WO2012005200A1 - 光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法 - Google Patents
光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法 Download PDFInfo
- Publication number
- WO2012005200A1 WO2012005200A1 PCT/JP2011/065233 JP2011065233W WO2012005200A1 WO 2012005200 A1 WO2012005200 A1 WO 2012005200A1 JP 2011065233 W JP2011065233 W JP 2011065233W WO 2012005200 A1 WO2012005200 A1 WO 2012005200A1
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- WO
- WIPO (PCT)
- Prior art keywords
- general formula
- bis
- group
- reaction
- benzene derivative
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 33
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title claims description 7
- -1 phosphine-borane compound Chemical class 0.000 claims abstract description 36
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 31
- 125000005843 halogen group Chemical group 0.000 claims abstract description 11
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 6
- 239000007818 Grignard reagent Substances 0.000 claims abstract description 3
- 150000004795 grignard reagents Chemical class 0.000 claims abstract description 3
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 19
- 239000003054 catalyst Substances 0.000 claims description 18
- 229910052723 transition metal Inorganic materials 0.000 claims description 17
- 150000003624 transition metals Chemical class 0.000 claims description 17
- 239000003446 ligand Substances 0.000 claims description 12
- 150000001555 benzenes Chemical class 0.000 abstract description 30
- 125000004432 carbon atom Chemical group C* 0.000 abstract description 18
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract description 8
- 229910000085 borane Inorganic materials 0.000 abstract description 7
- 238000006138 lithiation reaction Methods 0.000 abstract description 5
- 238000006243 chemical reaction Methods 0.000 description 47
- 229910052717 sulfur Inorganic materials 0.000 description 37
- 239000010948 rhodium Substances 0.000 description 36
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 30
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 14
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 14
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 12
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 11
- 229910052799 carbon Inorganic materials 0.000 description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
- 239000000460 chlorine Substances 0.000 description 9
- UPXLDMOZJLPIMF-UHFFFAOYSA-N tert-butyl-methyl-phenylphosphane Chemical compound CC(C)(C)P(C)C1=CC=CC=C1 UPXLDMOZJLPIMF-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 238000005481 NMR spectroscopy Methods 0.000 description 7
- 229910018286 SbF 6 Inorganic materials 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 6
- 229910052794 bromium Inorganic materials 0.000 description 6
- 229910052801 chlorine Inorganic materials 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 229910052703 rhodium Inorganic materials 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 125000002015 acyclic group Chemical group 0.000 description 5
- 238000011914 asymmetric synthesis Methods 0.000 description 5
- 239000012954 diazonium Substances 0.000 description 5
- 150000001989 diazonium salts Chemical class 0.000 description 5
- 235000019439 ethyl acetate Nutrition 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 229910020366 ClO 4 Inorganic materials 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical class ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 4
- 125000002723 alicyclic group Chemical group 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- ZWWQRMFIZFPUAA-UHFFFAOYSA-N dimethyl 2-methylidenebutanedioate Chemical compound COC(=O)CC(=C)C(=O)OC ZWWQRMFIZFPUAA-UHFFFAOYSA-N 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 125000004437 phosphorous atom Chemical group 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 238000000668 atmospheric pressure chemical ionisation mass spectrometry Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 2
- 235000010288 sodium nitrite Nutrition 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- DKFDVEXWZZOMGS-UHFFFAOYSA-N (2-phosphanylphenyl)phosphane Chemical compound PC1=CC=CC=C1P DKFDVEXWZZOMGS-UHFFFAOYSA-N 0.000 description 1
- VYXHVRARDIDEHS-UHFFFAOYSA-N 1,5-cyclooctadiene Chemical compound C1CC=CCCC=C1 VYXHVRARDIDEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004912 1,5-cyclooctadiene Substances 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- AOPBDRUWRLBSDB-UHFFFAOYSA-N 2-bromoaniline Chemical compound NC1=CC=CC=C1Br AOPBDRUWRLBSDB-UHFFFAOYSA-N 0.000 description 1
- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N Cc1c(C)cccc1 Chemical compound Cc1c(C)cccc1 CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000003747 Grignard reaction Methods 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BWJRMVLPCQPWGR-UHFFFAOYSA-N boron;phosphane Chemical compound [B].P BWJRMVLPCQPWGR-UHFFFAOYSA-N 0.000 description 1
- ZKIBBIKDPHAFLN-UHFFFAOYSA-N boronium Chemical class [H][B+]([H])([H])[H] ZKIBBIKDPHAFLN-UHFFFAOYSA-N 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- OYPNACNNLMHIPV-UHFFFAOYSA-N carbon monoxide;chromium;1,2-difluorocyclohexane Chemical compound [Cr].[O+]#[C-].[O+]#[C-].[O+]#[C-].F[C]1[CH][CH][CH][CH][C]1F OYPNACNNLMHIPV-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 239000012973 diazabicyclooctane Substances 0.000 description 1
- 238000006193 diazotization reaction Methods 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 125000005610 enamide group Chemical group 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000006459 hydrosilylation reaction Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- UBJFKNSINUCEAL-UHFFFAOYSA-N lithium;2-methylpropane Chemical compound [Li+].C[C-](C)C UBJFKNSINUCEAL-UHFFFAOYSA-N 0.000 description 1
- NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- IKGHIFGXPVLPFD-LLVKDONJSA-N methyl (2r)-2-acetamido-3-phenylpropanoate Chemical compound COC(=O)[C@H](NC(C)=O)CC1=CC=CC=C1 IKGHIFGXPVLPFD-LLVKDONJSA-N 0.000 description 1
- ZHKPSUPZUILMOG-RXMQYKEDSA-N methyl (3r)-3-acetamidobutanoate Chemical compound COC(=O)C[C@@H](C)NC(C)=O ZHKPSUPZUILMOG-RXMQYKEDSA-N 0.000 description 1
- LZHSHKSQRPIMMV-SNAWJCMRSA-N methyl (e)-3-acetamidobut-2-enoate Chemical compound COC(=O)\C=C(/C)NC(C)=O LZHSHKSQRPIMMV-SNAWJCMRSA-N 0.000 description 1
- USKHBABPFFAKJD-UHFFFAOYSA-N methyl 2-acetamido-3-phenylprop-2-enoate Chemical compound COC(=O)C(NC(C)=O)=CC1=CC=CC=C1 USKHBABPFFAKJD-UHFFFAOYSA-N 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- SJYNFBVQFBRSIB-UHFFFAOYSA-N norbornadiene Chemical compound C1=CC2C=CC1C2 SJYNFBVQFBRSIB-UHFFFAOYSA-N 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NMJASRUOIRRDSX-UHFFFAOYSA-N tert-butyl(dichloro)phosphane Chemical compound CC(C)(C)P(Cl)Cl NMJASRUOIRRDSX-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 150000007934 α,β-unsaturated carboxylic acids Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5449—Polyphosphonium compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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Definitions
- the present invention relates to a method for producing an optically active 1,2-bis (dialkylphosphino) benzene derivative.
