WO2015104464A1 - Procédé de purification d'acides aminés aromatiques - Google Patents
Procédé de purification d'acides aminés aromatiques Download PDFInfo
- Publication number
- WO2015104464A1 WO2015104464A1 PCT/FR2014/050015 FR2014050015W WO2015104464A1 WO 2015104464 A1 WO2015104464 A1 WO 2015104464A1 FR 2014050015 W FR2014050015 W FR 2014050015W WO 2015104464 A1 WO2015104464 A1 WO 2015104464A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- equal
- amino acid
- resin
- process according
- less
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Definitions
- the majority of these resin treatments are based on a "batch" type of implementation, that is, discontinuous.
- the resins are installed in columns, and the successive eluents (must containing the amino acid, rinsing water, regenerating solutions - saline, basic, acidic or alcoholic) are percolated successively through the column.
- a concentrated amino acid stream on the one hand and a flow of eluent solution on the other hand are collected, the process comprising the recycling of this flow of eluent solution to the second elution step.
- the aromatic amino acid is preferably phenylalanine, tryptophan, tyrosine, histidine, or a derivative thereof.
- the pH in the first step is less than or equal to pKb-3; or less than or equal to pKb-3.5; or less than or equal to pKb-4; or less than or equal to pKb -4.5; or less than or equal to pKb-5; or less than or equal to pKb-5.5; or less than or equal to pKb-6.
- the product is treated on Applexion® XA2014-22 resin on a volume of 30 mL per column (in this example, 30 mL represents 1 BV where BV stands for bed volume, or Bed Volume, resin).
- the resin is a strong cationic resin, of the polystyrene-DVB polymer type with 8% DVB, with a 220 ⁇ monodisperse granulometry, and with an ion exchange capacity of 1.8 eq / L resin .
- the resin is previously converted to the Na form using a 4% sodium hydroxide solution.
- the starting mixture for the chromatography step contains 17.5 g / L of tryptophan, 3.7 g / L of residual sugars, and has a conductivity of 18.5 mS / cm induced by salts in solution.
- the eluent / feed ratio is 0.67 (volume / volume).
- tryptophan is eluted at 20 g / L (against 15 g / l in the feed product). More than 99% of Initial tryptophan is recovered in the extract during this step.
- the amount of NH 3 used is 0.59 mol per L of resin, for an amount of tryptophan injected with 1.47 mol / L of resin (ie 0.4 mole NH 3 per mole of tryptophan): this demonstrates that the retention mechanism is not ion exchange.
- the feed product is injected in excess on the resin at 4 BV / h: phenylalanine retention phenomenon is observed with respect to the salts and sugars, followed by leakage of the amino acid. Once the output concentration is equal to the input amino acid concentration, the feed injection is stopped.
- the elution of phenylalanine is made with a concentration of NH 3 of
- the feed product is injected in excess on the resin, at 2 BV / h: a retention phenomenon of histidine is observed, then a leakage of the amino acid. Once the output concentration is equal to the input amino acid concentration, the feed injection is stopped.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14701813.9A EP3092218B1 (fr) | 2014-01-07 | 2014-01-07 | Procédé de purification d'acides aminés aromatiques |
BR112016015718-4A BR112016015718B1 (pt) | 2014-01-07 | 2014-01-07 | Processo de purificação de aminoácidos aromáticos |
PCT/FR2014/050015 WO2015104464A1 (fr) | 2014-01-07 | 2014-01-07 | Procédé de purification d'acides aminés aromatiques |
JP2016545823A JP6303017B2 (ja) | 2014-01-07 | 2014-01-07 | 芳香族アミノ酸を精製する方法 |
US15/109,286 US10975031B2 (en) | 2014-01-07 | 2014-01-07 | Method for purifying aromatic amino acids |
KR1020167020336A KR102165406B1 (ko) | 2014-01-07 | 2014-01-07 | 방향족 아미노산의 정제 방법 |
CN202210570523.4A CN114874062A (zh) | 2014-01-07 | 2014-06-18 | 用于提纯芳香族氨基酸的方法 |
CN201410274032.0A CN104761423A (zh) | 2014-01-07 | 2014-06-18 | 用于提纯芳香族氨基酸的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FR2014/050015 WO2015104464A1 (fr) | 2014-01-07 | 2014-01-07 | Procédé de purification d'acides aminés aromatiques |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015104464A1 true WO2015104464A1 (fr) | 2015-07-16 |
