WO2008029280A2 - Dispositif d'injection automatique équipé de moyens de temporisation - Google Patents

Dispositif d'injection automatique équipé de moyens de temporisation Download PDF

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Publication number
WO2008029280A2
WO2008029280A2 PCT/IB2007/003451 IB2007003451W WO2008029280A2 WO 2008029280 A2 WO2008029280 A2 WO 2008029280A2 IB 2007003451 W IB2007003451 W IB 2007003451W WO 2008029280 A2 WO2008029280 A2 WO 2008029280A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
plunger rod
piston
needle
housing
Prior art date
Application number
PCT/IB2007/003451
Other languages
English (en)
Other versions
WO2008029280A3 (fr
Inventor
Hervé ABRY
Franck Carrel
Guillaume Grunhut
Lionel Maritan
Frédéric PEROT
Original Assignee
Becton Dickinson France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40219929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008029280(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES07848874.9T priority Critical patent/ES2643939T3/es
Priority to EP07848874.9A priority patent/EP2076299B1/fr
Priority to US12/440,145 priority patent/US7976514B2/en
Priority to JP2009527225A priority patent/JP5202529B2/ja
Priority to EP17179230.2A priority patent/EP3254715B9/fr
Application filed by Becton Dickinson France filed Critical Becton Dickinson France
Priority to EP17179232.8A priority patent/EP3254716B1/fr
Priority to EP17179236.9A priority patent/EP3257537B1/fr
Publication of WO2008029280A2 publication Critical patent/WO2008029280A2/fr
Publication of WO2008029280A3 publication Critical patent/WO2008029280A3/fr
Priority to US13/152,336 priority patent/US8435215B2/en
Priority to US13/864,881 priority patent/US9486582B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
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    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
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    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
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    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
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    • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • A—HUMAN NECESSITIES
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    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433—Ampoule fixed to ampoule holder
    • A61M2005/2437—Ampoule fixed to ampoule holder by clamping means
    • A61M2005/244—Ampoule fixed to ampoule holder by clamping means by flexible clip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3261—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user triggered by radial deflection of the anchoring parts between sleeve and syringe barrel, e.g. spreading of sleeve retaining hooks having slanted surfaces by engagement with conically shaped collet of the piston rod during the last portion of the injection stroke of the plunger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/19—Constructional features of carpules, syringes or blisters
    • A61M2205/192—Avoiding coring, e.g. preventing formation of particles during puncture
    • A—HUMAN NECESSITIES
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/008—Racks for supporting syringes or needles
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A—HUMAN NECESSITIES
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    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
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    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices

Definitions

  • the present invention relates to a device for automatic injection of a product in a very safe way, especially for self-injection.
  • the distal end of a component or of a device is to be understood as meaning the end furthest from the user's hand and the proximal end is to be understood as meaning the end closest to the user's hand.
  • the distal direction is to be understood as meaning the direction of injection
  • the proximal direction is to be understood as meaning the opposite direction to the direction of injection.
  • Some illnesses necessitate regular injections of drugs or products, for instance on a daily basis.
  • some self- injectors have been provided in order to allow the patient to perform the injection on its own.
  • the insertion of the needle must be performed at the right depth, the correct dose of product must be injected, that is to say a complete injection must be performed, and the injector must be deactivated after use before it is disposed of.
  • the needle should not be exposed, before and after use, in order to prevent any accidental needlestick injury.
  • some devices are provided with a sleeve that extends over the needle once the user has removed the device from the injection site.
  • the needle may be automatically retracted within the device at the end of injection with no further action from the user. Therefore, when the user withdraws the device from the injection site, the needle is already retracted within the device and the user does not take the risk to hurt himself.
  • the present invention meets this need by proposing a device for automatic injection of a product into an injection site, said device allowing both the retraction of the needle at the end of an automatically driven injection and the complete injection of the product.
  • the present invention relates to a device for automatic injection of a product into an injection site, the injection device comprising:
  • a container having an open proximal end and a substantially closed distal end and being intended to receive the product, and provided at its distal end with an injection needle providing an outlet port of said container,
  • - a housing intended to receive, at least partially, said container, said container being movable relative to said housing between an initial position, in which said needle is contained within said housing, an insertion position, distally spaced relative to said initial position and in which said needle is exposed over a predetermined length, and a final position in which said needle is contained within said housing, - retaining means, arranged to maintain said container in said insertion position,
  • - deactivating means arranged to release automatically said retaining means and cause said container to move to said final position
  • said device being characterized in that it further comprises : - temporizing means, arranged to control the release of said retaining means by said deactivating means until substantially all of the product contained within said container has been caused to pass through said outlet port and said injection needle before said container moves to said final position, and a needle shield coupled with said housing and covering the needle prior to use of said device, removal of said needle shield being with limited or no rotation of said needle shield.
  • the device of the invention allows that the needle shield be removed before use of the device with limited or no rotation of the needle shield. In consequence, the potential rotation of the tip of the needle within the rubber forming the needle shield is avoided and the core that could result from such a potential rotation is also avoided. The integrity and sterility of the needle are therefore preserved and the administration do the product can be completed safely.
  • the device of the invention allows the injection of the totality of the product before the needle is retracted. Thanks to the temporizing means of the device of the invention, the retraction of the needle is not triggered when some product is still present at the bottom of the container of the injection device. Some time, for instance between 1 to 10 seconds, is allowed before the retraction of the needle is triggered.
  • the device of the invention is therefore very safe and very simple of use. The user only needs to apply the device on the injection site and then activate the first deactivating means to start the operation. At the end of the complete injection, and only when all of the product is injected, the needle is retracted within the device and the user can withdraw the device from the injection site without any risk.
  • said housing is coupled to a deshielder comprising a cap to which is fixed said needle shield, said housing comprising grooves for guiding the translation of said cap when said cap is removed together with the removal of said deshielder in view of using said device.
  • said temporizing means comprises a chamber comprising a vent outlet, said chamber being tightly closed by a sealing cover in an initial state, and defining an initial volume of said chamber and in which a determined amount of fluid is contained within said initial volume, said sealing cover being movable within said chamber from said initial state to a final state in which at least part of said fluid has escaped through said vent outlet.
  • Said vent outlet may be a simple hole, with a small diameter.
  • said diameter may range from 15 micrometer to 25 micrometer.
  • said vent outlet may be an exhaust valve comprising a membrane allowing the passage of the fluid.
