EP3147233A1 - Emballage transparent individuel destine a etre empile de maniere optimale - Google Patents

Emballage transparent individuel destine a etre empile de maniere optimale Download PDF

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Publication number
EP3147233A1
EP3147233A1 EP15186159.8A EP15186159A EP3147233A1 EP 3147233 A1 EP3147233 A1 EP 3147233A1 EP 15186159 A EP15186159 A EP 15186159A EP 3147233 A1 EP3147233 A1 EP 3147233A1
Authority
EP
European Patent Office
Prior art keywords
blister
einzelblister
stack
bladder
height
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15186159.8A
Other languages
German (de)
English (en)
Inventor
Erfindernennung liegt noch nicht vor Die
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Priority to EP15186159.8A priority Critical patent/EP3147233A1/fr
Priority to KR1020187011040A priority patent/KR20180054790A/ko
Priority to EP16766968.8A priority patent/EP3353086A1/fr
Priority to CR20180179A priority patent/CR20180179A/es
Priority to US15/761,737 priority patent/US20180282040A1/en
Priority to MX2018003577A priority patent/MX2018003577A/es
Priority to SG11201802095WA priority patent/SG11201802095WA/en
Priority to PCT/EP2016/072094 priority patent/WO2017050665A1/fr
Priority to EA201890798A priority patent/EA201890798A1/ru
Priority to JP2018515063A priority patent/JP2018527262A/ja
Priority to AU2016328423A priority patent/AU2016328423A1/en
Priority to CA2999102A priority patent/CA2999102A1/fr
Priority to CN201680054965.6A priority patent/CN108025847B/zh
Priority to PE2018000434A priority patent/PE20180644A1/es
Priority to MA042916A priority patent/MA42916A/fr
Publication of EP3147233A1 publication Critical patent/EP3147233A1/fr
Priority to IL258028A priority patent/IL258028A/en
Priority to PH12018500593A priority patent/PH12018500593A1/en
Priority to SV2018005658A priority patent/SV2018005658A/es
Priority to CONC2018/0003056A priority patent/CO2018003056A2/es
Priority to CL2018000758A priority patent/CL2018000758A1/es
Priority to HK18109791.2A priority patent/HK1250363A1/zh
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/326—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming one compartment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/366—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming one compartment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
    • B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3263—Means or construction allowing stacking, bundling or interfitting of packages

