WO2011079803A1 - 一种介入式心脏瓣膜 - Google Patents
一种介入式心脏瓣膜 Download PDFInfo
- Publication number
- WO2011079803A1 WO2011079803A1 PCT/CN2010/080497 CN2010080497W WO2011079803A1 WO 2011079803 A1 WO2011079803 A1 WO 2011079803A1 CN 2010080497 W CN2010080497 W CN 2010080497W WO 2011079803 A1 WO2011079803 A1 WO 2011079803A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- valve
- heart valve
- stent
- skirt
- leaflet
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30205—Three-dimensional shapes conical
- A61F2002/3021—Three-dimensional shapes conical frustoconical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9528—Instruments specially adapted for placement or removal of stents or stent-grafts for retrieval of stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9534—Instruments specially adapted for placement or removal of stents or stent-grafts for repositioning of stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0021—Angular shapes square
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0023—Angular shapes triangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/008—Quadric-shaped paraboloidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
Definitions
- the present invention relates to the field of medical device technology, and more particularly to an interventional heart valve.
- the heart's valve is made up of thin, extremely tough sheet-like tissue that opens and closes as the heart contracts and relaxes.
- the normal person's heart beats about 100,000 times a day, and the valve opens and closes 100,000 times. Therefore, the heart's valve must remain flexible, tensioned, and able to withstand the pressure of the heart chamber and the scouring of the blood for a long time.
- Valvular heart disease is one of the most common heart diseases in China, mainly caused by rheumatic fever.
- valve degeneration including calcification and mucus degeneration
- metabolic disorders Damage is also increasing in our country; in addition, congenital valvular disease is one of the common types of congenital heart disease.
- valvular heart disease A considerable number of high-risk diseases of valvular heart disease, such as severe valvular insufficiency, advanced age-adapted surgical valve replacement, advanced tumor and valvular insufficiency, multiple organ dysfunction, and valvular disease, require new minimally invasive interventions. treatment.
- Invasive heart valves are inspired by surgical heart valve replacement surgery.
- percutaneous valve intervention such as percutaneous pulmonary valve stent replacement; percutaneous active valve heart valve replacement; percutaneous mitral valve repair Surgery and percutaneous mitral circumcision came into being. After 2000, they were successfully applied to humans. The preliminary results show that the method is feasible. The effectiveness and risk of interventional therapy must be further evaluated and compared. High-risk patients who cannot tolerate surgery in surgery.
- Percutaneous interventional pulmonary valve implantation; percutaneous active valve heart valve replacement; percutaneous mitral annuloplasty; percutaneous mitral annuloplasty and percutaneous mitral annuloplasty Are all feasible, manifested in the heart function after implantation? Goodness.
- U.S. Patent No. 6,454,799 describes a pelvic dilatation type interventional heart valve in which a bioprosthetic valve is fixed on a plastically deformable stent, which is fixed to the balloon by radial compression of the stent. After the aortic valve is reached, the stent is expanded and fixed by pressurizing the balloon.
- the shortcomings and problems of this kind of balloon-expanded biological valve are: During the stent compression and balloon expansion, the valve leaf tissue structure of the biological valve will be greatly damaged, which seriously affects the service life of the heart valve after implantation.
- the stent of the heart valve is determined by the diameter of the ball. If the size is chosen too small, the valve may be speared or displaced.
- PCT/US2006/018514 describes a self-expanding type of interventional heart valve, which is attached to a self-expanding stent, placed in a catheter of the conveyor, percutaneously implanted, and placed after the aortic valve. Release, fixed to the aortic valve by the structure of the stent itself.
- the shortcomings and problems of this self-expanding biological valve are: The length of the stent is too long, the opening design is not ideal, and the hemodynamics of the left and right coronary veins are easily affected, resulting in cardiac dysfunction; improper translation of the heart valve, Failure to reset will endanger the patient's life; Once the heart valve is implanted, if there is a problem, it cannot be recovered and can only be replaced by surgery.
- Chinese Patent No. CN2726561 describes an invasive prosthetic heart valve in which a valve leaf is sutured on an expandable and compressible tubular stent, used in conjunction with an implant and retrieval device, percutaneous implantation and interventional removal for valve replacement.
- the disadvantages and problems of this heart valve are: The stent is braided by wire. During the process of compression and expansion, the mesh is easily deformed and the radial support force is unstable; there are multiple barbs on the outside of the stent, although The effect of anti-displacement, but the damage to the vessel wall is large.
- the scaffold recovery is easy to tear the blood vessel, which is difficult to achieve the intended recycling purpose;
- the design of the stent takes into account the position of the left and right coronary veins, but only stays 2 to 3 openings, can not eliminate the influence of left and right coronary blood flow, and the heart valve is more difficult to locate when it is placed.
- the present invention provides an interventional heart valve to prevent displacement of the heart valve caused by blood flow impact, and to solve the problem that the heart valve cannot be reset once it is opened.
- the present invention provides the following technical solutions:
- An interventional heart valve including a stent and a valve
- the tubular bracket has a round table structure at one end and an open shape at the other end, and the diameter of the open end is larger than the diameter of one end of the round table;
- the film is attached to one end of the truncated cone structure of the tubular bracket;
- the tubular stent is provided with a heart valve delivery and recovery hole at the top of the open end;
- the truncated cone end of the tubular bracket has a straight line, a circular arc or a combination of a straight line and an arc.
