Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates to a dentifrice composition containing sodium hydrogen carbonate, which gives a high refreshing feeling and is excellent in foaming and foaming performance when brushing teeth.
• an abrasive is generally blended as a cleaning agent, a surfactant such as an anionic surfactant is blended to ensure foaming, and sodium hydrogen carbonate is blended to give a refreshing feeling. (Baking soda) is added.
• sodium hydrogen carbonate is added to the dentifrice composition in order to enhance the refreshing feeling, it may affect the basic performance such as foaming performance, and the salty taste of itself may cause a decrease in usability. ..
• Patent Document 1 Patent No. 5033283 proposes that the bad feeling of use due to a specific bitter component blended in an oral composition can be improved by blending baking soda in a specific amount ratio or more. There is no mention of foam performance.
• Patent Document 2 Japanese Unexamined Patent Publication No. 2018-203640
• an anionic surfactant and xanthan gum are used in combination with a dentifrice composition, and 1.4% by mass or more of each is blended to cause foam dripping from the mouth when brushing teeth. It is proposed that the decrease in the refreshing feeling in the above-mentioned combination system can be eliminated by adding a hydrogen carbonate.
• the present invention has been made in view of the above circumstances, and provides a dentifrice composition containing sodium hydrogen carbonate, which has an excellent foaming performance that gives a high refreshing feeling, moderately foams when brushing teeth, and gives a firm foam.
• the purpose is.
• the present inventor has added (A) a specific amount of sodium hydrogen carbonate (baking soda) to a dentifrice composition containing (B) an anionic surfactant.
• (C) carrageenan and (D) water-soluble zinc salt are combined and blended, it foams moderately, prevents the component (A) from weakening the foam when brushing teeth, and gives a firm foam.
• the refreshing feeling in the oral cavity can be enhanced.
• (A) sodium hydrogen carbonate, (B) anionic surfactant, (C) carrageenan and (D) water-soluble zinc salt are contained, and the content of the component (A) is 0.1 to
• the dentifrice composition which is 2% by mass, gives a high refreshing feeling, moderately foams when brushing teeth, has excellent foaming performance that gives a firm foam, and has a good feeling of use with suppressed saltiness. It has been found that it can be imparted, and the present invention has been made.
• the foaminess during tooth brushing increases as the amount of the component (A) is increased.
• the foam became brittle and fragile, and the foam performance deteriorated due to the feeling of being scuffed, and an unpleasant salty taste was sometimes felt.
• the component (A) is blended in a specific amount and the components (C) and (D) are blended in combination with the dentifrice composition containing the component (B), these four components are blended.
• the combination system of the components (C) and (D) specifically acts as a foam elasticity improving agent, whereby the foam elasticity is not weakened during brushing as described above, and many bubbles are quickly formed.
• a firm foam that is hard to break and feels elastic, thereby ensuring foaming and foaming performance and giving a high refreshing feeling, and suppressing unpleasant salty taste derived from component (A). It was also possible to give a good feeling of use.
• the action and effect of the present invention is a special action and effect obtained by combining the components (A), (B), (C) and (D), and particularly when the component (C) or (D) is lacking, the foam The effect of improving stiffness was inferior.
• the foam is weak even if a relatively large amount of other surfactant is added, and if the component (C) or (D) is lacking, the binder xanthan gum, Even if sodium carboxymethyl cellulose or the like was blended, the foam was weak and the effect of this action was inferior.
• the foam during brushing is inferior in elasticity (Comparative Examples 5 to 5 to D). 7).
• a calcium-based abrasive and / or a silica-based abrasive can be further blended as the (E) abrasive.
• the component (A) weakens the foam is that the component (A) has some action on the foam formed by the component (B). It is presumed that there is.
• the foaming performance such as foaming of the dentifrice composition tends to decrease.
• the dentifrice composition of the present invention even if a calcium-based abrasive is blended as the (E) abrasive, the components (C) and (D) are blended, so that foaming and foaming during brushing are performed. Excellent in elasticity.
• Patent Document 1 Japanese Patent Laid-Open No.
• 2017-514881 discloses an oral care composition in which a zinc ion source such as zinc citrate and a specific thickener system containing carrageenan are blended to improve phase stability.
• a zinc ion source such as zinc citrate
• a specific thickener system containing carrageenan are blended to improve phase stability.
• the formulation of sodium hydrogen carbonate in the dentifrice composition is not mention.