- Patent Document 1 proposes a 1,2-bis (dialkylphosphino) benzene derivative.
- This transition metal complex having a benzene derivative as a ligand is a compound having excellent performance as an asymmetric synthesis catalyst.
- Patent Document 1 describes a method for producing the benzene derivative using 1,2-bis (phosphino) benzene as a starting material.
- Non-patent document 1 also proposes a method for producing an optically active 1,2-bis (dialkylphosphino) benzene derivative.
- 1,2-difluorobenzene tricarbonylchromium and bis (dialkylphosphine) boronium salt are used as starting materials.
- an object of the present invention is to provide an industrially advantageous method for producing an optically active 1,2-bis (dialkylphosphino) benzene derivative.
- the present invention provides a method for producing an optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the following general formula (A), wherein the phosphine-borane compound represented by the following general formula (1) is removed. After boraneization, lithiation, and then the reaction product is represented by the general formula R a PX After reacting with an alkyl dihalogenophosphine represented by ' 2 (R a is one of R 1 and R 2 in the following general formula (A) and X' represents a halogen atom), the general formula R b MgX (Where R b is a group different from R a among R 1 and R 2 in the following general formula (A), and X ′′ represents a halogen atom).
- the object is achieved by providing a method for producing a characteristic optically active 1,2-bis (dialkylphosphino) benzene derivative.
- the present invention also provides an asymmetric hydrogenation method using a transition metal complex having a ligand of the optically active 1,2-bis (dialkylphosphino) benzene derivative obtained by the above production method as a catalyst. Is.
- an optically active 1,2-bis (dialkylphosphino) benzene derivative can be produced industrially advantageously without using an expensive compound as a starting material. Moreover, according to the production method of the present invention, even if the alkylphosphino group of the benzene derivative is bulky, it can be easily introduced. Moreover, when an asymmetric hydrogenation reaction is performed using a transition metal complex having a benzene derivative obtained by the production method of the present invention as a ligand as a catalyst, high optical purity and chemical yield can be realized.
- the target product in the production method of the present invention is an optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the general formula (A).
- R 1 and R 2 are alkyl groups having 1 to 8 carbon atoms, and R 1 and R 2 have different carbon numbers.
- R 1 has a larger number of carbon atoms
- the benzene derivative represented by the general formula (A) is an (R, R) isomer.
- R 2 has more carbon atoms
- the benzene derivative represented by the general formula (A) is an (S, S) isomer.
- Examples of the alkyl group having 1 to 8 carbon atoms represented by R 1 and R 2 include acyclic alkyl groups and alicyclic alkyl groups.
- Acyclic alkyl groups include linear alkyl groups and branched alkyl groups.
- Examples of the linear alkyl group include methyl group, ethyl group, n-propyl group, n-butyl group, n-pentyl group, n-hexyl group, n-heptyl group, and n-octyl group having 1 to 8 carbon atoms. Things.
- Examples of the branched alkyl group include those having 3 to 8 carbon atoms such as isopropyl group, isobutyl group, sec-butyl group, tert-butyl group, isoheptyl group, isohexyl group, 1,1,3,3-tetramethylbutyl group Is mentioned.
- Examples of the alicyclic alkyl group include those having 3 to 8 carbon atoms such as a cyclopentyl group and a cyclohexyl group.
- these alkyl groups may be substituted with one or more monovalent substituents (for example, halogen atoms such as fluorine, chlorine, bromine and iodine).
- the difference in carbon number between R 1 and R 2 needs to be at least 1.
- the group having more carbon atoms in R 1 and R 2 is a bulky substituent having steric hindrance.
- the group having more carbon atoms out of R 1 and R 2 is preferably a secondary alkyl group rather than a primary alkyl group, and more preferably a tertiary alkyl group than a secondary alkyl group.
- a preferred alkyl group is a tert-butyl group.