Family
ID=50029144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2014/050015 WO2015104464A1 (fr) | 2014-01-07 | 2014-01-07 | Procédé de purification d'acides aminés aromatiques |
Country Status (7)
Country | Link |
---|---|
US (1) | US10975031B2 (fr) |
EP (1) | EP3092218B1 (fr) |
JP (1) | JP6303017B2 (fr) |
KR (1) | KR102165406B1 (fr) |
CN (2) | CN114874062A (fr) |
BR (1) | BR112016015718B1 (fr) |
WO (1) | WO2015104464A1 (fr) |
Cited By (8)
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WO2019097181A1 (fr) | 2017-11-16 | 2019-05-23 | Novasep Process | Procede de separation d'un melange avec mesure de purete ou rendement sur une cuve intermediaire |
WO2019097182A1 (fr) | 2017-11-16 | 2019-05-23 | Novasep Process | Procede de separation d'un melange avec mesure de purete ou rendement par un detecteur en ligne |
WO2019097180A1 (fr) | 2017-11-16 | 2019-05-23 | Novasep Process | Procede regule de separation d'un melange |
WO2019171004A1 (fr) | 2018-03-09 | 2019-09-12 | Novasep Process | Separation chromatographique du sulfate d'ammonium et de l'acide 2-hydroxy-2-methylpropionique |
EP3561080A1 (fr) | 2018-04-23 | 2019-10-30 | Novasep Process | Procede de fabrication de fructose a partir de glucose |
EP3560570A1 (fr) | 2018-04-23 | 2019-10-30 | Novasep Process | Procede de purification chromatographique de charges visqueuses |
EP3560571A1 (fr) | 2018-04-23 | 2019-10-30 | Novasep Process | Procede de purification de fructose |
US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
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WO2016164748A1 (fr) * | 2015-04-08 | 2016-10-13 | Invista North America S.A.R.L. | Matériaux et procédés pour le recueil sélectif de produits monovalents à partir de solutions aqueuses par échange d'ions en continu |
KR102577334B1 (ko) | 2021-05-21 | 2023-09-08 | 씨제이제일제당 (주) | 암모니아의 지속 가능한 순환이 가능한 방향족 아미노산의 결정화 방법 |
CN114082222B (zh) * | 2021-10-25 | 2023-03-17 | 青海大学 | 狭果茶藨子游离氨基酸纯化方法 |
Citations (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1502814A (fr) | 1965-09-21 | 1967-11-24 | Kyowa Hakko Kogyo Kk | Procédé d'isolement du tryptophane |
EP0027874A1 (fr) * | 1979-10-30 | 1981-05-06 | Degussa Aktiengesellschaft | Procédé d'isolation des acides aminés contenant au moins un cycle aromatique ou hétéroaromatique |
FR2557872A1 (fr) * | 1982-08-11 | 1985-07-12 | Mitsui Toatsu Chemicals | Procede d'isolement de l-amino-acides d'un melange reactionnel |
EP0200944A2 (fr) * | 1985-04-10 | 1986-11-12 | MITSUI TOATSU CHEMICALS, Inc. | Procédé de purification du tryptophane |
FR2581654A1 (fr) | 1985-01-25 | 1986-11-14 | Commissariat Energie Atomique | Procede de recuperation du tryptophane ou de l'un de ses derives et son utilisation dans un procede de synthese enzymatique du tryptophane |
EP0274728A1 (fr) | 1987-01-14 | 1988-07-20 | Ajinomoto Co., Ltd. | Procédé pour la purification de tryptophane |
EP0299715A2 (fr) | 1987-07-13 | 1989-01-18 | MITSUI TOATSU CHEMICALS, Inc. | Procédé de production de L-tryptophane |
EP0342629A1 (fr) | 1988-05-17 | 1989-11-23 | Mitsubishi Kasei Engineering Company | Méthode de séparation chromatographique |
JPH0297801A (ja) | 1988-10-04 | 1990-04-10 | Babcock Hitachi Kk | 排熱回収ボイラの補助蒸気抽気方法 |
US5102553A (en) | 1988-12-16 | 1992-04-07 | The Amalgamated Sugar Company | Time variable simulated moving bed process |
US5300653A (en) | 1989-11-20 | 1994-04-05 | Mitsui Toatsu Chemicals, Incorporated | Separation method of amino acids |
US5630943A (en) | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
US6063284A (en) | 1997-05-15 | 2000-05-16 | Em Industries, Inc. | Single column closed-loop recycling with periodic intra-profile injection |
US6136198A (en) | 1998-10-29 | 2000-10-24 | Institut Francais Du Petrole | Process and device for separation with variable-length |
EP1106602A1 (fr) * | 1999-12-09 | 2001-06-13 | Archer-Daniels-Midland Company | Purification chromatographiques en lit mobile simulé d'acides aminés |
US6375839B1 (en) | 1998-10-29 | 2002-04-23 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic zones |
US6413419B1 (en) | 1998-10-29 | 2002-07-02 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic |
