WO2006059395A1 - Préparation cutanée à usage externe permettant de stimuler la production de collagène - Google Patents

Préparation cutanée à usage externe permettant de stimuler la production de collagène Download PDF

Info

Publication number
WO2006059395A1
WO2006059395A1 PCT/JP2004/018240 JP2004018240W WO2006059395A1 WO 2006059395 A1 WO2006059395 A1 WO 2006059395A1 JP 2004018240 W JP2004018240 W JP 2004018240W WO 2006059395 A1 WO2006059395 A1 WO 2006059395A1
Authority
WO
WIPO (PCT)
Prior art keywords
pine bark
extract
weight
skin
collagen production
Prior art date
Application number
PCT/JP2004/018240
Other languages
English (en)
Japanese (ja)
Inventor
Kinya Takagaki
Takeshi Mitsui
Original Assignee
Toyo Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Shinyaku Co., Ltd. filed Critical Toyo Shinyaku Co., Ltd.
Priority to PCT/JP2004/018240 priority Critical patent/WO2006059395A1/fr
Publication of WO2006059395A1 publication Critical patent/WO2006059395A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to a collagen production-enhancing skin external preparation containing a pine bark extract.
  • Collagen is the main component of skin or blood vessels.
  • collagen production (synthetic capacity) decreases due to aging, uneven nutrition intake due to unbalanced diets, etc., and this decrease in collagen production causes skin wrinkles and sagging.
  • the present inventors have found that the amount of collagen in the skin is remarkably enhanced by orally ingesting a pine bark extract already containing proanthocyanidins (for example, JP-A-2003-146899). ) Pine bark extract that has an excellent collagen production enhancing effect by such ingestion. When it was used as an external preparation such as cosmetics and quasi-drugs, it was not studied whether transdermal administration (application) with completely different absorption processes in the body would have the same effect as oral administration. Disclosure of the invention
  • An object of the present invention is to provide a skin external preparation having an excellent collagen production enhancing effect.
  • the present inventors When the pine bark extract is used as an external preparation for skin, the present inventors surprisingly have an effect of enhancing collagen production equivalent to that of oral intake, and this effect reduces collagen production.
  • the present invention has been completed by finding that it can be obtained even in a state in which it is present.
  • the present invention provides a skin preparation for enhancing collagen production containing a pine bark extract.
  • the pine bark extract contains oligomeric proanthocyanidin in terms of dry weight.
  • the pine bark extract further contains catechins (Ga techin) in a proportion of 5% by weight or more in terms of dry weight.
  • the external preparation for skin of the present invention has an excellent collagen production enhancing effect when applied to the skin.
  • the pine bark extract contained in the external preparation for skin of the present invention has an excellent collagen production enhancing effect compared to other plant extracts containing the same level of proanthocyanidins.
  • a pine husk extract containing 20% by weight or more of OPC in terms of dry weight and further containing 5% by weight of catechins in terms of dry weight can exhibit a particularly excellent collagen production enhancing effect.
  • Such a pine bark extract is preferably obtained by extraction with mature water. 0
  • the collagen production-enhancing skin external preparation of the present invention contains a pine bark extract.
  • the pine bark used as the raw material for this pine bark extract is the French pine (Pinus Martiraa), larch, black pine, waka pine, Japanese pine, goyo pine, Korean pine, high pine, Ryukyu pine, luck pine, dai pine Bark of white pine, Kaneda in Canada's Quebec region is preferably used.
  • the bark of French coastal pine (Pinus Martima) is preferably used.
  • French coastal pine is a marine pine that grows on the Atlantic coast of southern France.
  • the bark of French coastal pine contains proanthocyanidins, organic acids and other physiologically active ingredients.
  • Proanthocyanidins refer to a group of compounds consisting of a condensation polymer having a degree of polymerization of 2 or more and comprising flavan 1-ol and / or flavan-3,4-diole as a structural unit. It is known that proanthocyanin, which is the main component, has a strong resistance to acid removal that removes active oxygen.
  • the pine bark extract used in the present invention is obtained by extracting the above pine bark with water or an organic solvent.
  • organic solvents used for extraction include methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-pentanol, acetone, hexane, cyclohexane, propylene glycol, hydrous ethanol, hydrous propylene glycoleno, and methinoretino.
  • Organic solvents that are acceptable for the production of pharmaceuticals or drugs such as reketones, glycerin, methinole acetate, ethyl acetate / le, jetyl ether, dichloromethane, edible fats and oils, 1, 1, 1, 2-tetrafluoroethane are preferred. Used. These aqueous organic solvents may be used alone or in combination. In particular, hot water, ethanol, hydrous ethanol, hydropropylene glycol and the like are preferable, hot water and ethanol are more preferable, and hot water is more preferably used.
