WO2017050665A1 - Plaquettes monoalvéolaires pour un empilement optimisé - Google Patents

Plaquettes monoalvéolaires pour un empilement optimisé Download PDF

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Publication number
WO2017050665A1
WO2017050665A1 PCT/EP2016/072094 EP2016072094W WO2017050665A1 WO 2017050665 A1 WO2017050665 A1 WO 2017050665A1 EP 2016072094 W EP2016072094 W EP 2016072094W WO 2017050665 A1 WO2017050665 A1 WO 2017050665A1
Authority
WO
WIPO (PCT)
Prior art keywords
blister
einzelblister
bladder
height
bubble
Prior art date
Application number
PCT/EP2016/072094
Other languages
German (de)
English (en)
Inventor
Stefan Bracht
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CR20180179A priority Critical patent/CR20180179A/es
Priority to CN201680054965.6A priority patent/CN108025847B/zh
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Priority to JP2018515063A priority patent/JP2018527262A/ja
Priority to EP16766968.8A priority patent/EP3353086A1/fr
Priority to MX2018003577A priority patent/MX2018003577A/es
Priority to AU2016328423A priority patent/AU2016328423A1/en
Priority to KR1020187011040A priority patent/KR20180054790A/ko
Priority to EA201890798A priority patent/EA201890798A1/ru
Priority to SG11201802095WA priority patent/SG11201802095WA/en
Priority to CA2999102A priority patent/CA2999102A1/fr
Priority to US15/761,737 priority patent/US20180282040A1/en
Publication of WO2017050665A1 publication Critical patent/WO2017050665A1/fr
Priority to IL258028A priority patent/IL258028A/en
Priority to PH12018500593A priority patent/PH12018500593A1/en
Priority to CONC2018/0003056A priority patent/CO2018003056A2/es
Priority to HK18109791.2A priority patent/HK1250363A1/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/326—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming one compartment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/366—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming one compartment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
    • B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3263—Means or construction allowing stacking, bundling or interfitting of packages