WO2007012750A2 (fr) | 2005-07-26 | 2007-02-01 | Novasep | Procede et dispositif de separation de fractions d'un melange |
EP1756055A1 (fr) | 2004-03-19 | 2007-02-28 | Biosphere S.p.A. | Procede de purification de tryptophane |
CN101245047A (zh) | 2008-03-04 | 2008-08-20 | 汕头市紫光古汉氨基酸有限公司 | 色氨酸提纯方法 |
US7479228B2 (en) | 2002-08-02 | 2009-01-20 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method and device for chromatographic component separation |
CN101376646A (zh) | 2007-08-29 | 2009-03-04 | 天津科技大学 | 从发酵液中提取l-色氨酸的新方法 |
CN101691349A (zh) | 2009-10-20 | 2010-04-07 | 山东恩贝生物工程有限公司 | 一种从发酵液中提取色氨酸的工艺 |
CN101812009A (zh) | 2010-04-28 | 2010-08-25 | 河南巨龙淀粉实业有限公司 | 一种从发酵液中分离提取l-色氨酸的新工艺 |
CN101812488A (zh) | 2010-01-14 | 2010-08-25 | 天津启仁医药科技有限公司 | 一种微生物酶法拆分dl-半胱氨酸制备d-胱氨酸和l-色氨酸的方法 |
CN101948420A (zh) | 2010-09-28 | 2011-01-19 | 中国科学院西北高原生物研究所 | 一种从白刺果汁中分离纯化色氨酸单体的制备方法 |
CN102146052A (zh) | 2010-12-24 | 2011-08-10 | 山东鲁抗医药股份有限公司 | 一种制备色氨酸的方法 |
CN102382030A (zh) | 2011-12-16 | 2012-03-21 | 北京明新高科技发展有限公司 | L-色氨酸分离纯化的一种工艺 |
US8282831B2 (en) | 2007-04-17 | 2012-10-09 | Max-Planck-Gesellschaft zur Foderung der Wissenchaften e. V. | Method and apparatus for chromatographic component, separation with partial recirculation of mixture fractions |
US20130079527A1 (en) | 2010-05-12 | 2013-03-28 | Evonik Degussa Gmbh | Method for Separating off Tryptophan |
Family Cites Families (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2985589A (en) | 1957-05-22 | 1961-05-23 | Universal Oil Prod Co | Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets |
US3761533A (en) | 1970-07-23 | 1973-09-25 | Toray Industries | Separation process of components of feed mixture utilizing solid sorbent |
US3706812A (en) | 1970-12-07 | 1972-12-19 | Universal Oil Prod Co | Fluid-solid contacting apparatus |
US3696107A (en) | 1971-05-27 | 1972-10-03 | Richard W Neuzil | Improved hydrocarbon separation process |
GB1512516A (en) | 1974-07-31 | 1978-06-01 | Ici Ltd | Polyester composition |
US4048111A (en) | 1975-06-12 | 1977-09-13 | Uop Inc. | Method for manufacturing an adsorbent useful for olefin separation |
US4036745A (en) | 1975-09-24 | 1977-07-19 | Uop Inc. | Process for separating normal and isoparaffins |
US4049688A (en) | 1976-08-02 | 1977-09-20 | Uop Inc. | Process for separating esters of fatty acids by selective adsorption |
US4048205A (en) | 1976-08-02 | 1977-09-13 | Uop Inc. | Process for separating an ester of a monoethanoid fatty acid |
US4189442A (en) | 1978-10-18 | 1980-02-19 | The Procter & Gamble Company | Separation of fatty acid esters |
US4313015A (en) | 1980-02-07 | 1982-01-26 | Uop Inc. | Separation process |
US4353838A (en) | 1981-02-13 | 1982-10-12 | Uop Inc. | Process for separating a monoethanoid fatty acid |
US4353839A (en) | 1981-02-25 | 1982-10-12 | Uop Inc. | Process for separating saturated fatty acids |
US4519952A (en) | 1981-04-10 | 1985-05-28 | Uop Inc. | Process for separating fatty acids from unsaponifiables |
US4404145A (en) | 1981-04-10 | 1983-09-13 | Uop Inc. | Process for separating fatty acids from rosin acids |
US4524030A (en) | 1981-04-10 | 1985-06-18 | Uop Inc. | Process for separating fatty acids |
IN158368B (fr) | 1981-04-10 | 1986-11-01 | Uop Inc | |
US4329280A (en) | 1981-04-10 | 1982-05-11 | Uop Inc. | Process for separating esters of fatty and rosin acids |
US4522761A (en) | 1981-04-10 | 1985-06-11 | Uop Inc. | Process for separating fatty acids from rosin acids |
US4511514A (en) | 1981-04-10 | 1985-04-16 | Uop Inc. | Process for separating oleic acid from linoleic acid |
US4486618A (en) | 1981-07-30 | 1984-12-04 | Uop Inc. | Process for separating C6 olefin hydrocarbons |
JPS5861463A (ja) | 1981-10-07 | 1983-04-12 | Kureha Chem Ind Co Ltd | 液体クロマトグラフイ−用担体及び該担体を用いる脂溶性物質の分離精製方法 |
JPS58109444A (ja) | 1981-11-19 | 1983-06-29 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はそのエステル、ドコサヘキサエン酸又はそのエステルの分離精製法 |
JPS5888339A (ja) | 1981-11-20 | 1983-05-26 | Kagakuhin Kensa Kyokai | エイコサペンタエン酸又はそのエステルとドコサヘキサエン酸又はそのエステルの分離精製方法 |
US4460675A (en) | 1982-01-21 | 1984-07-17 | E. I. Du Pont De Nemours And Company | Process for preparing an overcoated photopolymer printing plate |
US4495106A (en) | 1982-08-13 | 1985-01-22 | Uop Inc. | Adsorbent and process for separating fatty acids from rosin acids |