  • the pine bark extract obtained by hot water extraction of pine bark has a superior collagen production enhancing effect compared to the pine bark extract obtained by other extraction methods.
  • the extraction method from pine bark is not particularly limited, but for example, a warm extraction method or a supercritical fluid extraction method is used.
  • Supercritical fluid extraction is a method that uses a supercritical fluid, which is a fluid that exceeds the critical point (critical temperature, critical pressure) of a substance's gas-liquid. Carbon dioxide, ethylene, propane, nitrous oxide (laughing gas), etc. are used as the supercritical fluid, and carbon dioxide is preferably used.
  • a supercritical fluid which is a fluid that exceeds the critical point (critical temperature, critical pressure) of a substance's gas-liquid.
  • Carbon dioxide, ethylene, propane, nitrous oxide (laughing gas), etc. are used as the supercritical fluid, and carbon dioxide is preferably used.
  • an extraction process for extracting a target component with a supercritical fluid and a separation process for separating the target component and the supercritical fluid are performed.
  • the separation step any one of extraction separation by pressure change, extraction separation by temperature change, or extraction separation using an adsorbent 'absorbent' may be performed.
  • supercritical fluid extraction may be performed by an entrainer addition method.
  • ethanol, propanol, ⁇ -hexane, acetone, toluene, other aliphatic lower alcohols, aliphatic hydrocarbons, aromatic hydrocarbons, or ketones are added to a supercritical fluid.
  • target extracts such as proanthocyanidins, OPCs, and catechins.
  • the supercritical fluid extraction method can be operated at a relatively low temperature, so it can be applied to substances that are altered and decomposed at high temperatures; the advantage that no extracted fluid remains; 18240
  • the solvent can be recycled and the desolvation process can be omitted, and the process becomes simple.
  • Extraction from pine bark may be performed by a liquid carbon dioxide batch method, a liquid carbon dioxide reflux method, a supercritical diacid carbon reflux method, or the like, in addition to the above method.
  • the extraction of pine bark may be a combination of multiple extraction methods. By combining a plurality of extraction methods, it becomes possible to obtain pine bark extracts having various compositions.
  • the pine bark extract obtained by the above extraction may be purified for the purpose of increasing the content of proanthocyanidins.
  • a solvent such as ethyl acetate is usually used, but from the viewpoint of safety, a method that does not use a solvent to facilitate application to skin cosmetics and quasi-drugs as an external preparation,
  • an adsorptive carrier such as Diaion HP-20, Cefadex LH20, and chitin.
  • the pine bark extract used in the external preparation for skin of the present invention is prepared by the following method, but this is an example, and the present invention is not limited to this method.
  • 1 kg of French coastal pine bark is placed in 3 L of a saturated aqueous solution of sodium chloride and extracted at 100 ° C for 30 minutes to obtain an extract (extraction process). Thereafter, the extract is filtered, and the resulting insoluble matter is washed with 50 O mL of a saturated solution of sodium chloride to obtain a washing solution (washing step). The extract and washing solution are combined to obtain a crude extract of pine bark.
  • the pine bark extract used in the present invention contains proanthocyanidins.
  • proanthocyanidins When this pine husk extract containing proanthocyanidins is applied to the skin, the same excellent collagen production enhancing effect as that obtained when taken orally is obtained.
  • those containing a condensation polymer having a low degree of polymerization are preferably used from the viewpoint of excellent absorbability and penetration into the skin.
  • those containing a condensation polymer having a degree of polymerization of 2 to 30 (2 to 30 mer) are preferred, and those containing a condensation polymer having a degree of polymerization of 2 to 10 (2 to 10 mer) are more preferred.
  • OPC oligomeric proanthocyanidin N
  • OPC oligomeric proanthocyanidin N
  • OPC a type of polyphenol, is a powerful antioxidant produced by plants and is concentrated in plant leaves, bark, fruit peels and seed parts. Specifically, it is contained in grape seeds, pine bark, peanut skin, yew, diacacia fruit, and cowberry. It is also known that West African cola nuts, Peruvian Latania roots, and Japanese green tea contain OPC. When applied to the skin, OPC exerts an anti-oxidative effect, suppresses the growth of oral pacteria, reduces plaque, and restores the elasticity of blood vessels.
  • proanthocyanidins are 40% by weight or more, preferably 40% by weight to 90% by weight, more preferably 50% by weight in terms of dry weight in the extract. /. It is contained at a ratio of ⁇ 80% by weight. And extract OPC It is preferably 20% by weight or more, more preferably 30% by weight in terms of dry weight in the product. / Contains at a ratio of 0 or more.
