WO2004052747A1 - Procede d'inspection de matiere etrangere - Google Patents

Procede d'inspection de matiere etrangere Download PDF

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Publication number
WO2004052747A1
WO2004052747A1 PCT/JP2003/015700 JP0315700W WO2004052747A1 WO 2004052747 A1 WO2004052747 A1 WO 2004052747A1 JP 0315700 W JP0315700 W JP 0315700W WO 2004052747 A1 WO2004052747 A1 WO 2004052747A1
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WO
WIPO (PCT)
Prior art keywords
printing layer
package according
foreign matter
package
container
Prior art date
Application number
PCT/JP2003/015700
Other languages
English (en)
Japanese (ja)
Other versions
WO2004052747A8 (fr
Inventor
Yukihiro Taguchi
Original Assignee
Ckd Corporation
Toyo Aluminium Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ckd Corporation, Toyo Aluminium Kabushiki Kaisha filed Critical Ckd Corporation
Priority to AU2003289255A priority Critical patent/AU2003289255A1/en
Publication of WO2004052747A1 publication Critical patent/WO2004052747A1/fr
Publication of WO2004052747A8 publication Critical patent/WO2004052747A8/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/40—Applications of laminates for particular packaging purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/30—Printed labels

Definitions

  • the present invention relates to a novel package and a foreign matter inspection method.
  • a press-through pack (PTP) package is leaking as a package for containing drugs (eg, tablets, capsules).
  • PTP packaging is transparent or half-printed
  • Japanese Patent Application Laid-Open No. H11-39484 describes that a video signal obtained by using a PTP sheet by a CCD camera or the like is processed in a specific manner, so that a mesh pattern is formed on the entire inspection object.
  • a defect detection method has been proposed that can easily detect foreign matter without depending on lighting technology.
  • the printed portion cannot be distinguished from the foreign matter.
  • the main object of the present invention is to more reliably inspect foreign substances even if they have a printed layer. And a method for inspecting foreign matter therefor.
  • the present inventor has conducted intensive studies in view of the above-mentioned problems of the prior art, and as a result, has found that a package formed with a specific printing layer can achieve the above object, and has completed the present invention. .
  • the present invention relates to the following package and foreign matter inspection method.
  • the container is obtained by molding a transparent or translucent resin film;
  • the lid material includes at least one of an aluminum-based material, a resin film, and paper;
  • a printing layer is formed on part or all of the surface of the lid member on the side that closes the opening, and (d) the printing layer contains at least two types of coloring materials including pigments and dyes.
  • the printed layer contains the dye pump rack and titanium or titanium oxide as a coloring material, the dye black content is 10% by weight or less in the print layer, and the titanium oxide content is printed.
  • Item 6. The package according to any one of Items 1 to 5, wherein the amount of the package is 60% by weight or less in the layer.
  • the printing layer contains ferric oxide and Z or phthalocyanine green as a colorant, and the total content of ferric oxide and phthalocyanine green in the printing layer is 6%.
  • Item 6. The package according to any one of Items 1 to 5, which is 0% by weight or less.
  • a foreign matter inspection method having a step of determining the presence or absence of a foreign matter in the above.
  • the package of the present invention is a package in which contents are loaded into a container having an opening, and the opening is closed by a lid material,
  • the container is obtained by molding a transparent or translucent resin film;
  • the lid material includes at least one of an aluminum-based material, a resin film, and paper;
  • a printed layer is formed on part or all of the surface of the lid member on the side that closes the opening, and
  • the printed layer contains at least two types of coloring materials including pigments and dyes. It is characterized.
  • the container used in the package of the present invention may be any one obtained by molding a transparent or translucent resin film, and if the material, shape, molding method, etc. are appropriately selected according to the type of the contents, etc. good.
  • a resin film having a plurality of pockets can be used.
  • the material for example, vinyl chloride, polypropylene and the like are preferable.
  • resin The thickness of the lum is not limited, but is preferably about 0.05 to 2 mm.
  • This container can be formed by, for example, a method using a press machine (extension forming, deep drawing forming, etc.) or a method not using a press machine (vacuum forming, pressure forming, etc.). These formings may be either cold forming or hot forming, or may use both together.