• the present invention is to improve the refreshing feeling and the firmness of foam in the dentifrice composition by combining the components (A), (B), (C) and (D). It exerts a particularly remarkable action and effect that cannot be achieved when the ingredients are lacking.
• the present invention provides the following dentifrice compositions.
• A Sodium bicarbonate
• B Anionic surfactant
• D The dentifrice composition according to [1], wherein the water-soluble zinc salt is at least one selected from zinc gluconate, zinc chloride and zinc citrate.
• B The dentifrice composition according to [1] or [2], wherein the content of the component is 1 to 3% by mass.
• a dentifrice composition containing sodium hydrogen carbonate which has excellent foaming performance that gives a high refreshing feeling, moderately foams when brushing teeth, and gives a firm foam.
• the dentifrice composition of the present invention contains (A) sodium hydrogen carbonate, (B) anionic surfactant, (C) carrageenan and (D) water-soluble zinc salt.
• Sodium hydrogen carbonate has an effect of imparting a refreshing feeling to the dentifrice composition of the present invention.
• the sodium hydrogen carbonate (baking soda) for example, a commercially available product such as a trade name manufactured by Asahi Glass Co., Ltd .; sodium bicarbonate can be used.
• the blending amount of (A) sodium hydrogen carbonate is 0.1 to 2% (mass%, the same applies hereinafter) of the entire composition, preferably 0.3 to 1%. If the blending amount is less than 0.1%, a refreshing feeling cannot be sufficiently imparted. If too much is blended, not only the firmness of the foam is inferior, but also the taste is lowered due to its own salty taste, and if it exceeds 2%, the firmness of the foam is weak and the taste is also deteriorated.
• the anionic surfactant has an action of ensuring foaming.
• the anionic surfactant is preferably an anionic surfactant having a hydrocarbon group such as an alkyl group, an acyl group or an alkenyl group having 10 to 18 carbon atoms, preferably 10 to 16 carbon atoms, and for example, an alkyl sulfate or an acyl amino acid. Examples thereof include salts (acyl sarcosinate, acyl glutamate, etc.), ⁇ -olefin sulfonate, acyl taurine salt, alkylbenzene sulfonate, alkyl sulfoacetate, and the like.
• alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate
• acyl sarcosates such as sodium N-lauroyl sarcosin and sodium N-myristyl sarcosin
• acyl glutamates such as palmitoyl glutamate and lauroyl glutamate
• ⁇ -olefin sulfonates such as sodium decene sulfonate
• acyl taurine salts such as sodium lauroylmethyl taurine and sodium cocoyl methyl taurine
• sodium dodecylbenzene sulfonate sodium hydrogenated coconut fatty acid monoglyceride monosulfate
• sodium lauryl sulfoacetate sodium lauryl sulfoacetate
• alkyl sulphates alkyl sulphates, acyl sulcosates, and ⁇ -olefin sulfonates are preferable in terms of good foaming and foam elasticity. These can be used alone or in combination of two or more.
• sodium lauryl sulfate is a trade name manufactured by Kao Indonesia Chemical Co., Ltd .; EMAL10G-3, etc.
• sodium lauroyl sarcosin is a trade name manufactured by Kawaken Fine Chemicals Co., Ltd .
• K lipolan PJ-400CJ sodium ⁇ -olefin sulfonate having 14 carbon atoms (generic name; sodium tetradecene sulfonate)
• the blending amount of the (B) anionic surfactant is preferably 1 to 3%, more preferably 1.5 to 2.7%, and particularly 1.5 to 2.5% of the entire composition.
• the blending amount is 1% or more, sufficient foaming can be obtained.
• it is 3% or less, the irritation caused by itself is sufficiently suppressed and a good usability is maintained.
• the carrageenan (C) for example, a commercially available product such as a trade name manufactured by CP Kelco; GENUVISCO carrageenan type TPC-1 can be used.
• the blending amount of (C) carrageenan is preferably 0.1 to 1%, more preferably 0.2 to 0.8%, and even more preferably 0.2 to 0.5% of the entire composition. When the blending amount is 0.1% or more, the firmness of the foam is sufficiently improved. When it is 1% or less, the dispersibility of the preparation can be sufficiently ensured.
• the zinc ion of the water-soluble zinc salt contributes to the foam elasticity improving action.
• the effect of imparting a refreshing feeling by the component (A) is enhanced, and the salty taste of the component (A) is suppressed.
