WO2008099778A1 - スリット走査共焦点顕微鏡 - Google Patents

スリット走査共焦点顕微鏡 Download PDF

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Publication number
WO2008099778A1
WO2008099778A1 PCT/JP2008/052123 JP2008052123W WO2008099778A1 WO 2008099778 A1 WO2008099778 A1 WO 2008099778A1 JP 2008052123 W JP2008052123 W JP 2008052123W WO 2008099778 A1 WO2008099778 A1 WO 2008099778A1
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WO
WIPO (PCT)
Prior art keywords
slit
light source
confocal microscope
scanning confocal
light
Prior art date
Application number
PCT/JP2008/052123
Other languages
English (en)
French (fr)
Inventor
Tomoko Ujike
Original Assignee
Nikon Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikon Corporation filed Critical Nikon Corporation
Priority to EP08711002A priority Critical patent/EP2124085A4/en
Priority to JP2008558072A priority patent/JPWO2008099778A1/ja
Publication of WO2008099778A1 publication Critical patent/WO2008099778A1/ja
Priority to US12/541,858 priority patent/US20100202043A1/en

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Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/16Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Abstract

 スリット走査共焦点顕微鏡は、スリット状の光源1と、光源1の像を試料3の上に結像させる照明光学系2と、試料3からの反射光、透過光又は蛍光を、光源1と光学的に共役な位置に配置された1次元撮像素子5上に結像させる結像光学系4とを有する。スリット状の光源1は、1次元撮像素子5の画素と光学的に共役な大きさの単位光源に分割されている。
PCT/JP2008/052123 2007-02-14 2008-02-08 スリット走査共焦点顕微鏡 WO2008099778A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08711002A EP2124085A4 (en) 2007-02-14 2008-02-08 CONFOCAL SLOTTED SCANNING MICROSCOPE
JP2008558072A JPWO2008099778A1 (ja) 2007-02-14 2008-02-08 スリット走査共焦点顕微鏡
US12/541,858 US20100202043A1 (en) 2007-02-14 2009-08-14 Slit-scanning confocal microscope

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007033397 2007-02-14
JP2007-033397 2007-02-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/541,858 Continuation US20100202043A1 (en) 2007-02-14 2009-08-14 Slit-scanning confocal microscope

Publications (1)

Publication Number Publication Date
WO2008099778A1 true WO2008099778A1 (ja) 2008-08-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052123 WO2008099778A1 (ja) 2007-02-14 2008-02-08 スリット走査共焦点顕微鏡

Country Status (4)

