US20080091169A1 - Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires - Google Patents
Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires Download PDFInfo
- Publication number
- US20080091169A1 US20080091169A1 US11/953,604 US95360407A US2008091169A1 US 20080091169 A1 US20080091169 A1 US 20080091169A1 US 95360407 A US95360407 A US 95360407A US 2008091169 A1 US2008091169 A1 US 2008091169A1
- Authority
- US
- United States
- Prior art keywords
- flat
- wire
- wires
- assembly
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
- A61M25/0012—Making of catheters or other medical or surgical tubes with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0147—Tip steering devices with movable mechanical means, e.g. pull wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0147—Tip steering devices with movable mechanical means, e.g. pull wires
- A61M2025/015—Details of the distal fixation of the movable mechanical means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/005—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
- A61M25/0053—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid
Definitions
- the present invention pertains generally to catheters that are used in the human body. More particularly, the present invention is directed to steerable catheters using flat pull wires to reduce the overall outer dimension of the catheter and a torque transfer layer made of braided flat wires and configured to provide increased strength, flexibility, and kink resistance.
- catheters are used for an ever-growing number of procedures.
- catheters are used for diagnostic, therapeutic, and ablative procedures, to name just a few examples.
- the catheter is manipulated through the patient's vasculature and to the intended site, for example, a site within the patient's heart.
- the catheter typically carries one or more electrodes, which may be used for ablation, diagnosis, or the like.
- an introducer catheter is a tube having a high degree of directional control that is used to place other catheters, which may have little or no directional control, into specific areas of the patient's body.
- introducer catheters may be used to negotiate the patient's vasculature such that an ablation device may be passed therethrough and positioned to ablate arrhythmia-causing cardiac tissue.
- the introducer catheter itself may be advanced over a guide wire.
- the introducer catheter must have an overall diameter small enough to negotiate blood vessels while retaining an inner diameter (or “bore size”) large enough to accommodate the ablation device therethrough. Furthermore, since the path within the patient is often long and tortuous, steering forces must be transmitted over relatively great distances. Accordingly, it is desirable for the introducer catheter to have sufficient axial strength to be pushed through the patient's vasculature via a force applied at its proximal end (“pushability”). It is also desirable for the introducer catheter to transmit a torque applied at the proximal end to the distal end (“torqueability”). An introducer catheter should also have sufficient flexibility to substantially conform to the patient's vasculature and yet resist kinking as it does so.
- Jaraczewski To improve pushability, torqueability, flexibility, and kink resistance, many extant introducer catheters utilize one or more reinforcing layers in their construction.
- the guiding catheter disclosed in U.S. Pat. No. 4,817,613 to Jaraczewski et al. (“Jaraczewski”) includes a pair of braided torque transmitting layers sandwiched between a flexible tubular member and a flexible plastic casing applied as a viscous material and subsequently cured. Jaraczewski also teaches, however, that to a certain degree, flexibility comes at the expense of torqueability. Further, depending on the thickness of the torque transfer layers, they may increase the wall thickness, thereby either increasing the overall diameter of the introducer catheter for a given bore size or decreasing the bore size for a given overall diameter.
- a catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism.
- the steering mechanism includes at least one flat wire and a corresponding lumen for each of the at least one flat wire through which the flat wire may travel.
- the catheter assembly may include a layer of heat shrink material encompassing the outer layer, a central lumen, and/or a braided wire assembly contained in the outer layer.
- the overall cross-section of the catheter assembly may be substantially circular.
- the outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat.
- the flat wire or wires may be encased in a preformed tube in which the flat wire may travel.
- the flat wire may have a rectangular cross-section, typically having dimensions of about X by about 3 ⁇ , and the cross-section of the preformed tube may be oval, round, or elliptical. That is, the cross-section of the preformed tube may be of a different shape than the cross-section of the flat wire disposed therein.
- the flat wire may be coated with a lubricious substance to permit the flat wire to slide in its lumen, or optionally, the flat wire may be manufactured with a smooth surface to reduce friction between the flat wire and its lumen.
- the braided wire assembly may extend from a base of the catheter assembly to a distal end of the catheter assembly, and a braid density may transition from a first braid density at the base to a lower braid density at the distal end.
- the braid density may be about 50 PPI at the base and about 10 PPI at the distal end.
- the braid density at the distal end may be about 20% to about 35% of the braid density at the base.
- Also disclosed is a method of manufacturing a catheter including the steps of: providing a mandrel; placing a lining material over the mandrel to form an inner liner; providing at least one flat shaped wire; placing a flexible liner over each of the at least one flat shaped wires to create at least one flat lumen; placing a braided wire assembly over the inner liner and the at least one flat lumen; covering the braided wire assembly with a melt processing polymer; applying sufficient heat to the melt processing polymer to raise the temperature of the polymer above its melting point; cooling the assembly; and removing the mandrel, thereby forming a catheter.
- the catheter is manufactured such that it has a cross-section with an outer shape that is substantially circular with an outer diameter of less than about 12F.
- the melt processing polymer may be covered with shrink wrap tubing to help promote the polymer flowing through the braided wire assembly.
- the shrink wrap tubing may be left in place after manufacturing, or it may be removed as part of the manufacturing process.
- the melt processing polymer is typically selected from Nylon, Pebax and other thermal elastomers.
- additional layers of melt processing polymers may be placed over the flat lumen and the inner liner.
- the flat wire and the flexible liner being placed over the flat wire will each have different cross-sectional shapes.
- a method of manufacturing a steerable introducer catheter including the steps of: providing a mandrel; laminating the mandrel with a lining material to form an inner liner; providing at least one flat shaped wire; covering the inner liner and the at least one flat shaped wire with a melt processing polymer; applying sufficient heat to the melt processing polymer to raise the temperature of the polymer above its melting point; cooling the assembly; and removing the mandrel, thereby forming a steerable introducer catheter.
- a flexible tube is placed over each of the at least one flat shaped wires to create at least one corresponding lumen for each of the wires, and further, the melt processing polymer may be covered with a layer of shrink wrap tubing.
- the braided wire assembly may be characterized by a braid density that transitions from a first number at the base to a lower number at the tip. The variation in braid density may range from about 50 PPI at the base to about 10 PPI at the distal end.
- a catheter or an introducer catheter for cardiac surgery comprises a tubular inner liner, a torque transfer layer, or reinforcing layer, surrounding at least a portion of the inner liner, the torque transfer layer comprising at least two flat wires braided into a wire mesh, and an outer sheath formed over to the torque transfer layer.
- the flat wires are substantially rectangular in cross-section and have a width of at least about 0.007 inches and a depth of at least about 0.003 inches.
- the tubular inner liner has a lumen diameter of at least about 6 French.
- the catheter is an introducer catheter.
- the tubular inner liner is polymeric and the outer sheath comprises a melt-processing polymer.
- the ratio of width to thickness of the introducer catheter may be between about 2:1 and about 5:1.
- the torque transfer layer has a braid density of between about 5 PPI and about 100 PPI and may be braided in a one-over, one-under pattern, or a two-over, two-under pattern.
- the outer sheath comprises a plurality of segments having differing hardness characteristics, and the segments are reflow bonded together.
- the catheter assembly of the present invention may also include a pull ring to which the at least two flat wires are secured.
- the pull ring may be a right circular cylinder having a slot for each of the at least two flat wires.
- the pull ring has two slots spaced on opposite sides of the pull ring, and each of the flat wires is secured in the slot by a laser weld.
- the pull ring may further include at least two flow holes such that the outer layer will bond to the pull ring during melt processing as the melt processing polymer flows through the flow holes and then becomes rigid after cooling.
- the catheter assembly of the present invention may also include a shaft made of at least three segments, wherein each segment has a different hardness characteristic.
- a first shaft segment may be made of nylon
- a second segment may be made of a first Pebax
- a third segment may be made of a second Pebax that is more flexible than both the nylon and the first Pebax. Additional segments may be used to form the shaft, each of which may have greater or lesser degrees of stiffness.
- a pull ring assembly for a catheter including a pull ring having at least one rectangular slot and at least one flat pull wire, wherein each of the at least one flat pull wires is secured to the at least one rectangular slot of the pull ring.
- the pull ring assembly will include at least two slots and at least two flat pull wires secured in the slots.
- the pull ring may include flow holes though which a melt processing polymer may flow during lamination.
- a pull ring assembly includes a pull ring having at least two rectangular slots and at least two pull wires, wherein each of the at least two pull wires is secured to the rectangular slot of the pull ring.
- the pull ring may include flow holes though which a melt processing polymer may flow during lamination.
- a technical advantage of the present invention is that overall cross-section of the catheter may be reduced.
- Another technical advantage of the present invention is that a steerable catheter using flat pull wires may be provided that enjoys greater flexibility.
- Yet another technical advantage of the invention is it may utilize an improved braided wire assembly that provides for greater flexibility and control of a catheter.
- a further technical advantage of the invention is that a method of manufacturing an improved steerable catheter is provided.
- Yet another technical advantage of the invention is that a catheter shaft having greater flexibility and control may be utilized.
- a further technical advantage of the invention is that a method of manufacturing an introducer with a lower profile outer diameter with improved steerability is provided.
- FIG. 1 is perspective view of an embodiment of a catheter of the present invention.
- FIG. 2 illustrates a perspective view of a section of a catheter according to an embodiment of the present invention, cut away to show details.
- FIG. 3 is a cross-sectional view taken along line 3 - 3 in FIG. 2 .
- FIG. 4 is a cross-sectional view taken along line 4 - 4 in FIG. 2 .
- FIG. 5 is a cross-sectional view taken along line 5 - 5 in FIG. 2 .
- FIG. 6 is a cross-sectional view of a catheter assembly prior to the application of heat to melt process the outer layer.
- FIG. 7 is a cross-sectional view of a catheter after the application of heat to melt process the outer layer.
- FIG. 8 illustrates a perspective view of a partially assembled catheter in accordance with another embodiment of the invention, cut away to show details.
- FIG. 9 illustrates a pull ring that may be used in a catheter according to the present invention.
- FIG. 10 is a sectional view of the pull ring of FIG. 9 taken along line 10 - 10 .
- FIG. 11 is a cross-sectional view of a steerable, large bore introducer in accordance with another embodiment of the present invention.
- FIG. 12 depicts a reflow mandrel assembly used in the method of manufacturing introducers in accordance with the present invention.
- FIG. 13 depicts an inner layer disposed over a reflow mandrel assembly in accordance with a preferred method of manufacture.
- FIG. 14 depicts a torque transfer layer disposed over an inner layer in accordance with a preferred method of manufacture.
- FIG. 15 depicts an outer sheath of varying components disposed over a torque transfer layer in accordance with a preferred method of manufacture.
- FIG. 16 depicts the components of an introducer assembled over a reflow mandrel assembly having a distal configuration for a tip assembly.
- FIG. 17 depicts a tip component, having a radiopaque marker, attached to the distal end of the introducer depicted in FIG. 16 .
- FIG. 18 depicts another tip component, having a radiopaque marker, attached to the distal end of the introducer depicted in FIG. 16 .
- the present invention provides an improved steerable catheter that minimizes the overall outer dimensions by utilizing a variety of improved techniques.
- One technique is to utilize flat wire as the pull wires for the steerable catheter.
- a “flat wire” or a “flat pull wire” refers to a wire that is characterized by a cross-section that, when measured along two orthogonal axes, is substantially flat.
- a flat wire typically has a rectangular cross-section.
- the rectangular cross-section may be approximately 0.004′′ ⁇ 0.012′′.
- the cross-section need not be perfectly rectangular.
- the present invention contemplates a cross-section of the flat wire may be oval, provided that the overall cross-section is generally flat.
- a wire may be properly characterized as a flat wire if it has a cross-section that is measured X in one direction and at least 3X in a second direction generally orthogonal to the first direction.
- a wire whose cross-section is substantially I-shaped may also be a flat wire if, generally, its height is substantially greater than its width at its widest measurement.
- a flat wire may be defined in the context of the overall teachings of this application.
- a flat wire as a pull wire also has the added benefit that it provides greater resistance to deflection in certain directions.
- the shape of a round wire is not predisposed to resist deflection in any particular direction, whereas the shape of a flat wire will be predisposed to resist deflection on a first axis, and yet predisposed to permit deflection on a second axis that is orthogonal to the first axis.
- a pull wire that is not circular, a catheter can be predisposed to permit and favor deflection in one direction over another.
- the outer diameter of the catheter may also be minimized at the distal tip by an improved braided wire assembly.
- a braid may be used that is characterized by a varying braid density from the proximal end to the distal tip.
- the braid is less dense at the tip than at the proximal end of the catheter.
- FIG. 1 is a perspective view of a catheter assembly 110 according to one embodiment of the present invention comprising a catheter or an introducer catheter 100 having a proximal portion 110 and a distal portion 190 .
- the catheter 100 may be operably connected to a handle assembly 106 which assists in guiding or steering the introducer during procedures.
- the catheter assembly 110 further includes a hub 108 operably connected to an inner lumen (not shown) within the handle assembly 106 for insertion or delivery of catheter assemblies, fluids, or any other devices known to those of ordinary skill in the art.
- the catheter assembly 110 further includes a valve 112 operably connected to the hub 108 .
- FIG. 2 illustrates a perspective view of a catheter according to a preferred embodiment of the present invention, cut away to show details.
- catheter assembly The basic method of manufacture of catheter 100 according to an embodiment of the present invention will be described with reference to FIGS. 2, 3 , 4 , 6 , 7 and 8 . As they are assembled, the catheter components will be collectively referred to as a catheter assembly.
- a mandrel 10 which is preferably round in cross-section and preferably from about 6 inches to about 4 feet in length, is a component of the catheter assembly 200 , and may be the first component thereof during manufacture of catheter 100 .
- Mandrel 10 has a distal end and a proximal end.
- An inner liner 20 is placed on mandrel 10 .
- Inner liner 20 may be knotted at one end (e.g. the distal end) and then fed onto mandrel 10 .
- inner liner 20 is an extruded polytetrafluoroethylene (PTFE) tubing, such as Teflon® brand tubing, which is available commercially.
- Inner liner 20 may also be made of other melt processing polymers, including, without limitation, etched polytetrafluoroethylene, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax®, made by Arkema, Inc. Pebax of various durometers may be used, including, without limitation, Pebax 30D to Pebax 70D.
- inner liner 20 is made of a material with a melting temperature higher than that of an outer layer 60 , which will be further described below, such that inner liner 20 will withstand melt processing of outer layer 60 .
- a flat wire 30 is placed longitudinally along inner liner 20 .
- Flat wire 30 is preferably composed of stainless steel and is preferably about 0.002′′ by about 0.016′′, and more preferably about 0.004′′ by about 0.012′′.
- at least a portion of flat wire 30 is encased inside another preformed tube 40 before placement along inner liner 20 to form a flat lumen 42 .
- Preformed tube 40 need not have the same shape as the cross-section of flat wire 30 , but instead may be round, oval, rectangular, or another like shape.
- preformed tube 40 has a cross-section that is not the same shape as the cross-section of flat wire 30 in order to facilitate movement of flat wire 30 in preformed tube 40 .
- Preformed tube 40 may be formed of polytetrafluoroethylene, polyether block amides, nylon, other thermoplastic elastomers, or another substance.
- preformed tube 40 has a higher melting point than outer layer 60 , which will be further described below, so that preformed tube 40 will not melt when outer layer 60 is subjected to melt processing.
- flat wire 30 may be covered with lubricious materials including silicone, Teflon®, siloxane, and other lubricious materials (not shown), before placement.
- flat wire 30 may also be coated with a lubricious layer to promote slideability. It is also contemplated that flat wire 30 may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material from which to compose flat wire 30 , other materials may be used, including, without limitation, materials that are used for conventional round pull wires.
- each such flat wire 30 may be encased inside its own flexible tube 40 to form separate flat lumens 42 .
- a pair of flat wires 30 are used, spaced apart about 180 degrees about the circumference of inner liner 20 .
- Outer layer 60 is then placed over inner liner 20 , flat wires 30 , and preformed tube 40 forming flat lumen 42 .
- Outer layer 60 may be made of either single or multiple sections of tubing that may be either butted together or overlapped with each other.
- outer layer 60 is an extruded polytetrafluoroethylene tubing, such as Teflon® brand tubing, which is available commercially.
- Outer layer 60 may also be made of other melt processing polymers, including, without limitation, etched polytetrafluoroethylene, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax® made by Arkema, Inc. Pebax of various durometers may be used, including, without limitation, Pebax 30D to Pebax 70D.
- Outer layer 60 may also comprise more than one layer, including for example two or more tubes of a melt processing polymer.
- a braided wire assembly 50 may be placed over inner liner 20 and any flat wires 30 before outer layer 60 is applied.
- Braided wire assembly 50 may be formed of stainless steel wire, including for example 0.003′′ high tensile stainless steel wire.
- Braided wire assembly 50 may be formed in a standard braid pattern and density, for example, about 16 wires at about 45 to about 60 picks per inch (“PPI”) density.
- PPI picks per inch
- a braid may be used that is characterized by a varying braid density.
- braided wire assembly 50 may be characterized by a first braid density at proximal end 110 of catheter 100 and then transition to one or more different braid densities as braided wire assembly 50 approaches distal end 190 of catheter 100 .
- the braid density of distal end 190 may be greater or less than the braid density at proximal end 110 .
- the braid density at the base i.e., proximal end 110
- the braid density at distal end 190 is about 10 PPI.
- the braid density at distal end 190 is about 20% to about 35% of the braid density at the base/proximal end 110 .
- Braided wire assembly 50 may be formed separately on a disposable core. One or more portions of braided wire assembly 50 may be heat tempered and cooled before incorporation into catheter assembly 200 though methods that are known to those of ordinary skill. The action of heat tempering may help to release the stress on the wire and help reduce radial forces.
- FIG. 6 displays a cross-section of catheter assembly 200 having two flat wires 30 and braided wired assembly 50 encompassed by outer layer 60 before lamination of the materials by heating.
- a layer of heat shrink 70 is placed over the top of outer layer 60 as depicted in FIG. 6 .
- Heat shrink 70 is preferably a fluoropolymer or polyolefin material.
- FIG. 7 depicts catheter assembly 200 after a lamination process.
- Catheter assembly 200 may be laminated by heating catheter assembly 200 until the material comprising outer layer 60 flows and redistributes around the circumference thereof as depicted in FIG. 7 .
- Heat shrink 70 has a higher melting temperature than outer layer 60 ; and during the melt process, heat shrink 70 retains its tubular shape and forces the liquefied outer layer 60 material into braided wire assembly 50 (if present) and into contact with flat wires 30 and inner liner 20 .
- Catheter assembly 200 may then be cooled. In FIG. 7 , mandrel 10 is still in place.
- Mandrel 10 may be removed from catheter assembly 200 , leaving behind a lumen 80 as illustrated in FIG. 4 , which depicts a catheter 100 made in accordance with the method of the present invention subsequent to the application of heat for the lamination process.
- heat shrink 70 may be left in place around outer layer 60 , as depicted in FIG. 7 , even after mandrel 10 is removed.