Definitions

  • the present invention relates to single blister packs, processes for their preparation, stacked arrangements containing such individual blister packs and boxes containing stacked arrangements of individual blister packs.
  • Blister packs have long been known. Medicament portions such as tablets and capsules are preferably delivered in blister packs as primary packaging. In a blister pack, the tablets or capsules are in an arrangement of individual wells (bubbles) in a plastic or aluminum foil. The recesses are usually sealed by an aluminum foil. The medicine portions can be removed individually and are protected against dirt and humidity. Another advantage of drug portions in blister packs is the easy recognition of the remaining number of available drug portions.
  • a typical blister pack is shown in Fig. 1a of the disclosure GB2184086A 15 individual drug portions are present in an areal arrangement of approximately 6-8 cm ⁇ 4-6 cm.
  • blister packs are placed in another package prior to delivery to the patient.
  • This secondary packaging is typically a folding box which, in addition to a number of approximately 1 to 10 blister packs, usually also contains a package insert with usage and safety information.
  • the secondary packaging prevents slippage of stacked blister packs. It is essentially only needed for transport and falls to the consumer as waste. Due to the bulky and voluminous bubble structure of conventional blister packs, the secondary packaging is comparatively bulky.
  • a blister pack which, in addition to the wells for receiving drug portions has additional Zentriernoppen that extend beyond the bottom of the wells.
  • the blister pack on supporting knobs, which also protrude beyond the underside of the wells.
  • the cover sheet has perforations in the area around each one Zentriernoppe, so that in a flush stacking of the blister packs each Zentriernoppe a blister strip rests on a perforation of the underlying blister strip.
  • the support nubs lie on the cover sheet of the underlying blister strip, so that the blister strips are supported against each other. Since the so stacked blister packs can not slip against each other, can be dispensed with an elaborate outer packaging or can be very easily formed. The disadvantage, however, is that no volume reduction in the overpack compared to a stack of analog blister strips without Zentriernoppen results by the stacking described. Furthermore, a single blister strip can not be easily removed from the outer packaging; he must first be released from the stack, which is possible only in one direction.
  • DE 19680564 T1 discloses a foldable blister strip. It has two parallel rows of bubbles that are offset from each other so that the bubbles of one row engage in the spaces between the bubbles of the other row as the blister strip folds. As a result, the folded blister strip takes up less space than if the rows of blisters were stacked in a conventional manner. For use, however, the folded blister strip of the outer packaging must first be removed and unfolded, which is relatively cumbersome.
  • a similar foldable blister pack is also in DE 29780456 U1 disclosed.
  • the blister packs described so far contain more than one portion of medication.
  • a patient only takes a single drug portion at the time of taking it. If, for example, the patient has to take a portion of medication every day, he will gradually empty the blister pack by taking a single dose of medication each day.
  • a patient carries a blister strip containing several drug portions with him, for example, to have a portion of medicines ready when needed and / or to be reminded of a regular intake.
  • more drug portions are carried along than are actually needed. There is a risk that the blister strip will be lost or damaged, and that individual portions of the medication will be lost, broken, become wet, or otherwise rendered unusable.
  • blister strips which have perforations to separate individual bubbles with drug portions can (see, for example EP 679587 A1 ). This makes it possible to carry only the amount of drug portions that is actually needed. It is thus also possible to transfer packaged medicament portions to a patient in a hospital or a resident in a nursing home.
  • these blister units do not have the complete information about the contents, since usually the label on the back side of a blister strip is destroyed or dismembered by separating individual blister units.
  • the cover sheet may tear. By separating individual units often also sharp corners and edges, where you can injure yourself, or caused by the damage to materials, such as when blister units or remnants of blister strips are stored without packaging in bags or coats.
  • blister strips with a fixed number of multiple drug portions limit the flexibility. For example, if a blister strip contains 10 portions of medication, only packs of this number or a multiple thereof (20, 30, ...) can be offered.
