WO2005058255A1 - Composition permettant d'ameliorer la sante de la peau, des cheveux ou du pelage - Google Patents

Composition permettant d'ameliorer la sante de la peau, des cheveux ou du pelage Download PDF

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Publication number
WO2005058255A1
WO2005058255A1 PCT/EP2004/014416 EP2004014416W WO2005058255A1 WO 2005058255 A1 WO2005058255 A1 WO 2005058255A1 EP 2004014416 W EP2004014416 W EP 2004014416W WO 2005058255 A1 WO2005058255 A1 WO 2005058255A1
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WO
WIPO (PCT)
Prior art keywords
composition
hair
skin
flavanone
coat
Prior art date
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PCT/EP2004/014416
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English (en)
Inventor
Myriam Richelle
Elizabeth Offord-Cavin
Karlheinz Bortlik
Isabelle Bureau-Franz
Gary Williamson
Inge Lise Nielsen
Heike Steiling
Angus Moodycliffe
Original Assignee
Nestec S.A.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34486247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005058255(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2549509A priority Critical patent/CA2549509C/fr
Priority to AU2004298356A priority patent/AU2004298356A1/en
Priority to MXPA06006773A priority patent/MXPA06006773A/es
Priority to ES04804019.0T priority patent/ES2658344T3/es
Priority to EP04804019.0A priority patent/EP1750651B1/fr
Application filed by Nestec S.A. filed Critical Nestec S.A.
Priority to BRPI0417723-1A priority patent/BRPI0417723A/pt
Priority to JP2006544359A priority patent/JP2007514695A/ja
Priority to US10/596,468 priority patent/US9717671B2/en
Publication of WO2005058255A1 publication Critical patent/WO2005058255A1/fr
Priority to NO20063200A priority patent/NO20063200L/no
Priority to ZA2006/05888A priority patent/ZA200605888B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention pertains to a composition for preventing, decreasing and/or treating skin and hair/coat disorders or damages, such as is effected by inflammatory reactions, environmental factors, ageing or cancer.
  • the present invention relates to the use of flavanones compounds or their derivatives in nutritional, cosmetic or pharmaceutical compositions for improvement of human or pet animal skin and coat conditions.
  • the most prominent epithelial tissue in living beings is the skin, which represents the largest organ in the organism.
  • the system of skin integument which comprises the epidermis, dermis and the stratum corneum, correlates with those of internal organs and concurrently interacts with the surroundings. Being the interface between the environment and organism itself, the skin is heavily influenced by external factors and also variable parameters of the organism's inner system.
  • the skin's regulative mechanisms need, therefore, always be active to induce systemic changes necessary to maintain normal pathological events concerning skin integument morphology and activities.
  • EP 0 761 214 discloses singlet oxygen quenchers comprising aniline derivatives and difurfuryl amine derivatives, which are reported to reduce the oxidative stress to the skin.
  • an object of the present invention is to provide compositions that may be used over a long period of time by humans or pets, and susceptible to be provided in the form of a nutritional supplement, for example a nutritional composition.
  • the present invention relates to a nutritional, cosmetic or pharmaceutical composition for human or pets, which contains as active compound, at least one flavanone compound or its derivatives, or a mixture thereof, in an efficient amount to prevent, treat or alleviate skin, hair and/or coat disorders and ameliorate skin, hair and coat health.
  • the invention provides the use of at least one flavanone or its derivatives or mixtures thereof, as active compound in the preparation of a nutritional, cosmetic or pharmaceutical composition intended for preventing or treating skin, hair and/or coat disorders, thus ameliorating skin health conditions in humans or pets.
  • composition according to the present invention may be in the form of a complete nutritional formula, a dietary supplement to be orally administered to a human or an animal, or a compound for pha ⁇ naceutical use.
  • Administering to a human or pet animal, a food composition as described above results in an improved skin health, e.g. on photoprotection, hydration, dryness, firmness, thickness, elasticity, oilness, regular pigmentation, immunity or hair and coat health, e.g. improving hair and coat gloss, hair density, color, oilnes, ameliorating hair fibre diameter, sebum production, glossynes and preventing hair and coat loss.
