WO2009074749A3 - Dérives de nicotinamide. leur préparation et leur application en thérapeutique - Google Patents
Dérives de nicotinamide. leur préparation et leur application en thérapeutique Download PDFInfo
- Publication number
- WO2009074749A3 WO2009074749A3 PCT/FR2008/001338 FR2008001338W WO2009074749A3 WO 2009074749 A3 WO2009074749 A3 WO 2009074749A3 FR 2008001338 W FR2008001338 W FR 2008001338W WO 2009074749 A3 WO2009074749 A3 WO 2009074749A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- preparation
- hydrogen atom
- therapeutic use
- nicotinamide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2700559A CA2700559A1 (fr) | 2007-09-28 | 2008-09-26 | Derives de nicotinamide, leur preparation et leur application en therapeutique |
JP2010526335A JP2010540504A (ja) | 2007-09-28 | 2008-09-26 | ニコチンアミド誘導体、これらの調製およびこれらの治療目的使用 |
AU2008334457A AU2008334457A1 (en) | 2007-09-28 | 2008-09-26 | Nicotinamide derivatives, preparation thereof and therapeutic use thereof |
MX2010003445A MX2010003445A (es) | 2007-09-28 | 2008-09-26 | Derivados de nicotinamida, su preparacion y su uso terapeutico. |
BRPI0817973-5A BRPI0817973A2 (pt) | 2007-09-28 | 2008-09-26 | derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica |
CN200880109332A CN101808996A (zh) | 2007-09-28 | 2008-09-26 | 烟酰胺衍生物、它们的制备和它们的在治疗学中的应用 |
EP08859496A EP2205566A2 (fr) | 2007-09-28 | 2008-09-26 | Dérives de nicotinamide. leur préparation et leur application en thérapeutique |
IL204663A IL204663A0 (en) | 2007-09-28 | 2010-03-22 | Nicotinamide derivatives, preparastion thereof and therapeutic use thereof |
US12/732,749 US20100222319A1 (en) | 2007-09-28 | 2010-03-26 | Nicotinamide derivatives, preparation thereof and therapeutic use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0706799A FR2921657A1 (fr) | 2007-09-28 | 2007-09-28 | Derives de nicotinamide, leur preparation et leur application en therapeutique |
FR0706799 | 2007-09-28 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/732,749 Continuation US20100222319A1 (en) | 2007-09-28 | 2010-03-26 | Nicotinamide derivatives, preparation thereof and therapeutic use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009074749A2 WO2009074749A2 (fr) | 2009-06-18 |
WO2009074749A3 true WO2009074749A3 (fr) | 2009-08-20 |
Family
ID=39356668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2008/001338 WO2009074749A2 (fr) | 2007-09-28 | 2008-09-26 | Dérives de nicotinamide. leur préparation et leur application en thérapeutique |
Country Status (19)
Country | Link |
---|---|
US (1) | US20100222319A1 (fr) |
EP (1) | EP2205566A2 (fr) |
JP (1) | JP2010540504A (fr) |
KR (1) | KR20100065165A (fr) |
CN (1) | CN101808996A (fr) |
AR (1) | AR066171A1 (fr) |
AU (1) | AU2008334457A1 (fr) |
BR (1) | BRPI0817973A2 (fr) |
CA (1) | CA2700559A1 (fr) |
CL (1) | CL2008002893A1 (fr) |
FR (1) | FR2921657A1 (fr) |
IL (1) | IL204663A0 (fr) |
MX (1) | MX2010003445A (fr) |
PA (1) | PA8797301A1 (fr) |
PE (1) | PE20091033A1 (fr) |
RU (1) | RU2010116765A (fr) |
TW (1) | TW200918056A (fr) |
UY (1) | UY31367A1 (fr) |
WO (1) | WO2009074749A2 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101331768B1 (ko) | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 |