  • the pine bark extract preferably further contains catechins in a proportion of 5% by weight or more.
  • Catechins can be extracted together with oral anthocyanidins (OPC) by the above extraction method.
  • Catechin is a general term for polyhydroxyflavan 1-3-ol.
  • the catechins include: (+) One-handed techin (referred to as catechin in the narrow sense), (1) -epicatechin, (+) -gallocatechin, (1) -epigalocatechin, epigallocatechin gallate, epicatechin gallate Affzerekin is known. From the above-mentioned pine bark extract, in addition to the above (+)-powered techin, gallocatechin and affazechin, and (+) -powered tekin or 3-galloyl derivatives of gallocatechin have been isolated.
  • Catechins have the property of activating OPC at the same time as increasing water solubility in the presence of OPC, and can also contribute to the stability of OPC.
  • the pine bark extract used in the present invention contains OPC in a proportion of 20% by weight or more, and contains strong tekins in a proportion of 5% by weight or more.
  • the catechins do not satisfy the above content, it is preferable to add the catechins so as to contain 5% by weight or more.
  • Enhancing collagen production skin external preparation of the present invention a pine bark extract, 0 preferably dry weight. 0 0 0 5-2 0. 0 wt 0/0, more preferably 0. 0 0 1-1 0 Contains 0% by weight. 0. If it is 0 0 0 less than 5 wt 0/0, collagen production enhancing effect is not sufficiently exhibited, 2 0. When more than 0 wt%, to become a flame formulation coma, which is not preferable.
  • the collagen production-enhancing skin external preparation of the present invention is an ingredient usually used in cosmetics, pharmaceuticals, etc.
  • Antioxidants, whitening agents, moisturizers, oil components, surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, various skin nutrients, etc. as appropriate Can be blended.
  • the anti-oxidation agent can be added to prevent the oxidation of components usually used as a skin external preparation.
  • Antioxidants include ascorbic acid and its derivatives, SOD, mannitol, carotenoids (astaxanthin, etc.), hydroquinone, ubiquinone, vinorevirin, cholesterol, tryptophan, histidine, vitamin P-like substances (rutin, quercetin, hesperidin, etc.) ) Plant extracts with antioxidant activity such as gallic acid, vitamin B, vitamin D or its derivatives, vitamin E, glutathione, argon, rosemary and the like.
  • Such an anti-oxidation agent is preferably contained in the external preparation for skin in an amount of 0.01 to 40% by weight, more preferably 0.01 to 20% by weight.
  • ascorbic acid opioid derivative is preferably 0.01 to 30% by weight, more preferably 0.01 to 10% by weight, in the external preparation for skin. Contains 0 .
  • the form of the external preparation for skin of the present invention is not particularly limited, and any form may be used as long as it is a form conventionally used for external preparations for skin, such as an ointment, cream, emulsion, mouth lotion, pack, ship, bath preparation and the like. Further, it may be applied to the mouth cavity and mouth mucous membrane such as mouthwash, toothpaste and eye drops.
  • the external preparation for skin of the present invention has an excellent collagen production enhancing effect when applied to the skin.
  • the topical skin preparation of the present invention can reduce the amount of collagen in a living body in a short period of time even in a state in which collagen productivity is reduced, for example, in a state in which ascorbic acid opiate derivative (vitamin C) is deficient. It can be restored to the state. This effect is demonstrated by dermal administration, superior to when vitamin C is taken orally, and equivalent to that when pine bark extract is taken orally. 4 018240
  • vitamin C is indispensable for collagen synthesis, and supplementation with vitamin C is indispensable for enhancing collagen production.
  • the topical skin preparation of the present invention can be administered orally or transdermally. An excellent collagen production enhancing effect can be exhibited without depending on administration.
  • the pine bark extract contained in the external preparation for skin of the present invention has an excellent collagen production enhancing effect as compared with other plant extracts containing the same level of proanthocyanin.
  • OPC is 20 weight in terms of dry weight.
  • a pine bark extract containing 0 or more and further containing 5% by weight of catechins in terms of dry weight can exhibit a particularly excellent collagen production enhancing effect.
  • Such a pine bark extract is preferably obtained by hot water extraction.
  • Pine bark extract has an effect not found in conventional collagen production enhancers in that it can enhance collagen production not only by oral intake but also by transdermal administration.
  • Purified water (7.2 L) was added to 900 g of pine bark, and the mixture was broken with a blender (Waring Blender) and heated at 100 ° C. for 10 minutes. Then, it was immediately filtered to obtain a filtrate. The residue after filtration was washed with 1.8 L of purified water, and the filtrate and the washing solution were combined to obtain 9 L of a crude hot water extract of pine bark. When this crude extract I mL was lyophilized, the dry weight was 8 mg.