  • composition according to the present invention is administered to a human or an animal, for ameliorating antioxidant status, barrier function, to prevent or modulate oxidative status, sebum production or composition, or to reduce signs of ageing. It also helps to reduce risks of cancer or inflammation.
  • the invention provides a nutritional, cosmetic or pharmaceutical composition for oral administration for human or pets, which contains as active compound, at least one flavanone compound or its derivatives, or a mixture thereof, in an efficient amount to prevent, treat or alleviate skin, hair and/or coat disorders or damages and thus ameliorate skin, hair and coat health.
  • the flavanone compounds of interest are natural glycosides that can be found principally in fruits from the genus Citrus, such as orange, lemon, bitter orange, grapefruit, for example or in a lesser extend in other vegetables. They are present in majority in the peel of the fruit, but also in large amounts in the pulp and thus also in citrus fruit juice.
  • the compounds according to the present invention may be isosacuranetin, naringin, hesperidin, or eriodictyol, poncirin, neoeriocitrin, for example, and their derivatives selected from their aglycone forms, chalcone forms, glycosylated forms or methylated forms. Also, their sulfated or glucuronidated forms which are found as product of metabolism in blood are used.
  • derivatives may be obtained by several processes known in the art, such as enzymatic treatments.
  • glucose-7-hesperetin is prepared by rhamnosidase or hesperidinase treatment.
  • the flavanone compound or derivatives according to the invention may be included in any composition suitable for administering the substance to an individual, in particular a food composition, a cosmetic composition or a pharmaceutical composition.
  • a food composition for human consumption is prepared.
  • This composition may be a nutritional complete formula, a dairy product, a chilled or shelf stable beverage, soup, a dietary supplement, a meal replacement, and a nutritional bar or a confectionery.
  • the composition may be selected from the group consisting of milk, or fermented milk products, such as e.g. yogurt, curd, cheese, milk based fermented products, ice-creams, milk based powders, infant formulae, cereal products and fermented cereal based products, beverages, mineral water, chocolate or pet food containing at least a flavanone compound or one of its derivatives.
  • the nutritional supplement for oral administration may be in capsules, soft capsules, tablets, pastes or pastilles, gums, or drinkable solutions or emulsions. Methods for preparing them are common knowledge.
  • the nutritional composition may be in the form of a juice of such fruits or in the form of a concentrate.
  • the nutritional composition may be in the form of any food product, in particular any beverage, citrus juice or any other extract from peel or pulp of citrus fruits.
  • a usual food product may be enriched with the flavanones, preferably in the form of citrus extract.
  • a process for preparing an extract enriched if flavanones, in particular hesperidin, from orange and lemon is described in US N02,400,693 and US 2,442,110, respectively.
  • flavanones compounds to be included in the specification may be synthetically produced.
  • a nutritional composition according to the present invention may conprise the flavanone compounds, its derivatives or mixtures thereof in an amount adapted to a daily oral administration, and of from about 0.O1 mg to lg, preferably from about 0.1 mg to 800 mg, more preferably from 10 mg to 8O0 mg of the aglycone equivalent of the flavanone compound.
  • the flavanones according to the invention may be used either alone or in association with other active compounds such as vitamin C, vitamin E (tocopherols and tocotrienols), carotenoids (carotenes, lycopene, lutein, zeaxanthine, beta-cryptoxanthine, etc ..) ubiquinones (e.g.CoQIO), catechins (e.g. epigallocatechin gallate), coffee extracts containing polyphenols and/or diterpenes (e.g. kawheol and cafestol), extracts of chicory, gihkgo biloba extracts, grape or grape seed extracts rich in proanthocyanidins, spice extracts (e.g.
  • active compounds such as vitamin C, vitamin E (tocopherols and tocotrienols), carotenoids (carotenes, lycopene, lutein, zeaxanthine, beta-cryptoxanthine, etc ..)
  • rosemary soy extracts containing isofiavones and related phytoestrogens and other sources of flavonoids with antioxidant activity, fatty acids, e.g. n-3 fatty acids, prebiotic fibers, probiotic microorganisms, taurine, resveratrol, aminoacids, selenium and precursors of gluthathione, for example.
  • compositions can be administered for prophylactic and/or therapeutic treatments.
