WO2020098355A1 - 皮肤外用剂组合物 - Google Patents

皮肤外用剂组合物 Download PDF

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Publication number
WO2020098355A1
WO2020098355A1 PCT/CN2019/105171 CN2019105171W WO2020098355A1 WO 2020098355 A1 WO2020098355 A1 WO 2020098355A1 CN 2019105171 W CN2019105171 W CN 2019105171W WO 2020098355 A1 WO2020098355 A1 WO 2020098355A1
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Prior art keywords
composition
thickener
oil
present
skin
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Ceased
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PCT/CN2019/105171
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English (en)
French (fr)
Chinese (zh)
Inventor
韩扬
曲睿
渡边启
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Shiseido Co Ltd
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Shiseido Co Ltd
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Priority to JP2021525559A priority Critical patent/JP7350067B2/ja
Publication of WO2020098355A1 publication Critical patent/WO2020098355A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • the invention belongs to the technical field of skin care products, and relates to a composition system having a synergistic viscosity-increasing effect, and more specifically, to a composition for external use of skin.
  • compositions for external use of skin are widely used in cosmetic products.
  • Such compositions usually include an aqueous system and an oily system.
  • Aqueous systems are widely used in cosmetic products. While playing a specific function, they can also give people a refreshing feeling.
  • water or an aqueous substance serves as a continuous phase, and the oily component serves as a dispersed phase, forming a liquid or semi-solid system.
  • the usual oil-in-water composition contains various active ingredients to achieve effects such as moisturizing, supplementing nutrition, protection or repair.
  • various additives such as various emulsifiers, stabilizers, thickeners, preservatives and other ingredients may be added.
  • the stability of the system is important for oil-in-water compositions containing multiple active ingredients.
  • phase separation within the system is likely to occur during production, transportation, storage, or use, resulting in a deterioration of the external appearance of cosmetics.
  • the presence of multiple active ingredients makes it difficult to operate when forming stable oil phase droplets suspended or dispersed in an aqueous continuous phase in a desired form.
  • the introduction of more active ingredients often leads to the use of more kinds or amounts of additives. Therefore, the safety of the product is also the focus of attention.
  • non-ionic surfactants such as polyoxyethylene alkyl ethers and sorbitan fatty acid partial esters are mainly used.
  • those surfactants inevitably have different degrees of stimulation to the skin. Therefore, the amount of surfactants should be reduced as much as possible, and sometimes try to emulsify without using these surfactants, but the uniformity and stability of the emulsion Problems such as sexuality are prone to occur, and it may not be possible to obtain an emulsion that meets the requirements.
  • emulsifiers derived from natural substances is discussed.
  • the use of fermented grains of grains as emulsifiers or stabilizing ingredients is also known, for example:
  • Reference 1 discloses a product LAFR- ⁇ obtained by fermentation using rice as a raw material, and studies the surface tension and interfacial tension of LAFR- ⁇ , and studies the emulsification behavior exhibited by LAFR- ⁇ and contains LAFR- ⁇ The oxidation resistance of the suspension system.
  • Reference 2 discloses a lotion containing fermented rice bran, which contains 0.01-10% by mass of fermented rice bran, and the lotion has a low viscosity of 1000 mPa ⁇ s or less.
  • Reference 3 discloses an emulsifying aid, which is mainly composed of rice fermented by lactic acid bacteria obtained by fermentation of rice with lactic acid bacteria. Fermented rice obtained by fermenting rice with lactic acid bacteria has good emulsifying ability, emulsification stabilizing effect and even protective colloid-like effect. At the same time, since it comes from rice, it has low toxicity, little irritation to the skin, and safety to organisms High, it can be used as a basic raw material for emulsifiers or emulsion stabilizers for cosmetics. In addition, it has been unexpectedly found that the fermented rice shows significant whitening, skin beautifying and hair quality improving effects, and can also be used as a cosmetic effect Compounding agent.
  • fermented cereal products are also found in Reference 4, which relates to a fermented product of cereals and ginseng stems and leaves and its application in skin cleansing products.
  • the method first heat sterilizes the culture medium containing grains or ginseng stems and leaves, and then inserts microorganisms, fermentes, and sterilizes to obtain a fermentation product containing cells, fermentation filtrate, and solid particles.
  • the fermentation product is used in cleaning products. It has a good effect of removing oil from the skin surface, smoothing the skin, anti-inflammatory, acne and so on. And it has the characteristics of nourishing the skin, gently exfoliating the skin, low irritation, safe and gentle.
