WO2012133052A1 - 混注装置 - Google Patents
混注装置 Download PDFInfo
- Publication number
- WO2012133052A1 WO2012133052A1 PCT/JP2012/057201 JP2012057201W WO2012133052A1 WO 2012133052 A1 WO2012133052 A1 WO 2012133052A1 JP 2012057201 W JP2012057201 W JP 2012057201W WO 2012133052 A1 WO2012133052 A1 WO 2012133052A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- syringe
- container
- infusion
- mixed injection
- vial
- Prior art date
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- HEMCGZPSGYRIOL-UHFFFAOYSA-N C(C1)C11CCCC1 Chemical compound C(C1)C11CCCC1 HEMCGZPSGYRIOL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
- A61M2207/10—Device therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/04—Tools for specific apparatus
- A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
Definitions
- This invention relates to a co-infusion apparatus for mixing and adjusting a drug such as an anticancer drug in an infusion solution (replacement fluid).
- mixed injection processing for mixing and adjusting such drugs in the infusion is performed in a safety cabinet set to a negative pressure. Then, when performing co-infusion using a vial in which a powdered medicine is sealed as the medicine, the medicine formulator sucks the infusion from the inside of the infusion bag with a syringe, and the syringe needle of the syringe is inserted into a vial cap (rubber). The infusion solution in the syringe is poured into the vial. Then, the drug compounder sucks the infusion solution in which the drug is dissolved into the syringe.
- the drug compounder Since a certain amount of the drug is sealed in the vial, the drug compounder repeatedly performs the operation of injecting and sucking the infusion into a plurality of vials until the required amount of the drug is dissolved in the infusion.
- the drug compounder dissolves a necessary amount of drug in the infusion solution, and then inserts the injection needle of the syringe into the mixed injection port of the infusion bag to return the infusion solution in which the drug in the syringe is dissolved into the infusion bag.
- Patent Document 1 discloses a radiopharmaceutical dispensing apparatus that dispenses while avoiding the risk of exposure to radiation drugs.
- the radiopharmaceutical dispensing apparatus includes a syringe holding means for holding a syringe, a first lifting / lowering means for moving the syringe holding means up and down, a piston part holding means for holding a piston part of the syringe, and the piston part holding means.
- a second raising / lowering means for moving the syringe up and down, and a rotating mechanism for rotating the syringe holding means, the first raising / lowering means, the piston part holding means, and the second raising / lowering means halfway.
- the radiopharmaceutical dispensing device of Patent Document 1 does not have a structure that can change the posture of the container or the mixing container.
- the infusion bag is temporarily used as a container.
- the vial is placed in the lower part of the device as a mixing container, when the syringe needle is inserted into the cap of the vial and the infusion in the syringe is poured into the vial, the infusion is upright. It is dripped directly toward the powdered drug existing at the bottom of the vial. That is, the infusion solution cannot be injected along the inner wall surface of the vial, which causes the infusion solution to foam or the infusion solution to directly strike the medicine in the vial.
- An object of the present invention is to prevent the above-mentioned infusion from bubbling when the infusion is injected into a medicine container in the co-infusion apparatus or the infusion directly against the medicine in the vial.
- the tip of the injection needle of the syringe is not attached to the bottom of the ampoule, and the drug solution can be sucked up without leaving as much as possible.
- the co-infusion apparatus of the present invention includes a container holding unit that holds a drug container and performs an operation of tilting the drug container, an operation of holding the syringe and tilting the syringe, and the syringe
- a container holding unit that holds a drug container and performs an operation of tilting the drug container
- an operation of holding the syringe and tilting the syringe and the syringe
- a syringe holding portion for performing an operation of changing the amount of insertion of the piston portion into the cylinder portion, an operation for inserting the injection needle of the syringe into the mouth portion of the drug container held by the container holding portion, and an injection of the syringe
- an insertion operation unit that performs an operation of inserting the needle into the mixed injection port of the infusion bag.
- the syringe needle of the syringe is inserted into the vial and the drug container and the syringe are inclined at the same angle, for example.
- the inner wall of the vial can be positioned vertically below the tip of the injection needle, while the tip of the vial remains facing the bottom of the vial. Accordingly, when the infusion solution in the syringe extracted from the infusion bag is poured into the vial, the infusion solution is dropped on the inner wall surface of the vial bottle, and gently poured into the bottom along the inner wall surface.
- the infusion solution can be prevented from foaming, or the infusion solution can be prevented from directly hitting the drug in the vial.
- the container holding portion and the syringe holding portion are supported by a support portion that is rotatably provided, and the drug container is inclined by the container holding portion by rotating the support portion.
- the operation and the tilting operation of the syringe by the syringe holding unit may be executed.
- the syringe holding part is supported by a support part that is rotatably provided, and the tilting operation of the syringe by the syringe holding part is executed by rotating the support part.
- the container holding part is provided so as to be movable along a curved path, and the drug container may be tilted by the curved path movement.
- the drug container in addition to the tilting operation of the drug container by the rotation of the support part, the drug container may be further tilted by a mechanism that independently rotates the container holding part.
- the drug container in addition to the tilting operation of the drug container by the curved path movement, the drug container may be further tilted by a mechanism that independently rotates the container holding part.
- the syringe holding part is supported by a support part that is rotatably provided, and the tilting operation of the syringe by the syringe holding part is executed by rotating the support part.
- the container holding part may be provided so as to linearly move in a horizontal direction or an oblique direction, and the tilting operation of the drug container may be executed by a mechanism that independently rotates the container holding part.
- the tip of the injection needle can be directed to the inner wall surface instead of the bottom of the vial.
- the operation of gently injecting the liquid along the inner wall surface of the vial can be performed more reliably.
- the syringe is positioned in an oblique state, and the ampule is laid sideways to form a state in which the drug solution is moved to the neck side of the ampule, thereby forming the syringe It is possible to suck up the liquid without leaving as much as possible without attaching the tip of the injection needle to the bottom of the ampoule.
- the mouth of the drug container held by the container holding part at the center of the single rotation of the container holding part The part should be located.
- the position of the mouth of the drug container is not displaced with respect to the position of the injection needle of the syringe, or the displacement can be reduced. It is possible to prevent the injection needle of the syringe from touching the drug container.
- the vial is used as the drug container, it is possible to prevent the hole formed by the injection needle inserted into the cap portion from becoming large due to the displacement of the injection needle.
- an ampule is used as the drug container, it is possible to more appropriately perform the process of sucking up the medicinal solution without leaving the tip of the injection needle of the syringe on the bottom of the ampule.
- the container holding unit is provided with a mechanism for moving the container holding unit, and the container holding unit is moved by moving the container holding unit.
- These configurations can also prevent the syringe needle of the syringe from touching the drug container.
- the displacement of the mouth portion of the drug container relative to the injection needle due to the single rotation of the container holding portion may be eliminated or reduced by moving the syringe holding portion. This configuration can also prevent the injection needle of the syringe from touching the drug container.
- the syringe holding portion that holds the syringe may include a blade member that grips the cylinder portion of the syringe and that is hard to get on the surface. According to this, since the blade member is hard to get into the surface of the cylinder part, the cylinder part slips in the piston moving direction when the piston part of the syringe is operated without increasing the force for gripping the cylinder part. Can be prevented.
- a piston part pulling operation for forming an air layer by combining air bubbles generated in the syringe with air taken into the syringe, and a piston part pushing for discharging the air layer You may make it perform operation. According to this, bubbles can be discharged from the syringe and the amount of liquid in the syringe can be read accurately.
- a piston pulling operation is performed to form air layers corresponding to one or several scales of the syringe by combining the air generated in the syringe with air taken into the syringe. You may do it. According to this, the amount of liquid in the syringe can be accurately read while an air layer is present in the syringe.
- FIGS. 4A and 4B are front views showing the container inclined portion provided in the third moving portion, respectively.
- FIGS. 4A and 4B are diagrams showing a co-infusion apparatus according to another embodiment of the present invention, in which the third moving unit is not supported by the support unit and has a structure in which the curved path moves independently. It is explanatory drawing which showed the apparatus.
