WO2009072626A1 - ヘテロ環化合物による造血幹細胞の増幅方法 - Google Patents

ヘテロ環化合物による造血幹細胞の増幅方法 Download PDF

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WO2009072626A1
WO2009072626A1 PCT/JP2008/072190 JP2008072190W WO2009072626A1 WO 2009072626 A1 WO2009072626 A1 WO 2009072626A1 JP 2008072190 W JP2008072190 W JP 2008072190W WO 2009072626 A1 WO2009072626 A1 WO 2009072626A1
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compound
positive cell
hematopoietic stem
stem cell
cell
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PCT/JP2008/072190
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French (fr)
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Takanori Nakamura
Atsushi Miyamura
Taito Nishino
Norihisa Ishiwata
Katsuaki Miyaji
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Nissan Chemical Industries, Ltd.
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Priority to US12/746,507 priority Critical patent/US9115341B2/en
Priority to JP2009544754A priority patent/JP5573161B2/ja
Priority to EP08856980A priority patent/EP2233561A4/en
Publication of WO2009072626A1 publication Critical patent/WO2009072626A1/ja

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    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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Abstract

　本発明は、生物学的に安全かつ廉価にて製造可能な低分子化合物を利用し、ＣＤ３４陽性細胞を生体外で従来よりも効率的かつ短期間に増幅することを課題とする。本発明のさらなる課題は、造血幹細胞及び／又は造血前駆細胞の機能不全に伴う各種の造血系疾患に対する治療方法として有用である、ＣＤ３４陽性細胞の増幅剤を提供することにある。 　式（１）（式中の、Ａ、Ｂ、Ｌ１、Ｌ２、Ｌ３、Ｌ４、Ｒ１、Ｒ２、Ｒ３、Ｘ及びＹは、本文中において定義される。）で表される化合物、該化合物の互変異性体若しくはその医薬的に許容され得る塩又はそれらの溶媒和物の存在下、ＣＤ３４陽性細胞を生体外で培養することを特徴とするＣＤ３４陽性細胞の増幅方法。
PCT/JP2008/072190 2007-12-05 2008-12-05 ヘテロ環化合物による造血幹細胞の増幅方法 WO2009072626A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/746,507 US9115341B2 (en) 2007-12-05 2008-12-05 Method for expanding hematopoietic stem cells using heterocyclic compound
JP2009544754A JP5573161B2 (ja) 2007-12-05 2008-12-05 ヘテロ環化合物による造血幹細胞の増幅方法
EP08856980A EP2233561A4 (en) 2007-12-05 2008-12-05 METHOD FOR AMPLIFYING HEMATOPOIETIC STRAIN CELL USING HETEROCYCLIC COMPOUND

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-315168 2007-12-05
JP2007315168 2007-12-05

Publications (1)

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WO2009072626A1 true WO2009072626A1 (ja) 2009-06-11

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PCT/JP2008/072190 WO2009072626A1 (ja) 2007-12-05 2008-12-05 ヘテロ環化合物による造血幹細胞の増幅方法

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Country Link
US (1) US9115341B2 (ja)
EP (1) EP2233561A4 (ja)
JP (1) JP5573161B2 (ja)
KR (1) KR101585276B1 (ja)
WO (1) WO2009072626A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010140685A1 (ja) * 2009-06-04 2010-12-09 日産化学工業株式会社 ヘテロ環化合物及び造血幹細胞の増幅剤
JPWO2009072625A1 (ja) * 2007-12-05 2011-04-28 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
JPWO2009072624A1 (ja) * 2007-12-05 2011-04-28 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
WO2012060388A1 (ja) * 2010-11-02 2012-05-10 日産化学工業株式会社 アミノ安息香酸誘導体の有機アミン塩及びその製造方法
JP2012111750A (ja) * 2010-11-02 2012-06-14 Nissan Chem Ind Ltd アミノ安息香酸誘導体の溶媒和物及びその製造方法
WO2013051625A1 (ja) 2011-10-03 2013-04-11 日産化学工業株式会社 多能性幹細胞からの巨核球及び／又は血小板の製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115715203A (zh) 2020-05-06 2023-02-24 塞勒克提斯公司 对细胞进行基因修饰以递送治疗性蛋白质的方法
US20230212613A1 (en) 2020-05-06 2023-07-06 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes

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Cited By (15)

* Cited by examiner, † Cited by third party
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JP5573159B2 (ja) * 2007-12-05 2014-08-20 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
JPWO2009072625A1 (ja) * 2007-12-05 2011-04-28 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
JPWO2009072624A1 (ja) * 2007-12-05 2011-04-28 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
JP5573160B2 (ja) * 2007-12-05 2014-08-20 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
EP2439204A1 (en) * 2009-06-04 2012-04-11 Nissan Chemical Industries, Ltd. Heterocyclic compound and hematopoietic stem cell amplifier
EP2439204A4 (en) * 2009-06-04 2012-06-20 Nissan Chemical Ind Ltd HETEROCYCLIC CONNECTION AND HEMATOPOIETIC STEM CELL AMPLIFIER
WO2010140685A1 (ja) * 2009-06-04 2010-12-09 日産化学工業株式会社 ヘテロ環化合物及び造血幹細胞の増幅剤
US9328085B2 (en) 2009-06-04 2016-05-03 Nissan Chemical Industries, Ltd. Heterocyclic compounds and expansion agents for hematopoietic stem cells
JP2012111750A (ja) * 2010-11-02 2012-06-14 Nissan Chem Ind Ltd アミノ安息香酸誘導体の溶媒和物及びその製造方法
WO2012060388A1 (ja) * 2010-11-02 2012-05-10 日産化学工業株式会社 アミノ安息香酸誘導体の有機アミン塩及びその製造方法
US8946286B2 (en) 2010-11-02 2015-02-03 Nissan Chemical Industries, Ltd. Organic amine salts of aminobenzoic acid derivatives and method for producing same
RU2569885C2 (ru) * 2010-11-02 2015-12-10 Ниссан Кемикал Индастриз, Лтд. Органические аминные соли производных аминобензойной кислоты и способ их получения
JP5892069B2 (ja) * 2010-11-02 2016-03-23 日産化学工業株式会社 アミノ安息香酸誘導体の有機アミン塩及びその製造方法
WO2013051625A1 (ja) 2011-10-03 2013-04-11 日産化学工業株式会社 多能性幹細胞からの巨核球及び／又は血小板の製造方法
KR20140082673A (ko) 2011-10-03 2014-07-02 닛산 가가쿠 고교 가부시키 가이샤 다능성 간세포로부터의 거핵구 및/또는 혈소판의 제조 방법

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Publication number Publication date
KR20100098522A (ko) 2010-09-07
JPWO2009072626A1 (ja) 2011-04-28
KR101585276B1 (ko) 2016-01-13
JP5573161B2 (ja) 2014-08-20
US9115341B2 (en) 2015-08-25
EP2233561A4 (en) 2013-01-16
EP2233561A1 (en) 2010-09-29
US20100310537A1 (en) 2010-12-09

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