  • Said membrane may be made of a material selected from the group comprising polytetrafluoroethylene, polyethylene, paper, tissue, foam, porous plastic, and combinations thereof. The diameter of said membrane may be about 1 mm.
  • Said fluid may be a gas, like air.
  • said fluid is pressurized.
  • said fluid may be a viscous liquid, like oil or grease.
  • said device further comprises elastic return means coupled to said chamber for moving said sealing cover from said initial state to said final state, said deactivating means being coupled to said chamber so that said deactivating means releases said retaining means only when said sealing cover is in said final state.
  • said chamber comprises the proximal part of a sleeve having a closed proximal end and an open distal end, said closed proximal end comprising a vent outlet and said open distal end comprising an outer radial rim
  • said device further comprising a piston provided in said container and movable with respect to said container, and a plunger rod coupled to said piston so as to cause said piston to move with respect to said container, the movement of said piston causing said product to be expelled from said container through said injection needle, - said sealing cover, in its initial state, closing the inner proximal space of said sleeve thereby defining said chamber, said sealing cover being coupled to said plunger rod,
  • said device further comprises first elastic return means coupled to said housing for moving said container from said initial position to said insertion position, second elastic return means coupled to said housing for moving said container from said insertion position to said final position, and a ring, said ring being coupled to said container at least from said insertion position to said final position of said container, - said retaining means comprises a flexible tongue provided on said housing and engaged on an abutment surface situated on said ring, when said container is in said insertion position,
  • the device of the invention further comprises first retaining means, arranged to maintain said container in said initial position, and first deactivating means, arranged to release said first retaining means and cause the insertion of said needle at the injection site, wherein said first retaining means comprises a flexible tooth provided on said housing, said flexible tooth being engaged with said outer radial rim of said sleeve when said container is in said initial position,
  • said first deactivating means comprises a push button comprising at least one distal leg
  • said distal leg cooperating with at least said flexible tooth so as to deflect and disengage said flexible tooth from said outer radial rim, under the effect of a manual pressure exerted on said push button, thereby freeing said first elastic return means and causing said container to move from said initial position to said insertion position.
  • said sleeve forms said first deactivating means
  • said first retaining means comprising an outer projection provided on said sleeve, said outer projection being in abutment against a stop provided on said housing and preventing the distal translation of said sleeve when said container is in said initial position, said stop being able to be overcome by said outer projection under manual pressure exerted on said sleeve, thereby freeing said first elastic return means and causing said container to move from said initial position to said insertion position.
  • said device further comprises a piston provided in said container and movable with respect to said container, a plunger rod coupled to said piston so as to cause said piston to move with respect to said container, the movement of said piston causing said product to be expelled from said container through said injection needle, second elastic return means coupled to said housing for moving said container from said insertion position to said final position, and automatic injection means, arranged to automatically cause said plunger rod to push distally said piston,
  • said deactivating means being formed on the proximal part of said plunger rod and said retaining means being partly formed on said housing,
  • said plunger rod being provided in two parts, a proximal part and a distal part, when said piston comes into contact with the distal end of said container, under the force exerted by said automatic injection means on the proximal part of said plunger rod, wherein said distal part of said plunger rod is thereby stopped and said proximal part of said plunger is allowed to continue its distal movement under the force exerted by said automatic injection means for a certain time until said deactivating means cooperate with said retaining means to cause said container to move from said insertion position to said final position, said proximal part of said plunger rod forming part of said temporizing means.
  • said device further comprises a ring, said ring being coupled to said container when said container moves from said insertion position to said final position,
  • said retaining means comprises a radially flexible leg situated on the inner wall of said housing, engaged on an abutment surface of said ring, when said container is in said insertion position,
  • said deactivating means comprises a head of said proximal part of said plunger rod, said plunger rod head deflecting said radially flexible leg under the force exerted by said automatic injection means, thereby disengaging said radially flexible leg from said abutment surface, freeing said second elastic return means and causing said container to move from said insertion position to said final position.
  • said distal part of said plunger rod comprises a cylinder capable of receiving a portion of said proximal part of said plunger rod, and said distal part of said plunger rod comprises softening means designed for reducing the speed of the distal movement of said proximal part of said plunger rod within said distal part of said plunger rod.
  • said softening means comprise a rubbery material coated on the inner wall of said cylinder, said proximal part of said plunger rod being provided at its distal end with at least one radial projection that contacts said rubbery material as said proximal part of said plunger rod moves distally.
  • said softening means comprise a compressible material provided at the bottom of said cylinder, the speed of said proximal part of said plunger rod being reduced when the distal end of said proximal part of said plunger rod comes in contact with said compressible material.
  • Said compressible material may be a spring.
  • the inner diameter of said cylinder decreases towards the bottom of said cylinder and the distal end of said proximal part of said plunger rod is provided with flexible tongues that rub against the inner walls of said cylinder as said proximal part of said plunger rod moves distally.
  • the inner walls of said cylinder are provided with longitudinal flexible legs that come in contact with a radial projection provided at the distal end of said proximal part of said plunger rod, thereby reducing the speed of said proximal part of said plunger rod, as said proximal part of said plunger rod moves distally.
  • said inner walls of said cylinder are provided with a thread which cooperates with a screw provided at the distal end of said proximal part of said plunger rod, thereby reducing the speed of said proximal part of said plunger rod, as said proximal part of said plunger rod moves distally.
  • said cylinder walls are provided with a number of steps and the distal end of said proximal part of said plunger rod is provided with a number of radial flaps, the number of radial flaps that interact with said steps increasing as said proximal part of said plunger rod moves distally.
  • the more the proximal part of said plunger rod moves distally the greater is the resistance force resulting from the interaction of the flaps with the steps.
  • the proximal part of the plunger rod is therefore slowed down and some time is therefore allowed for the totality of the product to be expelled before the container is caused to move to its final position.
  • the device further comprises first retaining means arranged to maintain said container in said initial position, and first deactivating means arranged to release said first retaining means and cause the insertion of said needle at the injection site, wherein said first deactivating means are manually actuated.
  • the device further comprises means for indicating to a user that substantially all of the product contained within said container has been caused to pass through said outlet port and said injection needle.
  • the device further comprises tamper-evidence means removably coupled with said housing to shield said needle prior to use of said device, said tamper-evidence means being in one of a pre-use condition and a post-use condition, said post-use condition preventing re-use of said tamper evidence means with said device.
  • said post-use condition provides a visual indication that said tamper evidence means has been removed from said device.
