WO2016161239A1 - Fgfr/pd-1 combination therapy for the treatment of cancer - Google Patents

Fgfr/pd-1 combination therapy for the treatment of cancer Download PDF

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Publication number
WO2016161239A1
WO2016161239A1 PCT/US2016/025482 US2016025482W WO2016161239A1 WO 2016161239 A1 WO2016161239 A1 WO 2016161239A1 US 2016025482 W US2016025482 W US 2016025482W WO 2016161239 A1 WO2016161239 A1 WO 2016161239A1
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WO
WIPO (PCT)
Prior art keywords
fgfr
cancer
antibody
biological sample
fgfr2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/025482
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English (en)
French (fr)
Inventor
Matthew V. Lorenzi
Suso Jesus PLATERO
Raluca VERONA
Jayaprakash Karkera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Therapeutics Ltd
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56134542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2016161239(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2981603A priority Critical patent/CA2981603A1/en
Priority to AU2016243917A priority patent/AU2016243917A1/en
Priority to MYPI2017001408A priority patent/MY193705A/en
Priority to KR1020177031541A priority patent/KR102722130B1/ko
Priority to CN201680032226.7A priority patent/CN107889462A/zh
Priority to MX2017012552A priority patent/MX2017012552A/es
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Priority to TNP/2017/000421A priority patent/TN2017000421A1/en
Priority to EP16730046.6A priority patent/EP3277319A1/en
Priority to BR112017020973A priority patent/BR112017020973A2/pt
Priority to UAA201710675A priority patent/UA126786C2/uk
Priority to CR20170477A priority patent/CR20170477A/es
Priority to NZ736075A priority patent/NZ736075B2/en
Priority to JP2017551655A priority patent/JP7134628B2/ja
Priority to SG11201708093VA priority patent/SG11201708093VA/en
Priority to IL254673A priority patent/IL254673B2/en
Priority to EA201792191A priority patent/EA201792191A1/ru
Publication of WO2016161239A1 publication Critical patent/WO2016161239A1/en
Priority to PH12017501818A priority patent/PH12017501818A1/en
Anticipated expiration legal-status Critical
Priority to CONC2017/0011197A priority patent/CO2017011197A2/es
Priority to AU2022201060A priority patent/AU2022201060A1/en
Priority to AU2025204202A priority patent/AU2025204202A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Definitions