  • One problem underlying the present invention is therefore to provide packaged medicament portions which allow a greater degree of flexibility and security in provision and handling while saving space and conserving resources.
  • a medication portion is understood to be a solid dosage form of a drug that can be taken by a patient as a single unit.
  • medicament portions are tablets, pills, dragees and capsules.
  • a single blister pack is understood as meaning a combination of a single blister pack and one or more drug portions.
  • One or more drug portions are packaged in the individual blister pack and form with this single blister pack a single blister pack containing one or more drug portions or short a single blister.
  • the term "single” refers to the number of bubbles.
  • a single blister is thus a unit that has a single bladder. Synonymous terms used in the prior art instead of the term bladder are e.g. Cavity and depression.
  • the Einzelblisterverpackung comprises a flat body.
  • the flat body usually consists of a film layer.
  • Another film layer - here called cover film - is used to seal the bubble.
  • a flat body is understood to mean a body which has a greater extent in two of the three spatial directions in a Cartesian coordinate system than in the third spatial direction. If one thinks of the bubble away and one assumes that the main body has no curvature, then the expansion in the third spatial direction (z-direction, thickness of the film layer) is only a fraction of the expansion in the other two spatial directions (x and y -Direction).
  • the thickness of the film layer d G (expansion in the z direction) is preferably less than one-tenth of the expansion in the thickness perpendicular orthogonal spatial directions (x and y direction), more preferably less than one twentieth.
  • the flat body preferably has no or only a slight curvature.
  • the radius of curvature is at least 10 times the extent in the x and / or y direction. In a particularly preferred embodiment, the radius of curvature is at least 20 times the extent in the x and / or y direction. In a very particularly preferred embodiment, the radius of curvature is at least 50 times the extent in the x and / or y direction.
  • the flat basic body always has a certain curvature, even if the aim is to make the basic body (with the exception of the bladder) as flat as possible.
  • the introduction of the bladder into the body which is usually done by thermoforming, can cause stresses in the body that lead to a curvature.
  • the mechanical processing such as printing, cutting, gripping (e.g., during transportation), etc., bends may be introduced into the main body.
  • the application of the cover sheet represents a mechanical stress, which can lead to deformation.
  • an ideal, non-curved base body is assumed. However, this is done only to better illustrate the invention and should not be construed as limiting the invention.
  • the flat body can take many forms. It may assume a circular, oval, triangular, quadrangular (e.g., rectangular or square), pentagonal, hexagonal, and other basic shapes in the xy plane, the corners each being rounded.
  • the planar body has a square, rectangular or angular basic shape in the xy plane, but the corners may be rounded.
  • the term "angular” is explained in more detail below.
  • the corners of the flat body are rounded to avoid injury to the persons handling the individual blisters and / or damage to materials with which the Einzelblister come into contact.
  • the base body must be at least so large that a blister for receiving a drug portion can be introduced and the bladder can be closed with a cover foil.
  • a typical size is, for example, an extension in the x and y direction from 0.6 cm to 6 cm and in the z direction from 0.2 mm to 2 mm.
  • the main body can also be made larger or smaller.
  • information about the drug in the bladder is applied to the cover sheet.
  • information about the drug in the bladder may e.g. the name of the active substance, the name of the manufacturer and / or distributor, a lot number (Ch.B.), the expiry date, a dosage and other information.
  • Some information is required by authorities supervising the placing on the market of medicinal products, other information may be useful for the people involved in the packaged medicine, such as patients, doctors, nurses, transport and logistics companies, packers and others.
  • targeted colors may be used; conceivable is e.g. a red color for taking in the morning and a blue color for taking in the evening / night.
  • the ventral side is the side on which the bladder protrudes from the main body and which is opposite to the side on which the cover film is applied.
  • the main body therefore has a minimum size which allows at least the information required by the authorities to be applied to the base body and / or the cover film.
