WO2018190248A1 - アレルゲン低減化組成物 - Google Patents

アレルゲン低減化組成物 Download PDF

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WO2018190248A1
WO2018190248A1 PCT/JP2018/014657 JP2018014657W WO2018190248A1 WO 2018190248 A1 WO2018190248 A1 WO 2018190248A1 JP 2018014657 W JP2018014657 W JP 2018014657W WO 2018190248 A1 WO2018190248 A1 WO 2018190248A1
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allergen
acid
salt
materials
zinc
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PCT/JP2018/014657
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English (en)
French (fr)
Japanese (ja)
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圭一郎 乾
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住化エンバイロメンタルサイエンス株式会社
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Publication of WO2018190248A1 publication Critical patent/WO2018190248A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
    • D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/44—Oxides or hydroxides of elements of Groups 2 or 12 of the Periodic Table; Zincates; Cadmates

Definitions

  • the present invention relates to an allergen-reducing composition for reducing allergens such as mites and pollen, or for imparting a function of reducing allergens to nonwoven fabrics, fibers or textiles, building interior materials and the like.
  • Allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis are troubled by many people, and in recent years, the tendency is increasing.
  • the causes of these allergic diseases are various allergens present in the environment.
  • mites, pet hair, pollen, and mold that inhabit indoors are typical inhalable allergens.
  • leopard mites which are dust mites that live in the house, are a major problem as a source of allergens.
  • Lion mites are a hotbed for growing textile products in the house such as tatami mats, carpets, bedding, curtains, etc., or seat sheet fabrics of moving vehicles such as trains and cars outdoors.
  • a vacuum cleaner is an effective method for removing allergens, but a large amount of allergens contained in the sucked garbage is only stored in the dust bag, and there is a risk that the allergen will re-scatter when the dust bag is discarded. It is done.
  • Tannic acid has long been known as a drug for reducing or eliminating allergenicity of allergen substances, and a method of applying a polyphenol compound such as tannic acid has been proposed.
  • a method of using tannic acid as an allergen inactivating agent (Patent Document 1), tea extract, hydroxyapatite, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, gallic acid and gallic acid
  • Patent Document 2 A method of using an ester with an alcohol having 1 to 4 carbon atoms as an allergen inactivating agent. Tannic acid is an excellent agent because it is a highly safe natural product and has an excellent allergen-reducing effect, but it is colored brown and the coloration progresses over time.
  • there is a problem that the use is limited because it is easily colored due to corrosion of metals such as iron.
  • Allergen-reducing compositions using zinc compounds include zinc inorganic salt compounds such as zinc oxide, zinc chloride, zinc sulfate, and zinc nitrate, and water-soluble zinc compounds such as zinc acetate, allergen-reducing components and removal. It has been proposed as an agent, neutralizing composition or inactivating agent (Patent Documents 3 to 7). An allergen-reducing composition using a rare earth salt has also been proposed (Patent Document 8). However, the effect of reducing allergens was not always satisfactory.
  • An allergen-reducing composition capable of imparting a function of reducing allergens to non-woven fabrics, fibers or textiles, building interior materials, etc., without reducing allergens such as mites and cedar pollen, and It is an object of the present invention to provide a nonwoven fabric, a fiber or a fiber product, and an architectural interior material obtained by processing these allergen-reducing compositions.
  • compositions containing both zinc salt and rare earth salt compounds dramatically reduces the high allergen. And found that this composition can reduce allergens such as mites and cedar pollen, thereby completing the present invention.
  • this invention solves the said subject by providing the invention as described in the following (1) to (6).
  • An allergen-reducing composition containing one or more compounds selected from zinc salts and one or more compounds selected from rare earth salts.
  • (2) (A) one or more compounds selected from zinc salts, (B) one or more compounds selected from rare earth salts, and (C) glycol ethers, The allergen-reducing composition as described in 1).
  • (3) The allergen-reducing composition according to (1) or (2), wherein the zinc salt is zinc hydroxy acid.
  • the allergen-reducing composition according to (3), wherein the zinc hydroxy acid is zinc gluconate.