Definitions

  • the present invention relates to single blister packs, methods for their production, stapeiförmige arrangements containing such Einzelblisterpackonne and boxes containing stapeiförmige arrangements of Einzelblisterpackonne.
  • Blister packs have long been known. Medicament portions such as tablets and capsules are preferably delivered in blister packs as primary packaging. In a blister pack, the tablets or capsules are in an arrangement of individual wells (bubbles) in a plastic or aluminum foil. The recesses are usually sealed by an aluminum foil. The medicine portions can be removed individually and are protected against dirt and humidity. Another advantage of drug portions in blister packs is the easy recognition of the remaining number of available drug portions.
  • FIG. 1a of published patent application GB2184086A 15 individual drug portions are present in an areal arrangement of approximately 6-8 cm ⁇ 4-6 cm.
  • blister packs are placed in another package prior to delivery to the patient.
  • This secondary packaging is typically a folding box which, in addition to a number of approximately 1 to 10 blister packs, usually also contains a package insert with usage and safety information.
  • the secondary packaging prevents slippage of stacked blister packs. It is essentially only needed for transport and falls to the consumer as waste. Due to the bulky and voluminous bubble structure of conventional blister packs, the secondary packaging is comparatively bulky.
  • a blister pack which in addition to the wells for receiving drug portions has additional centering nubs that extend beyond the bottom of the wells.
  • the blister pack on supporting knobs, which also protrude beyond the underside of the wells.
  • the cover sheet has perforations in the area around each one Zentriernoppe, so that in a flush stacking of the blister packs each Zentriernoppe a blister strip rests on a perforation of the underlying blister strip.
  • the support nubs lie on the cover sheet of the underlying blister strip, so that the blister strips are supported against each other. Since the so stacked blister packs can not slip against each other, can be dispensed with an elaborate outer packaging or can be very easily formed. The disadvantage, however, is that no volume reduction in the overpack compared to a stack of analog blister strips without Zentriernoppen results by the stacking described. Furthermore, a single blister strip can not be easily removed from the outer packaging; he must first be released from the stack, which is possible only in one direction.
  • DE 19680564 Tl discloses a foldable blister strip. It has two parallel rows of bubbles that are offset from each other so that the bubbles of one row engage in the spaces between the bubbles of the other row as the blister strip folds. As a result, the folded blister strip takes up less space than if the rows of blisters were stacked in a conventional manner. For use, however, the folded blister strip of the outer packaging must first be removed and unfolded, which is relatively cumbersome.
  • a similar foldable blister pack is also disclosed in DE 29780456 U l.
  • the blister packs described so far contain more than one portion of medication.
  • a patient only takes a single drug portion at the time of taking it. If, for example, the patient has to take a portion of medication every day, he will gradually empty the blister pack by taking a single dose of medication each day.
  • a patient carries a blister strip containing several drug portions with him, for example, to have a portion of medicines ready when needed and / or to be reminded of a regular intake.
  • more drug portions are carried along than are actually needed. There is a risk that the blister strip will be lost or damaged, and that individual portions of the medication will be lost, broken, become wet, or otherwise rendered unusable.
  • medicament portions it is also common in some establishments for medicament portions to be removed from blister packs and stored in day or weekend boxes / boxes where they are exposed to light and moisture (especially when storing the rations in the bath). In this respect, it would be advantageous if the drug portions remained packed until shortly before their ingestion by the patient in a blister containing the necessary labeling in order to identify the content clearly.
  • blister strips which have perforations in order to separate individual bubbles with drug portions can (see, for example, EP 679587 AI). This makes it possible to carry only the amount of drug portions that is actually needed. It is thus also possible to transfer packaged medicament portions to a patient in a hospital or a resident in a nursing home.
  • these blister units do not have the complete information about the contents, since usually the label on the back side of a blister strip is destroyed or dismembered by separating individual blister units.
  • the cover sheet may tear.
  • the separation of individual units often creates sharp corners and edges where they can be injured or caused by damage to materials, e.g. when blister packs or remnants of blister packs are kept in bags or coats without being repackaged.
