WO2009072629A1 - 皮膚外用剤 - Google Patents

皮膚外用剤 Download PDF

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Publication number
WO2009072629A1
WO2009072629A1 PCT/JP2008/072201 JP2008072201W WO2009072629A1 WO 2009072629 A1 WO2009072629 A1 WO 2009072629A1 JP 2008072201 W JP2008072201 W JP 2008072201W WO 2009072629 A1 WO2009072629 A1 WO 2009072629A1
Authority
WO
WIPO (PCT)
Prior art keywords
fat
soluble drug
wax
external preparation
skin external
Prior art date
Application number
PCT/JP2008/072201
Other languages
English (en)
French (fr)
Inventor
Eriko Takeoka
Takashi Teshigawara
Kentaro Kusaba
Akira Matsuo
Junko Tamura
Original Assignee
Shiseido Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Company, Ltd. filed Critical Shiseido Company, Ltd.
Priority to EP08856959.5A priority Critical patent/EP2233154A4/en
Priority to US12/745,906 priority patent/US20100316581A1/en
Priority to BRPI0821087-0A priority patent/BRPI0821087A2/pt
Priority to CN2008801196182A priority patent/CN101918031A/zh
Priority to AU2008332297A priority patent/AU2008332297B2/en
Publication of WO2009072629A1 publication Critical patent/WO2009072629A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/652—The particulate/core comprising organic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

課題　油溶性の薬剤（レチノール、酢酸トコフェロール等）の初期浸透速度を制御して徐放することによって、皮膚刺激を低減し、みずみずしい感触を有し、安全性に優れ、かつ、安定性にも優れる皮膚外用剤を提供する。 解決手段　油溶性薬剤含有ワックス微細分散組成物を含む皮膚外用剤であって、前記油溶性薬剤含有ワックス微細分散組成物が、固体～半固体のワックスと、非イオン界面活性剤と、水系分散媒と、油溶性薬剤を含有し、非イオン界面活性剤／ワックスの質量比が１．０以上であり、ワックスが油溶性薬剤を内包して固体～半固体状で水系分散媒中に微細分散してなるものである、上記皮膚外用剤。
PCT/JP2008/072201 2007-12-07 2008-12-05 皮膚外用剤 WO2009072629A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08856959.5A EP2233154A4 (en) 2007-12-07 2008-12-05 EXTERNAL SKIN PREPARATION
US12/745,906 US20100316581A1 (en) 2007-12-07 2008-12-05 Skin External Preparations
BRPI0821087-0A BRPI0821087A2 (pt) 2007-12-07 2008-12-05 Preparação externa para a pele.
CN2008801196182A CN101918031A (zh) 2007-12-07 2008-12-05 皮肤外用剂
AU2008332297A AU2008332297B2 (en) 2007-12-07 2008-12-05 Skin external preparation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007317631 2007-12-07
JP2007-317631 2007-12-07
JP2008309771A JP4341983B2 (ja) 2007-12-07 2008-12-04 皮膚外用剤
JP2008-309771 2008-12-04

Publications (1)

Publication Number Publication Date
WO2009072629A1 true WO2009072629A1 (ja) 2009-06-11

Family

ID=40717807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072201 WO2009072629A1 (ja) 2007-12-07 2008-12-05 皮膚外用剤

Country Status (10)

Country Link
US (1) US20100316581A1 (ja)
EP (1) EP2233154A4 (ja)
JP (1) JP4341983B2 (ja)
KR (1) KR101591672B1 (ja)
CN (1) CN101918031A (ja)
AU (1) AU2008332297B2 (ja)
BR (1) BRPI0821087A2 (ja)
RU (1) RU2010128073A (ja)
TW (1) TWI438007B (ja)
WO (1) WO2009072629A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219463A (ja) * 2010-03-24 2011-11-04 Daiichi Sankyo Healthcare Co Ltd ビタミンｄ類が安定化された化粧用又は医薬用外用組成物
US20120164357A1 (en) * 2009-09-17 2012-06-28 Shiseido Company, Ltd. External Preparation
US20120189675A1 (en) * 2009-03-31 2012-07-26 Shiseido Company, Ltd. Skin External Preparations
JP2013209334A (ja) * 2012-03-30 2013-10-10 Kobayashi Pharmaceutical Co Ltd 表皮肥厚促進剤
JP2014122193A (ja) * 2012-12-21 2014-07-03 L'oreal Sa 油、非イオン界面活性剤及びビタミンｂ３を含む化粧品組成物
JP2019514947A (ja) * 2016-05-12 2019-06-06 ユニリーバー・ナームローゼ・ベンノートシヤープ レチノイン酸前駆体を安定化させるための方法および安定化レチノイン酸前駆体を含む皮膚有益組成物