  • allergen-reducing composition of the present invention interiors such as indoor floors, carpets, sofas, wallpaper, curtains, futon side areas, futon covers, futon batting, sheets, pillow covers, mats and other beddings, cars
  • agents that can be sprayed on automobile parts such as sheets and car mats, stuffed animals, etc., and by processing into non-woven fabrics, textiles or textile products, interior materials for construction, etc., mites and cedar pollen etc.
  • interior materials for buildings such as filter materials having a function of reducing allergens, non-woven fabrics such as masks, fibers or fiber products, flooring materials, ceiling materials, and wallpaper.
  • the zinc salt used in the present invention may be any compound as long as it is a water-soluble zinc salt, an inorganic zinc salt such as zinc sulfate or zinc chloride, or an organic acid zinc salt such as zinc acetate or zinc propionate.
  • a zinc salt of a hydroxy acid is desirable.
  • Hydroxy acids are carboxylic acids having one or more hydroxyl groups. Specific examples include glycolic acid, glyceric acid, gluconic acid, glucuronic acid, lactic acid, tartronic acid, 2-hydroxybutyric acid, and 3-hydroxybutyric acid.
  • gluconic acid Malic acid, tartaric acid, citramalic acid, citric acid, isocitric acid, leucine acid, mevalonic acid, pantoic acid, ricinoleic acid, shikimic acid, and the like.
  • gluconic acid, citric acid, and lactic acid are preferred, and gluconic acid is also preferred. Is more preferable.
  • zinc gluconate has an acute oral toxicity exceeding 5000 mg / kg in rats and is very safe. It is used as a substitute for breast milk and as a health functional food for the purpose of prevention and treatment of zinc deficiency. ing.
  • the rare earth salts used in the present invention are scandium salt, yttrium salt, lanthanum salt, cerium salt, praseodymium salt, neodymium salt, samarium salt, europium salt, gadolinium salt, terbium salt, dysprosium salt, holmium salt, erbium salt, thulium salt Ytterbium salt and lutetium salt, lanthanum salt, cerium salt, erbium salt and ytterbium salt are particularly preferable, and lanthanum salt and cerium salt are more preferable.
  • these rare earth salts those commercially available as general reagents or industrial raw materials can be used.
  • any salt having any counter ion can be used, such as chloride salt, sulfate salt, nitrate salt, bromide salt, iodide salt, carbonate salt, phosphate salt, organic acid salt, hydroxide, etc. It can be illustrated.
  • organic acid salts include monovalent or divalent carboxylic acids and salts of hydroxy acids. Specific examples of hydroxy acids include lactic acid, gluconic acid, tartaric acid, citric acid, and malic acid. Examples of the valent carboxylic acid include acetic acid, propionic acid, malonic acid, succinic acid, glutaric acid, adipic acid, and azelaic acid. Of these, chloride salts and hydroxy acid salts are preferable, and chloride salts, gluconates, and lactates are more preferable.
  • hydroxy acid rare earth salt those commercially available as general reagents and industrial raw materials can be used, but it can also be prepared from hydroxy acids and general-purpose inorganic rare earth salts and rare earth oxides. is there.
  • these hydroxy acids for preparation those commercially available as reagents and industrial raw materials can be used.
  • the preparation includes a method in which a rare earth oxide is directly reacted with an aqueous solution of hydroxy acid.
  • a rare earth salt hydroxide is prepared in advance by reacting an alkali metal hydroxide with an aqueous solution of an inorganic rare earth salt such as chloride, and further a hydroxy acid is reacted with the hydroxide to prepare a rare earth hydroxy acid.
  • the alkali metal hydroxide include sodium hydroxide, potassium hydroxide and lithium hydroxide, and sodium hydroxide is preferable.
  • Glycol ether is diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, diethylene glycol monopropyl ether, diethylene glycol monoisopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monophenyl ether, diethylene glycol monobenzyl ether, diethylene glycol dimethyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether , Ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monobenzyl ether or ethylene glycol dimethyl ether Etc., and ethylene glycol monophenyl ether.
  • the allergens targeted by the allergen-reducing composition of the present invention include the allergen (Der p1) derived from the feces of Dermatophagoides pteronyssinus , the allergen derived from the worm body (Der p2), and the Dermatophagoid mite ( Dermatophagoid mite ).
  • Examples include allergen (Der f1) and worm-derived allergen (Der f2).
