty systems and locking tools therefor
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US11185412B2 (en) 2009-05-04 2021-11-30 Valtech Cardio Ltd. Deployment techniques for annuloplasty implants
US11197759B2 (en) 2011-11-04 2021-12-14 Valtech Cardio Ltd. Implant having multiple adjusting mechanisms
US11202709B2 (en) 2009-02-17 2021-12-21 Valtech Cardio Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11344310B2 (en) 2012-10-23 2022-05-31 Valtech Cardio Ltd. Percutaneous tissue anchor techniques
US11344414B2 (en) 2006-12-05 2022-05-31 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11395648B2 (en) 2012-09-29 2022-07-26 Edwards Lifesciences Corporation Plication lock delivery system and method of use thereof
US11497605B2 (en) 2005-03-17 2022-11-15 Valtech Cardio Ltd. Mitral valve treatment techniques
US11534583B2 (en) 2013-03-14 2022-12-27 Valtech Cardio Ltd. Guidewire feeder
US11540835B2 (en) 2016-05-26 2023-01-03 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US11583400B2 (en) 2012-12-06 2023-02-21 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for guided advancement of a tool
US11602434B2 (en) 2009-12-02 2023-03-14 Edwards Lifesciences Innovation (Israel) Ltd. Systems and methods for tissue adjustment
US11617652B2 (en) 2009-10-29 2023-04-04 Edwards Lifesciences Innovation (Israel) Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US11660192B2 (en) 2015-12-30 2023-05-30 Edwards Lifesciences Corporation System and method for reshaping heart
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US11660191B2 (en) 2008-03-10 2023-05-30 Edwards Lifesciences Corporation Method to reduce mitral regurgitation
US11666442B2 (en) 2018-01-26 2023-06-06 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11723774B2 (en) 2009-05-07 2023-08-15 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
US11744573B2 (en) 2013-08-31 2023-09-05 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US11766263B2 (en) 2013-10-23 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Anchor magazine
US11766327B2 (en) 2009-05-04 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Implantation of repair chords in the heart
US11779463B2 (en) 2018-01-24 2023-10-10 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US11793505B2 (en) 2013-02-26 2023-10-24 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US11819411B2 (en) 2019-10-29 2023-11-21 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
US11832784B2 (en) 2017-11-02 2023-12-05 Edwards Lifesciences Innovation (Israel) Ltd. Implant-cinching devices and systems
US11857415B2 (en) 2011-11-08 2024-01-02 Edwards Lifesciences Innovation (Israel) Ltd. Controlled steering functionality for implant-delivery tool
US11883611B2 (en) 2017-04-18 2024-01-30 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US11890194B2 (en) 2013-03-15 2024-02-06 Edwards Lifesciences Corporation Translation catheters, systems, and methods of use thereof
US11890193B2 (en) 2015-12-30 2024-02-06 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US11890190B2 (en) 2012-10-23 2024-02-06 Edwards Lifesciences Innovation (Israel) Ltd. Location indication system for implant-delivery tool
US11969348B2 (en) 2011-12-12 2024-04-30 Edwards Lifesciences Corporation Cardiac valve replacement
US12023247B2 (en) 2020-05-20 2024-07-02 Edwards Lifesciences Corporation Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus
US12035898B2 (en) 2005-04-22 2024-07-16 Edwards Lifesciences Corporation Catheter-based tissue remodeling devices and methods
US12097118B2 (en) 2009-10-29 2024-09-24 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchor for heart implant
US12102533B2 (en) 2016-07-08 2024-10-01 Edwards Lifesciences Innovation (Israel) Ltd. Adjustable annuloplasty device with alternating peaks and troughs
US12138168B2 (en) 2008-12-22 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US12138164B2 (en) 2015-04-30 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty technologies
US12138165B2 (en) 2011-06-23 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty implants
US12208006B2 (en) 2019-09-25 2025-01-28 Edwards Lifesciences Corporation Constricting a cardiac valve annulus using a cord that has a loop portion and a single second portion
US12226096B2 (en) 2019-05-29 2025-02-18 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchor handling systems and methods
US12350158B2 (en) 2009-05-04 2025-07-08 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty ring delivery catheters
US12364606B2 (en) 2019-07-23 2025-07-22 Edwards Lifesciences Innovation (Israel) Ltd. Fluoroscopic visualization of heart valve anatomy
US12396718B2 (en) 2020-06-19 2025-08-26 Edwards Lifesciences Corporation Self-stopping tissue anchors
US12409032B2 (en) 2011-06-23 2025-09-09 Edwards Lifesciences Innovation (Israel) Ltd. Percutaneous implantation of an annuloplasty structure
US12419749B2 (en) 2019-08-30 2025-09-23 Edwards Lifesciences Innovation (Israel) Ltd. Anchor channel tip
US12440648B2 (en) 2019-08-28 2025-10-14 Edwards Lifesciences Innovation (Israel) Ltd. Low-profile steerable catheter
US12485010B2 (en) 2009-05-07 2025-12-02 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
US12502277B2 (en) 2019-07-23 2025-12-23 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US12588907B2 (en) 2020-03-23 2026-03-31 Edwards Lifesciences Innovation (Israel) Ltd. Self-locking winch

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8475525B2 (en) * 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US12502167B2 (en) 2019-07-16 2025-12-23 Edwards Lifesciences Corporation Tissue remodeling systems and methods
CN116327445B (zh) * 2023-03-28 2024-06-25 晨兴(南通)医疗器械有限公司 瓣环修复器械及修复方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010128503A2 (en) 2009-05-04 2010-11-11 Valtech Cardio, Ltd. Deployment techniques for annuloplasty ring and over-wire rotation tool
WO2012176195A2 (en) 2011-06-23 2012-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
WO2013069019A2 (en) 2011-11-08 2013-05-16 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
WO2014064694A2 (en) 2012-10-23 2014-05-01 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool

Family Cites Families (786)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL143127B (nl) 1969-02-04 1974-09-16 Rhone Poulenc Sa Versterkingsorgaan voor een defecte hartklep.
US3604488A (en) 1969-11-19 1971-09-14 Vermont American Corp Screwdriver attachment
US3840018A (en) 1973-01-31 1974-10-08 M Heifetz Clamp for occluding tubular conduits in the human body
US3881366A (en) 1973-11-19 1975-05-06 Gen Motors Corp Adjustable steering column
US3898701A (en) 1974-01-17 1975-08-12 Russa Joseph Implantable heart valve
US4042979A (en) 1976-07-12 1977-08-23 Angell William W Valvuloplasty ring and prosthetic method
US4118805A (en) 1977-02-28 1978-10-10 Codman & Shurtleff, Inc. Artificial sphincter
ES474582A1 (es) 1978-10-26 1979-11-01 Aranguren Duo Iker Procedimiento para la instalacion de valvulas mitrales en sulugar anatomico, mediante anclaje de cordajes en pilar arti-ficial
US4214349A (en) 1978-11-30 1980-07-29 Midland-Ross Corporation Tie wrap
ES244903Y (es) 1979-07-31 1980-12-01 Protesis anular regulable para cirugia cardiaca
GB2084468B (en) 1980-09-25 1984-06-06 South African Inventions Surgical implant
US4473928A (en) 1980-11-20 1984-10-02 Tridon Limited Hose clamps
DE3230858C2 (de) 1982-08-19 1985-01-24 Ahmadi, Ali, Dr. med., 7809 Denzlingen Ringprothese
US4434828A (en) 1982-12-20 1984-03-06 Richard Trincia Screwdriver with handle for storing bits
US4625727A (en) 1985-01-24 1986-12-02 Leiboff Arnold R Anastomosis device with excisable frame
US4712549A (en) 1985-07-01 1987-12-15 Edward Weck & Co. Automatic hemostatic clip applier
CA1303298C (en) 1986-08-06 1992-06-16 Alain Carpentier Flexible cardiac valvular support prosthesis
US4961738A (en) 1987-01-28 1990-10-09 Mackin Robert A Angioplasty catheter with illumination and visualization within angioplasty balloon
US4917698A (en) 1988-12-22 1990-04-17 Baxter International Inc. Multi-segmented annuloplasty ring prosthesis
CA2049971C (en) 1989-02-13 2001-08-21 Hung L. Lam Selectively flexible annuloplasty ring
US5290300A (en) 1989-07-31 1994-03-01 Baxter International Inc. Flexible suture guide and holder
US5632746A (en) 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
US4935027A (en) 1989-08-21 1990-06-19 Inbae Yoon Surgical suture instrument with remotely controllable suture material advancement
SE467459B (sv) 1990-09-25 1992-07-20 Allset Marine Lashing Ab Vridlaas foer hoernlaadorna till containrar
US5626609A (en) 1990-10-05 1997-05-06 United States Surgical Corporation Endoscopic surgical instrument
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
US5064431A (en) 1991-01-16 1991-11-12 St. Jude Medical Incorporated Annuloplasty ring
US5108420A (en) 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
US5346498A (en) 1991-11-06 1994-09-13 Imagyn Medical, Inc. Controller for manipulation of instruments within a catheter
DE69229604T2 (de) 1991-11-29 2000-03-02 William Cook Europe A/S, Bjaeverskov Verschlussprothese für die katheterplazierung
US5201880A (en) 1992-01-27 1993-04-13 Pioneering Technologies, Inc. Mitral and tricuspid annuloplasty rings
US5325845A (en) 1992-06-08 1994-07-05 Adair Edwin Lloyd Steerable sheath for use with selected removable optical catheter
US5300034A (en) 1992-07-29 1994-04-05 Minnesota Mining And Manufacturing Company Iv injection site for the reception of a blunt cannula
US5258008A (en) 1992-07-29 1993-11-02 Wilk Peter J Surgical stapling device and associated method
ES2049653B1 (es) 1992-10-05 1994-12-16 Velazquez Francisco Farrer Dispositivo corrector de la incontinencia urinaria femenina.