  • said tamper-evidence means comprises a deshielder and a needle shield, said post-use condition proving an indication that said temper-evidence means has been removed from said device.
  • the device further comprises a needle shield coupled with said housing and covering the needle prior to use of said device, removal of said needle shield being with limited or no rotation of said needle shield.
  • said device further comprising a piston provided in said container and movable within said container, the distal movement of said piston causing said product to be expelled from said container through said injection needle,
  • said chamber being partly defined by the inner part of the container situated proximally to said piston and partly defined by the proximal part of said housing, said sealing cover joining the proximal end of said inner part to said housing through a friction force of absolute value F, - said chamber being filled in said initial state of said sealing cover with a pressurized fluid exerting a pressure of absolute value Pc on said container in the distal direction, with the intermediary of the piston,
  • said device further comprising elastic return means for moving said container from the insertion position to the final position, said elastic return means being coupled to said container so as to exert on said container a return force of absolute value Pe when said elastic return means is at least in a partly compressed state,
  • said pressurized fluid is provided to said chamber from a recipient present within said chamber, said recipient being sealingly closed when said container is in its initial position, said device being provided with a puncturing button capable of creating an opening in said recipient when a manual force is exerted on said puncturing button, said pressurized fluid being then allowed to escape from said recipient and to fill said chamber.
  • said sealing cover is porous and forms said vent outlet.
  • said device further comprises:
  • said chamber is defined by the volume delimited by the inner part of the container situated proximally to said piston, the wall of the housing and the head of the piston rod, the proximal end of said container joining the wall of the housing via a first porous sealing cover and the head of the piston rod joining the wall of the housing via a second porous sealing cover.
  • the two sealing covers present a friction force against the wall of said housing of absolute value F, - said chamber is filled in the initial state of said second sealing cover with a pressurized fluid exerting a pressure of absolute value Pc on said container in the distal direction, with the intermediary of the piston,
  • said device further comprising first elastic return means for moving said container from the initial position to the insertion position, said first elastic return means being coupled to said piston rod so as to exert on said piston rod a return force of absolute value Pi when said first elastic return means is at least in a partly compressed state,
  • said device further comprising second elastic return means for moving said container from the insertion position to the final position, said second elastic return means being coupled to said container so as to exert on said container a return force of absolute value Pe when said second elastic return means is at least in a partly compressed state, wherein (Pc + Pi) is greater than (Pe + F) in the initial sate of said second sealing cover, wherein Pc decreases as part of the pressurized fluid is escaping the chamber via the vent outlet, said retaining means are formed by (Pc + Pi) being greater than (Pe + F), said retaining means being released when Pe becomes equal or greater than (Pc + F + Pi).
  • the deactivating means comprise a valve situated on said first porous sealing cover, said valve being closed when said second porous sealing cover is in its initial state and opened when said second porous sealing cover is in its final state, the opening of said valve releasing part of said retaining means.
  • kits for a device for automatic injection of a product into an injection site the product being carried by a container having an open proximal end and a substantially closed distal end and having a reservoir defined therebetween, and a needle provided at the distal end and in fluid communication with the reservoir to provide an outlet port for the product from the container, and a piston provided in the container and movable with respect with the container, the movement of the piston causing the product to be expelled from the container through the needle
  • said kit comprises: - a housing assembly comprising:
  • an upper housing assembly - a lower housing assembly, at least one of said upper and said lower housing assembly being adapted to receive part of the container, the container being movable, when received within said at least one of said upper and said lower housing assembly, between an initial position, in which a tip of said needle does not extend beyond a distal end of said lower housing assembly, an insertion position, distally spaced relative to said initial position and in which the tip of the needle extends beyond said distal end of said lower housing assembly, and a final position in which said needle is contained within one of said upper and said lower housing assembly, and - means for connecting said upper housing and said lower housing together.
  • said kit further comprises means for carrying at least one of said upper housing assembly and said lower housing assembly, said carrying means carrying said one of said upper housing assembly and said lower housing assembly in a predetermined orientation.
  • FIG. 1 is an exploded perspective view of an embodiment of the device of the invention
  • FIG. 2 is a cross section view of the device of figure 1 before use
  • FIG. 3 is a partial cross section view of the device of figure 1 showing the deactivation of the first retaining means
  • FIG. 4 is a cross section view of the device of figure 1 with the container in the insertion position
  • FIG. 5 is a cross section view of the device of figure 1 in the injection step, before temporization
  • - Figure 6 is a cross section view of the device of figure 1 at the end of temporization
  • - Figure 7 is a cross section view of the device of figure 1 with the container in the final position
  • FIG. 8 is a cross section view of a variant of the device of the invention.
  • FIG. 9 to 11 are cross section views of a further variant of the device of the invention, respectively during the injection step, during the temporization step, and in the final position, - Figures 12 to 16 are partial cross section views of various mechanical temporizing means,
  • FIG. 17a is a front view of the distal end of the proximal part of a plunger rod suitable for forming part of the temporizing means of the device of the invention
  • FIG. 17b is a side view of the distal end of the proximal part of the plunger rod of figure 17a
  • FIG. 17c is a cross section view in perspective of the distal part of the plunger rod of figure 17a
  • - Figures 18 to 21 are cross section views of an alternative of the device of the invention, respectively in the initial position, in the insertion position, in the end-of-injection position, and in the final position,
  • FIGS. 22 to 25 are cross section views of another variant of the device of the invention, respectively in the initial position, in the insertion position, in the end-of-injection position, and in the final position,
  • FIGS. 26 and 27 are partial side views of a tamper-evidence means suitable for the device of the invention, respectively in the pre-use condition and in the post-use condition,
  • FIGS. 28 and 29 are perspective views of means for carrying at least one of the upper housing and the lower housing of a device of the invention
  • Figures 30 to 33 are cross section views of another variant of the device of the invention, respectively in the initial position, in the insertion position, in the end-of-injection position, and in the final position.
  • Figure 1 shows an exploded perspective view of a device for automatic injection according to an embodiment of the present invention and generally designated by reference number 1.
  • the inventive device 1 comprises a housing 300 comprised of an upper housing assembly 100 and a lower housing assembly 200 that may be connected to each other by means of a snap-fit connection (110, 210) like screw-type connection, bayonet connection, or other means of connecting two parts together, in an unreleasable way or not.