  • blister strips with a fixed number of multiple drug portions limit the flexibility. For example, if a blister strip contains 10 portions of medication, only packs of this number or a multiple thereof (20, 30, ...) can be offered.
  • One problem underlying the present invention is therefore to provide packaged medicament portions which allow a greater degree of flexibility and security in provision and handling while saving space and conserving resources.
  • a first subject of the invention is a stacked arrangement of N single blister packs, where N is an integer greater than 1,
  • the height hs of the stack-like arrangement is less than / V times the sum of the height h B of a bubble, the thickness de of a flat body and the thickness d D of a cover sheet:
  • a medication portion is understood to be a solid dosage form of a drug that can be taken by a patient as a single unit.
  • medicament portions are tablets, pills, dragees and capsules.
  • a single blister pack is understood as meaning a combination of a single blister pack and one or more drug portions.
  • One or more drug portions are packaged in the individual blister pack and form with this single blister pack a single blister pack containing one or more drug portions or short a single blister.
  • the term "single” refers to the number of bubbles, so a single blister is a unit having a single bladder Synonymous terms used in the art instead of the term bladder are, for example, well and well.
  • the Einzelblisterverpackung comprises a flat body.
  • the flat body usually consists of a film layer.
  • Another film layer - here called cover film - is used to seal the bubble.
  • a flat body is understood to mean a body which has a greater extent in two of the three spatial directions in a Cartesian coordinate system than in the third spatial direction. If one thinks of the bubble away and one assumes that the main body has no curvature, then the expansion in the third spatial direction (z-direction, thickness of the film layer) is only a fraction of the expansion in the other two spatial directions (x and y - Direction).
  • the thickness of the film layer de is preferably less than one-tenth of the expansion in the thickness perpendicular orthogonal spatial directions (x and y direction), more preferably less than a twentieth.
  • the flat body preferably has no or only a slight curvature.
  • the radius of curvature is at least 10 times the extent in the x and / or y direction. In a particularly preferred embodiment, the radius of curvature is at least 20 times the extent in the x and / or y direction. In a very particularly preferred embodiment, the radius of curvature is at least 50 times the extent in the x and / or y direction.
  • the flat basic body always has a certain curvature, even if the aim is to make the basic body (with the exception of the bladder) as flat as possible.
  • the introduction of the bladder into the body which is usually done by thermoforming, can cause stresses in the body that lead to a curvature.
  • the mechanical processing such as printing, cutting, gripping (e.g., during transportation), etc., bends may be introduced into the main body.
  • the application of the cover sheet represents a mechanical stress, which can lead to deformation.
  • an ideal, non-curved base body is assumed. However, this is done only to better illustrate the invention and should not be construed as limiting the invention.
  • the flat body can take many forms. It may assume a circular, oval, triangular, quadrangular (e.g., rectangular or square), pentagonal, hexagonal, and other basic shapes in the xy plane, the corners each being rounded.
  • the planar body has a square, rectangular or angular basic shape in the xy plane, but the corners may be rounded.
  • the term "angular” is explained in more detail below.
  • the corners of the flat body are rounded to avoid injury to the persons handling the individual blisters and / or damage to materials with which the Einzelblister come into contact.
  • the base body must be at least so large that a blister for receiving a drug portion can be introduced and the bladder can be closed with a cover foil.
  • a typical size is, for example, an extension in the x and y directions from 0.6 cm to 6 cm and in the z direction from 0.2 mm to 2 mm.
  • the main body can also be made larger or smaller.
  • information about the drug in the bladder is applied to the cover sheet.
  • information about the drug in the bladder may e.g. the name of the active substance, the name of the manufacturer and / or distributor, a lot number (Ch.B.), the expiry date, a dosage and other information.
  • Some information is required by authorities supervising the placing on the market of medicinal products, other information may be useful for the people involved in the packaged medicine, such as patients, doctors, nurses, transport and logistics companies, packers and others.
  • targeted colors may be used; conceivable is e.g. a red color for taking in the morning and a blue color for taking in the evening / night.
  • the ventral side is the side on which the bladder protrudes from the main body and which is opposite to the side on which the cover film is applied.
