WO2007065594A3 - Ungesättigte fettsäuren als thrombin-inhibitoren - Google Patents

Ungesättigte fettsäuren als thrombin-inhibitoren Download PDF

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Publication number
WO2007065594A3
WO2007065594A3 PCT/EP2006/011497 EP2006011497W WO2007065594A3 WO 2007065594 A3 WO2007065594 A3 WO 2007065594A3 EP 2006011497 W EP2006011497 W EP 2006011497W WO 2007065594 A3 WO2007065594 A3 WO 2007065594A3
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WO
WIPO (PCT)
Prior art keywords
fatty acid
unsaturated fatty
fatty acids
carbon atoms
double bonds
Prior art date
Application number
PCT/EP2006/011497
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English (en)
French (fr)
Other versions
WO2007065594A2 (de
Inventor
Hans-Rainer Hoffmann
Original Assignee
Lohmann Therapie Syst Lts
Hans-Rainer Hoffmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts, Hans-Rainer Hoffmann filed Critical Lohmann Therapie Syst Lts
Priority to US12/084,438 priority Critical patent/US20090234007A1/en
Priority to EP06829197A priority patent/EP1957062A2/de
Priority to JP2008543700A priority patent/JP2009518332A/ja
Publication of WO2007065594A2 publication Critical patent/WO2007065594A2/de
Publication of WO2007065594A3 publication Critical patent/WO2007065594A3/de
Priority to US13/134,938 priority patent/US20110268800A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Die vorliegende Erfindung betrifft die Verwendung mindestens einer ungesättigten Fettsäuren mit einer Kettenlänge von 18 oder 20 Kohlenstoffatomen und pflanzlichen Drogen, die diese ungesättigten Fettsäure als frei Fettsäuren oder als Fettsäurerest eines Triglycerids enthalten, wobei die Fettsäure mit einer Kettenlänge von 18 Kohlenstoff-Atomen 1 bis 3 Doppelbindungen und die Fettsäuren mit einer Kettenlänge von 20 Kohlenstoff-Atomen 1 bis 4 Doppelbindungen aufweist, die Doppelbindung oder eine der Doppelbindungen sich an Position 9 oder 11 der Kohlenstoff kette befindet, und die ungesättigte Fettsäure in der all-cis Konfiguration vorliegt, zur Prophylaxe und/oder Behandlung von oder zur Herstellung eines Mittels zur Prophylaxe und/oder Behandlung von Thrombosen und thromboembolischen Erkrankungen, sowie die entsprechenden Mittel.
PCT/EP2006/011497 2005-12-06 2006-11-30 Ungesättigte fettsäuren als thrombin-inhibitoren WO2007065594A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/084,438 US20090234007A1 (en) 2005-12-06 2006-11-30 Unsaturated Fatty Acids as Thrombin Inhibitors
EP06829197A EP1957062A2 (de) 2005-12-06 2006-11-30 Ungesättigte fettsäuren als thrombin-inhibitoren
JP2008543700A JP2009518332A (ja) 2005-12-06 2006-11-30 トロンビン阻害剤としての不飽和脂肪酸
US13/134,938 US20110268800A1 (en) 2005-12-06 2011-06-21 Unsaturated fatty acids as thrombin inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005058369.5 2005-12-06
DE102005058369A DE102005058369A1 (de) 2005-12-06 2005-12-06 Ungesättigte Fettsäuren als Thrombin-Inhibitoren

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/134,938 Division US20110268800A1 (en) 2005-12-06 2011-06-21 Unsaturated fatty acids as thrombin inhibitors

Publications (2)

Publication Number Publication Date
WO2007065594A2 WO2007065594A2 (de) 2007-06-14
WO2007065594A3 true WO2007065594A3 (de) 2007-08-16

Family

ID=37946254

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/011497 WO2007065594A2 (de) 2005-12-06 2006-11-30 Ungesättigte fettsäuren als thrombin-inhibitoren

Country Status (5)

Country Link
US (2) US20090234007A1 (de)
EP (1) EP1957062A2 (de)
JP (1) JP2009518332A (de)
DE (1) DE102005058369A1 (de)
WO (1) WO2007065594A2 (de)

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US11857588B2 (en) 2005-04-05 2024-01-02 Membrane Protective Technologies, Inc. Reproductive cell maintenance system
US9919014B2 (en) * 2005-04-05 2018-03-20 Membrane Protective Technologies, Inc. Reproductive cell maintenance system
US8343753B2 (en) 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
KR101522457B1 (ko) * 2013-06-21 2015-05-21 안동대학교 산학협력단 비타민나무 잎 추출물을 유효성분으로 함유하는 혈전증 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
JP6934903B2 (ja) * 2019-03-12 2021-09-15 オルガノフードテック株式会社 血栓溶解剤、血栓溶解作用促進剤

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JP2009518332A (ja) 2009-05-07
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WO2007065594A2 (de) 2007-06-14
DE102005058369A1 (de) 2007-06-14

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