US4560675A (en) | 1982-08-13 | 1985-12-24 | Uop Inc. | Adsorbent for separating fatty acids from rosin acids |
US4521343A (en) | 1983-02-04 | 1985-06-04 | Uop Inc. | Process for separating fatty acids from rosin acids with phosphorus modified alumina molecular sieve |
US4433195A (en) | 1983-03-02 | 1984-02-21 | Uop Inc. | Separation of trans- and cis-olefins |
US4524029A (en) | 1983-09-22 | 1985-06-18 | Uop Inc. | Process for separating fatty acids |
JPS60197209A (ja) | 1984-03-21 | 1985-10-05 | Soken Kagaku Kk | 液体クロマトグラフィーによる工業的分離法およびその装置 |
US4764276A (en) | 1984-07-30 | 1988-08-16 | Advanced Separation Technologies Incorporated | Device for continuous contacting of fluids and solids |
JPS61192797A (ja) | 1985-02-21 | 1986-08-27 | 日本油脂株式会社 | 高度不飽和酸の濃縮方法 |
US4605783A (en) | 1985-03-21 | 1986-08-12 | Uop Inc. | Process for separating monoterpenes |
JPH0761996B2 (ja) | 1986-03-18 | 1995-07-05 | 三井東圧化学株式会社 | トリプトフアンの精製方法 |
NO157302C (no) | 1985-12-19 | 1988-02-24 | Norsk Hydro As | Fremgangsmaate for fremstilling av et fiskeoljekonsentrat. |
US4797233A (en) | 1986-08-20 | 1989-01-10 | Uop Inc. | Process for separating mono-, di- and triglycerides |
US5068419A (en) | 1986-12-18 | 1991-11-26 | Uop | Separation of an organic acid from a fermentation broth with an anionic polymeric adsorbent |
US4720579A (en) | 1986-12-18 | 1988-01-19 | Uop Inc. | Separation of citric acid from fermentation broth with a neutral polymeric adsorbent |
IT1205043B (it) | 1987-05-28 | 1989-03-10 | Innova Di Ridolfi Flora & C S | Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri |
US4882065A (en) | 1987-12-11 | 1989-11-21 | Uop | Purification of sterols with activated carbon as adsorbent and chlorobenzene as desorbent |
JPH0692595B2 (ja) | 1988-02-01 | 1994-11-16 | 鐘淵化学工業株式会社 | 脂肪酸とトリグリセリドの分離方法 |
US4961881A (en) | 1988-02-17 | 1990-10-09 | Uop | Process for separating triglycerides and regenerating absorbent used in said separation process |
GB8819110D0 (en) | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
ZA895758B (en) | 1988-09-29 | 1990-04-25 | Fishing Ind Research I | Polyunsaturated fatty acids |
US4902829A (en) | 1988-11-16 | 1990-02-20 | Uop | Process for the adsorptive separation of hydroxy paraffinic dicarboxylic acids from olefinic dicarboxylic acids |
US5068418A (en) | 1989-05-08 | 1991-11-26 | Uop | Separation of lactic acid from fermentation broth with an anionic polymeric absorbent |
FR2651148B1 (fr) | 1989-08-28 | 1992-05-07 | Inst Francais Du Petrole | Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen de deux solvants. |
FR2651149B1 (fr) | 1989-08-28 | 1992-06-05 | Inst Francais Du Petrole | Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen d'un seul solvant a deux temperatures et/ou a deux pressions differentes. |
US5069883A (en) | 1989-10-20 | 1991-12-03 | Progress Water Technologies Corp. | Device for continuous contacting of liquids and solids |
US5225580A (en) | 1990-08-16 | 1993-07-06 | Uop | Process for separating fatty acids and triglycerides |
US5179219A (en) | 1990-11-19 | 1993-01-12 | Uop | Process for separating fatty acids and triglycerides |
JPH07106281B2 (ja) | 1991-01-16 | 1995-11-15 | 綜研化学株式会社 | 多成分混合物の分離精製方法及び装置 |
JP3400466B2 (ja) | 1991-10-28 | 2003-04-28 | 日本水産株式会社 | 高純度エイコサペンタエン酸またはそのエステルの製造方法 |
JP2993253B2 (ja) | 1991-12-24 | 1999-12-20 | 雪印乳業株式会社 | コレステロール含量の低い動物性油脂の製造法 |
JP3135964B2 (ja) | 1991-12-24 | 2001-02-19 | 雪印乳業株式会社 | コレステロール含量を低減させた飲食品の製造法 |
EP0592646B1 (fr) | 1992-04-29 | 1999-02-03 | Institut Francais Du Petrole | Procede et dispositif de fractionnement d'un melange en lit mobile simule en presence d'un gaz comprime, d'un fluide supercritique ou d'un liquide subcritique |
JP3025590B2 (ja) | 1992-10-14 | 2000-03-27 | エーザイ株式会社 | 粗製物の精製法 |
JP3340182B2 (ja) | 1993-03-31 | 2002-11-05 | 雪印乳業株式会社 | ドコサヘキサエン酸含有トリグリセリドの製造法 |
ES2097047T3 (es) | 1993-04-29 | 1997-03-16 | Norsk Hydro As | Procedimientos para el fraccionamiento cromatografico de acidos grasos y sus derivados. |
US5790181A (en) | 1993-08-25 | 1998-08-04 | Australian National University | Panoramic surveillance system |
GB9404483D0 (en) | 1994-03-08 | 1994-04-20 | Norsk Hydro As | Refining marine oil compositions |