  • the main body therefore has a minimum size which allows at least the information required by the authorities to be applied to the base body and / or the cover film.
  • a certain minimum size also offers the advantages that the single blister is not lost so quickly, and that it is easier to handle and open especially for the elderly.
  • information can also be incorporated, for example, as an engraving in the base body and / or the cover sheet.
  • the bubble is introduced into the base body. It usually serves to receive a single portion of medication. But it is also conceivable that there are several drug portions in a bladder. For example, it is conceivable that the amount of drug a patient must take at a given time is too large for a single dose of medication because of problems with ingestion. Therefore, it may be appropriate to distribute the drug to several, smaller drug portions.
  • the bladder contains a maximum of four drug portions; most preferably it contains a single drug portion.
  • the bladder may be centrally or decentrally incorporated in the body.
  • central and “decentralized” are explained in more detail below.
  • the cover film is applied to the so-called back side of the body and closes the bladder, which protrudes on the opposite side of the stomach from the body.
  • FIG. 1 clarifies this.
  • FIG 1 shows an example of a single blister 1 in the plan view and from two sides.
  • the Einzelblister 1 comprises a flat body 2, in which a bubble 3 is introduced.
  • the bladder 3 is a single drug portion (not shown in Figure 1).
  • the bladder is closed by a cover sheet 4.
  • the bladder 3 is centrally introduced in the flat body 2.
  • the basic shape of the body is rectangular - with rounded corners.
  • the cover sheet usually does not necessarily extend over the entire back side of the main body and ends flush with the edges of the main body.
  • the cover film preferably also has the basic shape of the base body and is ideally designed flat (without curvature).
  • the cover films are preferably in planes which run parallel to one another.
  • N is an integer in the range of 2 to 31. In another preferred embodiment, N is 7. In another preferred embodiment, N is equal to 28.
  • the bubbles preferably point in the same direction.
  • the Einzelblister are each arranged alternately back side to back side and stomach side on the stomach side. Mixed forms between the mentioned stack shapes are also conceivable.
  • the height hs of the stacked configuration is / V times the sum of the height h B of a bubble, the thickness de of a planar body, and the thickness d D of a cover sheet :
  • the stack height In a particularly preferred embodiment, the following applies for the stack height:
  • the individual blisters are stacked so that the cover sheet of a single blister is applied to the body of an adjacent single blister in an area adjacent to the bladder.
  • FIG. 3 illustrates this embodiment.
  • FIG. 3 shows an example of an arrangement according to the invention in the top view (bottom) and from one side (top). Seven copies (1-1, 1-2, 1-3, 1-4, 1-5, 1-6, 1-7) of the single blister 1 of FIG. 1 are stacked arranged one above the other. All bubbles point in the same direction.
  • the single blister 1-1 is arranged in the stack at the bottom.
  • the Einzelblister 1-2 is on the single blister 1-1.
  • the cover sheet of the single blister 1-2 is applied to the main body of the adjacent single blister 1-1, in an area adjacent to the bladder.
  • For the Einzelblister 1-7 is indicated which side of the stomach side B and which side represents the back side R.
  • the abdominal side B is therefore the side on which the bladder 3 protrudes from the main body 2.
  • the back R is the side on which cover sheet 4 is applied, which closes the bladder 3.
  • F E is the surface area of a single single blister in the projection on the plane that is parallel to the basic shape of the flat main body (xy plane) and Fo is the overlap area of two adjacent blister blanks in the same projection plane.
  • the space requirement of a stackable arrangement according to the invention is less than the area required for adjacent individual blisters, since the individual blisters of the stacked arrangement overlap in the xy projection plane.
  • Fo el is preferably from 0.3 to 1, particularly preferably from 0.5 to first
  • the size of the relative overlap area can be maximized in several ways, e.g. by a decentralized arrangement of the bubbles and / or by recesses in the base body, as will be explained in more detail below.
  • the bubbles of the individual blisters are arranged in a decentralized manner relative to the basic shape of the flat main body.
  • the center of the basic form of the planar basic body is determined either by its center of symmetry or, if the basic form has no center of symmetry, by the center of gravity of the basic form.
  • the bladder also has a center which is determined either by the center of symmetry or, if the bladder has no center of symmetry, by the center of gravity of the bladder.