  • the lid material may be any material that includes at least one of an aluminum-based material, a resin film, and paper.
  • an aluminum-based material alone or a laminate of a paper layer, a resin film layer, and the like on an aluminum-based material may be used. Further, it may be formed of a resin film alone or paper alone, or may be a laminate obtained by combining these with other materials. If necessary, an anchor coat layer, a printing layer, a coloring layer, a primer layer, an overcoat layer and the like may be appropriately formed.
  • the aluminum-based material may be either aluminum or an aluminum-based alloy.
  • pure aluminum JIS (AA) 1000 system, for example, 1N30, 1N700, etc.
  • A1 Mn system JIS (AA) 300 system, for example, 300, 304, etc.
  • A1-Mg system JIS (AA) 50,000 system
  • A1-Fe system JIS (AA) 8000 system, for example, 8 0 2 1, 8 0 7 9 etc.
  • Components such as Fe, Si, Cu, Ni, Cr, Ti, Zr, Zn, Mn, Mg, and Ga contained in aluminum materials are specified in JIS, etc. It does not matter if the content is within the known range.
  • the aluminum-based material is desirably used in the form of a foil (sheet).
  • the thickness is preferably 7 to 50 zm, particularly preferably 10 to 40 m.
  • moisture resistance moisture resistance
  • any of a hard material, a semi-hard material, and a soft material may be used, and may be appropriately selected according to the shape of the container, the type of the contents, and the like.
  • the aluminum foil can be subjected to molding, degreasing, washing, anchor coating, overcoating, surface treatment, and the like, if necessary, by a known method. By using aluminum foil, strength as a packaging material, Barrier properties, preservability, etc. can be exhibited effectively.
  • the thickness of the paper layer is preferably about 10 to L 0 m.
  • polyamide nylon
  • polyethylene especially high-density polyethylene
  • polypropylene especially stretched polypropylene
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate polyethylene terephthalate
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate polyethylene terephthalate
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate polyethylene terephthalate
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate especially polyethylene terephthalate
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate especially stretched polypropylene
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate especially stretched polypropylene
  • vinyl chloride ethylene-bier alcohol copolymer
  • polyethylene naphtholate especially stretched polypropylene
  • vinyl chloride ethylene-bier alcohol cop
  • the method for laminating or bonding each layer is not particularly limited, and a known method can be applied.
  • a dry lamination method using a two-component curable urethane-based adhesive such as a polyester urethane-based or polyester-based adhesive, a co-extrusion method, an extrusion coating method, and a thermal lamination method using an anchor coating agent can be used.
  • a part of the surface (front surface) of the lid on the side that closes the opening of the container in other words, the side that is joined to the opening with or without the adhesive layer).
  • a printing layer is formed on all of them.
  • the printing layer may be formed at a portion joined to the container opening with or without the adhesive layer interposed therebetween, or may be formed at a portion other than the portion.
  • a print layer may be provided on the surface (the back surface) opposite to the above surface, if necessary.
  • These printing layers may be a single layer or a multilayer consisting of two or more layers.
  • the printing layer contains two or more kinds of coloring materials consisting of pigments and dyes.
  • pigments and dyes include known inorganic pigments (e.g., barium sulfate, zinc white, iron black, yellow iron oxide, ultramarine, navy blue, talc, calcium carbonate, cobalt curry, benkara etc.), organic pigments (e.g., monoazo-based pigments).
  • the printing layer is preferably a layer that does not absorb infrared rays. As a result, it is possible to obtain more excellent foreign substance detection accuracy in the foreign substance inspection using infrared light.
  • does not absorb infrared light means that the printed layer formed on the cover material does not absorb infrared light at all, or that it absorbs infrared light within a range that does not hinder the inspection of foreign substances or absorbs infrared light. The case where light is transmitted is also included.
  • the printed layer formed on the cover material reflects near infrared rays by 50% or more. Further, it is more preferable that the printed layer formed on the lid material reflects near infrared rays having a wavelength of 800 to 900 nm by 50% or more (especially 65% or more). By having the infrared reflection characteristic, it is possible to achieve higher foreign object detection accuracy.