  • a certain minimum size also offers the advantages that the single blister is not lost so quickly, and that it is easier to handle and open especially for the elderly.
  • information can also be incorporated, for example, as an engraving in the base body and / or the cover sheet.
  • the bubble is introduced into the base body. It usually serves to receive a single portion of medication. But it is also conceivable that there are several drug portions in a bladder. For example, it is conceivable that the amount of drug a patient must take at a given time is too large for a single dose of medication to cause problems when swallowed. Therefore, it may be appropriate to distribute the drug to several, smaller drug portions.
  • the bladder contains a maximum of four drug portions; most preferably it contains a single drug portion.
  • the bladder may be centrally or decentrally incorporated in the body.
  • central and “decentralized” are explained in more detail below.
  • the cover film is applied to the so-called back side of the body and closes the bladder, which protrudes on the opposite side of the stomach from the body.
  • FIG. 1 clarifies this.
  • FIG. 1 shows an example of a single blister 1 in the top view and from two sides.
  • the Einzelblister 1 comprises a flat body 2, in which a bubble 3 is introduced.
  • the bladder 3 is a single drug portion (in the FIG. 1 not shown).
  • the bladder is closed by a cover sheet 4.
  • the bladder 3 is centrally introduced in the flat body 2.
  • the basic shape of the main body is rectangular-with the corners being rounded.
  • the cover sheet usually does not necessarily extend over the entire back side of the main body and ends flush with the edges of the main body.
  • the cover film preferably also has the basic shape of the base body and is ideally designed flat (without curvature).
  • the cover films are preferably in planes which run parallel to one another.
  • cover sheets are horizontal to gravity and the blister packs are stacked "one above the other".
  • coversheets are vertical to gravity and the blister packs are stacked "side-by-side”.
  • cover sheets can be brought by turning the stack in any other orientation between "vertical” and "horizontal”.
  • the present invention is not limited to any orientation of the stack with respect to gravity.
  • the term “stack” in the present description is broader than in the vernacular, which is usually understood to mean only a "superordinate arrangement”.
  • the term “height h s of the stacked arrangement” is not to be understood as meaning that only "stacked” individual blisters are the subject of the present invention.
  • the term “height” is here also broader than is usually understood. These considerations, which are based on parallel cover sheets, are not interpreted to be valid only for stacks with parallel cover sheets.
  • the present invention also includes, for example, stacks which are arranged “next to one another" and in which the cover sheets of the individual blisters do not lie in planes which run parallel to one another.
  • a stack is assumed in which the cover sheets of Einzelblister horizontal to gravity, the Einzelblister thus "superimposed” are arranged.
  • Under an adjacent Einzelblister is understood in such a stack that Einzelblister, which is in contact with the considered Einzelblister. In this case, the adjacent Einzelblister above or below the considered Einzelblisters.
  • the lowest single blister has only a single adjacent blister; this is above the lowest individual blister.
  • the uppermost Einzelblister also has only one adjacent Einzelblister; this is below the uppermost Einzelblister.
  • Typical numbers N of individual blisters in a stacked arrangement are 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 21, 28, 30 and 31. However, they are other quantities conceivable.
  • N is an integer in the range of 2 to 31.
  • N is equal to 7.
  • N is equal to 28.
  • the bubbles preferably point in the same direction.
  • the Einzelblister are each arranged alternately back side to back side and stomach side on the stomach side. Mixed forms between the mentioned stack shapes are also conceivable.
  • the stack height N ⁇ d G + d D + H B ⁇ H S ⁇ N ⁇ H B + d G + d D
  • h N denotes the height of the support structures, which are described in more detail below.
  • the individual blisters are stacked so that the cover sheet of a single blister rests against the body of an adjacent single blister in a region adjacent to the bladder.
  • FIG. 3 illustrates this embodiment.
  • FIG. 3 shows an example of an arrangement according to the invention in the top view (bottom) and from one side (top). Seven copies (1-1, 1-2, 1-3, 1-4, 1-5, 1-6, 1-7) of single blister 1 off Fig. 1 are stacked one above the other. All bubbles point in the same direction.
  • the Einzelblister 1-1 is arranged in the stack at the bottom.
