PA8797301A1 - Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica

Info

Publication number
PA8797301A1
PA8797301A1 PA20088797301A PA8797301A PA8797301A1 PA 8797301 A1 PA8797301 A1 PA 8797301A1 PA 20088797301 A PA20088797301 A PA 20088797301A PA 8797301 A PA8797301 A PA 8797301A PA 8797301 A1 PA8797301 A1 PA 8797301A1
Authority
PA
Panama
Prior art keywords
group
rent
hydrogen atom
nicotinamide
therapeutics
Prior art date
Application number
PA20088797301A
Other languages
English (en)
Inventor
Jerome Arigon
Claude Bernhart
Monsif Bouaboula
Pierre Casellas
Romain Combet
Sandrine Hilairet
Samir Jegham
Fraisse Pierre
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PA8797301A1 publication Critical patent/PA8797301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

LA INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA(1):EN LA QUE: A REPRESENTA UN GRUPO -NR1R'1 o ALCOXI (C1-C6), Z y Z' REPRESENTAN RESPECTIVAMENTE N Y CH ; N Y CF ; N Y N ; CH Y CH ; CH Y N; L REPRESNTA UN GRUPO -CH=CH- o -CH2CH2- o -(CH2)n-Y-; RI Y R'1 SON TAL QUE; (I) R1 REPRESENTA: -UN ÁTOMO DE HIDRÓGENO; -UN GRUPO ARILO EVENTUALMENTE SUSTITUIDO POR UNO O VARIIOS ÁTOMOS DE HALÓGENO; -UN GRUPO HETEROARILO; -UN GRUPO CICLOALQUILO (C3-C6); -UN GRUPO ALQUILO (C1-C6) Y R'1 REPRESENTA UN ÁTOMO DE HIDRÓGENO O UN GRUPO ALQUILO(C1-C6);0 (II)R1 Y R'1 FORMAN JUNTO CON EL ÁTOMO DE NITRÓGENO AL QUE ESTÁN UNIDOS UN GRUPO HETEROCICLOALQUILO; R2 REPRESENTA UN GRUPO -Q-R4; Q REPRESENTA UN ÁTOMO DE OXÍGENO O EL GRUPO -NH-. R4 REPRESENTA: -UN ÁTOMO DE HIDRÓGENO; -UN GRUPO HETEROARILO; -UN GRUPO CICLOALQUILO(C3-C6); -UN GRUPO ALQUILO(C1-C6),OPCIONALMENTE SUSTITUIDO R3 REPRESENTA AL MENOS UN SUSTITUYENTE DEL NÚCLEO PIRIDINO.
PA20088797301A 2007-09-28 2008-09-26 Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica PA8797301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0706799A FR2921657A1 (fr) 2007-09-28 2007-09-28 Derives de nicotinamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PA8797301A1 true PA8797301A1 (es) 2009-05-15

Family

ID=39356668

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088797301A PA8797301A1 (es) 2007-09-28 2008-09-26 Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica

Country Status (19)