- FIGS. 4A and 4B are views showing a co-infusion apparatus according to another embodiment of the present invention, and the co-infusion apparatus having a structure in which the third moving unit moves linearly independently without being supported by the support unit. It is explanatory drawing which showed. It is the perspective view which showed the external appearance of the co-infusion apparatus which concerns on embodiment of this invention. It is the perspective view which showed the other example of the holding mechanism of the syringe in the mixed injection apparatus of FIG.
- FIGS. 6A and 6B are views showing the relationship between the direction of cutting of the tip of the injection needle of the syringe set in the co-infusion apparatus of FIG. 1 and the drug container. It is explanatory drawing which showed the operation example for coping with the bubble which generate
- the main body of the co-infusion apparatus 1 is accommodated in the safety cabinet 100, and the operator A opens a window that covers the opening of the safety cabinet 100 to operate the main body (the vial 10). , Mounting of the syringe 11 and the infusion bag 12, etc.).
- a display 101, a barcode reader 102, and the like are provided on the outside of the side wall of the safety cabinet 100.
- the operator A causes the barcode reader 102 to read the barcode attached to the mixed injection procedure manual.
- the controller of the co-infusion apparatus 1 includes patient information, doctor information, co-infusion operation program, prescription content information (such as the type and number of drugs to be used), adjustment procedure information (dissolution source) specified by the read barcode. / Dissolution destination chemical, work content, volume / dissolution amount, sampling amount) is read from a storage unit (not shown).
- the mixed injection operation program differs depending on the type of drug container (whether a vial or ampoule is used), and the number of repetitions of the predetermined operation is determined by the number of drug containers used. Then, the controller displays the prescription content information and the adjustment procedure information on the display 101.
- the mixed injection device 1 is provided with a moving camera 103 that can image a syringe and a medicine container, and an image (audit image) captured by the moving camera 103 can also be displayed on the display 101.
- the main body of the mixed injection device 1 includes a transport device 2 that transports a vial 10 that is a medicine container, a mixing processing unit 3 that rocks the vial 10, the vial 10, and a syringe. 11, a transfusion back holding unit 5 that holds the transfusion bag 12, and an infusion back moving unit 6 that moves the transfusion back holding unit 5 closer to or away from the mixed transfusion operation unit 4 side.
- a transport device 2 that transports a vial 10 that is a medicine container
- a mixing processing unit 3 that rocks the vial 10, the vial 10, and a syringe.
- a transfusion back holding unit 5 that holds the transfusion bag 12
- an infusion back moving unit 6 that moves the transfusion back holding unit 5 closer to or away from the mixed transfusion operation unit 4 side.
- a motor 81 in the drive unit 8 is provided on the base 9, a motor 81 in the drive unit 8 is provided.
- a nut (not shown) provided on the lower surface of the movable table 83 that supports the conveying device 2 and the mixing processing unit 3 is screwed to the feed screw 82 connected to the rotation shaft of the motor 81.
- a slider portion 84 is fixed to the movable table 83, and the slider portion 84 is supported by a guide rail 85 fixed on the base 9.
- the transport device 2 includes a plurality of container setting portions 21 in which the vials 10 are set.
- the container setting unit 21 is connected to a conveyor belt 22 and is pivoted by the conveyor belt 22.
- the conveyor belt 22 is wound around two pulleys 23. When one of the pulleys 23 is rotated by a motor (not shown), the conveyor belt 22 is turned.
- One or a plurality of vials 10 are set using one or a plurality of the container setting sections 21.
- the movable table 83 is mixed and mixed to pass the vials 10 to the mixed injection operation unit 4. It moves straight to the operation unit 4 side.
- the mixing processing unit 3 Since the mixing processing unit 3 is located below the conveying device 2, when the movable table 83 is moved to the mixed injection operation unit 4 side and the vial 10 is passed to the mixed injection operation unit 4, The mixing processing unit 3 sinks below the mixed injection operation unit 4.
- the support base 31 constituting the mixing processing unit 3 is separated from the movable table 83 and can be moved independently.
- a front end side of the connecting rod 32 is connected to the lower surface of the support base 31, and a rear end side of the connecting rod 32 is connected to the crankshaft 33.
- the crankshaft 33 When the crankshaft 33 is rotated by a motor (not shown), the support base 31 is reciprocated in the direction of the arrow in the figure.
- the state shown in FIG. 2 is a state in which the vial 10 is placed sideways across the pair of rollers 34.
- the vial 10 is rotated.
- the bottom part and the cap part (mouth part) of the vial bottle 10 are supported by the rotation support part of the holder 35.
- the rotation support part on the side of the bottom part is provided in the main body part 351 of the holder 35, and the rotation support part 35a on the side of the cap part is provided in the movable part 35b.
- the movable portion 35b is screwed to the feed screw 35c, and the movable portion 35b is linearly moved by the rotation of the feed screw 35c.
- the upper end portion of the feed screw 35c is connected to a rotation shaft of a motor 36 provided at the upper end portion of the main body 351 of the holder 35, and the feed screw 35c is rotated by the rotation of the motor 36.
- the vial 10 is held by holding the bottom portion and the cap portion of the vial 10 with the rotation support portion of the holder 35, but the vial 10 is placed across the pair of rollers 34.
- the vial bottle 10 comes into contact with the surface of the roller 34 by gravity, and after this state is formed, the holding state by the holding portion 35 is formed again. is doing.
- the lower end portion of the main body 351 of the holder 35 is connected to the rotation shaft of the motor 37, and the holder 35 is swung by the rotational drive of the motor 37.
- the holder 35 receives the vial 10 from the mixed injection operation unit 4 after the infusion is poured into the vial 10.
- the holder 35 passes the vial 10 to the mixed injection operation unit 4 because the mixing processing unit 3 performs a shaking operation (reciprocating operation by the crankshaft 33 and rotating operation by the roller 34). Later.
- the movable table 83 is linearly moved.
- the mixed injection operation section 4 holds the cylinder section 11 a in the syringe 11 and moves the cylinder section 11 a in the piston section moving direction in the syringe 11.
- a rotation driving unit 45 that inclines the moving direction of the piston part with respect to the direction of gravity (vertical direction).
- the first moving part 41, the second moving part 42 and the support part 44 hold the syringe 11 and tilt the syringe 11 and the piston part 11b to the cylinder part 11a in the syringe.
- a syringe holder that performs an operation of changing the amount of insertion is configured.
- the first moving portion 41 is guided in the moving direction of the piston portion by engaging the slider portion 411 with a pair of guide rails 46 fixed to the supporting portion 44.
- a nut portion (not shown) is fixed to the back side of the main body portion of the first moving portion 41.
- a feed screw 412 is screwed into the nut portion.
- One end of the feed screw 412 is rotatably supported at the bottom of the support portion 44, and the other end is connected to a rotation shaft of a motor 413 fixed to the wall surface of the support portion 44.
- the feed screw 412 is rotated by the rotational drive of the motor 413, and the first moving portion 41 is linearly moved along the guide rail 46 by this rotation.
- a holding mechanism 414 for holding the cylinder part 11a is provided on the surface side of the main body part of the first moving part 41.
- the holding mechanism 414 includes a pair of claw portions 414a that sandwich the cylinder portion 11a from the lateral direction.
- the pair of claw portions 414a are respectively screwed into the screw portions of the feed screw 414b having screw portions whose threading directions are opposite to each other.
- the feed screw 414b is connected to the rotating shaft of the motor 414c.
- the feed screw 414b is rotated by the rotational drive of the motor 414c, and the rotation causes the pair of claw portions 414a to move toward and away from each other.
- the pair of claw portions 414a is formed with a recess for accommodating the flange portion of the cylinder portion 11a.
- the second moving portion 42 is guided in the moving direction of the piston portion by engaging the slider portion 421 with the pair of guide rails 46.
- a nut portion 422 is fixed to the back side of the main body portion of the second moving portion 42.
- a feed screw 423 is screwed into the nut portion 422.