  • the Einzelblister 1-2 is on the Einzelblister 1-1.
  • the cover sheet of the single blister 1-2 is applied to the main body of the adjacent single blister 1-1, in an area adjacent to the bladder.
  • For the Einzelblister 1-7 is indicated which side of the stomach side B and which side represents the back side R.
  • the abdominal side B is therefore the side on which the bladder 3 protrudes from the main body 2.
  • the back R is the side on which cover sheet 4 is applied, which closes the bladder 3.
  • F E is the surface area of a single single blister in the projection onto the plane that is parallel to the basic shape of the flat main body (xy plane) and F O is the overlap area of two adjacent blister blanks in the same projection plane.
  • the space requirement of a stacked arrangement according to the invention is less than the area requirement of juxtaposed individual blisters, since the individual blisters of the stacked arrangement overlap in the xy projection plane.
  • Preferred embodiments of stacks according to the invention are those which have a larger relative overlap area F o rel :
  • F O rel F O / F e ⁇ 1
  • F o rel is preferably from 0.3 to 1, particularly preferably from 0.5 to 1.
  • the size of the relative overlap area can be maximized in several ways, e.g. by a decentralized arrangement of the bubbles and / or by recesses in the base body, as will be explained in more detail below.
  • the bubbles of the individual blisters are arranged in a decentralized manner relative to the basic shape of the flat main body.
  • the center of the basic form of the planar basic body is determined either by its center of symmetry or, if the basic form has no center of symmetry, by the center of gravity of the basic form.
  • the bladder also has a center which is determined either by the center of symmetry or, if the bladder has no center of symmetry, by the center of gravity of the bladder.
  • a decentralized arrangement of the bladder means an arrangement in which the center of the bladder does not coincide with the center of the basic shape of the flat main body.
  • FIGS. 4 and 5 illustrate this embodiment.
  • FIG. 4 shows an example of a single blister 1 in the top view and from two sides.
  • the Einzelblister 1 comprises a flat body 2, in which a bubble 3 is introduced.
  • the bladder 3 is a single drug portion (in the FIG. 4 not shown).
  • the bladder is closed by a cover sheet 4.
  • the bladder 3 is introduced decentrally in the flat body 2.
  • the basic shape of the main body is rectangular-with the corners being rounded.
  • FIG. 5 shows an example of an arrangement according to the invention in the top view (bottom) and from one side (top). Seven copies (1-1, 1-2, 1-3, 1-4, 1-5, 1-6, 1-7) of single blister 1 off Fig. 4 are stacked one above the other. All bubbles point in the same direction.
  • each individual blister has a recess within which the bladder of an adjacent single blister can be placed. This also results in a denser packing both in the stacking direction and perpendicular thereto.
  • FIGS. 6 and 7 illustrate this embodiment.
  • the edges of the basic shape have a convex contour.
  • a circular, a square and a rectangular basic shape always have a convex contour (see, eg FIG. 6 ). If, by contrast, a semicircular recess is punched out in the edge region of a square basic shape, for example, the contour of the basic shape is no longer convex at all points but concave in the region of the recess.
  • base areas with recess are to be understood as meaning all base areas in which the contour also comprises at least one concave area in addition to convex areas.
  • the recess is preferably round, semicircular, elliptical, semi-elliptical or rectangular.
  • FIG. 6 shows an example.
  • Both each have a flat body 2, in which a blister 3 is incorporated for receiving a drug portion.
  • the bladder is decentralized with respect to the body.
  • Both basic bodies have a semicircular recess 5.
  • FIG. 7 shows how two of the individual blisters 1 and 1 'are arranged alternately stacked one above the other.
  • each individual blister on support structures.
  • the support structures may be incorporated as the bladder in the body. It is also conceivable that the support structures are applied to the base body. According to the invention, the support structures have a lower height than the bubble: h N ⁇ h B.
  • FIG. 8 shows an example.
  • a bubble 3 is disposed decentrally.
  • a circular recess 5 is introduced, in which a bubble of another single blister can be placed in a stack-shaped arrangement.
  • the base body also has support structures in the form of two support knobs 7, whose height h N is less than the height of the bubble h B.
  • FIG. 9 are two of the single blister FIG. 8 stacked.
  • the lower Einzelblister is rotated relative to the upper Einzelblister by 180 °, so that the bubble of the lower single blister falls exactly into the recess of the upper single blister.
