WO2005123005A1 - Procede et equipement pour la rupture d'une capsule - Google Patents
Procede et equipement pour la rupture d'une capsule Download PDFInfo
- Publication number
- WO2005123005A1 WO2005123005A1 PCT/CN2005/000679 CN2005000679W WO2005123005A1 WO 2005123005 A1 WO2005123005 A1 WO 2005123005A1 CN 2005000679 W CN2005000679 W CN 2005000679W WO 2005123005 A1 WO2005123005 A1 WO 2005123005A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capsule
- pressure
- container
- disassembling
- pressure vessel
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B69/00—Unpacking of articles or materials, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
- B67B7/02—Hand- or power-operated devices for opening closed containers for removing stoppers
- B67B7/04—Cork-screws
- B67B2007/0458—Means for cutting sealing capsules
Definitions
- the invention relates to a method and a device for disassembling a capsule.
- Capsules are more and more widely used in solid preparations because of their many advantages. Capsule filling machines are constantly being improved and developed, and the filling speed of capsule products has been continuously improved. At present, nearly 3,000 pharmaceutical and health care products companies in China produce about 70 billion capsules of capsules each year.
- the average filling rate of capsule products by domestic enterprises is only 95% on average.
- the company will disassemble and recover 5% of the unqualified capsule products.
- the medicines filled in capsules are mainly in the following forms: powder, granules, small tablets, pellets, microcapsules, and a mixture of any two or more of the above.
- all domestic companies use two methods for dismantling and recycling capsules, namely manual disassembly and pulverization. However, both methods have many disadvantages.
- Manual disassembly refers to the use of both hands to pull the capsules one by one.
- the main disadvantages of manual disassembly are:
- the disassembling speed is too slow, it will consume a lot of manpower and time, increase the labor cost, and cannot solve the problem.
- the pulverization method refers to putting a large number of unqualified capsule products into a pulverizer for pulverizing raw materials, and then sieving the powder.
- the main disadvantages of the pulverization method are ⁇
- the product filled with capsules is medicated powder, and after crushing, it will contain a lot of finely divided capsule shell fragments. And it affects the content of effective ingredients of the drug after refilling.
- the object of the present invention is to provide a method and a device for disassembling capsules, which can disassemble the capsules in batches quickly.
- the technical solution of the present invention is: a method for disassembling a capsule, placing a capsule to be disassembled into a pressure vessel; filling the pressure vessel with compressed air, so that high-pressure compressed air passes between the capsule body and the capsule cap The gap inside the capsule enters the capsule; and then the pressure in the pressure vessel is quickly reduced, so that the high-pressure air inside the capsule will expand rapidly due to the sudden pressure difference between the inside and outside.
- a capsule disassembling device includes a container body having a container inner cavity, at least one air inlet channel provided on the container body, an air inlet valve provided on the air inlet channel, and a container body provided on the container body. At least one exhaust passage, and an exhaust valve provided on the exhaust passage.
- the principle of the present invention is to use compressed air to quickly generate a pressure difference between the inside and outside of the capsule, so that the capsule cap can be separated by the pressure inside the capsule, and the medicine filled in the capsule can be separated from the capsule.
- the present invention has the following advantages:
- the capsule separation speed is fast, which is hundreds of times of the manual separation speed, which saves labor costs and can be applied to the recovery of medicines of various capsule products.
- D It is applicable to medicines in all forms of capsules, such as medicine powder, granules, small tablets, pellets, microcapsules, and a mixture of any two or more of the above. It does not damage the integrity of the medicine during recovery, thus avoiding recovery. The re-granulation and tabletting of the medicinal materials can save costs and improve production efficiency.
- the capsule separation rate is high, so the recovery rate of the drug is also high, which effectively avoids the loss of the drug material during the recovery process.
- G. No capsules, shells and other impurities enter during the recovery process of the medicine, which can completely guarantee the purity of the medicine, keep its composition unchanged, and better meet the requirements for the quality of the medicine.
- the drawing is a main sectional view of the structure of a capsule disassembling device
- a method for disassembling a capsule placing the capsule to be disassembled into a pressure vessel; filling the pressure vessel with compressed air, so that the high-pressure compressed air enters the inside of the capsule from the gap between the capsule body and the capsule cap; and then quickly
- the pressure inside the pressure vessel is reduced, so that the high-pressure air inside the capsule will expand rapidly due to the sudden pressure difference between the inside and outside.
- the inside-out expansion force in the capsule will separate the capsule body from the capsule cap.
- the high-pressure compressed air first flattens the capsule in the radial direction and enters the inside of the capsule from the gap between the capsule body and the cap, so that the air pressure inside and outside the capsule gradually reaches equilibrium and is maintained With higher pressure.