- One end of the feed screw 423 is connected to a rotating shaft of a motor (not shown) fixed to the lower portion of the support portion 44, and the other end is supported by a bearing portion 425 fixed to the wall surface of the support portion 44. Yes.
- the feed screw 423 is rotated by the rotation of the motor, and the second moving portion 42 is linearly moved along the guide rail 46 by this rotation.
- a holding mechanism 424 for holding the end portion (saddle-like portion) of the piston portion 11b in the syringe 11 is provided on the surface side of the main body portion of the second moving portion 42.
- the holding mechanism 424 has a gap portion having an interval corresponding to the thickness of the end portion of the piston portion 11b. The end of the piston part 11b is held in the gap part, and the piston part 11b is moved in the piston part moving direction by moving the second moving part 42.
- the third moving unit 43 includes a first main body 431 and a second main body 432 disposed so as to surround the first main body 431.
- a guide rail 431 a is fixed laterally on the back side of the first main body 431.
- a slider portion 432a is fixed to the inner surface side of the back plate of the second main body portion 432, and the slider portion 432a is engaged with the guide rail 431a. That is, the second main body 432 is provided so as to be slidable in the lateral direction intersecting the guide rail 46 with respect to the first main body 431.
- the feed screw 431b is provided in the said horizontal direction in the back side of the said 1st main-body part 431, This feed screw 431b is connected with the rotating shaft of the motor 431c.
- a nut portion 432b is fixed to the inner surface side of the back plate of the second main body portion 432, and the feed screw 431b is screwed to the nut portion 432b.
- the second body portion 432 is provided with a container holding portion 436 (see FIGS. 4 and 5) described later.
- a container slide part 437 for moving the container holding part 436 in a direction intersecting the piston part moving direction by the second main body part 432, the slider part 432a, the guide rail 431a, the motor 431c, the nut part 432b, and the feed screw 431b. Is configured.
- the slider portion 431d is fixed to the first main body portion 431.
- the third moving part 43 is guided in the moving direction of the piston part by engaging the slider part 431d with the pair of guide rails 46.
- a nut portion (not shown) is fixed to the back surface side of the first main body portion 431 in the third moving portion 43.
- a feed screw 433 shown in FIG. 4 is screwed into the nut portion.
- the feed screw 433 is connected to a rotation shaft of a motor 434 fixed to the support portion 44.
- the feed screw 433 is rotated by the rotational drive of the motor 434, and the first main body 431 is moved along the guide rail 46 by this rotation.
- the second body part 432 is connected to the first body part 431 by the container slide part 437, and the first body part 431 and the second body part 432 move together as the third moving part 43. become.
- the vial 10 is formed on the surface side of the second main body 432 in the third moving part 43 by the rotation of the support part 44.
- a container tilting portion 435 for tilting the vial 10 further by rotating the container holding portion 436 alone is provided.
- the container holding part 436 is supported by a support part 435 a in the container inclined part 435.
- the support portion 435a is rotatably provided by a horizontal shaft 435b fixed to the second main body portion 432.
- a gear portion is formed on the support portion 435a.
- a worm gear 435c is engaged with the gear portion.
- the worm gear 435c is formed on the rotation shaft 435d.
- the rotation shaft 435d is rotated by a motor 435e fixed to the second main body 432.
- the support portion 435a is rotated, and the container holding portion 436 supported by the support portion 435a is rotated and inclined.
- the container holding part 436 includes a pair of claw parts 436 a for sandwiching the vial bottle 10 from the lateral direction.
- the pair of claw portions 436a are respectively screwed into the screw portions of the feed screw 436b having screw portions whose threading directions are opposite to each other.
- the feed screw 436b is connected to the rotation shaft of the motor 436c.
- the feed screw 436b is rotated by the rotational drive of the motor 436c, and the pair of claw portions 436a are moved closer to and away from each other by the rotation.
- the pair of claws 436a is formed with a triangular recess suitable for holding the vial 10 and an ampule 10A (not shown). Also, by controlling the torque of the motor 436c, the claw portion 436a grips the vial 10 or the like with an appropriate force.
- the rotation drive unit 45 includes a gear 452 rotatably supported by a cylindrical shaft 451 disposed horizontally.
- the cylindrical shaft 451 is provided on a back wall 91 erected on the base 9.
- a square attachment plate 453 is fixed to the gear 452, and the attachment plate 453 is rotated by the rotation of the gear 452.
- the support portion 44 is fixed to the mounting plate 453.
- a worm gear 454 is engaged with the lower side of the gear 452.
- the worm gear 454 is connected to the rotation shaft of the motor 455, and when the motor 455 rotates, the worm gear 454 is rotated.
- the motor 455 is fixed to a side wall 92 erected on the base 9.
- the power supply lines connected to the first, second and third moving parts 41, 42, 43, etc. provided on the support part 44 of the mixed injection operation part 4 can be taken out through the cylindrical shaft 45. I am doing so.
- the power supply line connected to the first moving unit 41 is stored in the cord storage rail 47 shown in FIG. 1, and the power supply line connected to the third moving unit 43 is connected to the cord storage rail 48. It is stored in.
- the infusion bag 12 is placed on the infusion bag holding unit 5 and held by a pair of holding claws 52.
- the pair of holding claws 52 are provided so as to sandwich the mixed injection port of the infusion bag 12 from the lateral direction, and are operated by a feed screw (not shown) having screw portions whose threading directions are opposite to each other.
- the infusion back holding part 5 is connected to the infusion back moving part 6 by a connecting part 51.
- a nut portion 51 a is fixed to the connecting portion 51.
- a feed screw 61 is disposed in the infusion back moving portion 6 in the lateral direction, and the nut portion 51 a is screwed to the feed screw 61.
- a slider portion (not shown) is fixed to the connecting portion 51, and the slider portion is provided on the infusion back movement portion 6 and engaged with a guide rail 63.
- a motor 62 is fixed to the back side of the main body of the infusion back moving unit 6.
- the feed screw 61 is connected to the rotating shaft of the motor 62 via a pulley and a belt (not shown). The feed screw 61 is rotated by the rotational drive of the motor 62, the connecting portion 51 is moved by the rotation, and the infusion bag holding portion 5 is moved by the movement of the connecting portion 51.
- the movement of the infusion bag holding unit 5 is executed when the injection needle of the syringe 11 is inserted into the mixed injection port of the infusion bag 12.
- the infusion back moving part 6 is connected and fixed to the distal end side of the arm part 71 in the infusion back inclined part 7.
- the rear end portion of the arm portion 71 is externally fitted to the cylindrical shaft 451, and the arm portion 71 swings around the cylindrical shaft 451.
- the center of the cylindrical shaft 451 is located on the central axis of the cylinder portion 11a of the syringe 11 held by the mixed injection operation portion 4.
- a nut portion 72 is provided on the back surface of the substantially central portion of the arm portion 71.
- the nut portion 72 is screwed into a feed screw 73 arranged in the vertical direction.
- the upper end of the feed screw 73 is supported by a bearing 73a, and the lower end is connected to a pulley 73b.
- the pulley 73b is configured such that the rotational driving force of the motor 73c is transmitted through the pulley 73d and the belt 73e.
- the infusion back moving part 6 is tilted and the infusion back holding part 5 is tilted.
- the nut portion 72 moved by the feed screw 73 moves up and down along a circular arc locus centering on the cylindrical shaft 451.
- a structure in which one end side of the feed screw 73 is movably provided to absorb the displacement due to the arc locus as described above, or the nut portion 72 that can absorb the displacement due to the arc locus as described above is used.
- An insertion operation unit that performs an operation of inserting the injection needle of the syringe 11 into the mixed injection port of the infusion bag 12 is configured. Note that the distance between the infusion bag 12 and the syringe 11 can be changed even if only one of the infusion bag 12 and the syringe 11 is moved. Therefore, the operation for inserting the injection needle into the mixed injection port of the infusion bag 12 is described above. Only one of the movement of the infusion bag 12 by the back movement unit 6 and the movement of the syringe 11 by the first movement unit 41 and the second movement unit 42 in the mixed injection operation unit 4 may be executed.
- This mixed injection process is executed by controlling each motor described above by the controller.