  • a container 5 such as, for example, a syringe, is received in at least one of the upper and lower housing assemblies (100, 200). Preferably, the container 5 is partially received in each of the upper and lower housing assemblies (100, 200), as discussed in more detail herein.
  • the injection device comprises a container 5 which is intended to receive a product 3 that is to be injected.
  • the container 5 has a distal end 5a and an open proximal end, which is provided, on the example shown, with a flange 5b. Said flange 5b may be useful for grasping said container 5.
  • the distal end 5a of the container 5 is substantially closed and is provided with an injection needle 6.
  • This injection needle 6 provides an outlet port of said container 5 for the product 3.
  • the distal end of said container 5 is also provided with a needle shield 2 that covers and protects the needle 6 before use of the device 1.
  • the needle shield 2 also provides for a sealing means of the distal end of the container 5 before use.
  • the device 1 of figures 1 and 2 also comprises a piston 7 which is provided in the container 5 and which is movable with respect with said container 5.
  • a plunger rod 8 is coupled to said piston 7 so as to cause said piston to move with respect to said container 5, the movement of said piston 7 being intended to cause said product 3 to be expelled from said container 5 through the injection needle 6 during the injection step and thus realize injection, as will be seen on figures 4 to 6.
  • the term "coupled” refers to any permanent or temporary connection between two parts. For example, by way of illustration and not limitation, two parts may be coupled together using a screw-type connection, by mere contact with each other, or with adhesive. Other types and ways of connecting two parts will be obvious to a person skilled in the art and from the disclosure provided herein.
  • the container 5 is received within a support 21 having a global tubular shape: said support 21 is open at both ends. Said support 21 is provided at its proximal end with at least two claws 21a in which the flange 5b of the container 5 is fixed.
  • the device 1 of figures 1 and 2 further comprises a housing (9, 11) intended to receive the container 5.
  • said housing has a global tubular shape and is made of two cylinders, a proximal cylinder 9 and a distal cylinder 11 which, as shown on figure 2, are snapped to each other when the device is in use.
  • the housing (9, 11) could be made of a single piece.
  • the needle shield 2 is coupled to the housing (9, 11) and covers the needle 6 prior to use of the device 1.
  • the device 1 is provided with a deshielder 2a to which is fixed the needle shield 2.
  • a deshielder 2a is shown in greater details on figures 26 and 27.
  • the housing comprises grooves 95 for guiding the translation of said cap 90 when the cap 90 is removed together with the removal of said deshielder 2a in view of using said device 1.
  • the cap 90 follows the grooves 95 and it does not rotate.
  • the needle shield 2, which is fixed to the cap 90 neither rotates. The rotation of the tip of the needle 6 within the rubber forming the needle shield is therefore avoided and the core that could result from such a potential rotation is also avoided. The integrity and sterility of the needle 6 are therefore preserved and the administration do the product can be completed safely.
  • the container 5 is movable relative to said housing (9, 11) between an initial position, in which said needle 6 is contained within said housing (9, 11), an insertion position, distally spaced relative to said initial position and in which said needle 6 is exposed over a predetermined length, and a final position in which said needle 6 is contained within said housing (9, 11).
  • the proximal cylinder 9 of the housing is provided at its distal end with at least two flexible teeth 10 which are capable of being deflected radially and outwardly.
  • the distal cylinder 11 of the housing is provided in its distal part with at least two flexible tongues 12 which are capable of being deflected radially and outwardly.
  • I I is provided with an inner ridge 13: the distal face 13a of said inner ridge forms a bearing surface for the device 1 on the injection site 4 (see figure 4).
  • the device 1 of figures 1 and 2 further comprises a sleeve 16 having a closed proximal end 17 and an open distal end 18. Said sleeve 16 is intended to receive at least partially said support 21.
  • the proximal end 17 of the sleeve 16 comprises a vent outlet 19.
  • the vent outlet 19 may be a little hole. For instance, the diameter of said hole may range from 15 micrometer to
  • the device 1 of figures 1 and 2 further comprises a sealing cover 27 which is intended to be coupled to the head 8a of the plunger rod 8.
  • the device 1 of figures 1 and 2 also comprises a ring 14 which is intended to receive the distal part of said support 21 and to be coupled to said container 5 at least from the insertion position to the final position of said container 5.
  • the ring 14 has a proximal part and a distal part, the diameter of said proximal part being less than the diameter of said distal part, said proximal and distal parts being joined by a radial wall 15.
  • the radial wall 15 has a proximal face 15a and a distal face 15b.
  • the device 1 of figures 1 and 2 further comprises a push button 22 intended to be lodged between the proximal cylinder 9 of said housing and said sleeve 16.
  • the push button 22 has the global shape of a cylinder closed at its proximal end : the proximal end of the push button 22 forms a pushing surface 22a for the user to exert a manual pressure in view of triggering of the device 1.
  • the inner wall of the proximal part of the push button 22 is provided with an inner rim 22b.
  • the push button 22 is further provided at its distal end with at least two distal legs 23.
  • a first helicoidal spring 24 is provided between the push button 22 and the sleeve 16.
  • the distal end of the first helicoidal spring bears on the proximal face of said outer radial rim 20 of said sleeve 16
  • the proximal end of the first helicoidal spring bears on the distal face of the inner rim 22b of the push button 22.
  • a second helicoidal spring 25 is provided between said support 21 and said ring 14: as shown on figure 2, the distal end of the second helicoidal spring 25 bears on the proximal face 13b of the inner ridge 13 of the distal cylinder 11 and the proximal end of said second helicoidal spring 25 bears on the distal face 15b of said radial wall 15 of said ring 14.
  • the device 1 of figures 1 and 2 is finally provided with a deshielder 2a for removing the needle shield 2 when the user decides to realize the injection.
  • the deshielder 2a and the needle shield 2 are removably coupled with the housing (9, 11) and they act as tamper-evidence means to shield the needle 6 prior to use of the device 1 , said tamper-evidence means being able to adopt a pre-use condition and a post-use condition, said post-use condition preventing re-use of the tamper-evidence means with the device 1.
  • the functioning of the device 1 will now be explained in reference to figures 2 to 7.
  • FIG 2 is shown the device 1 before use, as provided to the user.
  • the sealing cover 27 is in an initial state wherein it tightly and sealingly closes the proximal part of said sleeve 16, thereby defining a chamber 26 having an initial volume.
  • said initial volume of said chamber 26 contains a determined amount of pressurized fluid, for example of pressurized air.
