WO2015188119A1 - Improved t cell compositions - Google Patents

Improved t cell compositions Download PDF

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Publication number
WO2015188119A1
WO2015188119A1 PCT/US2015/034515 US2015034515W WO2015188119A1 WO 2015188119 A1 WO2015188119 A1 WO 2015188119A1 US 2015034515 W US2015034515 W US 2015034515W WO 2015188119 A1 WO2015188119 A1 WO 2015188119A1
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WO
WIPO (PCT)
Prior art keywords
cells
inhibitor
akt
pi3k
cell
Prior art date
Application number
PCT/US2015/034515
Other languages
English (en)
French (fr)
Inventor
Kevin FRIEDMAN
Original Assignee
Bluebird Bio, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54767459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2015188119(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP20205511.7A priority Critical patent/EP3828265A1/en
Priority to US15/316,792 priority patent/US10479975B2/en
Priority to RS20210077A priority patent/RS61406B1/sr
Priority to SG11201610170SA priority patent/SG11201610170SA/en
Priority to CN201580041781.1A priority patent/CN106793780B/zh
Priority to JP2016571002A priority patent/JP6663359B2/ja
Priority to SI201531484T priority patent/SI3151672T1/sl
Priority to KR1020237000250A priority patent/KR20230008915A/ko
Priority to AU2015269197A priority patent/AU2015269197B2/en
Priority to ES15802488T priority patent/ES2846811T3/es
Priority to PL15802488T priority patent/PL3151672T3/pl
Priority to NZ726989A priority patent/NZ726989A/en
Priority to EP15802488.5A priority patent/EP3151672B1/en
Application filed by Bluebird Bio, Inc. filed Critical Bluebird Bio, Inc.
Priority to BR112016028644A priority patent/BR112016028644B1/pt
Priority to DK15802488.5T priority patent/DK3151672T3/da
Priority to CA2951044A priority patent/CA2951044C/en
Priority to KR1020177000417A priority patent/KR102485855B1/ko
Priority to LTEP15802488.5T priority patent/LT3151672T/lt
Priority to RU2017100003A priority patent/RU2719030C2/ru
Priority to MX2016016076A priority patent/MX2016016076A/es
Publication of WO2015188119A1 publication Critical patent/WO2015188119A1/en
Priority to IL249313A priority patent/IL249313A0/en
Priority to ZA2016/08378A priority patent/ZA201608378B/en
Priority to AU2018274888A priority patent/AU2018274888C1/en
Priority to US16/597,471 priority patent/US11560547B2/en
Priority to AU2020201489A priority patent/AU2020201489B2/en
Priority to HRP20210116TT priority patent/HRP20210116T1/hr
Priority to CY20211100083T priority patent/CY1123823T1/el
Priority to US18/084,733 priority patent/US20230193202A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
PCT/US2015/034515 2014-06-06 2015-06-05 Improved t cell compositions WO2015188119A1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
BR112016028644A BR112016028644B1 (pt) 2014-06-06 2015-06-05 Método in vitro ou ex vivo para fabricar células t, composição compreendendo um agente de crioproteção e uma população de células efetoras imunes e usos terapêuticos dadita composição
DK15802488.5T DK3151672T3 (da) 2014-06-06 2015-06-05 Forbedrede t-celle-sammensætninger
US15/316,792 US10479975B2 (en) 2014-06-06 2015-06-05 Methods of making T cell compositions
SG11201610170SA SG11201610170SA (en) 2014-06-06 2015-06-05 Improved t cell compositions
CN201580041781.1A CN106793780B (zh) 2014-06-06 2015-06-05 改善的t细胞组合物
JP2016571002A JP6663359B2 (ja) 2014-06-06 2015-06-05 改善されたｔ細胞組成物
SI201531484T SI3151672T1 (sl) 2014-06-06 2015-06-05 Izboljšani T-celični sestavki
KR1020237000250A KR20230008915A (ko) 2014-06-06 2015-06-05 개선된 t 세포 조성물
AU2015269197A AU2015269197B2 (en) 2014-06-06 2015-06-05 Improved T cell compositions
ES15802488T ES2846811T3 (es) 2014-06-06 2015-06-05 Composiciones de células T mejoradas
PL15802488T PL3151672T3 (pl) 2014-06-06 2015-06-05 Ulepszone kompozycje limfocytów t
NZ726989A NZ726989A (en) 2014-06-06 2015-06-05 Improved t cell compositions
EP15802488.5A EP3151672B1 (en) 2014-06-06 2015-06-05 Improved t cell compositions
EP20205511.7A EP3828265A1 (en) 2014-06-06 2015-06-05 Improved t cell compositions
MX2016016076A MX2016016076A (es) 2014-06-06 2015-06-05 Composiciones de celulas t mejoradas.
RS20210077A RS61406B1 (sr) 2014-06-06 2015-06-05 Poboljšane kompozicije t ćelija
CA2951044A CA2951044C (en) 2014-06-06 2015-06-05 Improved t cell compositions
KR1020177000417A KR102485855B1 (ko) 2014-06-06 2015-06-05 개선된 t 세포 조성물
LTEP15802488.5T LT3151672T (lt) 2014-06-06 2015-06-05 Patobulintos t ląstelių kompozicijos
RU2017100003A RU2719030C2 (ru) 2014-06-06 2015-06-05 Улучшенные композиции на основе t-клеток
IL249313A IL249313A0 (en) 2014-06-06 2016-11-30 Enhanced t-cell preparations
ZA2016/08378A ZA201608378B (en) 2014-06-06 2016-12-05 Improved t cell compositions
AU2018274888A AU2018274888C1 (en) 2014-06-06 2018-12-05 Improved T cell compositions
US16/597,471 US11560547B2 (en) 2014-06-06 2019-10-09 Methods of making T cell compositions
AU2020201489A AU2020201489B2 (en) 2014-06-06 2020-02-28 Improved T cell compositions
HRP20210116TT HRP20210116T1 (hr) 2014-06-06 2021-01-22 Poboljšane kompozicije t stanica
CY20211100083T CY1123823T1 (el) 2014-06-06 2021-02-01 Βελτιωμενες συνθεσεις τ κυτταρων
US18/084,733 US20230193202A1 (en) 2014-06-06 2022-12-20 Methods for making t cell compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462008957P 2014-06-06 2014-06-06
US62/008,957 2014-06-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/316,792 A-371-Of-International US10479975B2 (en) 2014-06-06 2015-06-05 Methods of making T cell compositions
US16/597,471 Continuation US11560547B2 (en) 2014-06-06 2019-10-09 Methods of making T cell compositions

