WO2007010911A1 - Agent pour soulager une plaie et en faciliter la guérison - Google Patents

Agent pour soulager une plaie et en faciliter la guérison Download PDF

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Publication number
WO2007010911A1
WO2007010911A1 PCT/JP2006/314213 JP2006314213W WO2007010911A1 WO 2007010911 A1 WO2007010911 A1 WO 2007010911A1 JP 2006314213 W JP2006314213 W JP 2006314213W WO 2007010911 A1 WO2007010911 A1 WO 2007010911A1
Authority
WO
WIPO (PCT)
Prior art keywords
recovery
pine bark
bark extract
wound
mass
Prior art date
Application number
PCT/JP2006/314213
Other languages
English (en)
Japanese (ja)
Inventor
Kinya Takagaki
Original Assignee
Toyo Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Shinyaku Co., Ltd. filed Critical Toyo Shinyaku Co., Ltd.
Priority to JP2007526021A priority Critical patent/JPWO2007010911A1/ja
Publication of WO2007010911A1 publication Critical patent/WO2007010911A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • the present invention relates to a trauma mitigation and recovery promoter.
  • An object of the present invention is to provide an excellent trauma reduction and recovery promoter with high safety.
  • the present inventor has intensively studied a raw material derived from a natural product having an effect of reducing trauma and promoting recovery. As a result, it has been found that administration of a pine bark extract can provide excellent trauma reduction and recovery promoting effects, and the present invention has been completed.
  • the trauma alleviation and recovery promoter of the present invention is characterized by containing a pine bark extract.
  • the trauma is a burn or a chemical injury.
  • the pine bark extract contains 30% by mass or more of oligomeric broanthocyanidin.
  • the trauma alleviation and recovery promoter of the present invention is also characterized by oral administration.
  • the trauma mitigation and recovery promoter of the present invention reduces the skin damage caused by trauma, particularly burns or chemical injury, by administration in advance, or recovers skin damage by regenerating the epidermis by administration after skin injury. Can be promoted.
  • the trauma mitigation and recovery promoter of the present invention exhibits an excellent trauma mitigation and recovery promoting effect both in oral administration and transdermal administration.
  • the trauma alleviation and recovery promoter of the present invention is characterized by containing a pine bark extract.
  • French coast pine Pieris M artima
  • French coastal pine is a marine pine that grows on the Atlantic coast of southern France. This French coastal pine bark contains proanthocyanidins, organic acids, and other physiologically active ingredients.
  • Proanthocyanidins refer to a group of compounds composed of a condensation polymer having a degree of polymerization of 2 or more, with furan-1-3-ol and furan or furan-1,3-diol as structural units.
  • Proanthocyanidin which is the main component, is known to have a strong antioxidant action to remove active oxygen.
  • the pine bark extract is obtained by extracting the pine bark with a solvent (for example, water or an organic solvent).
  • a solvent for example, water or an organic solvent.
  • water warm water or hot water is used.
  • organic solvent used for extraction an organic solvent that is acceptable for the production of foods or drugs is preferably used.
  • water and organic solvents may be used alone or in combination.
  • hot water, hydrous ethanol, and hydrous propylene glycol are preferably used.
  • the extraction method from pine bark is not particularly limited.
  • a warm extraction method or a supercritical fluid extraction method is used.
  • Supercritical fluid extraction is a method that uses a supercritical fluid, which is a fluid that exceeds the critical point (critical temperature, critical pressure) of a substance's gas-liquid. Carbon dioxide, ethylene, propane, nitrous oxide (laughing gas), etc. are used as supercritical fluids. Carbon dioxide is preferably used.
  • an extraction process that extracts the target component with a supercritical fluid.
  • a separation step of separating the target component and the supercritical fluid any one of extraction separation by pressure change, extraction separation by temperature change, or extraction separation using an adsorbent 'absorbent' may be performed.
  • supercritical fluid extraction may be performed by an entrainer addition method.
  • ethanol, propanol, n-hexane, acetone, toluene, other aliphatic lower alcohols, aliphatic hydrocarbons, aromatic hydrocarbons, or ketones are added to a supercritical fluid.
  • the solubility of the target extract such as proanthocyanidins and catechins (described later) in the extraction solvent is dramatically increased.
  • it is a method for enhancing the selectivity of separation, and a method for efficiently obtaining a pine bark extract.
  • the supercritical fluid extraction method can be operated at a relatively low temperature, so it can be applied to substances that are altered and decomposed at high temperatures; the advantage is that the extraction fluid does not remain; and the recycling of the solvent is possible. There is an advantage that the solvent process can be omitted and the process becomes simple.