WO2008141119A2 (fr) | 2007-05-09 | 2008-11-20 | Vertex Pharmaceuticals Incorporated | Modulateurs de cftr |
ES2625957T3 (es) * | 2007-12-07 | 2017-07-21 | Vertex Pharmaceuticals Incorporated | Procedimiento para producir ácidos cicloalquilcarboxiamido-piridinabenzoicos |
SI2225230T1 (sl) | 2007-12-07 | 2017-03-31 | Vertex Pharmaceuticals Incorporated | Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline |
AU2009219363B2 (en) | 2008-02-28 | 2013-10-10 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as CFTR modulators |
FR2943670B1 (fr) * | 2009-03-24 | 2011-05-06 | Sanofi Aventis | Derives anticancereux,leur preparation et leur application en therapeutique |
FR2943675A1 (fr) * | 2009-03-24 | 2010-10-01 | Sanofi Aventis | Composes anticancereux, leur preparation et leur application en therapeutique |
FR2943669B1 (fr) * | 2009-03-24 | 2011-05-06 | Sanofi Aventis | Derives de nicotinamide,leur preparation et leur application en therapeutique |
WO2010144647A1 (fr) * | 2009-06-12 | 2010-12-16 | Bristol-Myers Squibb Company | Composés de nicotinamide utiles en tant que modulateurs de kinases |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
AU2011223790A1 (en) * | 2010-03-01 | 2012-08-30 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
NZ708598A (en) | 2010-04-07 | 2017-05-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d](1,3)dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
US8827372B2 (en) | 2010-07-07 | 2014-09-09 | Frontis Corp. | Blowing system |
FR2965263A1 (fr) * | 2010-09-24 | 2012-03-30 | Sanofi Aventis | Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique |
US9169246B2 (en) | 2011-09-26 | 2015-10-27 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
ES2527188T3 (es) * | 2011-09-26 | 2015-01-21 | Sanofi | Derivados de pirazolquinolinona, su preparación y su uso terapéutico |
CN103012397B (zh) * | 2011-09-26 | 2017-03-01 | 赛诺菲 | 吡唑并喹啉酮衍生物、其制备方法及其治疗用途 |
KR102280372B1 (ko) | 2013-11-12 | 2021-07-22 | 버텍스 파마슈티칼스 인코포레이티드 | Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법 |
CN103804270B (zh) * | 2014-01-23 | 2016-06-22 | 中国药科大学 | 5-(4-甲脒基苄氧基)色氨酸衍生物、其制法及应用 |
AU2015350049B2 (en) | 2014-11-18 | 2021-08-19 | Vertex Pharmaceuticals Incorporated | Process of conducting high throughput testing high performance liquid chromatography |
WO2017219935A1 (fr) | 2016-06-22 | 2017-12-28 | 复旦大学 | Dérivé de biaryle urée ou son sel, sa fabrication et son application |
CN107522641B (zh) * | 2016-06-22 | 2020-05-05 | 复旦大学 | 联芳基脲类衍生物或其盐及其制备方法和用途 |
JP2021523168A (ja) * | 2018-05-04 | 2021-09-02 | リメディー プラン, インコーポレーテッドRemedy Plan, Inc. | がん幹細胞を標的化するがん治療 |
CN110396065A (zh) * | 2019-06-25 | 2019-11-01 | 南京普锐达医药科技有限公司 | 一种2,4-二氯-5-嘧啶甲酰氯的合成方法 |
KR20220110744A (ko) * | 2019-11-06 | 2022-08-09 | 레미디 플랜, 인크. | 암 줄기 세포를 표적화하는 암 치료 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035864A1 (fr) * | 1998-12-16 | 2000-06-22 | Bayer Aktiengesellschaft | Nouveaux composes de biphenyle et d'analogues de biphenyle utilises en tant qu'antagonistes d'integrines |
WO2002048099A1 (fr) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Derives d'amides d'acides carboxyliques et leur utilisation dans le traitement de troubles thrombo-emboliques et de tumeurs |
