WO2008126901A1 - 含窒素複素環化合物およびそれを含有する医薬組成物 - Google Patents

含窒素複素環化合物およびそれを含有する医薬組成物 Download PDF

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WO2008126901A1
WO2008126901A1 PCT/JP2008/057095 JP2008057095W WO2008126901A1 WO 2008126901 A1 WO2008126901 A1 WO 2008126901A1 JP 2008057095 W JP2008057095 W JP 2008057095W WO 2008126901 A1 WO2008126901 A1 WO 2008126901A1
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group
pharmaceutical composition
nitrogen
disclosed
heterocyclic compound
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PCT/JP2008/057095
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French (fr)
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Norihiko Kikuchi
Yasushi Takigawa
Kazuo Shimizu
Hideki Fujikura
Masato Iizuka
Takahiro Toyoshima
Toshinobu Sasaki
Chikara Hoshino
Masakazu Takeda
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Kissei Pharmaceutical Co., Ltd.
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Priority to JP2009509374A priority Critical patent/JP5330990B2/ja
Publication of WO2008126901A1 publication Critical patent/WO2008126901A1/ja

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Urology & Nephrology (AREA)
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  • Endocrinology (AREA)
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Abstract

本発明は、キサンチンオキシダーゼ阻害作用を有する新規化合物、及びそれを有効成分として含有する医薬組成物に関する。すなわち、本発明は、下記一般式（Ｉ）で表わされる含窒素複素環化合物等（式中、Ｙ１はＮ又はＣ(Ｒ４);Ｙ２はＮ又はＣ(Ｒ５);Ｒ４及びＲ５は独立してアルキル基、水素原子等；Ｒ１及びＲ２の一方は置換可アリール基、アルコキシ基、又は置換可複素環基；Ｒ１及びＲ２の他方はハロアルキル基、シアノ基、ハロゲン原子等；Ｒ３は５－テトラゾリル基又はカルボキシ基である）またはその医薬上許容される塩、及びそれらを有効成分として含有する医薬組成物に関するものである。
PCT/JP2008/057095 2007-04-11 2008-04-10 含窒素複素環化合物およびそれを含有する医薬組成物 WO2008126901A1 (ja)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044403A1 (ja) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 ５員環ヘテロアリール誘導体及びその医薬用途
WO2010044410A1 (ja) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 ビアリールイソニコチン酸誘導体及びその医薬用途
WO2010113942A1 (ja) * 2009-03-31 2010-10-07 キッセイ薬品工業株式会社 インドリジン誘導体及びその医薬用途
US7947707B2 (en) 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
WO2012043638A1 (ja) * 2010-09-29 2012-04-05 キッセイ薬品工業株式会社 （アザ）インドリジン誘導体及びその医薬用途
JP2012188380A (ja) * 2011-03-10 2012-10-04 Meiji Univ 芳香族へテロ環化合物のニトリル化法
WO2013027801A1 (ja) * 2011-08-24 2013-02-28 キッセイ薬品工業株式会社 縮合へテロ環誘導体及びその医薬用途
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法
WO2014132994A1 (ja) * 2013-02-27 2014-09-04 キッセイ薬品工業株式会社 含窒素複素環誘導体の製造方法およびその製造中間体
EP3256449A4 (en) * 2015-02-11 2018-11-14 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers
WO2019069973A1 (ja) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN111285854A (zh) * 2018-12-07 2020-06-16 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法

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JP2000001431A (ja) * 1998-06-15 2000-01-07 Kotobuki Seiyaku Kk 尿酸排泄剤
JP3220987B2 (ja) * 1996-10-25 2001-10-22 ウェルファイド株式会社 １−フェニルピラゾール化合物およびその医薬用途
JP2005529850A (ja) * 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
WO2007043400A1 (ja) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. 含窒素芳香族複素環化合物およびそれを含有する医薬組成物