  • an antibody that blocks the interaction between PD-1 and PD-Ll and an FGFR inhibitor for the manufacture of a medicament for the treatment of cancer, in particular for the treatment of cancer in a patient wherein one or more FGFR variants are present in a biological sample from the patient.
  • the medicament contains a pharmaceutically effective amount of an antibody that blocks the interaction between PD-1 and PD-Ll and a pharmaceutically effective amount of an FGFR inhibitor, wherein the medicament is used in a patient wherein one or more FGFR variants are present in a biological sample from the patient.
  • FFPE formalin-fixed, paraffin-embedded
  • NSCLC non-small-cell lung carcinoma
  • SCLC small- cell lung cancer
  • FGFR fibroblast growth factor receptor
  • PD-1 programmeed cell death 1
  • PD-Ll programmeed death-ligand 1
  • FGFR3:TACC3 fusion between genes encoding FGFR3 and transforming acidic coiled-coil containing protein 3
  • FGFR3:BAIAP2L1 fusion between genes encoding FGFR3 and brain-specific angiogenesis inhibitor 1 -associated protein 2-like protein 1
  • FGFR2: AFF3 fusion between genes encoding FGFR2 and AF4 FMR2 family, member 3
  • FGFR2:BICC1 fusion between genes encoding FGFR2 and bi caudal C homolog 1
  • FGFR2: CASP7 fusion between genes encoding FGFR2 and caspase 7
  • FGFR2: CASP7 fusion between genes
  • antibody refers to (a) immunoglobulin polypeptides, i.e., polypeptides of the immunoglobulin family that contain an antigen binding site that specifically binds to a specific antigen (e.g., PD-1 or PD-Ll), including all immunoglobulin isotvpes (IgG, IgA, IgE, IgM, IgD, and IgY), classes (e.g.
  • SNP polymorphism
  • a pharmaceutically effective amount of an antibody that blocks the interaction between PD-1 and PD-Ll and a pharmaceutically effective amount of an FGFR inhibitor wherein the antibody that blocks the interaction between PD-1 and PD-L l and the FGFR inhibitor are administered if PD-Ll expression is high and one or more FGFR variants are present in a biological sample from the patient.
  • the methods can be carried out if the PD-Ll expression is low in the biological sample.
  • the methods can be carried out irrespectively of PD-L1 expression in the biological sample from the patient and can be based on the presence of one or more FGFR variants without factoring in PD-L1 expression.
  • the FGFR variants can be one or more FGFR fusion genes and one or more FGFR amplifications. In some embodiments, the FGFR variants can be one or more FGFR mutations and one or more FGFR amplifications. In yet other words,
  • the evaluating step can further comprise measuring an expression level of PD-L1 in the biological sample and the second administering step can compri se administering the FGFR inhibitor if the expression level of PD-L1 is low.
  • methods of treating cancer in a patient comprise:
  • administering to the patient a pharmaceutically effecti ve amount of an antibody that blocks the interaction between PD-1 and PD-Ll; monitoring the efficacy of the antibody; and if the antibody is not efficacious, evaluating a biological sample from the patient for a presence of one or more FGFR variants and measuring an expression level of PD-Ll in the biological sample, and administering to the patient a pharmaceutically effective amount of an FGFR inhibitor if the one or more FGFR variants are present and if the expression level of PD-Ll is low in the sample.
  • Suitable primer pairs for performing an amplification step include, but are not limited to, those disclosed in U.S. Provisional Patent App. No. 62/056, 159, U.S. Patent
  • the presence of one or more FGFR variants can be evaluated at any suitable time point including upon diagnosis, following tumor resection, following first-line therapy, during clinical treatment, or any combination thereof.
  • the biological sample from which PD-Ll expression is evaluated can be the same biological sample from which the presence of one or more FGFR variants are evaluated, or the biological samples from which PD-Ll expression is evaluated can be a different biological sample from which the presence of one or more FGFR variants are evaluated.
  • “Same biological sample” refers to a single sample from which both PD-Ll expression and FGFR variants are evaluated.
  • “Different biological sample” includes the same source of sample (blood, lymph fluid, bone marrow, a solid tumor sample, etc.) taken at different time points or different sources of sample.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
PCT/US2016/025482 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer Ceased WO2016161239A1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
NZ736075A NZ736075B2 (en) 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
UAA201710675A UA126786C2 (uk) 2015-04-03 2016-04-01 Fgfr/pd-1 комплексна терапія для лікування раку
MYPI2017001408A MY193705A (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
KR1020177031541A KR102722130B1 (ko) 2015-04-03 2016-04-01 암 치료를 위한 ｆｇｆｒ/ｐｄ-1 조합 요법
CN201680032226.7A CN107889462A (zh) 2015-04-03 2016-04-01 用于治疗癌症的fgfr/pd‑1组合疗法
MX2017012552A MX2017012552A (es) 2015-04-03 2016-04-01 Terapia de combinacion del receptor del factor de crecimiento de fibroblastos (fgfr)/muerte propragama 1 (pd-1) para el tratamiento del cancer.
AU2016243917A AU2016243917A1 (en) 2015-04-03 2016-04-01 FGFR/PD-1 combination therapy for the treatment of cancer
TNP/2017/000421A TN2017000421A1 (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
EP16730046.6A EP3277319A1 (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
BR112017020973A BR112017020973A2 (pt) 2015-04-03 2016-04-01 método para tratar câncer em um paciente
CR20170477A CR20170477A (es) 2015-04-03 2016-04-01 Terapia de combinacin del receptor del factor de crecimiento de fibroblastos (fgfr)/muerte programada 1 (pd 1) para el tratamiento del cncer
CA2981603A CA2981603A1 (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
EA201792191A EA201792191A1 (ru) 2015-04-03 2016-04-01 Комбинированная терапия fgfr/pd-1 для лечения злокачественной опухоли
JP2017551655A JP7134628B2 (ja) 2015-04-03 2016-04-01 癌治療のためのｆｇｆｒ／ｐｄ－１併用療法
SG11201708093VA SG11201708093VA (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer
IL254673A IL254673B2 (en) 2015-04-03 2016-04-01 Fgfr inhibitor in combination with an antibody that blocks the interaction between pd-1 and pd-l1 as a therapy for the treatment of cancer
PH12017501818A PH12017501818A1 (en) 2015-04-03 2017-10-03 Fgfr/pd-1 combination therapy for the treatment of cancer
CONC2017/0011197A CO2017011197A2 (es) 2015-04-03 2017-10-31 Terapia de combinación fgfr/pd-1 para el tratamiento del cancer
AU2022201060A AU2022201060A1 (en) 2015-04-03 2022-02-17 Fgfr/pd-1 combination therapy for the treatment of cancer
AU2025204202A AU2025204202A1 (en) 2015-04-03 2025-06-05 Fgfr/pd-1 combination therapy for the treatment of cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562142569P 2015-04-03 2015-04-03
US62/142,569 2015-04-03
US15/079,136 US10478494B2 (en) 2015-04-03 2016-03-24 FGFR/PD-1 combination therapy for the treatment of cancer
US15/079,136 2016-03-24