  • the fluid could be another gas or a viscous liquid, such as oil or grease.
  • the sealing cover 27 is movable between said initial state and a final state in which at least part of said pressurized fluid has escaped through the vent outlet 19.
  • the container In the position before use as shown on figure 2, the container is in its initial position. It is retained in said initial position by the engagement of said flexible teeth 10 of said proximal cylinder 9 in said outer radial rim 20 of said sleeve 16, said flexible teeth 10 and said outer radial rim 20 acting as first retaining means, under the pressure of said first helicoidal spring 24, which is in a pressurized state.
  • the needle 6 is protected by the needle shield 2 which is coupled the deshielder 2a. Accordingly, the deshielder 2a and the needle shield 2 form the tamper-evidence means which is in its pre-use condition.
  • the user decides to realize the injection, he first removes the deshielder 2a: by this operation, he also removes the needle shield 2.
  • the tamper-evidence means, formed by the deshielder 2a and the needle shield 2 is therefore in its post-use condition.
  • the removal of the needle shield 2 is completed with limited or no rotation of the needle shield 2. Potential coring caused by the tip of the needle 6 rotating in the rubber forming the needle shield 2 is therefore prevented.
  • the container 5 After deshielding, the container 5 is still retained in its initial position by the first retaining means which are in the same position as described in figure 2.
  • the user then applies the device 1 on the injection site 4 by means of the bearing surface 13a of said distal cylinder 11. He then manually actuates the push button 22 by exerting on the pushing surface 22a a distal force so as to cause said push button 22 to move distally. As shown on figure 3, during this movement, the distal legs 23 come in contact with said flexible teeth 10, causing said flexible teeth 10 to deflect radially and outwardly. By way of consequence, said flexible teeth 10 are disengaged from said outer radial rim 20 in which they were previously engaged. The first helicoidal spring 24 is therefore free to return to a normal state and it extends distally, drawing with him the sleeve 16.
  • the sleeve 16 being coupled to said plunger rod 8 by means of the sealing cover 27 which is fixed onto the head 8a of the plunger rod 8, the plunger rod 8 is drawn distally by the sleeve 16.
  • the distal end of the plunger rod 8 being threaded within the piston 7, the plunger rod 8 is coupled to said container 5, at least from the initial position to the insertion position of the container, by means of the friction force exerted by the outer walls of said piston 7 onto the inner walls of said container 5.
  • the container 5 is also drawn distally causing the needle 6 to penetrate the injection site 4 until the distal end of said support 21 abuts on the proximal face 13b of the inner ridge 13 of said distal cylinder 11 , as shown on figure 4.
  • the container 5 is therefore in the insertion position and the injection of the product 3 can start.
  • the injection is automatically driven by means of the first helicoidal spring 24 which continues to extend distally towards its normal state.
  • the force of the first helicoidal spring 24 overcomes the stiction force and the piston 7 is caused to move distally within said container 5, thereby expelling said product 3 through said injection needle 6.
  • the force of said first helicoidal spring 24 overcomes the friction force of the sealing cover 27 against the inner walls of said sleeve 16 and said sleeve continues to move distally, causing part of the pressurized fluid present in said chamber 26 to escape via the vent outlet 19, as shown on figure 5.
  • the time for the sealing cover 27 to move from its initial state to its final state allows the totality of the liquid to be expelled through the injection needle 6.
  • the sleeve 16 continues to move distally, under the force exerted by said first helicoidal spring 24, until the sealing cover 27 comes in contact with the proximal end of said sleeve 16 and substantially all the pressurized fluid present in the chamber 26 has escaped via the vent outlet 19.
  • the outer radial rim 20 comes in contact with said flexible tongues 12 which are then caused to deflect radially and outwardly, as shown on figure 6.
  • the radial wall 15 is therefore disengaged from said flexible tongues 12 and the second helicoidal spring 25 is free to move proximally.
  • the retraction of the needle within the housing is an indication for a user that substantially all of the product contained within the container has been caused to pass through the outlet port of the injection needle 6.
  • the needle 6 is contained within said housing (9, 11) and the device 1 is therefore ready to be disposed of, without any risk of accidental needlestick injury.
  • the friction force of the sealing cover 27 against the inner walls of said sleeve 16 is such as allowing said sealing cover 27 to start moving from its initial state as soon as the injection begins.
  • the force of the first helicoidal spring 24 is reduced by adding a third spring for moving said sealing cover 27 from its initial state to its final state.
  • a third spring for moving said sealing cover 27 allows the reducing of the force with which the support 21 or the container 5 touches the inner ridge 13 or the injection site 4, especially the skin, and brings some comfort to the user.
  • FIG 8 is shown a variant of the device 1 of figures 1 to 7, in which the sleeve forming the chamber is confounded with the push button.
  • the references pertaining with the same elements as in figures 1 to 7 have been retained.
  • the deactivating means and the chamber are provided as a sleeve 30 which is closed at its proximal end.
  • Said proximal end forms a pushing surface 30a for the user to exert a manual and distal pressure when he wishes to activate the device 1.
  • the proximal end comprises a vent outlet 29b.
  • a sealing cover 29a is provided on the head of a plunger rod 8.
  • the sleeve 30 is provided with at least an outer projection 31 and said housing 9 is provided with a stop 32.
  • said outer projection 31 is in abutment against said stop 32, said outer projection 31 and said stop 32 forming first retaining means of said container 5 in the initial position.
  • the user applies the device 1 on the injection site and he pushes distally on pushing surface 30a causing said sleeve 30 to move distally.
  • the manual pressure exerted on the sleeve 30 by the user overcomes said stop 32 and the first helicoidal spring 24 is then free to move distally.
  • the first helicoidal spring 24 pushes on the outer radial rim 20 of said sleeve 30, thereby realising the insertion of the needle 6, the injection and the temporization as seen for the device 1 of figures 1 to 7.
  • FIG. 9 is shown another variant of the device 1 of the invention, in which the plunger rod is provided in two parts, a proximal part and a distal part, that separate when said piston comes into contact with the distal end of said container.
  • the references pertaining with the same elements as in figures 1 to 7 have been retained.
  • a device 1 according to the invention comprising a plunger rod 40 provided in two parts, a proximal part 41 and a distal part 42.
  • the proximal part 41 of the plunger rod 40 is provided at its proximal end with a head 49 and at its distal end with a radial projection 44.
  • the distal part 42 of the plunger rod comprises a cylinder, the inner walls of which are coated with a rubbery material 43.
