WO2007022502A3 - Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase - Google Patents

Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase Download PDF

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Publication number
WO2007022502A3
WO2007022502A3 PCT/US2006/032579 US2006032579W WO2007022502A3 WO 2007022502 A3 WO2007022502 A3 WO 2007022502A3 US 2006032579 W US2006032579 W US 2006032579W WO 2007022502 A3 WO2007022502 A3 WO 2007022502A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compounds
bridged
inhibitors
gamma secretase
Prior art date
Application number
PCT/US2006/032579
Other languages
English (en)
Other versions
WO2007022502A2 (fr
Inventor
Simeon Bowers
Albert W Garofalo
Roy K Hom
Andrei W Konradi
Matthew N Mattson
Martin L Neitzel
Chris M Semko
Anh P Truong
Jing Wu
Ying-Zi Xu
Original Assignee
Elan Pharm Inc
Simeon Bowers
Albert W Garofalo
Roy K Hom
Andrei W Konradi
Matthew N Mattson
Martin L Neitzel
Chris M Semko
Anh P Truong
Jing Wu
Ying-Zi Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Simeon Bowers, Albert W Garofalo, Roy K Hom, Andrei W Konradi, Matthew N Mattson, Martin L Neitzel, Chris M Semko, Anh P Truong, Jing Wu, Ying-Zi Xu filed Critical Elan Pharm Inc
Priority to JP2008527207A priority Critical patent/JP2009506988A/ja
Priority to AU2006279312A priority patent/AU2006279312A1/en
Priority to EP06813596A priority patent/EP1916985A4/fr
Priority to CA002632670A priority patent/CA2632670A1/fr
Publication of WO2007022502A2 publication Critical patent/WO2007022502A2/fr
Publication of WO2007022502A3 publication Critical patent/WO2007022502A3/fr
Priority to IL190970A priority patent/IL190970A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention se rapporte à des composés sulfonamides N-cycliques et à leurs sels, qui sont représentés par la formule (I). Dans ladite formule, A est tel que défini dans le descriptif de l'invention, et R1 et R2 se combinent pour former un système cyclique [3.3.1] ou [3.2.1], l'azote étant relié aux deux carbones têtes de pont, et les systèmes cycliques [3.3.1] ou [3.2.1] étant éventuellement fusionnés avec un cycle hétéroaryle ou hétérocycloalkyle. Les composés représentés par la formule (I) sont utiles pour traiter ou prévenir des troubles cognitifs tels que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques contenant des composés représentés par la formule (I), des méthodes destinées à traiter des troubles cognitifs tels que la maladie d'Alzheimer, et des intermédiaires utiles pour préparer les composés représentés par la formule (I).
PCT/US2006/032579 2005-08-19 2006-08-18 Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase WO2007022502A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008527207A JP2009506988A (ja) 2005-08-19 2006-08-18 ガンマセクレターゼの架橋ｎ−環状スルホンアミド阻害剤
AU2006279312A AU2006279312A1 (en) 2005-08-19 2006-08-18 Bridged N-cyclic sulfonamido inhibitors of gamma secretase
EP06813596A EP1916985A4 (fr) 2005-08-19 2006-08-18 Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase
CA002632670A CA2632670A1 (fr) 2005-08-19 2006-08-18 Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase
IL190970A IL190970A0 (en) 2005-08-19 2008-04-17 Bridged n-cyclic sulfonamido inhibitors of gamma secretase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70996105P 2005-08-19 2005-08-19
US60/709,961 2005-08-19

Publications (2)

Publication Number Publication Date
WO2007022502A2 WO2007022502A2 (fr) 2007-02-22
WO2007022502A3 true WO2007022502A3 (fr) 2007-10-04

Family

ID=37758487

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/032261 WO2007024651A2 (fr) 2005-08-19 2006-08-18 Inhibiteurs sulfonamido n-bicycliques pontes de gamma-secretase
PCT/US2006/032579 WO2007022502A2 (fr) 2005-08-19 2006-08-18 Inhibiteurs sulfonamides n-cycliques pontes de la gamma secretase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032261 WO2007024651A2 (fr) 2005-08-19 2006-08-18 Inhibiteurs sulfonamido n-bicycliques pontes de gamma-secretase

Country Status (16)

Country Link
US (4) US7345056B2 (fr)
EP (2) EP1915371A4 (fr)
JP (2) JP2009506988A (fr)
KR (1) KR20080042135A (fr)
CN (2) CN101426860A (fr)
AR (1) AR056470A1 (fr)
AU (2) AU2006279312A1 (fr)
BR (1) BRPI0614944A2 (fr)
CA (2) CA2632670A1 (fr)
EC (1) ECSP088293A (fr)
IL (2) IL189217A0 (fr)
MX (1) MX2008002234A (fr)
RU (2) RU2008110488A (fr)
TW (1) TW200740806A (fr)
WO (2) WO2007024651A2 (fr)
ZA (1) ZA200803521B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115137B2 (en) 2008-01-25 2015-08-25 Medivation Technologies, Inc. 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof
US9580425B2 (en) 2009-09-23 2017-02-28 Medivation Technologies, Inc. Pyrido[3,4-b] indoles and methods of use