- a stepping motor is used as the motor controlled by the controller.
- the rotation angle of the rotating shaft in the stepping motor can be controlled, and by controlling the excitation mode of the coil, normal rotation and reverse rotation can be controlled. .
- FIG. 10 shows a state where the mixed injection operation unit 4 is upright. 10 to 25, the rotation drive unit 45, the support part 435a of the container inclined part 435, and the like are not shown.
- the mixed injection operation unit 4 rotates from the state shown in FIG. 10 as shown in FIG. 11 and points the injection needle of the syringe 11 obliquely upward.
- the infusion bag 12 is tilted by tilting the infusion bag holding part 5, and the mixed injection port of the infusion bag 12 in the oblique state and the injection needle of the syringe 11 in the oblique state face each other.
- the infusion back moving unit 6 moves the infusion back holding unit 5 to the mixed injection operation unit 4 side.
- the mixed injection operation unit 4 moves the first, second, and third moving units 41, 42, and 43 to bring the syringe 11 closer to the infusion bag 12 side.
- the injection needle of the syringe 11 can be inserted into the mixed injection port of the infusion bag 12.
- the state which pushed the piston part 11b into the cylinder part 11a of the syringe 11 is formed.
- the gap between the pair of claw portions 436a in the container holding portion 436 is increased so that the claw portions 436a do not interfere with the infusion back holding portion 5.
- the co-infusion apparatus 1 moves the second moving part 42 away from the position of the first moving part 41, so that the cylinder part 11 a of the syringe 11 is moved. An operation of pulling the piston portion 11b is performed. Thereby, the infusion in the infusion bag 12 is sucked into the cylinder part 11a.
- the second moving part 42 is moved by a prescribed distance so as to be sucked into the cylinder part 11a (a prescribed amount of pulse power is given to the motor).
- the mixed injection port of the infusion bag 12 is directed obliquely downward, the infusion solution is accumulated on the side of the mixed injection port, and the air moves away from the mixed injection port. Thereby, it is possible to reduce or avoid the air in the infusion bag 12 from entering the syringe 11 when the infusion solution is sucked by the syringe 11.
- the mixed injection device 1 rotates the support portion 44 of the mixed injection operation unit 4 to invert the syringe 11.
- the air in the cylinder portion 11a of the syringe 11 moves toward the injection needle.
- the cylinder part 11a is moved by moving the second moving part 42 closer to the position of the first moving part 41 so that the amount of infusion prescribed by the barcode of the mixed injection procedure manual is obtained. Let the air inside out.
- an operation for eliminating the tilt of the infusion bag holding unit 5 is also performed simultaneously.
- the support portion 44 of the mixed injection operation portion 4 is rotated so that the injection needle of the syringe 11 is directed directly below.
- the vial 10 is held by the pair of claws 436 a of the container holding part 436.
- an operation of bringing the transport device 2 closer to the mixed injection operation unit 4 by the drive unit 8 is executed.
- the support portion 44 of the mixed injection operation portion 4 is rotated to incline the syringe 11 and the vial bottle 10 in the clockwise direction, and the container holding portion 436 is singly rotated by the container inclined portion 435.
- the vial bottle 10 is further tilted clockwise in the figure while maintaining the posture of the syringe 11 as it is.
- the vial 10 is linearly moved to the left in the figure by the container slide portion 437.
- the center of rotation when the vial 10 is tilted is below the cap portion of the vial 10, the cap portion of the vial 10 moves to the right in the figure by tilting the vial 10. Will do.
- the vial 10 is linearly moved in the left direction by the container slide part 437 so as to cancel the right movement of the cap part.
- the container slide part 437 slides the container holding part 436 in the lateral direction in the inclined third moving part 43, the vial 10 is linearly moved in the diagonally upward left direction in FIG. It will be.
- FIG. 18 shows the syringe 11 and the vial bottle 10 in the state shown in FIG. 17 in an enlarged manner.
- the solid line in FIG. 18 shows a state in which the syringe 11 and the vial 10 are tilted clockwise
- the dotted line shows a state in which the vial 10 is further tilted clockwise while maintaining the posture of the syringe 11. Yes.
- the dashed-two dotted line in FIG. 18 has shown the state which moved the said vial bottle 10 linearly in the arrow direction.
- the syringe 11 and the vial 10 are tilted by 20 degrees, and the vial 10 is further tilted by 30 degrees from this tilted state.
- the moving distance of the vial 10 in the direction of the arrow is 7.7 mm.
- the infusion solution in the syringe 11 is poured into the vial bottle 10 by the linear movement and the rotation operation as described above, the infusion solution is dropped on the inner wall surface of the vial bottle 10. It is possible to gently pour into the bottom along the wall surface, and prevent the infusion from bubbling when the infusion is injected into the vial 10 or the infusion directly against the medicine in the vial 10. It is possible to prevent the infusion solution and the powder drug from being mixed in a foamed state. Then, when the vial bottle 10 is rotated and tilted, the vial bottle 10 is slid as described above to change the relative position between the vial bottle 10 and the injection needle inserted into the cap portion. Since it can reduce, it can prevent that the needle hole formed in the said cap part becomes large by the position displacement of the said injection needle. In other words, it is not necessary to use a cap portion (rubber plug) having excellent stretchability.
- FIG. 20 shows a state in which the second moving part 42 is moved closer to the first moving part 41 with the vial 10 tilted as described above, and the infusion solution in the syringe 11 is poured into the vial 10. Is shown. When the infusion solution in the syringe 11 is poured into the vial 10, the process of injecting the infusion solution into the vial 10 after taking the air in the vial 10 into the syringe 11 is repeated. ing.
- the support part 44 of the mixed injection operation part 4 is rotated to incline the syringe 11 and the vial bottle 10 by, for example, 20 degrees counterclockwise, and the container holding part by the container inclined part 435.
- the inclination of 436 is returned, and the positional relationship between the syringe 11 and the vial bottle 10 is returned to the non-inclined original state.
- the linear movement state of the vial 10 by the container slide portion 437 is also returned to the original state, and the syringe 11 is restored. Is placed at the center of the cap portion of the vial 10.
- the syringe 11 and the vial 10 are tilted counterclockwise by the rotation of the co-injection operation unit 4, so that the infusion in the vial 10 is opposite to the wall surface that is touched at the time of infusion. It becomes possible to prevent the presence of a drug that cannot be in contact with the infusion solution and does not dissolve in the vial 10.
- the support portion 44 of the mixed injection operation portion 4 is returned to the original straight state to erect the syringe 11, and the first moving portion 41 and the second moving portion 42 are moved to the third position.
- the moving unit 43 is moved upward.
- the vial 10 into which the infusion solution has been injected is transferred to the mixing processing unit 3 to perform a shaking process, and the drug is dissolved in the infusion solution. Then, after the mixing process, the vial 10 is transferred to the container holding unit 436 of the mixed injection operation unit 4 again.
- the support portion 44 of the mixed injection operation section 4 is rotated, and the syringe 11 and the vial bottle 10 are tilted clockwise by, for example, 160 degrees, so that the drug mixed infusion solution in the vial bottle 10 is obtained. Is moved to the cap side. In this state, the tip of the injection needle of the syringe 11 faces obliquely upward. In addition, air corresponding to the volume of the drug mixed infusion solution in the vial bottle 10 is taken into the syringe 11. And the process which moves the medicine mixing infusion solution in the said vial bottle 10 in the said syringe 11 and the process which moves the air in the said syringe 11 to the said vial bottle 10 side are performed several times. That is, the co-infusion apparatus 1 operates the piston 11b of the syringe 11 by operating the second moving unit 42 so that such processing is performed.
- the support section 44 of the mixed injection operation section 4 is further rotated so that the vial bottle 10 is turned upside down. All of the drug mixture infusion is transferred into the syringe 11. Thereafter, the air in the syringe 11 is discharged into the vial bottle 10.
- the co-infusion apparatus 1 rotates the support portion 44 of the co-infusion operation unit 4 to bring the non-inclined state (the syringe 11 and the like upright) in the co-infusion operation unit 4. State).