• the water-soluble zinc salt include zinc gluconate, zinc chloride, zinc citrate, zinc acetate, zinc lactate, zinc sulfate, zinc nitrate and the like, and hydrates thereof can also be used.
• zinc gluconate, zinc chloride, and zinc citrate are preferable because they have a high effect of improving foam elasticity and have little effect on flavor. These can be used alone or in combination of two or more.
• As the water-soluble zinc salt a commercially available product can be used.
• zinc gluconate is a trade name manufactured by Corpion Co., Ltd .; GLUCONAL ZN-P, etc.
• zinc chloride is a trade name manufactured by Genuine Chemical Co., Ltd .
• zinc chloride, etc. zinc citrate is Fujifilm Wako Pure Chemical Industries, Ltd. Trade name manufactured by Co., Ltd .; zinc chloride dihydrate or the like can be used.
• the amount of the water-soluble zinc salt (D) blended is preferably 0.01 to 0.5%, more preferably 0.05 to 0.2% of the total amount of zinc ions.
• the blending amount (zinc ion amount) is 0.01% or more, the firmness of the foam is sufficiently improved, a refreshing feeling is sufficiently obtained, the salty taste of the component (A) is sufficiently suppressed, and the taste is also improved. good. If too much is added, it affects foaming and the metallic taste of itself may be strongly expressed, but if it is 0.5% or less, appropriate foaming is sufficiently secured and a good taste is maintained.
• (B) / (D) which indicates the ratio between the blending amount of the component (B) and the blending amount of the component (D) as zinc ions, is preferably 3 to 100, more preferably 5 to 50, as a mass ratio. , Especially 8 to 45.
• the mass ratio of (B) / (D) is within the above range, the firmness of the foam is further improved, and an appropriate foaming can be sufficiently ensured. If the mass ratio of (B) / (D) is less than 3, foaming may decrease, and if it exceeds 100, the foam may not be sufficiently firm.
• (E) abrasive can be further blended.
• the abrasive (E) is not particularly limited as long as it is general for a dentifrice composition, but it is preferable to use a calcium-based abrasive and / or a silica-based abrasive.
• Calcium-based polishing agents are polishing agents containing calcium in a compound, such as calcium carbonate, dicalcium phosphate dihydrate or anhydride, calcium primary phosphate, calcium tertiary phosphate, calcium tetraphosphate, calcium pyrophosphate, etc. Calcium phosphate can be mentioned. Of these, calcium carbonate is preferable.
• the silica-based polishing agent is a polishing agent containing silica in a compound, and may be a metal composite silica containing a metal such as aluminum or zirconium. Examples thereof include precipitated silica (silicic anhydride), aluminosilicate, and zirconosilicate. Be done. These can be used alone or in combination of two or more. In addition, commercially available products can be used for these.
• the (E) abrasive preferably contains at least a calcium-based abrasive, and particularly from the viewpoint of cleanability, the main abrasive is a calcium-based abrasive, and it is preferable to use a silica-based abrasive in combination.
• the component (A) affects the foam formed by the component (B), and the foam tends to be weakened. Generally, even if a large amount of calcium ions are eluted, the foam tends to be weak.
• the components (C) and (D) are blended so that the foam is sufficiently firm. It is excellent, and the saltiness is sufficiently suppressed and the taste is good. As described above, particularly in the system in which calcium ions are present, the effect of improving the elasticity of the foam by the components (C) and (D) is remarkable, which is preferable.
• the total amount of the abrasive (E) is preferably 20 to 70% of the total composition. Further, when a calcium-based abrasive is blended, the blending amount can be 20 to 70% of the entire composition, preferably 25 to 50%, and more preferably 30 to 45%.
• the blending amount of the silica-based abrasive is preferably 0 to 20%, more preferably 0 to 5% of the entire composition.
• the main abrasive is a calcium-based abrasive and other abrasives such as silica-based abrasives are blended, the respective blending amounts are totaled and used within the range of the total blending amount of the above-mentioned abrasives. Is preferable.
• the dentifrice composition of the present invention can be prepared as a dentifrice, a liquid dentifrice, etc., but a dentifrice composition is particularly preferable.
• a conventional method can be adopted as the preparation method.
• other appropriate known components may be blended depending on the purpose of the composition, the dosage form, and the like.