- the open end of the tubular stent has a shape of a bar, and the tubular stent has a structure with a large end and a small intermediate portion.
- the interventional heart valve is a mesh structure composed of a plurality of diamond-shaped stent units.
- the tubular stent has a closed structure except for the two ends.
- the tubular stent gradually decreases from one end of the opening to one end of the circular table.
- the mesh at the opening is larger than the diameter of the left and right coronary veins.
- the mesh of the tubular stent is composed of a stent rod, and the larger the mesh, the thicker the stent rod.
- the open end of the tubular stent is composed of three diamond-shaped meshes, which are flared to the periphery, and the heart valve is transported and recovered in three holes, respectively The tops of the three diamond meshes.
- the tubular stent is a nickel titanium alloy material.
- the interventional heart valve is affixed to the tubular stent by suture stitching.
- the valve is specifically a leaflet and a skirt; the leaflet and the skirt are designed as a unitary structure or a split structure in which the leaflets are sewn on the skirt.
- the leaflet may be a biological tissue, a high molecular material, a metal material or a tissue engineering valve.
- the leaflet and the skirt adopt a split structure
- the skirt is sewn to the grid of the tubular stent, and the leaflets are sewn to the skirt or simultaneously sewn to the skirt and the grid of the stent.
- It can be a biological tissue, a polymer material, a metal material or a tissue engineered valve.
- the skirt is in the shape of a truncated cone formed by three skirt bases of the same trapezoidal shape.
- the base of the leaflet is an arc structure, and a leaflet suture ear is disposed at both ends of the leaflet base, and the leaflet is sewn to the tubular stent And any two adjacent leaflet suture ears are sewn together with the valve suture through the valve, the leaflets and the skirt being stitched along the arc of the base of the leaflet.
- the valve adopts a skirt and a leaflet integrated structure, the valve is sewn on the grid of the tubular stent, and a suture is sewn in the middle of the membrane. Transverse arc.
- the valve may be a biological tissue, a high molecular material, a metal material or a tissue engineering valve.
- the valve is formed by three valve-shaped systems of the same shape;
- both sides are provided with a leaflet suture ear, and the leaflet is sewn into the tubular stent;
- the transverse arc of the valve base is sewn with the stent mesh.
- the position of the aortic valve can be effectively fixed to prevent blood flow.
- the heart valve is displaced by the impact; since the valve is attached to one end of the truncated cone structure of the tubular stent, the left and right coronary veins can be completely avoided, and the hemodynamics of the coronary artery are not affected;
- the top of the open end of the stent is provided with a heart valve delivery and recovery hole, so that the heart valve can be recovered and repositioned by the handle if it is found to be improperly placed during the release process.
- the design of the stent of the invention conforms to the human anatomy structure and can be effectively fixed In the position of the aortic mouth, prevent the heart valve from shifting due to blood flow impact;
- Different stent rod width designs and different stent unit (grid) structures provide a uniform radial support force after heart valve implantation to prevent heart valve displacement due to blood flow impact;
- bracket rod width design Different bracket rod width design, different bracket unit structure, the circumferential shape of the bracket can be properly deformed, and can effectively adhere to the aortic valve portion;
- the unique valve suture design can effectively prevent the risk of leakage around the blood vessels after heart valve implantation
- valve leaflet joint and the joint point can effectively reduce the force exerted on the stent during the operation of the valve and increase the durability of the stent;
- the unique biological valve leaflet shape design increases the durability during valve operation; the smaller size (18F) of the conveyor matched with the present invention can effectively reduce the stimulation and damage to the blood vessel, and the head end of the conveyor can be bent by the handle , in line with the physiological structure of the aortic arch, to avoid damage to the aortic arch.
- FIG. 1 is a front view of a heart valve according to a first embodiment of the present invention
- FIG. 2 is a top view of a heart valve in a valve closed state according to Embodiment 1 of the present invention
- FIG. 3 is a top view of a heart valve in an open state of a valve according to Embodiment 1 of the present invention.
- FIG. 4 is a partial enlarged view of a bracket according to Embodiment 1 of the present invention.
- FIG. 5 is a schematic view showing a state of compression of a heart valve according to Embodiment 1 of the present invention
- FIG. 6 is a schematic structural view showing a design of a leaflet according to Embodiment 1 of the present invention
- FIG. 7 is a schematic structural view of a skirt provided according to Embodiment 1 of the present invention.
- FIG. 8 is a folded view of a leaflet according to Embodiment 1 of the present invention.
- FIG. 9 is a perspective view showing a suture of a leaflet and a skirt according to a first embodiment of the present invention
- FIG. 10 is a perspective view of a skirt stitching according to a first embodiment of the present invention
- FIG. 11 is a schematic view showing a suture track of a leaflet, a skirt and a bracket according to Embodiment 1 of the present invention
- FIG. 12 is a schematic view showing the positional relationship between the heart valve and the coronary ostium after implantation of the heart valve according to the first embodiment of the present invention
- Figure 13 is a front elevational view of a heart valve according to a second embodiment of the present invention.
