WO2006010054A2 - Multivalent vla-4 antagonists comprising polyethylene glycol moieties - Google Patents
Multivalent vla-4 antagonists comprising polyethylene glycol moieties Download PDFInfo
- Publication number
- WO2006010054A2 WO2006010054A2 PCT/US2005/024369 US2005024369W WO2006010054A2 WO 2006010054 A2 WO2006010054 A2 WO 2006010054A2 US 2005024369 W US2005024369 W US 2005024369W WO 2006010054 A2 WO2006010054 A2 WO 2006010054A2
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- WIPO (PCT)
- Prior art keywords
- substituted
- group
- alkyl
- compound
- polymer moiety
- Prior art date
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- 0 CC(CCCN)OCCOCC(COCCO*(C)CCCN)(COC(C)(C)CCOC(C)(C)CCCN)COC(C)(C)CCOC(C)(C)CCN Chemical compound CC(CCCN)OCCOCC(COCCO*(C)CCCN)(COC(C)(C)CCOC(C)(C)CCCN)COC(C)(C)CCOC(C)(C)CCN 0.000 description 6
- GALNSQOAMNTKLL-QFIPXVFZSA-N CCN(CC)c1ncc(CC(F)(F)F)c(N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)n1 Chemical compound CCN(CC)c1ncc(CC(F)(F)F)c(N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)n1 GALNSQOAMNTKLL-QFIPXVFZSA-N 0.000 description 2
- HABHEAFMZLYGJA-UHFFFAOYSA-N CCC(CCN)OCCOC(C)CCOC Chemical compound CCC(CCN)OCCOC(C)CCOC HABHEAFMZLYGJA-UHFFFAOYSA-N 0.000 description 1
- QBDROXBJQBYBTE-QFIPXVFZSA-N CCN(CC)c1nc(N[C@@H](Cc(cc2)ccc2Nc2ncccc2N)C(OC(C)(C)C)=O)c(CC(F)(F)F)cn1 Chemical compound CCN(CC)c1nc(N[C@@H](Cc(cc2)ccc2Nc2ncccc2N)C(OC(C)(C)C)=O)c(CC(F)(F)F)cn1 QBDROXBJQBYBTE-QFIPXVFZSA-N 0.000 description 1
- KKELBJKTLOYBHT-SFHVURJKSA-N CCN(CC)c1ncc(CC(F)(F)F)c(N[C@@H](Cc(cc2)ccc2[N+]([O-])=O)C(OC(C)(C)C)=O)n1 Chemical compound CCN(CC)c1ncc(CC(F)(F)F)c(N[C@@H](Cc(cc2)ccc2[N+]([O-])=O)C(OC(C)(C)C)=O)n1 KKELBJKTLOYBHT-SFHVURJKSA-N 0.000 description 1
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005800298537A CN101035563B (zh) | 2004-07-08 | 2005-07-08 | 包括聚合物部分的多价vla-4拮抗剂 |
BRPI0513143-0A BRPI0513143A (pt) | 2004-07-08 | 2005-07-08 | antagonistas de vla-4 multivalentes compreendendo porções poliméricas |
KR1020077003108A KR101273614B1 (ko) | 2004-07-08 | 2005-07-08 | 중합체 부분을 포함하는 다가 vla―4 길항제 |
AU2005265316A AU2005265316B2 (en) | 2004-07-08 | 2005-07-08 | Multivalent VLA-4 antagonists comprising polymer moieties |
CA2573245A CA2573245C (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polymer moieties |
EP05770402A EP1765412A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
JP2007520561A JP2008505927A (ja) | 2004-07-08 | 2005-07-08 | ポリマー部分を含む多価vla−4拮抗薬 |
MX2007000228A MX2007000228A (es) | 2004-07-08 | 2005-07-08 | Antagonistas de vla-4 multivalentes que comprenden porsiones de polietilenglicol. |
EA200700212A EA012433B1 (ru) | 2004-07-08 | 2005-07-08 | Многовалентные vla-4 антагонисты, содержащие полимерные фрагменты |
IL180558A IL180558A0 (en) | 2004-07-08 | 2007-01-04 | Multivalent vla-4 antagonists comprising polymer moieties |
NO20070216A NO20070216L (no) | 2004-07-08 | 2007-01-12 | Multivalente VLA-1 antagonister inneholdende polymerhalvdeler |
HK08102319.2A HK1111674A1 (en) | 2004-07-08 | 2008-02-29 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
US60/586,975 | 2004-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006010054A2 true WO2006010054A2 (en) | 2006-01-26 |
WO2006010054A3 WO2006010054A3 (en) | 2006-12-28 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Country Status (20)
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006127584A1 (en) * | 2005-05-20 | 2006-11-30 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
WO2007008563A2 (en) * | 2005-07-08 | 2007-01-18 | Elan Pharmaceuticals, Inc. | Preparation of pegylated conjugates of vla-4 antagonists via a mitsunobu' s reaction |
WO2007137260A2 (en) * | 2006-05-22 | 2007-11-29 | Elan Pharmaceuticals, Inc. | Preparation of polymer conjugates of vla-4 antagonists via a mitsunobu' s reaction |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
US7794700B2 (en) | 2004-07-08 | 2010-09-14 | Elan Pharmaceuticals Inc. | Multimeric VLA-4 antagonists comprising polymer moieties |
EP2231185A1 (en) * | 2007-12-07 | 2010-09-29 | Elan Pharmaceuticals Inc. | Methods and compositions for treating liquid tumors |
WO2017015544A1 (en) * | 2015-07-23 | 2017-01-26 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
EP2525831B1 (en) * | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
US11116760B2 (en) | 2018-10-30 | 2021-09-14 | Gilead Sciences, Inc. | Quinoline derivatives |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4754693B2 (ja) * | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
CA2554188A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
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