  • the main body of the upper single blister abuts the supporting knobs of the lower single blister.
  • a special form of "footprint with recess” is the angular footprint, which is a particularly preferred embodiment.
  • the recess is rectangular.
  • An example of an angular base is shown in FIG. 10 shown.
  • An angular base area is understood to mean a surface in which two surface elements extend from a common surface in different directions and delimit a free area between the surface elements.
  • the bladder of a single blister falls into the free area between the surface elements of the main body of an adjacent single blister.
  • the surface elements running in different directions enclose an angle of less than 180 °.
  • the angle is in the range of 120 ° to 60 °, more preferably in the range of 100 ° to 80 °; most preferably, the angle is 90 °.
  • the surface elements running in different directions are of the same shape; preferably they are rectangular. They can be the same or different sizes. In a preferred embodiment, they are the same size; in another preferred embodiment, they have a different size.
  • FIG. 10 is a Einzelblister shown with an angular base body.
  • the base body 2 comprises two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and delimit a free area in which the bladder of a further single blister can be placed in a stacked arrangement.
  • the main body 2 has support structures in the form of supporting knobs 7, whose height h N is less than the height h B of the bubble 3rd
  • FIG. 11 shows in a plan view (bottom) and in a side view (open), as two of the individual blister FIG. 10 stacked on top of each other.
  • the bladder of each individual blister of a stack according to the invention is arranged decentrally with respect to the basic shape of the base body and the base body also has a recess in which the bladder of an adjacent single blister can be placed.
  • Figures 12 and 13 illustrate this embodiment.
  • a single blister 1 is shown, the base body 2 has two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and delimit a free area in which the bladder of another single blister can be placed in a stacked arrangement.
  • the base body 2 also has support structures in the form of a support web 8.
  • FIG. 13 is shown as three of the single blister FIG. 12 helically stacked on top of each other.
  • Figures 14 . 15 . 16 and 17 show further embodiments of the present invention, in which the drug portion and, accordingly, the bladder have an elongated shape.
  • the base body 2 has two rectangular surface elements 6 and 6 ', which are at an angle of 90 ° to each other and delimit a free area in which the bladder of another single blister can be placed in a stacked arrangement.
  • the surface elements 6 and 6 ' have a different size.
  • FIG. 15 are three of the single blister FIG. 15 stacked.
  • FIG. 16 shows a Einzelblister 1, in the base body 2, a bubble 3 is arranged decentralized.
  • a recess 5 is introduced, in which a bubble of a further single blister can be placed in a stack-shaped arrangement.
  • the main body also has support structures in the form of four support knobs 7, whose height h N is less than the height of the bubble h B.
  • FIG. 17 are two of the single blister FIG. 16 stacked.
  • the lower Einzelblister is rotated relative to the upper Einzelblister by 180 °, so that the bubble of the lower single blister falls exactly into the recess of the upper single blister.
  • the main body of the upper single blister abuts the supporting knobs of the lower single blister.
  • Another object of the present invention is a box containing a stacked arrangement of individual blisters according to the invention.
  • the box serves as secondary packaging. It usually also includes a leaflet with information about taking the medicine portions.
  • the box serves to stabilize the stacked arrangement according to the invention. It can consist of cardboard, plastic, metal or a composite material. In a preferred embodiment, the box is a carton carton, as used for conventional blister strips.
  • the box contains a viewing window, via which the remaining amount of the individual blisters present in the box can be determined.
  • the box has a lateral opening in the lower area of the box, over which a single blister of the box can be removed. Due to gravity, the remaining in the box Einzelblister slip upon removal of the lower single blister and can be removed one after another until the box is emptied.
  • FIG. 18 three boxes according to the invention are shown.
  • the right contains seven, the middle fourteen and the left 28 Einzelblister.
  • the left box has a viewing window on the side over which the remaining number of individual blisters can be determined.
  • the left box also has an opening in the lower area, over which the individual blisters can be removed laterally.