  • compositions are administered to a patient already suffering from a disease, as described herein under, in an amount sufficient to cure or at least partially arrest the symptoms of the disease and its complications.
  • An amount adequate to accomplish this is defined as "a therapeutically effective dose”. Amounts effective for this will depend on the severity of the disease and the weight and general state of the patient.
  • compositions according to the invention are administered to a patient susceptible to or otherwise at risk of a particular disease. Such an amount is defined to be "a prophylactic effective dose". In this use, the precise amounts again depend on the patient's state of health and weight.
  • the pharmaceutical composition according to the present invention comprises an amount of flavanone compounds, its derivatives or mixture thereof as described above, for a daily administration, from about 0.01 mg to 500 mg.
  • the composition may comprise from 1 mg et 500 mg of the aglycone equivalent of flavanone compounds.
  • the compounds of the invention are preferably administered with a pharmaceutical acceptable carrier, the nature of the carrier differing with the mode of administration, for example parenteral, intravenous, oral and topical (including ophthalmic) routes.
  • the objective substance may also be formulated in a cosmetic product, such as lotions, shampoos, creams, sun-screens, after-sun creams, sun-blocker, anti-ageing creams and/or ointments.
  • a cosmetic product such as lotions, shampoos, creams, sun-screens, after-sun creams, sun-blocker, anti-ageing creams and/or ointments.
  • the present cosmetic products will contain a mixture of different ingredients known to the skilled person, ensuring a fast penetration of the objective substance into the skin and preventing degradation thereof during storage.
  • the compounds according to the present invention may be used for the treatment and/ or prevention of damages in the skin which are produced by a stress situation e.g. by means of a chemical, biological or a physical stress, e.g. by exposure to oxidants or carcinogens, exposure to bacteria, viruses, fungi, lipids derived from surrounding cells and/or microbes, or exposure to UN-irradiation.
  • a stress situation e.g. by means of a chemical, biological or a physical stress, e.g. by exposure to oxidants or carcinogens, exposure to bacteria, viruses, fungi, lipids derived from surrounding cells and/or microbes, or exposure to UN-irradiation.
  • the substances and/or compositions according to the present invention may be utilized for treating and or preventing damages of the skin, in particular actinic and ageing damages of the skin such as dryness, actinic keratoses, irregular pigmentation (notably comprising freckling, lentigines, guttate hypomelanosis and persitent hyperpigmentation), wrinckling (notably comprising fine surface lines and deep furrows), stellate pseudoscars, elastosis, inelasticity, telangiectasia, venous lakes, purpura, comedones, sebaceous hyperplasia, acrochordon, cherry angiogema, seborrhea keratosis, lentigo, basal cell carcinoma and squamous cell carcinoma, skin burning and or blistering, epidermal hyperplasia, inflammation, immune suppression, and cancer, e.g. non-melanoma and melanoma skin cancers. They have also particular benefits on hair and coat, such
  • the effect of a food supplementation in flavanones compounds or its derivatives according to the present invention, on skin of humans or pets, can be measured by using conventional methods including minimal erythemal dose (MED), colorimetry, transepidermal water loss, D ⁇ A repair (e.g.p.53), measure of interleukines and proteoglycans production, or collagenase activity, barrier function or cell renewal.
  • MED minimal erythemal dose
  • colorimetry epidermal water loss
  • D ⁇ A repair e.g.p.53
  • measure of interleukines and proteoglycans production e.g.p.53
  • collagenase activity e activity
  • barrier function or cell renewal e.g.p.53
  • Fig. 1 HaCat cells were incubated with lO ⁇ M hesperetin (hp, red bars) or lO ⁇ M hesperetin-
  • Fig. 2 Chart representing the experimental set-up of the hesperidin growth trial.
  • Fig. 3 Histopathological analysis of rat skin supplementated with hesperidin. 6 ⁇ m paraffin sections were de-waxed, stained with hematoxylin/eosin and mounted. Representative images in two magnifications are shown for the control group (A and D) and the groups supplemented with hesperidin (0.1%: B and E, 0.5% C and F).