- FIG. 14 is a schematic view showing a valve design according to a second embodiment of the present invention
- FIG. 16 is a schematic view showing a valve design according to a second embodiment of the present invention
- FIG. 17 is a valve suture development diagram according to a second embodiment of the present invention.
- Figure 18 is a perspective view of a valve suture according to a second embodiment of the present invention.
- Figure 19 is a schematic view showing the suture track of the valve and the stent according to the second embodiment of the present invention
- Figure 20 is a schematic view showing the positional relationship between the valve and the coronary valve after implantation of the heart valve according to the second embodiment of the present invention.
- the present invention discloses an interventional heart valve to prevent displacement of the heart valve caused by blood flow impact, and to solve the problem that the heart valve cannot be reset once it is opened.
- FIG. 1 is a front view of a heart valve according to a first embodiment of the present invention.
- FIG. 2 is a top view of a heart valve in a valve closed state according to an embodiment of the present invention
- FIG. 3 is a first embodiment of the present invention.
- FIG. 4 is a partially enlarged view of a stent according to a first embodiment of the present invention
- FIG. 5 is a schematic view showing a compressed state of a cardiac membrane according to a first embodiment of the present invention.
- 1 is a tubular stent
- 2 is a leaflet
- 3 is a skirt
- 4 is a heart valve delivery and recovery hole
- 5 is a leaflet edge shape
- 6 is a skirt and a stent suture track
- 7 is a leaflet closure line
- 8 is the suture of the leaflet and the stent
- 9 is the first stent unit
- 10 is the second stent unit
- 11 is the third stent unit.
- the interventional heart valve provided by the invention comprises a tubular stent 1, a leaflet 2 and a skirt
- the tubular bracket 1 has a round table structure at one end and an open shape at the other end, and the diameter of the open end is larger than the diameter of one end of the round table; the round table end of the tubular bracket has a straight line of the round bus. Arc or a combination of a line and an arc.
- valve 2 is sewn on the skirt 3, wherein the valve edge shape 5 is an orphan, and the skirt 3 is sewn to one end of the truncated cone structure of the tubular stent 1, wherein the reference number 6 is the skirt and the stent suture track. ;
- the tubular stent 1 is provided with a heart valve delivery and recovery hole 4 at the top of the open end.
- valve 2 is closed in a closed state with three leaflet closure lines 7 bisecting the entire circumference; the valve 2 is tubular when in the open state.
- the end of the tubular stent is open-shaped, and the diameter of the open end is larger than the diameter of one end of the truncated cone, it can be effectively fixed at the position of the aortic valve to prevent the heart from being caused by blood flow impact.
- Valve displacement since the valve is attached to one end of the truncated cone structure of the tubular stent, the left and right coronary veins can be completely avoided, and the hemodynamics of the coronary artery are not affected; since the tubular stent is open
- the top of one end of the shape is provided with a heart valve delivery and recovery hole, so that the heart valve can be recovered and repositioned at any time by the handle if it is found to be improperly placed during the release process.
- the open end of the above-mentioned tubular stent 1 is flared or petal shaped, and the unique stent opening is provided. Taking into account the connection to the delivery system, if the heart valve is completely released, if the position is found to be improperly placed or the valve is not functioning properly, the handle can be completely recovered, the heart valve can be repositioned or a new heart valve replaced.
- the tubular bracket 1 is a grid structure composed of a plurality of diamonds or other symmetrical figures, each grid is referred to as a bracket unit, and the tubular bracket 1 provided by the present invention is composed of a plurality of bracket units.
- the tubular bracket 1 has a mesh gradually decreasing from one end of the opening to the end of the circular table, that is, the closer to the open end, the larger the bracket unit, and the larger the bracket unit at the open end of the horn.
- the first bracket unit 9, the second bracket unit 10 and the third bracket unit 11 wherein the first bracket unit 9 is a bracket unit at the bottom of the tubular bracket 1, and the third bracket unit 11 is a horn open end.
- the top bracket unit and the second bracket unit 10 are bracket units in the middle position of the tubular bracket 1. As is apparent from the figure, the grid of the third bracket unit 11 is the largest, and the grid of the first bracket unit 9 is the smallest. The mesh size of the second bracket unit 10 is between the first bracket unit 9 and the third bracket unit 11.
- bracket units are listed in this embodiment.
- an incremental grid structure may be used, and the same grid structure may be used, as long as the grid structure at the open end is ensured.
- the mesh structure of the straight pipe end is the smallest, and the present invention is not limited to the above three bracket units.
- the mesh of the open end that is, the mesh of the third stent unit 11 is larger than the diameter of the left and right coronary veins, so that the left and right coronary veins can be avoided.
- the grid of the tubular bracket is surrounded by the bracket rods, that is, each bracket unit is a closed unit surrounded by the bracket rods, and the larger the grid, the thicker the bracket rods.
- Different stent rod width design, different stent unit structure provide a uniform radial support force after heart valve implantation, prevent the heart valve displacement caused by blood flow impact; can also make the circumferential shape of the stent can be properly deformed, Can effectively adhere to the aortic valve portion.