  • the colorant which does not absorb infrared rays accounts for 70% by weight or more, particularly 80% by weight or more of the total colorant.
  • coloring materials that do not absorb infrared rays include disazoiello, phthalocyanine blue, dioxazine, virazolo orange, naphthol AS, oxinaphthoic acid, barium salt, soluble azo, perylene black and It is preferable to use two or more pigments of aniline black.
  • pigments that can be used in the printing layer of the present invention.
  • the printing layer contains ferric oxide and Z or phthalocyanine daline as a coloring material
  • the total content of ferric oxide and phthalocyanine green is not more than 60% by weight in the printing layer. Is preferable, and the effects of the present invention can be effectively exhibited.
  • the printing layer prepare an ink containing the coloring material as described above, and apply this on the lid material. What is necessary is just to form by doing.
  • the ink for example, an ink containing the coloring material, binder and solvent can be suitably used.
  • the above-mentioned coloring materials can be used as described above, and the content thereof is not limited, but it is generally preferably about 1 to 30% by weight, particularly preferably 3 to 15% by weight in the ink.
  • carbon black, carbon, or titanium oxide can be used as a coloring material, if necessary.
  • carbon black, carbon, or titanium oxide it is preferable to adjust the amount of carbon black used so as to be 10% by weight or less in the print layer.
  • the amount of titanium oxide used is preferably adjusted so as to be 60% by weight or less in the printed layer.
  • the binder is not particularly limited, and examples thereof include nitrocellulose, polyvinyl butyral, phenolic resin, maleic acid resin, alkyd resin, and acrylic resin. These can be used alone or in combination of two or more.
  • the content of the binder is preferably about 5 to 30% by weight in the ink.
  • Solvents are not limited and include, for example, toluene, xylene, methyl edel ketone, isopropyl alcohol, thinner, ethyl acetate, methyl acetate, butylacetosolve, butyl acetate, methanol, ethanol, butanol, hexane, acetone. Etc. can be used. These can be used alone or in combination of two or more. The amount of the solvent used may constitute the balance of the ink.
  • rosin diethylene glycol, amine, linseed oil, castor oil, stearic acid, oleic acid, etc., as necessary, as well as dispersants, hardeners, anti-settling agents, softeners, antioxidants, constitution Pigments, UV absorbers, leveling agents, surface conditioners, anti-sagging agents, thickeners, defoamers, lubricants, etc. may be added.
  • the forming method is not particularly limited, and for example, a known printing method can be applied. For example, letterpress printing, intaglio printing, screen printing, offset printing, gravure printing, and the like can be applied.
  • a drying step For example, by setting the condition from room temperature (20 ° C) to about 250 ° C for about 10 seconds to 10 hours, Can be dried. When drying continuously, it may be designed so that it can be dried by blowing hot air or move in an oven.
  • the color of the print layer is not limited, but it is desirable that the print layer exhibit a black or brown color from the viewpoint of visibility and the like.
  • a mixed pigment composed of three kinds of pigments: a red pigment (for example, barium salt), a yellow pigment (for example, diazoiellone), and a blue pigment (for example, phthalocyanine blue). preferable.
  • the thickness of the printing layer is not limited, but is preferably 0.1 to about L 0 / m.
  • the weight of the printing layer (weight after drying) is 0. It is preferable to 1 ⁇ 1 O gZm 2 about.
  • the container opening is closed by the lid material.
  • This method is not particularly limited, and a known method can be applied. For example, there is a method using an adhesive.
  • heat-adhesive resin examples include high-density polyethylene, medium-density polyethylene, low-density polyethylene, linear linear polyethylene, saturated polyester, linear saturated polyester, undrawn polypropylene, chlorinated polypropylene, ethylene-acrylic acid copolymer, ethylene-methacrylic acid Copolymer, ethylene-ethyl acrylate copolymer, ethylene-methyl acrylate copolymer, ionomer, ethylene-ethyl acrylate-maleic anhydride terpolymer, polyolefin, carboxylic acid modified Examples include polyethylene, carboxylic acid-modified polypropylene, carboxylic acid-modified ethylene-viel acetate, vinyl chloride, and polystyrene. Also, commercially available products such as “Bondane” manufactured by Sumitomo Chemical Co., Ltd. and “Mersen M” manufactured by Tosoh Corporation can be used. One or more of
  • the thermal bonding layer may be formed on at least one of the lid and the container, but is particularly preferably formed on the lid.
