WO2011111787A8 - 間葉系幹細胞を含む細胞製剤及びその製造方法 - Google Patents

間葉系幹細胞を含む細胞製剤及びその製造方法 Download PDF

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WO2011111787A8
WO2011111787A8 PCT/JP2011/055683 JP2011055683W WO2011111787A8 WO 2011111787 A8 WO2011111787 A8 WO 2011111787A8 JP 2011055683 W JP2011055683 W JP 2011055683W WO 2011111787 A8 WO2011111787 A8 WO 2011111787A8
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stem cells
mesenchymal stem
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producing same
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WO2011111787A1 (ja
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土屋　利江
辻　紘一郎
加藤　幸夫
金昌 邵
真依子 原
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株式会社ツーセル
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Priority to AU2011225158A priority Critical patent/AU2011225158C1/en
Priority to SG2012066262A priority patent/SG183570A1/en
Priority to US13/583,150 priority patent/US9394521B2/en
Priority to KR1020127026184A priority patent/KR101443478B1/ko
Priority to EP11753445.3A priority patent/EP2545928B1/en
Priority to CN201180012941.1A priority patent/CN102791276B/zh
Priority to DK11753445.3T priority patent/DK2545928T3/en
Priority to CA2792802A priority patent/CA2792802C/en
Priority to JP2012504519A priority patent/JP5804385B2/ja
Publication of WO2011111787A1 publication Critical patent/WO2011111787A1/ja
Publication of WO2011111787A8 publication Critical patent/WO2011111787A8/ja

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Abstract

　免疫抑制能を維持した間葉系幹細胞を含む細胞製剤を無血清又は低血清培養により製造する。ＦＧＦ、ＰＤＧＦ、ＴＧＦ－β、ＨＧＦ、ＥＧＦ、少なくとも１つのリン脂質、及び少なくとも１つの脂肪酸を含有する培地において、間葉系幹細胞を増殖させる増殖工程と、上記増殖工程後の間葉系幹細胞から、免疫抑制能を維持又は向上した間葉系幹細胞をスクリーニングするスクリーニング工程とを包含することを特徴とする間葉系幹細胞を含む細胞製剤の製造方法。
PCT/JP2011/055683 2010-03-10 2011-03-10 間葉系幹細胞を含む細胞製剤及びその製造方法 WO2011111787A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2011225158A AU2011225158C1 (en) 2010-03-10 2011-03-10 Cell preparation containing mesenchymal stem cells, and method for producing same
SG2012066262A SG183570A1 (en) 2010-03-10 2011-03-10 Cell preparation containing mesenchymal stem cells, and method for producing same
US13/583,150 US9394521B2 (en) 2010-03-10 2011-03-10 Cell preparation containing mesenchymal stem cells, and method for producing same
KR1020127026184A KR101443478B1 (ko) 2010-03-10 2011-03-10 간엽계 줄기 세포를 포함한 세포 제제 및 그의 제조 방법
EP11753445.3A EP2545928B1 (en) 2010-03-10 2011-03-10 Cell preparation containing mesenchymal stem cells, and method for producing same
CN201180012941.1A CN102791276B (zh) 2010-03-10 2011-03-10 含有间充质干细胞的细胞制品及其制造方法
DK11753445.3T DK2545928T3 (en) 2010-03-10 2011-03-10 CELL PREPARATION CONTAINING MESENYKYMAL STEM CELLS AND METHOD OF PRODUCING THEREOF
CA2792802A CA2792802C (en) 2010-03-10 2011-03-10 Cell preparation containing mesenchymal stem cells, and method for producing same
JP2012504519A JP5804385B2 (ja) 2010-03-10 2011-03-10 間葉系幹細胞を含む細胞製剤及びその製造方法

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JP2010053179 2010-03-10
JP2010-053179 2010-03-10

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WO2011111787A8 true WO2011111787A8 (ja) 2011-12-01

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US (1) US9394521B2 (ja)
EP (1) EP2545928B1 (ja)
JP (1) JP5804385B2 (ja)
KR (1) KR101443478B1 (ja)
CN (1) CN102791276B (ja)
AU (1) AU2011225158C1 (ja)
CA (1) CA2792802C (ja)
DK (1) DK2545928T3 (ja)
SG (1) SG183570A1 (ja)
WO (1) WO2011111787A1 (ja)

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CN102791276A (zh) 2012-11-21
AU2011225158A1 (en) 2012-11-01
US20120329087A1 (en) 2012-12-27
DK2545928T3 (en) 2016-10-03
AU2011225158C1 (en) 2014-01-23
SG183570A1 (en) 2012-10-30
KR20120137404A (ko) 2012-12-20
EP2545928A1 (en) 2013-01-16
JP5804385B2 (ja) 2015-11-04
JPWO2011111787A1 (ja) 2013-06-27
CA2792802C (en) 2017-10-31
CN102791276B (zh) 2015-03-04
CA2792802A1 (en) 2011-09-15
KR101443478B1 (ko) 2014-09-22
US9394521B2 (en) 2016-07-19
WO2011111787A1 (ja) 2011-09-15

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