Publications (1)

Publication Number Publication Date
WO2016161239A1 true WO2016161239A1 (en) 2016-10-06

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PCT/US2016/025482 Ceased WO2016161239A1 (en) 2015-04-03 2016-04-01 Fgfr/pd-1 combination therapy for the treatment of cancer

Country Status (23)

Country Link
US (3) US10478494B2 (enExample)
EP (1) EP3277319A1 (enExample)
JP (1) JP7134628B2 (enExample)
KR (1) KR102722130B1 (enExample)
CN (1) CN107889462A (enExample)
AU (3) AU2016243917A1 (enExample)
BR (1) BR112017020973A2 (enExample)
CA (1) CA2981603A1 (enExample)
CL (1) CL2017002481A1 (enExample)
CO (1) CO2017011197A2 (enExample)
CR (1) CR20170477A (enExample)
EA (1) EA201792191A1 (enExample)
EC (1) ECSP17072756A (enExample)
IL (1) IL254673B2 (enExample)
MA (1) MA41858A (enExample)
MX (1) MX2017012552A (enExample)
MY (2) MY193705A (enExample)
PE (1) PE20180131A1 (enExample)
PH (1) PH12017501818A1 (enExample)
SG (2) SG10202100562RA (enExample)
TN (1) TN2017000421A1 (enExample)
UA (1) UA126786C2 (enExample)
WO (1) WO2016161239A1 (enExample)

Cited By (28)