- the benzene derivative represented by the general formula (A) is used as a ligand of a metal complex for an asymmetric synthesis catalyst, considering that a highly asymmetric space is formed, R 1 and R It is preferable that the steric hindrance of 2 has a large difference. That is, it is preferable that one of R 1 and R 2 is a bulky substituent having steric hindrance, that is, a maximal group, while the other is a minimal group. Therefore, the larger the difference in carbon number between R 1 and R 2 , the better. Specifically, the difference in carbon number between R 1 and R 2 is preferably 2 or more, particularly 3 or more, particularly 4 or more.
- the alicyclic alkyl group and the acyclic alkyl group having the same carbon number are more acyclic alkyl groups. preferable.
- a linear alkyl group is preferable to a branched alkyl group.
- the most preferred group as the group having the smaller number of carbon atoms of R 1 and R 2 is a methyl group.
- a group that can be used as a group having a smaller number of carbon atoms is relatively determined in relation to a group having a larger number of carbon atoms.
- R 1 t
- R 2 methyl group
- R 1 methyl group
- R 2 tert-butyl group
- Two R 1 in the general formula (A) may be the same as or different from each other. It is preferable that they are the same. The same applies to the two R 2 .
- Two R 1 and two R 2 In any one of the two —PR 1 R 2 groups in the general formula (A), it is sufficient that R 1 has more carbon atoms or R 2 has more carbon atoms.
- the benzene ring of the benzene derivative represented by the general formula (A) may further have 1 to 4 monovalent substituents.
- substituents include a methyl group, an ethyl group, a propyl group, a butyl group, a methoxy group, an ethoxy group, a trifluoromethyl group, and a 1,4-butylene group.
- the phosphine-borane compound represented by the general formula (1) is deboraneated.
- Deboraneation is a reaction represented by the following reaction formula 1.
- X is a halogen atom such as fluorine, chlorine, bromine or iodine, and is preferably bromine.
- the phosphine-borane compound represented by the general formula (1) which is a starting material in the production method of the present invention, can be synthesized, for example, according to the following reaction formula (i).
- 2-halogenoaniline is first diazotized to form a diazonium salt.
- a commercially available product can be used as the 2-halogenoaniline.
- the diazotization reaction can be performed according to a conventional method, for example, in the presence of sodium nitrite.
- This diazonium salt can be isolated as a tetrafluoroborate.
- the resulting diazonium salt is then reacted with a dialkylphosphine-borane.
- the dialkylphosphine-borane to be reacted with the diazonium salt can be prepared by a known method such as the method described in JP-A No. 2001-253889.
- Dialkylphosphine-borane is deprotonated in an inert solvent such as tetrahydrofuran.
- tetrahydrofuran for deprotonation, for example, butyl lithium is used.
- a dialkylphosphine-borane in a deprotonated state is allowed to act on the diazonium salt.
- This reaction proceeds rapidly in a cryogenic environment or at room temperature.
- a phosphine-borane compound represented by the general formula (1) is generated in the reaction system.
- the dialkylphosphine-borane is S Use the body.
- dialkyl R-type phosphine-borane is used.
- this substituent is reaction formula (i). It can be easily introduced at the stage of 2-halogenoaniline. The introduction of the substituent can be performed according to a conventional method.
- the deboraneation of the phosphine-borane compound represented by the general formula (1) which is the first step of the production method of the present invention, can be performed according to a conventionally known method.
- a base such as 1,4-diazabicyclo [2.2.2] octane (DABCO), N-methylmorpholine, triethylamine, pyrrolidine, and diethylamine in an organic solvent such as THF, hexane, toluene, and dimethoxyethane. It can be carried out.
- DABCO is preferably used as the base.
- the amount of the base used is preferably 1 to 3 moles per mole of the phosphine-borane compound represented by the general formula (1).
- the reaction time can be 0.5 to 5 hours.
- the reaction temperature can be 20-110 ° C.
- Lithiation is a reaction represented by the following reaction formula 2.
- the lithiation can be performed according to a conventionally known method.
- it can be performed using butyl lithium in an organic solvent such as THF, hexane, toluene, dimethoxyethane and the like.
- butyl lithium include n-butyl lithium, sec-butyl lithium, tert-butyl lithium and the like. Among these, sec-butyl lithium is preferable.
- the amount of butyl lithium used is preferably 1.0 to 1.5 moles per mole of the phosphine-borane compound represented by the general formula (1) used in the first step.
- the reaction time can be 0.5 to 5 hours.
- the reaction temperature can be ⁇ 100 to 20 ° C.
- R a PX ′ 2 (R a is a general formula ( It is one of R 1 and R 2 in A), and X ′ represents a halogen atom, and is reacted with an alkyl dihalogenophosphine represented by R a is preferably a group having a larger number of carbon atoms out of R 1 and R 2 .
- Examples of the halogen atom represented by X ′ include fluorine, chlorine, bromine and iodine, with chlorine being preferred.
- the alkyl dihalogenophosphine represented by the general formula R a PX ′ 2 is commercially available.
- reaction in the third step is represented by the following reaction formula 3.
- the reaction in the third step can be performed, for example, in an organic solvent such as THF, hexane, toluene, dimethoxyethane and the like.
- the amount of the alkyl dihalogenophosphine represented by the general formula R a PX ′ 2 is 1.0 to 2.0 with respect to 1 mol of the phosphine-borane compound represented by the general formula (1) used in the first step.
- a molar ratio is preferred.
- the reaction time can be 0.5 to 24 hours.
- the reaction temperature can be ⁇ 100 to 20 ° C.
