WO2011132966A3 - 경피 흡수 제제 - Google Patents

경피 흡수 제제 Download PDF

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Publication number
WO2011132966A3
WO2011132966A3 PCT/KR2011/002887 KR2011002887W WO2011132966A3 WO 2011132966 A3 WO2011132966 A3 WO 2011132966A3 KR 2011002887 W KR2011002887 W KR 2011002887W WO 2011132966 A3 WO2011132966 A3 WO 2011132966A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
transdermal absorption
absorption preparation
present
layer
Prior art date
Application number
PCT/KR2011/002887
Other languages
English (en)
French (fr)
Other versions
WO2011132966A2 (ko
Inventor
최영권
김정주
김성수
이정식
박성민
Original Assignee
아이큐어(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아이큐어(주) filed Critical 아이큐어(주)
Priority to CN201180020562.7A priority Critical patent/CN102946873B/zh
Priority to US13/642,960 priority patent/US20130165875A1/en
Priority to EP11772254.6A priority patent/EP2561865A4/en
Priority to JP2013506085A priority patent/JP5658353B2/ja
Publication of WO2011132966A2 publication Critical patent/WO2011132966A2/ko
Publication of WO2011132966A3 publication Critical patent/WO2011132966A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)

Abstract

본 발명은 경피 흡수 제제에 관한 것이다. 본 발명은 약물 함유 점착층, 약물 보호층 및 박리층을 포함하여 이루어지는 경피 흡수 제제로서, 상기 약물 함유 점착층은 로피니롤 또는 그의 염, 고무, 점착 부여 수지, 산화방지제, 및 경피 흡수 촉진제를 포함하는 것을 특징으로 하는 경피 흡수 제제를 제공한다. 또한 본 발명은 약물 함유 점착층, 약물 보호층 및 박리층을 포함하여 이루어지는 경피 흡수 제제로서, 상기 약물 함유 점착층은 로피니롤 또는 그의 염, 아크릴계 점착제, 결정화 방지제, 및 경피 흡수 촉진제를 포함하는 것을 특징으로 하는 경피 흡수 제제를 제공한다. 본 발명의 경피 흡수 제제를 파킨슨 병 또는 하지 불안 증후군 치료용으로 사용할 경우, 초기 혈중 농도 상승에 따른 부작용이 없으면서도 약물의 피부 투과 성능이 우수하다는 장점이 있다.
PCT/KR2011/002887 2010-04-23 2011-04-21 경피 흡수 제제 WO2011132966A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201180020562.7A CN102946873B (zh) 2010-04-23 2011-04-21 经皮吸收制剂
US13/642,960 US20130165875A1 (en) 2010-04-23 2011-04-21 Transdermal absorption preparation
EP11772254.6A EP2561865A4 (en) 2010-04-23 2011-04-21 PREPARATION FOR TRANSDERMAL ABSORPTION
JP2013506085A JP5658353B2 (ja) 2010-04-23 2011-04-21 経皮吸収製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100038184A KR101292768B1 (ko) 2010-04-23 2010-04-23 경피 흡수 제제
KR10-2010-0038184 2010-04-23

Publications (2)

Publication Number Publication Date
WO2011132966A2 WO2011132966A2 (ko) 2011-10-27
WO2011132966A3 true WO2011132966A3 (ko) 2012-04-12

Family

ID=44834668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/002887 WO2011132966A2 (ko) 2010-04-23 2011-04-21 경피 흡수 제제

Country Status (6)