  • Another object of the present invention are individual blisters, which are particularly designed to allow a stacking according to the invention.
  • the individual blisters are characterized in that the bladder is arranged decentrally with respect to the base body. Particularly preferred embodiments are in the FIGS. 4 . 6 . 8th . 12 . 14 and 16 shown.
  • the individual blisters have a recess in which the bladder of an adjacent single blister can be placed in a stacked arrangement according to the invention. Particularly preferred embodiments are in the FIGS. 6 . 8th . 10 . 12 . 14 and 16 shown.
  • the basic body of the individual blister according to the invention has a rectangular or square basic shape, in which the corners are optionally rounded. Particularly preferred embodiments are in the FIGS. 4 . 6 . 8th , and 16 shown.
  • the main body of the individual blister according to the invention has an angular basic shape, in which the corners are optionally rounded. Particularly preferred embodiments are in the Figures 10 . 12 and 14 shown.
  • the Einzelblister exists in two different copies, which behave to each other as image and mirror image.
  • a particularly preferred embodiment is in FIG. 6 shown.
  • the flat basic body has one or more basic shapes which, apart from optionally rounded corners, allow tiling of a rectangular area.
  • Tiling also referred to as tiling, paving, or surface finish
  • Tiling is understood to mean the gapless and overlapping-free covering of a surface by means of uniform partial surfaces.
  • the basic forms of the flat basic body form the partial surfaces.
  • the advantage of the tiling is that the main body can be obtained by dividing a larger blister sheet, whereby fragmentation residues (cut remnants, waste) are reduced to a minimum.
  • FIGS. 1 . 4 . 8, 10 . 12 . 14 and 16 shown Einzelblister a tiling.
  • Another object of the present invention is a process for the preparation of Einzelblister invention.
  • the method according to the invention is characterized in that the individual blisters are separated from a sheet or web comprising a plurality of individual blisters.
  • the separation can be carried out by conventional methods such as laser cutting, mechanical cutting, stamping, etching, electron beam machining, ultrasound and water jet. These and other methods are e.g. described in DIN standards 8588, 8589 and 8590.
  • the individual blisters are produced from a macroblister, which in EP15182316.8 is described in more detail.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Stackable Containers (AREA)
  • Auxiliary Apparatuses For Manual Packaging Operations (AREA)
EP15186159.8A 2015-09-22 2015-09-22 Emballage transparent individuel destine a etre empile de maniere optimale Ceased EP3147233A1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
EP15186159.8A EP3147233A1 (fr) 2015-09-22 2015-09-22 Emballage transparent individuel destine a etre empile de maniere optimale
CA2999102A CA2999102A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalveolaires pour un empilement optimise
CN201680054965.6A CN108025847B (zh) 2015-09-22 2016-09-19 用于优化堆叠的个体泡罩包装件
EP16766968.8A EP3353086A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé
US15/761,737 US20180282040A1 (en) 2015-09-22 2016-09-19 Individual blister packs for optimized stacking
MX2018003577A MX2018003577A (es) 2015-09-22 2016-09-19 Blisters individuales para apilamiento optimizado.
SG11201802095WA SG11201802095WA (en) 2015-09-22 2016-09-19 Individual blister pack for optimized stacking
PCT/EP2016/072094 WO2017050665A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé
EA201890798A EA201890798A1 (ru) 2015-09-22 2016-09-19 Единичные блистерные пачки для оптимизированного пакетирования
PE2018000434A PE20180644A1 (es) 2015-09-22 2016-09-19 Blisters individuales para apilamiento optimizado
AU2016328423A AU2016328423A1 (en) 2015-09-22 2016-09-19 Individual blister pack for optimized stacking
KR1020187011040A KR20180054790A (ko) 2015-09-22 2016-09-19 최적화된 적층을 위한 개별 블리스터 팩
CR20180179A CR20180179A (es) 2015-09-22 2016-09-19 Blísters individuales para apilamiento optimizado
JP2018515063A JP2018527262A (ja) 2015-09-22 2016-09-19 最適化されたスタックのための個別ブリスターパック
MA042916A MA42916A (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé
IL258028A IL258028A (en) 2015-09-22 2018-03-12 Individual blister pack for optimized stacking
PH12018500593A PH12018500593A1 (en) 2015-09-22 2018-03-19 Individual blister pack for optimized stacking
SV2018005658A SV2018005658A (es) 2015-09-22 2018-03-22 Blisters individuales para apilamiento optimizado
CONC2018/0003056A CO2018003056A2 (es) 2015-09-22 2018-03-22 Blísters individuales para apilamiento optimizado
CL2018000758A CL2018000758A1 (es) 2015-09-22 2018-03-22 Blísters individuales para apilamiento optimizado
HK18109791.2A HK1250363A1 (zh) 2015-09-22 2018-07-30 用於優化堆叠的個體泡罩包裝件