Country Link
US (1) US20100222319A1 (es)
EP (1) EP2205566A2 (es)
JP (1) JP2010540504A (es)
KR (1) KR20100065165A (es)
CN (1) CN101808996A (es)
AR (1) AR066171A1 (es)
AU (1) AU2008334457A1 (es)
BR (1) BRPI0817973A2 (es)
CA (1) CA2700559A1 (es)
CL (1) CL2008002893A1 (es)
FR (1) FR2921657A1 (es)
IL (1) IL204663A0 (es)
MX (1) MX2010003445A (es)
PA (1) PA8797301A1 (es)
PE (1) PE20091033A1 (es)
RU (1) RU2010116765A (es)
TW (1) TW200918056A (es)
UY (1) UY31367A1 (es)
WO (1) WO2009074749A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032640T2 (en) 2005-11-08 2017-10-30 Vertex Pharma Heterocyclic modulator of ATP-binding cassette transcripts
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
CA2707494C (en) * 2007-12-07 2018-04-24 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
KR20100101130A (ko) 2007-12-07 2010-09-16 버텍스 파마슈티칼스 인코포레이티드 3-(6-(1-(2,2-디플루오로벤조[ｄ][1,3]디옥솔-5-일)사이클로프로판카복스아미도)-3-메틸피리딘-2-일)벤조산의 고체 형태
NZ602030A (en) 2008-02-28 2014-02-28 Vertex Pharma Heteroaryl derivatives as cftr modulators
FR2943675A1 (fr) * 2009-03-24 2010-10-01 Sanofi Aventis Composes anticancereux, leur preparation et leur application en therapeutique
FR2943670B1 (fr) * 2009-03-24 2011-05-06 Sanofi Aventis Derives anticancereux,leur preparation et leur application en therapeutique
FR2943669B1 (fr) * 2009-03-24 2011-05-06 Sanofi Aventis Derives de nicotinamide,leur preparation et leur application en therapeutique
CN102458402B (zh) * 2009-06-12 2013-10-02 百时美施贵宝公司 用作激酶调节剂的烟酰胺化合物
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
EP2542086A4 (en) * 2010-03-01 2013-09-04 Myrexis Inc COMPOUNDS AND ITS THERAPEUTIC USE
LT3150198T (lt) 2010-04-07 2021-12-10 Vertex Pharmaceuticals Incorporated 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties farmacinė kompozicija ir jos įvedimas
US8827372B2 (en) 2010-07-07 2014-09-09 Frontis Corp. Blowing system
FR2965263A1 (fr) * 2010-09-24 2012-03-30 Sanofi Aventis Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique
PT2573073E (pt) * 2011-09-26 2015-02-05 Sanofi Sa Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica
CN103012397B (zh) * 2011-09-26 2017-03-01 赛诺菲 吡唑并喹啉酮衍生物、其制备方法及其治疗用途
US9169246B2 (en) 2011-09-26 2015-10-27 Sanofi Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
PT3068392T (pt) 2013-11-12 2021-05-14 Vertex Pharma Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por condutância transmembrana da fibrose quística (cftr)
CN103804270B (zh) * 2014-01-23 2016-06-22 中国药科大学 5-(4-甲脒基苄氧基)色氨酸衍生物、其制法及应用
HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
CN107522641B (zh) * 2016-06-22 2020-05-05 复旦大学 联芳基脲类衍生物或其盐及其制备方法和用途
US10647665B2 (en) 2016-06-22 2020-05-12 Fudan University Biaryl urea derivative or salt thereof and preparation process and use for the same
CN112312899A (zh) * 2018-05-04 2021-02-02 治疗方案股份有限公司 靶向癌症干细胞的癌症治疗
CN110396065A (zh) * 2019-06-25 2019-11-01 南京普锐达医药科技有限公司 一种2,4-二氯-5-嘧啶甲酰氯的合成方法
US20230023124A1 (en) * 2019-11-06 2023-01-26 Remedy Plan, Inc. Cancer treatments targeting cancer stem cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4301110A1 (de) * 1993-01-18 1994-07-21 Bayer Ag Verfahren zur Herstellung von 2-Amino-5-aminomethyl-pyridin
EE200100317A (et) * 1998-12-16 2002-08-15 Bayer Aktiengesellschaft Uued bifenüül- ja bifenüülanaloogsed ühendid kui integriini antagonistid
DE10063008A1 (de) * 2000-12-16 2002-06-20 Merck Patent Gmbh Carbonsäureamidderivate
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
KR20060110307A (ko) * 2003-11-28 2006-10-24 노파르티스 아게 단백질 키나아제 의존성 질환의 치료에서의 디아릴 우레아유도체
US20060216288A1 (en) * 2005-03-22 2006-09-28 Amgen Inc Combinations for the treatment of cancer

Also Published As

Publication number Publication date
WO2009074749A2 (fr) 2009-06-18
EP2205566A2 (fr) 2010-07-14
TW200918056A (en) 2009-05-01
MX2010003445A (es) 2010-04-27
UY31367A1 (es) 2009-04-30
US20100222319A1 (en) 2010-09-02
JP2010540504A (ja) 2010-12-24
CL2008002893A1 (es) 2009-10-16
RU2010116765A (ru) 2011-11-27
PE20091033A1 (es) 2009-08-17
BRPI0817973A2 (pt) 2019-04-09
AU2008334457A1 (en) 2009-06-18
WO2009074749A3 (fr) 2009-08-20
KR20100065165A (ko) 2010-06-15
IL204663A0 (en) 2010-11-30
FR2921657A1 (fr) 2009-04-03
CN101808996A (zh) 2010-08-18
AR066171A1 (es) 2009-07-29
CA2700559A1 (fr) 2009-06-18

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