WO2005051366A2 (fr) * | 2003-11-28 | 2005-06-09 | Novartis Ag | Derives de diaryluree utilises en traitement de maladies dependant de proteines kinases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4301110A1 (de) * | 1993-01-18 | 1994-07-21 | Bayer Ag | Verfahren zur Herstellung von 2-Amino-5-aminomethyl-pyridin |
US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
US20060216288A1 (en) * | 2005-03-22 | 2006-09-28 | Amgen Inc | Combinations for the treatment of cancer |
-
2007
- 2007-09-28 FR FR0706799A patent/FR2921657A1/fr not_active Withdrawn
-
2008
- 2008-09-24 TW TW097136703A patent/TW200918056A/zh unknown
- 2008-09-26 KR KR1020107006595A patent/KR20100065165A/ko not_active Application Discontinuation
- 2008-09-26 UY UY31367A patent/UY31367A1/es not_active Application Discontinuation
- 2008-09-26 AU AU2008334457A patent/AU2008334457A1/en not_active Abandoned
- 2008-09-26 CN CN200880109332A patent/CN101808996A/zh active Pending
- 2008-09-26 WO PCT/FR2008/001338 patent/WO2009074749A2/fr active Application Filing
- 2008-09-26 MX MX2010003445A patent/MX2010003445A/es not_active Application Discontinuation
- 2008-09-26 RU RU2010116765/04A patent/RU2010116765A/ru not_active Application Discontinuation
- 2008-09-26 PA PA20088797301A patent/PA8797301A1/es unknown
- 2008-09-26 AR ARP080104193A patent/AR066171A1/es unknown
- 2008-09-26 PE PE2008001687A patent/PE20091033A1/es not_active Application Discontinuation
- 2008-09-26 CL CL2008002893A patent/CL2008002893A1/es unknown
- 2008-09-26 EP EP08859496A patent/EP2205566A2/fr not_active Withdrawn
- 2008-09-26 JP JP2010526335A patent/JP2010540504A/ja not_active Withdrawn
- 2008-09-26 CA CA2700559A patent/CA2700559A1/fr not_active Abandoned
- 2008-09-26 BR BRPI0817973-5A patent/BRPI0817973A2/pt not_active IP Right Cessation
-
2010
- 2010-03-22 IL IL204663A patent/IL204663A0/en unknown
- 2010-03-26 US US12/732,749 patent/US20100222319A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035864A1 (fr) * | 1998-12-16 | 2000-06-22 | Bayer Aktiengesellschaft | Nouveaux composes de biphenyle et d'analogues de biphenyle utilises en tant qu'antagonistes d'integrines |
WO2002048099A1 (fr) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Derives d'amides d'acides carboxyliques et leur utilisation dans le traitement de troubles thrombo-emboliques et de tumeurs |
WO2005051366A2 (fr) * | 2003-11-28 | 2005-06-09 | Novartis Ag | Derives de diaryluree utilises en traitement de maladies dependant de proteines kinases |
Also Published As
Publication number | Publication date |
---|---|
CA2700559A1 (fr) | 2009-06-18 |
AR066171A1 (es) | 2009-07-29 |
CN101808996A (zh) | 2010-08-18 |
US20100222319A1 (en) | 2010-09-02 |
BRPI0817973A2 (pt) | 2019-04-09 |
AU2008334457A1 (en) | 2009-06-18 |
KR20100065165A (ko) | 2010-06-15 |
EP2205566A2 (fr) | 2010-07-14 |
TW200918056A (en) | 2009-05-01 |
CL2008002893A1 (es) | 2009-10-16 |
PA8797301A1 (es) | 2009-05-15 |
FR2921657A1 (fr) | 2009-04-03 |
RU2010116765A (ru) | 2011-11-27 |
WO2009074749A2 (fr) | 2009-06-18 |
IL204663A0 (en) | 2010-11-30 |
JP2010540504A (ja) | 2010-12-24 |
UY31367A1 (es) | 2009-04-30 |
MX2010003445A (es) | 2010-04-27 |
PE20091033A1 (es) | 2009-08-17 |
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