Country Link
US (1) US20100202043A1 (ja)
EP (1) EP2124085A4 (ja)
JP (1) JPWO2008099778A1 (ja)
WO (1) WO2008099778A1 (ja)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
CN102782480B (zh) 2010-03-01 2013-09-11 奥林巴斯株式会社 光学分析装置、光学分析方法和用于光学分析的计算机程序
TWI414817B (zh) 2010-07-23 2013-11-11 Univ Nat Taipei Technology 線型彩色共焦顯微系統
EP2584343B1 (en) 2010-07-26 2017-05-10 Olympus Corporation Method for detecting dilute particles in solution using luminescent probe
JP5893564B2 (ja) 2010-09-10 2016-03-23 オリンパス株式会社 複数の波長帯域の光計測を用いた光分析方法
CN103097878B (zh) 2010-09-10 2015-07-22 奥林巴斯株式会社 使用单个发光颗粒的光强度的光学分析方法
CN103210302B (zh) 2010-10-19 2015-05-27 奥林巴斯株式会社 观测单个发光粒子的偏振特性的光分析装置、光分析方法
EP2631631B1 (en) 2010-11-25 2016-01-20 Olympus Corporation Photometric analysis device and photometric analysis method using wavelength characteristic of light emitted from single illuminant particle
WO2012099234A1 (ja) 2011-01-20 2012-07-26 オリンパス株式会社 単一発光粒子からの光の検出を用いた光分析方法及び光分析装置
CN103328956B (zh) 2011-01-26 2015-08-12 奥林巴斯株式会社 鉴别核酸分子多态性的方法
EP2669376B1 (en) 2011-01-26 2017-08-16 Olympus Corporation Method for identifying polymorphism of nucleic acid molecules
JP5904996B2 (ja) 2011-03-29 2016-04-20 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法並びに光分析用コンピュータプログラム
WO2012141019A1 (ja) 2011-04-13 2012-10-18 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
WO2012144528A1 (ja) 2011-04-18 2012-10-26 オリンパス株式会社 標的粒子の定量方法、光分析装置及び光分析用コンピュータプログラム
WO2013021687A1 (ja) 2011-08-11 2013-02-14 オリンパス株式会社 標的粒子の検出方法
JP6013337B2 (ja) 2011-08-15 2016-10-25 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
EP2749868B1 (en) 2011-08-26 2019-02-27 Olympus Corporation Single-particle detector using optical analysis, single-particle detection method using same, and computer program for single-particle detection
EP2749867B1 (en) 2011-08-26 2017-05-10 Olympus Corporation Optical analysing device and method using individual light-emitting particle detection
CN103765194B (zh) 2011-08-30 2016-02-17 奥林巴斯株式会社 目标粒子的检测方法
JP6010035B2 (ja) 2011-08-30 2016-10-19 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
JP5941923B2 (ja) 2011-11-10 2016-06-29 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN104115001B (zh) 2012-02-17 2016-08-24 奥林巴斯株式会社 利用单个粒子检测的光分析装置、光分析方法
JP5940644B2 (ja) 2012-02-22 2016-06-29 オリンパス株式会社 標的粒子の検出方法
WO2013140890A1 (ja) 2012-03-21 2013-09-26 オリンパス株式会社 標的核酸分子の検出方法
EP2840381B1 (en) 2012-04-18 2017-08-09 Olympus Corporation Method for detecting target particles
JP6010114B2 (ja) 2012-04-18 2016-10-19 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
FI125408B (fi) 2012-09-17 2015-09-30 Focalspec Oy Menetelmä ja mittalaite pinnan etäisyyden, kohteen paksuuden ja optisten ominaisuuksien mittaamiseksi
EP3029505A4 (en) 2013-07-31 2017-03-15 Olympus Corporation Optical microscope device, microscopy method, and computer program for microscopy using single-light-emitting-particle detection technology
JP6313776B2 (ja) 2013-10-07 2018-04-18 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
WO2017098597A1 (ja) 2015-12-09 2017-06-15 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05188301A (ja) * 1991-09-09 1993-07-30 Sumitomo Electric Ind Ltd レーザ顕微鏡
JP2004219537A (ja) * 2003-01-10 2004-08-05 Nikon Engineering Co Ltd 共焦点顕微鏡

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028802A (en) * 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5107113A (en) * 1990-12-26 1992-04-21 Bell Communications Research, Inc. Method and apparatus for correcting distortions in scanning tunneling microscope images
US5563710A (en) * 1994-10-28 1996-10-08 The Schepens Eye Research Institute, Inc. Imaging system with confocally self-detecting laser
US6121603A (en) * 1997-12-01 2000-09-19 Hang; Zhijiang Optical confocal device having a common light directing means
US6399936B1 (en) * 1997-12-01 2002-06-04 New Dimension Research Instrument, Inc. Optical confocal device having a common light directing means
US6784982B1 (en) * 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6987259B2 (en) * 2002-05-30 2006-01-17 Dmetrix, Inc. Imaging system with an integrated source and detector array
FR2849215B1 (fr) * 2002-12-20 2005-03-11 Mauna Kea Technologies Systeme de microscopie laser confocale parallele basee sur la technologie vcsel
DE102004016253B4 (de) * 2004-04-02 2006-02-23 Leica Microsystems Cms Gmbh Rastermikroskop und Verfahren zur rastermikroskopischen Untersuchung einer Probe
DE102004020663A1 (de) * 2004-04-24 2005-11-10 Carl Zeiss Meditec Ag Einrichtung zur Beleuchtung organischer Objekte
JP4894161B2 (ja) * 2005-05-10 2012-03-14 株式会社ニコン 共焦点顕微鏡
EP1996909A4 (en) * 2006-03-09 2013-01-23 Tessarae Llc MICROARRAY IMAGING SYSTEM AND CORRESPONDING METHODS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05188301A (ja) * 1991-09-09 1993-07-30 Sumitomo Electric Ind Ltd レーザ顕微鏡
JP2004219537A (ja) * 2003-01-10 2004-08-05 Nikon Engineering Co Ltd 共焦点顕微鏡

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2124085A4 *
TADAO TSURUTA: "Light Pencil", NEW TECHNOLOGY COMMUNICATIONS, pages: 177 - 205

Also Published As

Publication number Publication date
JPWO2008099778A1 (ja) 2010-05-27
EP2124085A1 (en) 2009-11-25
EP2124085A4 (en) 2010-04-28
US20100202043A1 (en) 2010-08-12

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