TW200740806A - Bridged N-cyclic sulfonamido inhibitors of gamma secretase - Google Patents

Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Info

Publication number
TW200740806A
TW200740806A TW095130664A TW95130664A TW200740806A TW 200740806 A TW200740806 A TW 200740806A TW 095130664 A TW095130664 A TW 095130664A TW 95130664 A TW95130664 A TW 95130664A TW 200740806 A TW200740806 A TW 200740806A
Authority
TW
Taiwan
Prior art keywords
formula
compounds
bridged
inhibitors
gamma secretase
Prior art date
Application number
TW095130664A
Other languages
English (en)
Inventor
Simeon Bowers
Albert W Garofalo
Roy K Hom
Andrei W Konradi
Matthew N Mattson
Martin L Neitzel
Chris M Semko
Anh P Truong
Jing Wu
Ying-Zi Xu
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of TW200740806A publication Critical patent/TW200740806A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
TW095130664A 2005-08-19 2006-08-21 Bridged N-cyclic sulfonamido inhibitors of gamma secretase TW200740806A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70996105P 2005-08-19 2005-08-19

Publications (1)

Publication Number Publication Date
TW200740806A true TW200740806A (en) 2007-11-01

Family

ID=37758487

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095130664A TW200740806A (en) 2005-08-19 2006-08-21 Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Country Status (16)

Country Link
US (4) US7345056B2 (zh)
EP (2) EP1916985A4 (zh)
JP (2) JP2009506988A (zh)
KR (1) KR20080042135A (zh)
CN (2) CN101304997A (zh)
AR (1) AR056470A1 (zh)
AU (2) AU2006279312A1 (zh)
BR (1) BRPI0614944A2 (zh)
CA (2) CA2618087A1 (zh)
EC (1) ECSP088293A (zh)
IL (2) IL189217A0 (zh)
MX (1) MX2008002234A (zh)
RU (2) RU2008110488A (zh)
TW (1) TW200740806A (zh)
WO (2) WO2007022502A2 (zh)
ZA (1) ZA200803521B (zh)

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* Cited by examiner, † Cited by third party
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US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
WO2007022502A2 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged n-cyclic sulfonamido inhibitors of gamma secretase
CA2632227A1 (en) * 2005-12-01 2007-06-07 Elan Pharmaceuticals, Inc. 5-(arylsulfonyl)-pyrazolopiperidines
NZ582039A (en) 2007-05-25 2012-02-24 Elan Pharm Inc Pyrazolopyrrolidines as inhibitors of gamma secretase
CN101821265A (zh) * 2007-08-15 2010-09-01 先灵公司 可用于抑制1型11β-羟基类固醇脱氢酶的取代的双环哌啶基-和哌嗪基-磺酰胺
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
AU2009228401B2 (en) 2008-03-24 2014-10-30 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
AU2009289579A1 (en) * 2008-09-05 2010-03-11 Elan Pharmaceuticals, Inc. N-sulfonamido polycyclic pyrazolyl compounds
CA2775328A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[4,3-b]indoles and methods of use
JP5869484B2 (ja) 2009-09-23 2016-02-24 メディベイション テクノロジーズ， インコーポレイテッド 架橋複素環化合物およびその使用
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
AU2011293584B2 (en) 2010-08-23 2014-07-31 Amgen Inc. Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes
EP2675458A4 (en) 2011-02-18 2014-08-06 Medivation Technologies Inc COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE
WO2013019901A2 (en) * 2011-08-02 2013-02-07 Buck Institute For Research On Aging Tropinol esters and related compounds to promote normal processing of app
EP2690102A1 (en) * 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bicyclic aza-amides for treatment of psychiatric disorders
CN107407856B (zh) * 2015-05-25 2019-11-29 华为技术有限公司 一种光致变色镜头、摄像头及终端设备

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US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
JPH01132585A (ja) * 1987-11-17 1989-05-25 Kyowa Hakko Kogyo Co Ltd Ｄｃ−５２誘導体
US5256656A (en) * 1990-07-31 1993-10-26 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives
JP3218621B2 (ja) * 1990-10-11 2001-10-15 住友化学工業株式会社 芳香族系化合物、その製造法およびそれを有効成分とする有害生物防除剤
GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
US5795890A (en) * 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
EP1006113A1 (en) * 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
IL145364A0 (en) * 1999-04-01 2002-06-30 Pfizer Prod Inc Aminopyrimidines as sorbitol dehydrogenase inhibitors
DK1088819T3 (da) 1999-09-30 2005-09-12 Pfizer Prod Inc 6-azauracilderivater som thyroidreceptorligander
EP1118612A1 (en) * 2000-01-21 2001-07-25 Universita Degli Studi di Firenze Piperazine derivatives possesing nootropic activity
JP2004532854A (ja) * 2001-05-10 2004-10-28 アグロン ファ−マシュ−テイカルズ インコ−ポレイテッド 複素２環式ｆｋｂｐリガンド
GB0119152D0 (en) * 2001-08-06 2001-09-26 Merck Sharp & Dohme Therapeutic agents
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
WO2004101562A2 (en) * 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
MX2007000015A (es) * 2004-06-22 2007-03-07 Schering Corp Ligandos de receptor de canabinoide.
EP1805158B1 (en) * 2004-10-29 2018-06-27 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
WO2007022502A2 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged n-cyclic sulfonamido inhibitors of gamma secretase

Also Published As

Publication number Publication date
AU2006283567A1 (en) 2007-03-01
AR056470A1 (es) 2007-10-10
RU2008110488A (ru) 2009-09-27
CN101304997A (zh) 2008-11-12
EP1916985A4 (en) 2010-06-09
KR20080042135A (ko) 2008-05-14
WO2007022502A3 (en) 2007-10-04
JP2009504773A (ja) 2009-02-05
IL189217A0 (en) 2008-06-05
CN101426860A (zh) 2009-05-06
EP1915371A4 (en) 2010-09-15
JP2009506988A (ja) 2009-02-19
ECSP088293A (es) 2008-04-28
IL190970A0 (en) 2009-02-11
US7754712B2 (en) 2010-07-13
MX2008002234A (es) 2008-03-27
US20110003802A1 (en) 2011-01-06
US20080090817A1 (en) 2008-04-17
WO2007024651A2 (en) 2007-03-01
WO2007022502A2 (en) 2007-02-22
US7345056B2 (en) 2008-03-18
CA2618087A1 (en) 2007-03-01
RU2422443C2 (ru) 2011-06-27
EP1915371A2 (en) 2008-04-30
US20070049612A1 (en) 2007-03-01
RU2008133306A (ru) 2010-02-20
US20110178119A1 (en) 2011-07-21
BRPI0614944A2 (pt) 2011-04-26
ZA200803521B (en) 2009-12-30
EP1916985A2 (en) 2008-05-07
CA2632670A1 (en) 2007-02-22
WO2007024651A3 (en) 2007-07-12
AU2006279312A1 (en) 2007-02-22

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