- the tubular bracket structure is designed to shrink layer by layer, the metal density of the bracket from the top to the bottom is different, only 3 points to the opening of the horn, in order to provide a consistent support force, so the design is higher.
- the thicker the rod width of the stent it can be understood that the larger the grid is, the thicker the stent rod is.
- the open end of the tubular stent 1 is composed of three diamond-shaped stent units, which are flared outwardly, and the heart valve delivery and recovery holes 4 are respectively disposed at the tops of the three diamond-shaped stent units.
- the type bracket 1 is laser-engraved from a nickel-titanium alloy tube, and is formed into a designed structure by heat treatment, shaping, sandblasting, polishing, and the like.
- FIG. 6 is a schematic structural view of a leaflet according to a first embodiment of the present invention
- FIG. 7 is a schematic view of a skirt structure according to Embodiment 1 of the present invention
- FIG. 8 is a leaflet provided by Embodiment 1 of the present invention.
- FIG. 9 is a perspective view showing a suture of a leaflet and a skirt according to a first embodiment of the present invention
- FIG. 10 is a perspective view of a skirt, which is provided in a first embodiment of the present invention
- FIG. Schematic diagram of the stitching path of the skirt and the bracket are schematic structural view of a leaflet according to a first embodiment of the present invention
- FIG. 7 is a schematic view of a skirt structure according to Embodiment 1 of the present invention
- FIG. 8 is a leaflet provided by Embodiment 1 of the present invention.
- FIG. 9 is a perspective view showing a suture of a leaflet and a skirt according to a first embodiment of the present invention
- 2 is the leaflet
- 3 is the skirt
- 12 is the leaflet suture ear
- 13 is the leaflet and skirt suture
- 14 is the skirt and skirt suture
- 15 is the valve and valve suture.
- the base of the valve 2 has an arc-shaped structure, and a leaflet suture ear 12 is provided at both ends of the base of the valve (ie, both ends of the arc in which the arc and the line meet), and the leaflet suture ear 12 is sewn.
- a leaflet suture ear 12 is provided at both ends of the base of the valve (ie, both ends of the arc in which the arc and the line meet), and the leaflet suture ear 12 is sewn.
- the tubular stent 1 and any adjacent two leaflet suture ears 12 are sewn together by their position in contact with the base of the valve (ie, the position of the valve and the valve suture 15 )
- the valve 2 A bottom arc is sewn to the skirt 3.
- Valve 2 can choose biological tissue: such as bovine pericardium, pig pericardium, pig heart valve, horse pericardium, bovine jugular vein, etc.; also can choose polymer materials: such as PU, e-PTFE, etc.; also choose metal materials: such as after special Processed Nitinol sheets; tissue engineered valves are also available.
- biological tissue such as bovine pericardium, pig pericardium, pig heart valve, horse pericardium, bovine jugular vein, etc.
- polymer materials such as PU, e-PTFE, etc.
- metal materials such as after special Processed Nitinol sheets
- tissue engineered valves are also available.
- the skirt 3 is a truncated cone formed by three skirt bases of the same trapezoidal shape. Adjacent sides of any two skirt bases are sewn together, reference numeral 14 is the skirt and skirt stitching, and the skirt 3 can be selected from biological tissues: such as beef heart bag, pig heart bag, pig heart valve, horse heart bag, cow The jugular vein; etc.; also can choose polymer materials: such as PU, e-PTFE, etc.; also can choose metal materials: such as Nitinol sheets made by special process; also can choose tissue engineering valve.
- biological tissues such as beef heart bag, pig heart bag, pig heart valve, horse heart bag, cow The jugular vein; etc.; also can choose polymer materials: such as PU, e-PTFE, etc.; also can choose metal materials: such as Nitinol sheets made by special process; also can choose tissue engineering valve.
- the interventional heart valve provided by the invention has various specifications, the diameters are respectively 20 to 29 mm, the diameter of the inflow port is 23 to 31 mm, the diameter of the outflow port is 35 to 50 mm, and the height of the heart valve is 35 to 50 mm.
- FIG. 12 is a schematic diagram showing the positional relationship between the heart valve and the coronary valve after implantation of the heart valve according to the first embodiment of the present invention.
- 1 is a tubular stent
- 16 is a left coronary artery
- 17 is a right coronary artery
- 18 is a main artery.
- the heart valve is placed in the position of the aortic valve mouth 18. Since the valve head of the heart valve provided by the present invention is not provided with a valve at the opening of the horn, and the mesh (ie, the bracket unit) is large, the mesh is much larger than the left and right crowns. ⁇ Yong 16, 17, so that the left and right coronary arteries 16, 17 can be avoided.
- FIG. 13 is a front view of a heart valve according to a second embodiment of the present invention
- FIG. 14 is a schematic view showing a state of compression of a heart valve according to a second embodiment of the present invention
- FIG. 15 is a valve design according to a second embodiment of the present invention.
- FIG. 16 is a valve-folding diagram of a second embodiment of the present invention.
- FIG. 18 is a perspective view of a valve suture according to a second embodiment of the present invention.
- FIG. FIG. 20 is a schematic view showing the positional relationship between the valve and the stent after the heart valve is implanted according to the second embodiment of the present invention.