  • aqueous solution containing 0.3% by weight of a dry powder of the hot water extract of pine bark obtained in Production Example 1 was prepared. This aqueous solution was applied to the following test guinea pigs, and the amount of hydroxyproline (H y P) and the thickness of the dermis, which are indicators of the amount of collagen in the skin before and after application, were measured, and the collagen production enhancing effect was evaluated.
  • H y P hydroxyproline
  • the thickness of the dermis which are indicators of the amount of collagen in the skin before and after application
  • the amount of hypo was measured as follows. Remove the skin from the guinea pig,
  • the thickness of the dermis was measured as follows. Remove the skin from the guinea pig,
  • one group of guinea pigs received basic feed and served as a control group.
  • Eight groups of guinea pigs were allowed to freely take a low vitamin C diet (CG-7: Nippon Claire Co., Ltd., vitamin C content 0.01% by weight) for 2 weeks to reduce the amount of collagen in the skin. After ingesting for 2 weeks, the skin was removed from one of the groups and the amount of Hyp skin and the thickness of the dermis were measured as described above. 44. 2 mgZg skin and 1.30 ⁇ 0.08 mm. The remaining 7 groups of guinea pigs that received low-vitamin C diet were removed with palican and used as test guinea pigs.
  • CG-7 Nippon Claire Co., Ltd., vitamin C content 0.01% by weight
  • Example 2 an aqueous solution containing 0.3% by weight of a dry powder of ethanol extract of pine bark obtained in Production Example 2 (Example 2) and pine bark
  • Example 3 an aqueous solution containing 0.3% by weight of a dry powder of hot water extract and 0.3% by weight of vitamin C (Example 3) was used.
  • the test was applied to a group of test guinea pigs, and the amount of hypoposis of the skin was measured. The results are shown in Table 1. (Comparative Examples 1 to 4)
  • Example 1 an aqueous solution containing 0.3% by weight of Pudou Seed Extract (Kikkoman Corporation) containing 38% by weight of proanthocyanidins (Comparative Example 1) and In the same manner as in Example 1 except that purified water (Comparative Examples 2 and 3) was used, each of the above aqueous solutions was applied to a group of test guinea pigs. One group of guinea pigs was further coated with purified water, instead of low vitamin C diet, basic diet (vitamin C 0. 1 7 wt 0/0 containing) (Comparative Example 3).
  • the remaining one group of guinea pigs was not allowed to apply anything, and was allowed to freely ingest a feed containing 3% by weight of the hot water extract of pine bark obtained in Production Example 1 in a low vitamin C feed. (Comparative Example 4).
  • the amount of Hyp and the thickness of the dermis of these guinea pig skins were measured in the same manner as in Example 1. The results are shown in Table 1.
  • Example 4 the effect of enhancing the collagen production of this pine bark extract is the effect of the pine bark extract alone, without depending on the transdermal administration of vitamin C, as compared with Example 1 and Example 3.
  • a comparison between Example 1 and Example 2 shows that the hot water extract of pine husk is superior to the ethanol extract. (Example 4)
  • this emollient cream has the effect of enhancing the production of lagen and is useful as an external preparation for skin:
  • the hot water extract of pine bark obtained in Production Example 1 and the following components were uniformly mixed and stirred to prepare a mouthwash.
  • This mouthwash can be expected to increase the amount of collagen produced mainly by the gums that support the teeth and prevent tooth wobble, etc .:
  • An ophthalmic solution was prepared by uniformly mixing and stirring the hot water extract of pine bark obtained in Production Example 1 and the following components:
  • composition of ophthalmic solution > (Unit:% by weight) Pine bark extract (hot water extract) 0. 01 Sodium salt sodium salt 0. 7 Potassium chloride 0. 2 Natrium azulene sulfonate 0. 02 Chronoleuramine maleate 0 . 3 Water 9 8.7 7 Industrial applicability
  • the external preparation for skin of the present invention has an excellent collagen production enhancing effect when applied to the skin.
  • the pine bark extract contained in the external preparation for skin of the present invention has an excellent collagen production enhancing effect as compared with other plant extracts containing the same level of proanthocyanin.
  • a pine bark extract containing OPC in an amount of 20% by weight or more in terms of dry weight and further containing 5 % by weight of strength techins in terms of dry weight can exhibit a particularly excellent collagen production enhancing effect.
  • Such a pine bark extract is preferably obtained by hot water extraction.
  • the external preparation for skin of the present invention is a form used for conventional external preparations for skin, such as ointments, creams, emulsions, lotions, packs, ships, bathing agents, etc., and forms applied to the oral cavity and eye mucous membranes such as mouthwash, toothpaste, eye drops, etc. It can be used as such.