Publications (1)

Publication Number Publication Date
WO2015188119A1 true WO2015188119A1 (en) 2015-12-10

Family

ID=54767459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/034515 WO2015188119A1 (en) 2014-06-06 2015-06-05 Improved t cell compositions

Country Status (25)

Country Link
US (3) US10479975B2 (ko)
EP (2) EP3828265A1 (ko)
JP (2) JP6663359B2 (ko)
KR (2) KR20230008915A (ko)
CN (2) CN106793780B (ko)
AU (3) AU2015269197B2 (ko)
BR (1) BR112016028644B1 (ko)
CA (1) CA2951044C (ko)
CY (1) CY1123823T1 (ko)
DK (1) DK3151672T3 (ko)
ES (1) ES2846811T3 (ko)
HR (1) HRP20210116T1 (ko)
HU (1) HUE053101T2 (ko)
IL (1) IL249313A0 (ko)
LT (1) LT3151672T (ko)
MX (2) MX2016016076A (ko)
NZ (1) NZ726989A (ko)
PL (1) PL3151672T3 (ko)
PT (1) PT3151672T (ko)
RS (1) RS61406B1 (ko)
RU (1) RU2719030C2 (ko)
SG (3) SG10202108458XA (ko)
SI (1) SI3151672T1 (ko)
WO (1) WO2015188119A1 (ko)
ZA (2) ZA201608378B (ko)

Cited By (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105907790A (zh) * 2016-06-21 2016-08-31 林志国 特异性识别EGFRvⅢ的含CD70嵌合抗原受体修饰T细胞的制备方法
CN106222201A (zh) * 2016-08-27 2016-12-14 北京艺妙神州医疗科技有限公司 一种制备car‑t细胞的方法以及制得的car‑t细胞及其应用
US20160361404A1 (en) * 2008-05-02 2016-12-15 Immunovative Therapies, Ltd. Methods and compositions for inhibition of Treg cells
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