US6074417A (en) 1992-11-16 2000-06-13 St. Jude Medical, Inc. Total mitral heterologous bioprosthesis to be used in mitral or tricuspid heart replacement
US5643317A (en) 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5383852A (en) 1992-12-04 1995-01-24 C. R. Bard, Inc. Catheter with independent proximal and distal control
DE69322370C5 (de) 1993-02-18 2009-01-08 Ethicon Endo-Surgery, Inc., Cincinnati Laparoskopisches einstellbares Magenband
US5449368A (en) 1993-02-18 1995-09-12 Kuzmak; Lubomyr I. Laparoscopic adjustable gastric banding device and method for implantation and removal thereof
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5972030A (en) 1993-02-22 1999-10-26 Heartport, Inc. Less-invasive devices and methods for treatment of cardiac valves
US6010531A (en) 1993-02-22 2000-01-04 Heartport, Inc. Less-invasive devices and methods for cardiac valve surgery
US6125852A (en) 1993-02-22 2000-10-03 Heartport, Inc. Minimally-invasive devices and methods for treatment of congestive heart failure
US5715817A (en) 1993-06-29 1998-02-10 C.R. Bard, Inc. Bidirectional steering catheter
US5450860A (en) 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
US5651785A (en) 1993-09-20 1997-07-29 Abela Laser Systems, Inc. Optical fiber catheter and method
US5464404A (en) 1993-09-20 1995-11-07 Abela Laser Systems, Inc. Cardiac ablation catheters and method
AU1011595A (en) 1994-01-13 1995-07-20 Ethicon Inc. Spiral surgical tack
US5843120A (en) 1994-03-17 1998-12-01 Medinol Ltd. Flexible-expandable stent
US6217610B1 (en) 1994-07-29 2001-04-17 Edwards Lifesciences Corporation Expandable annuloplasty ring
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5593424A (en) 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US20020198586A1 (en) 1995-04-12 2002-12-26 Kanji Inoue Appliance collapsible for insertion into a human organ and capable of resilient restoration
WO1996040006A1 (en) 1995-06-07 1996-12-19 St. Jude Medical, Inc. Adjustable sizing apparatus for heart annulus
US5676653A (en) 1995-06-27 1997-10-14 Arrow International Investment Corp. Kink-resistant steerable catheter assembly
US5662683A (en) 1995-08-22 1997-09-02 Ortho Helix Limited Open helical organic tissue anchor and method of facilitating healing
US5749371A (en) 1995-10-06 1998-05-12 Zadini; Filiberto P. Automatic guidewire placement device for medical catheters
DE69630235T2 (de) 1995-12-01 2004-08-05 Medtronic, Inc., Minneapolis Anuloplastik-Prothese
US5730150A (en) 1996-01-16 1998-03-24 B. Braun Medical Inc. Guidewire dispenser
US5957953A (en) 1996-02-16 1999-09-28 Smith & Nephew, Inc. Expandable suture anchor
US5702397A (en) 1996-02-20 1997-12-30 Medicinelodge, Inc. Ligament bone anchor and method for its use
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US5716370A (en) 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US6132390A (en) 1996-02-28 2000-10-17 Eupalamus Llc Handle for manipulation of a stylet used for deflecting a tip of a lead or catheter
US5782844A (en) 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US6702846B2 (en) 1996-04-09 2004-03-09 Endocare, Inc. Urological stent therapy system and method
US5885228A (en) 1996-05-08 1999-03-23 Heartport, Inc. Valve sizer and method of use
US6569188B2 (en) 1996-08-05 2003-05-27 Arthrex, Inc. Hex drive bioabsorbable tissue anchor
US5669919A (en) 1996-08-16 1997-09-23 Medtronic, Inc. Annuloplasty system
US5752963A (en) 1996-08-19 1998-05-19 Bristol-Myers Squibb Company Suture anchor driver
US5830221A (en) 1996-09-20 1998-11-03 United States Surgical Corporation Coil fastener applier
CA2217406C (en) 1996-10-04 2006-05-30 United States Surgical Corporation Suture anchor installation system with disposable loading unit
US5716397A (en) 1996-12-06 1998-02-10 Medtronic, Inc. Annuloplasty device with removable stiffening element
US5935098A (en) 1996-12-23 1999-08-10 Conceptus, Inc. Apparatus and method for accessing and manipulating the uterus
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US6050936A (en) 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
US6406420B1 (en) 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US5961440A (en) 1997-01-02 1999-10-05 Myocor, Inc. Heart wall tension reduction apparatus and method
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6074401A (en) 1997-01-09 2000-06-13 Coalescent Surgical, Inc. Pinned retainer surgical fasteners, instruments and methods for minimally invasive vascular and endoscopic surgery
US5961539A (en) 1997-01-17 1999-10-05 Segmed, Inc. Method and apparatus for sizing, stabilizing and/or reducing the circumference of an anatomical structure
US5938616A (en) 1997-01-31 1999-08-17 Acuson Corporation Steering mechanism and steering line for a catheter-mounted ultrasonic transducer
US5702398A (en) 1997-02-21 1997-12-30 Tarabishy; Sam Tension screw
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US5876373A (en) 1997-04-04 1999-03-02 Eclipse Surgical Technologies, Inc. Steerable catheter
WO1998046149A1 (en) 1997-04-11 1998-10-22 Taccor, Inc. Steerable catheter with rotatable tip electrode and method of use
AU9225598A (en) 1997-09-04 1999-03-22 Endocore, Inc. Artificial chordae replacement
FR2768324B1 (fr) 1997-09-12 1999-12-10 Jacques Seguin Instrument chirurgical permettant, par voie percutanee, de fixer l'une a l'autre deux zones de tissu mou, normalement mutuellement distantes
US5984959A (en) 1997-09-19 1999-11-16 United States Surgical Heart valve replacement tools and procedures
US6206888B1 (en) 1997-10-01 2001-03-27 Scimed Life Systems, Inc. Stent delivery system using shape memory retraction
US6174332B1 (en) 1997-12-05 2001-01-16 St. Jude Medical, Inc. Annuloplasty ring with cut zone
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
AU2011699A (en) 1997-12-29 1999-07-19 Ivan Vesely System for minimally invasive insertion of a bioprosthetic heart valve
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US6251092B1 (en) 1997-12-30 2001-06-26 Medtronic, Inc. Deflectable guiding catheter
US6533807B2 (en) 1998-02-05 2003-03-18 Medtronic, Inc. Radially-expandable stent and delivery system
US20020087048A1 (en) 1998-02-24 2002-07-04 Brock David L. Flexible instrument
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6143024A (en) 1998-06-04 2000-11-07 Sulzer Carbomedics Inc. Annuloplasty ring having flexible anterior portion
US6074341A (en) 1998-06-09 2000-06-13 Timm Medical Technologies, Inc. Vessel occlusive apparatus and method
AU761192B2 (en) 1998-06-10 2003-05-29 Converge Medical, Inc. Sutureless anastomosis systems
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
US6106550A (en) 1998-07-10 2000-08-22 Sulzer Carbomedics Inc. Implantable attaching ring
US7569062B1 (en) 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
AU5548699A (en) 1998-08-06 2000-02-28 Michael A. Gambale Surgical screw cartridge, screw holder/magazine and pistol-type screwdriver for bone fixation
US6210347B1 (en) 1998-08-13 2001-04-03 Peter Forsell Remote control food intake restriction device
US6159240A (en) 1998-08-31 2000-12-12 Medtronic, Inc. Rigid annuloplasty device that becomes compliant after implantation
FR2783153B1 (fr) 1998-09-14 2000-12-01 Jerome Dargent Dispositif de constriction gastrique
CA2344252A1 (en) 1998-09-18 2000-03-30 United States Surgical Corporation Endovascular fastener applicator
US6355030B1 (en) 1998-09-25 2002-03-12 Cardiothoracic Systems, Inc. Instruments and methods employing thermal energy for the repair and replacement of cardiac valves
US6102945A (en) 1998-10-16 2000-08-15 Sulzer Carbomedics, Inc. Separable annuloplasty ring
US9521999B2 (en) 2005-09-13 2016-12-20 Arthrex, Inc. Fully-threaded bioabsorbable suture anchor
US6315784B1 (en) 1999-02-03 2001-11-13 Zarija Djurovic Surgical suturing unit
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
DE19910233A1 (de) 1999-03-09 2000-09-21 Jostra Medizintechnik Ag Anuloplastieprothese
US6319281B1 (en) 1999-03-22 2001-11-20 Kumar R. Patel Artificial venous valve and sizing catheter
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
ATE484241T1 (de) 1999-04-09 2010-10-15 Evalve Inc Verfahren und vorrichtung zur herzklappenreperation
WO2006116558A2 (en) 1999-04-09 2006-11-02 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6183512B1 (en) 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US20050222665A1 (en) 1999-04-23 2005-10-06 Ernest Aranyi Endovascular fastener applicator
US6674993B1 (en) 1999-04-30 2004-01-06 Microvision, Inc. Method and system for identifying data locations associated with real world observations
US6187040B1 (en) 1999-05-03 2001-02-13 John T. M. Wright Mitral and tricuspid annuloplasty rings
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6602289B1 (en) 1999-06-08 2003-08-05 S&A Rings, Llc Annuloplasty rings of particular use in surgery for the mitral valve
US6626899B2 (en) 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
SE514718C2 (sv) 1999-06-29 2001-04-09 Jan Otto Solem Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten
US6997951B2 (en) 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6592609B1 (en) 1999-08-09 2003-07-15 Bonutti 2003 Trust-A Method and apparatus for securing tissue
US8500795B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable devices for improving cardiac function
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
JP3553432B2 (ja) 1999-09-24 2004-08-11 本田技研工業株式会社 ライディングシミュレーション装置
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
AU1233301A (en) 1999-10-26 2001-05-08 H. Randall Craig Helical suture instrument
AUPQ366099A0 (en) 1999-10-26 1999-11-18 Queensland University Of Technology Ortho paedic screw
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6926730B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Minimally invasive valve repair procedure and apparatus
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US6911032B2 (en) 1999-11-18 2005-06-28 Scimed Life Systems, Inc. Apparatus and method for compressing body tissue
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
US6494908B1 (en) 1999-12-22 2002-12-17 Ethicon, Inc. Removable stent for body lumens
US7169187B2 (en) 1999-12-22 2007-01-30 Ethicon, Inc. Biodegradable stent
CN1806775A (zh) 2000-01-14 2006-07-26 维亚科公司 组织瓣环成形术带
US6989028B2 (en) * 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US7507252B2 (en) 2000-01-31 2009-03-24 Edwards Lifesciences Ag Adjustable transluminal annuloplasty system
US6458076B1 (en) 2000-02-01 2002-10-01 5 Star Medical Multi-lumen medical device
US20050070999A1 (en) 2000-02-02 2005-03-31 Spence Paul A. Heart valve repair apparatus and methods
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
US6461336B1 (en) 2000-02-08 2002-10-08 LARRé JORGE CASADO Cardiological medical equipment
US6470892B1 (en) 2000-02-10 2002-10-29 Obtech Medical Ag Mechanical heartburn and reflux treatment
EP1284691B1 (en) 2000-02-11 2006-12-20 Potencia Medical AG Urinary incontinence treatment apparatus
US7993368B2 (en) 2003-03-13 2011-08-09 C.R. Bard, Inc. Suture clips, delivery devices and methods
US6569198B1 (en) 2000-03-31 2003-05-27 Richard A. Wilson Mitral or tricuspid valve annuloplasty prosthetic device
US6689125B1 (en) 2000-04-04 2004-02-10 Spinalabs, Llc Devices and methods for the treatment of spinal disorders
US6533772B1 (en) 2000-04-07 2003-03-18 Innex Corporation Guide wire torque device
