WO2009075258A1 - 経皮吸収製剤 - Google Patents

経皮吸収製剤 Download PDF

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Publication number
WO2009075258A1
WO2009075258A1 PCT/JP2008/072318 JP2008072318W WO2009075258A1 WO 2009075258 A1 WO2009075258 A1 WO 2009075258A1 JP 2008072318 W JP2008072318 W JP 2008072318W WO 2009075258 A1 WO2009075258 A1 WO 2009075258A1
Authority
WO
WIPO (PCT)
Prior art keywords
tape
absorptive preparation
transdermally absorptive
bisphosphonate
weight
Prior art date
Application number
PCT/JP2008/072318
Other languages
English (en)
French (fr)
Inventor
Akira Yamamoto
Toshiyasu Sakane
Hidemasa Katsumi
Fumio Kamiyama
Ying-Shu Quan
Original Assignee
Cosmed Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmed Pharmaceutical Co., Ltd. filed Critical Cosmed Pharmaceutical Co., Ltd.
Priority to EP08860823A priority Critical patent/EP2233142A4/en
Priority to US12/746,594 priority patent/US20100266670A1/en
Priority to JP2009545406A priority patent/JP5328672B2/ja
Priority to CN200880117612A priority patent/CN101873859A/zh
Publication of WO2009075258A1 publication Critical patent/WO2009075258A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

　本発明は、経皮吸収性に優れ、安全性及び使用性の高い、骨粗しょう症、骨ペイジェット病、悪性腫瘍に伴う高カルシウム血症等の骨カルシウム代謝疾患治療に適したテープ型経皮吸収製剤を提供する。 　ビスフォスフォネート又はその誘導体を含有することを特徴とするテープ型経皮吸収製剤であり、アクリル酸５０～８８重量％、アクリル酸２－エチルヘキシル８～４０重量％及び極性モノマー（アクリル酸を除く）１～４２重量％よりなるアクリル系共重合体１００重量部と多価アルコール１５０～６００重量部と医薬的に有効量のビスフォスフォネートからなる粘着剤層が支持シートの一面に積層されているテープ型経皮吸収製剤が好ましい。  
PCT/JP2008/072318 2007-12-10 2008-12-09 経皮吸収製剤 WO2009075258A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08860823A EP2233142A4 (en) 2007-12-10 2008-12-09 PREPARATION OF TRANSDERMAL ABSORPTION
US12/746,594 US20100266670A1 (en) 2007-12-10 2008-12-09 Transdermally absorptive preparation
JP2009545406A JP5328672B2 (ja) 2007-12-10 2008-12-09 経皮吸収製剤
CN200880117612A CN101873859A (zh) 2007-12-10 2008-12-09 经皮吸收贴剂

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007341687 2007-12-10
JP2007-341687 2007-12-10
JP2008046818 2008-01-31
JP2008-046818 2008-01-31
JP2008293889 2008-10-22
JP2008-293889 2008-10-22

Publications (1)

Publication Number Publication Date
WO2009075258A1 true WO2009075258A1 (ja) 2009-06-18

Family

ID=40755500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072318 WO2009075258A1 (ja) 2007-12-10 2008-12-09 経皮吸収製剤

Country Status (6)

Country Link
US (1) US20100266670A1 (ja)
EP (1) EP2233142A4 (ja)
JP (1) JP5328672B2 (ja)
KR (1) KR20100095577A (ja)
CN (1) CN101873859A (ja)
WO (1) WO2009075258A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011136283A1 (ja) 2010-04-28 2011-11-03 久光製薬株式会社 皮膚刺激抑制剤及び経皮吸収製剤
WO2011136288A1 (ja) 2010-04-28 2011-11-03 久光製薬株式会社 ドネペジル含有経皮吸収製剤
WO2013061969A1 (ja) 2011-10-26 2013-05-02 久光製薬株式会社 オキシブチニン含有経皮吸収製剤
JP2014070039A (ja) * 2012-09-28 2014-04-21 Yakult Honsha Co Ltd 皮膚透過速度コントロール剤
JP2014516969A (ja) * 2011-05-25 2014-07-17 アリスジェン ソシエテ アノニム 薬物の粘膜投与
JP2018048173A (ja) * 2010-09-03 2018-03-29 株式会社 メドレックス 皮膚貼付用粘着シートの製造方法
CN111171375A (zh) * 2020-02-04 2020-05-19 华月圆 一种pe用新型抗菌抗静电添加剂及其制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069150A2 (en) * 2010-11-22 2012-05-31 Powerpore Gmbh Cytoprotectant agents for the prevention of drug-associated side-effects
US20170216430A1 (en) * 2014-08-04 2017-08-03 Nitto Denko Corporation Immune-induction-promoting composition including nuclear receptor ligand, and vaccine pharmaceutical composition
US10471141B2 (en) * 2014-09-03 2019-11-12 Nitto Denko Corporation Bisphosphonate-containing vaccine pharmaceutical composition for humoral immunity
US9987361B1 (en) 2014-12-29 2018-06-05 Noven Pharmaceuticals, Inc. Compositions and method for sustained drug delivery by active transdermal technology