  • the heat bonding layer is formed by applying a liquid adhesive containing the above resin or laminating a heat bonding film made of the above resin. be able to.
  • the thickness of the heat bonding layer is not limited, it is usually preferable to be about 2 to about L00 m.
  • the conditions for heat sealing can be changed as appropriate depending on the type of thermal adhesive to be used, the type of contents, and the like, but generally it is sufficient to set the temperature at 140 to 260 ° C for about 1 to 3 seconds.
  • a ring seal also referred to as a “line seal”
  • a mesh seal can be applied.
  • an ultrasonic seal, an induction heat seal, or the like can be adopted.
  • the contents to be loaded into the container of the package of the present invention are not particularly limited, and the contents filled and loaded into a known PTP package can be applied as they are. It is desirable that the contents be solid. Examples include pharmaceuticals (pharmaceuticals), foods, electronic components, contact lenses, fragrances, detergents, and the like. In particular, it is suitable for drugs that require foreign substance inspection. Further, the drug may be any of tablets, capsules and the like.
  • the contents may be printed (sealed) as necessary. In this case, the print is desirably a print layer that does not absorb infrared rays. As such a printing layer, the same one as described above can be employed.
  • the package of the present invention can be applied to foreign matter inspection using infrared light. More specifically, it can be suitably used in the foreign matter inspection method of the present invention described later. By applying the package of the present invention to the above-described inspection method, it is possible to detect foreign substances with high accuracy.
  • FIG. 1 shows a schematic view of the package of the present invention.
  • Aluminum foil is used as the cover material (1), and a printed layer (3) is formed on the surface (6) of the cover material that is joined to the transparent container (2) via the thermal adhesive layer (5). .
  • the transparent container is loaded with tablets (4) as contents. Then, the lid member and the transparent container are joined by a heat seal via the heat bonding layer (5), and the opening of the transparent container is closed by the lid member.
  • a package is obtained in which the print layer is formed on part or all of the surface (6) of the lid on the side that closes the opening. 2.
  • the foreign matter inspection method of the present invention is a foreign matter inspection method of the package of the present invention
  • At least (1) the contents, (2) the container, and (3) the surface of the lid that closes the opening of the container is irradiated with light including infrared light.
  • light including infrared light light including infrared light and light in a wavelength region other than infrared light (eg, visible light) can be used.
  • the irradiation time, irradiation area, intensity, and the like of light including infrared light can be appropriately adjusted according to the type of the contents.
  • a known device can be used as the device for irradiating light.
  • an area irradiated with light including infrared light is imaged.
  • the imaging means include a camera having sensitivity only to infrared light, and a camera having sensitivity to infrared light provided with a filter that transmits only infrared light. These may be known or commercially available ones. For example, a commercially available CCD camera or the like can be used.
  • the presence or absence of a foreign substance in the area is determined from the image data obtained by the imaging.
  • the determination method is not particularly limited as long as it is a method that can detect a foreign substance in distinction from the print layer.
  • the following approach can be taken.
  • the image data obtained by the imaging means having sensitivity to infrared light the brightness of the contents is higher than the brightness of the container (resin film) regardless of the color of the contents.
  • the brightness of foreign matter on the contents, cracks and chipping of the contents is lower than the brightness of the contents, and the brightness of the foreign substances on the resin film is lower than the brightness of the resin film.
  • the printing layer is a layer that does not absorb infrared rays, the difference in brightness between the printing layer and the resin film is extremely small.
  • the image having the difference in brightness may be processed by means as shown in FIG.
  • FIG. 2 shows the configuration of the image processing device (23).
  • This device (means) includes an AZD converter (27), shading correction means (28), first binarization means (29), first image memory (30), second binarization means (31 ), Second image memory (32), judgment memory (34), CPU and input / output interface (35), third image memory (33), visual inspection result and statistical data memory (36), It consists of camera timing control means (37).
  • the AZD converter (27) converts a two-dimensional image captured by a CCD camera (22) as an imaging means from an analog signal to a digital signal.