US6368348B1 (en) 2000-05-15 2002-04-09 Shlomo Gabbay Annuloplasty prosthesis for supporting an annulus of a heart valve
US7220266B2 (en) 2000-05-19 2007-05-22 C. R. Bard, Inc. Tissue capturing and suturing device and method
NZ522752A (en) 2000-05-25 2004-08-27 Bioring S Device for shrinking or reinforcing the heart valvular orifices
US6406493B1 (en) 2000-06-02 2002-06-18 Hosheng Tu Expandable annuloplasty ring and methods of use
US6805711B2 (en) 2000-06-02 2004-10-19 3F Therapeutics, Inc. Expandable medical implant and percutaneous delivery
US7632303B1 (en) 2000-06-07 2009-12-15 Advanced Cardiovascular Systems, Inc. Variable stiffness medical devices
EP1330189B1 (en) 2000-06-23 2007-12-19 Viacor Incorporated Automated annular plication for mitral valve repair
US7144414B2 (en) 2000-06-27 2006-12-05 Smith & Nephew, Inc. Surgical procedures and instruments
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US6613078B1 (en) 2000-08-02 2003-09-02 Hector Daniel Barone Multi-component endoluminal graft assembly, use thereof and method of implanting
SE0002878D0 (sv) 2000-08-11 2000-08-11 Kimblad Ola Device and method for treatment of atrioventricular regurgitation
US6524338B1 (en) 2000-08-25 2003-02-25 Steven R. Gundry Method and apparatus for stapling an annuloplasty band in-situ
US6554845B1 (en) 2000-09-15 2003-04-29 PARÉ Surgical, Inc. Suturing apparatus and method
US20090287179A1 (en) 2003-10-01 2009-11-19 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US8784482B2 (en) 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US7381220B2 (en) 2000-09-20 2008-06-03 Ample Medical, Inc. Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US20080091264A1 (en) 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US6893459B1 (en) 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US20060106278A1 (en) 2004-05-14 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of an adjustable bridge implant system
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6918917B1 (en) 2000-10-10 2005-07-19 Medtronic, Inc. Minimally invasive annuloplasty procedure and apparatus
US20020082525A1 (en) 2000-10-18 2002-06-27 Oslund John C. Rapid exchange delivery catheter
US6913608B2 (en) 2000-10-23 2005-07-05 Viacor, Inc. Automated annular plication for mitral valve repair
US6527780B1 (en) 2000-10-31 2003-03-04 Odyssey Medical, Inc. Medical implant insertion system
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
US6579300B2 (en) 2001-01-18 2003-06-17 Scimed Life Systems, Inc. Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy
US7510576B2 (en) 2001-01-30 2009-03-31 Edwards Lifesciences Ag Transluminal mitral annuloplasty
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
JP4097924B2 (ja) 2001-02-05 2008-06-11 オリンパス株式会社 生体組織のクリップ装置
AU2002243851A1 (en) 2001-02-05 2002-08-19 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
US6610080B2 (en) 2001-02-28 2003-08-26 Axya Medical, Inc. Parabolic eyelet suture anchor
US6786924B2 (en) 2001-03-15 2004-09-07 Medtronic, Inc. Annuloplasty band and method
US7186264B2 (en) 2001-03-29 2007-03-06 Viacor, Inc. Method and apparatus for improving mitral valve function
CN1318105C (zh) 2001-04-02 2007-05-30 霍克研究基金会 顺应性的无气囊导管
DE10119096A1 (de) 2001-04-19 2002-10-24 Keramed Medizintechnik Gmbh Biologisch funktionalisierte, metabolisch induktive Implantatoberflächen
US8202315B2 (en) 2001-04-24 2012-06-19 Mitralign, Inc. Catheter-based annuloplasty using ventricularly positioned catheter
US20050125011A1 (en) 2001-04-24 2005-06-09 Spence Paul A. Tissue fastening systems and methods utilizing magnetic guidance
US7037334B1 (en) 2001-04-24 2006-05-02 Mitralign, Inc. Method and apparatus for catheter-based annuloplasty using local plications
US20060069429A1 (en) 2001-04-24 2006-03-30 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US6619291B2 (en) 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US6682558B2 (en) 2001-05-10 2004-01-27 3F Therapeutics, Inc. Delivery system for a stentless valve bioprosthesis
US6858039B2 (en) 2002-07-08 2005-02-22 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
US7935145B2 (en) 2001-05-17 2011-05-03 Edwards Lifesciences Corporation Annuloplasty ring for ischemic mitral valve insuffuciency
ITMI20011012A1 (it) 2001-05-17 2002-11-17 Ottavio Alfieri Protesi anulare per valvola mitrale
FI114150B (fi) 2001-05-17 2004-08-31 Inion Ltd Kirurgisten kiinnitysvälineiden kiinnitysvälinevarasto ja sovitelma kirurgisten kiinnnitysvälineiden kiinnitysvälinevarastolle
US20020188301A1 (en) 2001-06-11 2002-12-12 Dallara Mark Douglas Tissue anchor insertion system
ATE278367T1 (de) 2001-06-11 2004-10-15 Sorin Biomedica Cardio Spa Annuloplastieprothese und herstellungsverfahren dafür
WO2002102237A2 (en) 2001-06-15 2002-12-27 The Cleveland Clinic Foundation Tissue engineered mitral valve chrodae and methods of making and using same
US6958079B1 (en) 2001-07-03 2005-10-25 Reflux Corporation Perorally insertable/removable anti-reflux valve
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US7150737B2 (en) 2001-07-13 2006-12-19 Sci/Med Life Systems, Inc. Methods and apparatuses for navigating the subarachnoid space
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
US6908482B2 (en) 2001-08-28 2005-06-21 Edwards Lifesciences Corporation Three-dimensional annuloplasty ring and template
US6749630B2 (en) 2001-08-28 2004-06-15 Edwards Lifesciences Corporation Tricuspid ring and template
EP1432369B1 (en) 2001-08-31 2008-02-27 Mitral Interventions Apparatus for valve repair
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20030050693A1 (en) 2001-09-10 2003-03-13 Quijano Rodolfo C. Minimally invasive delivery system for annuloplasty rings
AU2002362442B2 (en) 2001-10-01 2008-08-07 Ample Medical, Inc. Methods and devices for heart valve treatments
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
US20060020336A1 (en) 2001-10-23 2006-01-26 Liddicoat John R Automated annular plication for mitral valve repair
US7052487B2 (en) 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
GB0125925D0 (en) 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US6949122B2 (en) 2001-11-01 2005-09-27 Cardiac Dimensions, Inc. Focused compression mitral valve device and method
US7311729B2 (en) 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6805710B2 (en) 2001-11-13 2004-10-19 Edwards Lifesciences Corporation Mitral valve annuloplasty ring for molding left ventricle geometry
US20050177180A1 (en) 2001-11-28 2005-08-11 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
CN100479786C (zh) 2001-11-28 2009-04-22 阿普特斯内系统公司 血管内动脉瘤修复系统
US7147657B2 (en) 2003-10-23 2006-12-12 Aptus Endosystems, Inc. Prosthesis delivery systems and methods
US8231639B2 (en) 2001-11-28 2012-07-31 Aptus Endosystems, Inc. Systems and methods for attaching a prosthesis within a body lumen or hollow organ
US20090099650A1 (en) 2001-11-28 2009-04-16 Lee Bolduc Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US20030176914A1 (en) 2003-01-21 2003-09-18 Rabkin Dmitry J. Multi-segment modular stent and methods for manufacturing stents
WO2003047467A1 (en) 2001-12-04 2003-06-12 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template system
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6978176B2 (en) 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
DE10161543B4 (de) 2001-12-11 2004-02-19 REITAN, Öyvind Implantat zur Behandlung einer Insuffizienz einer Herzklappe
US6740107B2 (en) 2001-12-19 2004-05-25 Trimedyne, Inc. Device for treatment of atrioventricular valve regurgitation
US8123801B2 (en) 2001-12-21 2012-02-28 QuickRing Medical Technologies, Ltd. Implantation system for annuloplasty rings
WO2003053289A1 (en) 2001-12-21 2003-07-03 Simcha Milo Implantation system for annuloplasty rings
US20030120340A1 (en) 2001-12-26 2003-06-26 Jan Liska Mitral and tricuspid valve repair
SE524709C2 (sv) 2002-01-11 2004-09-21 Edwards Lifesciences Ag Anordning för fördröjd omformning av ett hjärtkärl och en hjärtklaff
EP2181668A1 (en) 2001-12-28 2010-05-05 Edwards Lifesciences AG Device for treating mitral annulus dilatation comprising a balloon catheter and a stent
US7033390B2 (en) 2002-01-02 2006-04-25 Medtronic, Inc. Prosthetic heart valve system
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
WO2003105670A2 (en) 2002-01-10 2003-12-24 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7717899B2 (en) 2002-01-28 2010-05-18 Cardiac Pacemakers, Inc. Inner and outer telescoping catheter delivery system
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US7118595B2 (en) 2002-03-18 2006-10-10 Medtronic, Inc. Flexible annuloplasty prosthesis and holder
US6719786B2 (en) 2002-03-18 2004-04-13 Medtronic, Inc. Flexible annuloplasty prosthesis and holder
EP2153799B1 (en) 2002-03-27 2011-08-03 Sorin Biomedica Cardio S.r.l. A prosthesis for annuloplasty comprising a perforated element
US20030199974A1 (en) 2002-04-18 2003-10-23 Coalescent Surgical, Inc. Annuloplasty apparatus and methods
EP1496807B1 (en) 2002-04-22 2017-01-04 Covidien LP Tack and tack applier
US6951565B2 (en) 2002-04-24 2005-10-04 Linvatec Biomaterials Ltd. Device for inserting surgical implants
US6764810B2 (en) 2002-04-25 2004-07-20 Taiwan Semiconductor Manufacturing Co., Ltd Method for dual-damascene formation using a via plug
US20030204193A1 (en) 2002-04-25 2003-10-30 Stefan Gabriel Suture anchor insertion tool
US7077850B2 (en) 2002-05-01 2006-07-18 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
AU2003225291A1 (en) 2002-05-10 2003-11-11 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
AU2003247526A1 (en) 2002-06-12 2003-12-31 Mitral Interventions, Inc. Method and apparatus for tissue connection
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7588582B2 (en) 2002-06-13 2009-09-15 Guided Delivery Systems Inc. Methods for remodeling cardiac tissue
US8641727B2 (en) 2002-06-13 2014-02-04 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20060122633A1 (en) 2002-06-13 2006-06-08 John To Methods and devices for termination
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20040243227A1 (en) 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7753922B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US7883538B2 (en) 2002-06-13 2011-02-08 Guided Delivery Systems Inc. Methods and devices for termination
US20060241656A1 (en) 2002-06-13 2006-10-26 Starksen Niel F Delivery devices and methods for heart valve repair
US6932834B2 (en) 2002-06-27 2005-08-23 Ethicon, Inc. Suture anchor
US7608103B2 (en) 2002-07-08 2009-10-27 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
IL150855A (en) 2002-07-22 2007-06-03 Leonid Monassevitch Intratubular anastomosis apparatus
US7993351B2 (en) 2002-07-24 2011-08-09 Pressure Products Medical Supplies, Inc. Telescopic introducer with a compound curvature for inducing alignment and method of using the same
US8292884B2 (en) 2002-08-01 2012-10-23 Levine Robert A Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
JP4929428B2 (ja) 2002-08-13 2012-05-09 ロバート・エー・レヴィン 房室弁の経皮的修復のための心臓デバイスおよび方法
ATE464028T1 (de) 2002-08-29 2010-04-15 St Jude Medical Cardiology Div Implantierbare vorrichtungen zur kontrolle des inneren durchmessers einer öffnung im körper
US8758372B2 (en) 2002-08-29 2014-06-24 St. Jude Medical, Cardiology Division, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
ES2291405T3 (es) 2002-09-04 2008-03-01 Endoart S.A. Anillo quirurgico provisto de un sistema de mando a distancia y reversible en la variacion de su diametro.