  • allergens such as cypress, ragweed, mugwort, camogaya, and hurghaya are mentioned, starting with the allergen (Cry j1) derived from pollen of cedar ( Cryptomeria japonica ).
  • allergens derived from dog hair and dandruff can f1, Can f2), feline hair and dandruff allergens (Fel d1), cockroach-derived allergens (Brag 1, Bra g 2), fungi allergens ( Alt a1), natural rubber latex-derived allergen and the like.
  • allergens derived from ticks and allergens derived from cedar pollen are regarded as important as allergens that particularly require reduction.
  • Various allergens listed above can be reduced by using the composition of the present invention, and non-woven fabrics, fibers or fiber products processed from the composition of the present invention, and interior materials for buildings. It can be virtually eliminated.
  • Non-woven fabric, fiber or textile product As an application to which the allergen-reducing composition of the present invention is applied, for example, processing into a non-woven fabric, fiber or textile product is conceivable.
  • Textiles or textile products include clothing, carpets, sofas, wallpaper, curtains, and other interior items, futon linings, futon covers, futon batting, sheets, pillow covers, mats and other bedding, car seats, car mats, and other automobiles.
  • Examples include non-woven fabrics, stuffed animals, etc.
  • Nonwoven fabrics include wet wipers for cleaning, masks, filter materials, and dust collection bags for vacuum cleaners.
  • non-woven fabrics and fibers that can be used to process the allergen-reducing composition of the present invention.
  • examples include nylon, cotton, polyester, wool, and the like, and composite fibers using two or more of these fibers. It doesn't matter. It can also be used for non-woven fabrics using polyethylene or polypropylene.
  • the method for processing the allergen-reducing composition of the present invention into a non-woven fabric, fiber, or fiber product is not particularly limited, and immersion treatment, spray treatment, exhaustion processing, and the like can be performed.
  • examples of the interior material for building include wallpaper using resin such as PVC, wood materials such as ceiling materials and plywood, floor materials, etc., and surface treatment agents and coating agents for surface treatment of these interior materials. Also included are paints and the like.
  • the allergen-reducing composition of the present invention is treated on these building interior materials, it is preferably performed by surface processing. In particular, it can be effectively processed by adding to a water-soluble or aqueous surface treatment agent or coating agent. Moreover, it is preferable to add to an aqueous coating material with respect to a coating material.
  • aqueous surface treatment agent those generally marketed as industrial products can be used.
  • a surface treatment agent is not particularly limited, and examples thereof include various modified starches such as starch and enzyme-modified starch, water-soluble polymers such as polyvinyl alcohol, polyacrylamide and carboxymethylcellulose, and acrylic resin emulsions.
  • aqueous resin emulsions such as vinyl acetate resin emulsions, acrylic-styrene resin emulsions, acrylic-vinyl acetate resin emulsions, vinyl chloride resin emulsions, vinyl chloride-acrylic resin emulsions, and urethane resin emulsions.
  • an aqueous resin emulsion that can be expected to have water resistance of the cured film, rather than using a water-soluble polymer.
  • “Aqueous” means that the polymer contained in the surface treatment agent is soluble in water, or that the water-insoluble polymer is dispersed in water or a polar solvent in the form of a resin emulsion.
  • Such an aqueous surface treatment agent can be macroscopically and uniformly mixed with water at an arbitrary ratio.
  • Boncoat registered trademark, manufactured by DIC Corporation
  • vinyl chloride resin emulsion a vinyl chloride resin emulsion
  • copolymer resin emulsion of vinyl chloride acrylic acid ester, vinyl acetate, etc.
  • VINIBRAN registered trademark, Nissin
  • urethane emulsion examples include Superflex (registered trademark, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), Adekabon Titer (registered trademark) HUX (manufactured by ADEKA Corporation), and the like.
  • the allergen-reducing composition can be made into a preparation suitable for processing so that the processing can be easily performed.
  • preparations include water-soluble agents dissolved in water or water-soluble solvents, oils or emulsions made highly soluble in water-insoluble agents, and powders and granules held on a suitable carrier.
  • water-soluble agents dissolved in water or water-soluble solvents are preferable.
  • the allergen-reducing composition of the present invention when applied as a spray, it is suitable to be a water-based solution, and a zinc salt and a rare earth salt are added in an amount of 0.01 to 20% as a total of active ingredients,
  • the content is preferably 0.1% to 5.0%, and more preferably 0.1 to 2%.