  • the converted image data is subjected to shading correction by the shading correction means (28) according to the data of the shading correction table (38), and then stored in the third image memory (33).
  • the shading correction is performed, if it is difficult to uniformly irradiate the entire imaging area of the resin film with light including infrared light, if necessary. Can be done to correct
  • the data relating to the corrected brightness is binarized by the first binarizing means (29) with the first threshold value ⁇ 1, and is sequentially stored in the first image memory (30). Thereby, first binary image data of the resin film is formed.
  • the first threshold value ⁇ ⁇ ⁇ ⁇ is used to determine a foreign substance in the area where the content exists (content area).
  • the first threshold value ⁇ for example, a value that is lighter than the resin film and the foreign material serving as the background of the content and a value that is darker than the content is selected.
  • the first threshold value 01 is preferably set to a value slightly lower than the brightness of the contents.
  • the corrected data relating to the brightness is binarized by the second binarization means (31) with the second threshold value 02, and then stored in the second image memory (32). Thereby, the second binary image data of the resin film is formed.
  • the second threshold value ⁇ 52 is mainly for determining foreign substances present in the resin film.
  • the second threshold value ⁇ 2 a value darker than the resin film and the printing layer is selected.
  • the second threshold value ⁇ 2 is preferably set to a value slightly lower than the brightness of the resin film.
  • the CPU and the input / output interface (35) execute programs such as various image processing programs while using the contents of the memory for judgment (34) and send control signals to the PTP packaging machine (11). It is for sending out or receiving various signals such as operation signals from the PTP packaging machine (11). This makes it possible to control, for example, a defective sheet discharging mechanism of the PTP packaging machine (11). Further, the CPU and the input / output interface (35) have a function of transmitting display data to the monitor (24). With this function, it is possible to display on a monitor (24) a binary or shaded image, a visual inspection result, and the like.
  • the visual inspection result and statistical data memory (36) stores data such as coordinates relating to the image data, visual inspection result data, statistical data obtained by statistically processing the visual inspection result data, and the like. These data can be displayed on the monitor (24) based on the control of the CPU and the input / output interface (35). Also, based on these data, the CPU and input / output interface (35) can send control signals to the PTP packaging machine (11).
  • the keyboard (25) is used to input settings such as reference values for pass / fail judgment stored in the judgment memory (34).
  • the camera timing control means (37) controls the timing at which image data captured by the CCD camera (22) is taken into the AZD converter (27). This timing is controlled based on a signal from an encoder (not shown) provided in the PTP packaging machine (11), and an image is taken by the CCD camera (22) every time a predetermined amount of resin film is sent. Be done.
  • Fig. 3 (a) shows the appearance inspection range of a resin film (PTP film) as a specific example. Part of the box (this inspection area is indicated as “P”). The container (pocket) formed by molding the PTP film contains as the contents. The letter “C” is stamped on this lj, and it is assumed that foreign matter Dx is attached. It is assumed that the character “123” is printed on the cover film serving as the cover material, and that the foreign matter Dy is attached.
  • the PTP film is imaged by a CCD camera, corrected for shading, and stored in a third image memory (33).
  • the brightness of the stored image on the line AA ′ in FIG. 3 (a) is high in the content area ( ⁇ area) as shown in FIG. 3 (b), and the area of the cover film and the foreign substance area are high. Becomes lower.
  • routine R1 is executed according to the flowchart shown in FIG.
  • “the inspection determination accompanying the first binarization process” is executed by the image processing device (23) (mainly the CPU).
  • the image processing device (23) forms first binary image data by the first binary image forming means (29), and stores this data in the first image memory.
  • the dimensional image is converted to binary image data as shown in Fig. 3 (d).
  • step S2 block processing is performed on the first binarized image data stored in the first image memory (30).
  • the lump processing includes processing to identify each connected component for 0 ( ⁇ ) and 1 (bright) in the binarized image data, and label processing for labeling each connected component.
  • the occupied area of each specified connected component is represented by the number of dots corresponding to the pixel of the CCD camera (22).
  • step S3 the image processing device (23) selects, from among the 1 (bright) connected components obtained from the first binarized image, the connected component corresponding to the tablet having the above-mentioned seal.