ATE538727T1 (de) 2002-09-09 2012-01-15 Brian Kelleher Vorrichtung zur endoluminalen therapie
US7883528B2 (en) 2002-09-12 2011-02-08 Arthrex, Inc. Fully threaded suture anchor with insert-molded suture
US20040059413A1 (en) 2002-09-20 2004-03-25 Claudio Argento Suture template for facilitating implantation of a prosthetic heart valve
WO2004028348A2 (en) 2002-09-26 2004-04-08 Savacor, Inc. Cardiovascular anchoring device and method of deploying same
ATE418938T1 (de) 2002-10-01 2009-01-15 Ample Medical Inc Vorrichtungen und systeme zur umformung eines herzklappen-annulus
US20040068273A1 (en) 2002-10-02 2004-04-08 Ibionics Corporation Automatic laparoscopic incision closing apparatus
US7087064B1 (en) 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
CN1705462A (zh) 2002-10-21 2005-12-07 米特拉利根公司 利用局部皱襞实施导管瓣环成形术的方法和装置
US20050119735A1 (en) 2002-10-21 2005-06-02 Spence Paul A. Tissue fastening systems and methods utilizing magnetic guidance
US6733536B1 (en) 2002-10-22 2004-05-11 Scimed Life Systems Male urethral stent device
US7112219B2 (en) 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7247134B2 (en) 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US8187324B2 (en) 2002-11-15 2012-05-29 Advanced Cardiovascular Systems, Inc. Telescoping apparatus for delivering and adjusting a medical device in a vessel
US7981152B1 (en) 2004-12-10 2011-07-19 Advanced Cardiovascular Systems, Inc. Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites
US7335213B1 (en) 2002-11-15 2008-02-26 Abbott Cardiovascular Systems Inc. Apparatus and methods for heart valve repair
WO2004045378A2 (en) 2002-11-15 2004-06-03 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method and device for catheter-based repair of cardiac valves
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US7108710B2 (en) 2002-11-26 2006-09-19 Abbott Laboratories Multi-element biased suture clip
US7608114B2 (en) 2002-12-02 2009-10-27 Gi Dynamics, Inc. Bariatric sleeve
US7316708B2 (en) 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US7316710B1 (en) 2002-12-30 2008-01-08 Advanced Cardiovascular Systems, Inc. Flexible stent
US6931338B2 (en) 2003-01-07 2005-08-16 Guide Technology, Inc. System for providing a calibrated path for multi-signal cables in testing of integrated circuits
US7314485B2 (en) 2003-02-03 2008-01-01 Cardiac Dimensions, Inc. Mitral valve device using conditioned shape memory alloy
US20040176788A1 (en) 2003-03-07 2004-09-09 Nmt Medical, Inc. Vacuum attachment system
US20040186566A1 (en) 2003-03-18 2004-09-23 Hindrichs Paul J. Body tissue remodeling methods and apparatus
US20050107871A1 (en) 2003-03-30 2005-05-19 Fidel Realyvasquez Apparatus and methods for valve repair
WO2004087017A1 (en) 2003-04-02 2004-10-14 Boston Scientific Limited Detachable and retrievable stent assembly
US7159593B2 (en) 2003-04-17 2007-01-09 3F Therapeutics, Inc. Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7862584B2 (en) 2003-05-07 2011-01-04 Anpa Medical, Inc. Suture lock
US20040230208A1 (en) 2003-05-13 2004-11-18 Vafa Shayani Article for positioning mesh over tissue
EP2298184A1 (en) 2003-06-13 2011-03-23 Tyco Healthcare Group LP Multiple member interconnect for surgical instrument and absorbable screw fastener
US7967850B2 (en) 2003-06-18 2011-06-28 Jackson Roger P Polyaxial bone anchor with helical capture connection, insert and dual locking assembly
US7316706B2 (en) 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US20040260394A1 (en) 2003-06-20 2004-12-23 Medtronic Vascular, Inc. Cardiac valve annulus compressor system
WO2004112585A2 (en) 2003-06-20 2004-12-29 Medtronic Vascular, Inc. Valve annulus reduction system
JP2007524460A (ja) 2003-06-25 2007-08-30 ジョージア テック リサーチ コーポレイション 弁輪形成チェーン
US8052751B2 (en) 2003-07-02 2011-11-08 Flexcor, Inc. Annuloplasty rings for repairing cardiac valves
CA2533020A1 (en) 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US20050016560A1 (en) 2003-07-21 2005-01-27 Dee Voughlohn Unique hair-styling system and method
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US20050049692A1 (en) 2003-09-02 2005-03-03 Numamoto Michael J. Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US20050075720A1 (en) 2003-10-06 2005-04-07 Nguyen Tuoc Tan Minimally invasive valve replacement system
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
US7226647B2 (en) 2003-10-16 2007-06-05 Hewlett-Packard Development Company, L.P. Permanent fixation of dyes to surface-modified inorganic particulate-coated media
US7004176B2 (en) 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US20060184242A1 (en) 2003-10-20 2006-08-17 Samuel Lichtenstein Method and apparatus for percutaneous reduction of anterior-posterior diameter of mitral valve
ITBO20030631A1 (it) 2003-10-23 2005-04-24 Roberto Erminio Parravicini Apparecchiatura protesica valvolare, in particolare per applicazioni cardiache.
US20050090827A1 (en) 2003-10-28 2005-04-28 Tewodros Gedebou Comprehensive tissue attachment system
CA2543680C (en) 2003-10-31 2012-05-22 Trudell Medical International System and method for manipulating a catheter for delivering a substance to a body cavity
WO2005046531A2 (en) 2003-11-12 2005-05-26 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
EP1689329A2 (en) * 2003-11-12 2006-08-16 Medtronic Vascular, Inc. Cardiac valve annulus reduction system
WO2005055883A1 (en) 2003-12-04 2005-06-23 The Brigham And Women's Hospital, Inc. Aortic valve annuloplasty rings
US20050177228A1 (en) 2003-12-16 2005-08-11 Solem Jan O. Device for changing the shape of the mitral annulus
US20050273138A1 (en) 2003-12-19 2005-12-08 Guided Delivery Systems, Inc. Devices and methods for anchoring tissue
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US7166127B2 (en) 2003-12-23 2007-01-23 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US8864822B2 (en) 2003-12-23 2014-10-21 Mitralign, Inc. Devices and methods for introducing elements into tissue
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7288115B2 (en) 2004-01-02 2007-10-30 Zimmer Technology, Inc. Multipart component for an orthopaedic implant
US20050159728A1 (en) 2004-01-15 2005-07-21 Thomas Medical Products, Inc. Steerable sheath
US20050159810A1 (en) 2004-01-15 2005-07-21 Farzan Filsoufi Devices and methods for repairing cardiac valves
US20050187568A1 (en) 2004-02-20 2005-08-25 Klenk Alan R. Devices and methods for closing a patent foramen ovale with a coil-shaped closure device
US8206439B2 (en) 2004-02-23 2012-06-26 International Heart Institute Of Montana Foundation Internal prosthesis for reconstruction of cardiac geometry
US20050203549A1 (en) 2004-03-09 2005-09-15 Fidel Realyvasquez Methods and apparatus for off pump aortic valve replacement with a valve prosthesis
US20050203606A1 (en) 2004-03-09 2005-09-15 Vancamp Daniel H. Stent system for preventing restenosis
EP2308425B2 (en) 2004-03-11 2023-10-18 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous Heart Valve Prosthesis
WO2005087139A1 (en) 2004-03-15 2005-09-22 Baker Medical Research Institute Treating valve failure
NL1025830C2 (nl) 2004-03-26 2005-02-22 Eric Berreklouw Samenstel omvattende een ring voor bevestiging in een door lichaamsweefsel omgeven doorgang alsmede een applicator voor het in de doorgang plaatsen van de ring.
US20050234481A1 (en) 2004-03-31 2005-10-20 Wilson-Cook Medical Inc. Suture cutting device
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
GB0407908D0 (en) 2004-04-07 2004-05-12 Univ York Ionic liquids
US7645293B2 (en) 2004-04-21 2010-01-12 United States Surgical Corporation Suture anchor installation system and method
US7294148B2 (en) 2004-04-29 2007-11-13 Edwards Lifesciences Corporation Annuloplasty ring for mitral valve prolapse
US7320704B2 (en) 2004-05-05 2008-01-22 Direct Flow Medical, Inc. Nonstented temporary valve for cardiovascular therapy
US7390329B2 (en) 2004-05-07 2008-06-24 Usgi Medical, Inc. Methods for grasping and cinching tissue anchors
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US20060122692A1 (en) 2004-05-10 2006-06-08 Ran Gilad Stent valve and method of using same
US20050256532A1 (en) 2004-05-12 2005-11-17 Asha Nayak Cardiovascular defect patch device and method
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
US7452376B2 (en) 2004-05-14 2008-11-18 St. Jude Medical, Inc. Flexible, non-planar annuloplasty rings
US7361190B2 (en) 2004-06-29 2008-04-22 Micardia Corporation Adjustable cardiac valve implant with coupling mechanism
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
US8012202B2 (en) 2004-07-27 2011-09-06 Alameddine Abdallah K Mitral valve ring for treatment of mitral valve regurgitation
US9061120B2 (en) 2004-08-05 2015-06-23 Oscor Inc. Catheter control mechanism and steerable catheter
US7126289B2 (en) 2004-08-20 2006-10-24 O2 Micro Inc Protection for external electrode fluorescent lamp system
JP2008513060A (ja) 2004-09-14 2008-05-01 エドワーズ ライフサイエンシーズ アーゲー 心臓弁逆流の処置のためのデバイスおよび方法
CA2748617C (en) 2004-09-27 2014-09-23 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US20060085012A1 (en) 2004-09-28 2006-04-20 Medtronic Vascular, Inc. Torquing device delivered over a guidewire to rotate a medical fastener
JP5393980B2 (ja) 2004-09-28 2014-01-22 サージカル ソリューションズ リミテッド ライアビリティ カンパニー 縫合糸アンカー
US20070083168A1 (en) 2004-09-30 2007-04-12 Whiting James S Transmembrane access systems and methods
WO2006041877A2 (en) 2004-10-05 2006-04-20 Ample Medical, Inc. Atrioventricular valve annulus repair systems and methods including retro-chordal anchors
US7470256B2 (en) 2004-10-29 2008-12-30 Merit Medical Systems, Inc., Self-suturing anchor device for a catheter
CN100475165C (zh) 2004-12-07 2009-04-08 奥林巴斯株式会社 用于内窥镜的处理装置系统和包括处理装置的壳
EP1841383A1 (en) 2004-12-15 2007-10-10 Mednua Limited A medical device suitable for use in treatment of a valve
WO2006066114A1 (en) 2004-12-15 2006-06-22 Cook Urological Incorporated Radiopaque manipulation devices
US7691095B2 (en) 2004-12-28 2010-04-06 St. Jude Medical, Atrial Fibrillation Division, Inc. Bi-directional steerable catheter control handle
US7869865B2 (en) 2005-01-07 2011-01-11 Biosense Webster, Inc. Current-based position sensing
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
AU2006212750B2 (en) 2005-02-07 2011-11-17 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US20100298929A1 (en) 2005-02-07 2010-11-25 Thornton Troy L Methods, systems and devices for cardiac valve repair
EP2174584B1 (en) 2005-02-08 2012-05-02 Koninklijke Philips Electronics N.V. System for percutaneous glossoplasty
US8220466B2 (en) 2005-02-08 2012-07-17 Koninklijke Philips Electronics N.V. System and method for percutaneous palate remodeling
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
US20060206203A1 (en) 2005-03-10 2006-09-14 Jun Yang Valvular support prosthesis
WO2006097931A2 (en) 2005-03-17 2006-09-21 Valtech Cardio, Ltd. Mitral valve treatment techniques
US8906039B2 (en) 2005-03-21 2014-12-09 Design Standards Corporation Suturing device
US8608726B2 (en) 2005-03-24 2013-12-17 The Cleveland Clinic Foundation Vascular guidewire control apparatus
US8265758B2 (en) 2005-03-24 2012-09-11 Metacure Limited Wireless leads for gastrointestinal tract applications
WO2007080595A2 (en) 2006-01-12 2007-07-19 Metacure N.V. Electrode assemblies, tools, and methods for gastric wall implantation
US8864823B2 (en) 2005-03-25 2014-10-21 StJude Medical, Cardiology Division, Inc. Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
EP1861045B1 (en) 2005-03-25 2015-03-04 St. Jude Medical, Cardiology Division, Inc. Apparatus for controlling the internal circumference of an anatomic orifice or lumen
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
EP1893131A1 (en) 2005-04-20 2008-03-05 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US8333777B2 (en) 2005-04-22 2012-12-18 Benvenue Medical, Inc. Catheter-based tissue remodeling devices and methods
US7758594B2 (en) 2005-05-20 2010-07-20 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US7500989B2 (en) 2005-06-03 2009-03-10 Edwards Lifesciences Corp. Devices and methods for percutaneous repair of the mitral valve via the coronary sinus
US20060287716A1 (en) 2005-06-08 2006-12-21 The Cleveland Clinic Foundation Artificial chordae
US7618413B2 (en) 2005-06-22 2009-11-17 Boston Scientific Scimed, Inc. Medical device control system
US8951285B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor, anchoring system and methods of using the same
US20070162111A1 (en) 2005-07-06 2007-07-12 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
US20070016288A1 (en) 2005-07-13 2007-01-18 Gurskis Donnell W Two-piece percutaneous prosthetic heart valves and methods for making and using them
DE102006017873A1 (de) 2005-07-14 2007-01-25 Qualimed Innovative Medizinprodukte Gmbh Temporärer Stent
US7927371B2 (en) 2005-07-15 2011-04-19 The Cleveland Clinic Foundation Apparatus and method for reducing cardiac valve regurgitation
DE602006009113D1 (de) 2005-07-15 2009-10-22 Cleveland Clinic Foundation Vorrichtung zur Ummodellierung eines Herzklappenrings
US7875056B2 (en) 2005-07-22 2011-01-25 Anpa Medical, Inc. Wedge operated retainer device and methods
US20070027533A1 (en) 2005-07-28 2007-02-01 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
US7749247B2 (en) 2005-08-04 2010-07-06 St. Jude Medical Puerto Rico, Llc Tissue puncture closure device with coiled automatic tamping system
US20070055206A1 (en) 2005-08-10 2007-03-08 Guided Delivery Systems, Inc. Methods and devices for deployment of tissue anchors
US7222559B2 (en) 2005-08-16 2007-05-29 Chun Fu Wang Screwdriver with torque setting mechanism
US9492277B2 (en) 2005-08-30 2016-11-15 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
US20070078297A1 (en) 2005-08-31 2007-04-05 Medtronic Vascular, Inc. Device for Treating Mitral Valve Regurgitation
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US20070061010A1 (en) 2005-09-09 2007-03-15 Hauser David L Device and method for reshaping mitral valve annulus
CA2561034C (en) 2005-09-30 2014-12-09 Sherwood Services Ag Flexible endoscopic catheter with an end effector for coagulating and transfecting tissue
US20070083235A1 (en) 2005-10-11 2007-04-12 Jervis James E Helical retainer, tool for using the helical retainer, and methods
US7695510B2 (en) 2005-10-11 2010-04-13 Medtronic Vascular, Inc. Annuloplasty device having shape-adjusting tension filaments
CN101466316B (zh) 2005-10-20 2012-06-27 阿普特斯内系统公司 包括使用固定件工具的用于修复物递送和植入的装置、系统和方法
US8216302B2 (en) 2005-10-26 2012-07-10 Cardiosolutions, Inc. Implant delivery and deployment system and method
WO2007053592A2 (en) 2005-10-31 2007-05-10 Cook Incorporated Composite stent graft
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
WO2007056590A1 (en) 2005-11-08 2007-05-18 Trustees Of Boston University Manipulators employing multiple deformable elongate members
ATE429194T1 (de) 2005-11-16 2009-05-15 Micardia Corp Magnetische befestigung eines katheters an ein implantat
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070118151A1 (en) 2005-11-21 2007-05-24 The Brigham And Women's Hospital, Inc. Percutaneous cardiac valve repair with adjustable artificial chordae
US8043368B2 (en) 2005-11-23 2011-10-25 Traves Dean Crabtree Methods and apparatus for atrioventricular valve repair
US7632308B2 (en) 2005-11-23 2009-12-15 Didier Loulmet Methods, devices, and kits for treating mitral valve prolapse
FR2894131B1 (fr) 2005-12-02 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un vaisseau sanguin, et necessaire de traitement associe.