  • oil-in-water composition in order to obtain a stable form of the oil-in-water composition, for example, to enable oily droplets to be suspended in the system stably for a longer time, it is necessary to give the oil-in-water composition system a certain viscosity or consistency Therefore, under normal circumstances, it is necessary to add a certain amount of thickener to obtain the stability effect.
  • thickeners are synthetic polymers or chemically modified natural polymers.
  • Reference 5 discloses an oil-in-water emulsified skin external preparation.
  • This emulsion preparation is obtained by using hydroxylated phospholipids and lactic acid bacteria fermentation materials of grains and alkyl-modified acrylic-based polymers and / or their salts as essential ingredients.
  • the grain fermentation product is used as an emulsifier
  • the alkyl-modified acrylic polymer and / or its salt is used as a thickener
  • the hydroxylated phospholipid is used as a stabilizer.
  • Reference 5 verifies that the combined use of the above three components is a necessary condition to obtain a stable emulsion system (that is, the phenomenon of water phase separation and oil phase separation does not occur). The desired effect.
  • the present invention mainly relates to the synergistic use of cereal fermentation products and additives in existing skin external preparation compositions.
  • the present invention provides a skin external preparation composition having a synergistic viscosity-increasing effect.
  • a grain fermentation product generally used only as an emulsifier and a polyacrylic acid and its derivative thickener are more
  • carbohydrate thickeners were used simultaneously, it was unexpectedly observed that the simultaneous use of both can significantly increase the viscosity of the system, produce a synergistic thickening effect, and obtain a stable system compared to the case of using the thickener alone.
  • the molecular side chain structure of the polyacrylic acid and its derivative thickener contains the structure of the following formula (1):
  • R 1 is an alkylene group having 2-6 carbon atoms
  • R 2 is an alkyl group having 1-50 carbon atoms
  • n represents an integer of 0-100
  • L is a single bond or a divalent linking group.
  • the present invention first provides a composition for external use of skin, wherein the composition includes:
  • the (B) thickener is selected from polyacrylic acid and its derivative thickener or polysaccharide thickener,
  • the molecular side chain structure of the polyacrylic acid and its derivative thickener contains the structure of the following formula (1):
  • R 1 is a linear or branched alkylene group having 2 to 6 carbon atoms
  • R 2 is a linear or branched alkyl group having 1 to 50 carbon atoms
  • n represents 0 to 100 Integer
  • L represents a single bond or a divalent linking group.
  • composition according to [2] wherein the cereal is selected from one or more of rice, glutinous rice, millet, black rice, corn, and sorghum.
  • composition according to [1] or [2], wherein the fermentation is performed in the presence of lactic acid bacteria is performed in the presence of lactic acid bacteria.
  • composition according to any one of [1] to [3], wherein the composition has a viscosity of 1200 mPa ⁇ s or more.
  • the present invention also provides a cosmetic, wherein the cosmetic includes the skin external agent composition according to any one of the above.
  • fermented grains especially rice fermented materials and thickeners
  • the cosmetics containing the skin external preparation composition of the present invention can give the user a refreshing, non-sticky, and smooth feeling of use when used.
  • FIG. 1 Viscosity changes when different amounts of PEMULEN are used in conjunction with grain fermentation
  • the active ingredient of the fermented product obtained after the fermentation of cereals can be used as an emulsifier or a nutritional ingredient.
  • the present invention unexpectedly discovered that when such a fermented grain is used together with the thickener defined by the present invention, it can produce a synergistic thickening effect with the thickener defined by the present invention.
  • the cereal in the present invention may be one or more selected from rice, glutinous rice, millet, black rice, corn, and sorghum.
  • rice or glutinous rice is preferred, and rice is further preferred.
  • the grains in the present invention may be grains with or without processing, for example, may be any one or more of brown rice, polished rice, processed rice, etc., which are not particularly limited, and in some preferred embodiments of the present invention In order to facilitate the fermentation or the purity of the obtained fermentation product, processed grains, such as polished rice or processed rice, are generally used.
  • the method of fermentation is not particularly limited, and microorganisms can be used to ferment grains, preferably using lactic acid bacteria.
  • these lactic acid bacteria that can be used for grain fermentation include Lactobacillus plantarum, L. brevis, L. casei, and L. cellobiosus. , L. vaccinostercus, Streptococcus faecalis, Bacillus coagulans, etc.
  • Lactobacillus plantarum is preferably used from the viewpoint of emulsifying ability of the obtained fermented rice of lactic acid bacteria.