- the squashed capsule body and cap are restored to their shape before squeezing by their own elasticity.
- Quickly reducing the pressure in the pressure vessel is to open the air outlet valve on the pressure vessel to discharge high-pressure gas.
- a capsule disassembling device includes a container body 5 having a container inner cavity 6, at least one air inlet passage 4 provided on the container body 5, and an inlet passage provided on the air inlet passage 4.
- the container body 5 is covered with a container cover 9, the container body 5 and the container cover 9 are connected by a hinge on one side, and the container body 5 and the container cover 9 are connected by a buckle 8 on the other side.
- the container body 5 is provided with a pressure gauge 7 for detecting the pressure in the container inner cavity 6.
- a filter sieve 11 for placing the capsule 12 is provided in the inner cavity 6 of the container, and a medicine powder collecting tray 10 is provided below the filter sieve 11.
- the pressure vessel is a pressure vessel made of stainless steel.
- the pressure vessel is tightly sealed and can withstand large internal pressure. It has a material inlet, a compressed air intake channel 4, a compressed air exhaust channel 1, and a pressure gauge. 7 interface. Because the capsule product is filled in an atmosphere of normal pressure, there is more or less atmospheric air inside the capsule except for the drug.
- Capsules to be disassembled 12 Put it in the container cavity 6, close the material inlet and the exhaust channel 1 to seal the container, and fill the compressed air from the air inlet channel 4.
- the compressed air will first flatten the capsule 12 in the radial direction, and compress the air and enter the inside of the capsule from the gap between the carcass and the capsule cap, so that the air pressure inside and outside the capsule 12 gradually reaches equilibrium and maintains a high pressure. At this time, most of the capsule shells that were originally crushed will revert to their original shape by their own elasticity. Then close the air inlet 3, and quickly open the exhaust valve 2, so that the high-pressure air in the inner cavity 6 of the container is discharged instantly. The inner cavity 6 of the container returns to a normal atmospheric pressure state within a very short time. The high-pressure air inside the capsule 1 2 will expand rapidly due to the sudden internal and external pressure difference.
- the expansion force from the inside to the outside of the capsule will separate the capsule from the cap, and the pressure on the capsule wall can be much greater than The force required for capsule separation, so most of the capsule body and cap are completely separated without causing the capsule to "explode", so that the medicine in the capsule can be completely screened out.
- the high-pressure air that originally entered the inside of the capsule 12 will also rapidly expand due to the sudden internal and external pressure difference, so that the capsule shell will return to its original shape. Then, the capsule body and the capsule cap are separated by the expansion force from the inside to the outside.
- the parameters such as the inlet speed, the air pressure in the container, the dwell time in the container, and the exhaust speed can be adjusted to improve the capsule separation rate and drug recovery rate.
Landscapes
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Processing Of Solid Wastes (AREA)
- Working Measures On Existing Buildindgs (AREA)
- Combined Means For Separation Of Solids (AREA)
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005253673A AU2005253673A1 (en) | 2004-06-21 | 2005-05-16 | A method and an equipment for taking apart capsule |
CA002569579A CA2569579A1 (en) | 2004-06-21 | 2005-05-16 | A method for dismantling capsules and an apparatus using thereof |
EP05749706A EP1767181A1 (en) | 2004-06-21 | 2005-05-16 | A method and an equipment for taking apart capsule |
BRPI0512795-5A BRPI0512795A (pt) | 2004-06-21 | 2005-05-16 | metódo para desmanchar capsulas e um aparato para utilizá-lo |