JPH08218091A (ja) | 1995-02-17 | 1996-08-27 | Maruha Corp | 高純度の高度不飽和脂肪酸およびその誘導体の製造方法 |
EP0760393B1 (fr) | 1995-08-17 | 2003-06-04 | F. Hoffmann-La Roche Ag | Procédé de chromatographie |
FR2740451B1 (fr) | 1995-10-27 | 1998-01-16 | Seripharm | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
JP2815562B2 (ja) | 1995-11-13 | 1998-10-27 | 植田製油株式会社 | 高度不飽和脂肪酸含有油脂の精製方法 |
JPH09157684A (ja) | 1995-12-08 | 1997-06-17 | Chlorine Eng Corp Ltd | 高度不飽和脂肪酸エステルの精製方法 |
US5917068A (en) | 1995-12-29 | 1999-06-29 | Eastman Chemical Company | Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds |
DE19611094C2 (de) | 1996-03-21 | 1999-06-17 | Dresden Arzneimittel | Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens |
FR2754731B1 (fr) | 1996-10-18 | 1999-07-02 | Novasep Sa | Perfectionnement aux procedes d'enrichissement d'isomeres optiques par lit mobile simule |
GB9701705D0 (en) | 1997-01-28 | 1997-03-19 | Norsk Hydro As | Purifying polyunsatured fatty acid glycerides |
AU6043598A (en) | 1997-01-29 | 1998-08-18 | Amalgamated Research, Inc. | Method of displacement chromatography |
JPH10310555A (ja) | 1997-05-12 | 1998-11-24 | Y M Shii:Kk | 多価不飽和脂肪酸エステルの分離精製方法 |
FR2764822B1 (fr) | 1997-06-19 | 1999-08-13 | Novasep | Methode pour optimiser le fonctionnement d'un systeme de separation des constituants d'un melange |
FR2766385B1 (fr) | 1997-07-24 | 1999-09-03 | Novasep | Procede pour le controle de la pression dans un systeme de separation a lit mobile simule |
US5840181A (en) | 1997-10-14 | 1998-11-24 | Uop Llc | Chromatographic separation of fatty acids using ultrahydrophobic silicalite |
ATE251482T1 (de) | 1998-01-03 | 2003-10-15 | Innovata Biomed Ltd | Füllungsverfahren |
JP2872986B1 (ja) | 1998-01-21 | 1999-03-24 | 池田食研株式会社 | 高純度高度不飽和脂肪酸の低級アルコールエステル精製方法 |
US6350890B1 (en) | 1998-07-22 | 2002-02-26 | Axiva Gmbh | Method for obtaining fatty acids from biomass by combined in/situ extraction, reaction and chromatography using compressed gases |
FR2781388B1 (fr) | 1998-07-24 | 2000-08-25 | Inst Francais Du Petrole | Dispositif de regulation en continu de la composition d'un melange de composants et systeme de separation de constituants incorporant ce dispositif d'analyse |
DK1128881T3 (da) | 1998-10-29 | 2005-10-03 | Inst Francais Du Petrole | Fremgangsmåde til adskillelse med kromatografiske områder med variabel længde |
GB9901809D0 (en) | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
IT1308613B1 (it) | 1999-02-17 | 2002-01-09 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella prevenzione di eventi cardiovascolari. |
NO312973B1 (no) | 1999-02-17 | 2002-07-22 | Norsk Hydro As | Lipase-katalysert forestring av marine oljer |
CA2311974A1 (fr) | 1999-06-28 | 2000-12-28 | Nisshin Flour Milling Co., Ltd. | Procedes pour la separation selective et la purification des acides eicosapentanoique et docosahexanoique et de leurs esters |
US6544413B1 (en) | 1999-11-02 | 2003-04-08 | Daicel Chemical Industries, Ltd. | Simulated moving bed device |
JP4170542B2 (ja) | 1999-11-18 | 2008-10-22 | 日油株式会社 | 高度不飽和脂肪酸誘導体の製造方法及び高純度エイコサペンタエン酸誘導体 |
CA2290885A1 (fr) | 1999-12-02 | 2001-06-02 | Universite De Sherbrooke | Methode pour la transformation des tissus du loup marin |
US6325598B1 (en) | 1999-12-23 | 2001-12-04 | Visteon Global Technologies, Inc. | Variable capacity swash plate type compressor having pressure relief valve |
AU2001223942A1 (en) | 2000-01-14 | 2001-07-24 | Olafur Halldorsson | Marine lipid composition for feeding aquatic organisms |
ES2324975T3 (es) | 2000-01-14 | 2009-08-21 | Epax As | Metodo para el cultivo de organismos presa ricos en adh para especies acuaticas. |
EP1125914A1 (fr) | 2000-02-14 | 2001-08-22 | Nisshin Flour Milling Co., Ltd. | Procédé de séparation et de purification d'acide eicosapentaénoique ou d'un ester de celui-ci |
DE60104833T2 (de) * | 2000-03-29 | 2005-03-24 | Archer Daniels Midland Co., Decatur | Verfahren zur abtrennung von einer basischen aminosäure aus fermentationsbrühen |
WO2001087452A2 (fr) | 2000-05-16 | 2001-11-22 | Purdue Research Foundation | Conception d'ondes stationnaires de lits mobiles simules uniques ou tandem destinee a la resolution de melanges a composants multiples |