  • the grains are also pre-treated before fermentation, and the pre-treatment includes screening or washing.
  • the grains are processed, and suitable pretreatment methods such as washing are applied to remove possible impurities or other bacteria that hinder the fermentation of lactic acid bacteria, to obtain grains with relatively pure ingredients, such as clean refined rice.
  • the above-mentioned refined rice is placed in a fermentation container, which is airtight, so that the subsequent fermentation process can be performed under anaerobic conditions.
  • water, lactic acid bacteria, and fermentation auxiliary components are introduced into the fermentation vessel.
  • the water is preferably distilled water or purified water, and the amount thereof is not particularly limited, and can generally be less than 10 times the mass of the grains (finished rice) after processing and pretreatment.
  • the fermentation auxiliary component can be selected from various carbohydrates, and glucose, fructose, galactose, sucrose, etc. can be used, among which fructose is most preferably used.
  • the container is closed so that the fermentation can be performed under anaerobic conditions.
  • the temperature and time of the fermentation are not particularly limited, and the usual fermentation method can be followed.
  • fermentation may be performed under room temperature conditions or under heating conditions, and the fermentation time may be several days or weeks.
  • the lactic acid bacteria-containing fermentation liquid obtained by the above fermentation step can be used as an active ingredient as it is.
  • the obtained fermentation liquid may also be purified or concentrated.
  • the means of purification is not particularly limited, and filtration may be performed under normal pressure or under reduced pressure.
  • the concentration method can be carried out using distillation or the like.
  • a concentration step can be carried out after purification.
  • (B) thickeners in the present invention can impart a certain viscosity to the composition for external use on skin, and in some preferred embodiments, impart a certain viscosity to the aqueous composition.
  • the (B) thickener of the present invention is selected from polyacrylic acid and its derivative thickeners or polysaccharide thickeners.
  • the polyacrylic acid and its derivative thickener of the present invention may be a polymer or its derivative obtained by copolymerizing acrylic acid and acrylate.
  • the molecular side chain structure of the polyacrylic acid and its derivative thickener contains the structure of the following formula (1):
  • R 1 is a linear or branched alkylene group having 2 to 6 carbon atoms, preferably a linear or branched alkylene group having 2 to 4 carbon atoms
  • R 2 is a carbon atom having A linear or branched alkyl group of 1-50, preferably a linear or branched alkyl group having 6 to 30 carbon atoms, and more preferably a linear or branched alkyl group of 10-25, where n represents An integer of 0-100, preferably an integer of 1-100, further preferably an integer of 6-50, even more preferably an integer of 10-30, L represents a single bond or a divalent linking group, preferably an alkylene group group.
  • the thickener of the present invention can be regarded as copolymerized with acrylic acid and alkyl acrylate.
  • polyacrylic acid and its derivative thickener may have the following molecular structure:
  • R and R ' may be alkyl groups having 10 to 30 carbon atoms.
  • Thickeners with such a structure can be obtained commercially, for example TR-1, TR-2.
  • n in the side chain of the thickener of polyacrylic acid and its derivatives is 1-30, that is, there is a polyoxyalkylene structure in the side chain, which may be cited,
  • the polyoxyalkylene group may have a polyoxyethylene or polyoxypropylene structure.
  • it may have an ester structure, for example, it may be an ester formed by acrylic acid and an alcohol having 1-6 carbon atoms, Typically, it has the following structure:
  • R may be H or an alkyl group having 1 to 4 carbon atoms.
  • thickeners with such structures are commercially available, for example, ACULYN TM series thickeners under the name of DOW Chemicals.
  • the polyacrylic acid and its derivative thickener used in some embodiments of the present invention may have an amide and sulfonate (salt) group in its side chain .
  • the structures that can be enumerated are:
  • Thickeners with such a structure can be obtained commercially, for example HMB series thickener, etc.
  • the molecule may have a certain cross-linked structure, for example, physical cross-links formed by hydrogen bonds or cross-links formed by ionic bonds.
  • starch and cellulose thickeners can be used, and preferably, the cellulose thickener is used in the present invention.
  • alkyl and / or polyalkoxy segments are used for etherification modification in the molecule.