  • Fig. 4 Real-time PCR analysis of total RNA isolated from rat skin fed either a control diet (ctrl) or a hesperidin-supplemented diet (0.1% Hp, 0.5% Hp) for the expression of CDldl and interleukin 6 (IL-6). Samples were analyzed in 3 pools containing 4 rats each and obtained Ct values are shown for CDldl in A and IL-6 in B. Dots represent averages of technical triplicates, bars the total average per group. Fold changes in relative expression of the supplementation compared to control diet and relative to a housekeeping gene are shown in C. The control diet was set to 1 fold and is represented by a thick line. Confident intervals were calculated using ANOVA.
  • Example 1 mineral water supplemented with flavanone
  • a mineral water is prepared by adding hesperetin-7-glucose, in an amount of 0.01 mg to 200 mg per liter, estimating that the average consumption is of about 1 liter per day.
  • a composition in the form of a hard capsule has the following formulation:
  • composition can administered to the individual in an amount of 2 to 3 capsules daily.
  • a mixture is prepared from 73 % of poultry carcass, pig lungs and beef liver (ground), 16 % of wheat flour, 7 % of water, 2 % of dyes, flavours, vitamins, and inorganic salts.
  • This mixture is emulsified at 12°C and extruded in the form of a pudding which is then cooked at a temperature of 90°C. It is cooled to 30°C and cut in chunks. 45 % of the chunks are mixed with 55 % of a sauce prepared from 98 % of water, 1 % of dye and 1% of guar gum.
  • Tinplate cans are filled and sterilized at 125° C for 40 min.
  • a food supplement was prepared by mixing or blending fructooligosaccharide with inulin in the proportions by weight of about 70% fructooligosaccharide to about 30% inulin and adding 500 mg of hesperetin equivalent.
  • the resulting prebiotic mixture may be added or blended with any suitable carrier, for example a fermented milk, a yogurt, a fresh cheese, a renneted milk, a confectioneiy bar, breakfast cereal flakes or bars, a drink, milk powder, soy- based product, non-milk fermented product or a nutritional supplement for clinical nutrition.
  • HaCaT Human immortalized keratinocytes
  • lO ⁇ M hesperetin lO ⁇ M hesperetin-7-O-glucuronide or equal amounts of DMSO as a negative control for 16h and lh before challenge.
  • Cells were then treated with lOO ⁇ M menadione, a xenobiotic which generates reactive oxygen species intracellularly.
  • Non-menadione treated cells were used as a positive control.
  • LDH lactate dehydrogenase
  • Rat skin biopsies were obtained from the Heperidin growth trial (Fig.2). Dorsal skin was excised, one part was fixed in 4% PFA and paraffin embedded, one part was cryo-preserved and another part was immediately frozen in liquid nitrogen.
  • Rat skin was dissected and fixed for 4 days in 4% paraformaldehyde in PBS (pH 7.4) at 4°C and embedded in paraffin using a Leica Microsysteme embedding apparatus.
  • the tissues were washed in PBS and saline (0.9% NaCl) and dehydrated by passing them through saline solutions with increasing ethanol concentrations: 30 min each in 30%, 50%, 70%, 90%, 99%, 100%) and an additional hour in 100%.
  • Tissue samples were incubated twice for 30 min in xylene, followed by 2-3 h and 3 h incubations in paraffin wax at 60°C. 6 ⁇ m thick paraffin sections were cut using a Leica Microtome.
  • Sections were de-waxed 5 min in xylene and dehydrated by passing them through a series of solutions with decreasing ethanol concentrations: 1 min each in 100%, 96%, 90%, 80%, 70%, and 50% ethanol. Finally, they were transfe ⁇ ed into destilled water and stained.
  • Rehydrated sections were stained for 45 sec in Mayer's hematoxylin solution, rinsed with the following series of solution for 1 min each: destilled water, tap water, destilled water and 70% ethanol. After staining 10 sec in eosin solution (1% (v/v) in 90% ethanol) sections were rinsed in 90% and 100% ethanol. Following two 10 min incubations in xylene, coverslips were mounted with Eukit and air-dried for 2 h at room temperature.
  • RNA sterile pastic or baked glass vessels (180°C for at least 8h) have been used. All surfaces were cleaned with RNase ZAP prior use, including pipetmen, and aerosol resistant tips were used only.