EP1349866B1 (fr) | 2000-05-16 | 2007-04-04 | Purdue Research Foundation | Purification de l'insuline selon une technologie a lit mobile simule |
AU2001274836A1 (en) | 2000-05-16 | 2001-11-26 | Purdue Research Foundation | Standing wave design of a nine-zone smb for the recovery of a solute with intermediate affinity in a ternary mixture |
ATE305810T1 (de) | 2000-05-22 | 2005-10-15 | Pro Aparts Investimentos E Con | Fettsäure enthaltende pharmazeutische zusammensetzung die wenigstens 80 gew. epa und dha enthält |
FR2810897B1 (fr) | 2000-06-28 | 2002-10-11 | Novasep | Procede et dispositif de separation en lit mobile simule d'au moins un constituant dans des colonnes ayant un rapport longueur sur diametre approprie |
WO2002040129A2 (fr) | 2000-11-15 | 2002-05-23 | Purdue Research Foundation | Systemes et procedes destines a realiser des separations au moyen d'un dispositif a lit mobile simule |
FR2823134B1 (fr) | 2001-04-10 | 2003-09-19 | Novasep | Dispositif de protection du lit chromatographique dans les colonnes chromatographiques a compression axiale dynamique |
FI20010977A (fi) | 2001-05-09 | 2002-11-10 | Danisco Sweeteners Oy | Kromatografinen erotusmenetelmä |
US20030216543A1 (en) | 2001-05-16 | 2003-11-20 | Wang Nien-Hwa Linda | Insulin purification using simulated moving bed technology |
DE10151155A1 (de) | 2001-10-19 | 2003-05-08 | Nutrinova Gmbh | Native PUFA-Triglyceridmischungen mit einem hohen Gehalt an mehrfach ungesättigten Fettsäuren sowie Verfahren zu deren Herstellung und deren Verwendung |
FR2836230B1 (fr) | 2002-02-15 | 2004-04-23 | Novasep | Protection du lit chromatographique dans les dispositifs de chromatographie a compression axiale dynamique |
FR2836396B1 (fr) | 2002-02-22 | 2004-06-18 | Novasep | Procede et dispositif de chromatographie avec recuperation de solvant |
SE0202188D0 (sv) | 2002-07-11 | 2002-07-11 | Pronova Biocare As | A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product |
EP2295529B2 (fr) | 2002-07-11 | 2022-05-18 | Basf As | Procédé de diminution des polluants environnementaux dans une huile ou une graisse et produit d'alimentation pour poissons |
KR100481663B1 (ko) | 2002-09-24 | 2005-04-08 | 김희찬 | 중기공성 백금을 포함하는 바이오센서 및 이를 이용한글루코스 농도 측정방법 |
ES2550468T3 (es) | 2002-10-11 | 2015-11-10 | Nippon Suisan Kaisha, Ltd. | Procedimiento de producción de grasa o aceite microbiano que tiene un bajo contenido de materia no saponificable y dicha grasa o aceite |
FR2846252B1 (fr) | 2002-10-29 | 2005-07-01 | Novasep | Procede et dispositif de chromatographie integrant une etape de concentration |
NO319194B1 (no) | 2002-11-14 | 2005-06-27 | Pronova Biocare As | Lipase-katalysert forestringsfremgangsmate av marine oljer |
ITMI20032247A1 (it) | 2003-11-19 | 2005-05-20 | Tiberio Bruzzese | Interazione di derivati polari di composti insaturi con substrati inorganici |
US6979402B1 (en) | 2003-12-19 | 2005-12-27 | Uop Llc | Miniature actual moving bed assembly |
ES2563649T3 (es) | 2003-12-30 | 2016-03-15 | Dsm Ip Assets B.V. | Proceso de desaireación |
MY150129A (en) | 2004-04-09 | 2013-11-29 | Archer Daniels Midland Co | Method of preparing fatty acid alkyl esters from waste or recycled fatty acid stock |
US20060086667A1 (en) | 2004-09-13 | 2006-04-27 | Cephalon, Inc., U.S. Corporation | Methods for the separation of enantiomeric sulfinylacetamides |
CA2847960C (fr) | 2004-11-04 | 2015-02-10 | Monsanto Technology Llc | Procedes de preparation de compositions d'huile |
ITMI20051560A1 (it) | 2005-08-10 | 2007-02-11 | Tiberio Bruzzese | Composizione di acidi grassi n-3 con elevata concentrazione di epa e-o dha e contenente acidi grassi n-6 |
PE20070482A1 (es) | 2005-08-26 | 2007-06-08 | Ocean Nutrition Canada Ltd | Metodo para remover y/o reducir esteroles a partir de aceites |
US7544293B2 (en) | 2005-09-26 | 2009-06-09 | Semba Inc. | Valve and process for interrupted continuous flow chromatography |
BRPI0620310B1 (pt) | 2005-12-16 | 2017-12-05 | Archer-Daniels-Midland Company | A method for preparing a composition enriched in compounds containing unsaturated carbon chains by simulated moving bed chromatography using an adsorbent containing silver ions |
US7828978B2 (en) | 2006-01-11 | 2010-11-09 | Doug Geier | Simultaneous synthesis and purification of a fatty acid monoester biodiesel fuel |