CA2669188C (en) 2005-12-15 2014-08-05 Georgia Tech Research Corporation Papillary muscle position control devices, systems, & methods
WO2007078772A1 (en) 2005-12-15 2007-07-12 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant valve
US20070142907A1 (en) 2005-12-16 2007-06-21 Micardia Corporation Adjustable prosthetic valve implant
EP1803420B1 (en) 2005-12-28 2009-07-01 Sorin Biomedica Cardio S.R.L. Annuloplasty prosthesis with an auxetic structure
EP2012677B1 (de) 2006-02-28 2011-11-16 Bard Shannon Limited Vorrichtung zum setzen von befestigungsankern in das menschliche oder tierische gewebe
US7635386B1 (en) 2006-03-07 2009-12-22 University Of Maryland, Baltimore Methods and devices for performing cardiac valve repair
US7431692B2 (en) 2006-03-09 2008-10-07 Edwards Lifesciences Corporation Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
US20070219558A1 (en) 2006-03-15 2007-09-20 Allen Deutsch Method and apparatus for arthroscopic surgery using suture anchors
WO2007110866A2 (en) 2006-03-28 2007-10-04 Spatz-Fgia Inc Floating gastrointestinal anchor
US20090254103A1 (en) 2006-03-29 2009-10-08 Deutsch Harvey L Method and device for cavity obliteration
US7625403B2 (en) 2006-04-04 2009-12-01 Medtronic Vascular, Inc. Valved conduit designed for subsequent catheter delivered valve therapy
US20070239208A1 (en) 2006-04-05 2007-10-11 Crawford Bruce S Surgical implantation device and method
US7699892B2 (en) 2006-04-12 2010-04-20 Medtronic Vascular, Inc. Minimally invasive procedure for implanting an annuloplasty device
US20070244556A1 (en) 2006-04-12 2007-10-18 Medtronic Vascular, Inc. Annuloplasty Device Having a Helical Anchor and Methods for its Use
US7442207B2 (en) 2006-04-21 2008-10-28 Medtronic Vascular, Inc. Device, system, and method for treating cardiac valve regurgitation
US20070270755A1 (en) 2006-04-21 2007-11-22 Abbott Laboratories Guidewire handling device
US8551161B2 (en) 2006-04-25 2013-10-08 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
US7862582B2 (en) 2006-05-02 2011-01-04 Ethicon Endo-Surgery, Inc. Suture management
US9101338B2 (en) 2006-05-03 2015-08-11 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
ATE499074T1 (de) 2006-05-15 2011-03-15 Edwards Lifesciences Ag System zur veränderung der geometrie des herzens
US20080091169A1 (en) 2006-05-16 2008-04-17 Wayne Heideman Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires
US20080234660A2 (en) 2006-05-16 2008-09-25 Sarah Cumming Steerable Catheter Using Flat Pull Wires and Method of Making Same
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
US8105355B2 (en) 2006-05-18 2012-01-31 C.R. Bard, Inc. Suture lock fastening device
WO2007137228A2 (en) 2006-05-19 2007-11-29 Norman Godin Medical staple, system and methods of use
JP2009538215A (ja) 2006-05-25 2009-11-05 ミトラリグン・インコーポレーテッド 外科用緊張部材のためのロッカーおよび外科用緊張部材を固定するためのその使用方法
EP2032080B1 (en) 2006-06-01 2017-05-03 Edwards Lifesciences Corporation Prosthetic insert for improving heart valve function
ITTO20060413A1 (it) 2006-06-07 2007-12-08 Arrigo Lessana Dispositivo sostitutivo delle corde tendinee di una valvola atrioventricolare
WO2007146325A2 (en) 2006-06-14 2007-12-21 Optivia Medical Llc Medical device introduction systems and methods
US7934506B2 (en) 2006-06-21 2011-05-03 Koninklijke Philips Electronics N.V. System and method for temporary tongue suspension
US20070295172A1 (en) 2006-06-23 2007-12-27 Darian Swartz Fastener Holding Device
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US7955315B2 (en) 2006-07-24 2011-06-07 Ethicon, Inc. Articulating laparoscopic device and method for delivery of medical fluid
US9750492B2 (en) 2006-08-04 2017-09-05 Depuy Mitek, Llc Suture anchor system with tension relief mechanism
US8430926B2 (en) 2006-08-11 2013-04-30 Japd Consulting Inc. Annuloplasty with enhanced anchoring to the annulus based on tissue healing
EP2056750A2 (en) 2006-08-14 2009-05-13 BUCH, Wally S. Methods and apparatus for mitral valve repair
CA2976839C (en) 2006-09-08 2020-04-28 Edwards Lifesciences Corporation Integrated heart valve delivery system
US8876894B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Leaflet-sensitive valve fixation member
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
US7674276B2 (en) 2006-10-06 2010-03-09 Biomet Sports Medicine, Llc Rotational securing of a suture
US7879087B2 (en) 2006-10-06 2011-02-01 Edwards Lifesciences Corporation Mitral and tricuspid annuloplasty rings
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
US20080103572A1 (en) 2006-10-31 2008-05-01 Medtronic, Inc. Implantable medical lead with threaded fixation
AU2007330338A1 (en) * 2006-12-05 2008-06-12 Valtech Cardio, Ltd. Segmented ring placement
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
JP5443169B2 (ja) 2007-01-03 2014-03-19 ミトラル・ソリューションズ・インコーポレイテッド 解剖学的構造又は内腔のサイズ及び形状を制御するための移植可能な装置
US9192471B2 (en) 2007-01-08 2015-11-24 Millipede, Inc. Device for translumenal reshaping of a mitral valve annulus
US20100249920A1 (en) 2007-01-08 2010-09-30 Millipede Llc Reconfiguring heart features
US20080177380A1 (en) 2007-01-19 2008-07-24 Starksen Niel F Methods and devices for heart tissue repair
EP2114304B1 (en) 2007-02-14 2017-09-06 Edwards Lifesciences Corporation implantable medical device for repairing heart
WO2008101228A2 (en) 2007-02-15 2008-08-21 Hansen Medical, Inc. Robotic medical instrument system
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
EP2120753B1 (en) 2007-03-05 2022-09-28 Tornier, Inc. Tack anchor systems
US20080228265A1 (en) 2007-03-13 2008-09-18 Mitralign, Inc. Tissue anchors, systems and methods, and devices
US8911461B2 (en) 2007-03-13 2014-12-16 Mitralign, Inc. Suture cutter and method of cutting suture
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US8303622B2 (en) 2007-03-14 2012-11-06 St. Jude Medical, Inc. Heart valve chordae replacement methods and apparatus
US9387308B2 (en) 2007-04-23 2016-07-12 Cardioguidance Biomedical, Llc Guidewire with adjustable stiffness
US9155452B2 (en) 2007-04-27 2015-10-13 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
US8529620B2 (en) 2007-05-01 2013-09-10 Ottavio Alfieri Inwardly-bowed tricuspid annuloplasty ring
US7931660B2 (en) 2007-05-10 2011-04-26 Tyco Healthcare Group Lp Powered tacker instrument
EP4233962B1 (en) 2007-05-18 2025-11-05 Boston Scientific Scimed, Inc. Medical drive systems
US8740937B2 (en) 2007-05-31 2014-06-03 Cook Medical Technologies Llc Suture lock
US20080300537A1 (en) 2007-06-03 2008-12-04 David Allen Bowman Method and system for steering a catheter end in multiple planes
US7771416B2 (en) 2007-06-14 2010-08-10 Ethicon Endo-Surgery, Inc. Control mechanism for flexible endoscopic device and method of use
ES2475144T3 (es) 2007-06-26 2014-07-10 St. Jude Medical, Inc. Aparato para la implantación de válvulas prot�sicas de corazón replegables / expansibles
US7914515B2 (en) 2007-07-18 2011-03-29 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter and introducer catheter having torque transfer layer and method of manufacture
US8388519B2 (en) 2007-07-26 2013-03-05 Sri International Controllable dexterous endoscopic device
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US9814611B2 (en) 2007-07-31 2017-11-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
CA2698388C (en) 2007-09-07 2015-11-24 Edwards Lifesciences Corporation Active holder for annuloplasty ring delivery
US8469983B2 (en) 2007-09-20 2013-06-25 Sentreheart, Inc. Devices and methods for remote suture management
US20090088837A1 (en) 2007-09-28 2009-04-02 The Cleveland Clinic Foundation Prosthetic chordae assembly and method of use
US8454686B2 (en) 2007-09-28 2013-06-04 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
WO2009045334A1 (en) 2007-09-28 2009-04-09 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
CA2702672C (en) 2007-10-15 2016-03-15 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
EP2222232B1 (en) 2007-10-19 2018-12-12 Ancora Heart, Inc. Devices for locking and/or cutting tethers
US20090105816A1 (en) 2007-10-19 2009-04-23 Olsen Daniel H System using a helical retainer in the direct plication annuloplasty treatment of mitral valve regurgitation
US9125632B2 (en) 2007-10-19 2015-09-08 Guided Delivery Systems, Inc. Systems and methods for cardiac remodeling
US8431057B2 (en) 2007-12-30 2013-04-30 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter shaft and method of its manufacture
US8349002B2 (en) 2008-01-16 2013-01-08 QuickRing Medical Technologies, Ltd. Adjustable annuloplasty rings
WO2009094373A1 (en) 2008-01-22 2009-07-30 Cook Incorporated Valve frame
AU2009212393B2 (en) 2008-02-06 2014-07-24 Ancora Heart, Inc. Multi-window guide tunnel
US8728097B1 (en) 2008-02-26 2014-05-20 Mitralign, Inc. Tissue plication devices and methods for their use
WO2009114316A2 (en) 2008-03-03 2009-09-17 Alaska Hand Research, Llc Cannulated anchor and system
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
US20090248148A1 (en) 2008-03-25 2009-10-01 Ellipse Technologies, Inc. Systems and methods for adjusting an annuloplasty ring with an integrated magnetic drive
US20100121435A1 (en) 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Percutaneous transvalvular intrannular band for mitral valve repair
US8262725B2 (en) 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
US20100121437A1 (en) 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy
FR2930137B1 (fr) 2008-04-18 2010-04-23 Corevalve Inc Materiel de traitement d'une valve cardiaque, en particulier d'une valve mitrale.