  • a connected component corresponding to a tablet can be easily determined by a determination method of a connected component including predetermined coordinates, a connected component having a predetermined shape, a connected component having a predetermined area, or the like. That is, the tablet area) can be specified. Therefore, in this inspection area P, the tablet area J containing the foreign matter Dx (Fig. 3 (See (d)).
  • step S4 the image processing device (23) calculates the area Sx of the foreign substance in the tablet area. That is, among the 0 (dark) connected components obtained from the first binary image, the one included in or connected to the coordinates of the tablet region specified in step S3 is extracted, and its area Sx Ask for. Therefore, in the inspection range P, the area of the foreign matter Dx is calculated.
  • step S5 the area S X of the foreign matter is compared with a predetermined criterion value P. If the area Sx of the foreign matter is smaller than the determination reference value Px, the process proceeds to step S6, and a non-foreign matter determination (normality determination) is performed. Therefore, in the inspection range P, it is determined whether or not the foreign matter Dx is a foreign matter by comparing the area of the foreign matter Dx with the determination reference value Px. As described above, in the routine R1, the presence / absence of a foreign substance in the tablet area is determined, regardless of the presence / absence of the stamped part, after specifying the eyelet area.
  • FIG. 5 is a flowchart showing the routine R2.
  • step S11 the image processing device (23) creates second binary image data by the second binarizing means (31), and stores this data in the second image memory. (32).
  • the second threshold value ⁇ 52 is 1 (bright) and the second threshold value ⁇ 52 is 0 (dark)
  • the data on the line A-A ' The two-dimensional image is converted to binary image data as shown in Fig. 3 (f).
  • step S12 the same block processing as in step S2 is performed on the second binarized image data stored in the second image memory (32).
  • step S13 the image processing device (23) calculates the area Sy of the foreign matter Dy. That is, a connected component of 0 (dark) obtained from the second binary image data is extracted and its area Sy is obtained. Therefore, in the inspection range P, the area Sy of the foreign matter Dy is calculated.
  • step S14 the area Sy of the foreign object is compared with a predetermined determination reference value Py. If the area Sy of the foreign matter is smaller than the determination reference value Py, the process proceeds to step S15, and a non-foreign matter determination (normal determination) is performed. On the other hand, the area Sy If the value is equal to or greater than the fixed reference value Py, the process proceeds to step 16 and a foreign object determination (abnormality determination) is performed in step 16. Therefore, in the inspection range P, the area of the foreign matter Dy is compared with the determination reference value Py to determine whether the foreign matter Dy is a foreign matter. As described above, in the routine R2, it is mainly determined whether or not there is a foreign substance on the cover film regardless of the presence or absence of the print layer.
  • the processing of the above routines R1 and R2 is executed in the process of manufacturing (pharmaceutical packaging) the PTP sheet, and the processing unit can be one unit of the PTP sheet. If at least one of the routines R1 and R2 is judged to be foreign, the PTP sheet is judged to be defective and can be ejected.
  • FIG. 1 is a diagram (cross-sectional view) showing an outline of the package of the present invention.
  • FIG. 2 is a diagram showing a configuration of an image processing apparatus (23) used in the inspection method of the present invention.
  • FIG. 3 is a diagram for explaining a specific example in which a foreign substance is detected in the foreign substance inspection method.
  • FIG. 3 (a) is a plan view showing a part of the visual inspection range of the PTP film with foreign matter attached.
  • FIG. 3 (b) is a diagram showing the brightness on the line AA ′ of FIG. 3 (a) stored in the third image memory.
  • Fig. 3 (c) is an image of the binarized image taken along the line A-A 'in Fig. 3 (b), which was binarized by the first binarizing means.
  • Fig. 3 (d) is a binarized image of the two-dimensional image of Fig. 3 (a) binarized by the first binarization means.
  • Fig. 3 (e) shows the binarized image data at the line A-A in Fig. 3 (b) binarized by the second binarization means.
  • FIG. 3 (f) shows the binary image data of the two-dimensional image of FIG. 3 (a) binarized by the second binarizing means.
  • FIG. 4 is a flowchart showing a routine of “inspection determination accompanying the first binarization process” executed by the image processing apparatus.