FR2897277B1 (fr) | 2006-02-10 | 2008-04-18 | Novasep Soc Par Actions Simpli | Procede et dispositif de separation. |
FR2897238A1 (fr) | 2006-02-15 | 2007-08-17 | Novasep Soc Par Actions Simpli | Procede de purification de la thaumatine |
FR2898064A1 (fr) | 2006-03-03 | 2007-09-07 | Novasep Soc Par Actions Simpli | Dispositif de chromatographie modulaire |
FR2898283B1 (fr) | 2006-03-08 | 2011-07-15 | Novasep | Procede et dispositif de separation de fractions d'un melange. |
JP5112296B2 (ja) | 2006-03-15 | 2013-01-09 | 協和発酵バイオ株式会社 | アミノ酸の精製方法 |
WO2007119811A1 (fr) | 2006-04-13 | 2007-10-25 | Nippon Suisan Kaisha, Ltd. | Procédé de production d'huile d'acide gras poly-insaturée condensée |
WO2008149177A2 (fr) | 2006-05-05 | 2008-12-11 | Natural Asa | Compositions lipidiques marines et leurs utilisations |
WO2007144476A1 (fr) | 2006-06-16 | 2007-12-21 | Groupe Novasep | Procede de separation sequence multicolonnes |
EP2040810B1 (fr) | 2006-06-19 | 2019-04-17 | K.D. Pharma Bexbach GmbH | Procédé de chromatographie amélioré pour récupérer une substance ou un groupe de substances d'un mélange |
NZ573719A (en) | 2006-07-05 | 2011-08-26 | Photonz Corp Ltd | Production of ultrapure eicosapentaenoic acid and polar lipids from largely heterotrophic culture of nitzschia laevis |
WO2008025887A1 (fr) | 2006-08-28 | 2008-03-06 | Novasep | Procede d'enrichissement d'un ou plusieurs composes d'un melange utilisant une phase mobile liquide contenant un gaz |
FR2911793B1 (fr) | 2007-01-26 | 2010-07-30 | Novasep | Procede de separation par chromatographie |
US7901581B2 (en) | 2007-06-15 | 2011-03-08 | Ge Healthcare Bio-Sciences Ab | Chromatography method |
JP2010532418A (ja) | 2007-06-29 | 2010-10-07 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸のエステルの製造方法および精製方法 |
CA2694054C (fr) | 2007-07-25 | 2015-11-17 | Epax As | Composition enrichie en acides gras de type omega 3 |
FR2919200B1 (fr) | 2007-07-27 | 2009-10-30 | Novasep | Procede de cristallisation en continu |
JP5204776B2 (ja) | 2007-07-30 | 2013-06-05 | 日本水産株式会社 | Epa濃縮油およびdha濃縮油の製造方法 |
EP2247356A1 (fr) | 2008-02-21 | 2010-11-10 | Dow Global Technologies Inc. | Séparation d aldéhydes naturels dérivés du pétrole ou d'hydroxyméthylesters à l'aide d'une chromatographie industrielle |
FR2929533B1 (fr) | 2008-04-03 | 2010-04-30 | Novasep | Procede de separation multicolonnes a gradient. |
KR101357298B1 (ko) | 2008-06-20 | 2014-01-28 | 에이케이 앤 엠엔 바이오팜 주식회사 | 오메가-3계 고도불포화 지방산의 고순도 정제방법 |
WO2010018422A1 (fr) | 2008-08-14 | 2010-02-18 | Novasep | Procédé d’enrichissement d’isotopes |
EP2405902B1 (fr) | 2009-03-09 | 2021-07-21 | Basf As | Compositions comprenant un mélange d'huile d'acide gras et d'agent tensio-actif, et leurs procédés et utilisations |
CN101709048B (zh) * | 2009-11-11 | 2011-10-26 | 安徽丰原发酵技术工程研究有限公司 | 一种l-色氨酸的提取方法 |
CA2785742C (fr) | 2009-12-30 | 2015-02-17 | Basf Pharma (Callanish) Limited | Procede de separation chromatographique en lit mobile simule |
GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
JP5888339B2 (ja) | 2011-12-07 | 2016-03-22 | トヨタ自動車株式会社 | 表示制御装置 |
US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
EP2801604B1 (fr) | 2013-05-07 | 2017-04-12 | Groupe Novasep | Procédé chromatographique pour la production d'acides gras polyinsaturés hautement purifiés |
EP2883860B1 (fr) | 2013-12-11 | 2016-08-24 | Novasep Process | Procédé chromatographique de production d'acides gras polyinsaturés |
US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
-
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- 2014-01-07 WO PCT/FR2014/050015 patent/WO2015104464A1/fr active Application Filing
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Patent Citations (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1502814A (fr) | 1965-09-21 | 1967-11-24 | Kyowa Hakko Kogyo Kk | Procédé d'isolement du tryptophane |
EP0027874A1 (fr) * | 1979-10-30 | 1981-05-06 | Degussa Aktiengesellschaft | Procédé d'isolation des acides aminés contenant au moins un cycle aromatique ou hétéroaromatique |
FR2557872A1 (fr) * | 1982-08-11 | 1985-07-12 | Mitsui Toatsu Chemicals | Procede d'isolement de l-amino-acides d'un melange reactionnel |