  • the glycol ether is contained in the range of 0.01 to 25%, preferably 0.1% to 5%, more preferably 0.1 to 1%.
  • a volatile organic solvent it is also possible to add a volatile organic solvent.
  • Ethanol is mentioned as a highly volatile solvent which does not have a safety problem.
  • a fixing agent so that a film is formed when the sprayed liquid dries.
  • a sticking agent Polyethylene glycol is mentioned, 500 or more are preferable as molecular weight of polyethyleneglycol, Furthermore, 6000 or more are more preferable.
  • flavor, a deodorizing component, an antibacterial component, etc. can also be added to a spray agent as other components.
  • the above-mentioned spray can be applied to living spaces such as indoors, spaces in vehicles such as cars and trains, and reduces various allergens such as mites and pollen that are present by adhering or floating in the space. It becomes possible to do.
  • a surfactant can be added for the purpose of improving stability.
  • the surfactant is not particularly limited, and examples thereof include a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant.
  • the type of nonionic surfactant is not particularly limited.
  • polyoxyethylene alkyl phenyl ether, polyoxyethylene styryl phenyl ether, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, sorbitan fatty acid ester examples thereof include oxyethylene sorbitan fatty acid esters.
  • anionic surfactant examples include alkyl benzene sulfonate, polyoxyethylene alkyl phenyl ether sulfate, and dialkyl sulfosuccinate.
  • Cationic surfactants include aliphatic amine salts and quaternary ammonium salts thereof, and amphoteric surfactants include betaine surfactants and aminocarboxylates. These nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants may be used alone or in combination of two or more.
  • the allergen-reducing composition of the present invention may further contain a known allergen-reducing component as long as the physical properties are not impaired.
  • allergen-reducing components include hydroxybenzoic acid compounds such as dihydroxybenzoic acid and 2,4,6-trihydroxybenzoic acid or salts thereof, polystyrene compounds such as parahydroxypolystyrene and polystyrenesulfonate, Examples include extracts, inorganic salt compounds such as calcium salts and strontium salts.
  • the allergen-reducing composition of the present invention When the allergen-reducing composition of the present invention is used for the purpose of removing allergens from indoor dust mites, the allergen-reducing effect can be further maintained by processing it simultaneously with an acaricide.
  • the acaricide used is not particularly limited as long as it has a lethal and repellent effect on indoor dust mites.
  • benzyl alcohol benzyl benzoate, phenyl salicylate, cinnamaldehyde, hyssop oil, carrot seed oil
  • pyrethroid compounds such as natural pyrethrin, phenothrin, and permethrin
  • organophosphorus compounds such as fenitrothion, malathion, fenthion, and diazinon, dicofol, chlorbenzilate, hexythiazox, tebufenpyrad, pyridaben, and amidoflumet are used. be able to.
  • the allergen-reducing composition of the present invention may be concerned about mold or fungus growth. Therefore, it is possible to use a fungicide or an antibacterial agent at the same time.
  • the type of antifungal agent or antibacterial agent is not particularly limited as long as it has an antifungal or antibacterial effect.
  • the allergen-reducing composition of the present invention in addition to the aforementioned surfactant, anti-mite agent and antibacterial agent, if necessary, chelating agent, anti-rust agent, perfume, scale inhibitor, antifoaming agent It is also possible to add an antistatic agent, a resin binder, a thickener, a softening agent, and the like.
  • Examples of usage forms of the allergen-reducing composition of the present invention include spraying agents and processing agents, but compositions that may come into contact with people in the environment, such as softeners, deodorants, fungicides, It is also possible to reduce allergens in the environment by adding them to disinfectants, insecticides, paints, adhesives, etc., and materials that can come into contact with people in the environment, such as wood, concrete, metal It is also possible to reduce allergens in the environment by processing into building materials such as stone and glass, molded products made of rubber, paper, resin and plastic.
  • Neodymium Lactate Aqueous Solution In a 100 mL Erlenmeyer flask equipped with a ball cooling tube, 10.4 g of 90% lactic acid and 29.4 g of ion-exchanged water were mixed, and 4.2 g of neodymium oxide was further added. The mixture was heated to 75 ° C. in a hot water bath and stirred for 1 hour, and then 1 drop of sulfuric acid was added. Stirring was further continued for 1 hour to dissolve neodymium oxide. After cooling, it was taken out and the total amount was diluted to 120 g using ion-exchanged water to obtain a purple aqueous solution containing about 4% neodymium lactate.