- the reaction product of the third step is changed to a group of the general formula R b MgX ′′ (R b is a group different from R a among R 1 and R 2 in the general formula (A).
- X ′′ represents a halogen atom).
- the halogen atom represented by X ′′ include fluorine, chlorine, bromine, iodine, etc., and chlorine and bromine are preferable.
- R b is R 2
- the reaction in the fourth step is represented by the following reaction formula 4 It is represented by
- the reaction in the fourth step can be performed according to a conventionally known Grignard reaction.
- it can be carried out in an organic solvent such as THF, hexane, toluene, dimethoxyethane and the like.
- the use amount of the Grignard reagent represented by the general formula R b MgX ′′ is the general formula ( A ratio of 1.0 to 3.0 mol is preferable with respect to 1 mol of the phosphine-borane compound represented by 1).
- the reaction time can be 0.5 to 24 hours.
- the reaction temperature can be 0-100 ° C.
- the reactions in the first to fourth steps are preferably performed under an inert gas.
- the optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the general formula (A), which is the target product is obtained.
- the target benzene derivative is an (R, R) isomer or (S, S) isomer, and after the first to fourth steps, as a component other than the target isomer, the (R, S) isomer or (S, R) A mixture containing a body, for example a meso body, may be obtained.
- the target product is an (R, R) isomer
- two R 1 are the same alkyl group
- two R 2 are the same alkyl group
- the (R, R) isomer and meso isomer A mixture may be obtained.
- the target product can be obtained with high purity.
- This separation may be performed by an ordinary purification method, and recrystallization is usually sufficient.
- this separation can be performed by column separation as necessary.
- the phosphine-borane compound represented by the general formula (1) used as a starting material in the production method of the present invention has one —PR 1 R 2 BH 3 group, and is obtained by deboraneating the compound.
- the compound represented by the general formula (2) has one —PR 1 R 2 group. It is difficult to introduce another -PR 1 R 2 group directly into the X site of these compounds due to steric hindrance due to the bulk of the -PR 1 R 2 group. Therefore, in the present invention, first, one of R 1 and R 2 together with the phosphorus atom is introduced into the compound represented by the general formula (2) having one —PR 1 R 2 group, and then R 1 and introducing the other of R 2. Through such a stepwise process, even if the —PR 1 R 2 group to be introduced is bulky, it can be easily introduced.
- the first to fourth steps can be carried out continuously, so that the optically active 1,2-bis (dialkylphosphino) benzene derivative that is industrially advantageous can be obtained. It has the advantage that it can be obtained.
- the optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the general formula (A) obtained by the production method of the present invention can form a complex with a transition metal as a ligand. It can.
- the transition metal that can form a complex include rhodium, ruthenium, iridium, palladium, nickel, iron, and copper, and rhodium metal is preferable.
- a rhodium complex can be produced by reacting with -diene) rhodium hexafluoroantimonate or bis (cyclooctane-1,5-diene) rhodium tetrafluoroborate.
- rhodium complex examples include [Rh ((S, S)-(A)) (cod)] Cl, [Rh ((S, S)-(A)) (cod)] Br, [ Rh ((S, S)-(A)) (cod)] I, [Rh ((R, R)-(A)) (cod)] Cl, [Rh ((R, R)-(A)) (Cod)] Br, [Rh ((R, R)-(A)) (cod)] I, [Rh ((S, S)-(A)) (cod)] SbF 6 , [Rh ((S , S)-(A)) (cod)] BF 4 , [Rh ((S, S)-(A)) (cod)] ClO 4 , [Rh ((S, S)-(A)) (cod )] PF 6 , [Rh ((S, S)-(A)) (cod) (cod)
- (A) is an optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the general formula (A), cod is 1,5-cyclooctadiene, and nbd is Norbornadiene, Ph represents phenyl.
- a transition metal complex having an optically active 1,2-bis (dialkylphosphino) benzene derivative represented by the general formula (A) as a ligand (hereinafter also referred to as a transition metal complex according to the present invention) is an asymmetric product. It is useful as a synthesis catalyst. Examples of the asymmetric synthesis include asymmetric hydrogenation reaction, asymmetric hydrosilylation reaction, asymmetric Michael addition reaction and the like. These asymmetric synthesis reactions can be performed as usual except that the transition metal complex according to the present invention is used.
- the transition metal complex according to the present invention is particularly suitable as a catalyst in an asymmetric hydrogenation reaction.
- the compound used as a substrate in the asymmetric hydrogenation reaction include compounds having a C ⁇ C double bond or a C ⁇ O double bond containing a prochiral carbon atom.
- the compound include ⁇ dehydroamino acid, ⁇ dehydroamino acid, itaconic acid, enamide, ⁇ -keto ester, enol ester, ⁇ , ⁇ unsaturated carboxylic acid, ⁇ , ⁇ unsaturated carboxylic acid, and the like.
- the molar ratio (substrate / catalyst) between the substrate and the transition metal complex according to the present invention, which is a catalyst is preferably as large as possible, but is practically usually 100 to 100,000. It is preferable.
- a 200 mL four-necked flask was charged with 9.5 mL of concentrated hydrochloric acid, 65 mL of pure water, and 6.0 g (35 mmol) of 2-bromoaniline, and dissolved by heating. After cooling to 0 ° C., a solution of 2.46 g (35.1 mmol) of sodium nitrite previously dissolved in 7.5 mL of pure water was added dropwise over about 10 minutes. At first, the reaction solution which was in the form of an itch became a pale yellow transparent liquid by stirring for 30 minutes. Next, 12.5 g (59.8 mmol) of 42 mass% HBF 4 aqueous solution was added to about When the solution was dropped over a period of time, pale yellow crystals were immediately deposited.