- 1 tubular stent
- 2 membrane
- 3 is heart valve delivery and recovery hole
- 4 valve and stent suture
- 5 is stent and valve suture trajectory
- 6 is valve leaf suture ear
- 7 is valve and valve Suture
- 8 is the left coronary artery
- 9 is the right coronary artery
- 10 is the aortic valve.
- the structure of the tubular stent 1 is the same as in the first embodiment, and the heart valve delivery and recovery hole 3 is also provided at the open end, and will not be described again.
- the valve 2 is formed by three valve bodies of the same irregular shape, and the overall shape is the same as the shape of the valve in which the leaflets and the skirt are sewn, and the valve 2 is designed as a one-piece structure;
- both sides are provided with a leaflet suture ear 6, and the leaflet suture ear 6 is sewn on the tubular stent 1;
- a transverse arc is sewn in the middle of the valve by a suture.
- the transverse valve suture is sutured to the tubular stent 1 and the stent and valve suture trajectory 5 is the transverse arc.
- valve and valve suture 7 is the stitching position.
- the present invention can be placed into the aortic valve position as follows:
- the heart valve Place the heart valve into the conveyor, cut a small incision in the chest, and insert a sheath with an inner diameter larger than the conveyor from the apex. Under the guidance of the DSA device, place a ball in the aortic valve, the ball. After the pressure is applied, the valve of the lesion is opened, and after the ball is reached, the conveyor with the heart valve is placed through the sheath, and after the DSA is guided, the heart valve is released after reaching the position of the aortic valve. At the same time, the conveyor is withdrawn from the body and the puncture is sutured.
- the end of the tubular stent has an open shape, and the diameter of the open end is larger than the diameter of one end of the truncated cone, which can be effectively fixed at the position of the aortic valve to prevent displacement of the heart valve caused by blood flow impact. Since the valve is attached to one end of the truncated cone structure of the tubular stent, the left and right coronary veins can be completely avoided, and the hemodynamics of the coronary artery are not affected; since the tubular stent has an open end The top of the heart is provided with a heart valve delivery and recovery hole, so that the heart valve can be recovered and repositioned at any time during the release process if it is found to be improperly placed.
- the invention can adopt the integrated design of the leaflet and the skirt, or can adopt the split design of the two, and is set by stitching.
- the design of the stent of the invention conforms to the anatomical structure of the human body, and can be effectively fixed at the position of the aortic mouth to prevent displacement of the heart valve caused by blood flow impact;
- Different stent rod width designs and different stent unit (grid) structures provide a uniform radial support force after heart valve implantation to prevent heart valve displacement due to blood flow impact;
- bracket rod width design Different bracket rod width design, different bracket unit structure, the circumferential shape of the bracket can be properly deformed, and can effectively adhere to the aortic valve portion;
- the unique valve suture design can effectively prevent the risk of leakage around the blood vessels after heart valve implantation
- valve leaflet joint and the joint point can effectively reduce the force exerted on the stent during the operation of the valve and increase the durability of the stent;
- the unique biological valve leaflet shape design increases the durability during valve operation; the smaller size (18F) of the conveyor matched with the present invention can effectively reduce the stimulation and damage to the blood vessel, and the head end of the conveyor can be bent by the handle , in line with the physiological structure of the aortic arch, to avoid damage to the aortic arch.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012546343A JP5788409B2 (ja) | 2009-12-30 | 2010-12-30 | 低侵襲性心臓弁 |