- the co-infusion apparatus 1 moves the first moving part 41 and the second moving part 42 to separate the syringe 11 from the vial bottle 10.
- the empty vial 10 is transferred to the transport device 2 and a new vial 10 is received by the container holding unit 436 in the third moving unit 43 of the mixed injection operation unit 4. Then, the above process is repeated until a prescribed amount of drug is dissolved in the infusion in the syringe 11.
- the infusion bag 12 When a prescribed amount of medicine is dissolved in the infusion solution in the syringe 11, for example, as shown by the solid line in FIG. 9, the infusion bag 12 is horizontally disposed in the infusion bag holding portion 5, and the mixture injection port is provided. The injection needle of the syringe 11 is inserted, and the infusion in the syringe 11 is returned to the infusion bag 12.
- the arm part 71 in the infusion bag inclination part 7 is inclined, and the infusion bag 12 has the infusion bag 12 in the state in which the infusion bag 12 is directed obliquely downward in the infusion bag holding part 5.
- the injection needle of the syringe 11 may be inserted into the mouth, and the medicine mixed infusion in the syringe 11 may be returned to the infusion bag 12.
- the arm portion 71 of the infusion bag inclined portion 7 is inclined to the side opposite to the state shown by the dotted line in FIG. 9, and the infusion bag 12 has the mixed injection port directed obliquely upward in the infusion bag holding portion 5.
- the injection needle of the syringe 11 may be inserted into the mixed injection port, and the medicine mixed infusion in the syringe 11 may be returned to the infusion bag 12.
- the container holding portion 436 is inclined by the container inclined portion 435.
- a configuration without the container inclined portion 435 may be employed.
- the tip of the injection needle faces the bottom of the vial 10. It is possible to position the inner wall surface of the vial 10 vertically below the tip of the injection needle although it remains in the state.
- the infusion solution in the syringe 11 is poured into the vial bottle 10
- the infusion solution can be hung on the inner wall surface of the vial bottle 10 and gently poured into the bottom along the inner wall surface. .
- a configuration that includes the container inclined portion 435 but does not include the container slide portion 437 may be employed.
- the injection needle of the syringe 11 is relatively moved to the edge side from the center of the cap portion of the vial 10.
- the infusion solution is dripped onto the inner wall surface of the vial 10 and the bottom is gently lowered. It becomes possible to pour into
- the ampoule 10A when the ampoule 10A is used, initially, the medicinal solution in the ampoule 10A is sucked into the syringe 11 in a state where the ampoule 10A is set up straight without rotating the mixed injection operation unit 4.
- the ampule 10A is a 5 ml container, 4 ml of the ampule is sucked up and 1 ml of chemical solution is left in the ampule 10.
- the ampoule 10A is not limited to stand upright as described above, and the ampoule 10A may be tilted by, for example, several degrees by operating the container inclined portion 435.
- the mixed injection device 1 tilts the syringe 11 and the ampoule 10A clockwise by, for example, 50 degrees as shown by a solid line in FIG. 27 after the 4 ml siphoning is completed or before the completion. Further, when the 4 ml siphoning is completed, the ampoule 10A is tilted by 50 degrees as shown by the dotted line in the figure, and the ampoule 10A is moved in the direction of the arrow as shown by the two-dot chain line in FIG. Move 4.0mm linearly.
- the overall 50-degree rotation of the syringe 11 and the ampoule 10A is performed by rotating the mixed injection operation unit 4 by the rotation drive unit 45, and the ampoule 10A is further rotated by 50 degrees. This is performed by single rotation of the container holding part 436 by the container inclined part 435.
- the linear movement of the ampoule 10A is performed by the container slide portion 437.
- the ampule 10A when used as the drug container, a certain amount of liquid medicine is sucked up with the ampule 10A set up as described above, and then the ampule 10A is tilted about 100 degrees from the state set up as described above.
- the tip of the injection needle of the syringe 11 is moved to the ampule 10A. It is possible to suck up the chemical without leaving the bottom without leaving as much as possible.
- a configuration without the container slide portion 437 may be employed.
- the injection needle of the syringe 11 moves relatively to the edge side from the center of the cut end of the ampoule 10A. Since the ampoule 10A has a larger cut end, the ampoule 10A can be tilted by the container inclined portion 435 within a range in which this movement is allowed. The drug solution can be sucked up as much as possible without attaching the tip of the injection needle to the bottom of the ampoule 10A.
- all of the holding mechanism 414 for holding the cylinder part 11a, the holding mechanism 424 for holding the piston part 11b in the syringe 11 and the container holding part 436 are moved in the piston part moving direction.
- the structure which does not move any one of the said holding mechanism 414, the holding mechanism 424, and the said container holding part 436 to the said piston part moving direction is also employable.
- the holding mechanism 424 that holds the piston portion 11b is fixedly arranged
- the holding mechanism 414 that holds the cylinder portion 11a and the container holding portion 436 are moved in the operation direction of the piston portion 11b that is fixedly arranged. Will be moved along.
- the direction along the operation direction of the piston portion 11b is the same direction as the piston portion moving direction, and is a direction in which the amount of insertion of the cylinder portion 11a into the piston portion 11b is changed.
- the movable table 83 is mixed to deliver the vial 10 to the mixed injection operation unit 4. Move to the operation unit 4 side.
- the distance from the cap part (mouth part) of the vial bottle 10 to the center of the horizontal axis 435b varies depending on the height of the vial bottle 10. Therefore, when the co-infusion apparatus 1 performs the co-infusion operation, the height data of the vial is stored for each type of vial in the storage unit of the controller (microcomputer), and is added to the mixed injection procedure manual. The height data is read from the storage unit from the information on the vial specified by the barcode, and the lateral slide amount of the vial 10 by the container slide unit 437 is calculated based on the read height data. Can do.
- the cap part (mouth part) of the vial 10 and The difference from the center of the horizontal axis 435b can be made zero.
- the claw portion 436a of the container holding portion 436 includes a feed screw 436d and a movable claw 436f screwed to the feed screw 436d, and one end side of the feed screw 436d is rotatable. While supporting, the other end side is connected with the rotating shaft of the motor 436e.
- the feed screw 436d is rotated by the motor 436e, the movable claw 436f is moved in the vertical direction (the height direction of the vial 10).
- the co-infusion apparatus 1 including the movable claw 436f receives the vial 10 set on the container setting unit 21 by the movable claw 436f, and then operates the motor 436e to move the vial 10 up and down.
- the cap portion of the vial 10 can be aligned with the center of the horizontal axis 435b.
- the controller may calculate the amount of movement of the movable claw 436f (number of pulses applied to the motor 436e) based on the height data of the vial. Instead of the height data for each vial, pulse number data for each vial may be stored in the storage unit of the controller (microcomputer).
- the operation of causing the cap portion of the vial 10 to coincide with the center of the horizontal axis 435b can be realized without the movable claw 436f.
- the third moving section 43 is moved in the vertical direction (vial bottle direction) according to the height of the vial bottle 10. 10 height direction).
- the horizontal axis 435b of the container inclined part 435 moves in the vertical direction together with the claw part 436a.
- the third moving portion 43 is moved to move the claw portion 436a and the horizontal shaft 435b in the vertical direction, so that the cap portion of the vial 10 is moved to the center of the horizontal shaft 435b.
- the distance can be zero.
- the distance according to the moving distance, the said 1st moving part 41, and the said 2nd moving part 42 are also moved.
- the support portion 44 itself is provided so as to be movable in the vertical direction, and before the vial bottle 10 set on the container setting portion 21 is transferred to the claw portion 436a, the support portion 44 is attached to the target vial bottle 10. You may make it move to the up-down direction by the distance according to the height.
- the container setting unit 21 is moved in the vertical direction (distance according to the height of the vial 10). (In the height direction).
- the distance from the cap unit of the vial 10 to the center of the horizontal shaft 435b can be made zero.
- the transport device 2 itself is provided so as to be movable in the vertical direction, and before the vial 10 set on the container setting unit 21 is transferred to the claw portion 436a, the transport device 2 is connected to the target vial 10. You may make it move to the distance according to height, and an up-down direction.