  • ABI PRISM ® 7000HT Sequence Detection System Applied Biosystems, USA
  • ABI PRISM ® 7000 RT-PCR software Applied Biosystems, USA PCR Cycler, e.g. PTC- 100 Programmable Thermal Controller, MJ Research Inc., USA Agilent 2100 bioanalyzer, Agilent Technologies, USA Fluorescence Plate Reader, e.g. Spectra Fluor Plus F 129005, Tecan, USA Multifi ⁇ ge 3S, Heraeus with special buckets for MFC centrifugation, Kendro Laboratory
  • Cooling Centrifuge e.g. Centrifuge 5417R, Eppendorf, Germany
  • RNA 6000 Nano Assay (Art. No.5065-4475 and 5065-4476), Agilent Technologies, USA Assays-on-demand (20x stock, Applied Biosystems, USA)
  • Milli-Q filtered water (0.22 ⁇ M, ddH 2 0)
  • Ethanol, GR for analysis (Art. No. 02860), Fluka Dulbecco's phosphate buffered saline (PBS, Art. No. D8537), Sigma ⁇ -Mercaptoethanol (Art. No. M7522), Sigma, USA
  • Test ID Assays-on-demand used (Assay ID), including Gene names, genes symbols and reference sequences.
  • the quantification was performed using the Ribogreen ® RNA quantitation Kit on 96-well plates and a fluorescence microplate reader according to the manual. Measurements were done in duplicate. The samples were diluted either 1:680 or 1 :3400 in a final volume of 100 ⁇ l IxTE buffer. Dilutions of the ribosomal RNA in a concentration of 1, 0.5, 0.1, 0.02, 0 ⁇ g/ml were used as standards. Integrity of l ⁇ l RNA was controlled using RNA 6000 Nano Assay.
  • the reverse transcription reaction was performed in a PCR cycler using the following temperature program: activation of the enzyme: lOmin at 25°C; reverse transcription reaction: 60min at 42°C; inhibition of the enzyme: 20min at 70°C. The sample was then kept in the freezer at - 20°C until further use.
  • the PCR reaction was then performed in the ABI PRISM ® 7000 Sequence Detection System using the following temperature program: activation of the enzyme: 2min at 50°C; denaturation: lOmin at 95 °C and 40 cycles target amplification: 15sec annealing at 95°C and lmin extension at 60°C.
  • the analysis of the amplification plots was done using the ABI PRISM ® software Baseline adjustments were done individually (116: 15-25, Cdldl: 10-20, Pcna: 15-25; Gapd: 6-15), whereas thresholds were set manually at 0.2 for all primers.
  • the resulting Ct values were exported into Microsoft Excel for further analysis.
  • hesperidin The protective effect of hesperidin was further investigated in an animal intervential trial using growing femal wistar rats. After weaning, rats were randomized in 3 groups with 12 animals each and supplemented with either a control diet, or a hesperidin supplementated diet using two different doses (0.1% and 0.5%). At the age of 12 weeks rats were sacrificed and skin tissue was used for skin histology and mRNA analysis (Fig. 2). Histopathological analysis of the skin revealed a reduced number of inflammatory cells in animals fed the hesperidin diet. Representative images are shown in Fig. 3 (3A+D (control) vs. 3B+E (0.1% hesperidin) vs. 3C+F (hesperidin)).
  • Rat fed 0.5% hesperidin showed significantly reduced levels of IL-6, an inflammatory cytokine (Fig. 4A+C).
  • CDldl mRNA levels were significantly decreased in both groups supplemented with hesperidin (Fig. 4B+C).

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Abstract

La présente invention se rapporte à une composition permettant d'empêcher, de réduire et/ou de traiter des troubles de la peau et des cheveux ou du pelage, tels que des troubles résultant de réactions inflammatoires, de facteurs environnementaux, du vieillissement ou d'un cancer. En particulier, la présente invention se rapporte à l'utilisation de composés de flavanones ou de leurs dérivés dans des compositions nutritionnelles, cosmétiques ou pharmaceutiques pour l'amélioration de troubles dermatologiques sur un sujet humain ou de troubles du pelage sur un animal domestique.