ES10840590T ES2918373T3 (es) | 2009-12-30 | 2010-12-30 | Válvula cardiaca invasiva |
EP10840590.3A EP2520249B1 (en) | 2009-12-30 | 2010-12-30 | Invasive cardiac valve |
US13/519,930 US9095431B2 (en) | 2009-12-30 | 2010-12-30 | Invasive cardiac valve |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102480657A CN102113921A (zh) | 2009-12-30 | 2009-12-30 | 一种介入式心脏瓣膜 |
CN200910248065.7 | 2009-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011079803A1 true WO2011079803A1 (zh) | 2011-07-07 |
Family
ID=44212926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2010/080497 WO2011079803A1 (zh) | 2009-12-30 | 2010-12-30 | 一种介入式心脏瓣膜 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9095431B2 (zh) |
EP (1) | EP2520249B1 (zh) |
JP (1) | JP5788409B2 (zh) |
CN (1) | CN102113921A (zh) |
ES (1) | ES2918373T3 (zh) |
WO (1) | WO2011079803A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103006352A (zh) * | 2012-12-24 | 2013-04-03 | 杭州启明医疗器械有限公司 | 一种假体瓣膜及假体瓣膜装置 |
EP2787924B1 (en) | 2011-12-05 | 2017-09-20 | Medtronic Inc. | Transcatheter valve having reduced seam exposure |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7914569B2 (en) * | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
US8652201B2 (en) * | 2006-04-26 | 2014-02-18 | The Cleveland Clinic Foundation | Apparatus and method for treating cardiovascular diseases |
DE202008018589U1 (de) | 2007-09-26 | 2016-03-14 | St. Jude Medical, Inc. | Zusammenfaltbare Herzklappenprothesen |
US9532868B2 (en) | 2007-09-28 | 2017-01-03 | St. Jude Medical, Inc. | Collapsible-expandable prosthetic heart valves with structures for clamping native tissue |
EP3025681B1 (en) | 2008-07-15 | 2017-02-01 | St. Jude Medical, Inc. | Collabsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US10321998B2 (en) | 2010-09-23 | 2019-06-18 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
US9579193B2 (en) | 2010-09-23 | 2017-02-28 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
RS60735B1 (sr) | 2010-10-05 | 2020-09-30 | Edwards Lifesciences Corp | Protetski srčani zalistak |
US9155619B2 (en) | 2011-02-25 | 2015-10-13 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery apparatus |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9549817B2 (en) | 2011-09-22 | 2017-01-24 | Transmural Systems Llc | Devices, systems and methods for repairing lumenal systems |
CN102764169B (zh) * | 2012-04-19 | 2015-07-29 | 杭州启明医疗器械有限公司 | 人工心脏瓣膜及其瓣膜支架 |
US10206775B2 (en) | 2012-08-13 | 2019-02-19 | Medtronic, Inc. | Heart valve prosthesis |
CN102949253B (zh) * | 2012-10-16 | 2015-12-30 | 北京迈迪顶峰医疗科技有限公司 | 一种支架瓣膜及其输送装置 |
US10918479B2 (en) | 2013-02-25 | 2021-02-16 | Shanghai Microport Cardioflow Medtech Co., Ltd. | Heart valve prosthesis |
CN104000672B (zh) * | 2013-02-25 | 2016-06-15 | 上海微创心通医疗科技有限公司 | 心脏瓣膜假体 |
BR112015021968B1 (pt) * | 2013-03-15 | 2022-03-22 | Navigate Cardiac Structures, Inc. | Montagem de válvula cardíaca bioprotética |
CN103190968B (zh) * | 2013-03-18 | 2015-06-17 | 杭州启明医疗器械有限公司 | 一种支架以及具有该支架的安装稳固的人造瓣膜置换装置 |
CN103431931B (zh) * | 2013-06-25 | 2015-10-28 | 杭州启明医疗器械有限公司 | 肺动脉支架及具有该肺动脉支架的肺动脉瓣膜置换装置 |
US10117743B2 (en) * | 2013-07-01 | 2018-11-06 | St. Jude Medical, Cardiology Division, Inc. | Hybrid orientation paravalvular sealing stent |
WO2015027008A1 (en) * | 2013-08-22 | 2015-02-26 | St. Jude Medical, Cardiology Division, Inc. | Stent with alternative cell shapes |
EP3043745B1 (en) | 2013-09-12 | 2020-10-21 | St. Jude Medical, Cardiology Division, Inc. | Stent designs for prosthetic heart valves |
US9662202B2 (en) * | 2013-10-24 | 2017-05-30 | Medtronic, Inc. | Heart valve prosthesis |
US9913715B2 (en) | 2013-11-06 | 2018-03-13 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak sealing mechanism |
EP3073964A1 (en) * | 2013-11-27 | 2016-10-05 | St. Jude Medical, Cardiology Division, Inc. | Cuff stitching reinforcement |
ES2771900T3 (es) * | 2013-12-19 | 2020-07-07 | St Jude Medical Cardiology Div Inc | Fijaciones de valva-manguito para válvula cardíaca protésica |
