WO2011034341A3 - 저분자량 히알루론산 제조 방법 - Google Patents

저분자량 히알루론산 제조 방법 Download PDF

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Publication number
WO2011034341A3
WO2011034341A3 PCT/KR2010/006312 KR2010006312W WO2011034341A3 WO 2011034341 A3 WO2011034341 A3 WO 2011034341A3 KR 2010006312 W KR2010006312 W KR 2010006312W WO 2011034341 A3 WO2011034341 A3 WO 2011034341A3
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WO
WIPO (PCT)
Prior art keywords
molecular weight
hyaluronic acid
weight hyaluronic
low molecular
present
Prior art date
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PCT/KR2010/006312
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English (en)
French (fr)
Other versions
WO2011034341A2 (ko
Inventor
강대중
임종혁
강재훈
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일동제약주식회사
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43759170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2011034341(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 일동제약주식회사 filed Critical 일동제약주식회사
Priority to ES10817410T priority Critical patent/ES2535625T5/es
Priority to JP2012529671A priority patent/JP5750442B2/ja
Priority to BR112012005816-9A priority patent/BR112012005816B1/pt
Priority to EP10817410.3A priority patent/EP2479194B2/en
Priority to CN201080041200.1A priority patent/CN102630231B/zh
Publication of WO2011034341A2 publication Critical patent/WO2011034341A2/ko
Publication of WO2011034341A3 publication Critical patent/WO2011034341A3/ko
Priority to US13/419,004 priority patent/US20120232261A1/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Sustainable Development (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 스트렙토코크스 속 ID9102에 의해 생산된 고분자 히알루론산을 저분자 히알루론산으로 만드는 방법에 관한 것이다. 구체적으로, 본발명은 고분자 히알루론산과 활성탄을 일정 분해 조건 하에서 반응시켜 히알루론산 고유의 특성은 유지하고 히알루론산 분자량은 일정하게 줄이는 방법에 관한 것이다. 본 발명에 따른 고분자 히알루론산의 저분자화 방법은 ph 처리의 조건이나 각 종 반응 촉매 그리고 가열 등의 복잡한 추가 처리 조건을 필요로 하는 공지의 방법에 비하여 공정이 편리하고 투입된 재료의 제거를 위한 재처리의 불편함이 없으며 동시에 오히려 불순물을 제거하는 효과까지 동반하는 것이기 때문에 간편하고 경제적이며 고순도로 저분자 히알루론산을 생산할 수 있다. 본 발명에 따른 저분자화 방법은 활성탄을 이용한 반응 조건의 변경에 따라 저분자 히알루론산의 분자량을 다양하게 조절할 수 있는 장점이 있다. 본발명에 따라 생산되는 저분자 히알루론산은 히알루론산 고유의 특성은 유지한 채 의약품 규격에 적합하게 제조될 수 있으며, 또한 화장품이나 식품용으로 사용되는 규격으로 적합하게 제조 될 수 있다.
PCT/KR2010/006312 2009-09-15 2010-09-15 저분자량 히알루론산 제조 방법 WO2011034341A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES10817410T ES2535625T5 (es) 2009-09-15 2010-09-15 Método para fabricar ácido hialurónico de bajo peso molecular
JP2012529671A JP5750442B2 (ja) 2009-09-15 2010-09-15 低分子量ヒアルロン酸製造方法
BR112012005816-9A BR112012005816B1 (pt) 2009-09-15 2010-09-15 método para a fabricação de ácido hialurônico de baixo peso molecular
EP10817410.3A EP2479194B2 (en) 2009-09-15 2010-09-15 Method for manufacturing low molecular weight hyaluronic acid
CN201080041200.1A CN102630231B (zh) 2009-09-15 2010-09-15 低分子量透明质酸的制造方法
US13/419,004 US20120232261A1 (en) 2009-09-15 2012-03-13 Method for manufacturing low molecular weight hyaluronic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090087185A KR101132114B1 (ko) 2009-09-15 2009-09-15 히알루론산의 분자량을 조절하는 방법
KR10-2009-0087185 2009-09-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/419,004 Continuation US20120232261A1 (en) 2009-09-15 2012-03-13 Method for manufacturing low molecular weight hyaluronic acid

Publications (2)

Publication Number Publication Date
WO2011034341A2 WO2011034341A2 (ko) 2011-03-24
WO2011034341A3 true WO2011034341A3 (ko) 2011-07-14

Family

ID=43759170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/006312 WO2011034341A2 (ko) 2009-09-15 2010-09-15 저분자량 히알루론산 제조 방법

Country Status (8)

Country Link
US (1) US20120232261A1 (ko)
EP (1) EP2479194B2 (ko)
JP (1) JP5750442B2 (ko)
KR (1) KR101132114B1 (ko)
CN (1) CN102630231B (ko)
BR (1) BR112012005816B1 (ko)
ES (1) ES2535625T5 (ko)
WO (1) WO2011034341A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101322227B1 (ko) 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법
KR101598329B1 (ko) * 2013-03-20 2016-02-29 일동제약주식회사 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물
EP2910255A1 (en) 2014-02-19 2015-08-26 MedSkin Solutions Dr. Suwelack AG Methods for the production of biopolymers with defined average molecular weight
CN105777937A (zh) * 2016-03-22 2016-07-20 山东众山生物科技有限公司 一种从透明质酸发酵液中制备透明质酸钠的方法
KR102240239B1 (ko) 2019-04-23 2021-04-14 (주)티엠비 저분자량 히알루론산의 제조방법 및 이로부터 제조된 저분자량 히알루론산
CN111040048A (zh) * 2019-12-21 2020-04-21 南京汉欣医药科技有限公司 一种超低分子量透明质酸及其制备方法
KR102451308B1 (ko) 2022-02-21 2022-10-07 이광미 금속 티오옥토일 히알루로네이트 복합체 및 이의 제조 방법

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US4278593A (en) * 1979-01-11 1981-07-14 Nobuhiko Katsunuma Glucocorticoid sparing factor and process for the production of the same
US5756721A (en) * 1991-01-16 1998-05-26 National Starch And Chemical Investment Holding Corporation Purification of polysaccharides
JP3113056B2 (ja) * 1992-03-13 2000-11-27 鐘紡株式会社 養毛料
JPH10195107A (ja) * 1997-01-10 1998-07-28 Shiseido Co Ltd オリゴ硫酸化ヒアルロン酸
JP2002360292A (ja) * 2001-06-11 2002-12-17 Medicaraise Corp 低分子ヒアルロン酸の抽出方法及び低分子ヒアルロン酸を含有する食品
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Also Published As

Publication number Publication date
BR112012005816A2 (pt) 2020-08-25
ES2535625T3 (es) 2015-05-13
WO2011034341A2 (ko) 2011-03-24
ES2535625T5 (es) 2019-01-10
JP2013504679A (ja) 2013-02-07
CN102630231B (zh) 2015-05-27
KR101132114B1 (ko) 2012-04-05
CN102630231A (zh) 2012-08-08
EP2479194A4 (en) 2013-09-11
EP2479194A2 (en) 2012-07-25
EP2479194B2 (en) 2018-08-01
JP5750442B2 (ja) 2015-07-22
KR20110029492A (ko) 2011-03-23
BR112012005816B1 (pt) 2021-03-09
EP2479194B1 (en) 2015-01-28
US20120232261A1 (en) 2012-09-13

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