PCT/EP2004/014416 2003-12-18 2004-12-17 Composition permettant d'ameliorer la sante de la peau, des cheveux ou du pelage WO2005058255A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US10/596,468 US9717671B2 (en) 2003-12-18 2004-12-17 Composition for improving skin, hair and coat health containing flavanones
AU2004298356A AU2004298356A1 (en) 2003-12-18 2004-12-17 Composition for improving skin, hair and coat health containing flavanones
MXPA06006773A MXPA06006773A (es) 2003-12-18 2004-12-17 Composicion para mejorar la salud de la piel, el cabello y el pelo, que contiene flavanonas.
ES04804019.0T ES2658344T3 (es) 2003-12-18 2004-12-17 Composición que contiene flavononas, para la mejora de la salud de la piel y del pelo, y del pelaje
EP04804019.0A EP1750651B1 (fr) 2003-12-18 2004-12-17 Composition contenant des flavanones pour améliorer la santé de la peau et des cheveux des humains et du pelage des animaux
CA2549509A CA2549509C (fr) 2003-12-18 2004-12-17 Composition permettant d'ameliorer la sante de la peau, des cheveux ou du pelage
BRPI0417723-1A BRPI0417723A (pt) 2003-12-18 2004-12-17 composição para melhorar a saúde da pele, cabelo e tegumento contendo flavanonas
JP2006544359A JP2007514695A (ja) 2003-12-18 2004-12-17 フラバノン類を含んでいる皮膚、毛髪及び外皮の健康を改善するための組成物
NO20063200A NO20063200L (no) 2003-12-18 2006-07-10 Preparat for forbedring av hud-, har og pelshelse inneholdende flavanoner
ZA2006/05888A ZA200605888B (en) 2003-12-18 2006-07-17 Composition for improving skin, hair and coat health containing flavanones

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EP03029183.5 2003-12-18

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AR (1) AR047854A1 (fr)
AU (1) AU2004298356A1 (fr)
BR (1) BRPI0417723A (fr)
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ES (1) ES2658344T3 (fr)
MX (1) MXPA06006773A (fr)
NO (1) NO20063200L (fr)
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EP1891967A1 (fr) * 2006-08-24 2008-02-27 Nestec S.A. Composition contenant de flavonoides ayang une longue durée d' absorption
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WO2011126539A3 (fr) * 2010-03-19 2012-03-15 Berry Pharmaceuticals, L.L.C. Compositions et méthodes de traitement de peau de mammifères
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EP2368442A2 (fr) 2005-07-27 2011-09-28 Symrise AG Utilisation d'hespérétine pour améliorer le goût sucré
CN100358427C (zh) * 2005-12-26 2008-01-02 牟海日 一种抗氧化、调血护心、延缓衰老的乳制固体食品或饮料
WO2007112366A3 (fr) * 2006-03-24 2010-09-30 Cella Charles H Enrichissement de produits pour animaux à l'aide de resveratrol
WO2007112366A2 (fr) * 2006-03-24 2007-10-04 Cella Charles H Enrichissement de produits pour animaux à l'aide de resveratrol
AU2007287747B2 (en) * 2006-08-24 2013-11-28 Nestec S.A. Long-lasting absorption of flavonoids
WO2008022784A3 (fr) * 2006-08-24 2008-10-30 Nestec Sa Absorption à long terme de flavonoïdes
EP1891967A1 (fr) * 2006-08-24 2008-02-27 Nestec S.A. Composition contenant de flavonoides ayang une longue durée d' absorption
US8475786B2 (en) 2006-08-24 2013-07-02 Nestec S.A. Long-lasting absorption of flavonoids
EP2078758A2 (fr) 2006-08-24 2009-07-15 Nestec S.A. Absorption de flavonoïdes sur le long terme
WO2008022784A2 (fr) * 2006-08-24 2008-02-28 Nestec S.A. Absorption à long terme de flavonoïdes
JP2010501503A (ja) * 2006-08-24 2010-01-21 ネステク ソシエテ アノニム フラボノイドの持続的吸収
JP2013032366A (ja) * 2007-05-25 2013-02-14 Hayashibara Co Ltd α−グリコシルヘスペリジンを含有する経口投与・摂取用の皮脂量低下抑制剤
US11154731B2 (en) 2007-09-04 2021-10-26 L'oreal Cosmetic use of Bifidobacterium species lysate for the treatment of dryness
WO2009031106A3 (fr) * 2007-09-04 2009-08-06 Oreal Utilisation d'une combinaison d'hespéridine et d'un micro-organisme pour influer sur la fonction de barrière de la peau
EP2082731A1 (fr) 2007-09-04 2009-07-29 L'oreal Utilisation d'une association d'hespéridine et d'un microorganisme pour agir sur la fonction barrière de la peau
FR2920300A1 (fr) * 2007-09-04 2009-03-06 Oreal Utilisation d'une association hesperidine et microorganisme pour agir sur la fonction barriere de la peau.