  • the housing 9 is provided on its inner wall with at least two radially flexible legs 46.
  • the device 1 further comprises a ring 48, said ring 48 being coupled to said container 5 when said container moves from its insertion position to its final position.
  • Said ring 48 comprises an abutment surface 47.
  • the device 1 is in the injection position, said container 5 being in the insertion position.
  • the first helicoidal spring 24 realizes the injection automatically by pushing distally the head 49 of the plunger rod 40. In this position, the force exerted by the first helicoidal spring 24 on the plunger rod 40 is not great enough to separate said plunger rod in two parts.
  • the piston 7 is caused to move distally, thereby expelling the product3 through the injection needle 6.
  • the head 49 comes in contact with the flexible legs 46 of the housing 9 and cause them to be deflected radially.
  • the abutment surface 47 is thereby disengaged from said flexible legs 46 and the second helicoidal spring 25 is free to return to its normal state and to extend in the proximal direction, as shown on figure 11.
  • FIG. 12 to 17c are shown alternative temporizing means in the form of a plunger rod 40 provided in two parts, a proximal part 41 and a distal part 42.
  • plunger rods 40 similar to that of figures 9 to 11, in which the rubbery material has been replaced by a compressible material (50, 51): on figure 16, the compressible material is a spring 51.
  • the speed of the proximal part 41 of the plunger rod 40 is reduced and some time is therefore allowed for substantially all of the product to be expelled 3 before the head of the plunger rod cooperates with the second retaining means so as to cause the retraction of the container.
  • a plunger rod 40 in two parts, wherein the diameter of the cylinder 42, which forms the distal part of the plunger rod, decreases towards the bottom of said cylinder.
  • the distal end of the proximal part 41 of said plunger rod 40 is provided with flexible tongues 52 that rub against the inner walls of said cylinder, causing the proximal part 41 to be slowed down when it moves distally.
  • a plunger rod 40 for which the inner walls of said cylinder 42 are provided with a thread 55 which cooperates with a screw 56 provided at the distal end of said proximal part 41 of said plunger rod, thereby reducing the speed of said proximal part 41 of said plunger rod, as said proximal part of said plunger rod moves distally.
  • a plunger rod 40 for which the inner walls of said cylinder 42 are provided with longitudinal flexible legs 53 that come in contact with a radial projection 54 provided at the distal end of said proximal part 41 of said plunger rod, thereby reducing the speed of said proximal part 41 of said plunger rod, as said proximal part of said plunger rod moves distally.
  • FIG. 17a to 17c On figures 17a to 17c is shown a plunger rod for which said cylinder walls are provided with a number of steps 57 and the distal end of said proximal part of said plunger rod is provided with a number of radial flaps 58, the number of radial flaps that interact with said steps increasing as said proximal part of said plunger rod moves distally.
  • the device 1 of figures 18-21 comprises a chamber 59 partly defined by the inner part 61 of the container situated proximally to the piston 7.
  • the rest of the chamber 59 is defined by the walls of the housing 68 receiving the container 5.
  • a sealing cover 60 joins the proximal end 5b of said inner part 61 to the housing 68 through a friction force of absolute value F.
  • the chamber 59 At its proximal end, the chamber 59 comprises a vent outlet 63.
  • the chamber 59 also comprises a recipient 65, preferably made of rigid walls.
  • this recipient 65 In the initial position of the container, as shown on figure 18, this recipient 65 is sealingly closed and is filled with a pressurized fluid 64.
  • the device of figures 18-21 further comprises a puncturing button
  • the size of the opening 67 is much larger than the size of the vent outlet 63.
  • the device 1 of figures 18-21 comprises a sleeve 69 received within said housing 68 and receiving said container 5.
  • the sleeve 69 comprises in its distal area an inner radial rim 70.
  • a helical spring 62 is placed between said container 5 and said sleeve 69, the proximal end of said spring 62 bearing on the distal face of said proximal end of said container 5 and the distal end of said spring bearing on the proximal face of said inner radial rim 70 of said sleeve 69.
  • the absolute value of the return force exerted by the spring 62 on said container 5 when said spring is at least in a partly compressed state is called Pe.
  • the device 1 is provided to the user in its initial position shown on figure 18.
  • the needle 6 is protected by a needle shield 2 and a deshielder 2a.
  • the recipient 65 is filled with the pressurized fluid 64.
  • the user desires to proceed with the administration of the product 3, he removes the deshielder 2a and the needle shield 2, applies the device 1 on the injection site 4 and exerts a manual force on the puncturing button 66.
  • the puncturing button 66 penetrates a wall of the recipient 65 and creates an opening 67 as shown on figure 19.
  • the pressurized fluid 64 is then allowed to escape the recipient 65 via the opening 67 and begins to fill the chamber 59.
  • the pressurized fluid 64 spreads into the chamber 59, it pushes on the sealing cover 60 and therefore on the container 5 which is caused to move distally.
  • the needle 6 penetrates the injection site and the device 1 is in the insertion position.
  • the product 3 is injected in the injection site 4 via the needle 6 until the piston 7 is proximate to the distal end of the container 5, as shown on figure 20.
  • Pc is greater than (Pe + F). As the pressurized fluid 64. escapes through the vent outlet 63, Pc decreases.
  • the retaining means are formed by Pc being greater than (Pe + F).
  • the return of the spring 62 to its expanded state is subject to the flowing of the fluid 64 outside the chamber 59 via the vent outlet 63.
  • FIG. 22-25 is shown an alternative of the embodiment of figures 18-21.
  • the device 1 of figures 22-25 comprises a chamber 79 partly defined by the inner part 71 of the container 5 situated proximally to the piston
  • the rest of the chamber 79 is defined by the walls of the housing 72 receiving the container 5 and by the head 73 of a piston rod 74.
  • the distal end 77 of the piston rod 74 is not fixed to the piston 7.
  • a first sealing cover 75 joins the proximal end 5b of said inner part 71 to the housing 72.
  • a second sealing cover 76 joins the head 73 of the piston rod 74 to the housing 72 and therefore seals the chamber 79.
  • the two sealing covers (75, 76) are porous sealing cover. In consequence, they both form an outlet vent for any pressurized fluid comprised in the chamber 79.
  • the two sealing covers (75, 76) present altogether a friction force against the wall of the housing 72 of absolute value F.
  • the device 1 of figures 22-25 comprises a sleeve 78 received within said housing 72 and receiving said container 5.