- FIG. 3 is a cross-sectional view taken at the point of a pull ring 90 as depicted in FIG. 2
- FIG. 4 is a cross-sectional view taken at a point proximal to pull ring 90
- FIG. 8 is a perspective view of catheter assembly 200 , cut away to show certain details of construction.
- Catheter assembly 200 may be manufactured using alternative techniques.
- outer layer 60 may be formed by extruding outer layer 60 over catheter assembly 200 .
- catheter assembly 200 may formed by using a combination of heat and a press that has a mold for defining the final shape of catheter 100 .
- Catheter 100 formed using the methods of this invention may have varying sizes and various uses.
- catheter 100 may be used in atrial fibrillation cases as well as atrial tachycardia cases.
- catheter 100 manufactured using the improvements discussed herein is preferably less than about 12F outer diameter, and more preferably less than about 10F outer diameter.
- a catheter size of less than about 11F outer diameter may be preferred.
- larger catheter sizes are feasible, particularly when the torque transfer layer is made of braided flat wires.
- catheter 100 construction may be modified to utilize materials of various durometer hardness (as measured, for example, using a Shore durometer hardness scale).
- proximal end 110 of catheter 100 may be made of a material such as nylon 11, and the remainder of catheter 100 may be made of one or more Pebax materials.
- the durometer hardness levels will decrease as catheter 100 shaft approaches distal end 190 .
- a nylon base may then be followed by one or more of the following Pebax segments: 70D Pebax; 60D Pebax; 55D Pebax; 40D Pebax; 35D Pebax; 30D Pebax.
- Catheter 100 may also use one or more blends of the foregoing Pebax materials, including for example, a 70D/60D Pebax blend made by co-extrusion, or a 40D/35D Pebax blend made by co-extrusion.
- catheter 100 made with one or more segments of varying durometers will be reflowed together during manufacturing.
- the length of the segments may vary.
- Proximal end 110 of catheter 100 is preferably the longest segment, and more distal segments may preferably vary between about 0.25′′ to about 6′′, and more preferably from about 0.25′′ to about 3′′.
- the hardness levels of the segments and the lengths of the segments may be adjusted for specific applications, and preferably, the distal tip segment may have the lowest durometer of all segments.
- the segments may be selected to optimize stability and torque delivery for the specific application.
- FIG. 5 illustrates another embodiment of the invention in which outer layer 60 is composed of multiple segments 61 , 62 , 63 , 64 , each of which has different material properties, such as degree of hardness, stiffness, or tensile strength.
- segment 61 has the greatest degree of hardness; segments 62 , 63 , and 64 are more flexible than segment 61 ; segments 63 and 64 are more flexible than segments 61 and 62 ; and finally, segment 64 is more flexible than each of segments 61 , 62 and 63 .
- the number of segments may vary, as well as the relative lengths of the segments.
- a modified braided wire assembly 50 is inserted between inner liner 20 and outer layer 60 .
- Braided wire assembly 50 may be designed to have transitional braid densities starting at one braid density and transitioning to a lower braid density.
- the braid may begin at a braid density of about 50 to about 60 PPI, and more preferably between about 50 and about 55 PPI, and then transition to a braid density at the tip of about 5 to about 20 PPI, and more preferably between about 5 to about 15 PPI.
- the braid density may transition slowly, or it may change using one or more segments. For example, there may be an intermediate zone with a braid density of about 30 to about 45 PPI. Variations in the braid density of braided wire assembly 50 may be used to increase or decrease flexibility of catheter 100 depending on the desired application.
- pull ring 90 is utilized to provide steerability.
- FIGS. 9 and 10 illustrate a preferred embodiment for pull ring 90 .
- Pull ring 90 is a generally circular band with a cross-sectional shape (measured orthogonally to a tangential line relative to the circle of the band) that is substantially rectangular. The rectangular cross-section is more clearly depicted in FIG. 10 .
- the outer dimension of pull ring 90 is preferably determined based on the application for catheter 100 to be manufactured. In one embodiment, pull ring 90 is about 0.10′′ in diameter.
- Pull ring 90 preferably has at least one slot 91 that is configured to accommodate flat pull wire 30 .
- Flat pull wire 30 may secured within slot 91 by any technique that is appropriate given the materials of pull ring 90 and flat pull wires 30 .
- Acceptable techniques may include, but are not limited to, laser welding and/or other welding and bonding techniques.
- pull ring 90 may contain one or more flow holes 95 as illustrated in FIGS. 9 and 10 .
- flow holes 95 are depicted as circular, other shapes may be used.
- pull ring 90 includes two 0.025′′ flow holes 95 spaced about 180 degrees apart around the circumference of pull ring 90 . The size and shape of flow holes 95 may be adjusted based on the materials being used to form inner liner 20 and/or outer layer 60 .
- pull ring 90 is utilized with non-flat pull wires.
- Pull ring 90 of this embodiment is preferably a circular band with a cross-sectional shape (measured orthogonally to a tangential line relative to the circle of the band) that is substantially rectangular.
- pull ring 90 has at least one slot that is configured to accommodate a non-flat pull wire (such as a round wire).
- the tip of the non-flat pull wire is tapered to facilitate joinder with pull ring 90 .
- the non-flat pull wire may be secured within the slot by any technique that is appropriate given the materials of pull ring 90 and the pull wires. Acceptable techniques may include, but are not limited to, laser welding and/or other welding and bonding techniques.
- the non-flat pull wire is located within a preformed tube.
- the preformed tube need not be the same shape as the cross-section of the pull wire, but instead, may be round, oval, rectangular, or another like shape.
- the preformed tube has a cross-section that is not the same shape as the cross-section of the pull wire in order to facilitate movement of the pull wire in the preformed tube.
- the preformed tube may be formed of polytetrafluoroethylene, polyether block amides, nylon, other thermoplastic elastomers or another substance.
- the preformed tube has a higher melting point than outer layer 60 so that the preformed tube will not melt when outer layer 60 is subjected to melt processing.
- the pull wire may be covered with lubricious materials, such as silicone and other lubricious materials, before placement.
- the pull wire may be coated with a lubricious layer to promote slideability, and it is also contemplated that the pull wire may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material to compose the pull wire, other materials may be used, including, without limitation, materials that are used for conventional pull wires.
- Pull ring 90 is typically utilized near distal end 190 of catheter 100 , but it is anticipated that pull ring 90 may be located at any position along catheter 100 . Moreover, more than one pull ring 90 may be utilized in the same catheter 100 . In one embodiment of catheter 100 , two separate pull rings 90 may be utilized, each of which has its own flat pull wires 30 connected thereto.
- pull ring 90 may be made of stainless steel or other materials, including, without limitation, materials that are used to form conventional pull ring assemblies.
- braided wire assembly 50 may be made of stainless steel or other materials, including materials that are used to form conventional braided wire assemblies.
- the present invention further provides a torque transfer layer using braided flat wires for a catheter and a large bore introducer catheter.
- a flat wire guided, or steerable, introducer catheter For purposes of description, embodiments of the present invention will be described in connection with a flat wire guided, or steerable, introducer catheter. It is contemplated, however, that the described features may be incorporated into any number of catheters or introducer catheters as would be appreciated by one of ordinary skill in the art.
- the large bore introducer catheter is comprised of a combination of components and manufactured by either a reflow process or an extrusion process, which provide the surprising benefits of allowing for introducer catheters having an internal diameter of at least about 6 French while maintaining the desirable improved properties of pushability, torqueability, and flexibility, for outer diameters of sufficient size for navigation of cardiac vasculature.
- FIG. 11 depicts a cross-sectional view of an introducer catheter 1200 in accordance with one embodiment of the present invention.
- the introducer catheter 1200 is comprised of a tubular polymeric inner liner 1202 , a torque transfer layer 1204 , an outer sheath 1206 comprised of a melt-processing polymer, and a heat shrink layer 1208 .
- the introducer catheter 1200 further includes at least one flat wire 1210 disposed longitudinally along the length of the introducer catheter 1200 .
- a “flat wire” refers to a wire that is characterized by a cross-section that, when measured along two orthogonal axes, is substantially flat.
- a flat wire typically has a rectangular cross section, though the cross section need not be perfectly rectangular.
- the present invention contemplates that a cross section of the flat wire may be oval, provided that the overall cross section is generally flat.
- a wire may be properly characterized as a flat wire if it has a cross section that is measured x in one direction and at least 2x in a second direction generally orthogonal to the first direction.
- a wire whose cross section is substantially I-shaped may also be a flat wire if, generally, its height is substantially greater than its width at its widest measurement.
- a flat wire may be defined in the context of the overall teachings of this application.
- the at least one flat wire 1210 may be further encased inside another polymeric tubular member 1212 forming a lumen 1214 for housing the flat wire 1210 .
- the introducer catheter according to this embodiment is manufactured by a reflow bonding process in which the components are individually fed over a mandrel as discussed in more detail below.
- the inner liner 1202 is preferably a polymeric material, such as polytetrafluoroethylene (PTFE) or etched PTFE.
- the inner liner 1202 may also be made of other melt processing polymers, including, without limitation, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax® made by Arkema, Inc. Pebax of various durometers may also be used, including without limitation, Pebax 30D to Pebax 70D.
- the inner liner 1202 is made of a material with a melting temperature higher than the outer sheath 1206 such that the inner liner 1202 will withstand the melt processing of the outer sheath 1206 .
- Inner liner 1202 defines a lumen 1216 therethrough, preferably having a diameter 1218 of at least about 6 French, more preferably of at least about 7 French, and most preferably of between about 10 French and about 24 French. However, in some embodiments of the invention, it is contemplated that lumen 1216 may have a diameter 1218 of up to about 32 French or more, such as between about 7 French and about 32 French.
- a torque transfer layer 1204 is preferably disposed between the inner liner 1202 and the heat shrink layer 1208 , more preferably between the outer sheath 1206 and the inner liner 1202 .
- the torque transfer layer 1204 may be disposed either between the inner layer 1202 and the outer sheath 1206 or between the outer sheath 1206 and the heat shrink layer 1208 .
- the torque transfer layer 1204 may be made of stainless steel (304 or 316) wire or other acceptable materials kown to those of ordinary skill in the art.
- the torque transfer layer 1204 is preferably formed of a braided wire assembly comprised of flat wires, preferably stainless steel wires including, for example, high tensile stainless steel wires.
- the torque transfer layer 1204 may be formed in any number of known braid patterns, including one-over-one (involving at least two wires) or two-over-two (involving at least four wires) crossover patterns.
- the braided flat wires typically have a thickness of at least about 0.0005′′ and a width of at least about 0.005′′. Examples of larger sizes include 0.001′′ ⁇ 0.005′′ and 0.002′′ ⁇ 0.006′′.
- braided flat wires of at least about 0.003′′ thick by at least about 0.007′′ wide which heretofore were not used to form a wire mesh for the torque transfer layer, have produced surprisingly good results of increased pushability, torqueability, flexibility, and kink resistance over non-flat wires and smaller flat wires.
- the individual wires have a ratio of width to the thickness of at least about 2:1, including, for example, 2:1 to 5:1.
- Flat wires of about 0.004′′ thick by about 0.012′′ wide and of about 0.004′′ thick by about 0.020′′ wide have also been braided with success to form torque transfer layers of superior performance.
- the braid density commonly measured in pixels per inch (“PPI”), is typically between about 5 and 100, and will depend on the size of the flat wires as well as the size of the catheter.
- PPI pixels per inch
- the PPI is preferably between about 10 and about 90, more preferably between about 10 and about 55.
- the PPI for flat wires of about 0.003′′ thick by about 0.007′′ wide is preferably between about 20 and about 90, more preferably between about 35 and about 55 for an inner lumen of at least 6 French, and most preferably between about 35 and about 45 for an inner lumen of at least about 10 French.
- the PPI for flat wires of about 0.004′′ thick by about 0.012′′ wide is preferably between about 15 and about 70, and more preferably between about 15 and about 22 for an inner lumen of at least about 6 French.
- the PPI for flat wires of about 0.004′′ thick by about 0.020′′ wide is preferably between about 5 and about 50, and more preferably between about 10 and about 20 for an inner lumen of at least about 6 French, and most preferably between about 10 and about 20 for an inner lumen of at least about 16 French.
- the torque transfer layer 1204 may utilize a varying braid density construction along the length of the introducer catheter 1200 .
- the torque transfer layer may be characterized by a first braid density at the proximal end of the introducer catheter 1200 and then transition to one or more braid densities as the torque transfer layer 1204 approaches the distal end of the introducer catheter 1200 ; the braid density of the distal end may be greater or less than the braid density at the proximal end.
- the braid density at the proximal end is about 50 PPI and the braid density at the distal end is about 10 PPI.
- the braid density at the distal end is about 20-35% of the braid density at the proximal end.
- the torque transfer layer 1204 may be formed separately on a disposable core and subsequently slipped around the inner liner 1202 .
- One or more portions of the torque transfer layer 1204 may be heat tempered and cooled before incorporation into the introducer body 1200 through methods that are known to those of ordinary skill. The action of heat tempering may help to release the stress on the wire and help reduce radial forces. It is also contemplated that torque transfer layer 1204 may be braided directly on the inner liner 1202 .
- a particularly preferred torque transfer layer 1204 is comprised of 0.003′′ by 0.007′′ 304 stainless steel wires at 35 PPI for an inner lumen of 6-10 French.
- Another preferred torque transfer layer 1204 is comprised of 0.004′′ by 0.012′′ 304 stainless steel wires at 22 PPI for an inner lumen of 12 French.
- Yet another preferred torque transfer layer 1204 is comprised of 0.004′′ by 0.020′′ 304 stainless steel wires at 13 PPI for an inner lumen of 16 French.
- These particularly preferred torque transfer layers may manufactured on a commercially available horizontal braid machine set at 225 rpm utilizing a commercially available mandrel. Other suitable methods of manufacturing the torque transfer layer 1204 will be apparent to those of ordinary skill in the art.
- the outer sheath 1206 is preferably either an extruded Pebax or PTFE tubing.
- the melt-processing polymer of the outer sheath 1206 occupies a plurality of voids of the wire mesh in the torque transfer layer.
- the outer sheath 1206 may also be made of other melt processing polymers, including, without limitation, etched PTFE, polyether block amides, nylon and other thermoplastic elastomers, at varying durometers.
- the outer sheath 1206 may also comprise more than one layer, including, for example, two or more tubes of a melt processing polymer. Alternatively, as shown in FIG.
- the outer sheath 306 may be comprised of varying segments 322 , 324 , 326 , 328 , 330 differing in hardness and/or material along the length of the introducer 300 and being reflow bonded together. This may be accomplished by layering or by placing annular rings of differing materials along the length of the introducer 300 . Varying the sheath composition in this manner provides the additional benefit of adjusting flexibility, torqueability, and pushability at various points along the introducer 300 .
- At least one flat wire 1210 is provided, preferably extending along substantially the entire length of the introducer.
- the flat wire 1210 is preferably composed of stainless steel and is preferably about 0.002′′ ⁇ about 0.016′′, and more preferably about 0.004′′ ⁇ about 0.012′′ or 0.016′′.
- the flat wire may be selected such that the ratio of the width to thickness is at least about 2:1.
- at least a portion of the flat wire is encased inside a preformed tube 1212 before placement along the inner liner 1202 to form a flat lumen 1214 .
- the preformed tube 1212 need not be the same shape as the cross section of the flat wire, but instead, may be round, oval, rectangular, or another like shape.
- the preformed tube 1212 has a cross section that is not the same shape as a cross section of the flat wire 1210 , in order to facilitate movement of the flat wire in the preformed tube.
- the preformed tube may be formed of PTFE, etched PTFE, polyether block amides (such as Pebax), nylon, other thermoplastic elastomers, or any other known material to one of ordinary skill in the art.
- the preformed tube 1212 has a higher melting point than the outer sheath 1206 so that the preformed tube 1212 will not melt when the introducer catheter 1200 is subjected to melt processing.
- the flat wire 1210 may be covered with lubricious materials (not shown) before placement, including silicone and other lubricious materials.
- the flat wire 1210 may also be coated with a lubricious layer to promote slideability, and it is also contemplated that the flat wire 1210 may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material to compose the flat wire 1210 , other materials may be used, including, without limitation, materials that are used for conventional round pull wires.
- More than one flat wire 1210 may also be used, and in such cases, each such flat wire 1210 may be encased inside its own flexible tube 1212 .
- a pair of flat wires 1210 are used that are spaced at 180 degrees apart.
- the flat wires 1210 are preferably connected to at least one steering ring typically located near the distal end of the introducer (see, e.g., similar flat wires 30 connected to steering ring 90 in FIG. 2 ).
- the proximal ends of the flat wires 1210 are then operably connected to a steering mechanism (not shown) allowing for manipulation, or steering, of the introducer catheter 1200 during use.
- a mandrel 300 which is preferably round in cross-section and preferably from about 6 inches to about 4 feet in length, is provided.
- the mandrel 300 has a distal end 350 and a proximal end 352 .
- an inner liner 302 is placed on the mandrel 300 .
- the inner liner 302 is fed on to the mandrel 300 and is then knotted on one end 320 , or both ends.
- a torque transfer layer 304 is then placed over the inner liner 302 .
- the flat wire assembly (not shown) may then be placed over the torque transfer layer 304 .
- the flat wire assembly may be placed over an outer sheath 306 .
- Another sheath layer (not shown) may additionally be placed over the flat wire assembly.
- the torque transfer layer terminates proximally of the distal end of the catheter.
- an outer sheath 306 is placed over the torque transfer layer 304 and may be made of either single or multiple sections of tubing that are either butted together or overlapped with each other.
- the multiple segments, or layers, of sheath material may be any length and/or hardness (durometer) allowing for flexibility of design.
- FIG. 15 identifies a plurality of segments, 322 , 324 , 326 , 328 and 330 .
- the proximal end 330 of the outer sheath 306 may be made of a material such as nylon, and the remainder of the introducer may be made of one or more Pebax materials.
- the lengths of the various segments may vary, but preferably, the durometer hardness levels will decrease as the outer sheath 306 approaches its distal end.
- a nylon base may then be followed by one or more of the following Pebax segments: 70D Pebax; 60D Pebax; 55D Pebax; 40D Pebax; 35D Pebax; 30D Pebax.
- the introducer shaft may also use one or more blends of the foregoing Pebax materials, including, for example, 70D/60D Pebax blend made by co-extrusion, or a 40D/35D Pebax blend made by co-extrusion.
- the various components of the outer sheath 306 according to this embodiment will be reflowed together during manufacturing.
- the proximal end of the shaft is preferably the longest segment, and more distal segments may preferably vary between 0.25′′ to 6′′, and more preferably from 0.25′′ to about 3′′.
- the hardness levels of the segments and the lengths of the segments may be adjusted for specific applications, and preferably, the distal end may have the lowest durometer levels of all segments.
- the shaft segments may be selected to improve flexibility, torqueability, and pushability for the specific application, as appreciated by one of ordinary skill in the art.