  • a decentralized arrangement of the bladder means an arrangement in which the center of the bladder does not coincide with the center of the basic shape of the flat main body.
  • FIG. 4 shows an example of a single blister 1 in plan view and from two sides.
  • the single blister 1 comprises a flat base body 2, in which a bubble 3 is introduced.
  • the bladder 3 is a single drug portion (not shown in Figure 4).
  • the bladder is closed by a cover sheet 4.
  • the bladder 3 is introduced decentrally in the flat body 2.
  • the basic shape of the body is rectangular - with rounded corners.
  • FIG. 5 shows an example of an arrangement according to the invention in the top view (bottom) and from one side (top). Seven copies (1-1, 1-2, 1-3, 1-4, 1-5, 1-6, 1-7) of the single blister 1 of Fig. 4 are stacked arranged one above the other. All bubbles are pointing in the same direction.
  • each individual blister has a recess within which the bladder of an adjacent single blister can be placed. This also results in a denser packing both in the stacking direction and perpendicular thereto.
  • Figures 6 and 7 illustrate this embodiment.
  • the edges of the basic shape have a convex contour, for example, have a circular, a square and a rectangular If, on the other hand, for example, a half-round recess is punched out in the edge region of a square basic shape, the contour of the basic shape is no longer convex at all points but concave in the region of the recess.
  • base areas with recess are to be understood as meaning all base areas in which the contour also comprises at least one concave area in addition to convex areas.
  • the recess is preferably round, semicircular, elliptical, semi-elliptical or rectangular.
  • FIG. 6 shows an example.
  • Both each have a flat body 2, in which a blister 3 is incorporated for receiving a drug portion.
  • the bladder is decentralized with respect to the body.
  • Both main body have a semi-circular recess 5.
  • FIG. 7 shows how in each case two of the individual blisters 1 and alternately stackable are arranged one above the other.
  • each individual blister on support structures.
  • the support structures may be incorporated as the bladder in the body. It is also conceivable that the support structures are applied to the base body. According to the invention, the support structures have a lower height than the bubble: h N ⁇ h B.
  • FIG. 8 shows an example.
  • a bubble 3 is disposed decentrally.
  • a circular recess 5 is introduced, in which a bubble of a further single blister can be placed in a stapeiförmigen arrangement.
  • the base body also has support structures in the form of two support knobs 7, whose height h N is less than the height of the bubble h B.
  • FIG. 9 two of the individual blisters from FIG. 8 are stacked one above the other.
  • the lower Einzelblister is rotated relative to the upper Einzelblister by 180 °, so that the bubble of the lower single blister falls exactly into the recess of the upper single blister.
  • the main body of the upper single blister abuts the supporting knobs of the lower single blister.
  • a special form of "base with recess” is the angular base, which is a particularly preferred embodiment
  • the recess is rectangular
  • An example of an angular base is shown in Fig. 10.
  • An angular base is understood to mean a surface in which two surface elements
  • the blister of a single blister falls within the free area between the surface elements of the base of an adjacent single blister extending surface elements enclose an angle of less than 180 °, preferably the angle is in the range of 120 ° to 60 °, more preferably in the range of 100 ° to 80 °, most preferably b If the angle is 90 °, the surface elements running in different directions are preferably of the same shape; preferably they are rectangular.
  • FIG. 10 shows a single blister with an angular basic body.
  • the main body 2 comprises two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and delimit a free area in which the bladder of a further single blister can be placed in a stapeiförmigen arrangement.
  • the main body 2 has support structures in the form of supporting knobs 7, whose height h N is less than the height h B of the bubble 3.
  • Figure 11 shows in a plan view (bottom) and in a side view (open), as two of the individual blister from FIG 10 are stacked on top of each other.
  • the bladder of each individual blister of a stack according to the invention is arranged decentrally with respect to the basic shape of the base body and the base body also has a recess in which the bladder of an adjacent single blister can be placed.
  • Figures 12 and 13 illustrate this embodiment.
  • a single blister 1 is shown
  • the base body 2 has two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and define a free area in which the bladder of another single blister are placed in a stapeiförmigen arrangement can.
  • the base body 2 also has support structures in the form of a support web 8.
  • FIG. 13 shows how three of the individual blisters from FIG. 12 are stacked on top of one another in a helical manner.