  • modified cellulose obtained by modifying cellulose, which is obtained by alkylating (etherifying) the hydroxyl group on one unit ring of the fiber is optional. That is, the modified cellulose has the following structure:
  • R may be H, an alkyl group having 1-4 carbon atoms,-(R a O) m -R b or -R c OR d , where R a represents an alkylene group having 1-4 carbon atoms , R b represents H or an alkyl group having 1 to 4 carbon atoms, R c represents an alkylene group having 1 to 4 carbon atoms, and is optionally substituted with a hydroxyl group, and R d represents 10 to 30 carbon atoms Alkyl, m is an integer of 1-100.
  • the thickeners having the above structure can be listed under the name of DAIDO Products, etc.
  • the form when these thickeners are used is not particularly limited, and for example, they can be used in the form of an aqueous solution or another solution.
  • the above-mentioned thickener may be used in the form of an emulsion, especially an oil-in-water emulsion.
  • such a solution may also contain other auxiliary stabilizing ingredients, such as acids, alkalis or salts as stabilizing ingredients.
  • the present invention found that even in the absence of other viscosity-increasing ingredients, when the thickener is used synergistically with the fermented grain, the viscosity will be higher than that of the system using only or having the thickener Substantial growth.
  • the amount of the thickener is such that the viscosity obtained due to the above-mentioned synergistic effect is 1.2 times or more the viscosity of the system using only or having the thickener, preferably 2 times, 4 times, 4.1 times , 4.5 times, 6 times or 10 times or more, more preferably 20 times, 30 times, 50 times or 70 times.
  • the viscosity of the following system X is determined and set to ⁇ , the system X contains:
  • the balance is water.
  • the balance is water.
  • the necessary stability ingredients mentioned above are preservatives and / or pH adjusters.
  • the skin external preparation composition of the present invention is a functional composition suitable for use on the surface of human skin. Usually such compositions have multiple functional ingredients. Common skin external preparation compositions can be used in the form of liquids, gels, and semi-solids. In the present invention, the preferred external skin preparation composition is used in the form of an aqueous composition or an oil-in-water composition.
  • the skin external preparation composition of the present invention is formed with the above components (A) and (B) as essential components.
  • the skin external agent composition is an aqueous composition, which can be obtained by dissolving or suspending various components in water as a matrix.
  • the composition may be a homogeneous solution system or an aqueous system containing insolubles.
  • the external skin composition is an oil-in-water composition.
  • oil-in-water composition means that the oil phase as the dispersed phase is dispersed in the water phase as the continuous phase by means of dispersion aids to form an emulsified composition.
  • the oil phase as the dispersed phase exists in the form of particles. It should be noted that in some embodiments, the “particles” used in the present invention may exist in the form of beads or approximately beads.
  • the composition is mainly water or an aqueous substance, preferably deionized water or distilled water.
  • the mixing amount of water in the composition is not particularly limited, and it is blended in a sufficient amount to make the whole 100%. However, it is usually 50 to 99% by mass relative to the total mass of the composition, preferably 60 to 98% by mass, and more preferably 70 to 95% by mass.
  • a dispersed phase may also be present in the composition of the present invention, and various oils may be used. It can be selected from substances used in general cosmetics within a range that does not impair stability. Examples of preferred oil components include hydrocarbon oil, silicone oil, ester oil, and other liquid fats and oils.
  • hydrocarbon oil liquid paraffin, squalane, squalene, paraffin, isoparaffin, ozokerite, petrolatum, hydrogenated polydecene and the like can be used.
  • silicone oils include chain organic silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; octamethylcyclotetrasiloxane, decamethyl Cyclic silicones such as cyclopentasiloxane and dodecylcyclohexasiloxane; silicone resins and silicone rubbers with a three-dimensional network structure.
  • liquid fats there are: palm oil, palm kernel oil, linseed oil, camellia oil, macadamia oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil , Sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, triglyceride, glyceryl tricaprylate, glyceryl triisopalmitate, etc.
  • ester oil there are: cetyl caprylate, hexyl laurate, isopropyl myristate, octyl palmitate, isocetyl stearate, isopropyl isostearate, octyl isopalmitate, oleic acid Isodecyl ester, cetyl ethylhexanoate, triglyceride of 2-ethylhexanoic acid, pentaerythritol tetra-2-ethylhexanoate, 2-ethylhexyl succinate, diethyl sebacate and the like.
  • the composition of the present invention is not particularly limited, and the blending amount of the oil phase component is preferably about 20% by mass or less.
  • the oil phase component refers to a component that is mixed as an oil phase and dispersed and emulsified in the water phase when producing an oil-in-water composition; specifically, it contains an oil-soluble preservative and oil-soluble ultraviolet rays in addition to the aforementioned oil component Absorbent, oil-soluble agent, oily antioxidant, oily fragrance, etc. If the oil phase component is more than 20% by mass, it becomes oily and feels sticky, which is not preferable.