US10058315B2 (en) | 2014-03-27 | 2018-08-28 | Transmural Systems Llc | Devices and methods for closure of transvascular or transcameral access ports |
CN109893298A (zh) * | 2014-12-19 | 2019-06-18 | 国立研究开发法人国立循环器病研究中心 | 人工瓣膜 |
CN107252363B (zh) * | 2015-03-26 | 2020-04-28 | 杭州启明医疗器械股份有限公司 | 减小压缩长度的瓣膜支架及具有该瓣膜支架的瓣膜置换装置 |
CN107157622B (zh) * | 2015-03-26 | 2019-12-17 | 杭州启明医疗器械股份有限公司 | 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置 |
CN104758091B (zh) * | 2015-04-20 | 2018-09-21 | 上海纽脉医疗科技有限公司 | 一种介入式人工心脏瓣膜的支架及其制备方法 |
JP6869967B2 (ja) | 2015-09-15 | 2021-05-12 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービスThe United States Of America, As Represented By The Secretary, Department Of Health And Human Service | 経皮的グレン並びにフォンタン手術を実施するための装置及び方法 |
CN105287051B (zh) * | 2015-09-30 | 2017-10-10 | 复旦大学附属中山医院 | 一种经外周动脉途径植入的人工主动脉瓣环系统 |
US9872765B2 (en) * | 2015-10-12 | 2018-01-23 | Venus Medtech (Hangzhou) Inc | Mitral valve assembly |
US11833034B2 (en) | 2016-01-13 | 2023-12-05 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
CN105726167A (zh) * | 2016-02-02 | 2016-07-06 | 上海纽脉医疗科技有限公司 | 一种介入式人工心脏瓣膜 |
CA3041455A1 (en) | 2016-10-19 | 2018-05-03 | Piotr Chodor | Stent of aortic valve implanted transcatheterly |
PL423186A1 (pl) * | 2017-10-18 | 2019-04-23 | Chodor Piotr | Stent zastawki aortalnej |
CN109996581B (zh) | 2016-11-21 | 2021-10-15 | 内奥瓦斯克迪亚拉公司 | 用于快速收回经导管心脏瓣膜递送系统的方法和系统 |
CN108245281A (zh) | 2016-12-28 | 2018-07-06 | 上海微创心通医疗科技有限公司 | 瓣膜假体 |
CN106890035A (zh) * | 2017-04-17 | 2017-06-27 | 乐普(北京)医疗器械股份有限公司 | 一种经导管植入式主动脉瓣膜装置 |
CN108720972A (zh) * | 2017-04-19 | 2018-11-02 | 北京航空航天大学 | 一种避免冠状动脉遮挡的自扩张介入瓣膜支架 |
EP3672530A4 (en) | 2017-08-25 | 2021-04-14 | Neovasc Tiara Inc. | SEQUENTIALLY INSERTED TRANSCATHETER MITRAL VALVE PROSTHESIS |
CN109966023A (zh) * | 2017-12-28 | 2019-07-05 | 上海微创心通医疗科技有限公司 | 心脏瓣膜假体及其支架 |
CN110101486B (zh) * | 2018-02-01 | 2024-02-27 | 上海微创心通医疗科技有限公司 | 心脏瓣膜假体及其输送器 |
CN108125732A (zh) * | 2018-02-06 | 2018-06-08 | 北京迈迪顶峰医疗科技有限公司 | 人工瓣膜及人工瓣膜装置 |
CN108542554B (zh) * | 2018-03-05 | 2021-07-02 | 沛嘉医疗科技(苏州)有限公司 | 经导管心脏主动脉瓣膜支架 |
CN109124829A (zh) * | 2018-06-29 | 2019-01-04 | 金仕生物科技(常熟)有限公司 | 一种经导管主动脉瓣膜及其制作方法 |
AU2019353156A1 (en) | 2018-10-05 | 2021-05-13 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
WO2020093172A1 (en) | 2018-11-08 | 2020-05-14 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
US11471282B2 (en) | 2019-03-19 | 2022-10-18 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
CN109985274A (zh) * | 2019-03-28 | 2019-07-09 | 北京航空航天大学 | 具有再生功能的组织工程经导管瓣膜裙体及其制备方法 |
CA3135753C (en) | 2019-04-01 | 2023-10-24 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
AU2020279750B2 (en) | 2019-05-20 | 2023-07-13 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
US11484407B2 (en) * | 2020-01-07 | 2022-11-01 | Highlife Sas | Transcatheter valve prosthesis |
CN114081669A (zh) * | 2020-08-25 | 2022-02-25 | 北京市普惠生物医学工程有限公司 | 人工瓣膜及瓣膜输送系统 |
CN116098740A (zh) * | 2021-06-24 | 2023-05-12 | 杭州启明医疗器械股份有限公司 | 全回收人工心脏瓣膜系统 |
WO2024107820A1 (en) * | 2022-11-18 | 2024-05-23 | Edwards Lifesciences Corporation | Vascular stents and support structures for prosthetic heart valves |
CN116616962B (zh) * | 2023-07-24 | 2023-12-19 | 乐普(北京)医疗器械股份有限公司 | 免缝合人工心脏瓣膜 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
CN2726561Y (zh) | 2004-09-08 | 2005-09-21 | 王蓉珍 | 介入式人工心脏瓣膜 |
WO2006124649A2 (en) * | 2005-05-13 | 2006-11-23 | Corevalve, Inc. | Heart valve prothesis and methods of manufacture and use |
CN1961847A (zh) * | 2005-11-09 | 2007-05-16 | 温宁 | 人工心脏支架瓣膜及其输放装置 |
CN1961845A (zh) * | 2005-11-09 | 2007-05-16 | 温宁 | 人工心脏支架瓣膜 |
CN101243999A (zh) * | 2008-03-05 | 2008-08-20 | 中国人民解放军第二军医大学 | 可回收可调整位置的带瓣膜主动脉支架 |
CN201168081Y (zh) * | 2008-03-05 | 2008-12-24 | 中国人民解放军第二军医大学 | 可回收可调整位置的带瓣膜主动脉支架 |
US20090216312A1 (en) * | 2008-02-26 | 2009-08-27 | Helmut Straubinger | Stent for the Positioning and Anchoring of a Valvular Prosthesis in an Implantation Site in the Heart of a Patient |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2683449A1 (fr) * | 1991-11-08 | 1993-05-14 | Cardon Alain | Endoprothese pour implantation transluminale. |