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JP3220987B2 (ja) * 1996-10-25 2001-10-22 ウェルファイド株式会社 １−フェニルピラゾール化合物およびその医薬用途
JP2000001431A (ja) * 1998-06-15 2000-01-07 Kotobuki Seiyaku Kk 尿酸排泄剤
JP2005529850A (ja) * 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
WO2007043400A1 (ja) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. 含窒素芳香族複素環化合物およびそれを含有する医薬組成物
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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947707B2 (en) 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
WO2010044410A1 (ja) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 ビアリールイソニコチン酸誘導体及びその医薬用途
WO2010044403A1 (ja) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 ５員環ヘテロアリール誘導体及びその医薬用途
US8748452B2 (en) 2009-03-31 2014-06-10 Kissei Pharmaceutical Co., Ltd. Indolizine derivative and use thereof for medical purposes
WO2010113942A1 (ja) * 2009-03-31 2010-10-07 キッセイ薬品工業株式会社 インドリジン誘導体及びその医薬用途
CN102365281A (zh) * 2009-03-31 2012-02-29 橘生药品工业株式会社 中氮茚衍生物及其医药用途
KR101772963B1 (ko) 2009-03-31 2017-08-31 깃세이 야쿠힌 고교 가부시키가이샤 인돌리진 유도체 및 그 의약용도
JP5638513B2 (ja) * 2009-03-31 2014-12-10 キッセイ薬品工業株式会社 インドリジン誘導体及びその医薬用途
CN102365281B (zh) * 2009-03-31 2014-11-12 橘生药品工业株式会社 中氮茚衍生物及其医药用途
CN103221412B (zh) * 2010-09-29 2015-08-19 橘生药品工业株式会社 (氮杂)中氮茚衍生物及其药物用途
WO2012043638A1 (ja) * 2010-09-29 2012-04-05 キッセイ薬品工業株式会社 （アザ）インドリジン誘導体及びその医薬用途
US9643969B2 (en) 2010-09-29 2017-05-09 Kissei Pharmaceutical Co., Ltd. (aza)indolizine derivative and pharmaceutical use thereof
CN103221412A (zh) * 2010-09-29 2013-07-24 橘生药品工业株式会社 （氮杂）中氮茚衍生物及其药物用途
JP5906191B2 (ja) * 2010-09-29 2016-04-20 キッセイ薬品工業株式会社 （アザ）インドリジン誘導体及びその医薬用途
JP2012188380A (ja) * 2011-03-10 2012-10-04 Meiji Univ 芳香族へテロ環化合物のニトリル化法
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法
JPWO2013027801A1 (ja) * 2011-08-24 2015-03-19 キッセイ薬品工業株式会社 縮合へテロ環誘導体及びその医薬用途
CN103889989B (zh) * 2011-08-24 2016-01-20 橘生药品工业株式会社 稠合杂环衍生物及其制药用途
WO2013027801A1 (ja) * 2011-08-24 2013-02-28 キッセイ薬品工業株式会社 縮合へテロ環誘導体及びその医薬用途
CN103889989A (zh) * 2011-08-24 2014-06-25 橘生药品工业株式会社 稠合杂环衍生物及其制药用途
US9115144B2 (en) 2011-08-24 2015-08-25 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative and pharmaceutical use thereof
WO2014132994A1 (ja) * 2013-02-27 2014-09-04 キッセイ薬品工業株式会社 含窒素複素環誘導体の製造方法およびその製造中間体
US10590078B2 (en) 2015-02-11 2020-03-17 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers
EP3256449A4 (en) * 2015-02-11 2018-11-14 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers
WO2019069973A1 (ja) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
JP2019065009A (ja) * 2017-10-04 2019-04-25 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN111148735A (zh) * 2017-10-04 2020-05-12 日本烟草产业株式会社 含氮杂芳基化合物及其药物用途
US10752596B2 (en) 2017-10-04 2020-08-25 Japan Tobacco Inc. Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
JP7125882B2 (ja) 2017-10-04 2022-08-25 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN111148735B (zh) * 2017-10-04 2023-08-08 日本烟草产业株式会社 含氮杂芳基化合物及其药物用途
CN111285854A (zh) * 2018-12-07 2020-06-16 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法
CN111285854B (zh) * 2018-12-07 2022-01-11 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法

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