  • Examples 1 to 22 were prepared with the formulations shown in Tables 1 to 3, and Comparative Examples 1 to 42 were prepared with the formulations shown in Tables 4 to 9.
  • Test Example 1 Measurement of the mite allergen reducing effect of the allergen-reducing composition
  • the allergen solution containing mite allergen Der f2 and having a protein amount of about 900 ng / 1 mL ⁇ phosphate buffer (pH 7.2) ⁇ Examples 1 to 22 and Comparative Examples 1 to 42 were each reacted with 25 ⁇ L.
  • the mite allergen reduction effect was measured by the sandwich method of Der f2 enzyme immunoassay (ELISA).
  • Peroxidase-labeled anti-Der f2 monoclonal antibody was dissolved in phosphate buffer ⁇ pH 7.2, containing 1% by weight bovine serum albumin and 0.05% by weight polyoxyethylene (20) sorbitan monolaurate ⁇ at 200 ⁇ g / mL, A solution obtained by diluting it with phosphate buffer (pH 7.2, containing 1% by weight bovine serum albumin and 0.05% by weight polyoxyethylene (20) sorbitan monolaurate) 1200 times was added at 100 ⁇ L per well. . After reacting at 37 ° C. for 60 minutes, the plate was washed with a phosphate buffer (pH 7.2).
  • Test Example 2 Measurement of reduction effect of cedar pollen allergen by allergen-reducing composition Example 1, 7, against allergen solution of about 12.5 ng / 1 mL ⁇ phosphate buffer solution (pH 7.2) ⁇ as cedar pollen allergen Cry j1 8, 10, 11, 12, 14, 15, 16, 18, 19, 22, Comparative Examples 1, 7, 8, 10, 11, 14, 22, 23, 39, 40, 41, 42, 25 ⁇ L each Reacted. These samples were measured for the effect of reducing cedar pollen allergen by the sandwich method of Cry j1 enzyme immunoassay (ELISA).
  • ELISA enzyme immunoassay
  • Cry j1 monoclonal antibody 013 diluted to 2 ⁇ g / mL with phosphate buffer (pH 7.4, containing 0.1 wt% NaN 3 ) was added per well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 100 ⁇ L each was added and sensitized at 4 ° C. for 1 day or longer. After sensitization, the solution was discarded, and a blocking reagent ⁇ 1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 ) ⁇ was added in an amount of 200 ⁇ L per well. Reacted for 1 minute. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate).
  • phosphate buffer pH 7.4, containing 0.1 wt% NaN 3
  • Peroxidase-labeled Cry j1 monoclonal antibody 053 was dissolved in distilled water to 200 ⁇ g / mL, and then dissolved in phosphate buffer ⁇ pH 7.2, 1 wt% bovine serum albumin and 0.1 wt% polyoxyethylene (20) sorbitan mono A solution diluted 1200 times with laurate contained ⁇ was added at 100 ⁇ L per well. After reacting at 37 ° C. for 60 minutes, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate).
  • Example 3 As shown in Table 14, a 2% zinc gluconate aqueous solution (Comparative Example 10) and a 2% lanthanum chloride heptahydrate aqueous solution (Comparative Example 1) had a ratio of 1: 9, 3: 7, 7: 3, and 9: 1. These were mixed at a ratio to give Examples 23 to 26, respectively. In addition, what was mixed by the ratio of 5: 5 (Example 1) was described. About these Examples, the reduction effect of mite allergen Der f2 was measured by the same method as in Test Example 1. The results are shown in Table 14.
  • PVC sheet As a PVC wallpaper surface layer, 100 g of polyvinyl chloride powder having an average degree of polymerization of 700 (PQB83, Shin-Daiichi PVC Co., Ltd.), 50 g of plasticizer diisononyl phthalate (DINP, manufactured by Taoka Chemical Co., Ltd.), ADK STAB as a stabilizer (Registered trademark) FL100 (manufactured by ADEKA Corporation) 3 g and isoparaffin (IP Solvent 2028, manufactured by Idemitsu Kosan Co., Ltd.) 7 g were mixed using a stirrer. The prepared surface layer solution was applied to an A4 size PPC paper as a base material layer so as to be about 200 g / m 2 and heated at 150 ° C. for 1 minute to obtain a PVC wallpaper.
