ZA200803521B - Bridged N-cyclic sulfonamido inhibitors of gamma secretase - Google Patents

Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Info

Publication number
ZA200803521B
ZA200803521B ZA200803521A ZA200803521A ZA200803521B ZA 200803521 B ZA200803521 B ZA 200803521B ZA 200803521 A ZA200803521 A ZA 200803521A ZA 200803521 A ZA200803521 A ZA 200803521A ZA 200803521 B ZA200803521 B ZA 200803521B
Authority
ZA
South Africa
Prior art keywords
bridged
inhibitors
gamma secretase
cyclic sulfonamido
sulfonamido
Prior art date
Application number
ZA200803521A
Other languages
English (en)
Inventor
Simeon Bowers
Albert W Garofalo
Roy K Hom
Andrei W Konradi
Matthew N Mattson
Martin L Neitzel
Christopher M Semko
Anh P Truong
Jing Wu
Ying-Zi Xu
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of ZA200803521B publication Critical patent/ZA200803521B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
ZA200803521A 2005-08-19 2008-04-22 Bridged N-cyclic sulfonamido inhibitors of gamma secretase ZA200803521B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70996105P 2005-08-19 2005-08-19

Publications (1)

Publication Number Publication Date
ZA200803521B true ZA200803521B (en) 2009-12-30

Family

ID=37758487

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200803521A ZA200803521B (en) 2005-08-19 2008-04-22 Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Country Status (16)

Country Link
US (4) US7345056B2 (xx)
EP (2) EP1915371A4 (xx)
JP (2) JP2009506988A (xx)
KR (1) KR20080042135A (xx)
CN (2) CN101426860A (xx)
AR (1) AR056470A1 (xx)
AU (2) AU2006279312A1 (xx)
BR (1) BRPI0614944A2 (xx)
CA (2) CA2632670A1 (xx)
EC (1) ECSP088293A (xx)
IL (2) IL189217A0 (xx)
MX (1) MX2008002234A (xx)
RU (2) RU2008110488A (xx)
TW (1) TW200740806A (xx)
WO (2) WO2007024651A2 (xx)
ZA (1) ZA200803521B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
EP1915371A4 (en) * 2005-08-19 2010-09-15 Elan Pharm Inc BREAKDOWN N-BICYCLIC SULPHONAMIDE INHIBITORS OF GAMMA LASE CRETEASE
TW200736255A (en) 2005-12-01 2007-10-01 Elan Pharm Inc 5-(Substituted)-pyrazolopiperidines
BRPI0812014A2 (pt) * 2007-05-25 2014-11-18 Elan Pharm Inc Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos
US8604195B2 (en) * 2007-08-15 2013-12-10 Merck Sharp & Dohme Corp. Substituted bicyclic piperidinyl- and piperazinyl-sulfonamides useful to inhibit 11β-hydroxysteroid dehydrogenase type-1
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US8546381B2 (en) 2008-03-24 2013-10-01 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
EA201170421A1 (ru) * 2008-09-05 2012-01-30 Элан Фармасьютикалз, Инк. N-сульфонамидопиразолильные полициклические соединения
BR112012006640A2 (pt) 2009-09-23 2019-09-24 Medivation Technologies Inc composto, composição farmacêutica, método de tratamento de um distúrbio cognitivo, distúrbiopsocótico, distúrbio mediado por neurotransmissor ou um distúrbio neuronal e kit
WO2011038164A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
MX2013002208A (es) 2010-08-23 2013-05-30 Amgen Inc Derivados de sulfonilpiperazina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes.
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
WO2013019901A2 (en) * 2011-08-02 2013-02-07 Buck Institute For Research On Aging Tropinol esters and related compounds to promote normal processing of app
EP2690102A1 (en) 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bicyclic aza-amides for treatment of psychiatric disorders
JP6556255B2 (ja) * 2015-05-25 2019-08-07 華為技術有限公司Ｈｕａｗｅｉ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｃｏ．，Ｌｔｄ． フォトクロミックレンズモジュール、カメラ、及び端末装置