- Example 2-1 will be described in detail below.
- ⁇ -dehydroamino acid 2- (N-acetylamino) -3-phenyl-2-propenoic acid methyl ester 460 mg (2.10 mmol) as a substrate and an asymmetric hydrogenation catalyst in Production Example 2 were used.
- Rhodium (I) ((R, R) -1,2-bis (tert-butylmethylphosphino) benzene) (1,5-cyclooctanediene) hexafluoroantimonate 1.50 mg (2.06 ⁇ 10 6 -3 mmol), 5 times with hydrogen, and 5 mL of degassed dehydrated methanol was added.
- Examples 2-2 to 2-8 an asymmetric hydrogenation reaction was performed in the same manner as in Example 2-1, under the conditions described in Table 1.
- R 1 to R 3 listed in Table 1 correspond to R 1 to R 3 in the general formula showing the substrate in the above reaction formula.
- the amount of the catalyst was the same as that in Example 2-1 so that the molar ratio (S / C) between the substrate and the catalyst described in Table 1 was obtained. The amount of substrate was changed.
- Table 1 summarizes the conditions and results of the asymmetric hydrogenation reactions of Examples 2-1 to 2-8.
- Example 3-1 will be described in detail below.
- Examples 3-2 to 3-7 an asymmetric hydrogenation reaction was performed in the same manner as in Example 3-1, under the conditions described in Table 2.
- R 1 to R 3 listed in Table 2 correspond to R 1 to R 3 in the general formula showing the substrate in the above reaction formula.
- E-form R 1 is H and R 2 is MeOOC
- Z-form R 1 is MeOOC and R 2 is H
- the amount of the catalyst was the same as that of Example 3-1 so that the molar ratio (S / C) of the substrate and the catalyst described in Table 2 was obtained. Changed. Table 2 below summarizes the conditions and results of the asymmetric hydrogenation reaction of Examples 3-1 to 3-7.
- the (R, R) body was produced as the benzene derivative represented by the general formula (A) by the production method of the present invention (Example 1), and then the (R , R) was used as a ligand to produce a transition metal complex (Production Example 2), and an asymmetric hydrogenation method was carried out using the transition metal complex as a catalyst (Examples 2 to 4).
- the production method of the present invention can produce the (S, S) isomer as the benzene derivative represented by the general formula (A), and the (S, S) isomer. It will be apparent to those skilled in the art that high optical purity and chemical yield can be realized when a transition metal complex is produced by using a transition metal complex as a ligand and an asymmetric hydrogenation method is carried out using the transition metal complex as a catalyst.
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Abstract
Description
’2(Raは下記一般式(A)におけるR1及びR2の一方であり、X’はハロゲン原子を示す)で表されるアルキルジハロゲノホスフィンと反応させた後、一般式RbMgX”(Rbは下記一般式(A)におけるR1及びR2のうち、Raとは異なる方の基であり、X”はハ
ロゲン原子を示す)で表されるグリニャール試薬と反応させることを特徴とする光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法を提供することにより、前記目的を達成したものである。
本発明の製造方法における目的物は、前記一般式(A)で表される光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体である。一般式(A)において、R1及び