- the catheter may be formed by placing a thin inner jacket or layer (e.g., PTFE layer) onto a mandrel (e.g., stainless steel mandrel) or extruding a thin inner jacket or layer (e.g., Pebax layer) onto an extrusion mandrel (e.g., acetal mandrel), forming a torque transfer layer over the inner layer, and extruding an outer jacket or sheath (e.g., Pebax jacket) over the torque transfer layer.
- a thin inner jacket or layer e.g., PTFE layer
- a mandrel e.g., stainless steel mandrel
- extrusion mandrel e.g., acetal mandrel
- an outer jacket or sheath e.g., Pebax jacket
- the heat shrink layer 308 is preferably a fluoropolymer or polyolefin material, such as FEP, or other suitable material as appreciated by one of ordinary skill in the art.
- FIG. 11 depicts a cross sectional view of the introducer assembly after this reflow process.
- Introducer assembly 1200 may be laminated by heating the assembly until the material comprising the outer sheath 1206 flows and redistributes around the circumference.
- the heat shrink layer 1208 has a higher melt temperature than the outer sheath 1206 , and during the melt process, the heat shrink layer 1208 retains its tubular shape and forces the liquefied sheath layer material 1206 into the torque transfer layer 1204 and into contact with the flat wires 1210 /preformed tubes 1212 (if present) and the inner liner 1202 .
- the introducer assembly 1200 may then be cooled.
- the mandrel is preferably left in place during the cooling process as it helps the introducer assembly to retain its inner lumen of at least about 6 French.
- the heat shrink layer 1208 may be left on the introducer assembly 1200 , or optionally removed. If the heat shrink layer 1208 is removed, the outer sheath 1206 becomes the outside layer of the introducer catheter 1200 .
- FIGS. 16-18 contemplate the inclusion of a tip assembly for use in medical procedures, such as an atraumatic tip, including, for example, a radiopaque material contained therein for location of the tip during use.
- FIGS. 16-18 depict a cross section of an introducer catheter 700 having a distal portion 730 configured to accept a tip assembly 732 or 734 .
- the tip 732 or 734 includes a ring 736 , e.g., a radiopaque marker, for location of the tip 732 or 734 during use.
- FIG. 18 further includes a tip assembly 734 configured with a plurality of port holes 738 for delivery of, for example, irrigation fluid.
- the tip assembly may further be configured with ablation electrodes (not shown) operably connected to a power supply (not shown), for use in cardiac ablation procedures.
- joinder references do not necessarily infer that two elements are directly connected and in fixed relation to each other. It is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative only and not limiting. Changes in detail or structure may be made without departing from the spirit of the invention as defined in the appended claims.
Abstract
A catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen through which the flat wire may travel. The steering mechanism may also include at least one pull ring to which the flat wires are attached. A layer of heat shrink material may encompass the outer layer. A braided wire assembly may also be provided in the outer layer, and may be formed by braiding a plurality of flat wires into a wire mesh. The overall cross-section of the catheter assembly is preferably substantially circular. A catheter shaft may include a plurality of segments of differing hardness characteristics. The outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat.
Description
- This application is a continuation-in-part of U.S. patent application Ser. No. 11/647,313, filed 29 Dec. 2006, which claims the benefit of U.S. Provisional Patent Application No. 60/800,373, filed 16 May 2006. The entire disclosures of these applications are hereby expressly incorporated by reference as though fully set forth herein.
- a. Field of the Invention
- The present invention pertains generally to catheters that are used in the human body. More particularly, the present invention is directed to steerable catheters using flat pull wires to reduce the overall outer dimension of the catheter and a torque transfer layer made of braided flat wires and configured to provide increased strength, flexibility, and kink resistance.
- b. Background Art
- Catheters are used for an ever-growing number of procedures. For example, catheters are used for diagnostic, therapeutic, and ablative procedures, to name just a few examples. Typically, the catheter is manipulated through the patient's vasculature and to the intended site, for example, a site within the patient's heart. The catheter typically carries one or more electrodes, which may be used for ablation, diagnosis, or the like.
- Many prior catheters use round wires as pull wires, and they typically either embed the wire directly into the catheter wall so that the pull wire and the lumen through which it runs are substantially the same size, or use a round wire to create a pull wire lumen and then place a smaller wire in the lumen as a pull wire. These conventional techniques and methods result in a catheter that is elliptical in its outer shape. An example of an elliptical catheter is disclosed and taught in U.S. Pat. No. 6,582,536, the contents of which are incorporated herein by reference.
- As catheters are used in smaller and smaller passages, there is a growing need to use catheters that have a smaller outer dimension. Accordingly, there is a need to use steerable catheters that have smaller cross-sections.
- It is known that, to facilitate placement of the diagnostic or therapeutic catheter at a location of interest within the patient, it may be introduced through another catheter, commonly known as a “guiding catheter” or “introducer catheter,” and the terms will be used interchangeably herein. Generally speaking, an introducer catheter is a tube having a high degree of directional control that is used to place other catheters, which may have little or no directional control, into specific areas of the patient's body.
- In the field of cardiac ablation, for example, introducer catheters may be used to negotiate the patient's vasculature such that an ablation device may be passed therethrough and positioned to ablate arrhythmia-causing cardiac tissue. The introducer catheter itself may be advanced over a guide wire.
- Generally, it is known that the introducer catheter must have an overall diameter small enough to negotiate blood vessels while retaining an inner diameter (or “bore size”) large enough to accommodate the ablation device therethrough. Furthermore, since the path within the patient is often long and tortuous, steering forces must be transmitted over relatively great distances. Accordingly, it is desirable for the introducer catheter to have sufficient axial strength to be pushed through the patient's vasculature via a force applied at its proximal end (“pushability”). It is also desirable for the introducer catheter to transmit a torque applied at the proximal end to the distal end (“torqueability”). An introducer catheter should also have sufficient flexibility to substantially conform to the patient's vasculature and yet resist kinking as it does so. One of ordinary skill in the art will recognize that these various characteristics are often in tension with one another, with improvements in one requiring compromises in others. For example, increasing the bore size of an introducer catheter having a given overall diameter requires utilizing a thinner wall. A thin-walled introducer, however, is more likely to collapse upon itself when a torque is applied at its proximal end.
- To improve pushability, torqueability, flexibility, and kink resistance, many extant introducer catheters utilize one or more reinforcing layers in their construction. For example, the guiding catheter disclosed in U.S. Pat. No. 4,817,613 to Jaraczewski et al. (“Jaraczewski”) includes a pair of braided torque transmitting layers sandwiched between a flexible tubular member and a flexible plastic casing applied as a viscous material and subsequently cured. Jaraczewski also teaches, however, that to a certain degree, flexibility comes at the expense of torqueability. Further, depending on the thickness of the torque transfer layers, they may increase the wall thickness, thereby either increasing the overall diameter of the introducer catheter for a given bore size or decreasing the bore size for a given overall diameter.
- Many extant large bore introducers (i.e., an introducer catheter with bore size of greater than about 6 French), in order to find a suitable balance of pushability, torqueability, flexibility, and kink resistance, have outer layers that are relatively stiff, which compromises torqueability, kink resistance, and flexibility for pushability.
- According to a first embodiment of the invention, a catheter assembly includes an inner liner made of flexible material and an outer layer having a steering mechanism. The steering mechanism includes at least one flat wire and a corresponding lumen for each of the at least one flat wire through which the flat wire may travel. Optionally, the catheter assembly may include a layer of heat shrink material encompassing the outer layer, a central lumen, and/or a braided wire assembly contained in the outer layer. The overall cross-section of the catheter assembly may be substantially circular. The outer layer typically comprises a melt processing polymer such that the catheter assembly may be laminated using heat.
- Optionally, the flat wire or wires may be encased in a preformed tube in which the flat wire may travel. The flat wire may have a rectangular cross-section, typically having dimensions of about X by about 3×, and the cross-section of the preformed tube may be oval, round, or elliptical. That is, the cross-section of the preformed tube may be of a different shape than the cross-section of the flat wire disposed therein. The flat wire may be coated with a lubricious substance to permit the flat wire to slide in its lumen, or optionally, the flat wire may be manufactured with a smooth surface to reduce friction between the flat wire and its lumen.
- The braided wire assembly may extend from a base of the catheter assembly to a distal end of the catheter assembly, and a braid density may transition from a first braid density at the base to a lower braid density at the distal end. For example, the braid density may be about 50 PPI at the base and about 10 PPI at the distal end. Alternatively, the braid density at the distal end may be about 20% to about 35% of the braid density at the base.
- Also disclosed is a method of manufacturing a catheter including the steps of: providing a mandrel; placing a lining material over the mandrel to form an inner liner; providing at least one flat shaped wire; placing a flexible liner over each of the at least one flat shaped wires to create at least one flat lumen; placing a braided wire assembly over the inner liner and the at least one flat lumen; covering the braided wire assembly with a melt processing polymer; applying sufficient heat to the melt processing polymer to raise the temperature of the polymer above its melting point; cooling the assembly; and removing the mandrel, thereby forming a catheter. Typically, the catheter is manufactured such that it has a cross-section with an outer shape that is substantially circular with an outer diameter of less than about 12F. Optionally, the melt processing polymer may be covered with shrink wrap tubing to help promote the polymer flowing through the braided wire assembly. The shrink wrap tubing may be left in place after manufacturing, or it may be removed as part of the manufacturing process. The melt processing polymer is typically selected from Nylon, Pebax and other thermal elastomers. Optionally, additional layers of melt processing polymers may be placed over the flat lumen and the inner liner. Typically, the flat wire and the flexible liner being placed over the flat wire will each have different cross-sectional shapes.
- Also disclosed is a method of manufacturing a steerable introducer catheter, including the steps of: providing a mandrel; laminating the mandrel with a lining material to form an inner liner; providing at least one flat shaped wire; covering the inner liner and the at least one flat shaped wire with a melt processing polymer; applying sufficient heat to the melt processing polymer to raise the temperature of the polymer above its melting point; cooling the assembly; and removing the mandrel, thereby forming a steerable introducer catheter. Optionally, a flexible tube is placed over each of the at least one flat shaped wires to create at least one corresponding lumen for each of the wires, and further, the melt processing polymer may be covered with a layer of shrink wrap tubing. The braided wire assembly may be characterized by a braid density that transitions from a first number at the base to a lower number at the tip. The variation in braid density may range from about 50 PPI at the base to about 10 PPI at the distal end.
- In accordance with another aspect of the present invention, a catheter or an introducer catheter for cardiac surgery comprises a tubular inner liner, a torque transfer layer, or reinforcing layer, surrounding at least a portion of the inner liner, the torque transfer layer comprising at least two flat wires braided into a wire mesh, and an outer sheath formed over to the torque transfer layer. The flat wires are substantially rectangular in cross-section and have a width of at least about 0.007 inches and a depth of at least about 0.003 inches. The tubular inner liner has a lumen diameter of at least about 6 French. In specific embodiments, the catheter is an introducer catheter. The tubular inner liner is polymeric and the outer sheath comprises a melt-processing polymer. The ratio of width to thickness of the introducer catheter may be between about 2:1 and about 5:1. The torque transfer layer has a braid density of between about 5 PPI and about 100 PPI and may be braided in a one-over, one-under pattern, or a two-over, two-under pattern. The outer sheath comprises a plurality of segments having differing hardness characteristics, and the segments are reflow bonded together.
- The catheter assembly of the present invention may also include a pull ring to which the at least two flat wires are secured. The pull ring may be a right circular cylinder having a slot for each of the at least two flat wires. Typically, there are two flat wires, the pull ring has two slots spaced on opposite sides of the pull ring, and each of the flat wires is secured in the slot by a laser weld. The pull ring may further include at least two flow holes such that the outer layer will bond to the pull ring during melt processing as the melt processing polymer flows through the flow holes and then becomes rigid after cooling.
- The catheter assembly of the present invention may also include a shaft made of at least three segments, wherein each segment has a different hardness characteristic. For example, a first shaft segment may be made of nylon, a second segment may be made of a first Pebax, and a third segment may be made of a second Pebax that is more flexible than both the nylon and the first Pebax. Additional segments may be used to form the shaft, each of which may have greater or lesser degrees of stiffness.
- Also disclosed is a pull ring assembly for a catheter including a pull ring having at least one rectangular slot and at least one flat pull wire, wherein each of the at least one flat pull wires is secured to the at least one rectangular slot of the pull ring. Typically, the pull ring assembly will include at least two slots and at least two flat pull wires secured in the slots. Optionally, the pull ring may include flow holes though which a melt processing polymer may flow during lamination.
- According to still another embodiment of the invention, a pull ring assembly includes a pull ring having at least two rectangular slots and at least two pull wires, wherein each of the at least two pull wires is secured to the rectangular slot of the pull ring. Optionally, the pull ring may include flow holes though which a melt processing polymer may flow during lamination.
- A technical advantage of the present invention is that overall cross-section of the catheter may be reduced.
- Another technical advantage of the present invention is that a steerable catheter using flat pull wires may be provided that enjoys greater flexibility.
- Yet another technical advantage of the invention is it may utilize an improved braided wire assembly that provides for greater flexibility and control of a catheter.
- A further technical advantage of the invention is that a method of manufacturing an improved steerable catheter is provided.
- Yet another technical advantage of the invention is that a catheter shaft having greater flexibility and control may be utilized.
- A further technical advantage of the invention is that a method of manufacturing an introducer with a lower profile outer diameter with improved steerability is provided.
- The foregoing and other aspects, features, details, utilities, and advantages of the present invention will be apparent from reading the following description and claims, and from reviewing the accompanying drawings.
-
FIG. 1 is perspective view of an embodiment of a catheter of the present invention. -
FIG. 2 illustrates a perspective view of a section of a catheter according to an embodiment of the present invention, cut away to show details. -
FIG. 3 is a cross-sectional view taken along line 3-3 inFIG. 2 . -
FIG. 4 is a cross-sectional view taken along line 4-4 inFIG. 2 . -
FIG. 5 is a cross-sectional view taken along line 5-5 inFIG. 2 . -
FIG. 6 is a cross-sectional view of a catheter assembly prior to the application of heat to melt process the outer layer. -
FIG. 7 is a cross-sectional view of a catheter after the application of heat to melt process the outer layer. -
FIG. 8 illustrates a perspective view of a partially assembled catheter in accordance with another embodiment of the invention, cut away to show details. -
FIG. 9 illustrates a pull ring that may be used in a catheter according to the present invention. -
FIG. 10 is a sectional view of the pull ring ofFIG. 9 taken along line 10-10. -
FIG. 11 is a cross-sectional view of a steerable, large bore introducer in accordance with another embodiment of the present invention. -
FIG. 12 depicts a reflow mandrel assembly used in the method of manufacturing introducers in accordance with the present invention. -
FIG. 13 depicts an inner layer disposed over a reflow mandrel assembly in accordance with a preferred method of manufacture. -
FIG. 14 depicts a torque transfer layer disposed over an inner layer in accordance with a preferred method of manufacture. -
FIG. 15 depicts an outer sheath of varying components disposed over a torque transfer layer in accordance with a preferred method of manufacture. -
FIG. 16 depicts the components of an introducer assembled over a reflow mandrel assembly having a distal configuration for a tip assembly. -
FIG. 17 depicts a tip component, having a radiopaque marker, attached to the distal end of the introducer depicted inFIG. 16 . -
FIG. 18 depicts another tip component, having a radiopaque marker, attached to the distal end of the introducer depicted inFIG. 16 . - Flat Pull Wires
- The present invention provides an improved steerable catheter that minimizes the overall outer dimensions by utilizing a variety of improved techniques. One technique is to utilize flat wire as the pull wires for the steerable catheter.
- For purposes of this invention, a “flat wire” or a “flat pull wire” refers to a wire that is characterized by a cross-section that, when measured along two orthogonal axes, is substantially flat. A flat wire typically has a rectangular cross-section. For example, the rectangular cross-section may be approximately 0.004″×0.012″. The cross-section need not be perfectly rectangular. For example, the present invention contemplates a cross-section of the flat wire may be oval, provided that the overall cross-section is generally flat. For example, a wire may be properly characterized as a flat wire if it has a cross-section that is measured X in one direction and at least 3X in a second direction generally orthogonal to the first direction. A wire whose cross-section is substantially I-shaped may also be a flat wire if, generally, its height is substantially greater than its width at its widest measurement. One of ordinary skill will appreciate that a flat wire may be defined in the context of the overall teachings of this application.
- The use of a flat wire as a pull wire also has the added benefit that it provides greater resistance to deflection in certain directions. The shape of a round wire is not predisposed to resist deflection in any particular direction, whereas the shape of a flat wire will be predisposed to resist deflection on a first axis, and yet predisposed to permit deflection on a second axis that is orthogonal to the first axis. Thus, by using a pull wire that is not circular, a catheter can be predisposed to permit and favor deflection in one direction over another.
- The outer diameter of the catheter may also be minimized at the distal tip by an improved braided wire assembly. In particular, a braid may be used that is characterized by a varying braid density from the proximal end to the distal tip. Preferably, the braid is less dense at the tip than at the proximal end of the catheter. Some applications may be better suited if the braid density is more dense at the tip than at the proximal end, while other applications may be better suited if the braid density is greater on both ends than in the middle of the catheter.