  • FIG. 5 is a flowchart illustrating a routine of “inspection determination accompanying the second binarization process” executed by the image processing apparatus.
  • FIG. 6 is a schematic diagram showing the photometer used in Test Example 1 and its measurement mechanism. BEST MODE FOR CARRYING OUT THE INVENTION
  • An ink containing the components shown in Table 1 (indicating the pigment name and the amount blended in the ink) was prepared.
  • a mixture of nitrocellulose and polyvinyl butyral in a weight ratio of 1: 1 was used as a binder, and was blended so as to be 16% by weight based on the total weight of the ink.
  • the remainder was mixed with a solvent.
  • the solvent used was a mixture of toluene and methyl ethyl ketone at a volume ratio of 1: 1. After compounding the solvent, the mixture was stirred and mixed with a mixer to prepare an ink.
  • the ink viscosity after stirring was about 20 seconds for ZC # 3 (temperature 20 ° C).
  • the letters “ABC” (12-point gothic) were dried by gravure printing on one side of aluminum foil (JIS 8021 hard foil, 20 m thick) to a weight of 0.8 gZm 2 after drying.
  • the printed paper was dried with hot air at 180 ° C for about 20 seconds.
  • a coating agent composed of a vinyl chloride-vinyl acetate copolymer was coated on the printed surface side so as to have a weight of 4. Og / m 2 as a thermal adhesive layer, thereby forming a cover material.
  • Example 7 in place of the aluminum foil using polyethylene te Refutare one Tofuirumu thickness 16, in Example 8, using 40 g / m 2 pure white paper instead of aluminum foil, other steps and conditions Were the same as in Examples 1 to 6.
  • Example mm Compounding amount (wt%) Printed matter detection Reproduction Appearance color Infrared reflection 2
  • Phthalocyanine phenyl-4.0 No black, no brown, green white
  • the infrared reflectance is the average value of the reflectance (%) when irradiating near infrared rays with wavelengths of 800 825 5 850 875 and 90 Onm. From the results in Table 1, it can be seen that the package of the present invention particularly using two or more types of coloring materials as the printing layer can exert excellent effects in both the detection accuracy and visibility of foreign substances.
  • the infrared reflection characteristics of the printed layers of the packages produced in the examples and comparative examples were examined.
  • a package having a size of 5 O mm in length and 35 mm in width was prepared in the same manner as in each Example and Comparative Example. However, the printing layer was solid printing on the entire surface, and tablets were not filled to avoid the effects of tablets.
  • the reflectance (%) of each sample when irradiated with near-infrared rays at wavelengths of 800 nm, 825 nm, 8500 nm, 875 nm and 900 nm was measured, and the average was measured. The value was determined. The results are shown in Table 1.
  • an ultraviolet-visible-near-infrared spectrophotometer product name “JASCOV570”, manufactured by JASCO Corporation
  • Figure 6 shows the outline of the measurement method using the photometer.
  • the specifications of the above photometer were: holder type: integrating sphere, measuring size: length 8 mm x width 9 mm, inner diameter of integrating sphere: 60 mm, coating agent for inner wall of integrating sphere: barium sulfate.
  • the foreign matter inspection method using infrared light can be effectively applied. Foreign matter can be detected.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
  • Packages (AREA)
  • Wrappers (AREA)

Abstract

Cette invention se rapporte à un emballage qui peut être inspecté en toute sécurité en vue de déterminer la présence de matière étrangère même lorsqu'il comporte des couches d'impression, ainsi qu'à un procédé d'inspection de cet emballage en vue de détecter la présence de matière étrangère. A cet effet, le contenu de l'emballage est introduit dans un récipient ayant une partie d'ouverture fermée par un matériau de revêtement. L'emballage se caractérise en ce que : (a) le récipient peut être produit par formation d'un film de résine transparent ou semi-transparent, (b) le matériau de revêtement comprend au moins un matériau à base d'aluminium, un film de résine et du papier, (c) des couches d'impression sont formées sur une partie ou sur la totalité de la partie d'ouverture fermant la face latérale du matériau de revêtement et (d) les couches d'impression comprennent au moins deux colorants formés de pigment et de teinture.