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499432B (zh) * 2009-09-17 2015-09-11 Shiseido Co Ltd Skin external use
JP5528875B2 (ja) * 2010-03-26 2014-06-25 日本メナード化粧品株式会社 透明液状皮膚外用剤
EP2692331A4 (en) * 2011-03-30 2014-11-26 Fujifilm Corp CAROTENOID-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME
US11065206B2 (en) * 2011-06-29 2021-07-20 Avidas Pharmaceuticals, LLC Topical formulations including lipid microcapsule delivery vehicles and their uses
JP5865622B2 (ja) * 2011-08-01 2016-02-17 昭和電工株式会社 皮膚外用剤およびその製造方法
JP5865623B2 (ja) * 2011-08-01 2016-02-17 昭和電工株式会社 皮膚外用剤およびその製造方法
JP2013126974A (ja) * 2011-11-18 2013-06-27 Fujifilm Corp カロチノイド含有組成物及びその製造方法
CN104203205B (zh) 2012-03-22 2017-06-23 富士胶片株式会社 透明性高的乳化组合物及透明性高的化妆料
CN104379122B (zh) * 2012-09-28 2018-10-26 富士胶片株式会社 化妆品和含有甘草次酸衍生物的乳化组合物
JP6082981B2 (ja) * 2012-12-17 2017-02-22 株式会社トキワ 水中油型乳化固形化粧料
JP6592233B2 (ja) * 2013-12-25 2019-10-16 ロート製薬株式会社 皮膚外用組成物
US20160331764A1 (en) * 2014-01-28 2016-11-17 Resdevco Research And Development Co. Ltd. Composition comprising xylitol and cholecalciferol for topical treatment of skin and mucous membranes
JP6415156B2 (ja) * 2014-07-23 2018-10-31 小林製薬株式会社 外用組成物
US10603266B2 (en) * 2014-10-09 2020-03-31 Mediproduce, Inc. Eyelash cleaning agent
JP6753312B2 (ja) * 2014-12-26 2020-09-09 ニプロ株式会社 医療用皮膚外用剤
JP6498446B2 (ja) * 2015-01-13 2019-04-10 日本メナード化粧品株式会社 透明化粧料
JP6574329B2 (ja) * 2015-01-29 2019-09-11 株式会社日清製粉グループ本社 食用油脂の製造方法
JP6798149B2 (ja) * 2015-06-12 2020-12-09 大正製薬株式会社 タウリン含有組成物
JP6639892B2 (ja) * 2015-12-15 2020-02-05 オリザ油化株式会社 γ−オリザノール可溶化液体組成物
CN105769622A (zh) * 2016-04-22 2016-07-20 广西壮族自治区林业科学研究院 一种干性皮肤护理用精华油及其制备方法
JP6920031B2 (ja) * 2016-06-30 2021-08-18 小林製薬株式会社 慢性角化型湿疹改善剤
JP7182761B2 (ja) * 2017-02-28 2022-12-05 株式会社ピカソ美化学研究所 パール剤およびパール感を有する化粧料
JP6966359B2 (ja) * 2017-03-08 2021-11-17 株式会社コーセー 油性固形化粧料
JP6847728B2 (ja) * 2017-03-24 2021-03-24 株式会社コーセー 皮膚外用剤又は化粧料
GB201712844D0 (en) * 2017-08-10 2017-09-27 Croda Int Plc Emulsifier system, personal care product, method and use
JP2019131524A (ja) * 2018-02-01 2019-08-08 株式会社コーセー 化粧料及び皮膚外用剤
WO2021162074A1 (ja) * 2020-02-14 2021-08-19 株式会社コーセー 水性化粧料
CN114939079B (zh) * 2022-05-19 2024-04-23 上海奥利实业有限公司 一种视黄醇及其衍生物包裹体的制备方法及其应用
WO2024142967A1 (ja) * 2022-12-28 2024-07-04 株式会社 資生堂 高い保湿効果を有する組成物

