WO2004110986A1 - ベンズアミド誘導体又はその塩 - Google Patents

ベンズアミド誘導体又はその塩 Download PDF

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Publication number
WO2004110986A1
WO2004110986A1 PCT/JP2004/008479 JP2004008479W WO2004110986A1 WO 2004110986 A1 WO2004110986 A1 WO 2004110986A1 JP 2004008479 W JP2004008479 W JP 2004008479W WO 2004110986 A1 WO2004110986 A1 WO 2004110986A1
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WIPO (PCT)
Prior art keywords
lower alkyl
ring
group
alkylene
monocyclic
Prior art date
Application number
PCT/JP2004/008479
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Takahiro Kuramochi
Norio Asai
Kazuhiro Ikegai
Seijiro Akamatsu
Hironori Harada
Noriko Ishikawa
Shohei Shirakami
Satoshi Miyamoto
Toshihiro Watanabe
Tetsuo Kiso
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Priority to JP2005506991A priority Critical patent/JP4400566B2/ja
Priority to EP04736576.2A priority patent/EP1632477B1/en
Priority to ES04736576.2T priority patent/ES2625341T3/es
Priority to BRPI0411083-8A priority patent/BRPI0411083A/pt
Priority to MXPA05013434A priority patent/MXPA05013434A/es
Priority to US10/560,282 priority patent/US7585878B2/en
Priority to AU2004247559A priority patent/AU2004247559B2/en
Priority to CA002526387A priority patent/CA2526387A1/en
Publication of WO2004110986A1 publication Critical patent/WO2004110986A1/ja
Priority to NO20060167A priority patent/NO20060167L/no
Priority to US12/496,993 priority patent/US7855198B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/04—Ortho-condensed systems
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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072681A2 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain.
WO2006038871A1 (en) * 2004-10-08 2006-04-13 Astrazeneca Ab New hydroxymethylbenzothiazoles amides
WO2007063925A1 (ja) 2005-11-30 2007-06-07 Astellas Pharma Inc. ２－アミノベンズアミド誘導体
WO2007069773A1 (en) * 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
WO2008091021A1 (ja) 2007-01-24 2008-07-31 Mochida Pharmaceutical Co., Ltd. ヘテロシクリデン－ｎ－（アリール）アセトアミド誘導体
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
JP2011500599A (ja) * 2007-10-11 2011-01-06 バーテックス ファーマシューティカルズ インコーポレイテッド 電位開口型ナトリウムチャネルの阻害剤として有用なアミド
US7868181B2 (en) 2006-02-07 2011-01-11 Astrazeneca Ab Compounds
US7910751B2 (en) 2005-07-22 2011-03-22 Mochida Pharmaceutical Co., Ltd. Heterocyclidene acetamide derivative
WO2012008435A1 (ja) * 2010-07-13 2012-01-19 大日本住友製薬株式会社 ビアリールアミド誘導体またはその薬理学的に許容される塩
US8153650B2 (en) 2006-12-26 2012-04-10 Sanofi-Aventis N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
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US8263607B2 (en) 2007-05-22 2012-09-11 Astellas Pharma Inc. 1-substituted tetrahydroisoquinoline compound
JP2013523663A (ja) * 2010-03-30 2013-06-17 ファルメステ ソシエタ ア レスポンサビリタ リミタータ 二環式部分を持つｔｒｐｖ１バニロイド受容体拮抗薬
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US20150025235A1 (en) * 2012-12-21 2015-01-22 Northwestern University Benzamide Compounds and Related Methods of Use
JP2015529673A (ja) * 2012-09-13 2015-10-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ障害の処置のための２−オキソ−２，３−ジヒドロ−インドール
US9328096B2 (en) 2014-05-07 2016-05-03 Pfizer Inc. Tropomyosin-related kinase inhibitors
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Publication number Priority date Publication date Assignee Title
KR20060027338A (ko) 2003-06-12 2006-03-27 아스텔라스세이야쿠 가부시키가이샤 벤즈 아미드 유도체 또는 그 염
ES2580108T3 (es) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
TWI383987B (zh) * 2005-11-21 2013-02-01 Anadys Pharmaceuticals Inc 製備５-胺基-３Ｈ-噻唑并〔４，５-ｄ〕嘧啶-２-酮之新穎方法
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AU2018351714A1 (en) 2017-10-16 2020-04-30 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN115304457A (zh) * 2021-05-07 2022-11-08 中国科学院上海有机化学研究所 一种联二萘骨架的环戊二烯铑络合物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
WO2002008221A2 (en) * 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
JP2003055209A (ja) * 2001-07-31 2003-02-26 Bayer Ag フェニルナフチル尿素誘導体
WO2003055848A2 (en) * 2001-12-26 2003-07-10 Bayer Healthcare Ag Urea derivatives as vr1- antagonists
WO2003068749A1 (en) * 2002-02-15 2003-08-21 Glaxo Group Limited Vanilloid receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9709906A (pt) 1996-06-17 1999-08-10 Smithkline Beecham Plc Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes
US20010016657A1 (en) 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
CN1183116C (zh) 1997-03-18 2005-01-05 史密丝克莱恩比彻姆有限公司 取代的异喹啉类衍生物、含有它们的药物组合物、其制备方法及用途
AU7315700A (en) 1999-09-20 2001-04-24 Takeda Chemical Industries Ltd. Melanin concentrating hormone antagonist
CA2455754A1 (en) 2001-07-31 2003-02-20 Bayer Healthcare Ag Amine derivatives
SK2242004A3 (en) 2001-10-25 2004-11-03 Takeda Chemical Industries Ltd Quinoline compound
AU2003295609A1 (en) * 2002-11-15 2004-06-15 University Of Utah Integral titanium boride coatings on titanium surfaces and associated methods
AU2003299797A1 (en) 2002-12-19 2004-07-14 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
ATE450533T1 (de) 2003-02-14 2009-12-15 Glaxo Group Ltd Carboxamidderivate
US20050004133A1 (en) 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
KR20060027338A (ko) 2003-06-12 2006-03-27 아스텔라스세이야쿠 가부시키가이샤 벤즈 아미드 유도체 또는 그 염
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
WO2002008221A2 (en) * 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
JP2003055209A (ja) * 2001-07-31 2003-02-26 Bayer Ag フェニルナフチル尿素誘導体
WO2003055848A2 (en) * 2001-12-26 2003-07-10 Bayer Healthcare Ag Urea derivatives as vr1- antagonists
WO2003068749A1 (en) * 2002-02-15 2003-08-21 Glaxo Group Limited Vanilloid receptor modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1632477A4 *