  • methods for obtaining an extract from pine bark include a liquid carbon dioxide batch method, a liquid carbon dioxide reflux method, and a supercritical carbon dioxide reflux method.
  • pine bark extracts For extraction from pine bark, a plurality of extraction methods may be combined. It is edible to obtain pine bark extracts with various compositions by combining multiple extraction methods.
  • the administration form oral administration or transdermal administration
  • water or ethanol is used to synthesize a synthetic adsorbent (Diamond (registered trademark) HP-20, Cefadex. (Registered trademark) LH20, ampalite (registered trademark) XAD-4, etc.) and pine bark extract obtained by ultrafiltration are preferable from the viewpoint of safety.
  • a synthetic adsorbent Diamond (registered trademark) HP-20, Cefadex. (Registered trademark) LH20, ampalite (registered trademark) XAD-4, etc.
  • pine bark extract obtained by ultrafiltration are preferable from the viewpoint of safety.
  • the pine bark extract used in the present invention contains proanthocyanidins.
  • This proanthocyanidin covers a condensation polymer having a degree of polymerization of 2 to 30 (2 to 30 mer), but in the present invention, a large amount of a condensation polymer having a degree of polymerization of 2 to 4 (2 to 4 mer) is used. It is preferable to include.
  • condensation polymer having a degree of polymerization of 2 to 4 is referred to as an oligomeric proanthocyanin (o l i gome r i c p ro a n t o c y a n i din: OPC).
  • O P c is a kind of polyphenols, a powerful antioxidant produced by plants, and is concentrated in plant leaves, bark, fruit peels or seed parts.
  • Plants containing proanthocyanidins, especially OPCs are specifically bark of pine, straw, yam, grapes, blueberries, .strawberry, apogado, diseaca, berries or seeds of cowberry, barley, It is contained in wheat, soybeans, black soybeans, cacao, red beans, tochihu hulls, peanut skins, and yew leaves. It is also known that cola nuts in West Africa, Latania roots in Peru, and Japanese green tea contain OPC.
  • the pine bark extract used in the present invention preferably has a high proanthocyanidin content.
  • proanthocyanidins are 30% by mass or more, preferably 50% by mass or more, more preferably 70% by mass or more, more preferably 70% to 99% by mass in terms of dry mass. Is done.
  • OPC is contained in the pine bark extract in terms of dry mass, preferably 30% by mass or more, more preferably 40% by mass or more. Contains 30% by mass or more of OPC Pine bark extract is effective at reducing trauma, especially burns or chemical injury, and promoting recovery even at low concentrations.
  • the pine bark extract preferably contains catechins together with proanthocyanidins (especially OPC), more preferably contains 5% by mass or more of strength catechins, Furthermore, it is particularly preferable that it is contained in an amount of 10% by mass or more because it has an excellent therapeutic effect on burns or burns. '
  • Catechin is a general term for polyhydroxyflavan 1-3-ol.
  • (+) -Epicatechin, (+)-Gallocatechin, (1) -Epigallocatechin, Epigalocatechin gallate, Epi force tekin gallate, etc. are known.
  • (+) —force techin, which is said to be a narrow sense of power, galcatechin, affazerekin, and (+) —3-galloyl derivatives of catechin or gallocatechin are isolated.
  • Catechins have the property of increasing the water solubility in the presence of OPC, and at the same time, activating OPC 1 ", and when ingested with OPC, enhances the action of OPC.
  • the above pine bark extract particularly preferably contains 0.1 part by mass or more of catechins to 1 part by mass of proanthocyanidins. Better! /.
  • the trauma mitigation and recovery promoter of the present invention is characterized by containing the pine bark extract. This trauma alleviation and recovery promoter is administered orally and transdermally. It exhibits excellent trauma mitigation and recovery promoting effects in any administration, and is used, for example, in foods, pharmaceuticals, and quasi drugs.
  • the content of the pine bark extract in the trauma mitigation and recovery promoter of the present invention is not particularly limited.
  • the content of the pine bark extract is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, more preferably 0 in terms of dry mass. , 1 mass. / 0 or more. If you are use for purposes of transdermal administration (e.g., when used as an external preparation), 0 preferably dry weight basis. 0 0 0 1 mass 0/0 or more, preferably 0. 0 0 1 mass% or more, more preferably Is 0.01% by mass or more.
  • the trauma mitigation and recovery promoter of the present invention may contain various additives as required.
  • additives include, for example, additives (excipients, extenders, binders, thickeners (eg, agar)), emulsifiers, lubricants, wetting agents, suspensions that are commonly used by those skilled in the art. Suspensions, colorants (pigments), food ingredients (food additives), seasonings, etc.) or additives usually used in quasi-drugs, cosmetics, and toiletries (base materials, animal and plant extracts, etc.) It is done.