Citations (14)

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Publication number Priority date Publication date Assignee Title
JPS61221118A (ja) * 1985-03-28 1986-10-01 Nitto Electric Ind Co Ltd 医薬製剤
JPH04217919A (ja) * 1990-04-27 1992-08-07 Sekisui Chem Co Ltd エペリゾンまたはトルペリゾン経皮吸収製剤
JPH04360827A (ja) * 1991-06-07 1992-12-14 Sekisui Chem Co Ltd 経皮吸収貼付剤
JPH0769869A (ja) * 1993-08-27 1995-03-14 Nitto Denko Corp ブニトロロール含有貼付製剤
JPH0899820A (ja) * 1994-09-30 1996-04-16 Kose Corp 皮膚外用剤
JPH09176049A (ja) * 1995-10-24 1997-07-08 Lintec Corp ゲル製剤組成物及びゲル製剤
JPH115733A (ja) * 1997-06-17 1999-01-12 Sekisui Chem Co Ltd 医療用粘着剤及び医療用貼付剤
JP2000517324A (ja) 1996-09-04 2000-12-26 エルティエス ローマン テラピー―ズュステーメ アーゲ エストリオールを含む組み合せ作用物質を有する経皮吸収治療システム
JP2004250330A (ja) 2002-02-14 2004-09-09 Ono Pharmaceut Co Ltd 経皮投与製剤
JP2004250423A (ja) 2002-02-14 2004-09-09 Yamanouchi Pharmaceut Co Ltd 経皮投与製剤
WO2005011662A1 (ja) * 2003-07-31 2005-02-10 Hisamitsu Pharmaceutical Co., Inc. 貼付剤
JP2005170883A (ja) * 2003-12-12 2005-06-30 National Food Research Institute エマルションの作製方法及びエマルション
JP2006213658A (ja) 2005-02-04 2006-08-17 Hisamitsu Pharmaceut Co Inc 骨粗鬆症治療用外用剤
JP2006290858A (ja) * 2005-04-11 2006-10-26 Kosumedei:Kk 皮膚用粘着剤組成物、生体電極用粘着剤組成物、経皮吸収用粘着剤組成物、皮膚用テープ、生体電極及び経皮吸収製剤

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US5252586A (en) * 1990-09-28 1993-10-12 The Du Pont Merck Pharmaceutical Company Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents
AU662155B2 (en) * 1991-05-10 1995-08-24 Celtrix Pharmaceuticals, Inc. Targeted delivery of bone growth factors
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US6436386B1 (en) * 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
CN1633300A (zh) * 2002-02-14 2005-06-29 山之内制药株式会社 透皮制剂
EP2062584A1 (en) * 2006-09-11 2009-05-27 Kyukyu Pharmaceutical Co., Ltd. Adhesive preparation

