MX347372B - Uso de metformina en combinacion con un activador de glucoquinasa y composiciones que comprenden metformina y un activador de glucoquinasa. - Google Patents

Uso de metformina en combinacion con un activador de glucoquinasa y composiciones que comprenden metformina y un activador de glucoquinasa.

Info

Publication number
MX347372B
MX347372B MX2012013617A MX2012013617A MX347372B MX 347372 B MX347372 B MX 347372B MX 2012013617 A MX2012013617 A MX 2012013617A MX 2012013617 A MX2012013617 A MX 2012013617A MX 347372 B MX347372 B MX 347372B
Authority
MX
Mexico
Prior art keywords
metformin
glucokinase activator
activator
combination
compositions
Prior art date
Application number
MX2012013617A
Other languages
English (en)
Other versions
MX2012013617A (es
Inventor
M M Mjalli Adnan
Carmen Valcarce Lopez Maria
Original Assignee
Vtv Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vtv Therapeutics Llc filed Critical Vtv Therapeutics Llc
Publication of MX2012013617A publication Critical patent/MX2012013617A/es
Publication of MX347372B publication Critical patent/MX347372B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención proporciona usos de un activador de glucoquinasa en combinación con metformina. Los usos incluyen el tratamiento de diabetes tipo 2, la disminución de la glucosa en sangre, el mejoramiento de la sensibilidad a la insulina, el mejoramiento de la fosforilación de la glucosa y el mejoramiento de la eficacia terapéutica de metformina. La invención también proporciona composiciones farmacéuticas que comprenden un activador de GK y metformina. La invención también proporciona una sal formada entre metformina y un activador de GK.
MX2012013617A 2010-05-26 2011-05-24 Uso de metformina en combinacion con un activador de glucoquinasa y composiciones que comprenden metformina y un activador de glucoquinasa. MX347372B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34855410P 2010-05-26 2010-05-26
PCT/US2011/037752 WO2011149945A1 (en) 2010-05-26 2011-05-24 Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator

Publications (2)

Publication Number Publication Date
MX2012013617A MX2012013617A (es) 2013-03-20
MX347372B true MX347372B (es) 2017-04-25

Family

ID=45004334

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013617A MX347372B (es) 2010-05-26 2011-05-24 Uso de metformina en combinacion con un activador de glucoquinasa y composiciones que comprenden metformina y un activador de glucoquinasa.

Country Status (30)

Country Link
US (4) US9359313B2 (es)
EP (1) EP2576524B1 (es)
JP (1) JP5902676B2 (es)
KR (2) KR101878252B1 (es)
CN (1) CN102906077B (es)
AU (1) AU2011258460B2 (es)
BR (1) BR112012029844A2 (es)
CA (1) CA2799591C (es)
CO (1) CO6640324A2 (es)
CY (1) CY1119850T1 (es)
DK (1) DK2576524T3 (es)
EA (1) EA032085B1 (es)
ES (1) ES2655396T3 (es)
HR (1) HRP20180113T1 (es)
HU (1) HUE036009T2 (es)
IL (1) IL223137A0 (es)
LT (1) LT2576524T (es)
ME (1) ME03007B (es)
MX (1) MX347372B (es)
NO (1) NO2576524T3 (es)
NZ (1) NZ603614A (es)
PE (1) PE20130275A1 (es)
PL (1) PL2576524T3 (es)
PT (1) PT2576524T (es)
RS (1) RS56761B1 (es)
SG (1) SG185660A1 (es)
SI (1) SI2576524T1 (es)
SM (1) SMT201800140T1 (es)
TW (1) TWI508723B (es)
WO (1) WO2011149945A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603614A (en) * 2010-05-26 2014-10-31 Transtech Pharma Llc Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
CN118453592A (zh) * 2012-05-17 2024-08-09 Vtv治疗有限责任公司 用于治疗糖尿病的葡萄糖激酶活化剂组合物
WO2014137797A2 (en) * 2013-03-04 2014-09-12 Transtech Pharma, Llc Stable glucokinase activator compositions
AU2014226292B2 (en) * 2013-03-04 2018-10-04 Vtv Therapeutics Llc Solid compositions comprising a glucokinase activator and methods of making and using the same
WO2018089427A1 (en) * 2016-11-09 2018-05-17 Novomedix, Llc Nitrite salts of 1, 1-dimethylbiguanide, pharmaceutical compositions, and methods of use
LT3804714T (lt) * 2018-05-31 2025-03-10 Hua Medicine (Shanghai) Ltd. Farmacinis derinys ir kompozicija, ir derinio preparatas, kurio sudėtyje yra gliukokinazės aktyvatorius ir biguanido hipoglikeminis vaistas, taip pat jų gamybos būdas ir panaudojimas
AU2019287437A1 (en) * 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2021167840A1 (en) 2020-02-18 2021-08-26 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CN116194442A (zh) 2020-06-08 2023-05-30 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的盐或共晶体及其用途
CN121202809A (zh) * 2020-06-08 2025-12-26 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的结晶形式及其用途
CN115073330A (zh) * 2021-03-15 2022-09-20 中国医学科学院药物研究所 二甲双胍肉桂酸盐及制备方法和其组合物与用途