WO2009130631A2 (en) 2008-04-21 2009-10-29 Simcha Milo Surgical stapling systems
DK3967274T4 (da) 2008-04-23 2025-08-25 Medtronic Inc Hjerteklapanordninger med stent
US8152844B2 (en) 2008-05-09 2012-04-10 Edwards Lifesciences Corporation Quick-release annuloplasty ring holder
WO2009140298A2 (en) 2008-05-12 2009-11-19 Wright John T M Device and method for the surgical treatment of ischemic mitral regurgitation
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
GB0809357D0 (en) 2008-05-22 2008-07-02 Punjabi Prakash Heart valve repair device
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
CA2728078A1 (en) 2008-06-16 2010-01-14 Valtech Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US8087142B2 (en) 2008-07-02 2012-01-03 Easylap Ltd. Pivoting tacker
EP2321069B1 (en) 2008-07-04 2017-11-01 Tata Steel UK Limited Method for coating a steel substrate, and coated steel substrate
US20100010538A1 (en) 2008-07-11 2010-01-14 Maquet Cardiovascular Llc Reshaping the mitral valve of a heart
AT507113B1 (de) 2008-07-17 2010-07-15 Siemens Vai Metals Tech Gmbh Verfahren und anlage zur energie- und co2-emissionsoptimierten eisenerzeugung
AU2009274131B2 (en) 2008-07-21 2015-06-04 Jennifer K. White Repositionable endoluminal support structure and its applications
US20100023118A1 (en) 2008-07-24 2010-01-28 Edwards Lifesciences Corporation Method and apparatus for repairing or replacing chordae tendinae
BRPI0916696A2 (pt) 2008-07-29 2015-11-17 St Jude Medical Cardiology Div método e sistema para ajuste a longo prazo de um dispositivo de implante
US8337390B2 (en) * 2008-07-30 2012-12-25 Cube S.R.L. Intracardiac device for restoring the functional elasticity of the cardiac structures, holding tool for the intracardiac device, and method for implantation of the intracardiac device in the heart
US8778016B2 (en) 2008-08-14 2014-07-15 Edwards Lifesciences Corporation Method and apparatus for repairing or replacing chordae tendinae
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US8777990B2 (en) 2008-09-08 2014-07-15 Howmedica Osteonics Corp. Knotless suture anchor for soft tissue repair and method of use
US9408649B2 (en) 2008-09-11 2016-08-09 Innovasis, Inc. Radiolucent screw with radiopaque marker
US8945211B2 (en) 2008-09-12 2015-02-03 Mitralign, Inc. Tissue plication device and method for its use
US8287591B2 (en) 2008-09-19 2012-10-16 Edwards Lifesciences Corporation Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
CN102292053A (zh) 2008-09-29 2011-12-21 卡迪尔克阀门技术公司 心脏瓣膜
CN102245109A (zh) 2008-10-10 2011-11-16 导向传输系统股份有限公司 终止装置和相关方法
CA2740245C (en) 2008-10-10 2015-04-28 Guided Delivery Systems, Inc. Tether tensioning devices and related methods
JP5607639B2 (ja) 2008-10-10 2014-10-15 サドラ メディカル インコーポレイテッド 医療用デバイス・システム
CA2740867C (en) 2008-10-16 2018-06-12 Aptus Endosystems, Inc. Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US8696717B2 (en) 2008-11-05 2014-04-15 K2M, Inc. Multi-planar, taper lock screw with additional lock
DE102008058894B3 (de) 2008-11-26 2010-06-17 Vimecon Gmbh Laserapplikator
AU2009319897B2 (en) 2008-11-26 2015-11-26 Smith & Nephew, Inc. Tissue repair device
US8449573B2 (en) 2008-12-05 2013-05-28 Boston Scientific Scimed, Inc. Insertion device and method for delivery of a mesh carrier
CN101925474B (zh) 2008-12-19 2013-04-03 松下电器产业株式会社 外装零部件及其制造方法、以及电子设备
US8147542B2 (en) 2008-12-22 2012-04-03 Valtech Cardio, Ltd. Adjustable repair chords and spool mechanism therefor
US8241351B2 (en) * 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
EP3848002A1 (en) 2008-12-22 2021-07-14 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8926697B2 (en) 2011-06-23 2015-01-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US20110011917A1 (en) 2008-12-31 2011-01-20 Hansen Medical, Inc. Methods, devices, and kits for treating valve prolapse
EP2381895B1 (en) 2008-12-31 2021-07-07 Medtronic, Inc. Semi-rigid annuloplasty ring and band and method of making an annuloplasty ring
US9204965B2 (en) 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
WO2010085456A1 (en) 2009-01-20 2010-07-29 Guided Delivery Systems Inc. Anchor deployment devices and related methods
AU2010206658A1 (en) 2009-01-22 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Magnetic docking system and method for the long term adjustment of an implantable device
EP2389121B1 (en) 2009-01-22 2020-10-07 St. Jude Medical, Cardiology Division, Inc. Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
EP2393449B1 (en) 2009-02-06 2016-09-07 St. Jude Medical, Inc. Support for adjustable annuloplasty ring
AU2010210404A1 (en) 2009-02-09 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Inflatable minimally invasive system for delivering and securing an annular implant
EP2395923A1 (en) 2009-02-16 2011-12-21 Tigenix N.V. Biopsy device
US8353956B2 (en) 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US8725228B2 (en) 2009-02-20 2014-05-13 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
EP2401515B1 (en) 2009-02-24 2015-12-02 Flex Technology, Inc. Flexible screw
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
WO2010098857A1 (en) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
CN102405022B (zh) 2009-03-14 2015-02-04 瓦索斯蒂奇股份有限公司 血管进入和闭合装置
US20100249497A1 (en) 2009-03-30 2010-09-30 Peine William J Surgical instrument
CN101919753A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 人工主动脉瓣膜或二尖瓣膜的无缝合移植方法和装置
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
EP3081195B1 (en) 2009-04-10 2018-10-03 Lon Sutherland Annest An implantable scaffolding containing an orifice for use with a prosthetic or bio-prosthetic valve
US20100262233A1 (en) 2009-04-12 2010-10-14 Texas Tech University System Mitral Valve Coaptation Plate For Mitral Valve Regurgitation
AU2010236288A1 (en) 2009-04-15 2011-10-20 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
AU2010242820B2 (en) 2009-05-01 2014-12-11 Cayenne Medical, Inc. Meniscal repair systems and methods
US9968452B2 (en) * 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US20100286628A1 (en) 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
JP2012531240A (ja) 2009-06-26 2012-12-10 クイックリング メディカル テクノロジーズ リミテッド 外科用ステープラーおよび外科用ステープリングの方法
CA2767035C (en) 2009-07-02 2015-07-21 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US10136884B2 (en) 2009-07-17 2018-11-27 Pivot Medical, Inc. Method and apparatus for attaching tissue to bone, including the provision and use of a novel knotless suture anchor system, including a retractable sheath
KR101116867B1 (ko) 2009-08-28 2012-03-06 김준홍 관상정맥동과 삼천판막의 조직보호기구, 매듭 전달 기구 및 이들을 포함하는 승모판막 서클라지 시술용 장치
CN102647957B (zh) 2009-09-11 2015-04-29 Gi动力公司 具有张开头部的锚固器
US8459302B2 (en) 2009-09-21 2013-06-11 Gulf Sea Ventures LLC Fluid-directing multiport rotary valve
US8652203B2 (en) 2010-09-23 2014-02-18 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
WO2011041571A2 (en) 2009-10-01 2011-04-07 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
WO2011044486A1 (en) 2009-10-09 2011-04-14 Boston Scientific Scimed, Inc. Stomach bypass for the treatment of obesity
US20110093002A1 (en) 2009-10-20 2011-04-21 Wilson-Cook Medical Inc. Stent-within-stent arrangements
US8277502B2 (en) 2009-10-29 2012-10-02 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
WO2011154942A2 (en) 2010-06-07 2011-12-15 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of a rotation assembly
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US8734467B2 (en) 2009-12-02 2014-05-27 Valtech Cardio, Ltd. Delivery tool for implantation of spool assembly coupled to a helical anchor
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US20110144576A1 (en) 2009-12-14 2011-06-16 Voyage Medical, Inc. Catheter orientation control system mechanisms
US20110230961A1 (en) 2010-01-05 2011-09-22 Micardia Corporation Dynamically adjustable annuloplasty ring and papillary muscle repositioning suture
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
GB201001075D0 (en) 2010-01-22 2010-03-10 Cyclacel Ltd Crystalline forms
EP2531143B1 (en) 2010-02-03 2018-01-17 Medtronic GBI, Inc. Semi-flexible annuloplasty ring
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8357195B2 (en) 2010-04-15 2013-01-22 Medtronic, Inc. Catheter based annuloplasty system and method
US9795482B2 (en) 2010-04-27 2017-10-24 Medtronic, Inc. Prosthetic heart valve devices and methods of valve repair
US20110288435A1 (en) 2010-05-19 2011-11-24 George Michael Christy Tactile sensory testing instrument
US8790394B2 (en) 2010-05-24 2014-07-29 Valtech Cardio, Ltd. Adjustable artificial chordeae tendineae with suture loops
US20130030522A1 (en) 2010-06-16 2013-01-31 Rowe Stanton J Devices and methods for heart treatments
US9095277B2 (en) 2010-07-09 2015-08-04 Mitralign, Inc. Delivery catheter with forward-looking ultrasound imaging
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8518107B2 (en) 2010-08-04 2013-08-27 Valcare, Inc. Percutaneous transcatheter repair of heart valves
US8679159B2 (en) 2010-08-30 2014-03-25 Depuy Mitek, Llc Anchor driver with suture clutch
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9861350B2 (en) 2010-09-03 2018-01-09 Ancora Heart, Inc. Devices and methods for anchoring tissue
US10076327B2 (en) 2010-09-14 2018-09-18 Evalve, Inc. Flexible actuator mandrel for tissue apposition systems
EP2438954B1 (en) 2010-10-08 2016-12-28 Greatbatch Ltd. Bi-directional catheter steering handle
US8968335B2 (en) 2010-10-27 2015-03-03 Mitralign, Inc. Hand operated device for controlled deployment of a tissue anchor and method of using the same
US9005279B2 (en) 2010-11-12 2015-04-14 Shlomo Gabbay Beating heart buttress and implantation method to prevent prolapse of a heart valve
US9198756B2 (en) 2010-11-18 2015-12-01 Pavilion Medical Innovations, Llc Tissue restraining devices and methods of use
US9289295B2 (en) 2010-11-18 2016-03-22 Pavilion Medical Innovations, Llc Tissue restraining devices and methods of use
US8540735B2 (en) 2010-12-16 2013-09-24 Apollo Endosurgery, Inc. Endoscopic suture cinch system
US20120158021A1 (en) 2010-12-19 2012-06-21 Mitralign, Inc. Steerable guide catheter having preformed curved shape
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
EP2670354B1 (en) 2011-01-31 2016-04-27 St. Jude Medical, Inc. Adjustable annuloplasty ring sizing indicator