  • the above additives may be used alone or in combination.
  • the additive content is arbitrary.
  • food ingredients include, for example, royal jelly, propolis, vitamins (A, B group, C, D, E,:, folic acid, pantothenic acid, biotin, derivatives thereof, etc.) Mineral ( Iron, magnesium, calcium, dumbbell, etc.), selenium, chitin 'chitosan, lecithin, polyphenol (hydrolyzed tannins such as gallotannin, ellagitannin, catechins, anthocyanins, flavonoids, isoflavones, derivatives thereof, etc.
  • seasoning examples include sweeteners such as granulated honey, honey, and sorbit, acidulants such as alcohol, citrate, malic acid, and tartaric acid, and flavors.
  • a base material such as glycerol, ethanol, paraben, butylene glycol, etc.
  • a base material such as glycerol, ethanol, paraben, butylene glycol, etc.
  • excipients such as dextrin
  • fragrances such as fragrances
  • pigments such as pigments
  • preservatives such as silicone polymers, acrylic polymers, carboxyvinyl polymers
  • chelating agents such as EDTA
  • Refreshing agents such as sucralose, menthol, etc.
  • antiseptic / antifungal agents such as phenoxyethanol
  • the form of the trauma mitigation and recovery promoter of the present invention is not particularly limited.
  • hard capsules, soft It can be formed into a capsule, tablet, pill, or the like, or a powder, granule, bowl or the like. These can be eaten as is, or can be taken by dissolving in water, hot water, milk, etc., or can be taken by leaching the ingredients.
  • a beverage having high functionality or high nutritional value can be obtained by adding it to a plant fermented juice, vegetable juice (for example, carrot juice), plant extract, fruit juice or the like.
  • transdermal administration for example, topical preparations such as cosmetics and toiletries
  • lotion cosmetic cream, emulsion, pack, hair tonic, shampoo, hair rinse, treatment, Body shakes, facial cleansers, stone trials, foundations, lipsticks, hair restorers, ointments, bathing agents, dentifrices, mouthwashes, ships, gels, etc.
  • the dosage of the trauma alleviation and recovery promoter of the present invention is not particularly limited.
  • the intake of pine bark extract is preferably adult (60 kg) — 0.1 mg / day, more preferably 1 mg / day, more preferably 10 mg / day, most preferably 1 Administer at a rate of 0 O mg or more.
  • it is preferably administered at a rate of preferably not more than 200 mg, more preferably not more than 100 mg, and still more preferably not more than 500 mg per adult day.
  • Use Pro Ant Xia two Jin contain (3 0 mass 0 as OPC) 7 0 wt%, a catechin Tsu force 1 0 wt% pine bark extract containing (Toyo new drug) Then, the effect of reducing burns and promoting the recovery were evaluated as follows.
  • One group of rats has 1 mass of pine bark extract. /. Water containing water was allowed to drink freely
  • One group of rats was allowed to freely drink an aqueous solution containing 1% by weight of pine bark extract.
  • the test group contained 0.03 mass of pine bark extract (70 mass% proanthocyanidins, 46 mass% OPC, and 10 mass% force techins, Toyo Shinyaku Co., Ltd.). /.
  • An aqueous solution containing 0.1 mL was applied to the burned area once a day. The burns were visually observed, the number of days required for epithelialization was recorded, and the average value was determined. The results are shown in Table 4. During the period of application of the aqueous solution, rats were given free MF standard feed and water.
  • Eight 8-week-old male Wistar rats (Kudo Co., Ltd.) were fed with MF standard diet (Oriental Yeast Co., Ltd.) and acclimatized for one week. These rats were divided into 2 groups of 4 animals per group and used as the test group and the control group.
  • Eight 8-week-old male Wistar rats (Kudo Co., Ltd.) were fed with MF standard diet (Oriental Yeast Co., Ltd.) and acclimatized for one week. These rats were divided into 2 groups of 4 animals per group, and used as the test group and the control group.
  • the test group contained pine husk extract (70% by mass of proanthocyanidins, 46% by mass of OPC, and 10% by mass of force techins, Toyo Shinyaku Co., Ltd.)
  • An aqueous solution containing mass% was orally administered by gavage once a day so that the dose of pine bark extract was 5 mg / kg body weight.
  • rats were allowed free access to MF standard diet and water.
  • test group was the same as the test group except that water was used instead of the aqueous solution containing the pine bark extract, and the skin condition was scored according to the criteria shown in Table 6 to obtain an average value. The results are also shown in Table 7. Table 6 Table 7
  • the trauma mitigation and recovery promoter of the present invention contains a pine bark extract.
  • This trauma mitigation and recovery promoter can be pre-administered to reduce skin damage due to trauma, especially burns or chemical injury, or administered after skin injury to restore skin damage by regenerating the epidermis. Can be promoted.
  • This Is useful because it can be used as a raw material for oral compositions such as foods and pharmaceuticals, or as a raw material for transdermal compositions such as cosmetics. .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