  • the sleeve 78 comprises in its distal area an inner radial rim 80.
  • a helical spring 81 is placed between said container 5 and said sleeve 78, the proximal end of said spring 81 bearing on the distal face of said proximal end of said container 5 and the distal end of said spring bearing on the proximal face of said inner radial rim 80 of said sleeve 78.
  • the absolute value of the return force exerted by the spring 81 on said container 5 when said spring is at least in a partly compressed state is called Pe.
  • the device 1 of figures 22-25 further comprises a stop 82 provided on the inner wall of said housing 72.
  • the device 1 also comprises a push button 83 having two distal legs 84.
  • the head 73 of the piston rod 74 is provided with two proximal flexible tongues 85.
  • the proximal end of the housing 72 is provided with two abutment surfaces 86.
  • a helical spring 87 is provided within the push button 83 and the proximal part of the head 73 of the piston rod 74.
  • the proximal end of the spring 87 bears on the distal face of the push button 83, and the distal end of the spring 87 bears on the proximal face of the proximal part of the head 73 of the piston rod 74.
  • the absolute value of the return force exerted by the spring 87 on said piston rod 74 when said spring is at least in a partly compressed state is called Pi.
  • the needle 6 is protected by a needle shield 2 and a deshielder 2a.
  • the proximal tongues 85 of the head 73 of the piston rod 74 are engaged in the abutment surfaces 86 of the housing 72.
  • the spring 87 is in a compressed state.
  • the user desires to proceed with the administration of the product 3, he removes the deshielder 2a and the needle shield 2, applies the device 1 on the injection site 4 and exerts a manual force on the pushing button 83.
  • the push button 83 therefore moves distally and its distal legs 84 come in contact with the flexible tongues 85 of the housing 72. Under the pressure of the distal legs 84, the flexible tongues 85 deflect radially and become disengaged from the abutment surfaces 86. The spring 87 is then free to return to its expanded state and it pushes the piston rod 74 in the distal direction.
  • the volume defining the chamber 79 decreases, as shown on figure 24.
  • the fluid for example the gas or the air
  • the fluid present within said chamber 79 becomes pressurized.
  • the distal movement of the piston rod 74 is stopped by the stop 82 provided on the inner wall of said housing 72.
  • the pressurized fluid, referenced 88 on figure 24 fills therefore the space situated between the piston 7 and the distal end 77 of the piston rod 74, therefore maintaining the piston 7 against the distal end of the container 5 and allowing extra time for the injection to be totally completed.
  • the pressure of the pressurized fluid 88 is called Pc.
  • the retaining means are formed by (Pc +
  • FIG. 26 and 27 there is shown partial views of a deshielder 2a suitable as a tamper-evidence means for a device of the invention.
  • the deshielder 2a is made of a cap 90 and a ring 91 connected to each other by breakable bridges 92.
  • the deshielder 2a is fixed on the housing 93 of a device according to the invention.
  • the cap 90 and the ring 91 are made of a single piece, for example by moulding injection, and are connected to each other by means of the breakable bridges 92
  • the housing 93 is provided with stops 94 that prevent a user from breaking the bridges 92 by applying a proximal force on the cap 90.
  • a user When a user is ready to use the device of the invention, he removes the deshielder 2a by pulling distally on the cap 90 so as to remove it from the housing 93, thereby breaking the breakable bridges 92.
  • the housing 93 is provided with grooves 95 that guide the translation of the cap 90 as it is removed.
  • the deshielder and the needle shield (not shown) which is within the cap 90, are removed with limited or no rotation of the needle (not shown). Coring caused by the tip of the needle rotating in the rubber forming the needle shield is therefore prevented.
  • the tamper-evidence means formed by the deshielder 2a is in its post-use condition. Any user, provided with the device with the deshielder 2a in this condition can immediately notice, thanks to the broken bridges 92, that the device has been tampered.
  • the post-use condition of the deshielder proves an indication that the tamper-evidence means has been removed from the device.
  • a tray 400 for carrying upper housing assemblies 100 in a predetermined direction On figure 28 is shown a tray 400 for carrying upper housing assemblies 100 in a predetermined direction.
  • the carrying means 400 of figure 28 can especially carry a plurality of upper housings 100, all disposed in the same direction.
  • Such a tray comprises a plurality of holes 402 intended to receive the upper housing assemblies 100.
  • Such a tray 400 is useful for transporting and/or handling upper housings of a device of the invention during all the various steps of manufacturing, filling, packaging, etc...
  • FIG 29 On figure 29 is shown a tray 401 similar to the tray 400 of figure 28, the tray 401 carrying, in the example shown a plurality of lower housing assemblies 200 of a device of the invention, in a predetermined orientation.
  • the device 1 of figures 30-33 comprises a chamber 96 partly defined by the inner part 71 of the container 5 situated proximally to the piston
  • the rest of the chamber 96 is defined by the walls of the housing 72 receiving the container 5 and by the head 73 of a piston rod 74.
  • a first sealing cover 97 joins the proximal end 5b of said inner part 71 to the housing 72.
  • a second sealing cover 98 joins the head 73 of the piston rod 74 to the housing 72 and therefore seals the chamber 96.
  • the two sealing covers (97, 98) are porous sealing cover. In consequence, they both form an outlet vent for any pressurized fluid comprised in the chamber 96.
  • the two sealing covers (97, 98) present altogether a friction force against the wall of the housing 72 of absolute value F.
  • the device 1 of figures 30-33 comprises a sleeve 102 received within said housing 72 and receiving said container 5.
  • the sleeve 102 comprises in its distal area an inner radial rim 103 and at its proximal end a flexible tongue 104 provided with an abutment surface 105.
  • a helical spring 106 is placed between said container 5 and said sleeve 102, the proximal end of said spring 106 bearing on the distal face of said abutment surface 105 by the intermediary of a ring 107 and the distal end of said spring 106 bearing on the proximal face of said inner radial rim 103 of said sleeve 102.
  • the device 1 of figures 30-33 further comprises a push button 83 having two distal legs 84.
  • the head 73 of the piston rod 74 is provided with two proximal flexible tongues 85.
  • the proximal end of the housing 72 is provided with two abutment surfaces 86.
  • a helical spring 87 is provided within the push button 83 and the proximal part of the head 73 of the piston rod 74.
  • the proximal end of the spring 87 bears on the distal face of the push button 83, and the distal end of the spring 87 bears on the proximal face of the proximal part of the head 73 of the piston rod 74.