R2は炭素数1~8のアルキル基であり、R1とR2とでは炭素数が異なる。R1の方が炭素数が多い場合は、一般式(A)で表されるベンゼン誘導体は(R,R)体である。R2の
方が炭素数が多い場合は、一般式(A)で表されるベンゼン誘導体は(S,S)体である。
非環式アルキル基には、直鎖状アルキル基と分岐状アルキル基がある。直鎖状アルキル基としては、メチル基、エチル基、n-プロピル基、n-ブチル基、n-ペンチル基、n-ヘキシル基、n-ヘプチル基、n-オクチル基の炭素数1~8のものが挙げられる。分
岐状アルキル基としては、イソプロピル基、イソブチル基、sec-ブチル基、tert-ブチル基、イソヘプチル基、イソヘキシル基、1,1,3,3-テトラメチルブチル基等の炭素数3~8のものが挙げられる。脂環式アルキル基としては、シクロペンチル基、シクロヘキシル基等の炭素数3~8のものが挙げられる。また、これらのアルキル基は、一個以上の一価の置換基(例えば、フッ素、塩素、臭素、ヨウ素等のハロゲン原子)で置換されたものであってもよい。
ert-ブチル基、R2=メチル基の組み合わせ、R1=メチル基、R2=tert-ブチ
ル基の組み合わせが挙げられる。
同一であることが好ましい。二つのR2についても同様である。二つのR1及び二つのR2
は、一般式(A)における二つの-PR1R2基のいずれにおいても、R1の方が炭素数が
多いか又はR2の方が炭素数が多ければよい。
A)におけるR1及びR2の一方であり、X’はハロゲン原子を示す)で表されるアルキルジハロゲノホスフィンと反応させる。Raは、R1及びR2のうちの炭素数が多い方の基で
あることが好ましい。X’で表されるハロゲン原子としては、フッ素、塩素、臭素、ヨウ素等が挙げられ、塩素が好ましい。一般式RaPX’2で表されるアルキルジハロゲノホスフィンは、市販品として入手可能である。また、工業的にも安価に製造可能である(例えば、特開2002-255983号公報、特開2001-354683号公報等参照)。例えばRaがR1である場合、第3工程の反応は以下の反応式3で表される。
す)で表されるグリニャール試薬と反応させる。X”で表されるハロゲン原子としては、フッ素、塩素、臭素、ヨウ素等が挙げられ、塩素、臭素が好ましい。例えばRbがR2である場合、第4工程の反応は以下の反応式4で表される。
1)で表されるホスフィン-ボラン化合物1モルに対し1.0~3.0モルの割合が好ましい。また、反応時間は0.5~24時間とすることができる。反応温度は0~100℃とすることができる。
成分として(R,S)体又は(S,R)体、例えばメソ体が含有された混合物が得られる場合がある。例えば目的物が(R,R)体であり、二つのR1が同一のアルキル基で且つ
二つのR2が同一のアルキル基である場合には、(R,R)体とメソ体との混合物が得ら
れる場合がある。そのため、必要により精製(a)を行うことにより、該混合物から本発明の目的物である(R,R)体又は(S,S)体を分離すると、目的物を純度よく得ることができる。この分離は、通常の精製方法により行えばよく、通常は再結晶で十分である。また、この分離は、必要に応じてカラム分離により行うことができる。また、精製(a)を行うに当たって、適宜、脱溶媒、洗浄等の精製方法により、精製(a’)を行っておくことが好ましい。
る前記一般式(2)で表される化合物は-PR1R2基を一つ有している。これらの化合物のXの部位に、さらにもう一つの-PR1R2基を直接導入することは、該-PR1R2基の嵩高さに起因する立体障害のために困難である。そこで、本発明では、先ず、-PR1R2基を一つ有する一般式(2)で表される化合物に対し、リン原子と共にR1及びR2の一方を導入し、次にR1及びR2のもう一方を導入する。このような段階的な工程を経ることによって、導入しようとする-PR1R2基が嵩高いものであっても、容易に導入することが可能となる。
第4版(日本化学会編、丸善株式会社発行 第18巻 327~3
53頁)に記載されている方法に従えばよく、例えば、一般式(A)で表される光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体と、ビス(シクロオクタン-1,5-ジエン)ロジウムヘキサフルオロアンチモン酸塩、ビス(シクロオクタン-1,5-ジエン)ロジウムテトラフルオロホウ酸塩等と反応させることにより、ロジウム錯体を製造することができる。
(cod)]BF4、[Rh((R,R)-(A))(cod)]ClO4、[Rh((R,R)-(A))(cod)]PF6、[Rh((R,R)-(A))(cod)]BP
h4、[Rh((S,S)-(A))(nbd)]SbF6、[Rh((S,S)-(A))(nbd)]BF4 、[Rh((S,S)-(A))(ndb)]ClO4 、[Rh((S,S)-(A))(ndb)]PF6 、[Rh((S,S)-(A))(ndb)]
BPh4、[Rh((R,R)-(A))(nbd)]SbF6、[Rh((R,R)-(A))(nbd)]BF4、[Rh((R,R)-(A))(ndb)]ClO4、[Rh((R,R)-(A))(ndb)]PF6、[Rh((R,R)-(A))(ndb)
]BPh4等が挙げられ、本発明では[Rh((S,S)-(A))(cod)]SbF6
又は[Rh((R,R)-(A))(cod)]SbF6が好ましい。尚、上記のロジウム錯体中の(A)は、一般式(A)で表される光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体、codは1,5-シクロオクタジエン、nbdはノルボルナジエン、Phはフェニルを示す。
が挙げられる。不斉水素化反応において、基質と触媒である本発明に係る遷移金属錯体とのモル比(基質/触媒)は、限りなく大きいほうが好ましいが、実用的には通常は100~100,000であることが好ましい。
下記反応式に従い以下の手順で(R)-2-(ボラナト(tert-ブチル)メチルホスフィノ)ブロモベンゼンを合成した。
分かけて滴下したところ、直ちに淡黄色結晶が析出した。30分攪拌した後、グラスフィルターにてろ過、純水30mLで洗浄し、さらにメタノール8mLとエーテル32mLの混合溶液にて洗浄した。その後、減圧乾燥を行い2-ブロモベンゼンジアゾニウムテトラフルオロホウ酸塩4.5g(収率48%)を得た。
-2-(ボラナト(tert-ブチル)メチルホスフィノ)ブロモベンゼンを60mg(収率11%)得た。得られた化合物の分析結果を以下に示す。
1H NMR (500 MHz, CDCl3) δ:
0.20-1.05 (m, 3H), 1.19 (d, J=14.3 Hz, 9H), 1.91 (d,
9.7 Hz, 3H), 7.32 (t, 8.7 Hz, 1H), 7.40 (t, 7.5 Hz, 1H), 7.64 (d, 9.0 Hz, 1H),
8.06 (dd, 12.6,12.9 Hz, 1H);
31P NMR (202 MHz, CDCl3) δ:38.3.
APCI-MS:m/z 275, 273 (M++H).