- the said 1st moving part 41, the 2nd moving part 42, and the 3rd moving part 43 were provided in the support part 44, it enabled it to perform the integral inclination of the chemical
- the third moving unit 43 is independently moved without being supported by the support unit 44.
- the third moving part 43 does not need to have a frame member composed of the first main body part 431 and the second main body part 432, and the container holding part 436, the container inclined part 435, It is enough to support.
- the third moving portion 43 is moved along a curved guide rail (not shown) so as not to hit the support portion 44.
- the curved guide rail is, for example, a circular arc, and the center of the circular arc coincides with the rotation center of the support portion 44. That is, in the configuration of FIG.
- the syringe holding portion is supported by the support portion 44 that is rotatably provided, and the tilting operation of the syringe 11 by the syringe holding portion is performed by rotating the support portion 44.
- the container holding part 436 tilts the medicine container (for example, ampoule 10A) by a curved path movement different from the rotation of the support part 44.
- the mixed injection process executed by the configuration shown in FIG. 30 can be performed by the same operation as that shown in FIGS.
- the curved guide rail is not limited to the arc as described above. Further, in the structure in which the third moving unit 43 is independently moved without being supported by the support unit 44, the third moving unit 43 can be moved in the vertical direction. It is possible to perform alignment between the mouth portion of the medicine container and the rotation center of the container holder 436 (the center of the horizontal shaft 435b).
- the third moving part 43 is not supported by the support part 44 and the third moving part 43 is independently in the lateral direction (horizontal direction, diagonal direction).
- a structure that moves linearly may be adopted.
- the third moving part 43 does not need to have a frame member composed of the first main body part 431 and the second main body part 432.
- the support portion 44 is rotated clockwise in the drawing to incline the syringe 11, the third moving portion 43 is linearly moved to the left in the drawing, and the container inclined portion 435 is operated. And tilt the ampoule 10A.
- the ampule 10A is not inclined by the linear movement, but is inclined only by the operation of the container inclined portion 435. Also in this structure, in addition to being able to tilt the drug container by the same angle as the syringe 11, the drug solution is moved to the neck side of the ampoule 10A by further tilting the ampoule 10A. A state can also be formed.
- the third moving part 43 is provided so as to be linearly movable in the lateral direction as described above, the mouth part of the drug container is displaced from the center of the horizontal axis 435b of the container inclined part 435.
- the positional displacement of the mouth portion that occurs when the third moving portion 43 is moved can be eliminated or reduced by linearly moving the third moving portion 43 in the lateral direction.
- the third moving unit 43 is provided so as to be linearly movable in the lateral direction as described above.
- the third moving unit 43 is fixed and the support unit 44 is the rotation driving unit 45. It is good also as providing so that it can move to the horizontal direction on the base 9.
- the infusion back holding part 5, the infusion back moving part 6 and the infusion back inclined part 7 are structured independently from the cylindrical shaft 451 of the support part 44, or the infusion back inclined part 7 And the like are structured to move linearly in the lateral direction together with the support portion 44. Even in such a structure, the positional displacement of the mouth portion that occurs when the mouth portion of the medicine container is displaced from the center of the horizontal axis 435b of the container inclined portion 435 is eliminated or reduced by the lateral linear movement. be able to.
- the third moving unit 43 can be moved laterally, and the support unit 44 can also be moved laterally.
- the tip of the injection needle and the body portion of the syringe 11 are positioned at the center of rotation of the support portion 44. In this way, even if the support portion 44 is rotated to incline the syringe 11, the position of the injection needle hardly changes.
- the container container can be inclined by the container inclined portion 435. There is almost no change in the position of the mouth.
- the drug container and the syringe 11 are inserted with the injection needle of the syringe 11 inserted into the mouth of the drug container. Both can be tilted appropriately.
- FIG. 33 is a perspective view showing a holding mechanism 415 having a form different from that of the holding mechanism 414.
- the holding mechanism 415 includes a pair of claw portions 415a that sandwich the cylinder portion 11a from the lateral direction.
- the movement support portions 415b that support the pair of claw portions 415a are respectively screwed into the screw portions of the feed screw 415c having screw portions whose threading directions are opposite to each other.
- the claw portion 415a includes two blade members 415d that are spaced apart from each other in the vertical direction.
- the tip blade portion of the blade member 415d enters, for example, a V shape, and the inserted portion comes into contact with the cylinder portion 11a.
- the cylinder portion 11a is made of resin, and the tip blade portion of the blade member 415d is hard to get into the surface when the cylinder portion 11a is gripped.
- This biting acts to prevent the cylinder part 11a from sliding in the piston movement direction, so that the cylinder part 11a can be firmly fixed without the cylinder part 11a being firmly held by the claw part 415a. Can be kept.
- the blade member 415d is prevented from being exposed by the cover member 415e except when the cylinder portion 11a is gripped.
- the cover member 415e is formed with a slit portion facing the blade member 415d, and the tip blade portion of the blade member 415d is not extended from the slit portion when the spring 415f is in a natural length.
- the cover member 415e first hits the cylinder portion 11a, the cover member 415e moves against the force of the spring 415f, and the tip of the blade member 415d. The blade portion is difficult to insert into the cylinder portion 11a.
- 34 (A), 34 (B), 34 (C), and 34 (D) show an example of operation when a drug solution is collected from the ampoule 10A by the syringe 11.
- FIG. 27 As shown in FIG. 27, when the ampoule 10A is further tilted with respect to the syringe 11, the mixed injection device 1 stops the movement of the piston portion 11b as shown in FIG. Suspend the suction and move the needle once away from the drug solution. However, when the injection needle is separated from the drug solution in this way, air may enter the injection needle. Therefore, as shown in FIG.
- the co-infusion apparatus 1 pushes the piston portion 11b in a state where the tip of the injection needle is immersed in the medicinal solution accumulated in the neck portion of the ampoule 10A in the inclined posture.
- the air in the injection needle is returned to the ampoule 10A together with the drug solution in the injection needle.
- the co-infusion apparatus 1 resumes the operation of pulling the piston portion 11b and resumes the collection of the chemical solution.
- the pushing movement amount of the said piston part 11b is made into the volume of an injection needle. Further, as shown in FIG.
- 35 (A) and 35 (B) are explanatory views showing the positional relationship between the tip cut surface of the injection needle and the ampoule 10A.
- the tip cut surface of the injection needle is in an upright state with respect to the inner wall surface of the ampoule 10A in the inclined posture, and the drug solution in the ampoule 10A is completely injected into the syringe. 11 may not be able to be sucked up.
- the tip cut surface of the injection needle is substantially parallel to the inner wall surface of the ampoule 10A in the inclined posture, and the chemical solution in the ampoule 10A. Can be completely sucked into the syringe 11.
- the syringe 11 when the syringe 11 is set in the co-infusion apparatus 1, it is arranged so that the scale is directed toward the near side in consideration of auditing. With this arrangement, the distal end cut surface of the injection needle is directed in a predetermined direction. It is desirable that the syringe 11 is manufactured as described above.
- an optical sensor may be provided in the co-infusion apparatus 1, and the direction of the cut surface at the tip of the injection needle may be detected by this optical sensor, and an error may be notified when the state shown in FIG.
- the optical sensor includes, for example, a light emitting unit and a light receiving unit. In the syringe 11 shown in FIG. 35A, light traveling to the light receiving unit is blocked due to the orientation of the tip cut surface of the injection needle. In the syringe 11 shown in FIG. 35 (B), the light emitting portion and the light receiving portion are arranged so that the light traveling to the light receiving portion is not blocked due to the direction of the tip cut surface of the injection needle.
- FIG. 36 shows an operation example for removing bubbles that have entered the syringe 11.
- the said co-infusion apparatus 1 performs the operation
- the said bubble B can be removed from the said cylinder part 11a, and the liquid quantity in a syringe can be read correctly.
- the bubble B is generated in a certain amount according to the volume of the injection needle, and the amount of the sucked air is also constant, so that the total amount of the air is finally added from the cylinder part 11a. What is necessary is just to move the said piston part 11b only a fixed distance in the pushing direction so that it may come out.
