WO2008153182A1 - モルホリン誘導体 - Google Patents

モルホリン誘導体 Download PDF

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Publication number
WO2008153182A1
WO2008153182A1 PCT/JP2008/061004 JP2008061004W WO2008153182A1 WO 2008153182 A1 WO2008153182 A1 WO 2008153182A1 JP 2008061004 W JP2008061004 W JP 2008061004W WO 2008153182 A1 WO2008153182 A1 WO 2008153182A1
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WIPO (PCT)
Prior art keywords
group
optionally substituted
alkyl group
alkyl
formula
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PCT/JP2008/061004
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English (en)
French (fr)
Inventor
Hidenori Akatsuka
Hiroshi Sugama
Nobumasa Awai
Takayuki Kawaguchi
Yoichi Takahashi
Toru Iijima
Jingkang Shen
Guangxin Xia
Jianshu Xie
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Shanghai Pharmaceutical (Group) Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Mitsubishi Tanabe Pharma Corporation, Shanghai Pharmaceutical (Group) Co., Ltd. filed Critical Mitsubishi Tanabe Pharma Corporation
Priority to EP08777242.2A priority Critical patent/EP2168952B1/en
Priority to BRPI0813354-9A2A priority patent/BRPI0813354A2/pt
Priority to ES08777242.2T priority patent/ES2618460T3/es
Priority to CN2008800202453A priority patent/CN101679324B/zh
Priority to AU2008262894A priority patent/AU2008262894A1/en
Priority to MX2009013822A priority patent/MX2009013822A/es
Priority to US12/664,637 priority patent/US8975252B2/en
Priority to CA2690348A priority patent/CA2690348A1/en
Priority to JP2009519335A priority patent/JP5368304B2/ja
Publication of WO2008153182A1 publication Critical patent/WO2008153182A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

本発明は、レニン阻害剤として有用な式［Ｉ］： （式中、Ｒ１は、Ａ）置換されていてもよいアルコキシ基等から選ばれる基で置換されたアルキル基、Ｂ）置換されていてもよいアリール基、Ｃ）置換されていてもよい複素環式基、Ｄ）シクロアルキル基又はＥ）アルキル基、 Ｒ２は、Ａ）置換されていてもよいアルコキシ基等から選ばれる基で置換されたアルキル基、Ｂ）置換されていてもよいアリール基、Ｃ）置換されていてもよい複素環式基、Ｄ）置換されていてもよいアルキルカルボニル基、Ｅ）置換されていてもよいアリールカルボニル基、Ｆ）置換されていてもよい複素環式基置換カルボニル基又はＧ）シクロアルキルカルボニル基、 Ｔは、メチレン基又はカルボニル基、 Ｒ３、Ｒ４、Ｒ５及びＲ６は、同一又は異なって、水素原子、置換されていてもよいカルバモイル基又は置換されていてもよいアルキル基を示す。） により表されるモルホリン誘導体またはその薬理的に許容しうる塩を提供する。
PCT/JP2008/061004 2007-06-15 2008-06-16 モルホリン誘導体 WO2008153182A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP08777242.2A EP2168952B1 (en) 2007-06-15 2008-06-16 Morpholine derivatives as renin inhibitors
BRPI0813354-9A2A BRPI0813354A2 (pt) 2007-06-15 2008-06-16 Derivado de morfolina
ES08777242.2T ES2618460T3 (es) 2007-06-15 2008-06-16 Derivados de morfolina como inhibidores de renina
CN2008800202453A CN101679324B (zh) 2007-06-15 2008-06-16 吗啉衍生物
AU2008262894A AU2008262894A1 (en) 2007-06-15 2008-06-16 Morpholine derivative
MX2009013822A MX2009013822A (es) 2007-06-15 2008-06-16 Derivado de morfolina.
US12/664,637 US8975252B2 (en) 2007-06-15 2008-06-16 Morpholine derivative
CA2690348A CA2690348A1 (en) 2007-06-15 2008-06-16 Morpholine derivative
JP2009519335A JP5368304B2 (ja) 2007-06-15 2008-06-16 モルホリン誘導体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007158892 2007-06-15
JP2007-158892 2007-06-15
JP2007231532 2007-09-06
JP2007-231532 2007-09-06

Publications (1)