WO2012106346A1 (en) 2011-01-31 2012-08-09 St. Jude Medical, Inc. Adjustable annuloplasty ring sizing indicator
US8932343B2 (en) 2011-02-01 2015-01-13 St. Jude Medical, Cardiology Division, Inc. Blunt ended stent for prosthetic heart valve
US10111663B2 (en) 2011-02-18 2018-10-30 Ancora Heart, Inc. Implant retrieval device
US10709449B2 (en) 2011-02-18 2020-07-14 Ancora Heart, Inc. Systems and methods for variable stiffness tethers
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9445898B2 (en) 2011-03-01 2016-09-20 Medtronic Ventor Technologies Ltd. Mitral valve repair
EP4119095A1 (en) 2011-03-21 2023-01-18 Cephea Valve Technologies, Inc. Disk-based valve apparatus
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
EP2520250B1 (en) 2011-05-04 2014-02-19 Medtentia International Ltd Oy Medical device for a cardiac valve implant
US8747462B2 (en) 2011-05-17 2014-06-10 Boston Scientific Scimed, Inc. Corkscrew annuloplasty device
WO2012158189A1 (en) 2011-05-17 2012-11-22 Boston Scientific Scimed, Inc. Annuloplasty ring with anchors fixed by curing polymer
WO2012158186A1 (en) 2011-05-17 2012-11-22 Boston Scientific Scimed, Inc. Percutaneous mitral annulus mini-plication
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
WO2012175483A1 (en) 2011-06-20 2012-12-27 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
US9918840B2 (en) 2011-06-23 2018-03-20 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9055932B2 (en) 2011-08-26 2015-06-16 Abbott Cardiovascular Systems, Inc. Suture fastener combination device
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
US8764798B2 (en) 2011-10-03 2014-07-01 Smith & Nephew, Inc. Knotless suture anchor
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US20130116776A1 (en) 2011-11-04 2013-05-09 Valtech Cardio, Ltd. External aortic ring and spool mechanism therefor
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
WO2013078497A1 (en) 2011-12-01 2013-06-06 Milijasevic, Zoran Endoluminal prosthesis
CN104203157B (zh) 2011-12-12 2016-02-03 戴维·阿隆 心脏瓣膜修补器械
KR101198775B1 (ko) 2012-01-18 2012-11-12 박광태 수술용 도구, 이를 위한 수술용 메쉬와 수술용 견인수단, 이를 이용한 수술 방법
US8961602B2 (en) 2012-01-27 2015-02-24 St. Jude Medical, Cardiology Division, Inc. Adjustment suture markers for adjustable annuloplasty ring
EP2628451B1 (en) 2012-02-16 2018-01-31 Cook Medical Technologies LLC Suture retention device
WO2013130641A1 (en) 2012-02-29 2013-09-06 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
US9180008B2 (en) 2012-02-29 2015-11-10 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US9138214B2 (en) 2012-03-02 2015-09-22 Abbott Cardiovascular Systems, Inc. Suture securing systems, devices and methods
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9277990B2 (en) 2012-05-04 2016-03-08 St. Jude Medical, Cardiology Division, Inc. Hypotube shaft with articulation mechanism
DE102012010798A1 (de) 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US9504571B2 (en) 2012-06-07 2016-11-29 Edwards Lifesciences Corporation Systems for implanting annuloplasty rings with microanchors
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
EP2897530B1 (en) 2012-09-21 2019-02-06 Boston Scientific Neuromodulation Corporation Tissue fixation delivery apparatus
CA2885354A1 (en) 2012-09-29 2014-04-03 Mitralign, Inc. Plication lock delivery system and method of use thereof
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
JP2014085548A (ja) 2012-10-24 2014-05-12 Hamamatsu Photonics Kk 光走査装置及び光源装置
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
EP4162902A1 (en) 2012-11-21 2023-04-12 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
WO2014087402A1 (en) 2012-12-06 2014-06-12 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9566057B2 (en) 2012-12-12 2017-02-14 Cook Medical Technologies Llc Suture retention mechanism
CN103908729B (zh) 2012-12-28 2016-12-28 米特拉利根公司 能量辅助组织穿刺装置及其使用方法
EP2943132B1 (en) 2013-01-09 2018-03-28 4Tech Inc. Soft tissue anchors
US20150351906A1 (en) 2013-01-24 2015-12-10 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
EP2961351B1 (en) 2013-02-26 2018-11-28 Mitralign, Inc. Devices for percutaneous tricuspid valve repair
US9579090B1 (en) 2013-02-27 2017-02-28 The Administrators Of The Tulane Educational Fund Surgical instrument with multiple instrument interchangeability
EP2967281B1 (en) 2013-03-11 2019-03-06 Boston Scientific Scimed, Inc. Deflection mechanism
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
WO2014152503A1 (en) 2013-03-15 2014-09-25 Mitralign, Inc. Translation catheters, systems, and methods of use thereof
EP2783624A1 (en) 2013-03-28 2014-10-01 Injeq Oy Bioimpedance sensor, mandrine, cannula and method for measuring bioimpedance
EP3003187B1 (en) 2013-05-24 2023-11-08 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
CN106618802B (zh) 2013-06-06 2018-02-06 戴维·阿隆 心脏瓣膜修复和更换
CN105451688A (zh) 2013-06-14 2016-03-30 哈祖有限公司 用于治疗瓣膜反流的方法和装置
CA2902169C (en) 2013-06-25 2022-07-26 Michael Sutherland Percutaneous valve repair by reshaping and resizing right ventricle
US10368852B2 (en) 2013-06-26 2019-08-06 Strait Access Technologies Holdings (Pty) Ltd Orientation device for use in mitral valve repair
US10028832B2 (en) 2013-07-10 2018-07-24 Medtronic, Inc. Helical coil mitral valve annuloplasty systems and methods
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
US9248018B2 (en) 2013-09-27 2016-02-02 Surendra K. Chawla Valve repair device
US20150100116A1 (en) 2013-10-07 2015-04-09 Medizinische Universitat Wien Implant and method for improving coaptation of an atrioventricular valve
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
JP6231221B2 (ja) 2013-10-25 2017-11-15 ケファリオス ソシエテ・パル・アクスィオン・サンプリフィエＫｅｐｈａｌｉｏｓ Ｓ．Ａ．Ｓ． 調節可能な弁輪形成術リングおよびシステム
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US9522000B2 (en) 2013-11-08 2016-12-20 Coloplast A/S System and a method for surgical suture fixation
US10111750B2 (en) 2013-12-16 2018-10-30 Jeko Metodiev Madjarov Method and apparatus for therapy of aortic valve
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9913717B2 (en) 2014-02-14 2018-03-13 Edwards Lifesciences Corporation Percutaneous leaflet augmentation
WO2015193728A2 (en) 2014-06-19 2015-12-23 4Tech Inc. Cardiac tissue cinching
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
EP3206629B1 (en) 2014-10-14 2021-07-14 Valtech Cardio, Ltd. Apparatus for heart valve leaflet restraining
CN106999178B (zh) 2014-12-02 2019-12-24 4科技有限公司 偏心组织锚定器
EP3232941B1 (en) 2014-12-19 2023-11-08 Meacor, Inc. Surgical system
US10188833B2 (en) 2015-01-21 2019-01-29 Medtronic Vascular, Inc. Guide catheter with steering mechanisms
EP4706567A2 (en) 2015-03-05 2026-03-11 Ancora Heart, Inc. Devices of visualizing and determining depth of penetration in cardiac tissue
EP3087952A1 (en) 2015-04-29 2016-11-02 Kephalios S.A.S. An annuloplasty system and a method for monitoring the effectiveness of an annuloplasty treatment
EP3288496B1 (en) 2015-04-30 2024-05-29 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty technologies
EP3539509B1 (en) 2015-06-01 2021-07-07 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
US10806578B2 (en) 2015-10-21 2020-10-20 Coremedic Ag Medical implant and method for heart valve repair
WO2017066889A1 (en) 2015-10-21 2017-04-27 Coremedic Ag Medical apparatus and method for heart valve repair
CN121796784A (zh) 2015-12-30 2026-04-07 管道医疗技术股份有限公司 二尖瓣瓣叶拴系
US11103350B2 (en) 2016-06-01 2021-08-31 On-X Life Technologies, Inc. Pull-through chordae tendineae system
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
CN110072491B (zh) 2016-10-31 2020-06-26 心脏植入物有限公司 用于在安装到心脏瓣膜环上之前揭示收缩绳索或环圈的位置的不透射线的柔性突起
EP4480453A3 (en) 2016-12-21 2025-01-08 TriFlo Cardiovascular Inc. Heart valve support device and methods for making and using the same
US10478303B2 (en) 2017-03-13 2019-11-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10765515B2 (en) 2017-04-06 2020-09-08 University Of Maryland, Baltimore Distal anchor apparatus and methods for mitral valve repair
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
PL422397A1 (pl) 2017-07-29 2019-02-11 Endoscope Spółka Z Ograniczoną Odpowiedzialnością Układ do sterowania końcówką sondy medycznej, zwłaszcza sondy endoskopu oraz uchwyt endoskopu
US10835221B2 (en) * 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11135062B2 (en) * 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
EP3723624B8 (en) 2017-12-14 2023-11-29 Meacor, Inc. Helical anchor driving system
US11376127B2 (en) 2017-12-20 2022-07-05 W. L. Gore & Associates, Inc. Artificial chordae tendineae repair devices and delivery thereof
CN111655200B (zh) 2018-01-24 2023-07-14 爱德华兹生命科学创新(以色列)有限公司 瓣环成形术结构的收缩
WO2019145941A1 (en) 2018-01-26 2019-08-01 Valtech Cardio, Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
JP7075497B2 (ja) 2018-03-23 2022-05-25 コンメッド コーポレーション 縫合糸アンカードライバー
AU2019238344B2 (en) 2018-03-23 2021-06-24 Neochord, Inc. Device for suture attachment for minimally invasive heart valve repair
US11173030B2 (en) 2018-05-09 2021-11-16 Neochord, Inc. Suture length adjustment for minimally invasive heart valve repair
CA3101316A1 (en) 2018-05-24 2019-11-28 Valtech Cardio, Ltd. Implantable annuloplasty structures to fit multiple annulus sizes
US11039830B2 (en) 2018-07-12 2021-06-22 Medos International Sarl Adjustable loop with locking knot
JP7387731B2 (ja) 2018-07-12 2023-11-28 エドワーズ ライフサイエンシーズ イノベーション （イスラエル） リミテッド 弁輪形成システムおよびそのための係止ツール
US11864751B2 (en) 2018-12-05 2024-01-09 Boston Scientific Scimed, Inc. Endoscopic tissue approximation system and methods
AU2020284630A1 (en) 2019-05-29 2021-11-18 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchor handling systems and methods
US20200390551A1 (en) 2019-06-12 2020-12-17 Northwestern University Transcatheter Annuloplasty System And Method
US12502167B2 (en) 2019-07-16 2025-12-23 Edwards Lifesciences Corporation Tissue remodeling systems and methods
WO2021014440A2 (en) 2019-07-23 2021-01-28 Valtech Cardio, Ltd. Contraction of an annuloplasty structure
US12364606B2 (en) 2019-07-23 2025-07-22 Edwards Lifesciences Innovation (Israel) Ltd. Fluoroscopic visualization of heart valve anatomy
US11672661B2 (en) 2019-08-22 2023-06-13 Silara Medtech Inc. Annuloplasty systems and methods
WO2021041639A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Method and device for mitral repair including papillary muscle relocation
CN114258313A (zh) 2019-08-28 2022-03-29 瓦尔泰克卡迪欧有限公司 低剖面可转向导管