- FIG. 37 shows another example of operation for removing bubbles that have entered the syringe 11.
- the air layer shown in FIG. 36 is not discharged, and instead of the air layer being discharged, a volume corresponding to one scale (or a plurality of scales) may be given to the air layer. .
- a volume corresponding to one scale or a plurality of scales
- an air layer of one scale or several scales can be formed by setting the amount of air sucked into the syringe.
- the amount of medicinal solution can be read by subtracting the scale for the air layer from the scale value indicated on the end face of the piston portion 11b.
- FIG. 39 shows the operation of the pair of holding claws 52 of the infusion bag holding unit 5 in the co-infusion apparatus 1.
- the pair of holding claws 52 have taper portions on their facing surfaces.
- the tapered portion acts so as to move the mixed injection port to the mixed injection operation unit 4 side, that is, the side where the syringe 11 is located when the pair of holding claws 52 sandwich the mixed injection port of the infusion bag 12. .
- the infusion bag 12 (mixed injection port) is positioned at a certain location on the infusion bag holding unit 5.
- the force when the injection needle is stabbed into the mixed injection port can be received by the tapered portion to prevent the infusion bag 12 from being displaced.
- the injection needle of the syringe 11 is straightly inserted into the cap portion of the standing vial 10 and the vial 10 and the syringe 11 are integrally inclined at a predetermined angle.
- the manipulator operates the piston portion 11 b of the syringe 11 to inject the infusion solution in the syringe 11 into the vial 10.
- a first process of inserting the injection needle of the syringe 11 into the cut end of the ampoule 10A in a standing state and tilting the ampoule 10A and the syringe 11 integrally at a predetermined angle (in this case, the ampoule 10A is inserted into the syringe 11).
- the ampoule 10A may be tilted several times), and the ampoule 10A is further inclined with respect to the direction of movement of the piston portion of the syringe 11;
- the third process of adjusting the positional relationship between the ampoule 10A and the syringe 11 so that the injection needle continues to be positioned on the center side of the syringe may be automatically executed using a manipulator.
- the manipulator operates the piston portion 11b of the syringe 11 to suck the drug solution in the ampule 10A into the syringe 11.
- one manipulator serves as a container holding portion that holds the drug container (and further tilts the drug container), and the other manipulator tilts the syringe 11 and the syringe.
- 11 is a syringe holding portion that performs an operation of changing the amount of insertion of the piston portion 11b into the cylinder portion 11a.
- medical agent container is implement
- the operation of inserting the injection needle of the syringe 11 into the mixed injection port of the infusion bag 12 is realized by the manipulator holding the syringe 11.
- the third moving part 43 that is movable in the lateral direction provided with the container inclined part 435 and the container holding part 436 is employed, and the support part 44 and the first movement are provided.
- the component part which consists of the part 41 and the 2nd moving part 42 (The syringe which performs the operation
- a single manipulator robott arm
- FIGS. 34, 36 and 37 can also be executed by the manipulator.
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Abstract
Description
図32に示しているように、混注装置1の本体は、安全キャビネット100内に収容されており、オペレータAは上記安全キャビネット100の開口部を覆う窓を開けて上記本体に対する作業(バイアル瓶10、注射器11、輸液バック12の装着等)を行うことができる。上記安全キャビネット100の側壁の外側には、ディスプレイ101やバーコードリーダ102などが設けられている。オペレータAは処理開始にあたって、混注手順書に付記されているバーコードを上記バーコードリーダ102に読み取らせる。
10 バイアル瓶
10A アンプル
11 注射器
11a シリンダ部
11b ピストン部
2 搬送装置
3 混合処理部
4 混注操作部
41 第1移動部
414 保持機構
415 保持機構
42 第2移動部
424 保持機構
43 第3移動部
435 容器傾斜部
436 容器保持部
44 支持部
45 回動駆動部
5 輸液バック保持部
6 輸液バック移動部
7 輸液バック傾斜部
8 駆動部
9 基台
Claims (15)
- 薬剤容器を保持し、上記薬剤容器を傾斜させる動作を行う容器保持部と、
注射器を保持し、上記注射器を傾斜させる動作及び上記注射器におけるシリンダ部へのピストン部の挿入量を変化させる動作を行う注射器保持部と、
上記注射器の注射針を上記容器保持部により保持されている上記薬剤容器の口部に差し込む動作及び上記注射器の注射針を輸液バックの混注口に差し込む動作を行う差し込み動作部と、を備えたことを特徴とする混注装置。 - 請求項1に記載の混注装置において、回動可能に設けられた支持部に上記容器保持部と上記注射器保持部とが支持されており、上記支持部を回動させることで上記容器保持部による上記薬剤容器の傾斜動作と上記注射器保持部による上記注射器の傾斜動作とが実行されることを特徴とする混注装置。
- 請求項1に記載の混注装置において、回動可能に設けられた支持部に上記注射器保持部が支持されており、上記支持部を回動させることで上記注射器保持部による上記注射器の傾斜動作が実行される一方、上記容器保持部は曲線経路移動可能に設けられており、この曲線経路移動によって上記薬剤容器の傾斜動作が実行されることを特徴とする混注装置。
- 請求項2に記載の混注装置において、上記支持部の回動による上記薬剤容器の傾斜動作に加え、上記容器保持部を単独回動する機構によって上記薬剤容器を更に傾斜させることを特徴とする混注装置。
- 請求項3に記載の混注装置において、上記曲線経路移動による上記薬剤容器の傾斜動作に加え、上記容器保持部を単独回動する機構によって上記薬剤容器を更に傾斜させることを特徴とする混注装置。
- 請求項1に記載の混注装置において、回動可能に設けられた支持部に上記注射器保持部が支持されており、上記支持部を回動させることで上記注射器保持部による上記注射器の傾斜動作が実行される一方、上記容器保持部は水平方向又は斜め方向に直線移動するように設けられており、上記容器保持部を単独回動する機構によって上記薬剤容器の傾斜動作が実行されることを特徴とする混注装置。
- 請求項1に記載の混注装置において、上記容器保持部を単独回動する機構によって上記薬剤容器の傾斜動作が実行されることを特徴とする混注装置。
- 請求項4~請求項7のいずれか1項に記載の混注装置において、上記容器保持部の単独回動の回動中心部に上記容器保持部に保持される上記薬剤容器の口部を位置させることを特徴とする混注装置。
- 請求項4又は請求項5に記載の混注装置において、上記容器保持部を移動させる機構を備え、上記容器保持部を移動させることにより、上記容器保持部の単独回動による上記薬剤容器の口部の上記注射針に対する位置ずれを解消又は減少させることを特徴とする混注装置。
- 請求項6に記載の混注装置において、上記容器保持部の水平方向又は斜め方向直線移動により、上記容器保持部の単独回動による上記薬剤容器の口部の上記注射針に対する位置ずれを解消又は減少させることを特徴とする混注装置。
- 請求項7に記載の混注装置において、上記注射器保持部を移動させることにより、上記容器保持部の単独回動による上記薬剤容器の口部の上記注射針に対する位置ずれを解消又は減少させることを特徴とする混注装置。
- 請求項1~請求項11のいずれか1項に記載の混注装置において、上記注射器を保持する上記注射器保持部は上記注射器のシリンダ部を把持してその表面にくい込む刃部材を備えていることを特徴とする混注装置。
- 請求項1~請求項12のいずれか1項に記載の混注装置において、上記薬剤容器内の薬液を上記注射器内に吸い込む過程で、一旦注射針を薬液から離してから上記薬剤容器を傾斜させる動作を実行し、再び注射針を薬液に浸けて上記ピストン部を押す動作を行った後に上記ピストン部を引く動作を再開することを特徴とする混注装置。
- 請求項1~請求項13のいずれか1項に記載の混注装置において、上記注射器内に取り入れた空気に上記注射器内に生じている気泡を合体させて空気層を形成するためのピストン部引き動作と、上記空気層を排出するためのピストン部押し動作と、を行うことを特徴とする混注装置。
- 請求項1~請求項13のいずれか1項に記載の混注装置において、上記注射器内に取り入れた空気に上記注射器内に生じている気泡を合体させて上記注射器の1目盛り分または数目盛り分の空気層を形成するためのピストン部引き動作を行うことを特徴とする混注装置。