  • the device 1 is provided to the user in its initial position shown on figure 30.
  • the needle 6 is protected by a needle shield 2 and a deshielder 2a.
  • the proximal tongues 85 of the head 73 of the piston rod 74 are engaged in the abutment surfaces 86 of the housing 72.
  • the spring 87 is in a compressed state.
  • the push button 83 therefore moves distally and its distal legs 84 come in contact with the flexible tongues 85 of the housing 72. Under the pressure of the distal legs 84, the flexible tongues 85 deflect radially and become disengaged from the abutment surfaces 86. The spring 87 is then free to return to its expanded state and it pushes the piston rod 74 in the distal direction.
  • the friction F of the sealing covers (97, 98) being less than the friction force of the piston 7 against the inner wall of the container 5, said container 5 is drawn in the distal direction, thereby realising the insertion of the needle 6 in the injection site 4, as shown on figure 31.
  • the volume defining the chamber 96 decreases.
  • the fluid for example the gas or the air
  • This fluid fills the space situated between the piston and the distal end 77 of the piston rod 74. Because of this space, when the piston 7 comes proximate to the distal end of the contained 5, the head 73 of the piston rod 74 is not in contact with the sealing cover 97.
  • the porosity of the sealing covers (97, 98) allows said sealing covers to act as a vent outlet and some of the pressurized fluid present in the chamber 96 is allowed to escape said chamber 96 slowly, giving sufficient time for substantially all of the product 3 to be ejected.
  • the piston rod 74 is allowed to move slowly distally, and the head 73 of the piston rod 74 comes in contact with the valve 99 of the sealing cover 97.
  • the valve 99 is pushed distally and comes in contact with the flexible tongue 104 which deflects radially, freeing the ring 107 and the spring 106.
  • the freed spring 106 begins to moves proximally but it is slowed down by the force of the pressurized fluid present in the chamber 96. With the proximal movement of the spring 106, the ring 107 comes in contact with the valve 99 and opens it.
  • the pressurized fluid still present in the chamber 96 is then allowed to escape via the open valve 99 and the spring 106 returns rapidly to its expanded state.
  • the device of the invention is very easy to use and very safe. It allows automatic injection of a product to be performed by a patient without any risk of needlestick injury, before, during and after use. In particular, it allows the retraction of the needle within the device only once substantially all of the product has been injected. Injections of improper doses of product are therefore prevented.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection (1) qui comprend : un contenant (5) conçu pour recevoir un produit et qui est muni d'une aiguille d'injection (6); un logement (9, 11) conçu pour recevoir ledit contenant, le contenant pouvant être déplacé par rapport audit logement entre une position initiale, une position d'insertion, et une position finale; des moyens de retenue (12, 15) qui permettent de maintenir ledit contenant dans ladite position d'insertion; des moyens de désactivation (20) qui permettent de libérer lesdits moyens de retenue. Ledit dispositif est caractérisé en ce qu'il comprend : des moyens de temporisation (19, 26, 27) qui permettent de commander la libération desdits moyens de retenue jusqu'à ce que la totalité du produit contenu dans ledit contenant ait traversé ladite aiguille d'injection avant que le contenant ne passe en position finale; et une protection (2) d'aiguille raccordée audit logement (9, 11), le retrait de ladite protection étant effectué avec une rotation limitée ou nulle. L'invention concerne également un kit comprenant ledit dispositif.
PCT/IB2007/003451 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation WO2008029280A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP17179236.9A EP3257537B1 (fr) 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation
EP07848874.9A EP2076299B1 (fr) 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation
US12/440,145 US7976514B2 (en) 2006-09-06 2007-09-05 Automatic injection device with temporizing means
JP2009527225A JP5202529B2 (ja) 2006-09-06 2007-09-05 一時しのぎ手段を持つ自動注入器具
EP17179230.2A EP3254715B9 (fr) 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation
ES07848874.9T ES2643939T3 (es) 2006-09-06 2007-09-05 Dispositivo de inyección automática con medios de temporización
EP17179232.8A EP3254716B1 (fr) 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation
US13/152,336 US8435215B2 (en) 2006-09-06 2011-06-03 Automatic injection device with temporizing means
US13/864,881 US9486582B2 (en) 2006-09-06 2013-04-17 Automatic injection device with temporizing means

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR06/07806 2006-09-06
FR0607806A FR2905273B1 (fr) 2006-09-06 2006-09-06 Dispositif d'injection automatique avec moyen de temporisation.
FR0611200A FR2905274B1 (fr) 2006-09-06 2006-12-21 Kit d'injection automatique

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/440,145 A-371-Of-International US7976514B2 (en) 2006-09-06 2007-09-05 Automatic injection device with temporizing means
US13/152,336 Continuation US8435215B2 (en) 2006-09-06 2011-06-03 Automatic injection device with temporizing means

Publications (2)

Publication Number Publication Date
WO2008029280A2 true WO2008029280A2 (fr) 2008-03-13
WO2008029280A3 WO2008029280A3 (fr) 2008-11-13

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PCT/IB2007/003451 WO2008029280A2 (fr) 2006-09-06 2007-09-05 Dispositif d'injection automatique équipé de moyens de temporisation

Country Status (5)

Country Link
US (3) US7976514B2 (fr)
EP (4) EP3254716B1 (fr)
JP (1) JP5202529B2 (fr)
FR (2) FR2905273B1 (fr)
WO (1) WO2008029280A2 (fr)

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EP2076299A2 (fr) 2009-07-08
EP3254716B1 (fr) 2023-06-07
EP2076299B1 (fr) 2017-07-19
FR2905274A1 (fr) 2008-03-07
US20100094214A1 (en) 2010-04-15
JP2010502340A (ja) 2010-01-28
EP3254715B1 (fr) 2021-08-04
EP3257537B1 (fr) 2021-07-28
US8435215B2 (en) 2013-05-07
FR2905273A1 (fr) 2008-03-07
EP3254716A1 (fr) 2017-12-13
FR2905274B1 (fr) 2013-11-15
US9486582B2 (en) 2016-11-08
EP3254715A1 (fr) 2017-12-13
EP3257537A1 (fr) 2017-12-20
EP3254715B9 (fr) 2021-12-15
US7976514B2 (en) 2011-07-12
WO2008029280A3 (fr) 2008-11-13
US20110275992A1 (en) 2011-11-10

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