-
FIG. 1 is a perspective view of acatheter assembly 110 according to one embodiment of the present invention comprising a catheter or anintroducer catheter 100 having aproximal portion 110 and adistal portion 190. Thecatheter 100 may be operably connected to ahandle assembly 106 which assists in guiding or steering the introducer during procedures. Thecatheter assembly 110 further includes ahub 108 operably connected to an inner lumen (not shown) within thehandle assembly 106 for insertion or delivery of catheter assemblies, fluids, or any other devices known to those of ordinary skill in the art. Optionally, thecatheter assembly 110 further includes avalve 112 operably connected to thehub 108. -
FIG. 2 illustrates a perspective view of a catheter according to a preferred embodiment of the present invention, cut away to show details. - The basic method of manufacture of
catheter 100 according to an embodiment of the present invention will be described with reference toFIGS. 2, 3 , 4, 6, 7 and 8. As they are assembled, the catheter components will be collectively referred to as a catheter assembly. - As depicted in
FIG. 6 , amandrel 10, which is preferably round in cross-section and preferably from about 6 inches to about 4 feet in length, is a component of thecatheter assembly 200, and may be the first component thereof during manufacture ofcatheter 100.Mandrel 10 has a distal end and a proximal end. Aninner liner 20 is placed onmandrel 10.Inner liner 20 may be knotted at one end (e.g. the distal end) and then fed ontomandrel 10. - Preferably,
inner liner 20 is an extruded polytetrafluoroethylene (PTFE) tubing, such as Teflon® brand tubing, which is available commercially.Inner liner 20 may also be made of other melt processing polymers, including, without limitation, etched polytetrafluoroethylene, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax®, made by Arkema, Inc. Pebax of various durometers may be used, including, without limitation, Pebax 30D to Pebax 70D. In a preferred embodiment,inner liner 20 is made of a material with a melting temperature higher than that of anouter layer 60, which will be further described below, such thatinner liner 20 will withstand melt processing ofouter layer 60. - A
flat wire 30 is placed longitudinally alonginner liner 20.Flat wire 30 is preferably composed of stainless steel and is preferably about 0.002″ by about 0.016″, and more preferably about 0.004″ by about 0.012″. In one embodiment, at least a portion offlat wire 30 is encased inside another preformedtube 40 before placement alonginner liner 20 to form aflat lumen 42.Preformed tube 40 need not have the same shape as the cross-section offlat wire 30, but instead may be round, oval, rectangular, or another like shape. Preferably, preformedtube 40 has a cross-section that is not the same shape as the cross-section offlat wire 30 in order to facilitate movement offlat wire 30 in preformedtube 40.Preformed tube 40 may be formed of polytetrafluoroethylene, polyether block amides, nylon, other thermoplastic elastomers, or another substance. Preferably, preformedtube 40 has a higher melting point thanouter layer 60, which will be further described below, so that preformedtube 40 will not melt whenouter layer 60 is subjected to melt processing. - In alternative embodiments,
flat wire 30 may be covered with lubricious materials including silicone, Teflon®, siloxane, and other lubricious materials (not shown), before placement. Alternatively,flat wire 30 may also be coated with a lubricious layer to promote slideability. It is also contemplated thatflat wire 30 may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material from which to composeflat wire 30, other materials may be used, including, without limitation, materials that are used for conventional round pull wires. - More than one
flat wire 30 may also be used. In such cases, each suchflat wire 30 may be encased inside its ownflexible tube 40 to form separateflat lumens 42. Preferably, a pair offlat wires 30 are used, spaced apart about 180 degrees about the circumference ofinner liner 20. -
Outer layer 60 is then placed overinner liner 20,flat wires 30, and preformedtube 40 formingflat lumen 42.Outer layer 60 may be made of either single or multiple sections of tubing that may be either butted together or overlapped with each other. Preferably,outer layer 60 is an extruded polytetrafluoroethylene tubing, such as Teflon® brand tubing, which is available commercially.Outer layer 60 may also be made of other melt processing polymers, including, without limitation, etched polytetrafluoroethylene, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax® made by Arkema, Inc. Pebax of various durometers may be used, including, without limitation, Pebax 30D to Pebax 70D.Outer layer 60 may also comprise more than one layer, including for example two or more tubes of a melt processing polymer. - Optionally, a
braided wire assembly 50 may be placed overinner liner 20 and anyflat wires 30 beforeouter layer 60 is applied.Braided wire assembly 50 may be formed of stainless steel wire, including for example 0.003″ high tensile stainless steel wire.Braided wire assembly 50 may be formed in a standard braid pattern and density, for example, about 16 wires at about 45 to about 60 picks per inch (“PPI”) density. Alternatively, a braid may be used that is characterized by a varying braid density. For example, braidedwire assembly 50 may be characterized by a first braid density atproximal end 110 ofcatheter 100 and then transition to one or more different braid densities as braidedwire assembly 50 approachesdistal end 190 ofcatheter 100. The braid density ofdistal end 190 may be greater or less than the braid density atproximal end 110. In a specific example, the braid density at the base (i.e., proximal end 110) is about 50 PPI and the braid density atdistal end 190 is about 10 PPI. In another embodiment, the braid density atdistal end 190 is about 20% to about 35% of the braid density at the base/proximal end 110. -
Braided wire assembly 50 may be formed separately on a disposable core. One or more portions of braidedwire assembly 50 may be heat tempered and cooled before incorporation intocatheter assembly 200 though methods that are known to those of ordinary skill. The action of heat tempering may help to release the stress on the wire and help reduce radial forces. -
FIG. 6 displays a cross-section ofcatheter assembly 200 having twoflat wires 30 and braided wiredassembly 50 encompassed byouter layer 60 before lamination of the materials by heating. In one preferred embodiment, a layer of heat shrink 70 is placed over the top ofouter layer 60 as depicted inFIG. 6 . Heat shrink 70 is preferably a fluoropolymer or polyolefin material. -
FIG. 7 depictscatheter assembly 200 after a lamination process.Catheter assembly 200 may be laminated byheating catheter assembly 200 until the material comprisingouter layer 60 flows and redistributes around the circumference thereof as depicted inFIG. 7 . Heat shrink 70 has a higher melting temperature thanouter layer 60; and during the melt process, heat shrink 70 retains its tubular shape and forces the liquefiedouter layer 60 material into braided wire assembly 50 (if present) and into contact withflat wires 30 andinner liner 20.Catheter assembly 200 may then be cooled. InFIG. 7 ,mandrel 10 is still in place. -
Mandrel 10 may be removed fromcatheter assembly 200, leaving behind alumen 80 as illustrated inFIG. 4 , which depicts acatheter 100 made in accordance with the method of the present invention subsequent to the application of heat for the lamination process. Optionally, heat shrink 70 may be left in place aroundouter layer 60, as depicted inFIG. 7 , even aftermandrel 10 is removed. - If heat shrink 70 is removed,
outer layer 60 becomes the outermost layer ofcatheter 100. The result is a substantiallycircular catheter 100 withpull wires 30 embedded within outer layer material as illustrated inFIGS. 3 and 4 .FIG. 3 is a cross-sectional view taken at the point of apull ring 90 as depicted inFIG. 2 , whileFIG. 4 is a cross-sectional view taken at a point proximal to pullring 90.FIG. 8 is a perspective view ofcatheter assembly 200, cut away to show certain details of construction. -
Catheter assembly 200 may be manufactured using alternative techniques. In one embodiment,outer layer 60 may be formed by extrudingouter layer 60 overcatheter assembly 200. - In another embodiment,
catheter assembly 200 may formed by using a combination of heat and a press that has a mold for defining the final shape ofcatheter 100. -
Catheter 100 formed using the methods of this invention may have varying sizes and various uses. For example,catheter 100 may be used in atrial fibrillation cases as well as atrial tachycardia cases. In connection with certain heart applications,catheter 100 manufactured using the improvements discussed herein is preferably less than about 12F outer diameter, and more preferably less than about 10F outer diameter. For use as a steerable introducer, a catheter size of less than about 11F outer diameter may be preferred. As discussed below, larger catheter sizes are feasible, particularly when the torque transfer layer is made of braided flat wires. - In another embodiment,
catheter 100 construction may be modified to utilize materials of various durometer hardness (as measured, for example, using a Shore durometer hardness scale). For example,proximal end 110 ofcatheter 100 may be made of a material such as nylon 11, and the remainder ofcatheter 100 may be made of one or more Pebax materials. Preferably, the durometer hardness levels will decrease ascatheter 100 shaft approachesdistal end 190. For example, a nylon base may then be followed by one or more of the following Pebax segments: 70D Pebax; 60D Pebax; 55D Pebax; 40D Pebax; 35D Pebax; 30D Pebax.Catheter 100 may also use one or more blends of the foregoing Pebax materials, including for example, a 70D/60D Pebax blend made by co-extrusion, or a 40D/35D Pebax blend made by co-extrusion. Preferably,catheter 100 made with one or more segments of varying durometers will be reflowed together during manufacturing. The length of the segments may vary.Proximal end 110 ofcatheter 100 is preferably the longest segment, and more distal segments may preferably vary between about 0.25″ to about 6″, and more preferably from about 0.25″ to about 3″. Preferably, the hardness levels of the segments and the lengths of the segments may be adjusted for specific applications, and preferably, the distal tip segment may have the lowest durometer of all segments. The segments may be selected to optimize stability and torque delivery for the specific application. -
FIG. 5 illustrates another embodiment of the invention in whichouter layer 60 is composed ofmultiple segments segment 61 has the greatest degree of hardness;segments segment 61;segments segments segment 64 is more flexible than each ofsegments - In yet another embodiment, a modified
braided wire assembly 50 is inserted betweeninner liner 20 andouter layer 60.Braided wire assembly 50 may be designed to have transitional braid densities starting at one braid density and transitioning to a lower braid density. In one embodiment, the braid may begin at a braid density of about 50 to about 60 PPI, and more preferably between about 50 and about 55 PPI, and then transition to a braid density at the tip of about 5 to about 20 PPI, and more preferably between about 5 to about 15 PPI. The braid density may transition slowly, or it may change using one or more segments. For example, there may be an intermediate zone with a braid density of about 30 to about 45 PPI. Variations in the braid density of braidedwire assembly 50 may be used to increase or decrease flexibility ofcatheter 100 depending on the desired application. - In another embodiment, pull
ring 90 is utilized to provide steerability.FIGS. 9 and 10 illustrate a preferred embodiment forpull ring 90. Pullring 90 is a generally circular band with a cross-sectional shape (measured orthogonally to a tangential line relative to the circle of the band) that is substantially rectangular. The rectangular cross-section is more clearly depicted inFIG. 10 . The outer dimension ofpull ring 90 is preferably determined based on the application forcatheter 100 to be manufactured. In one embodiment, pullring 90 is about 0.10″ in diameter. - Pull
ring 90 preferably has at least oneslot 91 that is configured to accommodateflat pull wire 30.Flat pull wire 30 may secured withinslot 91 by any technique that is appropriate given the materials ofpull ring 90 andflat pull wires 30. Acceptable techniques may include, but are not limited to, laser welding and/or other welding and bonding techniques. - In another embodiment, pull
ring 90 may contain one or more flow holes 95 as illustrated inFIGS. 9 and 10 . During a melting process, the material ofouter layer 60 melts and flows through flow holes 95. Upon cooling, the material ofouter layer 60 bonds to pullring 90 to provide better adhesion betweenpull ring 90 and the remaining components ofcatheter assembly 200, thereby improving performance ofcatheter 100. While flow holes 95 are depicted as circular, other shapes may be used. In one embodiment, pullring 90 includes two 0.025″ flow holes 95 spaced about 180 degrees apart around the circumference ofpull ring 90. The size and shape of flow holes 95 may be adjusted based on the materials being used to forminner liner 20 and/orouter layer 60. - In another embodiment, pull
ring 90 is utilized with non-flat pull wires. Pullring 90 of this embodiment is preferably a circular band with a cross-sectional shape (measured orthogonally to a tangential line relative to the circle of the band) that is substantially rectangular. Preferably, pullring 90 has at least one slot that is configured to accommodate a non-flat pull wire (such as a round wire). Preferably, the tip of the non-flat pull wire is tapered to facilitate joinder withpull ring 90. The non-flat pull wire may be secured within the slot by any technique that is appropriate given the materials ofpull ring 90 and the pull wires. Acceptable techniques may include, but are not limited to, laser welding and/or other welding and bonding techniques. Preferably, the non-flat pull wire is located within a preformed tube. The preformed tube need not be the same shape as the cross-section of the pull wire, but instead, may be round, oval, rectangular, or another like shape. Preferably, the preformed tube has a cross-section that is not the same shape as the cross-section of the pull wire in order to facilitate movement of the pull wire in the preformed tube. The preformed tube may be formed of polytetrafluoroethylene, polyether block amides, nylon, other thermoplastic elastomers or another substance. Preferably, the preformed tube has a higher melting point thanouter layer 60 so that the preformed tube will not melt whenouter layer 60 is subjected to melt processing. In alternative embodiments, the pull wire may be covered with lubricious materials, such as silicone and other lubricious materials, before placement. Alternatively, the pull wire may be coated with a lubricious layer to promote slideability, and it is also contemplated that the pull wire may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material to compose the pull wire, other materials may be used, including, without limitation, materials that are used for conventional pull wires. - Pull
ring 90 is typically utilized neardistal end 190 ofcatheter 100, but it is anticipated that pullring 90 may be located at any position alongcatheter 100. Moreover, more than onepull ring 90 may be utilized in thesame catheter 100. In one embodiment ofcatheter 100, two separate pull rings 90 may be utilized, each of which has its ownflat pull wires 30 connected thereto. - Although multiple embodiments of this invention have been described above with a certain degree of particularity, those skilled in the art could make numerous alterations to the disclosed embodiments without departing from the spirit or scope of this invention. For example, pull
ring 90 may be made of stainless steel or other materials, including, without limitation, materials that are used to form conventional pull ring assemblies. In addition, braidedwire assembly 50 may be made of stainless steel or other materials, including materials that are used to form conventional braided wire assemblies. - Torque Transfer Layer Using Braided Flat Wires
- The present invention further provides a torque transfer layer using braided flat wires for a catheter and a large bore introducer catheter. For purposes of description, embodiments of the present invention will be described in connection with a flat wire guided, or steerable, introducer catheter. It is contemplated, however, that the described features may be incorporated into any number of catheters or introducer catheters as would be appreciated by one of ordinary skill in the art. The large bore introducer catheter is comprised of a combination of components and manufactured by either a reflow process or an extrusion process, which provide the surprising benefits of allowing for introducer catheters having an internal diameter of at least about 6 French while maintaining the desirable improved properties of pushability, torqueability, and flexibility, for outer diameters of sufficient size for navigation of cardiac vasculature.
-
FIG. 11 depicts a cross-sectional view of anintroducer catheter 1200 in accordance with one embodiment of the present invention. Theintroducer catheter 1200 is comprised of a tubular polymericinner liner 1202, atorque transfer layer 1204, anouter sheath 1206 comprised of a melt-processing polymer, and aheat shrink layer 1208. In the instance where the introducer is a steerable introducer, theintroducer catheter 1200 further includes at least oneflat wire 1210 disposed longitudinally along the length of theintroducer catheter 1200. For purposes of this invention, a “flat wire” refers to a wire that is characterized by a cross-section that, when measured along two orthogonal axes, is substantially flat. A flat wire typically has a rectangular cross section, though the cross section need not be perfectly rectangular. For example, the present invention contemplates that a cross section of the flat wire may be oval, provided that the overall cross section is generally flat. As the term is used herein, a wire may be properly characterized as a flat wire if it has a cross section that is measured x in one direction and at least 2x in a second direction generally orthogonal to the first direction. A wire whose cross section is substantially I-shaped may also be a flat wire if, generally, its height is substantially greater than its width at its widest measurement. One of ordinary skill will appreciate that a flat wire may be defined in the context of the overall teachings of this application. - The at least one
flat wire 1210 may be further encased inside anotherpolymeric tubular member 1212 forming alumen 1214 for housing theflat wire 1210. The introducer catheter according to this embodiment is manufactured by a reflow bonding process in which the components are individually fed over a mandrel as discussed in more detail below. - The
inner liner 1202 is preferably a polymeric material, such as polytetrafluoroethylene (PTFE) or etched PTFE. Theinner liner 1202 may also be made of other melt processing polymers, including, without limitation, polyether block amides, nylon and other thermoplastic elastomers. Once such elastomer is Pebax® made by Arkema, Inc. Pebax of various durometers may also be used, including without limitation, Pebax 30D to Pebax 70D. In a preferred embodiment, theinner liner 1202 is made of a material with a melting temperature higher than theouter sheath 1206 such that theinner liner 1202 will withstand the melt processing of theouter sheath 1206. -
Inner liner 1202 defines alumen 1216 therethrough, preferably having adiameter 1218 of at least about 6 French, more preferably of at least about 7 French, and most preferably of between about 10 French and about 24 French. However, in some embodiments of the invention, it is contemplated thatlumen 1216 may have adiameter 1218 of up to about 32 French or more, such as between about 7 French and about 32 French. - A
torque transfer layer 1204 is preferably disposed between theinner liner 1202 and theheat shrink layer 1208, more preferably between theouter sheath 1206 and theinner liner 1202. In the instance where the introducer is a steerable introducer utilizing, for example, at least onelongitudinal wire 1210, thetorque transfer layer 1204 may be disposed either between theinner layer 1202 and theouter sheath 1206 or between theouter sheath 1206 and theheat shrink layer 1208. Thetorque transfer layer 1204 may be made of stainless steel (304 or 316) wire or other acceptable materials kown to those of ordinary skill in the art. - The
torque transfer layer 1204 is preferably formed of a braided wire assembly comprised of flat wires, preferably stainless steel wires including, for example, high tensile stainless steel wires. Thetorque transfer layer 1204 may be formed in any number of known braid patterns, including one-over-one (involving at least two wires) or two-over-two (involving at least four wires) crossover patterns. The braided flat wires typically have a thickness of at least about 0.0005″ and a width of at least about 0.005″. Examples of larger sizes include 0.001″×0.005″ and 0.002″×0.006″. For lumen diameters of at least about 6 French, braided flat wires of at least about 0.003″ thick by at least about 0.007″ wide, which heretofore were not used to form a wire mesh for the torque transfer layer, have produced surprisingly good results of increased pushability, torqueability, flexibility, and kink resistance over non-flat wires and smaller flat wires. In general, the individual wires have a ratio of width to the thickness of at least about 2:1, including, for example, 2:1 to 5:1. Flat wires of about 0.004″ thick by about 0.012″ wide and of about 0.004″ thick by about 0.020″ wide have also been braided with success to form torque transfer layers of superior performance. - The braid density, commonly measured in pixels per inch (“PPI”), is typically between about 5 and 100, and will depend on the size of the flat wires as well as the size of the catheter. For flat wires of at least about 0.003″ thick by about 0.007″ wide and a catheter having an inner lumen of at least about 6 French, the PPI is preferably between about 10 and about 90, more preferably between about 10 and about 55. For example, the PPI for flat wires of about 0.003″ thick by about 0.007″ wide is preferably between about 20 and about 90, more preferably between about 35 and about 55 for an inner lumen of at least 6 French, and most preferably between about 35 and about 45 for an inner lumen of at least about 10 French. The PPI for flat wires of about 0.004″ thick by about 0.012″ wide is preferably between about 15 and about 70, and more preferably between about 15 and about 22 for an inner lumen of at least about 6 French. The PPI for flat wires of about 0.004″ thick by about 0.020″ wide is preferably between about 5 and about 50, and more preferably between about 10 and about 20 for an inner lumen of at least about 6 French, and most preferably between about 10 and about 20 for an inner lumen of at least about 16 French.
