WO2008114673A1 - ポリペプチドの製造方法 - Google Patents
ポリペプチドの製造方法 Download PDFInfo
- Publication number
- WO2008114673A1 WO2008114673A1 PCT/JP2008/054579 JP2008054579W WO2008114673A1 WO 2008114673 A1 WO2008114673 A1 WO 2008114673A1 JP 2008054579 W JP2008054579 W JP 2008054579W WO 2008114673 A1 WO2008114673 A1 WO 2008114673A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- producing
- polypeptide
- disclosed
- dna encoding
- cysteine sulfinate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01029—Sulfinoalanine decarboxylase (4.1.1.29)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
天然型タンパク質又は組換えタンパク質を高生産量で製造することができる方法を提供する。 システインスルフィン酸デカルボキシラーゼを強発現し、且つ所望のポリペプチドをコードするDNAを導入した細胞を培養し、所望のポリペプチドを産生させることを含む、ポリペプチドの製造方法。ハムスターシステインスルフィン酸デカルボキシラーゼ、それをコードするDNA、組換えベクター及び形質転換細胞なども提供される。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009505163A JP5635260B2 (ja) | 2007-03-15 | 2008-03-13 | ポリペプチドの製造方法 |
US12/450,161 US20100233759A1 (en) | 2007-03-15 | 2008-03-13 | Method for production of polypeptide |
EP08738650.4A EP2135946B1 (en) | 2007-03-15 | 2008-03-13 | Method for production of polypeptide |
US13/368,945 US8796007B2 (en) | 2007-03-15 | 2012-02-08 | Method for production of polypeptide |
US14/449,259 US9181540B2 (en) | 2007-03-15 | 2014-08-01 | Method for production of polypeptide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-066172 | 2007-03-15 | ||
JP2007066172 | 2007-03-15 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/450,161 A-371-Of-International US20100233759A1 (en) | 2007-03-15 | 2008-03-13 | Method for production of polypeptide |
US13/368,945 Continuation US8796007B2 (en) | 2007-03-15 | 2012-02-08 | Method for production of polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008114673A1 true WO2008114673A1 (ja) | 2008-09-25 |
Family
ID=39765781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/054579 WO2008114673A1 (ja) | 2007-03-15 | 2008-03-13 | ポリペプチドの製造方法 |
Country Status (5)
Country | Link |
---|---|
US (3) | US20100233759A1 (ja) |
EP (1) | EP2135946B1 (ja) |
JP (1) | JP5635260B2 (ja) |
TW (1) | TW200904977A (ja) |
WO (1) | WO2008114673A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009051109A1 (ja) * | 2007-10-15 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | 異種タンパク質を高生産する細胞の作製方法 |
WO2010123014A1 (ja) | 2009-04-22 | 2010-10-28 | 中外製薬株式会社 | 異種タンパク質を高生産する細胞の作製方法 |
WO2012137683A1 (ja) | 2011-04-01 | 2012-10-11 | 中外製薬株式会社 | 組換えポリペプチドの製造方法 |
US8697397B2 (en) | 2007-08-07 | 2014-04-15 | Chugai Seiyaku Kabushiki Kaisha | Method of producing heterogeneous protein |
WO2014058025A1 (ja) | 2012-10-10 | 2014-04-17 | 中外製薬株式会社 | 改変宿主細胞の樹立方法 |
US8796007B2 (en) | 2007-03-15 | 2014-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method for production of polypeptide |
US9068212B2 (en) | 2007-10-24 | 2015-06-30 | Chugai Seiyaku Kabushiki Kaisha | Method for producing a polypeptide using a cell that overexpresses a bicarbonate transporter |
US9238687B2 (en) | 2006-04-13 | 2016-01-19 | Chugai Seiyaku Kabushiki Kaisha | Method for recombinant production of a desired polypeptide using a mammalian cell co-expressing a taurine transporter polypeptide |
WO2017213142A1 (ja) * | 2016-06-07 | 2017-12-14 | 味の素株式会社 | ヒポタウリンまたはタウリンの製造法 |
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US20140082761A1 (en) * | 2011-05-18 | 2014-03-20 | Plant Sensory Systems, Llc | Methods to increase plant productivity |
US20160046954A1 (en) * | 2014-08-18 | 2016-02-18 | Plant Sensory Systems, Llc | Methods to improve crops through increased accumulation of methionine |
US20170283821A1 (en) * | 2014-10-10 | 2017-10-05 | Plant Sensory Systems, Llc. | Methods to improve plant-based food and feed |
CN112779243B (zh) * | 2019-11-08 | 2024-02-02 | 浙江工业大学 | 一种L-天冬氨酸-α-脱羧酶及其应用 |
US20230106023A1 (en) | 2020-02-18 | 2023-04-06 | Boehringer Ingelheim International Gmbh | Mammalian cell culture processes |
CN111187351B (zh) * | 2020-04-14 | 2020-08-04 | 浙江恒驭生物科技有限公司 | 一种肝癌检测试剂盒 |
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WO2006006693A1 (ja) | 2004-07-09 | 2006-01-19 | Chugai Seiyaku Kabushiki Kaisha | 抗グリピカン3抗体 |