L’invention concerne un agent pour soulager une plaie et en faciliter la guérison, et contenant un extrait d’écorce de pin. Cet agent pour soulager une plaie et en faciliter la guérison a pour effet de soulager une plaie de la peau due à une lésion (en particulier, une lésion chimique ou par brûlure) et a pour effet d’en faciliter la guérison. De plus, l'agent pour soulager une plaie et en faciliter la guérison ainsi obtenu est utilisable comme matériel pour des compositions orales telles que des aliments et des médicaments de même que comme matériel pour des compositions transdermiques comme des produits de beauté.
PCT/JP2006/314213 2005-07-15 2006-07-12 Agent pour soulager une plaie et en faciliter la guérison WO2007010911A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007526021A JPWO2007010911A1 (ja) 2005-07-15 2006-07-12 外傷の軽減および回復促進剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005206964 2005-07-15
JP2005-206964 2005-07-15

Publications (1)

Publication Number Publication Date
WO2007010911A1 true WO2007010911A1 (fr) 2007-01-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/314213 WO2007010911A1 (fr) 2005-07-15 2006-07-12 Agent pour soulager une plaie et en faciliter la guérison

Country Status (2)

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JP (1) JPWO2007010911A1 (fr)
WO (1) WO2007010911A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010006743A (ja) * 2008-06-26 2010-01-14 Toyo Shinyaku Co Ltd 生体コラーゲン合成促進剤
WO2014104064A1 (fr) * 2012-12-26 2014-07-03 株式会社エーゼット Accélérateur de cicatrisation de plaie

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06336422A (ja) * 1993-05-28 1994-12-06 Kose Corp 皮膚外用剤
JP2001500546A (ja) * 1996-09-04 2001-01-16 バイオティクス、リサーチ、コーポレーション レンズマメ由来の抗酸化剤およびその製法と使用
JP2003146899A (ja) * 2001-11-09 2003-05-21 Toyo Shinyaku:Kk 皮膚改善剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06336422A (ja) * 1993-05-28 1994-12-06 Kose Corp 皮膚外用剤
JP2001500546A (ja) * 1996-09-04 2001-01-16 バイオティクス、リサーチ、コーポレーション レンズマメ由来の抗酸化剤およびその製法と使用
JP2003146899A (ja) * 2001-11-09 2003-05-21 Toyo Shinyaku:Kk 皮膚改善剤

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010006743A (ja) * 2008-06-26 2010-01-14 Toyo Shinyaku Co Ltd 生体コラーゲン合成促進剤
WO2014104064A1 (fr) * 2012-12-26 2014-07-03 株式会社エーゼット Accélérateur de cicatrisation de plaie
CN104936587A (zh) * 2012-12-26 2015-09-23 株式会社Az 创伤愈合促进剂
JPWO2014104064A1 (ja) * 2012-12-26 2017-01-12 株式会社エーゼット 創傷治癒促進剤
US9962364B2 (en) 2012-12-26 2018-05-08 A-Z Ltd. Wound healing accelerator

Also Published As

Publication number Publication date
JPWO2007010911A1 (ja) 2009-01-29

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