Abstract

La présente invention a pour objet une préparation cutanée à usage externe permettant de stimuler la production de collagène et qui contient un extrait d'écorce de pin. L’extrait d'écorce de pain contenu dans la préparation cutanée à usage externe contient préférentiellement au moins 20 % en masse d'OPC par rapport à la masse sèche et au moins 5 % d'un dérivé de catéchine par rapport à la masse sèche. La préparation cutanée à usage externe est très efficace pour ce qui est de la stimulation de la production de collagène.
PCT/JP2004/018240 2004-12-01 2004-12-01 Préparation cutanée à usage externe permettant de stimuler la production de collagène WO2006059395A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2004/018240 WO2006059395A1 (fr) 2004-12-01 2004-12-01 Préparation cutanée à usage externe permettant de stimuler la production de collagène

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2004/018240 WO2006059395A1 (fr) 2004-12-01 2004-12-01 Préparation cutanée à usage externe permettant de stimuler la production de collagène

Publications (1)

Publication Number Publication Date
WO2006059395A1 true WO2006059395A1 (fr) 2006-06-08

Family

ID=36564838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/018240 WO2006059395A1 (fr) 2004-12-01 2004-12-01 Préparation cutanée à usage externe permettant de stimuler la production de collagène

Country Status (1)

Country Link
WO (1) WO2006059395A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110652475A (zh) * 2018-06-29 2020-01-07 伽蓝（集团）股份有限公司 甘松提取物的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02134309A (ja) * 1988-11-16 1990-05-23 Kikkoman Corp 美白化粧料
JPH06336422A (ja) * 1993-05-28 1994-12-06 Kose Corp 皮膚外用剤
WO2001032131A1 (fr) * 1999-10-29 2001-05-10 Kyowa Hakko Kogyo Co., Ltd. Agents d'amelioration de texture de la peau
JP2003146899A (ja) * 2001-11-09 2003-05-21 Toyo Shinyaku:Kk 皮膚改善剤
JP2003238426A (ja) * 2002-02-18 2003-08-27 Toyo Shinyaku:Kk コラゲナーゼ阻害剤、皮膚外用剤および健康食品
JP2003277223A (ja) * 2002-03-19 2003-10-02 Dhc Co マトリックスメタロプロテアーゼ活性阻害剤および皮膚弾力性維持化粧料。
JP2004149441A (ja) * 2002-10-30 2004-05-27 Toyo Shinyaku:Kk 皮膚外用剤