下記反応式に従い、以下の手順で(R,R)-1,2-ビス(tert-ブチルメチルホスフィノ)ベンゼンを合成した。
分離した後、飽和食塩水で洗浄し、Na2SO4で乾燥した。その後溶媒を濃縮し、残渣の油状物に脱気したメタノールを加えた。生じた結晶をろ過し、少量の冷やしたメタノールで洗浄した後、減圧乾燥し、無色の結晶として、(R,R)-1,2-ビス(tert-ブチルメチルホスフィノ)ベンゼン539mg(収率38%)を得た。得られた化合物の分析結果を以下に示す。
1H NMR (500 MHz, CDCl3) δ: 0.96
(t, J = 6.0 Hz, 18H), 1.23 (t, J = 3.2 Hz, 6H), 7.26-7.35
(m, 2H), 7.48-7.50 (m, 2H)
13C NMR (125 MHz, CDCl3) δ: 5.69
(t, J = 6.0 Hz), 27.24 (t, 8.4 Hz), 30.37 (t,
7.2 Hz), 127.75 (S), 131.47 (S), 144.86 (t, 6.0 Hz)
31P NMR (202 MHz, CDCl3) δ:
-25.20 (s).
APCI-MS:m/z 283 (M++H).
HRMS(TOF): Calcd.for C16H28NaP2: 305.1564,
Found: 305.1472
Mp. 125~126℃
[α]D 24:+222.9
(c, 0.535, EtOAc)
下記反応式に従い、以下の手順でロジウム(I)((R,R)-1,2-ビス(tert-ブチルメチルホスフィノ)ベンゼン)(1,5-シクロオクタンジエン)ヘキサフルオロアンチモネートを合成した。
1H NMR (500 MHz, CDCl3) δ: 1.05
(d, J = 14.3 Hz, 18H), 1.73 (t, J = 8.9 Hz, 6H), 2.20 -
2.25 (m, 4H), 2.50 - 2.57 (m, 2H), 2.65 - 2.69 (m, 2H), 4.89 - 4.90 (m, 2H), 5.99 (t,
J = 6.9 Hz, 2H), 7.74 (t, J = 2.3 Hz, 4H)
31P NMR (202 MHz, CDCl3) δ: 57.59
(d, J = 158 Hz)
HRMS(TOF): Calcd.for C24H40P2Rh: 493.1660,
Found: 493.1574
下記反応式に従い、以下の手順でαデヒドロアミノ酸の不斉水素化を行った。
50mLのガラス製オートクレーブに、基質としてαデヒドロアミノ酸である2-(N-アセチルアミノ)-3-フェニル-2-プロペン酸メチルエステル460mg(2.10mmol)、不斉水添触媒として製造例2で得たロジウム(I)((R,R)-1,2-ビス(tert-ブチルメチルホスフィノ)ベンゼン)(1,5-シクロオクタンジエン)ヘキサフルオロアンチモネート1.50mg(2.06×10-3mmol)を仕込み、水素で5回置換を行い、予め脱気した脱水メタノール5mLを加えた。次いで、水素圧を3気圧として反応を開始した。反応は室温で攪拌しながら行った。反応開始から20分後に、容器内の水素の消費が停止したため反応終了とした。反応液を濃縮した後、残存した白色結晶を酢酸エチルに溶解して、シリカゲルカラムに通した。得られた溶出液をHPLCにて分析したところ、(R)-2-(N-アセチルアミノ)-3-フェニルプロパン酸メチルエステルが99.9%の鏡像異性体過剰率(ee)で得られた。また、1H-N
MRによって分析を行ったところ、化学収率は99%以上であった。尚、HPLC分析の条件は以下の通りである。
(HPLC分析条件)
カラム Daicel Chiralcel OJ,1.0mL/min,ヘキサン:2-プロパノール=9
:1
各エナンチオマーの保持時間 (R)t1=13.3min,(S)t2=19.3min.
尚、表1に記載のR1~R3は、上記反応式における基質を示す一般式中のR1~R3に対応する。また、実施例2-2~2-8においては、表1記載の基質と触媒のモル比(S/C)となるように、触媒の量は実施例2-1と同じとし、
基質の量を変更した。
下記表1に、実施例2-1~2-8の不斉水素化反応の条件及び結果をまとめる。
下記反応式に従い、以下の手順でβデヒドロアミノ酸の不斉水素化を行った。
50mLガラス製オートクレーブに、基質としてβデヒドロアミノ酸である(E)-メチル 3-アセトアミド-2-ブテノエート450.2mg(2.86mmol)、不斉水添触媒として製造例2で得たロジウム(I)((R,R)-1,2-ビス(tert-ブチルメチルホスフィノ)ベンゼン)(1,5-シクロオクタンジエン)ヘキサフルオロアンチモネート2.07mg(2.84×10-3mmol)を仕込み、水素で5回置換を行い、予め脱気した脱水メタノール5mLを加えた。次いで、水素圧を3気圧として反応を開始した。反応は室温で攪拌しながら行った。反応開始から50分後に、容器内の水素の消費が停止したため反応終了とした。反応液を濃縮した後、残存した白色結晶を酢酸エチルに溶解して、シリカゲルカラムに通した。得られた溶出液をGCにて分析したところ、(R)-3-アセトアミドブタン酸メチルエステルが99.6%の鏡像異性体過剰率(ee)で得られた。また、1H-NMRによって分析を行ったところ、化学収率は99%
以上であった。尚、GC分析の条件は以下の通りである。
(GC分析条件)
カラム Varian Chirasil DEX CB,135℃
各エナンチオマーの保持時間 (S)t1=7.6min,(R)t2=8.1min.