- Alternatively, the
torque transfer layer 1204 may utilize a varying braid density construction along the length of theintroducer catheter 1200. For example, the torque transfer layer may be characterized by a first braid density at the proximal end of theintroducer catheter 1200 and then transition to one or more braid densities as thetorque transfer layer 1204 approaches the distal end of theintroducer catheter 1200; the braid density of the distal end may be greater or less than the braid density at the proximal end. In a specific example, the braid density at the proximal end is about 50 PPI and the braid density at the distal end is about 10 PPI. In another embodiment, the braid density at the distal end is about 20-35% of the braid density at the proximal end. - The
torque transfer layer 1204 may be formed separately on a disposable core and subsequently slipped around theinner liner 1202. One or more portions of thetorque transfer layer 1204 may be heat tempered and cooled before incorporation into theintroducer body 1200 through methods that are known to those of ordinary skill. The action of heat tempering may help to release the stress on the wire and help reduce radial forces. It is also contemplated thattorque transfer layer 1204 may be braided directly on theinner liner 1202. - A particularly preferred
torque transfer layer 1204 is comprised of 0.003″ by 0.007″ 304 stainless steel wires at 35 PPI for an inner lumen of 6-10 French. Another preferredtorque transfer layer 1204 is comprised of 0.004″ by 0.012″ 304 stainless steel wires at 22 PPI for an inner lumen of 12 French. Yet another preferredtorque transfer layer 1204 is comprised of 0.004″ by 0.020″ 304 stainless steel wires at 13 PPI for an inner lumen of 16 French. These particularly preferred torque transfer layers may manufactured on a commercially available horizontal braid machine set at 225 rpm utilizing a commercially available mandrel. Other suitable methods of manufacturing thetorque transfer layer 1204 will be apparent to those of ordinary skill in the art. - The
outer sheath 1206 is preferably either an extruded Pebax or PTFE tubing. The melt-processing polymer of theouter sheath 1206 occupies a plurality of voids of the wire mesh in the torque transfer layer. Theouter sheath 1206 may also be made of other melt processing polymers, including, without limitation, etched PTFE, polyether block amides, nylon and other thermoplastic elastomers, at varying durometers. Theouter sheath 1206 may also comprise more than one layer, including, for example, two or more tubes of a melt processing polymer. Alternatively, as shown inFIG. 15 , theouter sheath 306 may be comprised of varyingsegments introducer 300 and being reflow bonded together. This may be accomplished by layering or by placing annular rings of differing materials along the length of theintroducer 300. Varying the sheath composition in this manner provides the additional benefit of adjusting flexibility, torqueability, and pushability at various points along theintroducer 300. - In embodiments where the introducer is a steerable introducer (as shown in
FIG. 11 ), at least oneflat wire 1210 is provided, preferably extending along substantially the entire length of the introducer. Theflat wire 1210 is preferably composed of stainless steel and is preferably about 0.002″× about 0.016″, and more preferably about 0.004″× about 0.012″ or 0.016″. The flat wire may be selected such that the ratio of the width to thickness is at least about 2:1. In one embodiment, at least a portion of the flat wire is encased inside a preformedtube 1212 before placement along theinner liner 1202 to form aflat lumen 1214. The preformedtube 1212 need not be the same shape as the cross section of the flat wire, but instead, may be round, oval, rectangular, or another like shape. Preferably, the preformedtube 1212 has a cross section that is not the same shape as a cross section of theflat wire 1210, in order to facilitate movement of the flat wire in the preformed tube. The preformed tube may be formed of PTFE, etched PTFE, polyether block amides (such as Pebax), nylon, other thermoplastic elastomers, or any other known material to one of ordinary skill in the art. Preferably, the preformedtube 1212 has a higher melting point than theouter sheath 1206 so that the preformedtube 1212 will not melt when theintroducer catheter 1200 is subjected to melt processing. In alternative embodiments theflat wire 1210 may be covered with lubricious materials (not shown) before placement, including silicone and other lubricious materials. Alternatively, theflat wire 1210 may also be coated with a lubricious layer to promote slideability, and it is also contemplated that theflat wire 1210 may be manufactured with a smooth surface to promote slideability. While stainless steel is a preferred material to compose theflat wire 1210, other materials may be used, including, without limitation, materials that are used for conventional round pull wires. More than oneflat wire 1210 may also be used, and in such cases, each suchflat wire 1210 may be encased inside its ownflexible tube 1212. Preferably, as shown inFIG. 11 , a pair offlat wires 1210 are used that are spaced at 180 degrees apart. Theflat wires 1210 are preferably connected to at least one steering ring typically located near the distal end of the introducer (see, e.g., similarflat wires 30 connected to steeringring 90 inFIG. 2 ). The proximal ends of theflat wires 1210 are then operably connected to a steering mechanism (not shown) allowing for manipulation, or steering, of theintroducer catheter 1200 during use. - The basic method of manufacture according to an embodiment of the present invention will be described in reference to
FIGS. 12-18 . As the various components are assembled, the introducer components will be collectively referred to as an introducer. As depicted inFIGS. 12-18 , amandrel 300, which is preferably round in cross-section and preferably from about 6 inches to about 4 feet in length, is provided. As depicted inFIG. 12 , themandrel 300 has adistal end 350 and aproximal end 352. As depicted inFIG. 13 , aninner liner 302 is placed on themandrel 300. Theinner liner 302 is fed on to themandrel 300 and is then knotted on oneend 320, or both ends. - As depicted in
FIG. 14 , atorque transfer layer 304 is then placed over theinner liner 302. In the case of a steerable introducer catheter, the flat wire assembly (not shown) may then be placed over thetorque transfer layer 304. Alternatively, the flat wire assembly may be placed over anouter sheath 306. Another sheath layer (not shown) may additionally be placed over the flat wire assembly. The torque transfer layer terminates proximally of the distal end of the catheter. - Next, as depicted in
FIG. 15 , anouter sheath 306 is placed over thetorque transfer layer 304 and may be made of either single or multiple sections of tubing that are either butted together or overlapped with each other. The multiple segments, or layers, of sheath material may be any length and/or hardness (durometer) allowing for flexibility of design.FIG. 15 identifies a plurality of segments, 322, 324, 326, 328 and 330. In this embodiment, theproximal end 330 of theouter sheath 306 may be made of a material such as nylon, and the remainder of the introducer may be made of one or more Pebax materials. The lengths of the various segments may vary, but preferably, the durometer hardness levels will decrease as theouter sheath 306 approaches its distal end. For example, a nylon base may then be followed by one or more of the following Pebax segments: 70D Pebax; 60D Pebax; 55D Pebax; 40D Pebax; 35D Pebax; 30D Pebax. The introducer shaft may also use one or more blends of the foregoing Pebax materials, including, for example, 70D/60D Pebax blend made by co-extrusion, or a 40D/35D Pebax blend made by co-extrusion. Preferably, the various components of theouter sheath 306 according to this embodiment will be reflowed together during manufacturing. The proximal end of the shaft is preferably the longest segment, and more distal segments may preferably vary between 0.25″ to 6″, and more preferably from 0.25″ to about 3″. Preferably, the hardness levels of the segments and the lengths of the segments may be adjusted for specific applications, and preferably, the distal end may have the lowest durometer levels of all segments. The shaft segments may be selected to improve flexibility, torqueability, and pushability for the specific application, as appreciated by one of ordinary skill in the art. Alternatively, the catheter may be formed by placing a thin inner jacket or layer (e.g., PTFE layer) onto a mandrel (e.g., stainless steel mandrel) or extruding a thin inner jacket or layer (e.g., Pebax layer) onto an extrusion mandrel (e.g., acetal mandrel), forming a torque transfer layer over the inner layer, and extruding an outer jacket or sheath (e.g., Pebax jacket) over the torque transfer layer. - Lastly, a
heat shrink layer 308 is placed over the assembled introducer assembly prior to reflow lamination. Theheat shrink layer 308 is preferably a fluoropolymer or polyolefin material, such as FEP, or other suitable material as appreciated by one of ordinary skill in the art. - After assembly of the various components, the
introducer assembly 300 is subjected to a reflow lamination process.FIG. 11 depicts a cross sectional view of the introducer assembly after this reflow process.Introducer assembly 1200 may be laminated by heating the assembly until the material comprising theouter sheath 1206 flows and redistributes around the circumference. Preferably, theheat shrink layer 1208 has a higher melt temperature than theouter sheath 1206, and during the melt process, theheat shrink layer 1208 retains its tubular shape and forces the liquefiedsheath layer material 1206 into thetorque transfer layer 1204 and into contact with theflat wires 1210/preformed tubes 1212 (if present) and theinner liner 1202. Theintroducer assembly 1200 may then be cooled. The mandrel is preferably left in place during the cooling process as it helps the introducer assembly to retain its inner lumen of at least about 6 French. Theheat shrink layer 1208 may be left on theintroducer assembly 1200, or optionally removed. If theheat shrink layer 1208 is removed, theouter sheath 1206 becomes the outside layer of theintroducer catheter 1200. - Additionally, as shown in
FIGS. 16-18 , the present invention contemplates the inclusion of a tip assembly for use in medical procedures, such as an atraumatic tip, including, for example, a radiopaque material contained therein for location of the tip during use. For example,FIGS. 16-18 depict a cross section of anintroducer catheter 700 having adistal portion 730 configured to accept atip assembly tip ring 736, e.g., a radiopaque marker, for location of thetip FIG. 18 further includes atip assembly 734 configured with a plurality of port holes 738 for delivery of, for example, irrigation fluid. The tip assembly may further be configured with ablation electrodes (not shown) operably connected to a power supply (not shown), for use in cardiac ablation procedures. - Although several embodiments of this invention have been described above with a certain degree of particularity, those skilled in the art could make numerous alterations to the disclosed embodiments without departing from the spirit or scope of this invention. All directional references (e.g., upper, lower, upward, downward, left, right, leftward, rightward, top, bottom, above, below, vertical, horizontal, clockwise, and counterclockwise) are only used for identification purposes to aid the reader's understanding of the present invention, and do not create limitations, particularly as to the position, orientation, or use of the invention. Joinder references (e.g., attached, coupled, connected, and the like) are to be construed broadly and may include intermediate members between a connection of elements and relative movement between elements. As such, joinder references do not necessarily infer that two elements are directly connected and in fixed relation to each other. It is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative only and not limiting. Changes in detail or structure may be made without departing from the spirit of the invention as defined in the appended claims.
Claims (25)
1. A catheter assembly, comprising:
an inner liner made of flexible material; and
an outer layer having a steering mechanism, the steering mechanism comprising:
at least one flat wire; and
a corresponding lumen for each of the at least one flat wire through which the flat wire may travel;
wherein the outer layer comprises a braided wire assembly that includes at least two flat wires braided into a wire mesh.
2. The catheter assembly of claim 1 , further comprising a layer of heat shrink material encompassing the outer layer, wherein the inner liner includes a central lumen, and wherein the catheter assembly has a cross section with an outer shape that is substantially circular.
3. The catheter assembly of claim 2 , further comprising at least one pull ring to which the at least one flat wire is secured, whereby the catheter assembly may be steered by controlling the at least one flat wire.
4. The catheter assembly of claim 3 , wherein the outer layer comprises a melt processing polymer, wherein the steering mechanism comprises a pull ring to which the at least one flat wire is secured, and wherein the pull ring comprises at least two flow holes, said outer layer being bonded to the pull ring such that the melt processing polymer occupies the at least two flow holes.
5. The catheter assembly of claim 3 , wherein the steering mechanism comprises at least two flat wires and at least two corresponding preformed tubes through which the at least two flat wires may travel, wherein the at least two flat wires are secured to the at least one pull ring, and wherein the at least two preformed tubes have cross-sections that are different in shape from a cross-section of the corresponding flat pull wires.
6. The catheter assembly of claim 5 , wherein the steering mechanism comprises a single pull ring to which the at least two flat wires are secured.
7. The catheter assembly of claim 6 , wherein the single pull ring comprises a right circular cylinder having a slot for each of the at least two flat wires.
8. The catheter assembly of claim 7 , wherein the outer layer comprises a melt processing polymer, wherein the steering mechanism comprises a pull ring to which the at least two flat wires are secured, and wherein the pull ring comprises at least two flow holes, said outer layer being bonded to the pull ring such that the melt processing polymer occupies the at least two flow holes.
9. The catheter assembly of claim 2 , wherein the steering mechanism comprises at least two flat wires and at least two corresponding lumens through which the at least two flat wires may travel.
10. The catheter assembly of claim 9 , wherein each of the at least two flat wires has a cross-section that is rectangular, and wherein each of the at least two lumens has a cross-section selected from the group consisting of oval, round, and elliptical.
11. The catheter assembly of claim 9 , wherein each of the at least two flat wires has a cross-section that is measured X in one direction and at least 3X in a second direction, said second direction being substantially orthogonal to the first direction.
12. The catheter assembly of claim 9 , wherein each of the at least two flat wires is manufactured with a smooth surface to reduce friction between the flat wire and the corresponding lumen.
13. The catheter assembly of claim 1 , wherein the inner liner is polymeric and has a lumen diameter of at least about 6 French, and wherein the flat wires in the braided wire assembly are substantially rectangular in cross-section and have a width of at least about 0.007 inches and a depth of at least about 0.004 inches.
14. The catheter assembly of claim 13 , wherein the outer layer comprises a melt processing polymer, and wherein the melt-processing polymer occupies a plurality of voids of the wire mesh in the braided wire assembly.
15. The catheter assembly of claim 13 , wherein the inner liner has a lumen diameter of between about 7 French and about 32 French.
16. The catheter assembly of claim 13 , wherein the at least two flat wires have a ratio of width to thickness of at least about 2:1.
17. The catheter assembly of claim 13 , wherein the braided wire assembly has a braid density between about 5 PPI and about 100 PPI.
18. The catheter assembly of claim 1 , wherein the braided wire assembly is braided in a one-over, one-under pattern.
19. The catheter assembly of claim 1 , wherein the braided wire assembly comprises at least four flat wires braided in a two-over, two-under pattern.
20. A method of manufacturing a catheter, comprising the steps of:
providing a mandrel;
placing a lining material over the mandrel to form an inner liner;
providing at least one flat shaped wire;
placing a flexible liner over each of the at least one flat shaped wires to create at least one flat lumen;
placing a braided wire assembly over the inner liner and the at least one flat lumen, the braided wire assembly including at least two flat wires braided into a wire mesh;
covering the braided wire assembly with a melt processing polymer;
applying sufficient heat to the melt processing polymer to raise the temperature of the polymer above its melting point;
cooling the assembly; and
removing the mandrel, thereby forming a catheter.
21. The method of claim 20 , further comprising:
covering the melt processing polymer with shrink wrap tubing; and
removing the shrink wrap tubing after the melting process.
22. The method of claim 20 , further comprising:
covering the braided wire assembly with one or more flexible layers; and
covering the melt processing polymer with shrink wrap tubing.
23. The method of claim 20 , wherein the step of providing at least one flat shaped wire comprises providing at least one flat wire having a cross-section that is rectangular, and wherein the step of placing a flexible liner over each of the at least one flat shaped wires comprises placing a preformed flexible tube over each of the at least one flat shaped wires, wherein the preformed flexible tube has a cross-section selected from the group consisting of oval, round, and elliptical.
24. The method of claim 20 , wherein the inner liner is polymeric and has a lumen diameter of at least about 6 French, and wherein the flat wires in the braided wire assembly are substantially rectangular in cross-section and have a width of at least about 0.007 inches and a depth of at least about 0.004 inches.