JP2004359640A (ja) * 2003-06-06 2004-12-24 Toyo Shinyaku:Kk コラーゲン産生増強皮膚外用剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02134309A (ja) * 1988-11-16 1990-05-23 Kikkoman Corp 美白化粧料
JPH06336422A (ja) * 1993-05-28 1994-12-06 Kose Corp 皮膚外用剤
WO2001032131A1 (fr) * 1999-10-29 2001-05-10 Kyowa Hakko Kogyo Co., Ltd. Agents d'amelioration de texture de la peau
JP2003146899A (ja) * 2001-11-09 2003-05-21 Toyo Shinyaku:Kk 皮膚改善剤
JP2003238426A (ja) * 2002-02-18 2003-08-27 Toyo Shinyaku:Kk コラゲナーゼ阻害剤、皮膚外用剤および健康食品
JP2003277223A (ja) * 2002-03-19 2003-10-02 Dhc Co マトリックスメタロプロテアーゼ活性阻害剤および皮膚弾力性維持化粧料。
JP2004149441A (ja) * 2002-10-30 2004-05-27 Toyo Shinyaku:Kk 皮膚外用剤
JP2004359640A (ja) * 2003-06-06 2004-12-24 Toyo Shinyaku:Kk コラーゲン産生増強皮膚外用剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110652475A (zh) * 2018-06-29 2020-01-07 伽蓝（集团）股份有限公司 甘松提取物的应用

Similar Documents

Publication Publication Date Title
JP2004359640A (ja) コラーゲン産生増強皮膚外用剤
JP3502415B2 (ja) メイラード反応阻害剤
JP2004123622A (ja) 血流改善外用剤
JP2005029486A (ja) 皮膚改善組成物
JPH08259431A (ja) メイラード反応阻害剤及びそれを含有する皮膚外用剤
JP2000256176A (ja) 皮膚化粧料
JP6173362B2 (ja) 皮膚バリア機能改善剤、細胞間接着構造の形成促進剤、タイトジャンクション形成促進剤、ＴＲＰＶ４活性化剤、細胞内Ｃａ濃度上昇亢進剤及び皮脂産生促進剤
JP5426844B2 (ja) 生体コラーゲン合成促進剤
JP3533392B1 (ja) 皮膚外用剤
JP2012031086A (ja) 抗酸化剤及び化粧料
KR101802355B1 (ko) 감귤류 과피 추출물을 포함하는 피부 조직 재생용 조성물
JP4648309B2 (ja) プロアントシアニジン水可溶性結合体およびそれを含有する組成物
JP2000212058A (ja) 皮膚化粧料、活性酸素消去剤、エラスタ―ゼ阻害剤およびコラゲナ―ゼ阻害剤
WO2006059395A1 (fr) Préparation cutanée à usage externe permettant de stimuler la production de collagène
JP2005023021A (ja) エラスターゼ阻害剤
JP2003238426A (ja) コラゲナーゼ阻害剤、皮膚外用剤および健康食品
JPS5913709A (ja) モイスチヤライザ−
JP2008303180A (ja) 美白剤、皮膚外用剤及び機能性経口組成物
JP2003238425A (ja) チロシナーゼ阻害剤および皮膚外用剤
JP2004315476A (ja) ヒアルロニダーゼ阻害剤
KR101114499B1 (ko) 풍류과 및 야관문으로부터 수득된 피부 미백 및 노화 방지용 혼합 생약재 추출물 및 이를 함유하는 화장료 조성물
JP4222973B2 (ja) エラスターゼの活性阻害剤および化粧品
JP2009221173A (ja) ケラチン状態改善剤
WO2007010911A1 (fr) Agent pour soulager une plaie et en faciliter la guérison
JP4222760B2 (ja) ２−メトキシ−４−グルコサミノメチルフェノール

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 04801620

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 04801620

Country of ref document: EP

Kind code of ref document: A1

WWW Wipo information: withdrawn in national office

Ref document number: 4801620

Country of ref document: EP