US8828078B2 (en) * | 2003-12-23 | 2014-09-09 | Sadra Medical, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
DE102005051849B4 (de) * | 2005-10-28 | 2010-01-21 | JenaValve Technology Inc., Wilmington | Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen |
US8052750B2 (en) * | 2006-09-19 | 2011-11-08 | Medtronic Ventor Technologies Ltd | Valve prosthesis fixation techniques using sandwiching |
AU2007351026B2 (en) * | 2007-04-13 | 2012-04-05 | Jenavalve Technology Inc. | Medical device for treating a heart valve insufficiency or stenosis |
-
2009
- 2009-12-30 CN CN2009102480657A patent/CN102113921A/zh active Pending
-
2010
- 2010-12-30 US US13/519,930 patent/US9095431B2/en active Active
- 2010-12-30 WO PCT/CN2010/080497 patent/WO2011079803A1/zh active Application Filing
- 2010-12-30 ES ES10840590T patent/ES2918373T3/es active Active
- 2010-12-30 EP EP10840590.3A patent/EP2520249B1/en active Active
- 2010-12-30 JP JP2012546343A patent/JP5788409B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
CN2726561Y (zh) | 2004-09-08 | 2005-09-21 | 王蓉珍 | 介入式人工心脏瓣膜 |
WO2006124649A2 (en) * | 2005-05-13 | 2006-11-23 | Corevalve, Inc. | Heart valve prothesis and methods of manufacture and use |
CN1961847A (zh) * | 2005-11-09 | 2007-05-16 | 温宁 | 人工心脏支架瓣膜及其输放装置 |
CN1961845A (zh) * | 2005-11-09 | 2007-05-16 | 温宁 | 人工心脏支架瓣膜 |
US20090216312A1 (en) * | 2008-02-26 | 2009-08-27 | Helmut Straubinger | Stent for the Positioning and Anchoring of a Valvular Prosthesis in an Implantation Site in the Heart of a Patient |
CN101243999A (zh) * | 2008-03-05 | 2008-08-20 | 中国人民解放军第二军医大学 | 可回收可调整位置的带瓣膜主动脉支架 |
CN201168081Y (zh) * | 2008-03-05 | 2008-12-24 | 中国人民解放军第二军医大学 | 可回收可调整位置的带瓣膜主动脉支架 |
Non-Patent Citations (1)
Title |
---|
See also references of EP2520249A4 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2787924B1 (en) | 2011-12-05 | 2017-09-20 | Medtronic Inc. | Transcatheter valve having reduced seam exposure |
US11284995B2 (en) | 2011-12-05 | 2022-03-29 | Medtronic, Inc. | Transcatheter valve having reduced seam exposure |
EP2787924B2 (en) † | 2011-12-05 | 2023-07-26 | Medtronic Inc. | Transcatheter valve having reduced seam exposure |
CN103006352A (zh) * | 2012-12-24 | 2013-04-03 | 杭州启明医疗器械有限公司 | 一种假体瓣膜及假体瓣膜装置 |
Also Published As
Publication number | Publication date |
---|---|
JP5788409B2 (ja) | 2015-09-30 |
ES2918373T3 (es) | 2022-07-15 |
CN102113921A (zh) | 2011-07-06 |
US20120316642A1 (en) | 2012-12-13 |
EP2520249B1 (en) | 2022-03-30 |
JP2013516198A (ja) | 2013-05-13 |
EP2520249A1 (en) | 2012-11-07 |
US9095431B2 (en) | 2015-08-04 |
EP2520249A4 (en) | 2017-12-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2011079803A1 (zh) | 一种介入式心脏瓣膜 | |
JP7314203B2 (ja) | 僧帽弁アセンブリ | |
JP7036556B2 (ja) | 心臓の僧帽弁及び三尖弁の交換のための弁付きステント | |
CN109199641B (zh) | 一种带固定件的人工瓣膜假体 | |
EP3711716B1 (en) | Valve stent, valve prosthesis and delivery device | |
CN106510902B (zh) | 用于二尖瓣反流治疗装置的方法和设计 | |
CN107613907B (zh) | 心脏瓣膜组件 | |
WO2017121194A1 (zh) | 一种具有定位环的经导管输送主动脉瓣瓣膜装置 | |
KR101617052B1 (ko) | 스텐트 부착 심장 판막 장치 | |
US9737401B2 (en) | Methods for anchoring a device at a native heart valve annulus | |
WO2017121193A1 (zh) | 一种具有圆弧状定位杆的经导管输送主动脉瓣瓣膜装置 | |
JP7150924B2 (ja) | 経カテーテル肺動脈球弁アセンブリ | |
JP2020532402A (ja) | 人工弁尖器具 | |
WO2019128583A1 (zh) | 心脏瓣膜假体及其支架 | |
US10918479B2 (en) | Heart valve prosthesis | |
CN111110403A (zh) | 一种带锚定环的心脏瓣膜装置及其使用方法 | |
WO2023082579A1 (zh) | 一种人工心脏瓣膜 | |
CN212382790U (zh) | 一种带锚定环的心脏瓣膜装置 | |
US20220192831A1 (en) | Adaptable devices and systems for docking in circulatory system and methods thereof | |
CN212788787U (zh) | 一种人工心脏瓣膜 | |
CN116196151B (zh) | 一种可预置的人工生物主动脉瓣 | |
CN219021749U (zh) | 一种人工心脏瓣膜 | |
EP3960129A1 (en) | Prosthetic heart valve | |
WO2022267210A1 (zh) | 一种人工心脏瓣膜及其输送系统 | |
CN117100458A (zh) | 一种含选择性分布倒刺的瓣膜假体装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10840590 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012546343 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13519930 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010840590 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1870/KOLNP/2012 Country of ref document: IN |