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
JPH01132585A (ja) * 1987-11-17 1989-05-25 Kyowa Hakko Kogyo Co Ltd Ｄｃ−５２誘導体
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
JP3218621B2 (ja) * 1990-10-11 2001-10-15 住友化学工業株式会社 芳香族系化合物、その製造法およびそれを有効成分とする有害生物防除剤
GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
KR100266467B1 (ko) * 1995-09-27 2000-10-02 우에노 도시오 설폰아미드 유도체
EP1006113A1 (en) * 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
MXPA01009871A (es) * 1999-04-01 2002-04-24 Pfizer Prod Inc Aminopiridinas como inhibidores de la sorbitol deshidrogenasa.
DK1088819T3 (da) * 1999-09-30 2005-09-12 Pfizer Prod Inc 6-azauracilderivater som thyroidreceptorligander
EP1118612A1 (en) * 2000-01-21 2001-07-25 Universita Degli Studi di Firenze Piperazine derivatives possesing nootropic activity
MXPA03010255A (es) * 2001-05-10 2005-03-07 Agouron Pharma Ligandos heterobiciclicos de proteinas de union a fk-506.
GB0119152D0 (en) * 2001-08-06 2001-09-26 Merck Sharp & Dohme Therapeutic agents
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
TW200510405A (en) * 2003-05-13 2005-03-16 Schering Corp Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
CA2571058A1 (en) * 2004-06-22 2006-01-05 Schering Corporation Cannabinoid receptor ligands
CA2585172C (en) * 2004-10-29 2014-08-12 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
EP1915371A4 (en) * 2005-08-19 2010-09-15 Elan Pharm Inc BREAKDOWN N-BICYCLIC SULPHONAMIDE INHIBITORS OF GAMMA LASE CRETEASE

Also Published As

Publication number Publication date
RU2008110488A (ru) 2009-09-27
MX2008002234A (es) 2008-03-27
CA2632670A1 (en) 2007-02-22
TW200740806A (en) 2007-11-01
AR056470A1 (es) 2007-10-10
US20110178119A1 (en) 2011-07-21
IL190970A0 (en) 2009-02-11
EP1916985A4 (en) 2010-06-09
BRPI0614944A2 (pt) 2011-04-26
EP1915371A4 (en) 2010-09-15
ECSP088293A (es) 2008-04-28
US20070049612A1 (en) 2007-03-01
AU2006279312A1 (en) 2007-02-22
IL189217A0 (en) 2008-06-05
JP2009504773A (ja) 2009-02-05
AU2006283567A1 (en) 2007-03-01
WO2007022502A3 (en) 2007-10-04
WO2007024651A2 (en) 2007-03-01
EP1916985A2 (en) 2008-05-07
RU2008133306A (ru) 2010-02-20
US7754712B2 (en) 2010-07-13
US20110003802A1 (en) 2011-01-06
CN101426860A (zh) 2009-05-06
RU2422443C2 (ru) 2011-06-27
US20080090817A1 (en) 2008-04-17
KR20080042135A (ko) 2008-05-14
EP1915371A2 (en) 2008-04-30
CA2618087A1 (en) 2007-03-01
US7345056B2 (en) 2008-03-18
WO2007024651A3 (en) 2007-07-12
JP2009506988A (ja) 2009-02-19
WO2007022502A2 (en) 2007-02-22
CN101304997A (zh) 2008-11-12

Similar Documents

Publication Publication Date Title
ZA200803521B (en) Bridged N-cyclic sulfonamido inhibitors of gamma secretase
IL178392A0 (en) Novel gamma secretase inhibitors
PL2114955T3 (pl) Triazole podstawione mostkowanym bicyklicznym arylem oraz mostkowanym bicyklicznym heteroarylem użyteczne jako inhibitory Axl
ZA200602193B (en) Novel gamma secretase inhibitors
IL192906A0 (en) Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
ATE461926T1 (de) Substituierte n-arylsulfonylheterocyclische amine als gamma-sekretase-hemmer
ATE396990T1 (de) Makrocyclische inhibitoren der beta-sekretase
ZA200802585B (en) Pyridopyrimidinone inhibitors of Pl3Kα
IL190292A0 (en) PYRIDOPYRIMIDINONE INHIBITORS OF P13Ka
IL212497A0 (en) Heterocyclic gamma secretase modulators
ZA200610771B (en) Quinazolinedolone derivatives as PARP inhibitors
IL188398A0 (en) Thiazoles derivatives as ampk activator
ZA200800379B (en) Glutamate aggrecanase inhibitors
IL201960A0 (en) Gamma secretase modulators
EP1953151A4 (en) SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF
PL371735A1 (en) Gamma secretase inhibitors
ATE401328T1 (de) Verbrückte n-arylsulfonylpiperidine als gamma- sekretaseinhibitoren
IL195078A0 (en) Fused, tricyclic sulfonamide inhibitors of gamma secretase
IL202315A0 (en) Gamma secretase modulators
IL198014A0 (en) Heterocyclic derived metalloprotease inhibitors
ZA200908919B (en) Pyrazolopyrrolidines as inhibitors of gamma secretase
ZA200808190B (en) Malonamide derivatives as gamma secretase inhibitors
IL202316A0 (en) Gamma secretase modulators
EP1942101A4 (en) INHIBITOR OF -SECRETASE
BRPI0817789A2 (pt) Intermediários de moduladores de gama secretase (gsm)