尚、表2に記載のR1~R3は、上記反応式における基質を示す一般式中のR1~R3に対応する。実施例3-5及び3-6においては、基質として、E体(R1がHで、R2がMeOOCであるもの)とZ体(R1がMeOOCで、R2がHであるもの)との混合物(モル
比1:1)を用いた。また、実施例3-2~3-7においては、表2記載の基質と触媒のモル比(S/C)となるように、触媒の量は実施例3-1と同じとし、基質の量を変更した。
下記表2に、実施例3-1~3-7の不斉水素化反応の条件及び結果をまとめる。
下記反応式に従い、以下の手順でイタコン酸ジメチルの不斉水素化を行った。
収率は99%以上であった。尚、HPLC分析の条件は以下の通りである。
(HPLC分析条件)
カラム Daicel Chiralcel OD-H,0.8mL/min,ヘキサン:2-プロパノール=
98:2
各エナンチオマーの保持時間 (R)t1=7.9min,(S)t2=12.0min.
れるベンゼン誘導体として(R,R)体を製造した(実施例1)後、該(R,R)体を配位子として用いて遷移金属錯体を製造し(製造例2)、該遷移金属錯体を触媒として用いて不斉水素化方法を行った(実施例2~4)。これらの製造例及び実施例から、本発明の製造方法により、前記一般式(A)で表されるベンゼン誘導体として(S,S)体を製造できることができ、また、該(S,S)体を配位子として用いて遷移金属錯体を製造し、該遷移金属錯体を触媒として用いて不斉水素化方法を行うと高い光学純度及び化学収率を実現できることは、当業者に明らかである。
Claims (2)
- 下記一般式(A)で表される光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法において、
下記一般式(1)で表されるホスフィン-ボラン化合物を脱ボラン化した後、リチオ化し、
次いで、その反応生成物を、一般式RaPX’2(Raは下記一般式(A)におけるR1及びR2の一方であり、X’はハロゲン原子を示す)で表されるアルキルジハロゲノホスフ
ィンと反応させた後、
一般式RbMgX”(Rbは下記一般式(A)におけるR1及びR2のうち、Raとは異な
る方の基であり、X”はハロゲン原子を示す)で表されるグリニャール試薬と反応させることを特徴とする光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法。
- 請求項1記載の製造方法により得られた光学活性な1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体を配位子とする遷移金属錯体を触媒として用いた不斉水素化方法。
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WO2019230479A1 (ja) * | 2018-05-29 | 2019-12-05 | 日本化学工業株式会社 | ホスフィノベンゼンボラン誘導体の製造方法、1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法及び遷移金属錯体 |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000319288A (ja) * | 1999-05-10 | 2000-11-21 | Nippon Chem Ind Co Ltd | 光学活性な1,2−ビス(ジアルキルホスフィノ)ベンゼン誘導体及びその製造方法、並びに該化合物を配位子とするロジウム金属錯体 |
JP2010208993A (ja) * | 2009-03-10 | 2010-09-24 | Nippon Chem Ind Co Ltd | 2,2’−ビス(ジアルキルホスフィノ)ビフェニル化合物及びその製造方法並びに該化合物を配位子とする金属錯体 |
-
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000319288A (ja) * | 1999-05-10 | 2000-11-21 | Nippon Chem Ind Co Ltd | 光学活性な1,2−ビス(ジアルキルホスフィノ)ベンゼン誘導体及びその製造方法、並びに該化合物を配位子とするロジウム金属錯体 |
JP2010208993A (ja) * | 2009-03-10 | 2010-09-24 | Nippon Chem Ind Co Ltd | 2,2’−ビス(ジアルキルホスフィノ)ビフェニル化合物及びその製造方法並びに該化合物を配位子とする金属錯体 |
Non-Patent Citations (2)
Title |
---|
TAMURA, K. ET AL.: "Enantiopure 1,2-Bis(tert- butylmethylphosphino)benzene as a Highly Efficient Ligand in Rhodium-Catalyzed Asymmetric Hydrogenation", ORGANIC LETTERS, vol. 12, no. 19, 2010, pages 4400 - 4403 * |
YAMAMOTO, Y. ET AL.: "Facile Synthesis of Highly Congested 1,2-Diphosphinobenzenes from Bis(phosphine)boronium Salts", ORGANIC LETTERS, vol. 8, no. 26, 2006, pages 6103 - 6106 * |
Cited By (4)
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WO2012176830A1 (ja) * | 2011-06-23 | 2012-12-27 | 日本化学工業株式会社 | 1,2-ビス(ジアルキルホスフィノ)-4,5-(メチレンジオキシ)ベンゼン誘導体、その製造方法及び該1,2-ビス(ジアルキルホスフィノ)-4,5-(メチレンジオキシ)ベンゼン誘導体を配位子とする金属錯体並びに不斉水素化方法 |
JP2013006787A (ja) * | 2011-06-23 | 2013-01-10 | Nippon Chem Ind Co Ltd | 1,2−ビス(ジアルキルホスフィノ)−4,5−(メチレンジオキシ)ベンゼン誘導体、その製造方法及び該1,2−ビス(ジアルキルホスフィノ)−4,5−(メチレンジオキシ)ベンゼン誘導体を配位子とする金属錯体並びに不斉水素化方法 |
US9029571B2 (en) | 2011-06-23 | 2015-05-12 | Nippon Chemical Industrial Co., Ltd. | Device and method for evaluating organic material for organic solar cell |
WO2019230479A1 (ja) * | 2018-05-29 | 2019-12-05 | 日本化学工業株式会社 | ホスフィノベンゼンボラン誘導体の製造方法、1,2-ビス(ジアルキルホスフィノ)ベンゼン誘導体の製造方法及び遷移金属錯体 |
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