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JP2012552977A JP5224013B2 (ja) | 2011-03-25 | 2012-03-21 | 混注装置 |
KR1020137025051A KR101559219B1 (ko) | 2011-03-25 | 2012-03-21 | 혼합 주사 장치 |
US14/007,320 US20140020790A1 (en) | 2011-03-25 | 2012-03-21 | Co-infusion apparatus |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014065196A1 (ja) * | 2012-10-25 | 2014-05-01 | 株式会社湯山製作所 | 混注装置 |
US20140174600A1 (en) * | 2011-08-08 | 2014-06-26 | Yuyama Mfg. Co., Ltd. | Coinfusion apparatus |
EP2823798A1 (de) * | 2013-07-11 | 2015-01-14 | Weibel CDS AG | Vorrichtung zur Zusammenführung von Substanzen, insbesondere zur Rekonstitution von Injektionslösungen |
WO2015041092A1 (ja) * | 2013-09-19 | 2015-03-26 | 株式会社湯山製作所 | 混注装置、混注方法 |
WO2016009907A1 (ja) * | 2014-07-15 | 2016-01-21 | 株式会社湯山製作所 | 混注装置 |
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Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5829608B2 (ja) | 2009-07-29 | 2015-12-09 | アイシーユー・メディカル・インコーポレーテッド | 流体移行デバイスおよびその使用方法 |
KR102481494B1 (ko) | 2011-12-22 | 2022-12-26 | 아이씨유 메디칼 인코퍼레이티드 | 의료용 유체 전달 시스템, 유체 전달 방법, 전자 의료용 유체 전달 시스템, 및 전자 의료용 유체 전달 시스템 이용 방법 |
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CA2931195C (en) | 2013-11-25 | 2019-09-24 | Icu Medical, Inc. | Methods and systems for filling iv bags with therapeutic fluid |
JP2015167646A (ja) * | 2014-03-05 | 2015-09-28 | 株式会社安川電機 | ロボットシステム、液体移送制御装置、液体移送制御方法、及び薬剤製造方法 |
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WO2016148196A1 (ja) * | 2015-03-19 | 2016-09-22 | 株式会社湯山製作所 | 調剤管理装置、混注装置 |
JP6319224B2 (ja) * | 2015-08-11 | 2018-05-09 | 株式会社安川電機 | 薬液調製方法及び薬液調製システム |
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KR101882453B1 (ko) * | 2018-01-22 | 2018-08-30 | (주)동림의료기 | 방사선 약물 분배 장치 |
US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
CN111808735B (zh) * | 2020-07-16 | 2023-12-19 | 山东汇荣生物科技有限公司 | 一种生物氨基酸的生产系统 |
CN114795774B (zh) * | 2022-06-02 | 2023-07-25 | 刘永辉 | 一种普外科医疗工作台 |
KR102568936B1 (ko) * | 2022-11-23 | 2023-08-23 | 서울대학교병원 | 주사기를 이용한 약액 이동 자동화 장치 |
US12090121B1 (en) * | 2024-04-17 | 2024-09-17 | Akbar KHAN | Pneumatic sterile liquid compounding machine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01244759A (ja) * | 1988-03-27 | 1989-09-29 | Anzai Sogyo Kk | 放射線薬液分注装置 |
JPH0360949U (ja) * | 1989-10-17 | 1991-06-14 | ||
WO2010113401A1 (ja) * | 2009-03-31 | 2010-10-07 | パナソニック株式会社 | 薬剤混合装置および薬剤混合方法 |
JP2010279409A (ja) * | 2009-06-02 | 2010-12-16 | Panasonic Corp | 薬液吸入用複合針およびこれを用いた薬液容器並びに薬液吸入方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5911252A (en) * | 1997-04-29 | 1999-06-15 | Cassel; Douglas | Automated syringe filling system for radiographic contrast agents and other injectable substances |
US7163031B2 (en) * | 2004-06-15 | 2007-01-16 | Mallinckrodt Inc. | Automated dispensing system and associated method of use |
US7398802B2 (en) * | 2004-09-02 | 2008-07-15 | Baker James W | System for dispensing biological fluids |
JP4624821B2 (ja) * | 2004-11-01 | 2011-02-02 | 安西メディカル株式会社 | 放射性試料ホルダ |
US7499581B2 (en) * | 2005-02-10 | 2009-03-03 | Forhealth Technologies, Inc. | Vision system to calculate a fluid volume in a container |
NL1028756C1 (nl) * | 2005-04-13 | 2006-10-16 | Medical Dispensing Systems V O | Werkwijze en inrichting voor het bereiden van met vloeistof gevulde produktcontainers. |
US8271138B2 (en) * | 2007-09-12 | 2012-09-18 | Intelligent Hospital Systems Ltd. | Gripper device |
-
2012
- 2012-03-21 WO PCT/JP2012/057201 patent/WO2012133052A1/ja active Application Filing
- 2012-03-21 JP JP2012552977A patent/JP5224013B2/ja active Active
- 2012-03-21 KR KR1020137025051A patent/KR101559219B1/ko active IP Right Grant
- 2012-03-21 US US14/007,320 patent/US20140020790A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01244759A (ja) * | 1988-03-27 | 1989-09-29 | Anzai Sogyo Kk | 放射線薬液分注装置 |
JPH0360949U (ja) * | 1989-10-17 | 1991-06-14 | ||
WO2010113401A1 (ja) * | 2009-03-31 | 2010-10-07 | パナソニック株式会社 | 薬剤混合装置および薬剤混合方法 |
JP2010279409A (ja) * | 2009-06-02 | 2010-12-16 | Panasonic Corp | 薬液吸入用複合針およびこれを用いた薬液容器並びに薬液吸入方法 |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
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US8857476B2 (en) * | 2011-08-08 | 2014-10-14 | Yuyama Mfg. Co., Ltd. | Coinfusion apparatus |
US20140174600A1 (en) * | 2011-08-08 | 2014-06-26 | Yuyama Mfg. Co., Ltd. | Coinfusion apparatus |
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JPWO2014065196A1 (ja) * | 2012-10-25 | 2016-09-08 | 株式会社湯山製作所 | 混注装置 |
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CN104602665A (zh) * | 2012-10-25 | 2015-05-06 | 株式会社汤山制作所 | 混注装置 |
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EP2913042A1 (en) | 2012-10-25 | 2015-09-02 | Yuyama Mfg. Co., Ltd. | Co-infusion device |
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US20150335531A1 (en) * | 2012-10-25 | 2015-11-26 | Yuyama Mfg. Co., Ltd. | Coinfusion apparatus |
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US9474691B2 (en) | 2012-10-25 | 2016-10-25 | Yuyama Mfg. Co., Ltd. | Coinfusion apparatus |
EP2913042B1 (en) | 2012-10-25 | 2019-10-02 | Yuyama Mfg. Co., Ltd. | Co-infusion device |
JP2019205948A (ja) * | 2012-10-25 | 2019-12-05 | 株式会社湯山製作所 | 混注装置 |
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US9801789B2 (en) | 2013-07-11 | 2017-10-31 | Weibel Cds Ag | Device for bringing together substances, in particular for reconstitution of injection solutions |
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WO2015004056A1 (de) * | 2013-07-11 | 2015-01-15 | Weibel Cds Ag | Vorrichtung zur zusammenführung von substanzen, insbesondere zur rekonstitution von injektionslösungen |
US9770388B2 (en) * | 2013-09-19 | 2017-09-26 | Yuyama Mfg. Co., Ltd. | Co-infusion apparatus and co-infusion method |
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JP5224013B2 (ja) | 2013-07-03 |
US20140020790A1 (en) | 2014-01-23 |
KR101559219B1 (ko) | 2015-10-12 |
JPWO2012133052A1 (ja) | 2014-07-28 |
KR20130124983A (ko) | 2013-11-15 |
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