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Publication number Priority date Publication date Assignee Title
AT323195B (de) * 1973-03-16 1975-06-25 Hurka Wilhelm Verfahren zur herstellung neuer salze von biguaniden
FR2243684B1 (es) 1973-09-19 1977-01-28 Semb
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
ITRM20030053A1 (it) * 2003-02-10 2004-08-11 Sigma Tau Ind Farmaceuti Associazione di farmaci antidiabetici.
WO2005023766A1 (en) * 2003-09-11 2005-03-17 Biocon Limited Salt of atorvastatin with metformin
PT1723128E (pt) * 2004-01-06 2013-02-27 Novo Nordisk As Heteroaril-ureias e o seu uso como activadores da glicoquinase
WO2006037233A1 (en) * 2004-10-07 2006-04-13 Stem Cell Therapeutics Corp. Stimulation of proliferation of pluripotential stem cells through administration of pregnancy associated compounds
KR20080024211A (ko) * 2005-07-08 2008-03-17 노보 노르디스크 에이/에스 디시클로알킬 우레아 글루코키나제 활성제
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
BRPI0612996A2 (pt) * 2005-07-14 2010-12-14 Novo Nordisk As ativadores de urÉia glucocinase
US8138185B2 (en) 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
EA018988B1 (ru) 2008-05-16 2013-12-30 Такеда Калифорния, Инк. Активаторы глюкокиназы
KR101190957B1 (ko) 2009-08-25 2012-10-15 한올바이오파마주식회사 메트포르민 카페익산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
NZ603614A (en) * 2010-05-26 2014-10-31 Transtech Pharma Llc Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
CN118453592A (zh) 2012-05-17 2024-08-09 Vtv治疗有限责任公司 用于治疗糖尿病的葡萄糖激酶活化剂组合物
WO2014137797A2 (en) 2013-03-04 2014-09-12 Transtech Pharma, Llc Stable glucokinase activator compositions
AU2014226292B2 (en) 2013-03-04 2018-10-04 Vtv Therapeutics Llc Solid compositions comprising a glucokinase activator and methods of making and using the same

Also Published As

Publication number Publication date
CN102906077B (zh) 2015-03-04
HRP20180113T1 (hr) 2018-02-23
KR20180028539A (ko) 2018-03-16
KR101878252B1 (ko) 2018-07-13
WO2011149945A1 (en) 2011-12-01
PE20130275A1 (es) 2013-03-17
IL223137A0 (en) 2013-02-03
CO6640324A2 (es) 2013-03-22
PL2576524T3 (pl) 2018-03-30
EP2576524A1 (en) 2013-04-10
KR20130109015A (ko) 2013-10-07
EP2576524A4 (en) 2014-03-05
TWI508723B (zh) 2015-11-21
SI2576524T1 (en) 2018-01-31
AU2011258460B2 (en) 2015-02-19
HUE036009T2 (hu) 2018-06-28
JP5902676B2 (ja) 2016-04-13
EP2576524B1 (en) 2017-10-25
US20180344706A1 (en) 2018-12-06
BR112012029844A2 (pt) 2015-10-13
US10363244B2 (en) 2019-07-30
US20170354647A1 (en) 2017-12-14
CA2799591A1 (en) 2011-12-01
US20110313007A1 (en) 2011-12-22
NO2576524T3 (es) 2018-03-24
SG185660A1 (en) 2012-12-28
HK1181044A1 (en) 2013-11-01
NZ603614A (en) 2014-10-31
US9855251B2 (en) 2018-01-02
JP2013526608A (ja) 2013-06-24
ES2655396T3 (es) 2018-02-19
PT2576524T (pt) 2017-11-17
US10064846B2 (en) 2018-09-04
SMT201800140T1 (it) 2018-05-02
CN102906077A (zh) 2013-01-30
RS56761B1 (sr) 2018-04-30
ME03007B (me) 2018-10-20
TW201201791A (en) 2012-01-16
EA032085B1 (ru) 2019-04-30
AU2011258460A1 (en) 2013-01-10
LT2576524T (lt) 2017-12-27
EA201201617A1 (ru) 2013-04-30
US20160184277A1 (en) 2016-06-30
KR101860120B1 (ko) 2018-05-23
US9359313B2 (en) 2016-06-07
MX2012013617A (es) 2013-03-20
CY1119850T1 (el) 2018-06-27
CA2799591C (en) 2019-06-11
DK2576524T3 (en) 2018-01-22

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