FR2581654A1 (fr) | 1985-01-25 | 1986-11-14 | Commissariat Energie Atomique | Procede de recuperation du tryptophane ou de l'un de ses derives et son utilisation dans un procede de synthese enzymatique du tryptophane |
EP0200944A2 (fr) * | 1985-04-10 | 1986-11-12 | MITSUI TOATSU CHEMICALS, Inc. | Procédé de purification du tryptophane |
EP0274728A1 (fr) | 1987-01-14 | 1988-07-20 | Ajinomoto Co., Ltd. | Procédé pour la purification de tryptophane |
EP0299715A2 (fr) | 1987-07-13 | 1989-01-18 | MITSUI TOATSU CHEMICALS, Inc. | Procédé de production de L-tryptophane |
EP0342629A1 (fr) | 1988-05-17 | 1989-11-23 | Mitsubishi Kasei Engineering Company | Méthode de séparation chromatographique |
US5064539A (en) | 1988-05-17 | 1991-11-12 | Ryoka Techno Engineering & Construction Co. | Method of chromatographic separation |
JPH0297801A (ja) | 1988-10-04 | 1990-04-10 | Babcock Hitachi Kk | 排熱回収ボイラの補助蒸気抽気方法 |
US5102553A (en) | 1988-12-16 | 1992-04-07 | The Amalgamated Sugar Company | Time variable simulated moving bed process |
US5300653A (en) | 1989-11-20 | 1994-04-05 | Mitsui Toatsu Chemicals, Incorporated | Separation method of amino acids |
US5630943A (en) | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
US6063284A (en) | 1997-05-15 | 2000-05-16 | Em Industries, Inc. | Single column closed-loop recycling with periodic intra-profile injection |
US6375839B1 (en) | 1998-10-29 | 2002-04-23 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic zones |
US6136198A (en) | 1998-10-29 | 2000-10-24 | Institut Francais Du Petrole | Process and device for separation with variable-length |
US6413419B1 (en) | 1998-10-29 | 2002-07-02 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic |
US6712973B2 (en) | 1998-10-29 | 2004-03-30 | Institut Francais Du Petrole | Process and device for separation with variable-length chromatographic zones |
EP1106602A1 (fr) * | 1999-12-09 | 2001-06-13 | Archer-Daniels-Midland Company | Purification chromatographiques en lit mobile simulé d'acides aminés |
US7479228B2 (en) | 2002-08-02 | 2009-01-20 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method and device for chromatographic component separation |
EP1756055A1 (fr) | 2004-03-19 | 2007-02-28 | Biosphere S.p.A. | Procede de purification de tryptophane |
WO2007012750A2 (fr) | 2005-07-26 | 2007-02-01 | Novasep | Procede et dispositif de separation de fractions d'un melange |
US8282831B2 (en) | 2007-04-17 | 2012-10-09 | Max-Planck-Gesellschaft zur Foderung der Wissenchaften e. V. | Method and apparatus for chromatographic component, separation with partial recirculation of mixture fractions |
CN101376646A (zh) | 2007-08-29 | 2009-03-04 | 天津科技大学 | 从发酵液中提取l-色氨酸的新方法 |
CN101245047A (zh) | 2008-03-04 | 2008-08-20 | 汕头市紫光古汉氨基酸有限公司 | 色氨酸提纯方法 |
CN101691349A (zh) | 2009-10-20 | 2010-04-07 | 山东恩贝生物工程有限公司 | 一种从发酵液中提取色氨酸的工艺 |
CN101812488A (zh) | 2010-01-14 | 2010-08-25 | 天津启仁医药科技有限公司 | 一种微生物酶法拆分dl-半胱氨酸制备d-胱氨酸和l-色氨酸的方法 |
CN101812009A (zh) | 2010-04-28 | 2010-08-25 | 河南巨龙淀粉实业有限公司 | 一种从发酵液中分离提取l-色氨酸的新工艺 |
US20130079527A1 (en) | 2010-05-12 | 2013-03-28 | Evonik Degussa Gmbh | Method for Separating off Tryptophan |
CN101948420A (zh) | 2010-09-28 | 2011-01-19 | 中国科学院西北高原生物研究所 | 一种从白刺果汁中分离纯化色氨酸单体的制备方法 |
CN102146052A (zh) | 2010-12-24 | 2011-08-10 | 山东鲁抗医药股份有限公司 | 一种制备色氨酸的方法 |
CN102382030A (zh) | 2011-12-16 | 2012-03-21 | 北京明新高科技发展有限公司 | L-色氨酸分离纯化的一种工艺 |
Non-Patent Citations (2)
Title |
---|
KWANGNAM LEE: "Two Section Simulated Moving Bed Process", SEPARATION SCIENCE AND TECHNOLOGY, vol. 35, no. 4, 2000, pages 519 - 534 |
ZHANG ET AL.: "PowerFeed operation of simulated moving bed units: changing flow-rates during the switching interval", JOURNAL OF CHROMATOGRAPHY A, vol. 1006, 2003, pages 87 - 99 |
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US10975031B2 (en) | 2021-04-13 |
EP3092218A1 (fr) | 2016-11-16 |
KR102165406B1 (ko) | 2020-10-14 |
CN114874062A (zh) | 2022-08-09 |
BR112016015718A2 (pt) | 2017-08-08 |
KR20160105827A (ko) | 2016-09-07 |
CN104761423A (zh) | 2015-07-08 |
JP2017506620A (ja) | 2017-03-09 |
EP3092218B1 (fr) | 2022-03-09 |
BR112016015718B1 (pt) | 2021-12-07 |
US20160326112A1 (en) | 2016-11-10 |
JP6303017B2 (ja) | 2018-03-28 |
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