PCT/JP2003/015700 2002-12-10 2003-12-09 Procede d'inspection de matiere etrangere WO2004052747A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003289255A AU2003289255A1 (en) 2002-12-10 2003-12-09 Packaging body and foreign matter inspection method

Applications Claiming Priority (4)

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JP2002-358359 2002-12-10
JP2002358359 2002-12-10
JP2003-181662 2003-06-25
JP2003181662A JP4439206B2 (ja) 2002-12-10 2003-06-25 包装体及び異物検査方法

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WO2004052747A8 WO2004052747A8 (fr) 2005-03-24

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AU (1) AU2003289255A1 (fr)
TW (1) TW200412927A (fr)
WO (1) WO2004052747A1 (fr)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
JP4788870B2 (ja) * 2005-01-26 2011-10-05 シーケーディ株式会社 不良検査装置及びｐｔｐ包装機
JP4258673B2 (ja) * 2005-04-12 2009-04-30 東洋アルミニウム株式会社 積層体及びインキ皮膜
CA2736906C (fr) * 2008-09-12 2018-01-30 Boehringer Ingelheim International Gmbh Unite d'emballage
JP2014090831A (ja) * 2012-11-02 2014-05-19 Sumitomo Bakelite Co Ltd 医薬品包装シート
US20160368642A1 (en) * 2013-07-04 2016-12-22 Noriyuki Inoue Method for inspecting packaging container content
JP6652397B2 (ja) * 2016-02-01 2020-02-19 株式会社明治 包装食品の密封状態判定方法及び密封包装食品の製造方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS624072A (ja) * 1985-06-28 1987-01-10 大日本印刷株式会社 ブリスタ−包装体
JPS635263B2 (fr) * 1985-12-25 1988-02-02 Toray Industries
JPH0592102U (ja) * 1992-05-13 1993-12-14 鐘紡株式会社 ブリスタ包装装置
JPH06255671A (ja) * 1993-02-25 1994-09-13 Toppan Printing Co Ltd 包装材料
JPH0858840A (ja) * 1994-08-23 1996-03-05 Alusuisse Lonza Services Ag ブリスタパック
JPH09169357A (ja) * 1995-09-29 1997-06-30 Johnson & Johnson Vision Prod Inc 透き通るラミネートプラスチック材料構造およびその構造を使用した包装容器
JPH1059416A (ja) * 1996-08-19 1998-03-03 Fuji Seal Co Ltd ブリスター包装体
JP2000146862A (ja) * 1998-11-09 2000-05-26 Ckd Corp Ｐｔｐシートおよびｐｔｐシートの外観検査装置
JP7106622B2 (ja) * 2020-12-16 2022-07-26 東芝エレベータ株式会社 エスカレータ

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS624072A (ja) * 1985-06-28 1987-01-10 大日本印刷株式会社 ブリスタ−包装体
JPS635263B2 (fr) * 1985-12-25 1988-02-02 Toray Industries
JPH0592102U (ja) * 1992-05-13 1993-12-14 鐘紡株式会社 ブリスタ包装装置
JPH06255671A (ja) * 1993-02-25 1994-09-13 Toppan Printing Co Ltd 包装材料
JPH0858840A (ja) * 1994-08-23 1996-03-05 Alusuisse Lonza Services Ag ブリスタパック
JPH09169357A (ja) * 1995-09-29 1997-06-30 Johnson & Johnson Vision Prod Inc 透き通るラミネートプラスチック材料構造およびその構造を使用した包装容器
JPH1059416A (ja) * 1996-08-19 1998-03-03 Fuji Seal Co Ltd ブリスター包装体
JP2000146862A (ja) * 1998-11-09 2000-05-26 Ckd Corp Ｐｔｐシートおよびｐｔｐシートの外観検査装置
JP7106622B2 (ja) * 2020-12-16 2022-07-26 東芝エレベータ株式会社 エスカレータ

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WO2004052747A8 (fr) 2005-03-24
JP4439206B2 (ja) 2010-03-24
AU2003289255A8 (en) 2004-06-30
JP2004239889A (ja) 2004-08-26
TW200412927A (en) 2004-08-01
AU2003289255A1 (en) 2004-06-30

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