  • Figures 14, 15, 16 and 17 show further embodiments of the present invention in which the medicament portion and, accordingly, the bladder have an elongate shape.
  • a single window 1 is shown, the main body 2 has two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and delimit a free area in which the bladder of another single blister are placed in a stapeiförmigen arrangement can.
  • the surface elements 6 and 6 ' have a different size.
  • FIG. 15 three of the individual blisters from FIG. 15 are stacked on top of each other.
  • FIG. 16 shows a single blister 1 in whose main body 2 a bladder 3 is arranged in a decentralized manner.
  • a recess 5 is introduced, in which a bubble of a further single blister can be placed in a stapeiförmigen arrangement.
  • the main body also has support structures in the form of four support knobs 7, whose height h N is less than the height of the bubble h B.
  • FIG. 17 two of the individual blisters from FIG. 16 are stacked one above the other.
  • the lower Einzelblister is rotated relative to the upper Einzelblister by 180 °, so that the bubble of the lower single blister falls exactly into the recess of the upper single blister.
  • the main body of the upper single blister abuts the supporting knobs of the lower single blister.
  • Another object of the present invention is a box containing a stapeiförmige arrangement of individual blisters according to the invention.
  • the box serves as secondary packaging. It usually also includes a leaflet with information about taking the medicine portions.
  • the box serves to stabilize the stack-shaped arrangement according to the invention. It consists for example of cardboard, plastic, metal or a composite material.
  • the box is a carton carton, as used for conventional blister strips.
  • the box contains a viewing window, via which the remaining amount of the individual blisters present in the box can be determined.
  • the box has a lateral opening in the lower area of the box, over which a single blister of the box can be removed. Due to gravity, the remaining in the box Einzelblister slip upon removal of the lower single blister and can be removed one after another until the box is emptied.
  • FIG. 18 shows three boxes according to the invention. The right contains seven, the middle fourteen and the left 28 Einzelblister. The left box has a viewing window on the side over which the remaining number of individual blisters can be determined. The left box also has an opening in the lower area, over which the individual blisters can be removed laterally.
  • Another object of the present invention are individual blisters, which are particularly designed to allow a stacking according to the invention.
  • the individual blisters are characterized in that the bladder is arranged decentrally with respect to the base body. Particularly preferred embodiments are shown in FIGS. 4, 6, 8, 12, 14 and 16.
  • the individual blisters have a recess in which the bladder of an adjacent single blister can be placed in a stackable arrangement according to the invention. Particularly preferred embodiments are shown in FIGS. 6, 8, 10, 12, 14 and 16.
  • the basic body of the individual blister according to the invention has a rectangular or square basic shape, in which the corners are optionally rounded. Particularly preferred embodiments are shown in FIGS. 4, 6, 8 and 16.
  • the main body of the individual blister according to the invention has an angular basic shape, in which the corners are optionally rounded. Particularly preferred embodiments are shown in FIGS. 10, 12 and 14.
  • the Einzelblister exists in two different copies, which behave to each other as image and mirror image.
  • a particularly preferred embodiment is shown in FIG.
  • the flat basic body has one or more basic shapes which, apart from optionally rounded corners, allow tiling of a rectangular area.
  • Tiling also referred to as tiling, paving, or surface finish
  • Tiling is understood to mean the gapless and overlapping-free covering of a surface by means of uniform partial surfaces.
  • the basic forms of the flat basic body form the partial surfaces.
  • the advantage of the tiling is that the main body can be obtained by dividing a larger blister sheet, whereby fragmentation residues (cut remnants, waste) are reduced to a minimum.
  • the Einzelblister shown in Figures 1, 4, 8, 10, 12, 14 and 16 allow a tiling.
  • Another object of the present invention is a process for the preparation of Einzelblister invention.
  • the method according to the invention is characterized in that the individual blisters are separated from a sheet or web comprising a plurality of individual blisters.
  • the separation can be carried out by conventional methods such as laser cutting, mechanical cutting, stamping, etching, electron beam machining, ultrasound and water jet. These and other methods are e.g. described in DIN standards 8588, 8589 and 8590.
  • the individual blisters are produced from a macroblister, which is described in more detail in EP15182316.8.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Auxiliary Apparatuses For Manual Packaging Operations (AREA)
  • Stackable Containers (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)