25. The method of claim 20 , wherein the flat wires of the braided wire assembly are braided at a braid density of about 5 PPI to about 100 PPI.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/953,604 US20080091169A1 (en) | 2006-05-16 | 2007-12-10 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
JP2010538021A JP5769422B2 (en) | 2007-12-10 | 2008-11-12 | Steerable catheter using a flat pull wire and having a torque transfer layer made of braided flat wire |
PCT/US2008/083241 WO2009075989A1 (en) | 2007-12-10 | 2008-11-12 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
CN200880120096.8A CN101896217B (en) | 2007-12-10 | 2008-11-12 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
EP08859712A EP2190513A4 (en) | 2007-12-10 | 2008-11-12 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US12/861,555 US8734699B2 (en) | 2006-05-16 | 2010-08-23 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US14/284,026 US10099036B2 (en) | 2006-05-16 | 2014-05-21 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US16/152,127 US10912923B2 (en) | 2006-05-16 | 2018-10-04 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80037306P | 2006-05-16 | 2006-05-16 | |
US11/647,313 US20080234660A2 (en) | 2006-05-16 | 2006-12-29 | Steerable Catheter Using Flat Pull Wires and Method of Making Same |
US11/953,604 US20080091169A1 (en) | 2006-05-16 | 2007-12-10 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/647,313 Continuation-In-Part US20080234660A2 (en) | 2006-05-16 | 2006-12-29 | Steerable Catheter Using Flat Pull Wires and Method of Making Same |
US11/647,313 Continuation US20080234660A2 (en) | 2006-05-16 | 2006-12-29 | Steerable Catheter Using Flat Pull Wires and Method of Making Same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/861,555 Division US8734699B2 (en) | 2006-05-16 | 2010-08-23 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080091169A1 true US20080091169A1 (en) | 2008-04-17 |
Family
ID=40756177
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/953,604 Abandoned US20080091169A1 (en) | 2006-05-16 | 2007-12-10 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US12/861,555 Active 2029-08-02 US8734699B2 (en) | 2006-05-16 | 2010-08-23 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US14/284,026 Active 2028-11-11 US10099036B2 (en) | 2006-05-16 | 2014-05-21 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US16/152,127 Active 2027-06-13 US10912923B2 (en) | 2006-05-16 | 2018-10-04 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/861,555 Active 2029-08-02 US8734699B2 (en) | 2006-05-16 | 2010-08-23 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US14/284,026 Active 2028-11-11 US10099036B2 (en) | 2006-05-16 | 2014-05-21 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
US16/152,127 Active 2027-06-13 US10912923B2 (en) | 2006-05-16 | 2018-10-04 | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires |
Country Status (5)
Country | Link |
---|---|
US (4) | US20080091169A1 (en) |
EP (1) | EP2190513A4 (en) |
JP (1) | JP5769422B2 (en) |
CN (1) | CN101896217B (en) |
WO (1) | WO2009075989A1 (en) |
Cited By (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090165881A1 (en) * | 2007-12-31 | 2009-07-02 | Tegg Troy T | Catheter shaft and method of manufacture |
US20090260852A1 (en) * | 2008-02-29 | 2009-10-22 | Fort Wayne Metals Research Products Corporation | Alternating core composite wire |
US20090306651A1 (en) * | 2008-06-09 | 2009-12-10 | Clint Schneider | Catheter assembly with front-loaded tip |
US20090306655A1 (en) * | 2008-06-09 | 2009-12-10 | Stangenes Todd R | Catheter assembly with front-loaded tip and multi-contact connector |
US20110040308A1 (en) * | 2008-06-13 | 2011-02-17 | Ramiro Cabrera | Endoscopic Stitching Devices |
US20110077498A1 (en) * | 2009-09-29 | 2011-03-31 | Mcdaniel Benjamin D | Catheter with biased planar deflection |
WO2011056311A1 (en) * | 2009-11-09 | 2011-05-12 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
US20110218492A1 (en) * | 2005-02-14 | 2011-09-08 | Mcdaniel Benjamin D | Steerable catheter with in-plane deflection |
US20110238041A1 (en) * | 2010-03-24 | 2011-09-29 | Chestnut Medical Technologies, Inc. | Variable flexibility catheter |
WO2012071087A1 (en) | 2010-11-23 | 2012-05-31 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Medical devices having an electroanatomical system imaging element mounted thereon |
WO2013158403A1 (en) * | 2012-04-19 | 2013-10-24 | Medtronic Ablation Frontiers Llc | Catheter deflection anchor |
US20130340233A1 (en) * | 2008-12-03 | 2013-12-26 | C.R. Bard, Inc. | Retractable Catheter |
JP2014188211A (en) * | 2013-03-27 | 2014-10-06 | Sumitomo Bakelite Co Ltd | Medical instrument, and manufacturing method for medical instrument |
US20140336572A1 (en) * | 2013-05-07 | 2014-11-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Guiding Medical Devices and Associated Methods of Manufacturing |
WO2014182797A1 (en) * | 2013-05-07 | 2014-11-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Steerable medical device having multiple curve profiles |
US8968383B1 (en) | 2013-08-27 | 2015-03-03 | Covidien Lp | Delivery of medical devices |
US9044254B2 (en) | 2012-08-07 | 2015-06-02 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US20150306343A1 (en) * | 2014-04-25 | 2015-10-29 | Medtronic Ablation Frontiers Llc | Multi-lumen device with non collapsable minor lumen |
EP2937110A4 (en) * | 2012-12-18 | 2016-10-12 | Sumitomo Bakelite Co | Medical device |
US20160331933A1 (en) * | 2015-05-14 | 2016-11-17 | Medtronic Cryocath Lp | Dual deflection pull wire ring |
US9504398B2 (en) | 2002-08-24 | 2016-11-29 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Methods and apparatus for locating the fossa ovalis and performing transseptal puncture |
US9610122B2 (en) | 2013-03-29 | 2017-04-04 | Covidien Lp | Step-down coaxial microwave ablation applicators and methods for manufacturing same |
USRE46362E1 (en) | 2009-11-16 | 2017-04-11 | Covidien Lp | Twin sealing chamber hub |
US9615950B2 (en) | 2005-06-16 | 2017-04-11 | Angiomed Gmbh & Co. Medizintechnik Kg | Catheter device |
US9782186B2 (en) | 2013-08-27 | 2017-10-10 | Covidien Lp | Vascular intervention system |
US9848954B2 (en) | 2013-12-20 | 2017-12-26 | Corbin E. Barnett | Surgical system and related methods |
EP3332831A1 (en) * | 2016-12-07 | 2018-06-13 | Biosense Webster (Israel), Ltd. | Steerable guiding sheath with ring electrodes and related method of construction |
US10258763B2 (en) * | 2008-12-30 | 2019-04-16 | St. Jude Medical, Atrial Fibrillation, Inc. | Multi-lumen medical devices and methods of manufacturing same |
US10376396B2 (en) | 2017-01-19 | 2019-08-13 | Covidien Lp | Coupling units for medical device delivery systems |
US10376309B2 (en) | 2016-08-02 | 2019-08-13 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US10537452B2 (en) | 2012-02-23 | 2020-01-21 | Covidien Lp | Luminal stenting |
US10568738B2 (en) * | 2011-11-08 | 2020-02-25 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
US10624697B2 (en) | 2014-08-26 | 2020-04-21 | Covidien Lp | Microwave ablation system |
US10682232B2 (en) | 2013-03-15 | 2020-06-16 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
US10695046B2 (en) | 2005-07-05 | 2020-06-30 | Edwards Lifesciences Corporation | Tissue anchor and anchoring system |
US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
US10758709B2 (en) | 2016-05-26 | 2020-09-01 | Boston Scientific Scimed, Inc. | Articulating devices and methods |
US10786377B2 (en) | 2018-04-12 | 2020-09-29 | Covidien Lp | Medical device delivery |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799312B2 (en) | 2017-04-28 | 2020-10-13 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US10799675B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Cam controlled multi-direction steerable handles |
US10806575B2 (en) | 2008-08-22 | 2020-10-20 | Edwards Lifesciences Corporation | Heart valve treatment system |
US10813760B2 (en) | 2018-01-09 | 2020-10-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10813691B2 (en) | 2014-10-01 | 2020-10-27 | Covidien Lp | Miniaturized microwave ablation assembly |
US10813692B2 (en) | 2016-02-29 | 2020-10-27 | Covidien Lp | 90-degree interlocking geometry for introducer for facilitating deployment of microwave radiating catheter |
US10820998B2 (en) | 2017-05-10 | 2020-11-03 | Edwards Lifesciences Corporation | Valve repair device |
US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US10835714B2 (en) | 2016-03-21 | 2020-11-17 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10842627B2 (en) | 2017-04-18 | 2020-11-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10856987B2 (en) | 2009-05-07 | 2020-12-08 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
US10856986B2 (en) | 2008-12-22 | 2020-12-08 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
US10874514B2 (en) | 2017-04-18 | 2020-12-29 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10893939B2 (en) | 2012-10-23 | 2021-01-19 | Valtech Cardio, Ltd. | Controlled steering functionality for implant delivery tool |
US10905554B2 (en) | 2017-01-05 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve coaptation device |
US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US10918483B2 (en) | 2018-01-09 | 2021-02-16 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US10925735B2 (en) | 2018-01-09 | 2021-02-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
US10945844B2 (en) | 2018-10-10 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10959845B2 (en) | 2016-07-08 | 2021-03-30 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
US10959847B2 (en) | 2018-01-09 | 2021-03-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973638B2 (en) | 2016-07-07 | 2021-04-13 | Edwards Lifesciences Corporation | Device and method for treating vascular insufficiency |
US10973639B2 (en) | 2018-01-09 | 2021-04-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973637B2 (en) | 2013-12-26 | 2021-04-13 | Valtech Cardio, Ltd. | Implantation of flexible implant |
US11013598B2 (en) | 2018-01-09 | 2021-05-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11020227B2 (en) | 2015-04-30 | 2021-06-01 | Valtech Cardio, Ltd. | Annuloplasty technologies |
US11039925B2 (en) | 2018-01-09 | 2021-06-22 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11040174B2 (en) | 2017-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US11051940B2 (en) | 2017-09-07 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic spacer device for heart valve |
US11065001B2 (en) | 2013-10-23 | 2021-07-20 | Valtech Cardio, Ltd. | Anchor magazine |
US11065053B2 (en) | 2016-08-02 | 2021-07-20 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11071628B2 (en) | 2014-10-14 | 2021-07-27 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
US11071637B2 (en) | 2018-04-12 | 2021-07-27 | Covidien Lp | Medical device delivery |
US11076958B2 (en) | 2009-05-04 | 2021-08-03 | Valtech Cardio, Ltd. | Annuloplasty ring delivery catheters |
US11116634B2 (en) | 2008-12-22 | 2021-09-14 | Valtech Cardio Ltd. | Annuloplasty implants |
US11123209B2 (en) | 2018-04-12 | 2021-09-21 | Covidien Lp | Medical device delivery |
US11123191B2 (en) | 2018-07-12 | 2021-09-21 | Valtech Cardio Ltd. | Annuloplasty systems and locking tools therefor |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
US11141271B2 (en) | 2009-10-29 | 2021-10-12 | Valtech Cardio Ltd. | Tissue anchor for annuloplasty device |
US11185412B2 (en) | 2009-05-04 | 2021-11-30 | Valtech Cardio Ltd. | Deployment techniques for annuloplasty implants |
US11197759B2 (en) | 2011-11-04 | 2021-12-14 | Valtech Cardio Ltd. | Implant having multiple adjusting mechanisms |
US11197715B2 (en) | 2016-08-02 | 2021-12-14 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US11202709B2 (en) | 2009-02-17 | 2021-12-21 | Valtech Cardio Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US11207181B2 (en) | 2018-04-18 | 2021-12-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11259927B2 (en) | 2018-01-09 | 2022-03-01 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
CN114191685A (en) * | 2021-10-19 | 2022-03-18 | 深圳北芯医疗科技有限公司 | Catheter sheath |
WO2022060669A1 (en) * | 2020-09-15 | 2022-03-24 | Medtronic, Inc. | Deflectable delivery system for implant delivery |
US11298228B2 (en) | 2018-01-09 | 2022-04-12 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US20220126060A1 (en) * | 2020-10-23 | 2022-04-28 | Canon U.S.A., Inc. | Reinforced center lumen for steerable device |
US11344414B2 (en) | 2006-12-05 | 2022-05-31 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11344310B2 (en) | 2012-10-23 | 2022-05-31 | Valtech Cardio Ltd. | Percutaneous tissue anchor techniques |
US11350812B2 (en) * | 2018-08-30 | 2022-06-07 | Karl Storz Se & Co. Kg | Endoscope shaft having a layered structure, and method for producing same |
US11389297B2 (en) | 2018-04-12 | 2022-07-19 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
US11413174B2 (en) | 2019-06-26 | 2022-08-16 | Covidien Lp | Core assembly for medical device delivery systems |
US11413176B2 (en) | 2018-04-12 | 2022-08-16 | Covidien Lp | Medical device delivery |
US11497605B2 (en) | 2005-03-17 | 2022-11-15 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US11517718B2 (en) | 2016-11-07 | 2022-12-06 | Edwards Lifesciences Corporation | Apparatus for the introduction and manipulation of multiple telescoping catheters |
US11534583B2 (en) | 2013-03-14 | 2022-12-27 | Valtech Cardio Ltd. | Guidewire feeder |
US11547564B2 (en) | 2018-01-09 | 2023-01-10 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11559661B2 (en) * | 2010-12-30 | 2023-01-24 | St Jude Medical International Holding S.À R.L. | Method of fabricating an elongate medical device |
US11583400B2 (en) | 2012-12-06 | 2023-02-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guided advancement of a tool |
US11583396B2 (en) | 2009-12-04 | 2023-02-21 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US11602434B2 (en) | 2009-12-02 | 2023-03-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Systems and methods for tissue adjustment |
US11612485B2 (en) | 2018-01-09 | 2023-03-28 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11617652B2 (en) | 2009-10-29 | 2023-04-04 | Edwards Lifesciences Innovation (Israel) Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
US11666442B2 (en) | 2018-01-26 | 2023-06-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
US11690621B2 (en) | 2014-12-04 | 2023-07-04 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
US11766327B2 (en) | 2009-05-04 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Implantation of repair chords in the heart |
US11779463B2 (en) | 2018-01-24 | 2023-10-10 | Edwards Lifesciences Innovation (Israel) Ltd. | Contraction of an annuloplasty structure |
US11793642B2 (en) | 2015-05-14 | 2023-10-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11819411B2 (en) | 2019-10-29 | 2023-11-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
US11832784B2 (en) | 2017-11-02 | 2023-12-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant-cinching devices and systems |
US11839544B2 (en) | 2019-02-14 | 2023-12-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11944558B2 (en) | 2021-08-05 | 2024-04-02 | Covidien Lp | Medical device delivery devices, systems, and methods |
US11951263B2 (en) | 2020-10-08 | 2024-04-09 | Edwards Lifesciences Corporation | Multi-direction steerable handles |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008045877A2 (en) * | 2006-10-10 | 2008-04-17 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Electrode tip and ablation system |
US10660690B2 (en) | 2007-12-28 | 2020-05-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for measurement of an impedance using a catheter such as an ablation catheter |
US8684962B2 (en) | 2008-03-27 | 2014-04-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter device cartridge |
US8343096B2 (en) | 2008-03-27 | 2013-01-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter system |
US8317744B2 (en) | 2008-03-27 | 2012-11-27 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter manipulator assembly |
US9241768B2 (en) | 2008-03-27 | 2016-01-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Intelligent input device controller for a robotic catheter system |
US9161817B2 (en) | 2008-03-27 | 2015-10-20 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter system |
US8641664B2 (en) | 2008-03-27 | 2014-02-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter system with dynamic response |
US8641663B2 (en) | 2008-03-27 | 2014-02-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic catheter system input device |
US9339331B2 (en) | 2008-12-29 | 2016-05-17 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Non-contact electrode basket catheters with irrigation |
US20100274088A1 (en) * | 2009-04-23 | 2010-10-28 | Carl Frederic West | Flexible Medical Instrument |
US9330497B2 (en) | 2011-08-12 | 2016-05-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | User interface devices for electrophysiology lab diagnostic and therapeutic equipment |
US9439736B2 (en) | 2009-07-22 | 2016-09-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for controlling a remote medical device guidance system in three-dimensions using gestures |
US9888973B2 (en) | 2010-03-31 | 2018-02-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Intuitive user interface control for remote catheter navigation and 3D mapping and visualization systems |
US8906013B2 (en) | 2010-04-09 | 2014-12-09 | Endosense Sa | Control handle for a contact force ablation catheter |
US9918787B2 (en) | 2010-05-05 | 2018-03-20 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Monitoring, managing and/or protecting system and method for non-targeted tissue |
JP2013198633A (en) * | 2012-03-26 | 2013-10-03 | Sumitomo Bakelite Co Ltd | Medical instrument, and method for manufacturing medical instrument |
US9433752B2 (en) * | 2012-11-14 | 2016-09-06 | Biosense Webster (Israel) Ltd. | Catheter with flat beam deflection in tip |
JP6149431B2 (en) * | 2013-03-08 | 2017-06-21 | 住友ベークライト株式会社 | MEDICAL DEVICE, CATHETER AND METHOD FOR PRODUCING MEDICAL DEVICE |
JP6089864B2 (en) * | 2013-03-27 | 2017-03-08 | 住友ベークライト株式会社 | Medical device and method for manufacturing medical device |
JP6205785B2 (en) * | 2013-03-28 | 2017-10-04 | 住友ベークライト株式会社 | Medical equipment |
JP6089876B2 (en) * | 2013-03-28 | 2017-03-08 | 住友ベークライト株式会社 | Medical equipment |
US10602947B2 (en) * | 2013-04-11 | 2020-03-31 | Biosense Webster (Israel), Ltd. | High density electrode structure |
CA2915932C (en) | 2013-05-19 | 2023-10-17 | Cordis Corporation | Large lumen guide catheter |
US10835183B2 (en) | 2013-07-01 | 2020-11-17 | Zurich Medical Corporation | Apparatus and method for intravascular measurements |
WO2015003024A2 (en) | 2013-07-01 | 2015-01-08 | Zurich Medical, Inc. | Apparatus and method for intravascular measurements |
CN105682725A (en) * | 2013-08-23 | 2016-06-15 | 波士顿科学国际有限公司 | Catheters and catheter shafts |
EP3082930B1 (en) * | 2013-12-20 | 2019-07-17 | Boston Scientific Scimed, Inc. | Integrated catheter system |
JP5682719B1 (en) * | 2014-02-27 | 2015-03-11 | 住友ベークライト株式会社 | CATHETER AND METHOD FOR PRODUCING CATHETER |
US9868242B2 (en) | 2014-04-25 | 2018-01-16 | Medtronic Ablation Frontiers Llc | Methods of manufacturing a multi-lumen device |
US9505159B2 (en) | 2014-04-25 | 2016-11-29 | Medtronic Ablation Frontiers Llc | Methods of dimensionally stabilizing a lumen of a multi-lumen device during manufacture |
US10118022B2 (en) | 2014-06-05 | 2018-11-06 | St. Jude Medical, Cardiology Division, Inc. | Deflectable catheter shaft section |
US9844645B2 (en) | 2014-06-17 | 2017-12-19 | St. Jude Medical, Cardiology Division, Inc. | Triple coil catheter support |
US10602983B2 (en) | 2015-05-08 | 2020-03-31 | St. Jude Medical International Holding S.À R.L. | Integrated sensors for medical devices and method of making integrated sensors for medical devices |
JP2018532532A (en) | 2015-10-14 | 2018-11-08 | スリー リバーズ メディカル インク.Three Rivers Medical Inc. | Mechanical embolic delivery device and method |
US10799672B2 (en) | 2015-10-16 | 2020-10-13 | Covidien Lp | Catheter body structural support member including a polymer hypotube |