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61221118A (ja) * 1985-03-28 1986-10-01 Nitto Electric Ind Co Ltd 医薬製剤
JPH04217919A (ja) * 1990-04-27 1992-08-07 Sekisui Chem Co Ltd エペリゾンまたはトルペリゾン経皮吸収製剤
JPH04360827A (ja) * 1991-06-07 1992-12-14 Sekisui Chem Co Ltd 経皮吸収貼付剤
JPH0769869A (ja) * 1993-08-27 1995-03-14 Nitto Denko Corp ブニトロロール含有貼付製剤
JPH0899820A (ja) * 1994-09-30 1996-04-16 Kose Corp 皮膚外用剤
JPH09176049A (ja) * 1995-10-24 1997-07-08 Lintec Corp ゲル製剤組成物及びゲル製剤
JP2000517324A (ja) 1996-09-04 2000-12-26 エルティエス ローマン テラピー―ズュステーメ アーゲ エストリオールを含む組み合せ作用物質を有する経皮吸収治療システム
JPH115733A (ja) * 1997-06-17 1999-01-12 Sekisui Chem Co Ltd 医療用粘着剤及び医療用貼付剤
JP2004250330A (ja) 2002-02-14 2004-09-09 Ono Pharmaceut Co Ltd 経皮投与製剤
JP2004250423A (ja) 2002-02-14 2004-09-09 Yamanouchi Pharmaceut Co Ltd 経皮投与製剤
WO2005011662A1 (ja) * 2003-07-31 2005-02-10 Hisamitsu Pharmaceutical Co., Inc. 貼付剤
JP2005170883A (ja) * 2003-12-12 2005-06-30 National Food Research Institute エマルションの作製方法及びエマルション
JP2006213658A (ja) 2005-02-04 2006-08-17 Hisamitsu Pharmaceut Co Inc 骨粗鬆症治療用外用剤
JP2006290858A (ja) * 2005-04-11 2006-10-26 Kosumedei:Kk 皮膚用粘着剤組成物、生体電極用粘着剤組成物、経皮吸収用粘着剤組成物、皮膚用テープ、生体電極及び経皮吸収製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2233142A4

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2564873A4 (en) * 2010-04-28 2013-11-06 Hisamitsu Pharmaceutical Co MEANS FOR THE SUPPRESSION OF SKIN IRRITATIONS AND TRANSDERMAL PREPARATION THEREOF
JP5665861B2 (ja) * 2010-04-28 2015-02-04 久光製薬株式会社 ドネペジル含有経皮吸収製剤
CN102858372A (zh) * 2010-04-28 2013-01-02 久光制药株式会社 皮肤刺激抑制剂和经皮吸收制剂
EP2564848A1 (en) * 2010-04-28 2013-03-06 Hisamitsu Pharmaceutical Co., Inc. Transdermally absorbable donepezil-containing preparation
EP2564873A1 (en) * 2010-04-28 2013-03-06 Hisamitsu Pharmaceutical Co., Inc. Skin irritation suppressant and transdermal preparation
TWI501790B (zh) * 2010-04-28 2015-10-01 Hisamitsu Pharmaceutical Co Contains percutaneous absorption preparations from Donepezil
WO2011136288A1 (ja) 2010-04-28 2011-11-03 久光製薬株式会社 ドネペジル含有経皮吸収製剤
EP2564848A4 (en) * 2010-04-28 2013-11-06 Hisamitsu Pharmaceutical Co TRANSDERMAL ABSORBABLE DON-PEPPER PREPARATION
WO2011136283A1 (ja) 2010-04-28 2011-11-03 久光製薬株式会社 皮膚刺激抑制剤及び経皮吸収製剤
JP2018048173A (ja) * 2010-09-03 2018-03-29 株式会社 メドレックス 皮膚貼付用粘着シートの製造方法
JP2014516969A (ja) * 2011-05-25 2014-07-17 アリスジェン ソシエテ アノニム 薬物の粘膜投与
US9533048B2 (en) 2011-05-25 2017-01-03 Arisgen Sa Mucosal delivery of drugs
WO2013061969A1 (ja) 2011-10-26 2013-05-02 久光製薬株式会社 オキシブチニン含有経皮吸収製剤
JP2014070039A (ja) * 2012-09-28 2014-04-21 Yakult Honsha Co Ltd 皮膚透過速度コントロール剤
CN111171375A (zh) * 2020-02-04 2020-05-19 华月圆 一种pe用新型抗菌抗静电添加剂及其制备方法

Also Published As

Publication number Publication date
EP2233142A4 (en) 2011-01-05
US20100266670A1 (en) 2010-10-21
EP2233142A1 (en) 2010-09-29
JPWO2009075258A1 (ja) 2011-04-28
CN101873859A (zh) 2010-10-27
JP5328672B2 (ja) 2013-10-30
KR20100095577A (ko) 2010-08-31

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