JP2007516944A JP2008503283A (ja) | 2004-06-21 | 2005-05-16 | カプセルの解体方法及びそれに用いる装置 |
US11/630,256 US20070284290A1 (en) | 2004-06-21 | 2005-05-16 | Method for Dismantling Capsules and an Apparatus Using Thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200410041070.8 | 2004-06-21 | ||
CNA2004100410708A CN1593370A (zh) | 2004-06-21 | 2004-06-21 | 胶囊的拆解方法及设备 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005123005A1 true WO2005123005A1 (fr) | 2005-12-29 |
Family
ID=34664873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2005/000679 WO2005123005A1 (fr) | 2004-06-21 | 2005-05-16 | Procede et equipement pour la rupture d'une capsule |
Country Status (9)
Country | Link |
---|---|
US (1) | US20070284290A1 (zh) |
EP (1) | EP1767181A1 (zh) |
JP (1) | JP2008503283A (zh) |
KR (1) | KR20070050910A (zh) |
CN (1) | CN1593370A (zh) |
AU (1) | AU2005253673A1 (zh) |
BR (1) | BRPI0512795A (zh) |
CA (1) | CA2569579A1 (zh) |
WO (1) | WO2005123005A1 (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101288624B (zh) * | 2007-04-20 | 2011-12-21 | 王振林 | 胶囊填充方法及全自动胶囊填充机 |
CN101292939B (zh) * | 2008-05-25 | 2012-08-22 | 韩杰 | 胶囊拆解设备及其控制结构 |
CN102885695B (zh) * | 2008-05-25 | 2014-12-17 | 韩杰 | 胶囊拆解设备 |
PL392412A1 (pl) * | 2010-09-16 | 2012-03-26 | International Tobacco Machinery Poland Spółka Z Ograniczoną Odpowiedzialnością | Sposób ciśnieniowego otwierania paczek |
CN102392718A (zh) * | 2011-10-01 | 2012-03-28 | 韩杰 | 消声器 |
CN103230340A (zh) * | 2012-12-27 | 2013-08-07 | 韩杰 | 一种胶囊拆解设备及胶囊拆解方法 |
CN103231836A (zh) * | 2012-12-27 | 2013-08-07 | 韩杰 | 胶囊拆解设备及胶囊拆解方法 |
CN103110520B (zh) * | 2013-01-27 | 2014-07-16 | 韩杰 | 胶囊拆解设备 |
CN103637913B (zh) * | 2013-12-18 | 2015-04-22 | 翰林航宇(天津)实业有限公司 | 硬胶囊拆壳机 |
CN104528085B (zh) * | 2015-01-01 | 2017-05-17 | 韩杰 | 一种拔囊装置 |
CN104887511A (zh) * | 2015-05-04 | 2015-09-09 | 新昌县航达机械制造有限公司 | 一种次品胶囊分解拆卸装置 |
CN104943923A (zh) * | 2015-05-04 | 2015-09-30 | 新昌县航达机械制造有限公司 | 一种胶囊拆解装置 |
CN105403343B (zh) * | 2015-12-10 | 2018-10-16 | 浙江工业大学 | 胶囊膨胀压的测定装置及其测定方法 |
CN108324573B (zh) * | 2017-01-19 | 2020-07-14 | 张扬 | 一种麻醉科用药物处理装置 |
US11197570B2 (en) * | 2017-03-29 | 2021-12-14 | Greenonyx Ltd | Compact cold-press grinder |
CN114259410A (zh) * | 2021-12-22 | 2022-04-01 | 丁超 | 一种胶囊制备用的脱膜装置 |
CN114735317B (zh) * | 2022-03-17 | 2024-05-03 | 南京佩全超洋科技有限公司 | 一种儿科用可拆分胶囊的取药设备 |
CN116158970B (zh) * | 2023-04-25 | 2023-07-25 | 河北化工医药职业技术学院 | 一种胶囊封装设备 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2080403U (zh) * | 1990-12-12 | 1991-07-10 | 浙江省新昌县药用设备厂 | 自动胶囊切口机 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3609937A (en) * | 1969-09-23 | 1971-10-05 | Estin Hans H | Method for filling capsules |
JPS5829104B2 (ja) * | 1975-12-17 | 1983-06-20 | 三菱油化株式会社 | カプセルノヤクヒンカイシユウホウホウ |
JPS55103856A (en) * | 1979-02-02 | 1980-08-08 | Nikken Chemicals Co Ltd | Method of recovering medicine |
-
2004
- 2004-06-21 CN CNA2004100410708A patent/CN1593370A/zh active Pending
-
2005
- 2005-05-16 JP JP2007516944A patent/JP2008503283A/ja active Pending
- 2005-05-16 EP EP05749706A patent/EP1767181A1/en not_active Withdrawn
- 2005-05-16 CA CA002569579A patent/CA2569579A1/en not_active Abandoned
- 2005-05-16 WO PCT/CN2005/000679 patent/WO2005123005A1/zh active Application Filing
- 2005-05-16 US US11/630,256 patent/US20070284290A1/en not_active Abandoned
- 2005-05-16 BR BRPI0512795-5A patent/BRPI0512795A/pt not_active IP Right Cessation
- 2005-05-16 KR KR1020077000503A patent/KR20070050910A/ko not_active Application Discontinuation
- 2005-05-16 AU AU2005253673A patent/AU2005253673A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN2080403U (zh) * | 1990-12-12 | 1991-07-10 | 浙江省新昌县药用设备厂 | 自动胶囊切口机 |
Also Published As
Publication number | Publication date |
---|---|
US20070284290A1 (en) | 2007-12-13 |
AU2005253673A1 (en) | 2005-12-29 |
KR20070050910A (ko) | 2007-05-16 |
EP1767181A1 (en) | 2007-03-28 |
CA2569579A1 (en) | 2005-12-29 |
BRPI0512795A (pt) | 2008-04-08 |
CN1593370A (zh) | 2005-03-16 |
JP2008503283A (ja) | 2008-02-07 |
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