JP2022546160A (ja) 2019-08-30 2022-11-04 エドワーズ ライフサイエンシーズ イノベーション （イスラエル） リミテッド アンカーチャネル先端
KR20220066398A (ko) 2019-09-25 2022-05-24 카디악 임플란츠 엘엘씨 심장 판막 고리 감소 시스템
WO2021084407A1 (en) 2019-10-29 2021-05-06 Valtech Cardio, Ltd. Annuloplasty and tissue anchor technologies
WO2021123975A1 (en) 2019-12-20 2021-06-24 Valtech Cardio, Ltd. Implant-adhering techniques
EP4728993A2 (en) 2020-01-10 2026-04-22 Edwards Lifesciences Innovation (Israel) Ltd. Catheter ultrasound devices and methods for assessing targeted tissue
CN113331995A (zh) 2020-02-18 2021-09-03 杭州德晋医疗科技有限公司 具有锁紧功能的锚钉、锚钉组件及缩环系统
EP4096529B1 (en) 2020-03-23 2025-05-07 Edwards Lifesciences Innovation (Israel) Ltd. Self-locking winch
IL301080A (en) 2020-09-25 2023-05-01 Edwards Lifesciences Innovation Israel Ltd anchor cartridges
CN115968273A (zh) 2020-09-25 2023-04-14 波士顿科学国际有限公司 使迁移最小化并且使接合最大化的组织锚固件
CA3197201A1 (en) 2020-10-27 2022-05-05 Edwards Lifesciences Innovation (Israel) Ltd. Devices and methods for area reduction and closure of cardiac openings or cavities
KR20230107837A (ko) 2020-11-13 2023-07-18 에드워즈 라이프사이언시스 이노베이션 (이스라엘) 리미티드 판막 첨판 치료 시스템 및 방법
WO2022153131A1 (en) 2021-01-15 2022-07-21 Edwards Lifesciences Innovation (Israel) Ltd. Intercommissural leaflet support
WO2022157592A1 (en) 2021-01-21 2022-07-28 Edwards Lifesciences Innovation (Israel) Ltd. Fasteners for percutaneous devices
EP4291103A1 (en) 2021-02-09 2023-12-20 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchors and techniques for use therewith
WO2022172108A1 (en) 2021-02-09 2022-08-18 Edwards Lifesciences Innovation (Israel) Ltd. Systems and apparatuses for heart valve repair
EP4308043A4 (en) 2021-02-16 2025-01-22 Conkay Medical Systems, Inc. Devices, systems, and methods for treating conditions of the heart
KR20230160319A (ko) 2021-03-25 2023-11-23 에드워즈 라이프사이언시스 이노베이션 (이스라엘) 리미티드 심장 판막용 조직-수축 이식물
EP4326196B1 (en) 2021-04-22 2025-02-12 Edwards Lifesciences Innovation (Israel) Ltd. Catheter stabilization devices
CN117396157A (zh) 2021-04-29 2024-01-12 爱德华兹生命科学创新(以色列)有限公司 用于治疗心脏的经导管装置和方法
JP2024520452A (ja) 2021-05-25 2024-05-24 エドワーズ ライフサイエンシーズ コーポレイション 対象の心臓弁の弁尖を修復するための経カテーテル装置
JP2024521909A (ja) 2021-06-04 2024-06-04 エドワーズ ライフサイエンシーズ コーポレイション 心臓壁リモデリング装置用の線材切断ツールおよび方法
US20230218291A1 (en) 2021-08-13 2023-07-13 Ventrimend, Inc Edge to edge repair of the mitral valve
WO2023191954A1 (en) 2022-02-04 2023-10-05 Ventrimend, Inc. Annular repair of the tricuspid valve and the mitral valve

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010128503A2 (en) 2009-05-04 2010-11-11 Valtech Cardio, Ltd. Deployment techniques for annuloplasty ring and over-wire rotation tool
WO2012176195A2 (en) 2011-06-23 2012-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
WO2013069019A2 (en) 2011-11-08 2013-05-16 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
WO2014064694A2 (en) 2012-10-23 2014-05-01 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool

Cited By (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11497605B2 (en) 2005-03-17 2022-11-15 Valtech Cardio Ltd. Mitral valve treatment techniques
US12035898B2 (en) 2005-04-22 2024-07-16 Edwards Lifesciences Corporation Catheter-based tissue remodeling devices and methods
US11344414B2 (en) 2006-12-05 2022-05-31 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US11660191B2 (en) 2008-03-10 2023-05-30 Edwards Lifesciences Corporation Method to reduce mitral regurgitation
US12138168B2 (en) 2008-12-22 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US11116634B2 (en) 2008-12-22 2021-09-14 Valtech Cardio Ltd. Annuloplasty implants
US11202709B2 (en) 2009-02-17 2021-12-21 Valtech Cardio Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US12350149B2 (en) 2009-05-04 2025-07-08 Edwards Lifesciences Innovation (Israel) Ltd. Method and apparatus for repairing a heart valve
US11766327B2 (en) 2009-05-04 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Implantation of repair chords in the heart
US12350158B2 (en) 2009-05-04 2025-07-08 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty ring delivery catheters
US11185412B2 (en) 2009-05-04 2021-11-30 Valtech Cardio Ltd. Deployment techniques for annuloplasty implants
US11844665B2 (en) 2009-05-04 2023-12-19 Edwards Lifesciences Innovation (Israel) Ltd. Deployment techniques for annuloplasty structure
US12485010B2 (en) 2009-05-07 2025-12-02 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
US11723774B2 (en) 2009-05-07 2023-08-15 Edwards Lifesciences Innovation (Israel) Ltd. Multiple anchor delivery tool
US12097118B2 (en) 2009-10-29 2024-09-24 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchor for heart implant
US11617652B2 (en) 2009-10-29 2023-04-04 Edwards Lifesciences Innovation (Israel) Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US11602434B2 (en) 2009-12-02 2023-03-14 Edwards Lifesciences Innovation (Israel) Ltd. Systems and methods for tissue adjustment
US12138165B2 (en) 2011-06-23 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty implants
US12409032B2 (en) 2011-06-23 2025-09-09 Edwards Lifesciences Innovation (Israel) Ltd. Percutaneous implantation of an annuloplasty structure
US12274620B2 (en) 2011-11-04 2025-04-15 Edwards Lifesciences Innovation (Israel) Ltd. Implant having multiple adjusting mechanisms
US11197759B2 (en) 2011-11-04 2021-12-14 Valtech Cardio Ltd. Implant having multiple adjusting mechanisms
US11857415B2 (en) 2011-11-08 2024-01-02 Edwards Lifesciences Innovation (Israel) Ltd. Controlled steering functionality for implant-delivery tool
US12508129B2 (en) 2011-12-12 2025-12-30 Edwards Lifesciences Corporation Cardiac valve replacement
US11969348B2 (en) 2011-12-12 2024-04-30 Edwards Lifesciences Corporation Cardiac valve replacement
US11395648B2 (en) 2012-09-29 2022-07-26 Edwards Lifesciences Corporation Plication lock delivery system and method of use thereof
US11890190B2 (en) 2012-10-23 2024-02-06 Edwards Lifesciences Innovation (Israel) Ltd. Location indication system for implant-delivery tool
US11344310B2 (en) 2012-10-23 2022-05-31 Valtech Cardio Ltd. Percutaneous tissue anchor techniques
US12274618B2 (en) 2012-10-23 2025-04-15 Edwards Lifesciences Innovation (Israel) Ltd. Location indication system for implant-delivery tool
US12414772B2 (en) 2012-10-23 2025-09-16 Edwards Lifesciences Innovation (Israel) Ltd. Percutaneous tissue anchor techniques
US12251307B2 (en) 2012-12-06 2025-03-18 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for guide-wire based advancement of a tool
US11583400B2 (en) 2012-12-06 2023-02-21 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for guided advancement of a tool
US11793505B2 (en) 2013-02-26 2023-10-24 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US12419633B2 (en) 2013-02-26 2025-09-23 Edwards Lifesciences Corporation Devices and methods for percutaneous tricuspid valve repair
US12156981B2 (en) 2013-03-14 2024-12-03 Edwards Lifesciences Innovation (Israel) Ltd. Guidewire feeder
US11534583B2 (en) 2013-03-14 2022-12-27 Valtech Cardio Ltd. Guidewire feeder
US11890194B2 (en) 2013-03-15 2024-02-06 Edwards Lifesciences Corporation Translation catheters, systems, and methods of use thereof
US12396720B2 (en) 2013-08-31 2025-08-26 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US11744573B2 (en) 2013-08-31 2023-09-05 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US11766263B2 (en) 2013-10-23 2023-09-26 Edwards Lifesciences Innovation (Israel) Ltd. Anchor magazine
US12408918B2 (en) 2013-10-23 2025-09-09 Edwards Lifesciences Innovation (Israel) Ltd. Anchor magazine
US12138164B2 (en) 2015-04-30 2024-11-12 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty technologies
US11660192B2 (en) 2015-12-30 2023-05-30 Edwards Lifesciences Corporation System and method for reshaping heart
US11890193B2 (en) 2015-12-30 2024-02-06 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US11540835B2 (en) 2016-05-26 2023-01-03 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US12102533B2 (en) 2016-07-08 2024-10-01 Edwards Lifesciences Innovation (Israel) Ltd. Adjustable annuloplasty device with alternating peaks and troughs
US11883611B2 (en) 2017-04-18 2024-01-30 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US11832784B2 (en) 2017-11-02 2023-12-05 Edwards Lifesciences Innovation (Israel) Ltd. Implant-cinching devices and systems
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US12364605B2 (en) 2017-11-20 2025-07-22 Edwards Lifesciences Innovation (Israel) Ltd. Cinching of dilated heart muscle
US11779463B2 (en) 2018-01-24 2023-10-10 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US12551343B2 (en) 2018-01-26 2026-02-17 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for fluoroscopic cardiac measurement
US11666442B2 (en) 2018-01-26 2023-06-06 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
US11890191B2 (en) 2018-07-12 2024-02-06 Edwards Lifesciences Innovation (Israel) Ltd. Fastener and techniques therefor
US11123191B2 (en) 2018-07-12 2021-09-21 Valtech Cardio Ltd. Annuloplasty systems and locking tools therefor
US12226096B2 (en) 2019-05-29 2025-02-18 Edwards Lifesciences Innovation (Israel) Ltd. Tissue anchor handling systems and methods
US12364606B2 (en) 2019-07-23 2025-07-22 Edwards Lifesciences Innovation (Israel) Ltd. Fluoroscopic visualization of heart valve anatomy
US12502277B2 (en) 2019-07-23 2025-12-23 Edwards Lifesciences Innovation (Israel) Ltd. Contraction of an annuloplasty structure
US12440648B2 (en) 2019-08-28 2025-10-14 Edwards Lifesciences Innovation (Israel) Ltd. Low-profile steerable catheter
US12419749B2 (en) 2019-08-30 2025-09-23 Edwards Lifesciences Innovation (Israel) Ltd. Anchor channel tip
US12208006B2 (en) 2019-09-25 2025-01-28 Edwards Lifesciences Corporation Constricting a cardiac valve annulus using a cord that has a loop portion and a single second portion
US11819411B2 (en) 2019-10-29 2023-11-21 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
US12588907B2 (en) 2020-03-23 2026-03-31 Edwards Lifesciences Innovation (Israel) Ltd. Self-locking winch
US12023247B2 (en) 2020-05-20 2024-07-02 Edwards Lifesciences Corporation Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus
US12396718B2 (en) 2020-06-19 2025-08-26 Edwards Lifesciences Corporation Self-stopping tissue anchors

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