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2005072681A3 (en) * 2004-01-23 2005-09-22 Amgen Inc Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain.
WO2005072681A2 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain.
JP2007518816A (ja) * 2004-01-23 2007-07-12 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び炎症性及び神経因性疼痛の治療におけるこれらの使用
WO2006038871A1 (en) * 2004-10-08 2006-04-13 Astrazeneca Ab New hydroxymethylbenzothiazoles amides
US8383839B2 (en) 2005-07-22 2013-02-26 Mochida Pharmaceutical Co., Ltd. Heterocyclidene acetamide derivative
US7910751B2 (en) 2005-07-22 2011-03-22 Mochida Pharmaceutical Co., Ltd. Heterocyclidene acetamide derivative
US8106190B2 (en) 2005-11-30 2012-01-31 Astellas Pharma Inc. 2-aminobenzamide derivatives
EP1955697A4 (en) * 2005-11-30 2011-01-26 Astellas Pharma Inc 2-AMINOBENZAMIDE DERIVATIVE
WO2007063925A1 (ja) 2005-11-30 2007-06-07 Astellas Pharma Inc. ２－アミノベンズアミド誘導体
WO2007069773A1 (en) * 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
AU2006329879B2 (en) * 2005-12-16 2012-06-21 Infinity Discovery, Inc. Compounds and methods for inhibiting the interaction of Bcl proteins with binding partners
US7868181B2 (en) 2006-02-07 2011-01-11 Astrazeneca Ab Compounds
US8716272B2 (en) 2006-12-26 2014-05-06 Sanofi N-(amino-heteroaryI)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
US8153650B2 (en) 2006-12-26 2012-04-10 Sanofi-Aventis N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
US8716273B2 (en) 2006-12-26 2014-05-06 Sanofi N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy
WO2008091021A1 (ja) 2007-01-24 2008-07-31 Mochida Pharmaceutical Co., Ltd. ヘテロシクリデン－ｎ－（アリール）アセトアミド誘導体
US8263607B2 (en) 2007-05-22 2012-09-11 Astellas Pharma Inc. 1-substituted tetrahydroisoquinoline compound
JP2011500599A (ja) * 2007-10-11 2011-01-06 バーテックス ファーマシューティカルズ インコーポレイテッド 電位開口型ナトリウムチャネルの阻害剤として有用なアミド
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
JP2013523663A (ja) * 2010-03-30 2013-06-17 ファルメステ ソシエタ ア レスポンサビリタ リミタータ 二環式部分を持つｔｒｐｖ１バニロイド受容体拮抗薬
WO2012008435A1 (ja) * 2010-07-13 2012-01-19 大日本住友製薬株式会社 ビアリールアミド誘導体またはその薬理学的に許容される塩
JP2015529673A (ja) * 2012-09-13 2015-10-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ障害の処置のための２−オキソ−２，３−ジヒドロ−インドール
US20150025235A1 (en) * 2012-12-21 2015-01-22 Northwestern University Benzamide Compounds and Related Methods of Use
US9533947B2 (en) * 2012-12-21 2017-01-03 Northwestern University Benzamide compounds and related methods of use
US9890117B2 (en) 2012-12-21 2018-02-13 Northwestern University Benzamide compounds and related methods of use
US9328096B2 (en) 2014-05-07 2016-05-03 Pfizer Inc. Tropomyosin-related kinase inhibitors
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

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MXPA05013434A (es) 2006-03-17
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US7855198B2 (en) 2010-12-21
US20070167444A1 (en) 2007-07-19
BRPI0411083A (pt) 2006-07-25
EP1632477A4 (en) 2008-07-16
AU2004247559A1 (en) 2004-12-23
US20090270365A1 (en) 2009-10-29
PT1632477T (pt) 2017-04-04
EP1632477A1 (en) 2006-03-08
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