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
EP1915371A4 (fr) * 2005-08-19 2010-09-15 Elan Pharm Inc Inhibiteurs sulfonamido n-bicycliques pontes de gamma-secretase
TW200736255A (en) 2005-12-01 2007-10-01 Elan Pharm Inc 5-(Substituted)-pyrazolopiperidines
BRPI0812014A2 (pt) * 2007-05-25 2014-11-18 Elan Pharm Inc Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos
US8604195B2 (en) * 2007-08-15 2013-12-10 Merck Sharp & Dohme Corp. Substituted bicyclic piperidinyl- and piperazinyl-sulfonamides useful to inhibit 11β-hydroxysteroid dehydrogenase type-1
US8546381B2 (en) 2008-03-24 2013-10-01 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
EA201170421A1 (ru) * 2008-09-05 2012-01-30 Элан Фармасьютикалз, Инк. N-сульфонамидопиразолильные полициклические соединения
WO2011038164A1 (fr) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Composés hétérocycliques pontés et leurs méthodes d'utilisation
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
MX2013002208A (es) 2010-08-23 2013-05-30 Amgen Inc Derivados de sulfonilpiperazina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes.
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
WO2013019901A2 (fr) * 2011-08-02 2013-02-07 Buck Institute For Research On Aging Esters de tropinol et composés apparentés destinés à favoriser le traitement normal de l'app
EP2690102A1 (fr) 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Aza-amides bicycliques pour le traitement de troubles psychiatriques
JP6556255B2 (ja) * 2015-05-25 2019-08-07 華為技術有限公司Ｈｕａｗｅｉ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｃｏ．，Ｌｔｄ． フォトクロミックレンズモジュール、カメラ、及び端末装置

Citations (3)

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US5998410A (en) * 1995-09-27 1999-12-07 Ono Pharmaceuticals Co., Ltd. Sulfonamide derivatives
US20040229902A1 (en) * 2003-05-13 2004-11-18 Schering Corporation Bridged N-arylsulfonylpiperidines as gamma-secretase inhibitors

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CA2585172C (fr) * 2004-10-29 2014-08-12 Kalypsys, Inc. Composes bicycliques a substitution sulfonyle, modulateurs des ppars
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
EP1915371A4 (fr) * 2005-08-19 2010-09-15 Elan Pharm Inc Inhibiteurs sulfonamido n-bicycliques pontes de gamma-secretase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
US5998410A (en) * 1995-09-27 1999-12-07 Ono Pharmaceuticals Co., Ltd. Sulfonamide derivatives
US20040229902A1 (en) * 2003-05-13 2004-11-18 Schering Corporation Bridged N-arylsulfonylpiperidines as gamma-secretase inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115137B2 (en) 2008-01-25 2015-08-25 Medivation Technologies, Inc. 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof
US9580425B2 (en) 2009-09-23 2017-02-28 Medivation Technologies, Inc. Pyrido[3,4-b] indoles and methods of use

Also Published As

Publication number Publication date
ZA200803521B (en) 2009-12-30
RU2008110488A (ru) 2009-09-27
MX2008002234A (es) 2008-03-27
CA2632670A1 (fr) 2007-02-22
TW200740806A (en) 2007-11-01
AR056470A1 (es) 2007-10-10
US20110178119A1 (en) 2011-07-21
IL190970A0 (en) 2009-02-11
EP1916985A4 (fr) 2010-06-09
BRPI0614944A2 (pt) 2011-04-26
EP1915371A4 (fr) 2010-09-15
ECSP088293A (es) 2008-04-28
US20070049612A1 (en) 2007-03-01
AU2006279312A1 (en) 2007-02-22
IL189217A0 (en) 2008-06-05
JP2009504773A (ja) 2009-02-05
AU2006283567A1 (en) 2007-03-01
WO2007024651A2 (fr) 2007-03-01
EP1916985A2 (fr) 2008-05-07
RU2008133306A (ru) 2010-02-20
US7754712B2 (en) 2010-07-13
US20110003802A1 (en) 2011-01-06
CN101426860A (zh) 2009-05-06
RU2422443C2 (ru) 2011-06-27
US20080090817A1 (en) 2008-04-17
KR20080042135A (ko) 2008-05-14
EP1915371A2 (fr) 2008-04-30
CA2618087A1 (fr) 2007-03-01
US7345056B2 (en) 2008-03-18
WO2007024651A3 (fr) 2007-07-12
JP2009506988A (ja) 2009-02-19
WO2007022502A2 (fr) 2007-02-22
CN101304997A (zh) 2008-11-12

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Free format text: PEDIDO RETIRADO EM RELACAO AO BRASIL POR TER SIDO INTEMPESTIVO, JA QUE A SOLICITACAO DE RESTABELECIMENTO DE DIREITO FOI NEGADA CONFORME PARECER DISPONIVEL NO E-PARECER E NAO TENDO O DEPOSITANTE ENTRADO COM NENHUMA MANIFESTACAO CONTRA A DECISAO.