JP6445742B1 (en) | 2015-10-21 | 2018-12-26 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | High density electrode mapping catheter |
JP6137380B2 (en) * | 2016-04-26 | 2017-05-31 | 住友ベークライト株式会社 | Medical device manufacturing method |
US10987490B2 (en) | 2016-06-20 | 2021-04-27 | St. Jude Medical, Cardiology Division, Inc. | Multi-planar steerable medical shafts |
WO2018011627A2 (en) | 2016-07-13 | 2018-01-18 | NeuVT Limited | High flexibility, kink resistant catheter shaft |
US10531787B2 (en) | 2016-07-28 | 2020-01-14 | Cook Medical Technologies Llc | Steerable multilumen catheter shaft |
JP6319390B2 (en) * | 2016-09-14 | 2018-05-09 | 住友ベークライト株式会社 | Medical device and method for manufacturing medical device |
US11786705B2 (en) | 2016-10-24 | 2023-10-17 | St. Jude Medical, Cardiology Division, Inc. | Catheter insertion devices |
US11890427B2 (en) | 2017-01-03 | 2024-02-06 | St. Jude Medical, Cardiology Division, Inc. | Medical device with non-metallic reinforcing layer |
US10786651B2 (en) | 2017-03-07 | 2020-09-29 | Talon Medical, LLC | Steerable guide catheter |
WO2018195162A1 (en) | 2017-04-18 | 2018-10-25 | St. Jude Medical, Cardiology Division, Inc. | Torqueable steerable sheaths |
US11647935B2 (en) | 2017-07-24 | 2023-05-16 | St. Jude Medical, Cardiology Division, Inc. | Masked ring electrodes |
US20200367964A1 (en) | 2017-08-18 | 2020-11-26 | St. Jude Medical, Cardiology Division, Inc. | Medical catheters, systems including medical catheters, and methods of positioning medical catheters |
US20210121663A1 (en) | 2017-09-14 | 2021-04-29 | St. Jude Medical, Cardiology Division, Inc. | Torqueable steerable sheaths |
CN107550602A (en) * | 2017-09-28 | 2018-01-09 | 沛嘉医疗科技(苏州)有限公司 | One kind is through conduit aorta petal induction system and its application method |
EP3668581B1 (en) | 2017-11-28 | 2022-09-21 | St. Jude Medical, Cardiology Division, Inc. | Lumen management catheter |
EP3925638A1 (en) | 2017-12-15 | 2021-12-22 | Perfuze Limited | Improved catheters and devices and systems incorporating such catheters |
WO2019171095A1 (en) * | 2018-03-05 | 2019-09-12 | Medinol Ltd. | Catheter system with reinforced guidewire shaft and method of manufacture |
JP6792587B2 (en) * | 2018-03-26 | 2020-11-25 | 住友ベークライト株式会社 | Medical devices and manufacturing methods for medical devices |
WO2020039392A2 (en) | 2018-08-23 | 2020-02-27 | St. Jude Medical, Cardiology Division, Inc. | Curved high density electrode mapping catheter |
JP7329551B2 (en) * | 2018-09-11 | 2023-08-18 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | Single intravascular catheter shaft |
US11918762B2 (en) | 2018-10-03 | 2024-03-05 | St. Jude Medical, Cardiology Division, Inc. | Reduced actuation force electrophysiology catheter handle |
EP3873350A4 (en) * | 2018-10-29 | 2022-07-27 | Canon U.S.A., Inc. | Support structure for medical apparatus and method of manufacturing same |
US11666464B2 (en) | 2019-01-28 | 2023-06-06 | Tensor Flow Ventures Llc | Magnetic stent and stent delivery |
US10792469B1 (en) | 2019-08-14 | 2020-10-06 | Vasoinnovations Inc. | Devices, systems, and methods for delivering catheters or other medical devices to locations within a patients body |
US10828470B1 (en) | 2019-08-14 | 2020-11-10 | Vasoinnovations Inc. | Apparatus and method for advancing catheters or other medical devices through a lumen |
US10821267B1 (en) | 2019-08-14 | 2020-11-03 | Vasoinnovations Inc. | Apparatus and method for advancing catheters or other medical devices through a lumen |
US20210220626A1 (en) | 2019-08-14 | 2021-07-22 | Vasoinnovations, Inc. | Apparatus and method for advancing catheters or other medical devices through a lumen |
US10773059B1 (en) | 2019-08-14 | 2020-09-15 | Vasoinnovations, Inc. | Apparatus and method for advancing catheters or other medical devices through a lumen |
US11471650B2 (en) | 2019-09-20 | 2022-10-18 | Biosense Webster (Israel) Ltd. | Mechanism for manipulating a puller wire |
US20220386851A1 (en) * | 2019-11-13 | 2022-12-08 | Scivita Medical Technology Co., Ltd. | Endoscope structure |
CA3183162A1 (en) | 2020-06-19 | 2021-12-23 | Jake Anthony Sganga | Systems and methods for guidance of intraluminal devices within the vasculature |
WO2023278789A1 (en) | 2021-07-01 | 2023-01-05 | Remedy Robotics, Inc. | Vision-based position and orientation determination for endovascular tools |
US11707332B2 (en) | 2021-07-01 | 2023-07-25 | Remedy Robotics, Inc. | Image space control for endovascular tools |
CN116407348A (en) * | 2021-12-31 | 2023-07-11 | 杭州德晋医疗科技有限公司 | Adjustable curved sheath tube and medical instrument conveying system |
CN116035767A (en) * | 2022-09-08 | 2023-05-02 | 苏州汇禾医疗科技有限公司 | Medical instrument conveying sheath tube and conveying system for human body |
CN115430006B (en) * | 2022-10-08 | 2023-12-08 | 苏州汇禾医疗科技有限公司 | Medical delivery member and preparation method thereof |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4306029A (en) * | 1980-04-30 | 1981-12-15 | Baxter Travenol Laboratories, Inc. | Urine storage containers with urease |
US4425919A (en) * | 1981-07-27 | 1984-01-17 | Raychem Corporation | Torque transmitting catheter apparatus |
US5238005A (en) * | 1991-11-18 | 1993-08-24 | Intelliwire, Inc. | Steerable catheter guidewire |
US5487757A (en) * | 1993-07-20 | 1996-01-30 | Medtronic Cardiorhythm | Multicurve deflectable catheter |
US5906605A (en) * | 1997-01-10 | 1999-05-25 | Cardiac Pathways Corporation | Torquable guiding catheter for basket deployment and method |
US6143013A (en) * | 1995-04-28 | 2000-11-07 | Target Therapeutics, Inc. | High performance braided catheter |
US20020077590A1 (en) * | 1999-03-03 | 2002-06-20 | Cordis Webster, Inc. | Deflectable catheter |
US6450948B1 (en) * | 1999-11-02 | 2002-09-17 | Vista Medical Technologies, Inc. | Deflecting tip for surgical cannula |
US20020177772A1 (en) * | 1997-03-13 | 2002-11-28 | Altman Peter A. | Drug delivery catheters that attach to tissue and methods for their use |
US6582536B2 (en) * | 2000-04-24 | 2003-06-24 | Biotran Corporation Inc. | Process for producing steerable sheath catheters |
US20040122360A1 (en) * | 2002-12-23 | 2004-06-24 | Waldhauser Steven L. | Steerable catheter |
US20040181208A1 (en) * | 2003-03-14 | 2004-09-16 | Poole Matthew S. | Catheter reinforced with high yield strength wire |
US20050008467A1 (en) * | 2003-07-11 | 2005-01-13 | Rich Huang | Load port transfer device |
US20050107737A1 (en) * | 2003-11-19 | 2005-05-19 | Mcdaniel Benjamin D. | Bidirectional steerable catheter with slidable mated puller wires |
US20070005008A1 (en) * | 2005-06-09 | 2007-01-04 | Brian Honebrink | Push-pull wire anchor |
US20070270679A1 (en) * | 2006-05-17 | 2007-11-22 | Duy Nguyen | Deflectable variable radius catheters |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5886129A (en) * | 1981-11-17 | 1983-05-23 | 旭光学工業株式会社 | Flexible tube of endoscope and production thereof |
US4686963A (en) * | 1986-03-05 | 1987-08-18 | Circon Corporation | Torsion resistant vertebrated probe of simple construction |
US5125895A (en) | 1986-07-22 | 1992-06-30 | Medtronic Versaflex, Inc. | Steerable catheter |
US5125896A (en) | 1990-10-10 | 1992-06-30 | C. R. Bard, Inc. | Steerable electrode catheter |
US5281217A (en) | 1992-04-13 | 1994-01-25 | Ep Technologies, Inc. | Steerable antenna systems for cardiac ablation that minimize tissue damage and blood coagulation due to conductive heating patterns |
US5472017A (en) * | 1992-11-17 | 1995-12-05 | Life Medical Technologies, Inc. | Deflectable catheter |
US5954651A (en) * | 1993-08-18 | 1999-09-21 | Scimed Life Systems, Inc. | Catheter having a high tensile strength braid wire constraint |
JPH07178176A (en) * | 1993-12-24 | 1995-07-18 | Terumo Corp | Catheter |
US5395329A (en) | 1994-01-19 | 1995-03-07 | Daig Corporation | Control handle for steerable catheter |
US5395328A (en) | 1994-01-19 | 1995-03-07 | Daig Corporation | Steerable catheter tip having an X-shaped lumen |
US5599305A (en) | 1994-10-24 | 1997-02-04 | Cardiovascular Concepts, Inc. | Large-diameter introducer sheath having hemostasis valve and removable steering mechanism |
US5676653A (en) | 1995-06-27 | 1997-10-14 | Arrow International Investment Corp. | Kink-resistant steerable catheter assembly |
US6023638A (en) | 1995-07-28 | 2000-02-08 | Scimed Life Systems, Inc. | System and method for conducting electrophysiological testing using high-voltage energy pulses to stun tissue |
US5782828A (en) | 1996-12-11 | 1998-07-21 | Irvine Biomedical, Inc. | Ablation catheter with multiple flexible curves |
US5897554A (en) | 1997-03-01 | 1999-04-27 | Irvine Biomedical, Inc. | Steerable catheter having a loop electrode |
US5876340A (en) | 1997-04-17 | 1999-03-02 | Irvine Biomedical, Inc. | Ablation apparatus with ultrasonic imaging capabilities |
US5941845A (en) | 1997-08-05 | 1999-08-24 | Irvine Biomedical, Inc. | Catheter having multiple-needle electrode and methods thereof |
US5893884A (en) | 1997-05-19 | 1999-04-13 | Irvine Biomedical, Inc. | Catheter system having rollable electrode means |
US5843152A (en) | 1997-06-02 | 1998-12-01 | Irvine Biomedical, Inc. | Catheter system having a ball electrode |
US5861024A (en) | 1997-06-20 | 1999-01-19 | Cardiac Assist Devices, Inc | Electrophysiology catheter and remote actuator therefor |
US5891138A (en) | 1997-08-11 | 1999-04-06 | Irvine Biomedical, Inc. | Catheter system having parallel electrodes |
US6233477B1 (en) | 1997-10-20 | 2001-05-15 | Irvine Biomedical, Inc. | Catheter system having controllable ultrasound locating means |
US6251092B1 (en) | 1997-12-30 | 2001-06-26 | Medtronic, Inc. | Deflectable guiding catheter |
US6308090B1 (en) | 1998-03-09 | 2001-10-23 | Irvine Biomedical, Inc. | Devices and methods for coronary sinus mapping |
US5951471A (en) | 1998-03-09 | 1999-09-14 | Irvine Biomedical, Inc. | Catheter-based coronary sinus mapping and ablation |
US6241727B1 (en) | 1998-05-27 | 2001-06-05 | Irvine Biomedical, Inc. | Ablation catheter system having circular lesion capabilities |
US6029091A (en) | 1998-07-09 | 2000-02-22 | Irvine Biomedical, Inc. | Catheter system having lattice electrodes |
US7972323B1 (en) | 1998-10-02 | 2011-07-05 | Boston Scientific Scimed, Inc. | Steerable device for introducing diagnostic and therapeutic apparatus into the body |
US6544215B1 (en) * | 1998-10-02 | 2003-04-08 | Scimed Life Systems, Inc. | Steerable device for introducing diagnostic and therapeutic apparatus into the body |
US6033403A (en) | 1998-10-08 | 2000-03-07 | Irvine Biomedical, Inc. | Long electrode catheter system and methods thereof |
JP2001178826A (en) | 1999-12-27 | 2001-07-03 | Hirakawa Hewtech Corp | Tube for catheter |
US6482221B1 (en) | 2000-08-21 | 2002-11-19 | Counter Clockwise, Inc. | Manipulatable delivery catheter for occlusive devices (II) |
US6942661B2 (en) | 2000-08-30 | 2005-09-13 | Boston Scientific Scimed, Inc. | Fluid cooled apparatus for supporting diagnostic and therapeutic elements in contact with tissue |
US6666862B2 (en) | 2001-03-01 | 2003-12-23 | Cardiac Pacemakers, Inc. | Radio frequency ablation system and method linking energy delivery with fluid flow |
US7819866B2 (en) * | 2003-01-21 | 2010-10-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Ablation catheter and electrode |
US7591813B2 (en) * | 2003-10-01 | 2009-09-22 | Micrus Endovascular Corporation | Long nose manipulatable catheter |
US8414524B2 (en) * | 2003-10-01 | 2013-04-09 | Micrus Endovascular Corporation | Long nose manipulatable catheter |
US7641647B2 (en) | 2003-12-29 | 2010-01-05 | Boston Scientific Scimed, Inc. | Medical device with modified marker band |
US7331959B2 (en) | 2004-05-27 | 2008-02-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter electrode and rail system for cardiac ablation |
US20080234660A2 (en) * | 2006-05-16 | 2008-09-25 | Sarah Cumming | Steerable Catheter Using Flat Pull Wires and Method of Making Same |
-
2007
- 2007-12-10 US US11/953,604 patent/US20080091169A1/en not_active Abandoned
-
2008
- 2008-11-12 JP JP2010538021A patent/JP5769422B2/en not_active Expired - Fee Related
- 2008-11-12 WO PCT/US2008/083241 patent/WO2009075989A1/en active Application Filing
- 2008-11-12 CN CN200880120096.8A patent/CN101896217B/en not_active Expired - Fee Related
- 2008-11-12 EP EP08859712A patent/EP2190513A4/en not_active Withdrawn
-
2010
- 2010-08-23 US US12/861,555 patent/US8734699B2/en active Active
-
2014
- 2014-05-21 US US14/284,026 patent/US10099036B2/en active Active
-
2018
- 2018-10-04 US US16/152,127 patent/US10912923B2/en active Active
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4306029A (en) * | 1980-04-30 | 1981-12-15 | Baxter Travenol Laboratories, Inc. | Urine storage containers with urease |
US4425919A (en) * | 1981-07-27 | 1984-01-17 | Raychem Corporation | Torque transmitting catheter apparatus |
US5238005A (en) * | 1991-11-18 | 1993-08-24 | Intelliwire, Inc. | Steerable catheter guidewire |
US5487757A (en) * | 1993-07-20 | 1996-01-30 | Medtronic Cardiorhythm | Multicurve deflectable catheter |
US6143013A (en) * | 1995-04-28 | 2000-11-07 | Target Therapeutics, Inc. | High performance braided catheter |
US5906605A (en) * | 1997-01-10 | 1999-05-25 | Cardiac Pathways Corporation | Torquable guiding catheter for basket deployment and method |
US20020177772A1 (en) * | 1997-03-13 | 2002-11-28 | Altman Peter A. | Drug delivery catheters that attach to tissue and methods for their use |
US20020077590A1 (en) * | 1999-03-03 | 2002-06-20 | Cordis Webster, Inc. | Deflectable catheter |
US6450948B1 (en) * | 1999-11-02 | 2002-09-17 | Vista Medical Technologies, Inc. | Deflecting tip for surgical cannula |
US6582536B2 (en) * | 2000-04-24 | 2003-06-24 | Biotran Corporation Inc. | Process for producing steerable sheath catheters |
US20040122360A1 (en) * | 2002-12-23 | 2004-06-24 | Waldhauser Steven L. | Steerable catheter |
US20040181208A1 (en) * | 2003-03-14 | 2004-09-16 | Poole Matthew S. | Catheter reinforced with high yield strength wire |
US20050008467A1 (en) * | 2003-07-11 | 2005-01-13 | Rich Huang | Load port transfer device |
US20050107737A1 (en) * | 2003-11-19 | 2005-05-19 | Mcdaniel Benjamin D. | Bidirectional steerable catheter with slidable mated puller wires |
US20070005008A1 (en) * | 2005-06-09 | 2007-01-04 | Brian Honebrink | Push-pull wire anchor |
US20070270679A1 (en) * | 2006-05-17 | 2007-11-22 | Duy Nguyen | Deflectable variable radius catheters |
Cited By (238)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9504398B2 (en) | 2002-08-24 | 2016-11-29 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Methods and apparatus for locating the fossa ovalis and performing transseptal puncture |
US20110218492A1 (en) * | 2005-02-14 | 2011-09-08 | Mcdaniel Benjamin D | Steerable catheter with in-plane deflection |
US8882705B2 (en) | 2005-02-14 | 2014-11-11 | Biosense Webster, Inc. | Steerable catheter with in-plane deflection |
US11497605B2 (en) | 2005-03-17 | 2022-11-15 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US10596020B2 (en) | 2005-06-16 | 2020-03-24 | Angiomed Gmbh & Co. Medizintechnik Kg | Catheter device |
US9615950B2 (en) | 2005-06-16 | 2017-04-11 | Angiomed Gmbh & Co. Medizintechnik Kg | Catheter device |
US10695046B2 (en) | 2005-07-05 | 2020-06-30 | Edwards Lifesciences Corporation | Tissue anchor and anchoring system |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11344414B2 (en) | 2006-12-05 | 2022-05-31 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US10485948B2 (en) | 2007-12-31 | 2019-11-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter shaft and method of manufacture |
US11376397B2 (en) | 2007-12-31 | 2022-07-05 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter shaft and method of manufacture |
US20090165881A1 (en) * | 2007-12-31 | 2009-07-02 | Tegg Troy T | Catheter shaft and method of manufacture |
US8684999B2 (en) * | 2007-12-31 | 2014-04-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter shaft and method of manufacture |
US7989703B2 (en) | 2008-02-29 | 2011-08-02 | Fort Wayne Metals Research Products Corporation | Alternating core composite wire |
US20090260852A1 (en) * | 2008-02-29 | 2009-10-22 | Fort Wayne Metals Research Products Corporation | Alternating core composite wire |
US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
US20090306655A1 (en) * | 2008-06-09 | 2009-12-10 | Stangenes Todd R | Catheter assembly with front-loaded tip and multi-contact connector |
US8206385B2 (en) | 2008-06-09 | 2012-06-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter assembly with front-loaded tip and multi-contact connector |
WO2009152151A1 (en) * | 2008-06-09 | 2009-12-17 | St. Jude Medical | Catheter assembly with front-loaded tip and multi-contact connector |
US20090306651A1 (en) * | 2008-06-09 | 2009-12-10 | Clint Schneider | Catheter assembly with front-loaded tip |
US20110040308A1 (en) * | 2008-06-13 | 2011-02-17 | Ramiro Cabrera | Endoscopic Stitching Devices |
US10945722B2 (en) | 2008-06-13 | 2021-03-16 | Covidien Lp | Endoscopic stitching devices |
US11849936B2 (en) | 2008-06-13 | 2023-12-26 | Covidien Lp | Endoscopic stitching devices |
US10413289B2 (en) * | 2008-06-13 | 2019-09-17 | Covidien Lp | Endoscopic stitching devices |
US10806575B2 (en) | 2008-08-22 | 2020-10-20 | Edwards Lifesciences Corporation | Heart valve treatment system |
US20130340233A1 (en) * | 2008-12-03 | 2013-12-26 | C.R. Bard, Inc. | Retractable Catheter |
US11116634B2 (en) | 2008-12-22 | 2021-09-14 | Valtech Cardio Ltd. | Annuloplasty implants |
US10856986B2 (en) | 2008-12-22 | 2020-12-08 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
US10258763B2 (en) * | 2008-12-30 | 2019-04-16 | St. Jude Medical, Atrial Fibrillation, Inc. | Multi-lumen medical devices and methods of manufacturing same |
US11596765B2 (en) | 2008-12-30 | 2023-03-07 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Multi-lumen medical devices and methods of manufacturing same |
US11202709B2 (en) | 2009-02-17 | 2021-12-21 | Valtech Cardio Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US11076958B2 (en) | 2009-05-04 | 2021-08-03 | Valtech Cardio, Ltd. | Annuloplasty ring delivery catheters |
US11766327B2 (en) | 2009-05-04 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Implantation of repair chords in the heart |
US11185412B2 (en) | 2009-05-04 | 2021-11-30 | Valtech Cardio Ltd. | Deployment techniques for annuloplasty implants |
US11844665B2 (en) | 2009-05-04 | 2023-12-19 | Edwards Lifesciences Innovation (Israel) Ltd. | Deployment techniques for annuloplasty structure |
US11723774B2 (en) | 2009-05-07 | 2023-08-15 | Edwards Lifesciences Innovation (Israel) Ltd. | Multiple anchor delivery tool |
US10856987B2 (en) | 2009-05-07 | 2020-12-08 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
US9101733B2 (en) * | 2009-09-29 | 2015-08-11 | Biosense Webster, Inc. | Catheter with biased planar deflection |
US20110077498A1 (en) * | 2009-09-29 | 2011-03-31 | Mcdaniel Benjamin D | Catheter with biased planar deflection |
US11617652B2 (en) | 2009-10-29 | 2023-04-04 | Edwards Lifesciences Innovation (Israel) Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US11141271B2 (en) | 2009-10-29 | 2021-10-12 | Valtech Cardio Ltd. | Tissue anchor for annuloplasty device |
US10675444B2 (en) | 2009-11-09 | 2020-06-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
US9486612B2 (en) | 2009-11-09 | 2016-11-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
US8376991B2 (en) | 2009-11-09 | 2013-02-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
WO2011056311A1 (en) * | 2009-11-09 | 2011-05-12 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
US20110112476A1 (en) * | 2009-11-09 | 2011-05-12 | Kauphusman James V | Device for reducing axial shortening of catheter or sheath due to repeated deflection |
USRE46362E1 (en) | 2009-11-16 | 2017-04-11 | Covidien Lp | Twin sealing chamber hub |
US11602434B2 (en) | 2009-12-02 | 2023-03-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Systems and methods for tissue adjustment |
US11583396B2 (en) | 2009-12-04 | 2023-02-21 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US11660185B2 (en) | 2009-12-04 | 2023-05-30 | Edwards Lifesciences Corporation | Ventricular anchors for valve repair and replacement devices |