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186159.8A EP3147233A1 (fr) 2015-09-22 2015-09-22 Emballage transparent individuel destine a etre empile de maniere optimale

Publications (1)

Publication Number Publication Date
EP3147233A1 true EP3147233A1 (fr) 2017-03-29

Family

ID=54198972

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15186159.8A Ceased EP3147233A1 (fr) 2015-09-22 2015-09-22 Emballage transparent individuel destine a etre empile de maniere optimale
EP16766968.8A Withdrawn EP3353086A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16766968.8A Withdrawn EP3353086A1 (fr) 2015-09-22 2016-09-19 Plaquettes monoalvéolaires pour un empilement optimisé

Country Status (20)

Country Link
US (1) US20180282040A1 (fr)
EP (2) EP3147233A1 (fr)
JP (1) JP2018527262A (fr)
KR (1) KR20180054790A (fr)
CN (1) CN108025847B (fr)
AU (1) AU2016328423A1 (fr)
CA (1) CA2999102A1 (fr)
CL (1) CL2018000758A1 (fr)
CO (1) CO2018003056A2 (fr)
CR (1) CR20180179A (fr)
EA (1) EA201890798A1 (fr)
HK (1) HK1250363A1 (fr)
IL (1) IL258028A (fr)
MA (1) MA42916A (fr)
MX (1) MX2018003577A (fr)
PE (1) PE20180644A1 (fr)
PH (1) PH12018500593A1 (fr)
SG (1) SG11201802095WA (fr)
SV (1) SV2018005658A (fr)
WO (1) WO2017050665A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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PL4058375T3 (pl) * 2019-11-14 2024-06-10 Perfetti Van Melle Benelux B.V. Opakowanie blistrowe ze wskazaniem przypadku naruszenia opakowania

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GB2184086A (en) 1985-07-29 1987-06-17 Frederick William Jefferies Blister pack apparatus and feeder apparatus
EP0679587A1 (fr) 1994-04-29 1995-11-02 McNEIL-PPC, INC. Emballage blister avec moyens de préhension
DE4429503A1 (de) * 1994-08-19 1996-02-22 Klaus A Dipl Ing Kreft Packung, insbesondere Arzneimittelpackung, und Verfahren zur Herstellung der Packung
DE19680564T1 (de) 1995-06-30 1997-09-18 Astra Ab Blisterpackung
DE29780456U1 (de) 1996-07-01 1999-06-02 AB Astra, Södertälje Blisterpackung
DE10044118A1 (de) 2000-09-07 2002-04-04 Bosch Gmbh Robert Blisterpackung
WO2013041098A1 (fr) * 2011-09-21 2013-03-28 Medcomb Holding Aps Récipient rigide jetable pour compositions pharmaceutiques

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Publication number Publication date
JP2018527262A (ja) 2018-09-20
MX2018003577A (es) 2018-06-19
SG11201802095WA (en) 2018-04-27
IL258028A (en) 2018-05-31
PE20180644A1 (es) 2018-04-16
CO2018003056A2 (es) 2018-06-12
CL2018000758A1 (es) 2018-08-17
EP3353086A1 (fr) 2018-08-01
CA2999102A1 (fr) 2017-03-30
KR20180054790A (ko) 2018-05-24
CR20180179A (es) 2018-05-28
SV2018005658A (es) 2018-10-02
MA42916A (fr) 2018-08-01
WO2017050665A1 (fr) 2017-03-30
CN108025847A (zh) 2018-05-11
HK1250363A1 (zh) 2018-12-14
US20180282040A1 (en) 2018-10-04
CN108025847B (zh) 2019-12-31
PH12018500593A1 (en) 2018-10-01
EA201890798A1 (ru) 2018-10-31
AU2016328423A1 (en) 2018-04-12

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