WO2009031106A2 (fr) * 2007-09-04 2009-03-12 L'oreal Utilisation d'une combinaison d'hespéridine et d'un micro-organisme pour influer sur la fonction de barrière de la peau
FR2920301A1 (fr) * 2007-09-04 2009-03-06 Oreal Utilisation d'une association hesperidine et microogansime pour le traitement de la secheresse des matieres keratiniques.
US10238897B2 (en) 2007-09-04 2019-03-26 L'oreal Use of a lysate of bifidobacterium species for treating sensitive skin
FR2939045A1 (fr) * 2008-12-02 2010-06-04 Daniel Sincholle Compositions pharmaceutiques et nutritionnelles et methode utile pour prevenir et traiter l'inflammation colique et l'endotoxemie metabolique
US8481299B2 (en) 2009-03-04 2013-07-09 L'oreal Use of probiotic microorganisms to limit skin irritation
US9345737B2 (en) 2009-10-14 2016-05-24 Berry Pharmaceuticals, L.L.C. Topical treatment of keratotic lesions using hamelia patens
US8652534B2 (en) 2009-10-14 2014-02-18 Berry Pharmaceuticals, LLC Compositions and methods for treatment of mammalian skin
US9345736B2 (en) 2009-10-14 2016-05-24 Berry Pharmaceuticals, L.L.C. Topical treatment of radiation dermatitis using hamelia patens
WO2011126539A3 (fr) * 2010-03-19 2012-03-15 Berry Pharmaceuticals, L.L.C. Compositions et méthodes de traitement de peau de mammifères
FR2980360A1 (fr) * 2011-09-27 2013-03-29 Oreal Utilisation cosmetique de l'hesperidine ou de l'un de ses derives dans la prevention et/ou le traitement des odeurs corporelles.
CN103826606A (zh) * 2011-09-27 2014-05-28 欧莱雅 橙皮苷或其衍生物在预防和/或治疗体臭中的美容用途
WO2013046141A3 (fr) * 2011-09-27 2013-11-21 L'oreal Utilisation cosmétique de l'hespéridine ou de son dérivé pour la prévention et/ou le traitement des odeurs corporelles
EP2933251A1 (fr) * 2014-04-15 2015-10-21 Weyts, Peter Composition pharmaceutique utilisable pour le traitement d'une pathologie du pied d'un mammifère ongulé
FR3019820A1 (fr) * 2014-04-15 2015-10-16 Peter Weyts Composes de type flavonoides pour leur utilisation dans le traitement d'une pathologie du pied d'un mammifere ongule-composition pharmaceutique associee

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RU2006125735A (ru) 2008-01-27
MXPA06006773A (es) 2006-09-04
CN100553632C (zh) 2009-10-28
ZA200605888B (en) 2008-04-30
KR20060123336A (ko) 2006-12-01
NO20063200L (no) 2006-09-12
ES2658344T3 (es) 2018-03-09
PT1750651T (pt) 2018-02-16
PL380446A1 (pl) 2007-02-05
CN1893909A (zh) 2007-01-10
EP1750651B1 (fr) 2017-11-29
US20070129428A1 (en) 2007-06-07
TW200528134A (en) 2005-09-01
JP2007514695A (ja) 2007-06-07
EP1750651A1 (fr) 2007-02-14
CA2549509A1 (fr) 2005-06-30
AR047854A1 (es) 2006-03-01
RU2355378C2 (ru) 2009-05-20
CA2549509C (fr) 2014-07-22
US9717671B2 (en) 2017-08-01
BRPI0417723A (pt) 2007-04-03
AU2004298356A1 (en) 2005-06-30

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