  • PQB83 Shin-Daiichi PVC Co., Ltd.
  • DINP plasticizer diisononyl phthalate
  • ADK STAB as
  • Example 5 Using urethane-based resin emulsion (Superflex 500M (registered trademark), manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) as the surface treatment agent, 12% each of Example 31, Comparative Example 43, and Comparative Example 44 were added thereto. Mixed. This surface treatment agent was applied to the polyvinyl chloride sheet so as to be 10 g / m 2 and dried at room temperature to obtain an allergen-reduced wallpaper.
  • Superflex 500M registered trademark
  • Comparative Example 44 Comparative Example 44
  • Example 32 Dissolve 0.8 g of zinc gluconate, 0.4 g of lanthanum chloride heptahydrate, 0.8 g of polyethylene glycol (molecular weight 20000) and 0.9 g of ethylene glycol monophenyl ether (manufactured by Nippon Emulsifier Co., Ltd.) in ion-exchanged water. A total amount of 100 g was used as a propellant.
  • Example 33 0.8 g of zinc gluconate, 0.4 g of lanthanum chloride heptahydrate and 0.8 g of polyethylene glycol (molecular weight 20000) were dissolved in ion-exchanged water to make a total amount of 100 g as a spray.
  • Example 6 Measurement of allergen reduction effect by propellant
  • Example 32, Example 33, Comparative Example 45, and Comparative Example 46 was placed in a trigger spray container, and about 20 g was sprayed on 0.5 m 2 of floor carpet in the office.
  • a fine dust collecting device “garbage collection bag” manufactured by Sumika Environmental Science Co., Ltd.
  • Hitachi PV-H23: suction work rate 240 W was attached to the suction hose of a vacuum cleaner (Hitachi PV-H23: suction work rate 240 W).
  • the portion sprayed with 33 or Comparative Examples 45 and 46 and the portion not sprayed (control) were each sucked and collected from an area of 0.5 m 2 for 1 minute.
  • the garbage collection bag from which the garbage was collected was put into a vinyl bag with a chuck, and mite allergen was extracted with 5 mL of phosphate buffer. Using the extract as a measurement sample of the mite allergen amount, the mite allergen amount was measured using the same method as in [Test Example 1] by the sandwich method of Der f2 enzyme immunoassay (ELISA). The results are shown in Table 17.
  • Spray Stability Test Example 32, Example 33, Comparative Example 45, and Comparative Example 46 were each placed in a polyethylene trigger spray container, stored in a thermostatic chamber at 25 ° C., and the appearance was observed. It was. The results are shown in Table 18.
  • allergens such as mites and pollen can be reduced, and the nonwoven fabric, fiber or fiber product can be produced without causing coloring.

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JP2017057194A (ja) * 2015-09-17 2017-03-23 住化エンバイロメンタルサイエンス株式会社 アレルゲン低減化および抗菌組成物
JP2018012799A (ja) * 2016-07-22 2018-01-25 住化エンバイロメンタルサイエンス株式会社 アレルゲン低減化組成物

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Publication number Priority date Publication date Assignee Title
JP2006183045A (ja) * 2004-11-30 2006-07-13 Lion Corp 銀系化合物含有ハウスダスト処理剤
JP2010121145A (ja) * 2008-11-17 2010-06-03 Toyo Seikan Kaisha Ltd 金属超微粒子形成用脂肪酸金属塩
WO2015141713A1 (ja) * 2014-03-20 2015-09-24 住化エンバイロメンタルサイエンス株式会社 アレルゲン低減化組成物、それを含む噴霧剤と表面加工剤、アレルゲン低減化方法、アレルゲン低減化された繊維構造体と建築用内装材
JP2017057194A (ja) * 2015-09-17 2017-03-23 住化エンバイロメンタルサイエンス株式会社 アレルゲン低減化および抗菌組成物
JP2018012799A (ja) * 2016-07-22 2018-01-25 住化エンバイロメンタルサイエンス株式会社 アレルゲン低減化組成物

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