  • the external composition for skin of the present invention may contain the usual ingredients used in an external composition for skin, such as cosmetics, in an amount that does not substantially impair the effects of the present invention based on the above-mentioned essential ingredients.
  • the usual components include surfactants, moisturizers, powders, alcohols, water-soluble polymers, oil-soluble polymers, film-forming agents, resins, ultraviolet absorbers, and antiseptics other than the above.
  • Agents antibacterial agents, fragrances, salts, antioxidants, pH adjusters, chelating agents, cooling agents, anti-inflammatory agents, skincare ingredients (whitening agents, cell activators, skin roughness improvers, blood circulation enhancers, skin astringents Agents, antiseborrheic agents, etc.), vitamins, amino acids, nucleic acids, hormones, inclusion compounds, etc.
  • the skin external preparation composition obtained by the present invention has a viscosity of 200,000 mPa ⁇ s or 150,000 mPa ⁇ s or 100,000 mPa ⁇ s or 50,000 mPa ⁇ s or 10,000 mPa ⁇ s (30 ° C) or less and 1200 mPa ⁇ s or 1500mPa ⁇ s or 2000mPa ⁇ s or 3000mPa ⁇ s (30 °C) or more, to maintain a good sense of use, will not produce a sticky feeling, and bring consumers a refreshing skin feel. It is further preferred to have a viscosity of 4000-9000 mPa ⁇ s (30 ° C). If the viscosity is too low, it may affect the effect of the product when it is used, and if the viscosity is too high, there will be concerns that it is not conducive to coating and affects the sense of use.
  • the preparation method of the external preparation for skin of the present invention can be obtained by using a general method of mixing the composition.
  • the skin external preparation composition of the present invention is manufactured in the form of an aqueous composition or an oil-in-water composition.
  • the aqueous composition or the oil-in-water composition can be produced by a method for producing a commonly used composition.
  • the water phase component and the oil phase component may be mixed at the same temperature, and the oil phase may be added to the water phase while stirring to disperse and emulsify the mixture, which is suitable for cooling. .
  • the method of forming the oil-in-water composition in the present invention is not particularly limited, and mechanical mixing may be used to provide the necessary mixing shear, or ultrasonic treatment may be used to mix the oil phase component and the water phase component. Get a stable emulsion.
  • the device for preparing the external preparation for skin of the present invention is not particularly limited as long as it can satisfy the above requirements.
  • the external preparation for skin of the present invention may be in the form of a solution, an emulsion, or the like, and may be in a translucent or opaque form.
  • Grain ferment
  • PEMULEN TM (purchased from Lubrizol Corporation)
  • Aristoflex TM (purchased from Clariant)
  • Test temperature 30 °C.
  • a composition was formed according to the following composition, and its viscosity was measured. For data, see Table 1.
  • composition was formed according to the following composition, and its viscosity was measured. For data, see Table 2.
  • composition was formed according to the following composition, and its viscosity was measured. For data, see Table 3.
  • composition was formed according to the following composition, and its viscosity was measured. See Table 4 for data.
  • composition was formed according to the following composition, and its viscosity was measured. For data, see Table 5.
  • composition was formed according to the following composition, and its viscosity was measured. For data, see Table 6.
  • Example 1-1 Comparing Example 1-1 and Comparative Example 1-1, the viscosity of Example 1-1 is about 4.06 times the viscosity of Comparative Example 1-1, comparing Example 1-2 with Comparative Example 1-2, Example 1 The viscosity of -2 is about 6.57 times that of Comparative Example 1-2.
  • composition was formed according to the following composition, and its viscosity was measured. For data, see Table 7 and FIG. 1, where FIG. 1 is based on the data in Table 7.
  • the amount of PEMULEN in the present invention is preferably 0.06-0.2% by mass.
  • composition of the present invention can be used as a thickening system in aqueous cosmetic compositions.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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PCT/CN2019/105171 2018-11-12 2019-09-10 皮肤外用剂组合物 Ceased WO2020098355A1 (zh)

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Application Number Priority Date Filing Date Title
JP2021525559A JP7350067B2 (ja) 2018-11-12 2019-09-10 皮膚外用剤組成物

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CN201811339073.8 2018-11-12
CN201811339073.8A CN111166701B (zh) 2018-11-12 2018-11-12 皮肤外用剂组合物

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