Publication Number Publication Date
WO2008153182A1 true WO2008153182A1 (ja) 2008-12-18

Family

ID=40129782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061004 WO2008153182A1 (ja) 2007-06-15 2008-06-16 モルホリン誘導体

Country Status (13)

Country Link
US (1) US8975252B2 (ja)
EP (1) EP2168952B1 (ja)
JP (1) JP5368304B2 (ja)
KR (1) KR20100046145A (ja)
CN (1) CN101679324B (ja)
AU (1) AU2008262894A1 (ja)
BR (1) BRPI0813354A2 (ja)
CA (1) CA2690348A1 (ja)
ES (1) ES2618460T3 (ja)
MX (1) MX2009013822A (ja)
RU (1) RU2010101067A (ja)
TW (1) TWI452044B (ja)
WO (1) WO2008153182A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012124775A1 (ja) 2011-03-16 2012-09-20 田辺三菱製薬株式会社 含窒素飽和複素環化合物
US8389511B2 (en) 2007-12-19 2013-03-05 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic heterocyclic derivative
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
WO2014042263A1 (ja) 2012-09-14 2014-03-20 田辺三菱製薬株式会社 新規レニン阻害薬
JP2014074024A (ja) * 2012-09-14 2014-04-24 Mitsubishi Tanabe Pharma Corp 医薬組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008080056A2 (en) * 2006-12-21 2008-07-03 Sloan-Kettering Institute For Cancer Research Pyridazinones and furan-containing compounds
CN104250233B (zh) * 2014-08-29 2016-03-16 湖南华腾制药有限公司 一种4-叔丁氧羰基-2-环丙基吗啉的制备方法
CN109705052B (zh) * 2019-01-25 2020-12-08 苏州大学 一种制备1,4-二氢噁嗪的方法
JP7163208B2 (ja) 2019-02-01 2022-10-31 株式会社タチエス 車両用シート

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49124079A (ja) * 1972-08-11 1974-11-27
JPS5390275A (en) * 1977-01-13 1978-08-08 Yoshitomi Pharmaceut Ind Ltd Mopholine derivs.
JPS63301821A (ja) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd 抗不整脈剤
JPH02115182A (ja) * 1988-10-21 1990-04-27 Yoshitomi Pharmaceut Ind Ltd 光学活性ピリドンカルボン酸化合物
JPH03188030A (ja) * 1989-12-18 1991-08-16 Yoshitomi Pharmaceut Ind Ltd 脱ベンジル化方法
JP2003500392A (ja) * 1999-05-25 2003-01-07 セプラコール， インク． 複素環式鎮痛性化合物およびその使用方法
WO2003097618A1 (en) * 2002-05-22 2003-11-27 Glaxo Group Limited Morpholinylmethylureas ccr-3 receptor antagonists
WO2005042516A2 (en) * 2003-10-22 2005-05-12 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
WO2005089731A2 (en) * 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
JP2005336168A (ja) * 2004-04-30 2005-12-08 Otsuka Pharmaceut Co Ltd ４−アミノ−５−シアノピリミジン誘導体
WO2006005741A2 (en) * 2004-07-09 2006-01-19 Speedel Experimenta Ag Piperdine derivatives as renin inhibitors
JP2006517563A (ja) * 2003-02-14 2006-07-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換ｎ−アリール複素環化合物、その製造方法およびその医薬としての使用
JP2006522796A (ja) * 2003-04-10 2006-10-05 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ピペラジン誘導体レニン阻害剤
JP2007055940A (ja) * 2005-08-24 2007-03-08 Astellas Pharma Inc ピラゾロピリミジン誘導体
JP2007145828A (ja) * 2005-10-28 2007-06-14 Otsuka Pharmaceut Co Ltd 医薬組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358949A (en) 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
TWI346109B (en) 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
US7799805B2 (en) * 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
WO2007034406A1 (en) * 2005-09-22 2007-03-29 Actelion Pharmaceuticals Ltd Pyrrolidine-3-carboxylic acid amide derivatives and their use as inhibitors of renin
JP2009518409A (ja) * 2005-12-06 2009-05-07 メルク エンド カムパニー インコーポレーテッド モルホリンカルボキサミドプロキネチシン受容体アンタゴニスト

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49124079A (ja) * 1972-08-11 1974-11-27
JPS5390275A (en) * 1977-01-13 1978-08-08 Yoshitomi Pharmaceut Ind Ltd Mopholine derivs.
JPS63301821A (ja) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd 抗不整脈剤
JPH02115182A (ja) * 1988-10-21 1990-04-27 Yoshitomi Pharmaceut Ind Ltd 光学活性ピリドンカルボン酸化合物
JPH03188030A (ja) * 1989-12-18 1991-08-16 Yoshitomi Pharmaceut Ind Ltd 脱ベンジル化方法
JP2003500392A (ja) * 1999-05-25 2003-01-07 セプラコール， インク． 複素環式鎮痛性化合物およびその使用方法
WO2003097618A1 (en) * 2002-05-22 2003-11-27 Glaxo Group Limited Morpholinylmethylureas ccr-3 receptor antagonists
JP2006517563A (ja) * 2003-02-14 2006-07-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換ｎ−アリール複素環化合物、その製造方法およびその医薬としての使用
JP2006522796A (ja) * 2003-04-10 2006-10-05 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ピペラジン誘導体レニン阻害剤
WO2005042516A2 (en) * 2003-10-22 2005-05-12 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
WO2005089731A2 (en) * 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
JP2005336168A (ja) * 2004-04-30 2005-12-08 Otsuka Pharmaceut Co Ltd ４−アミノ−５−シアノピリミジン誘導体
WO2006005741A2 (en) * 2004-07-09 2006-01-19 Speedel Experimenta Ag Piperdine derivatives as renin inhibitors
JP2007055940A (ja) * 2005-08-24 2007-03-08 Astellas Pharma Inc ピラゾロピリミジン誘導体
JP2007145828A (ja) * 2005-10-28 2007-06-14 Otsuka Pharmaceut Co Ltd 医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATO S. ET AL.: "Novel Benzamides as Selective and Potent Gastric Prokinetic Agents. 1. Synthesis and Structure-Activity Relationships of N-[(2-Morpholinyl)alkyl]benzamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, 1990, pages 1406 - 1413, XP001037844 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389511B2 (en) 2007-12-19 2013-03-05 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic heterocyclic derivative
US9045436B2 (en) 2008-06-19 2015-06-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US9221836B2 (en) 2008-06-19 2015-12-29 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8664380B2 (en) 2008-06-19 2014-03-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
JP5760078B2 (ja) * 2011-03-16 2015-08-05 田辺三菱製薬株式会社 含窒素飽和複素環化合物
WO2012124775A1 (ja) 2011-03-16 2012-09-20 田辺三菱製薬株式会社 含窒素飽和複素環化合物
US9278944B2 (en) 2011-03-16 2016-03-08 Mitsubishi Tanabe Pharma Corporation Nitrogen-containing saturated heterocyclic compound
US10155731B2 (en) 2011-03-16 2018-12-18 Mitsubishi Tanabe Pharma Corporation Nitrogen-containing saturated heterocyclic compound
JP2014074024A (ja) * 2012-09-14 2014-04-24 Mitsubishi Tanabe Pharma Corp 医薬組成物
WO2014042263A1 (ja) 2012-09-14 2014-03-20 田辺三菱製薬株式会社 新規レニン阻害薬
JPWO2014042263A1 (ja) * 2012-09-14 2016-08-18 田辺三菱製薬株式会社 新規レニン阻害薬
US9556159B2 (en) 2012-09-14 2017-01-31 Mitsubishi Tanabe Pharma Corporation Renin inhibitor

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KR20100046145A (ko) 2010-05-06
AU2008262894A1 (en) 2008-12-18
CN101679324A (zh) 2010-03-24
JPWO2008153182A1 (ja) 2010-08-26
US20100240644A1 (en) 2010-09-23
CA2690348A1 (en) 2008-12-18
CN101679324B (zh) 2012-10-03
JP5368304B2 (ja) 2013-12-18
US8975252B2 (en) 2015-03-10
TWI452044B (zh) 2014-09-11
EP2168952B1 (en) 2017-02-15
EP2168952A1 (en) 2010-03-31
BRPI0813354A2 (pt) 2014-12-30
TW200906822A (en) 2009-02-16
EP2168952A4 (en) 2012-03-21

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