Abstract

La présente invention concerne des plaquettes monoalvéolaires, des procédés de fabrication desdites plaquettes, des groupes en forme de piles contenant lesdites plaquettes monoalvéolaires, et des boîtes contenant des groupes en forme de piles de plaquettes monoalvéolaires.
PCT/EP2016/072094 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé WO2017050665A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SG11201802095WA SG11201802095WA (en) 2015-09-22 2016-09-19 Individual blister pack for optimized stacking
EA201890798A EA201890798A1 (ru) 2015-09-22 2016-09-19 Единичные блистерные пачки для оптимизированного пакетирования
JP2018515063A JP2018527262A (ja) 2015-09-22 2016-09-19 最適化されたスタックのための個別ブリスターパック
CN201680054965.6A CN108025847B (zh) 2015-09-22 2016-09-19 用于优化堆叠的个体泡罩包装件
MX2018003577A MX2018003577A (es) 2015-09-22 2016-09-19 Blisters individuales para apilamiento optimizado.
AU2016328423A AU2016328423A1 (en) 2015-09-22 2016-09-19 Individual blister pack for optimized stacking
CA2999102A CA2999102A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalveolaires pour un empilement optimise
CR20180179A CR20180179A (es) 2015-09-22 2016-09-19 Blísters individuales para apilamiento optimizado
EP16766968.8A EP3353086A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé
KR1020187011040A KR20180054790A (ko) 2015-09-22 2016-09-19 최적화된 적층을 위한 개별 블리스터 팩
US15/761,737 US20180282040A1 (en) 2015-09-22 2016-09-19 Individual blister packs for optimized stacking
IL258028A IL258028A (en) 2015-09-22 2018-03-12 Individual blister pack for optimized stacking
PH12018500593A PH12018500593A1 (en) 2015-09-22 2018-03-19 Individual blister pack for optimized stacking
CONC2018/0003056A CO2018003056A2 (es) 2015-09-22 2018-03-22 Blísters individuales para apilamiento optimizado
HK18109791.2A HK1250363A1 (zh) 2015-09-22 2018-07-30 用於優化堆叠的個體泡罩包裝件

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186159.8A EP3147233A1 (fr) 2015-09-22 2015-09-22 Emballage transparent individuel destine a etre empile de maniere optimale
EP15186159.8 2015-09-22

Publications (1)

Publication Number Publication Date
WO2017050665A1 true WO2017050665A1 (fr) 2017-03-30

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PCT/EP2016/072094 WO2017050665A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé

Country Status (20)

Country Link
US (1) US20180282040A1 (fr)
EP (2) EP3147233A1 (fr)
JP (1) JP2018527262A (fr)
KR (1) KR20180054790A (fr)
CN (1) CN108025847B (fr)
AU (1) AU2016328423A1 (fr)
CA (1) CA2999102A1 (fr)
CL (1) CL2018000758A1 (fr)
CO (1) CO2018003056A2 (fr)
CR (1) CR20180179A (fr)
EA (1) EA201890798A1 (fr)
HK (1) HK1250363A1 (fr)
IL (1) IL258028A (fr)
MA (1) MA42916A (fr)
MX (1) MX2018003577A (fr)
PE (1) PE20180644A1 (fr)
PH (1) PH12018500593A1 (fr)
SG (1) SG11201802095WA (fr)
SV (1) SV2018005658A (fr)
WO (1) WO2017050665A1 (fr)

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DK4219336T3 (da) * 2019-11-14 2024-05-21 Perfetti Van Melle Benelux B V Manipulationssikker blisterpakning

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DE4429503A1 (de) * 1994-08-19 1996-02-22 Klaus A Dipl Ing Kreft Packung, insbesondere Arzneimittelpackung, und Verfahren zur Herstellung der Packung
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JP2018527262A (ja) 2018-09-20
HK1250363A1 (zh) 2018-12-14
KR20180054790A (ko) 2018-05-24
PE20180644A1 (es) 2018-04-16
US20180282040A1 (en) 2018-10-04
EA201890798A1 (ru) 2018-10-31
SG11201802095WA (en) 2018-04-27
MX2018003577A (es) 2018-06-19
CO2018003056A2 (es) 2018-06-12
CN108025847B (zh) 2019-12-31
CA2999102A1 (fr) 2017-03-30
CN108025847A (zh) 2018-05-11
PH12018500593A1 (en) 2018-10-01
CL2018000758A1 (es) 2018-08-17
EP3353086A1 (fr) 2018-08-01
MA42916A (fr) 2018-08-01
CR20180179A (es) 2018-05-28
SV2018005658A (es) 2018-10-02
EP3147233A1 (fr) 2017-03-29
IL258028A (en) 2018-05-31
AU2016328423A1 (en) 2018-04-12

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