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JPH032112A (ja) 1989-02-24 1991-01-08 L'oreal Sa ワツクスの微小分散物を含有する毛髪用化粧料組成物
JPH04230616A (ja) 1990-08-23 1992-08-19 L'oreal Sa 毛髪用化粧品および処理方法
JPH10324617A (ja) 1997-03-21 1998-12-08 Shiseido Co Ltd ワックスの微細分散組成物および毛髪化粧料ならびにつや出し剤
JPH11113487A (ja) 1997-02-25 1999-04-27 Nisshin Oil Mills Ltd:The 油性組成物及びその製造方法
JPH11263915A (ja) 1998-03-18 1999-09-28 Shiseido Co Ltd ワックスの微細分散組成物および毛髪化粧料ならびにつや出し剤
JPH11286418A (ja) 1998-03-31 1999-10-19 Shiseido Co Ltd 水中油型毛髪化粧料
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JP2004523519A (ja) * 2001-01-18 2004-08-05 コグニス・ドイッチュランド・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト 真珠箔剤
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Publication number Priority date Publication date Assignee Title
JPH032112A (ja) 1989-02-24 1991-01-08 L'oreal Sa ワツクスの微小分散物を含有する毛髪用化粧料組成物
JPH04230616A (ja) 1990-08-23 1992-08-19 L'oreal Sa 毛髪用化粧品および処理方法
JPH11113487A (ja) 1997-02-25 1999-04-27 Nisshin Oil Mills Ltd:The 油性組成物及びその製造方法
JPH10324617A (ja) 1997-03-21 1998-12-08 Shiseido Co Ltd ワックスの微細分散組成物および毛髪化粧料ならびにつや出し剤
JPH11263915A (ja) 1998-03-18 1999-09-28 Shiseido Co Ltd ワックスの微細分散組成物および毛髪化粧料ならびにつや出し剤
JPH11286418A (ja) 1998-03-31 1999-10-19 Shiseido Co Ltd 水中油型毛髪化粧料
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JP2004083437A (ja) * 2002-08-23 2004-03-18 Shiseido Co Ltd 局所麻酔用固形状組成物
JP2006516029A (ja) * 2003-01-08 2006-06-15 コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ワックス分散液
JP2007531777A (ja) * 2004-04-05 2007-11-08 コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 部分グリセリドとペンタエリスリトールエステルに基づくワックス混合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2233154A4 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120189675A1 (en) * 2009-03-31 2012-07-26 Shiseido Company, Ltd. Skin External Preparations
US9839588B2 (en) * 2009-03-31 2017-12-12 Shiseido Company, Ltd. Skin external preparation comprising an aqueous dispersion of finely dispersed wax, nonionic surfactant, and ionic water-soluble thickener
US20120164357A1 (en) * 2009-09-17 2012-06-28 Shiseido Company, Ltd. External Preparation
JP2011219463A (ja) * 2010-03-24 2011-11-04 Daiichi Sankyo Healthcare Co Ltd ビタミンｄ類が安定化された化粧用又は医薬用外用組成物
JP2013209334A (ja) * 2012-03-30 2013-10-10 Kobayashi Pharmaceutical Co Ltd 表皮肥厚促進剤
JP2014122193A (ja) * 2012-12-21 2014-07-03 L'oreal Sa 油、非イオン界面活性剤及びビタミンｂ３を含む化粧品組成物
JP2019514947A (ja) * 2016-05-12 2019-06-06 ユニリーバー・ナームローゼ・ベンノートシヤープ レチノイン酸前駆体を安定化させるための方法および安定化レチノイン酸前駆体を含む皮膚有益組成物
US11324679B2 (en) 2016-05-12 2022-05-10 Conopco, Inc. Method for stabilizing retinoic acid precursors and a skin benefit composition with stabilized retinoic acid precursors
JP2022105148A (ja) * 2016-05-12 2022-07-12 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ レチノイン酸前駆体を安定化させるための方法および安定化レチノイン酸前駆体を含む皮膚有益組成物
JP7109375B2 (ja) 2016-05-12 2022-07-29 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ レチノイン酸前駆体を安定化させるための方法および安定化レチノイン酸前駆体を含む皮膚有益組成物
JP7305841B2 (ja) 2016-05-12 2023-07-10 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ レチノイン酸前駆体を安定化させるための方法および安定化レチノイン酸前駆体を含む皮膚有益組成物
US11826449B2 (en) 2016-05-12 2023-11-28 Conopco, Inc. Method for stabilizing retinoic acid precursors and a skin benefit composition with stabilized retinoic acid precursors

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AU2008332297A1 (en) 2009-06-11
US20100316581A1 (en) 2010-12-16
BRPI0821087A2 (pt) 2015-06-16
KR20100098677A (ko) 2010-09-08
AU2008332297B2 (en) 2015-01-29
JP4341983B2 (ja) 2009-10-14
EP2233154A4 (en) 2016-01-06
EP2233154A1 (en) 2010-09-29
JP2009155326A (ja) 2009-07-16
TWI438007B (zh) 2014-05-21
RU2010128073A (ru) 2012-01-20
TW200932282A (en) 2009-08-01
KR101591672B1 (ko) 2016-02-04

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