JP2006506086A (ja) * | 2002-11-17 | 2006-02-23 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | 神経変性障害を治療するための方法、核酸構築物および細胞 |
JP2007066172A (ja) | 2005-09-01 | 2007-03-15 | Canon Inc | データ処理方法、データ処理装置 |
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-
2008
- 2008-03-13 JP JP2009505163A patent/JP5635260B2/ja active Active
- 2008-03-13 EP EP08738650.4A patent/EP2135946B1/en active Active
- 2008-03-13 WO PCT/JP2008/054579 patent/WO2008114673A1/ja active Application Filing
- 2008-03-13 US US12/450,161 patent/US20100233759A1/en not_active Abandoned
- 2008-03-17 TW TW097109377A patent/TW200904977A/zh unknown
-
2012
- 2012-02-08 US US13/368,945 patent/US8796007B2/en active Active
-
2014
- 2014-08-01 US US14/449,259 patent/US9181540B2/en active Active
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Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9238687B2 (en) | 2006-04-13 | 2016-01-19 | Chugai Seiyaku Kabushiki Kaisha | Method for recombinant production of a desired polypeptide using a mammalian cell co-expressing a taurine transporter polypeptide |
US8796007B2 (en) | 2007-03-15 | 2014-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method for production of polypeptide |
US9181540B2 (en) | 2007-03-15 | 2015-11-10 | Chugai Seiyaku Kabushiki Kaisha | Method for production of polypeptide |
US9499618B2 (en) | 2007-08-07 | 2016-11-22 | Chugai Seiyaku Kabushiki Kaisha | Method of producing heterogeneous protein |
US9284374B2 (en) | 2007-08-07 | 2016-03-15 | Chugai Seiyaku Kabushiki Kaisha | Method of producing heterogeneous protein |
US8697397B2 (en) | 2007-08-07 | 2014-04-15 | Chugai Seiyaku Kabushiki Kaisha | Method of producing heterogeneous protein |
US9802993B2 (en) | 2007-10-15 | 2017-10-31 | Chugai Seiyaku Kabushiki Kaisha | Method for producing a cell for protein production by treating a cell overexpressing a taurine transporter with methotrexate |
JP5337043B2 (ja) * | 2007-10-15 | 2013-11-06 | 中外製薬株式会社 | 異種タンパク質を高生産する細胞の作製方法 |
WO2009051109A1 (ja) * | 2007-10-15 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | 異種タンパク質を高生産する細胞の作製方法 |
US9068212B2 (en) | 2007-10-24 | 2015-06-30 | Chugai Seiyaku Kabushiki Kaisha | Method for producing a polypeptide using a cell that overexpresses a bicarbonate transporter |
US8741601B2 (en) | 2009-04-22 | 2014-06-03 | Chugai Seiyaku Kabushiki Kaisha | Method for producing a cell capable of high-yield production of heteroproteins |
WO2010123014A1 (ja) | 2009-04-22 | 2010-10-28 | 中外製薬株式会社 | 異種タンパク質を高生産する細胞の作製方法 |
WO2012137683A1 (ja) | 2011-04-01 | 2012-10-11 | 中外製薬株式会社 | 組換えポリペプチドの製造方法 |
US11905325B2 (en) | 2011-04-01 | 2024-02-20 | Chugai Seiyaku Kabushiki Kaisha | Recombinant polypeptide production method |
JPWO2012137683A1 (ja) * | 2011-04-01 | 2014-07-28 | 中外製薬株式会社 | 組換えポリペプチドの製造方法 |
US11028149B2 (en) | 2011-04-01 | 2021-06-08 | Chugai Seiyaku Kabushiki Kaisha | Recombinant polypeptide production method |
CN103459608A (zh) * | 2011-04-01 | 2013-12-18 | 中外制药株式会社 | 重组多肽的制造方法 |
JPWO2014058025A1 (ja) * | 2012-10-10 | 2016-09-05 | 中外製薬株式会社 | 改変宿主細胞の樹立方法 |
KR20150065812A (ko) | 2012-10-10 | 2015-06-15 | 추가이 세이야쿠 가부시키가이샤 | 개변 숙주 세포의 수립 방법 |
KR20210014223A (ko) | 2012-10-10 | 2021-02-08 | 추가이 세이야쿠 가부시키가이샤 | 개변 숙주 세포의 수립 방법 |
WO2014058025A1 (ja) | 2012-10-10 | 2014-04-17 | 中外製薬株式会社 | 改変宿主細胞の樹立方法 |
US11608508B2 (en) | 2012-10-10 | 2023-03-21 | Chugai Seiyaku Kabushiki Kaisha | Method for establishing modified host cell |
CN104718291A (zh) * | 2012-10-10 | 2015-06-17 | 中外制药株式会社 | 经修饰的宿主细胞的建立方法 |
WO2017213142A1 (ja) * | 2016-06-07 | 2017-12-14 | 味の素株式会社 | ヒポタウリンまたはタウリンの製造法 |
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EP2135946A4 (en) | 2010-10-13 |
US9181540B2 (en) | 2015-11-10 |
EP2135946B1 (en) | 2015-12-09 |
EP2135946A1 (en) | 2009-12-23 |
US20100233759A1 (en) | 2010-09-16 |
JP5635260B2 (ja) | 2014-12-03 |
US8796007B2 (en) | 2014-08-05 |
US20140335565A1 (en) | 2014-11-13 |
US20120142057A1 (en) | 2012-06-07 |
JPWO2008114673A1 (ja) | 2010-07-01 |
TW200904977A (en) | 2009-02-01 |
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