Country Link
US (1) US20130165875A1 (ko)
EP (1) EP2561865A4 (ko)
JP (1) JP5658353B2 (ko)
KR (1) KR101292768B1 (ko)
CN (1) CN102946873B (ko)
WO (1) WO2011132966A2 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2641651T3 (es) 2011-05-31 2017-11-10 Hisamitsu Pharmaceutical Co., Inc. Parche que contiene ropinirol y envase para el mismo
ES2657016T3 (es) * 2011-05-31 2018-03-01 Hisamitsu Pharmaceutical Co., Inc. Parche cutáneo adhesivo que contiene ropinirol y producto envasado del mismo
JP6104173B2 (ja) * 2011-12-01 2017-03-29 帝國製薬株式会社 ロピニロール含有貼付剤
GB201120908D0 (en) * 2011-12-06 2012-01-18 Reckitt Benckiser Healthcare Patch containing non-steroidal anti-inflammatory drug
WO2014084311A1 (ja) * 2012-11-30 2014-06-05 帝國製薬株式会社 ロピニロール含有貼付剤
US10292955B2 (en) 2013-04-04 2019-05-21 Hyundai Pharm Co., Ltd. Composition for external use preparation with improved transdermal permeability
JP5415645B1 (ja) * 2013-06-28 2014-02-12 久光製薬株式会社 貼付剤の製造方法、貼付剤及び包装体
KR101485822B1 (ko) * 2014-01-22 2015-01-23 주식회사 대웅제약 도네페질 또는 그의 염을 함유하는 경피흡수제제
JP6373061B2 (ja) * 2014-05-23 2018-08-15 帝國製薬株式会社 経皮投与製剤
WO2016052522A1 (ja) * 2014-09-30 2016-04-07 ニプロ株式会社 経皮投与製剤及び包装体
WO2016103956A1 (ja) * 2014-12-25 2016-06-30 ニプロ株式会社 経皮投与製剤
KR101937073B1 (ko) * 2015-04-15 2019-01-09 히사미쓰 세이야꾸 가부시키가이샤 로피니롤 함유 첩부제
EP3297620A4 (en) * 2015-06-27 2019-01-09 Shenox Pharmaceuticals, LLC TRANSDERMAL DELIVERY SYSTEM FOR KETAMINE
US10561603B2 (en) 2015-06-29 2020-02-18 Sekisui Chemical Co., Ltd. Core-shell structure and topical agent
KR101717699B1 (ko) * 2016-02-11 2017-03-17 아이큐어 주식회사 카타플라스마제용 자외선 경화형 하이드로젤 수지, 하이드로젤 및 이를 포함하는 카타플라스마제
WO2018080214A1 (ko) * 2016-10-31 2018-05-03 신신제약 주식회사 수면장애 치료용 경피흡수제제
KR102499141B1 (ko) * 2016-10-31 2023-02-13 신신제약 주식회사 수면장애 치료용 경피흡수제제
KR102024996B1 (ko) * 2017-12-27 2019-09-25 동아에스티 주식회사 도네페질을 함유하는 치매 치료용 경피흡수제제
KR102042456B1 (ko) * 2018-03-22 2019-11-08 크리스탈지노믹스(주) 경피흡수제제
KR102455157B1 (ko) * 2018-10-31 2022-10-17 신신제약 주식회사 로피니롤 경피흡수제
WO2021054257A1 (ja) * 2019-09-18 2021-03-25 久光製薬株式会社 ロピニロール含有貼付剤及びロピニロールの皮膚透過性向上方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039136A1 (en) * 1995-06-06 1996-12-12 Smithkline Beecham Plc Transdermal formulation comprising ropinirole
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
US20040253299A1 (en) * 2001-07-30 2004-12-16 Cornelia Beier Transdermal therapeutic system (reservoir-tts) for using pramipexole and ropinirole
US20050175680A1 (en) * 2002-06-25 2005-08-11 Acrux Dds Pty Ltd. Transdermal delivery rate control using amorphous pharmaceutical compositions
US6929801B2 (en) * 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
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US7344733B2 (en) * 2001-07-28 2008-03-18 Hexal Ag Matrix controlled transdermal therapeutic system for the use of pramipexole and ropinirole
US20090035377A1 (en) * 2003-07-21 2009-02-05 Noven Pharmaceuticals, Inc. Composition and method for controlling drug delivery from silicone adhesive blends

Family Cites Families (3)

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DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
DE10338174A1 (de) * 2003-08-20 2005-03-24 Lts Lohmann Therapie-Systeme Ag Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit
ES2661767T3 (es) * 2008-02-27 2018-04-03 Hisamitsu Pharmaceutical Co., Inc. Parche adhesivo para la piel y producto envasado

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039136A1 (en) * 1995-06-06 1996-12-12 Smithkline Beecham Plc Transdermal formulation comprising ropinirole
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
US6929801B2 (en) * 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
US7344733B2 (en) * 2001-07-28 2008-03-18 Hexal Ag Matrix controlled transdermal therapeutic system for the use of pramipexole and ropinirole
US20040253299A1 (en) * 2001-07-30 2004-12-16 Cornelia Beier Transdermal therapeutic system (reservoir-tts) for using pramipexole and ropinirole
US20050175680A1 (en) * 2002-06-25 2005-08-11 Acrux Dds Pty Ltd. Transdermal delivery rate control using amorphous pharmaceutical compositions
US20090035377A1 (en) * 2003-07-21 2009-02-05 Noven Pharmaceuticals, Inc. Composition and method for controlling drug delivery from silicone adhesive blends
US20060078604A1 (en) * 2004-10-08 2006-04-13 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2561865A4 *

Also Published As

Publication number Publication date
EP2561865A2 (en) 2013-02-27
CN102946873B (zh) 2015-05-13
KR101292768B1 (ko) 2013-08-05
JP5658353B2 (ja) 2015-01-21
JP2013525345A (ja) 2013-06-20
KR20110118525A (ko) 2011-10-31
US20130165875A1 (en) 2013-06-27
WO2011132966A2 (ko) 2011-10-27
CN102946873A (zh) 2013-02-27
EP2561865A4 (en) 2014-05-28

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