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US10039759B2 (en) 2011-10-28 2018-08-07 Astex Therapeutics Ltd Quinolines as FGFR kinase modulators
US10045982B2 (en) 2011-10-28 2018-08-14 Astex Therapeutics Ltd Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors
US10052320B2 (en) 2011-10-28 2018-08-21 Astex Therapeutics Ltd Substituted quinoxalines as FGFR kinase inhibitors
US10085982B2 (en) 2014-03-26 2018-10-02 Astex Therapeutics Ltd Combinations
US10273281B2 (en) 2015-11-02 2019-04-30 Five Prime Therapeutics, Inc. CD80 extracellular domain polypeptides and their use in cancer treatment
US10272087B2 (en) 2012-05-30 2019-04-30 Astex Therapeutics Ltd Pteridines as FGFR inhibitors
US10421747B2 (en) 2014-03-26 2019-09-24 Astex Therapeutics Ltd Quinoxaline derivatives useful as FGFR kinase modulators
US10472419B2 (en) 2014-01-31 2019-11-12 Novartis Ag Antibody molecules to TIM-3 and uses thereof
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US10519137B2 (en) 2010-04-30 2019-12-31 Astex Therapeutics Ltd Pyrazolyl quinoxaline kinase inhibitors
JP2020505425A (ja) * 2017-02-06 2020-02-20 ヤンセン ファーマシューティカ エヌ．ベー． 癌治療
US10570204B2 (en) 2013-09-26 2020-02-25 The Medical College Of Wisconsin, Inc. Methods for treating hematologic cancers
US10736900B2 (en) 2014-03-26 2020-08-11 Astex Therapeutics Ltd Combinations of an FGFR inhibitor and an IGF1R inhibitor
US10752687B2 (en) 2014-01-24 2020-08-25 Novartis Ag Antibody molecules to PD-1 and uses thereof
US10898482B2 (en) 2015-02-10 2021-01-26 Astex Therapeutics Ltd Pharmaceutical compositions comprising N-(3,5-dimethoxyphenyl)-N'-1 methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
WO2021160763A1 (en) * 2020-02-12 2021-08-19 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors and anti-pd1 agents for the treatment of urothelial carcinoma
US11149090B2 (en) 2014-08-12 2021-10-19 Alligator Bioscience Ab Combination therapies with anti CD40 antibodies
US11155555B2 (en) 2015-09-23 2021-10-26 Janssen Pharmaceutica Nv Compounds
US11344620B2 (en) 2014-09-13 2022-05-31 Novartis Ag Combination therapies
EP3932427A4 (en) * 2019-02-28 2022-12-07 Taiho Pharmaceutical Co., Ltd. CANCER THERAPY USING A 3,5-DISUBSTITUTED BENZOLALKYNYL COMPOUND AND PEMBROLIZUMAB
US11542247B2 (en) 2015-09-23 2023-01-03 Janssen Pharmaceutica Nv Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
US11789010B2 (en) 2017-04-28 2023-10-17 Five Prime Therapeutics, Inc. Methods of treatment with CD80 extracellular domain polypeptides
US11833151B2 (en) 2018-03-19 2023-12-05 Taiho Pharmaceutical Co., Ltd. Pharmaceutical composition including sodium alkyl sulfate
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
US11975002B2 (en) 2016-03-04 2024-05-07 Taiho Pharmaceutical Co., Ltd. Preparation and composition for treatment of malignant tumors
WO2024120084A1 (zh) * 2022-12-07 2024-06-13 宜明昂科生物医药技术（上海）股份有限公司 使用cd24抗体和pd-1-pd-l1通路阻断抗体的癌症联合疗法
RU2822064C2 (ru) * 2019-02-28 2024-07-01 Тайхо Фармасьютикал Ко., Лтд. Противораковая терапия с применением соединений 3,5-дизамещенного бензолалкинила и пембролизумаба
US12252535B2 (en) 2014-03-14 2025-03-18 Novartis Ag Antibody molecules to LAG-3 and uses thereof

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KR101974254B1 (ko) 2013-07-18 2019-04-30 다이호야쿠힌고교 가부시키가이샤 Fgfr 저해제의 간헐 투여용 항종양제
US10124003B2 (en) 2013-07-18 2018-11-13 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for FGFR inhibitor-resistant cancer
PE20160190A1 (es) 2013-08-01 2016-04-28 Five Prime Therapeutics Inc Anticuerpos anti-fgfr2iiib afucosilados
MX389663B (es) 2014-10-14 2025-03-20 Novartis Ag Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
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