US11911264B2 (en) | 2009-12-04 | 2024-02-27 | Edwards Lifesciences Corporation | Valve repair and replacement devices |
US20110238041A1 (en) * | 2010-03-24 | 2011-09-29 | Chestnut Medical Technologies, Inc. | Variable flexibility catheter |
CN103298392A (en) * | 2010-11-23 | 2013-09-11 | 圣犹达医疗用品电生理部门有限公司 | Medical devices having an electroanatomical system imaging element mounted thereon |
WO2012071087A1 (en) | 2010-11-23 | 2012-05-31 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Medical devices having an electroanatomical system imaging element mounted thereon |
EP2613686A4 (en) * | 2010-11-23 | 2014-07-02 | St Jude Medical Atrial Fibrill | Medical devices having an electroanatomical system imaging element mounted thereon |
EP2613686A1 (en) * | 2010-11-23 | 2013-07-17 | St. Jude Medical Atrial Fibrillation Division Inc. | Medical devices having an electroanatomical system imaging element mounted thereon |
US11559661B2 (en) * | 2010-12-30 | 2023-01-24 | St Jude Medical International Holding S.À R.L. | Method of fabricating an elongate medical device |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US11197759B2 (en) | 2011-11-04 | 2021-12-14 | Valtech Cardio Ltd. | Implant having multiple adjusting mechanisms |
US10568738B2 (en) * | 2011-11-08 | 2020-02-25 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
US11857415B2 (en) | 2011-11-08 | 2024-01-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
US11259946B2 (en) | 2012-02-23 | 2022-03-01 | Covidien Lp | Luminal stenting |
US10537452B2 (en) | 2012-02-23 | 2020-01-21 | Covidien Lp | Luminal stenting |
WO2013158403A1 (en) * | 2012-04-19 | 2013-10-24 | Medtronic Ablation Frontiers Llc | Catheter deflection anchor |
US9044248B2 (en) | 2012-04-19 | 2015-06-02 | Medtronic Ablation Frontiers Llc | Catheter deflection anchor |
US8702647B2 (en) | 2012-04-19 | 2014-04-22 | Medtronic Ablation Frontiers Llc | Catheter deflection anchor |
US9993296B2 (en) | 2012-08-07 | 2018-06-12 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US9044254B2 (en) | 2012-08-07 | 2015-06-02 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US9247992B2 (en) | 2012-08-07 | 2016-02-02 | Covidien, LP | Microwave ablation catheter and method of utilizing the same |
US9247993B2 (en) | 2012-08-07 | 2016-02-02 | Covidien, LP | Microwave ablation catheter and method of utilizing the same |
US9259269B2 (en) | 2012-08-07 | 2016-02-16 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US9370398B2 (en) | 2012-08-07 | 2016-06-21 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US11678934B2 (en) | 2012-08-07 | 2023-06-20 | Covidien Lp | Microwave ablation system |
US9993295B2 (en) | 2012-08-07 | 2018-06-12 | Covidien Lp | Microwave ablation catheter and method of utilizing the same |
US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
US11344310B2 (en) | 2012-10-23 | 2022-05-31 | Valtech Cardio Ltd. | Percutaneous tissue anchor techniques |
US11890190B2 (en) | 2012-10-23 | 2024-02-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Location indication system for implant-delivery tool |
US10893939B2 (en) | 2012-10-23 | 2021-01-19 | Valtech Cardio, Ltd. | Controlled steering functionality for implant delivery tool |
US11583400B2 (en) | 2012-12-06 | 2023-02-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guided advancement of a tool |
EP2937110A4 (en) * | 2012-12-18 | 2016-10-12 | Sumitomo Bakelite Co | Medical device |
US11793505B2 (en) | 2013-02-26 | 2023-10-24 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US11534583B2 (en) | 2013-03-14 | 2022-12-27 | Valtech Cardio Ltd. | Guidewire feeder |
US11890194B2 (en) | 2013-03-15 | 2024-02-06 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
US10682232B2 (en) | 2013-03-15 | 2020-06-16 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
JP2014188211A (en) * | 2013-03-27 | 2014-10-06 | Sumitomo Bakelite Co Ltd | Medical instrument, and manufacturing method for medical instrument |
US9610122B2 (en) | 2013-03-29 | 2017-04-04 | Covidien Lp | Step-down coaxial microwave ablation applicators and methods for manufacturing same |
US9987087B2 (en) | 2013-03-29 | 2018-06-05 | Covidien Lp | Step-down coaxial microwave ablation applicators and methods for manufacturing same |
US11382692B2 (en) | 2013-03-29 | 2022-07-12 | Covidien Lp | Step-down coaxial microwave ablation applicators and methods for manufacturing same |
US10383688B2 (en) | 2013-03-29 | 2019-08-20 | Covidien Lp | Step-down coaxial microwave ablation applicators and methods for manufacturing same |
US20170296777A1 (en) * | 2013-05-07 | 2017-10-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Guiding Medical Devices and Associated Methods of Manufacturing |
US10625044B2 (en) * | 2013-05-07 | 2020-04-21 | St. Jude Medical, Atrial Fibrilation Division, Inc. | Guiding medical devices and associated methods of manufacturing |
WO2014182797A1 (en) * | 2013-05-07 | 2014-11-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Steerable medical device having multiple curve profiles |
US20140336572A1 (en) * | 2013-05-07 | 2014-11-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Guiding Medical Devices and Associated Methods of Manufacturing |
US9827126B2 (en) | 2013-08-27 | 2017-11-28 | Covidien Lp | Delivery of medical devices |
US8968383B1 (en) | 2013-08-27 | 2015-03-03 | Covidien Lp | Delivery of medical devices |
US11103374B2 (en) | 2013-08-27 | 2021-08-31 | Covidien Lp | Delivery of medical devices |
US9775733B2 (en) | 2013-08-27 | 2017-10-03 | Covidien Lp | Delivery of medical devices |
US11076972B2 (en) | 2013-08-27 | 2021-08-03 | Covidien Lp | Delivery of medical devices |
US9782186B2 (en) | 2013-08-27 | 2017-10-10 | Covidien Lp | Vascular intervention system |
US10265207B2 (en) | 2013-08-27 | 2019-04-23 | Covidien Lp | Delivery of medical devices |
US10695204B2 (en) | 2013-08-27 | 2020-06-30 | Covidien Lp | Delivery of medical devices |
US10092431B2 (en) | 2013-08-27 | 2018-10-09 | Covidien Lp | Delivery of medical devices |
US10045867B2 (en) | 2013-08-27 | 2018-08-14 | Covidien Lp | Delivery of medical devices |
US11744573B2 (en) | 2013-08-31 | 2023-09-05 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US11766263B2 (en) | 2013-10-23 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor magazine |
US11065001B2 (en) | 2013-10-23 | 2021-07-20 | Valtech Cardio, Ltd. | Anchor magazine |
US9848954B2 (en) | 2013-12-20 | 2017-12-26 | Corbin E. Barnett | Surgical system and related methods |
US10849701B2 (en) | 2013-12-20 | 2020-12-01 | Corbin Barnett | Surgical system and related methods |
US10973637B2 (en) | 2013-12-26 | 2021-04-13 | Valtech Cardio, Ltd. | Implantation of flexible implant |
US20150306343A1 (en) * | 2014-04-25 | 2015-10-29 | Medtronic Ablation Frontiers Llc | Multi-lumen device with non collapsable minor lumen |
US10076634B2 (en) * | 2014-04-25 | 2018-09-18 | Medtronic Ablation Frontiers Llc | Multi-lumen device with non collapsable minor lumen |
US10624697B2 (en) | 2014-08-26 | 2020-04-21 | Covidien Lp | Microwave ablation system |
US10813691B2 (en) | 2014-10-01 | 2020-10-27 | Covidien Lp | Miniaturized microwave ablation assembly |
US11839426B2 (en) | 2014-10-01 | 2023-12-12 | Covidien Lp | Miniaturized microwave ablation assembly |
US11071628B2 (en) | 2014-10-14 | 2021-07-27 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
US11690621B2 (en) | 2014-12-04 | 2023-07-04 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
US11020227B2 (en) | 2015-04-30 | 2021-06-01 | Valtech Cardio, Ltd. | Annuloplasty technologies |
US11793642B2 (en) | 2015-05-14 | 2023-10-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US20160331933A1 (en) * | 2015-05-14 | 2016-11-17 | Medtronic Cryocath Lp | Dual deflection pull wire ring |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
US11660192B2 (en) | 2015-12-30 | 2023-05-30 | Edwards Lifesciences Corporation | System and method for reshaping heart |
US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US11890193B2 (en) | 2015-12-30 | 2024-02-06 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US10813692B2 (en) | 2016-02-29 | 2020-10-27 | Covidien Lp | 90-degree interlocking geometry for introducer for facilitating deployment of microwave radiating catheter |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799675B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Cam controlled multi-direction steerable handles |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10835714B2 (en) | 2016-03-21 | 2020-11-17 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US10758709B2 (en) | 2016-05-26 | 2020-09-01 | Boston Scientific Scimed, Inc. | Articulating devices and methods |
US11540835B2 (en) | 2016-05-26 | 2023-01-03 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US11759610B2 (en) | 2016-05-26 | 2023-09-19 | Boston Scientific Scimed, Inc. | Articulating devices and methods |
US10973638B2 (en) | 2016-07-07 | 2021-04-13 | Edwards Lifesciences Corporation | Device and method for treating vascular insufficiency |
US10959845B2 (en) | 2016-07-08 | 2021-03-30 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
US10376309B2 (en) | 2016-08-02 | 2019-08-13 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US11065053B2 (en) | 2016-08-02 | 2021-07-20 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US11197715B2 (en) | 2016-08-02 | 2021-12-14 | Covidien Lp | Ablation cable assemblies and a method of manufacturing the same |
US11517718B2 (en) | 2016-11-07 | 2022-12-06 | Edwards Lifesciences Corporation | Apparatus for the introduction and manipulation of multiple telescoping catheters |
US11534078B2 (en) | 2016-12-07 | 2022-12-27 | Biosense Webster (Israel) Ltd. | Steerable guiding sheath with ring electrodes and related method of construction |
EP3332831A1 (en) * | 2016-12-07 | 2018-06-13 | Biosense Webster (Israel), Ltd. | Steerable guiding sheath with ring electrodes and related method of construction |
US10905554B2 (en) | 2017-01-05 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve coaptation device |
US10376396B2 (en) | 2017-01-19 | 2019-08-13 | Covidien Lp | Coupling units for medical device delivery systems |
US11833069B2 (en) | 2017-01-19 | 2023-12-05 | Covidien Lp | Coupling units for medical device delivery systems |
US10945867B2 (en) | 2017-01-19 | 2021-03-16 | Covidien Lp | Coupling units for medical device delivery systems |
US10925734B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11723772B2 (en) | 2017-04-18 | 2023-08-15 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11000373B2 (en) | 2017-04-18 | 2021-05-11 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10905552B2 (en) | 2017-04-18 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11160657B2 (en) | 2017-04-18 | 2021-11-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11602431B2 (en) | 2017-04-18 | 2023-03-14 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11179240B2 (en) | 2017-04-18 | 2021-11-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10888425B2 (en) | 2017-04-18 | 2021-01-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10874514B2 (en) | 2017-04-18 | 2020-12-29 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10905553B2 (en) | 2017-04-18 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10898327B2 (en) | 2017-04-18 | 2021-01-26 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11883611B2 (en) | 2017-04-18 | 2024-01-30 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US10918482B2 (en) | 2017-04-18 | 2021-02-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11013601B2 (en) | 2017-04-18 | 2021-05-25 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11224511B2 (en) | 2017-04-18 | 2022-01-18 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11234822B2 (en) | 2017-04-18 | 2022-02-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11850153B2 (en) | 2017-04-18 | 2023-12-26 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11096784B2 (en) | 2017-04-18 | 2021-08-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10869763B2 (en) | 2017-04-18 | 2020-12-22 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10925732B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10842627B2 (en) | 2017-04-18 | 2020-11-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11020229B2 (en) | 2017-04-18 | 2021-06-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10959848B2 (en) | 2017-04-18 | 2021-03-30 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10925733B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10932908B2 (en) | 2017-04-18 | 2021-03-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10952853B2 (en) | 2017-04-18 | 2021-03-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10940005B2 (en) | 2017-04-18 | 2021-03-09 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11058539B2 (en) | 2017-04-18 | 2021-07-13 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10945843B2 (en) | 2017-04-18 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US10849754B2 (en) | 2017-04-18 | 2020-12-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10799312B2 (en) | 2017-04-28 | 2020-10-13 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US11406468B2 (en) | 2017-04-28 | 2022-08-09 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US11166778B2 (en) | 2017-04-28 | 2021-11-09 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US10959846B2 (en) | 2017-05-10 | 2021-03-30 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10820998B2 (en) | 2017-05-10 | 2020-11-03 | Edwards Lifesciences Corporation | Valve repair device |
US11051940B2 (en) | 2017-09-07 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic spacer device for heart valve |
US11730598B2 (en) | 2017-09-07 | 2023-08-22 | Edwards Lifesciences Corporation | Prosthetic device for heart valve |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11110251B2 (en) | 2017-09-19 | 2021-09-07 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11040174B2 (en) | 2017-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11944762B2 (en) | 2017-09-19 | 2024-04-02 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11832784B2 (en) | 2017-11-02 | 2023-12-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant-cinching devices and systems |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
US10925735B2 (en) | 2018-01-09 | 2021-02-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10959847B2 (en) | 2018-01-09 | 2021-03-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11918469B2 (en) | 2018-01-09 | 2024-03-05 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11547564B2 (en) | 2018-01-09 | 2023-01-10 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11612485B2 (en) | 2018-01-09 | 2023-03-28 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11013598B2 (en) | 2018-01-09 | 2021-05-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11298228B2 (en) | 2018-01-09 | 2022-04-12 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11259927B2 (en) | 2018-01-09 | 2022-03-01 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973639B2 (en) | 2018-01-09 | 2021-04-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11039925B2 (en) | 2018-01-09 | 2021-06-22 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11850154B2 (en) | 2018-01-09 | 2023-12-26 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10813760B2 (en) | 2018-01-09 | 2020-10-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10918483B2 (en) | 2018-01-09 | 2021-02-16 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11779463B2 (en) | 2018-01-24 | 2023-10-10 | Edwards Lifesciences Innovation (Israel) Ltd. | Contraction of an annuloplasty structure |
US11666442B2 (en) | 2018-01-26 | 2023-06-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
US11648140B2 (en) | 2018-04-12 | 2023-05-16 | Covidien Lp | Medical device delivery |
US10786377B2 (en) | 2018-04-12 | 2020-09-29 | Covidien Lp | Medical device delivery |
US11389297B2 (en) | 2018-04-12 | 2022-07-19 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US11413176B2 (en) | 2018-04-12 | 2022-08-16 | Covidien Lp | Medical device delivery |
US11071637B2 (en) | 2018-04-12 | 2021-07-27 | Covidien Lp | Medical device delivery |
US11123209B2 (en) | 2018-04-12 | 2021-09-21 | Covidien Lp | Medical device delivery |
US11207181B2 (en) | 2018-04-18 | 2021-12-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11890191B2 (en) | 2018-07-12 | 2024-02-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Fastener and techniques therefor |
US11123191B2 (en) | 2018-07-12 | 2021-09-21 | Valtech Cardio Ltd. | Annuloplasty systems and locking tools therefor |
US11350812B2 (en) * | 2018-08-30 | 2022-06-07 | Karl Storz Se & Co. Kg | Endoscope shaft having a layered structure, and method for producing same |
US11202710B2 (en) | 2018-10-10 | 2021-12-21 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11129717B2 (en) | 2018-10-10 | 2021-09-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10945844B2 (en) | 2018-10-10 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10993809B2 (en) | 2018-10-10 | 2021-05-04 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11000375B2 (en) | 2018-10-10 | 2021-05-11 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11083582B2 (en) | 2018-10-10 | 2021-08-10 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11344415B2 (en) | 2018-10-10 | 2022-05-31 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11147672B2 (en) | 2018-10-10 | 2021-10-19 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10987221B2 (en) | 2018-10-10 | 2021-04-27 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11234823B2 (en) | 2018-10-10 | 2022-02-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11766330B2 (en) | 2018-10-10 | 2023-09-26 | Edwards Lifesciences Corporation | Valve repair devices for repairing a native valve of a patient |
US11278409B2 (en) | 2018-10-10 | 2022-03-22 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11839544B2 (en) | 2019-02-14 | 2023-12-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11413174B2 (en) | 2019-06-26 | 2022-08-16 | Covidien Lp | Core assembly for medical device delivery systems |
US11819411B2 (en) | 2019-10-29 | 2023-11-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
WO2022060669A1 (en) * | 2020-09-15 | 2022-03-24 | Medtronic, Inc. | Deflectable delivery system for implant delivery |
US11951263B2 (en) | 2020-10-08 | 2024-04-09 | Edwards Lifesciences Corporation | Multi-direction steerable handles |
US20220126060A1 (en) * | 2020-10-23 | 2022-04-28 | Canon U.S.A., Inc. | Reinforced center lumen for steerable device |
US11944558B2 (en) | 2021-08-05 | 2024-04-02 | Covidien Lp | Medical device delivery devices, systems, and methods |
CN114191685A (en) * | 2021-10-19 | 2022-03-18 | 深圳北芯医疗科技有限公司 | Catheter sheath |
Also Published As
Publication number | Publication date |
---|---|
CN101896217A (en) | 2010-11-24 |
US20190030284A1 (en) | 2019-01-31 |
JP2011505974A (en) | 2011-03-03 |
US8734699B2 (en) | 2014-05-27 |
US20100314031A1 (en) | 2010-12-16 |
US20140303599A1 (en) | 2014-10-09 |
EP2190513A1 (en) | 2010-06-02 |
EP2190513A4 (en) | 2011-11-09 |
JP5769422B2 (en) | 2015-08-26 |
US10912923B2 (en) | 2021-02-09 |
CN101896217B (en) | 2014-11-19 |
US10099036B2 (en) | 2018-10-16 |
WO2009075989A1 (en) | 2009-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10912923B2 (en) | Steerable catheter using flat pull wires and having torque transfer layer made of braided flat wires | |
US11154691B2 (en) | Catheter and method of manufacture | |
US10130791B2 (en) | Catheter and introducer catheter having torque transfer layer and method of manufacture | |
US10625044B2 (en) | Guiding medical devices and associated methods of manufacturing | |
EP2018204B1 (en) | Steerable catheter using flat pull wires and method of making same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, IN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HEIDEMAN, WAYNE;FUENTES, ALLAN M.;STEHR, RICHARD E.;AND OTHERS;REEL/FRAME:020748/0227;SIGNING DATES FROM 20071213 TO 20080225 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |