WO2008145839A8 - Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique - Google Patents

Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique Download PDF

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Publication number
WO2008145839A8
WO2008145839A8 PCT/FR2008/000532 FR2008000532W WO2008145839A8 WO 2008145839 A8 WO2008145839 A8 WO 2008145839A8 FR 2008000532 W FR2008000532 W FR 2008000532W WO 2008145839 A8 WO2008145839 A8 WO 2008145839A8
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WIPO (PCT)
Prior art keywords
group
carboxamide derivatives
preparation
therapeutic use
triazolopyrimidine
Prior art date
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PCT/FR2008/000532
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English (en)
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WO2008145839A1 (fr
Inventor
Luc Even
Christian Hoornaert
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Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to BRPI0810440-9A2A priority Critical patent/BRPI0810440A2/pt
Priority to EP08787961A priority patent/EP2146990A1/fr
Priority to CA002683929A priority patent/CA2683929A1/fr
Priority to JP2010503547A priority patent/JP2010524904A/ja
Priority to MX2009011212A priority patent/MX2009011212A/es
Priority to AU2008257320A priority patent/AU2008257320A1/en
Publication of WO2008145839A1 publication Critical patent/WO2008145839A1/fr
Priority to US12/573,959 priority patent/US8080547B2/en
Priority to IL201450A priority patent/IL201450A0/en
Publication of WO2008145839A8 publication Critical patent/WO2008145839A8/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

L'invention concerne les dérivés de triazolopyridine-carboxamides et triazolo- pyrimidine-carboxamides, de formule générale (I) dans laquelle : A et X représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupement CH; R1 représente un groupe NR3R4, dans lequel R3 et R4 forment avec l'atome d'azote qui les porte un groupe hétérocyclique de 3 à 7 chaînons pouvant incorporer un atome d'oxygène ou de soufre, un groupe NR ou NR'-CO, ledit cycle étant éventuellement substitué par un ou plusieurs groupes choisis parmi un atome d'halogène ou un groupe (C1-C6)alkyle, (C1-C6)alcoxy, halo(C1-C6)alkyle, halo(C1- C6)alcoxy, R2 représente un groupement aryle, éventuellement substitué par un ou plusieurs groupes choisis parmi un atome d'halogène, un groupe méthyle, trifluorométhyle, méthoxy, trifluorométhoxy. Procédé de préparation et application en thérapeutique.
PCT/FR2008/000532 2007-04-18 2008-04-16 Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique WO2008145839A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0810440-9A2A BRPI0810440A2 (pt) 2007-04-18 2008-04-16 Derivados de triazolopiridina-carboxamidas e triazolopirimidina-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
EP08787961A EP2146990A1 (fr) 2007-04-18 2008-04-16 Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique
CA002683929A CA2683929A1 (fr) 2007-04-18 2008-04-16 Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique
JP2010503547A JP2010524904A (ja) 2007-04-18 2008-04-16 トリアゾロピリジンカルボキサミド誘導体およびトリアゾロピリミジンカルボキサミド誘導体、これらの調製、ならびにこれらの治療的使用
MX2009011212A MX2009011212A (es) 2007-04-18 2008-04-16 Derivados de triazolopiridina carboxamida y triazolopirimidina carboxamida, su preparacion y su aplicacion terapeutica.
AU2008257320A AU2008257320A1 (en) 2007-04-18 2008-04-16 Triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives, preparation thereof and therapeutic use thereof
US12/573,959 US8080547B2 (en) 2007-04-18 2009-10-06 Triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives, preparation thereof and therapeutic use thereof
IL201450A IL201450A0 (en) 2007-04-18 2009-10-11 Triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives, preparation thereof and therapeutic use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0702809A FR2915199B1 (fr) 2007-04-18 2007-04-18 Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
FR0702809 2007-04-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/573,959 Continuation US8080547B2 (en) 2007-04-18 2009-10-06 Triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives, preparation thereof and therapeutic use thereof

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Publication Number Publication Date
WO2008145839A1 WO2008145839A1 (fr) 2008-12-04
WO2008145839A8 true WO2008145839A8 (fr) 2009-11-19

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AU2009330821B2 (en) * 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
BRPI1014874A2 (pt) * 2009-04-22 2016-04-12 Janssen Pharmaceutica Nv piperazinil azetidinil amidas heteroaromáticas e aromáticas como inibidores de monoacilglicerol lipase
TW201105655A (en) * 2009-04-22 2011-02-16 Janssen Pharmaceutica Nv Azetidinyl diamides as monoacylglycerol lipase inhibitors
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US8435977B2 (en) 2009-04-22 2013-05-07 Janssen Pharmaceutica, Nv Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors
CA2773590C (fr) * 2009-09-09 2017-09-05 Keiji Adachi Derives de 8-oxodihydropurine
WO2011085216A2 (fr) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Utilisation d'inhibiteurs de faah pour traiter la maladie de parkinson et le syndrome des jambes sans repos
EP2536720A1 (fr) * 2010-02-18 2012-12-26 Centro Nacional de Investigaciones Oncológicas (CNIO) Composés bicycliques destinés à être utilisés en tant qu'inhibiteurs de kinases
WO2011123719A2 (fr) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Utilisation d'inhibiteurs de faah pour le traitement des douleurs abdominales, viscérales et pelviennes
EA201690998A1 (ru) * 2010-05-17 2017-01-30 Инкозен Терапьютикс Пвт. Лтд. НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ
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JP2013537920A (ja) 2010-09-27 2013-10-07 ヤンセン ファーマシューティカ エヌ．ベー． モノアシルグリセロールリパーゼ阻害剤としてのオキソピペラジン−アゼチジンアミド及びオキソジアゼピン−アゼチジンアミド
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US20100041651A1 (en) 2010-02-18
AR066107A1 (es) 2009-07-22
JP2010524904A (ja) 2010-07-22
UY31032A1 (es) 2008-11-28
CA2683929A1 (fr) 2008-12-04
TW200901993A (en) 2009-01-16
CL2008001104A1 (es) 2009-01-16
BRPI0810440A2 (pt) 2014-10-14
US8080547B2 (en) 2011-12-20
FR2915199B1 (fr) 2010-01-22
MX2009011212A (es) 2009-11-02
WO2008145839A1 (fr) 2008-12-04
EP2146990A1 (fr) 2010-01-27
RU2009142431A (ru) 2011-05-27
AU2008257320A1 (en) 2008-12-04
CN101668758A (zh) 2010-03-10
FR2915199A1 (fr) 2008-10-24
KR20090130057A (ko) 2009-12-17

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