• a surfactant, a binder, a wetting agent, and if necessary a sweetening agent, a preservative, a coloring agent, a fragrance, an active ingredient, and the like can be blended.
• the blending amount may be a normal amount as long as the effect of the present invention is not impaired.
• Nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, and poly. Examples thereof include oxyethylene sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, fatty acid alkanolamide, and polyoxyethylene polyoxypropylene glycol.
• polyoxyethylene fatty acid ester having a hydrocarbon group having 12 to 18 carbon atoms and having an average addition molar number of ethylene oxide of 3 to 40, and ethylene oxide having a hydrocarbon group having 12 to 18 carbon atoms
• Polyoxyethylene higher alcohol ether having an average addition molar number of 3 to 30, and polyoxyethylene polyoxypropylene glycol having a molar ratio (EO / PO) of oxyethylene (EO) to oxypropylene (PO) of 1 to 6
• polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 10 to 40 is particularly preferable in terms of a refreshing feeling.
• the amphoteric surfactant includes betaine type acetate such as alkylbetaine and fatty acid amide propyl betaine, betaine type such as alkylimidazolinium betaine, and imidazoline type such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt. Examples thereof include imidazolium betaine types such as 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine.
• the blending amount of the nonionic surfactant is preferably 0.05 to 1%, particularly 0.1 to 0.5% of the entire composition. The lower the amount of nonionic surfactant, the more refreshing feeling can be obtained.
• the blending amount of the amphoteric surfactant is preferably 0.1 to 2%, particularly 0.1 to 1% of the entire composition.
• an organic binder other than (C) carrageenan and / or an inorganic binder can be blended.
• examples thereof include organic binders such as xanthan gum, sodium alginate, sodium carboxymethyl cellulose and sodium polyacrylate, and inorganic binders such as thickening silica and thickening aluminum silica.
• the amount of the organic binder is preferably 0 to 2%, particularly 0.1 to 1.3% of the entire composition, and the amount of the inorganic binder is 1 of the entire composition. ⁇ 10%, especially 3-8% is preferable.
• wetting agent examples include polyhydric alcohols such as glycerin, polyethylene glycol and propylene glycol, and sugar alcohols such as sorbitol.
• the blending amount of the wetting agent is preferably 5 to 40%, particularly 10 to 30% of the whole composition.
• sweetening agent examples include sodium saccharin and the like.
• preservative examples include paraoxybenzoic acid ester, benzoic acid or a salt thereof.
• colorant examples include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like.
• Fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime.
• fragrance lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil , Yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower and other natural fragrances, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid extraction, essence, powder fragrance Perfume, menthol, carboxylic, anator, cineole, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timol, linalol, linaryl acetate, limonene, menton , Menthylacetate, N-substituted-paramentan-3-carboxamide, pinen, octylaldehyde, citral, pregon, calvier acetate, anis
• the active ingredients are fluorine-containing compounds such as sodium fluoride, sodium monofluorophosphate and tin fluoride, whitening ingredients such as sodium polyphosphate, and bactericidal ingredients such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride and benzethonium chloride.
• Anti-inflammatory components such as dipotassium glycyrrhizinate, glycyrrhetinic acid, ⁇ -aminocaproic acid, hypersensitivity suppressing components such as potassium nitrate and aluminum lactate, mouth odor suppressing components such as copper gluconate, and tissue repair components such as allantoin.
• the active ingredient can be used in an effective amount as long as it does not interfere with the effects of the present invention.
• a medium-chain fatty acid triglyceride (usually, the blending amount is usually 0.01 to 0.5% of the whole composition) can be added as an oily component, and a pH adjuster is added, preferably pH 6 to. It can also be adjusted to 10 (25 ° C).
• the water content in the composition is preferably 10 to 40%, particularly preferably 20 to 30%.
• Toothpaste compositions (dentifrice compositions) having the compositions shown in Tables 1 to 4 were prepared by a conventional method and evaluated by the following method. The results are also shown in Tables 1 to 4.
• (B) / (D) is a mass ratio of (blending amount of component (B)) / (blending amount of component (D) as zinc ion).
• each subject brushed about 1 g of the dentifrice composition with a toothbrush, brushed for 3 minutes, and then rinsed the oral cavity with water.

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• 2020
  • 2020-03-23 JP JP2021511475A patent/JPWO2020203409A1/ja active Pending
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  • 2020-03-23 CN CN202080027342.6A patent/CN113710328B/zh active Active
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