WO2008120813A1 - ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用 - Google Patents

ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用 Download PDF

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Publication number
WO2008120813A1
WO2008120813A1 PCT/JP2008/056678 JP2008056678W WO2008120813A1 WO 2008120813 A1 WO2008120813 A1 WO 2008120813A1 JP 2008056678 W JP2008056678 W JP 2008056678W WO 2008120813 A1 WO2008120813 A1 WO 2008120813A1
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WO
WIPO (PCT)
Prior art keywords
sweetener
inhibitor compound
dipeptidyl peptidase
combined use
effect
Prior art date
Application number
PCT/JP2008/056678
Other languages
English (en)
French (fr)
Inventor
Masaharu Shiotani
Tomomi Ishihara
Chiaki Matsushita
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Tanabe Pharma Corporation
Priority to US12/594,568 priority Critical patent/US8927504B2/en
Priority to AU2008233548A priority patent/AU2008233548B2/en
Priority to CN2008800111647A priority patent/CN101652147B/zh
Priority to CA2682736A priority patent/CA2682736C/en
Priority to KR1020097022913A priority patent/KR101361427B1/ko
Priority to JP2009507560A priority patent/JP5616630B2/ja
Priority to ES08739785.7T priority patent/ES2529149T3/es
Priority to EP08739785.7A priority patent/EP2143443B1/en
Publication of WO2008120813A1 publication Critical patent/WO2008120813A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　優れた抗肥満効果（体脂肪減少効果　及び/または　体脂肪減少効果）を発揮する新規な治療もしくは予防方法、医薬組成物、及びそれらの使用を提供する。 　ジペプチジルペプチダーゼ４阻害化合物とＧＬＰ－１分泌促進作用を有する甘味料とを組み合わせてなる医薬組成物、並びに医薬の製造におけるその使用。また、肥満の症状を有する患者に、（ａ）ジペプチジルペプチダーゼ４阻害化合物及び（ｂ）ＧＬＰ－１分泌促進作用を有する甘味料を有効量投与することを特徴とする肥満の治療又は予防方法。
PCT/JP2008/056678 2007-04-03 2008-04-03 ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用 WO2008120813A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US12/594,568 US8927504B2 (en) 2007-04-03 2008-04-03 Combined use of dipeptidyl peptidase 4 inhibitor and sweetener
AU2008233548A AU2008233548B2 (en) 2007-04-03 2008-04-03 Combined use of dipeptidyl peptidase IV inhibitor compound and sweetener
CN2008800111647A CN101652147B (zh) 2007-04-03 2008-04-03 二肽基肽酶iv抑制化合物和甜味剂的并用
CA2682736A CA2682736C (en) 2007-04-03 2008-04-03 Combined use of dipeptidyl peptidase 4 inhibitor and sweetener
KR1020097022913A KR101361427B1 (ko) 2007-04-03 2008-04-03 디펩티딜 펩티다아제 4 저해 화합물과 감미료와의 병용
JP2009507560A JP5616630B2 (ja) 2007-04-03 2008-04-03 ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用
ES08739785.7T ES2529149T3 (es) 2007-04-03 2008-04-03 Una combinación de inhibidor de dipeptidil peptidasa IV y edulcorante para uso en el tratamiento de la obesidad
EP08739785.7A EP2143443B1 (en) 2007-04-03 2008-04-03 A combination of dipeptidyl peptidase iv inhibitor and sweetener for use in the treatment of obesity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90747107P 2007-04-03 2007-04-03
JP2007097079 2007-04-03
JP2007-097079 2007-04-03
US60/907,471 2007-04-03

Publications (1)

Publication Number Publication Date
WO2008120813A1 true WO2008120813A1 (ja) 2008-10-09

Family

ID=39808393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056678 WO2008120813A1 (ja) 2007-04-03 2008-04-03 ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用

Country Status (9)

Country Link
US (1) US8927504B2 (ja)
EP (1) EP2143443B1 (ja)
JP (2) JP5616630B2 (ja)
KR (2) KR101361427B1 (ja)
CN (2) CN103330939A (ja)
AU (1) AU2008233548B2 (ja)
CA (1) CA2682736C (ja)
ES (1) ES2529149T3 (ja)
WO (1) WO2008120813A1 (ja)

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WO2010039124A1 (en) * 2008-09-30 2010-04-08 Mitsubishi Tanabe Pharma Corporation Benzenesulfonic acid salt compounds
WO2011068150A1 (ja) * 2009-12-04 2011-06-09 株式会社東洋新薬 グルカゴン様ペプチド－１分泌促進剤
JP2011173798A (ja) * 2010-02-23 2011-09-08 Yakult Honsha Co Ltd 腸間膜脂肪低減剤
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2011207834A (ja) * 2010-03-30 2011-10-20 Shizuokaken Koritsu Daigaku Hojin Ｇｐｒ４３陽性・腸内分泌細胞増加促進剤
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2012236849A (ja) * 2007-04-03 2012-12-06 Mitsubishi Tanabe Pharma Corp ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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JP2013525471A (ja) * 2010-05-05 2013-06-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
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WO2021153718A1 (ja) * 2020-01-31 2021-08-05 国立大学法人京都大学 線維芽細胞増殖因子２１誘導剤、及びアルコール嗜好性又は単純糖質嗜好性を抑制するための組成物
JP2021161069A (ja) * 2020-03-31 2021-10-11 花王株式会社 食後血中中性脂肪上昇抑制剤
JP2021161070A (ja) * 2020-03-31 2021-10-11 花王株式会社 Ｇｌｐ−１分泌促進剤

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