WO2004052747A1

WO2004052747A1 - Packaging body and foreign matter inspection method

Info

Publication number: WO2004052747A1
Application number: PCT/JP2003/015700
Authority: WO
Inventors: Yukihiro Taguchi
Original assignee: Ckd Corporation; Toyo Aluminium Kabushiki Kaisha
Priority date: 2002-12-10
Filing date: 2003-12-09
Publication date: 2004-06-24
Also published as: AU2003289255A8; WO2004052747A8; JP4439206B2; JP2004239889A; TW200412927A; AU2003289255A1

Abstract

A packaging body allowing to be surely inspected for foreign matter even when having print layers and a method of inspecting the packaging body for foreign matter, the packaging body wherein contents are filled in a container having an opening part which is closed by a cover material. The packaging body is characterized in that (a) the container can be provided by forming a transparent or semi-transparent resin film, (b) the cover material comprises at least one of an aluminum-based material, resin film, and paper, (c) the print layers are formed on a part or all of the opening part closing side face of the cover material, and (d) the print layers comprise two or more of colorants formed of pigment and dye.

Description

Package and foreign matter inspection method

The present invention relates to a novel package and a foreign matter inspection method. Background art

Light

A press-through pack (PTP) package is leaking as a package for containing drugs (eg, tablets, capsules). PTP packaging is transparent or half-printed

It consists of a container obtained by molding a transparent resin film, and a lid material containing printed aluminum foil. In this case, inspection of foreign matter after packaging is indispensable, depending on the type of contents contained in the PTP package. However, since this package uses aluminum foil, a metal detector cannot be applied. In addition, it is difficult to discriminate a printed layer from a foreign substance by using a photographic method or visual observation. Inspection methods using X-rays are conceivable, but it is difficult to detect organic substances with X-rays.

In recent years, various foreign substance inspection methods have been developed for these methods. For example, Japanese Patent Application Laid-Open No. H11-39484 describes that a video signal obtained by using a PTP sheet by a CCD camera or the like is processed in a specific manner, so that a mesh pattern is formed on the entire inspection object. Despite this, a defect detection method has been proposed that can easily detect foreign matter without depending on lighting technology.

However, according to the above method, when the PTP sheet has a printed portion, the printed portion cannot be distinguished from the foreign matter. In this case, it is conceivable to specify the position of the printing part by pattern matching and mask the printing part in advance.However, the masking process is time-consuming, and if foreign matter is present in the printing part, the foreign matter is masked by the masking. Is hidden and cannot be detected.

Disclosure of the invention

Therefore, the main object of the present invention is to more reliably inspect foreign substances even if they have a printed layer. And a method for inspecting foreign matter therefor.

The present inventor has conducted intensive studies in view of the above-mentioned problems of the prior art, and as a result, has found that a package formed with a specific printing layer can achieve the above object, and has completed the present invention. .

That is, the present invention relates to the following package and foreign matter inspection method.

1. A package in which contents are loaded in a container having an opening, and the opening is closed by a lid material.

(a) the container is obtained by molding a transparent or translucent resin film; (b) the lid material includes at least one of an aluminum-based material, a resin film, and paper; ) A printing layer is formed on part or all of the surface of the lid member on the side that closes the opening, and (d) the printing layer contains at least two types of coloring materials including pigments and dyes.

A package characterized by the above.

2. The package according to the above item 1, wherein the printing layer is a layer that does not absorb infrared rays.

3. The package according to the above item 1, wherein the printing layer reflects near infrared rays by 50% or more.

4. The package according to the above item 1, wherein the printing layer reflects 50% or more of near infrared rays having a wavelength of 800 to 900 nm.

5. The package according to item 1 or 2, wherein the printing layer has a black or brown color.

6. The package according to any one of the above items 1 to 3, wherein the printing layer contains a red pigment, a yellow pigment, and a blue pigment.

7. Two kinds of coloring materials: disazoiello, phthalocyanine blue, dioxazine, villazolo orange, naphthol AS, oxinaphthoic acid, barium salt, talc, calcium carbonate, soluble azo, perylene black and aniline black Item 5. The package according to any one of Items 1 to 4 above.

8. The printed layer contains the dye pump rack and titanium or titanium oxide as a coloring material, the dye black content is 10% by weight or less in the print layer, and the titanium oxide content is printed. Item 6. The package according to any one of Items 1 to 5, wherein the amount of the package is 60% by weight or less in the layer. 9. The printing layer contains ferric oxide and Z or phthalocyanine green as a colorant, and the total content of ferric oxide and phthalocyanine green in the printing layer is 6%. Item 6. The package according to any one of Items 1 to 5, which is 0% by weight or less.

10. The package according to any one of the above items 1 to 9, wherein the content is a drug.

11. The package according to any one of the above items 1 to 10, which is used for foreign substance inspection by infrared light.

12. The package according to any one of the above items 1 to 11, wherein (1) at least (1) the contents, (2) the container, and (3) a red color on a surface of a lid material that closes an opening of the container. Irradiating light including external light, (2) imaging an area irradiated with light including infrared light, and (3) capturing an image obtained by the imaging. A package for use in a foreign substance inspection method having a step of determining the presence or absence of a foreign substance in the package. 13. The method for inspecting foreign matter of a package according to any one of the above items 1 to 11, wherein (1) at least (1) the contents, (2) the container, and (3) a lid material for closing the opening of the container. Irradiating the surface including the infrared light to the surface of the object; (2) imaging the region irradiated with the light including the infrared light; and (3) irradiating the surface within the region from the image data obtained by the imaging. A foreign matter inspection method having a step of determining the presence or absence of a foreign matter in the above.

1. Package of the present invention

The package of the present invention is a package in which contents are loaded into a container having an opening, and the opening is closed by a lid material,

(a) the container is obtained by molding a transparent or translucent resin film; (b) the lid material includes at least one of an aluminum-based material, a resin film, and paper; ) A printed layer is formed on part or all of the surface of the lid member on the side that closes the opening, and (d) the printed layer contains at least two types of coloring materials including pigments and dyes. It is characterized.

The container used in the package of the present invention may be any one obtained by molding a transparent or translucent resin film, and if the material, shape, molding method, etc. are appropriately selected according to the type of the contents, etc. good. For example, when a package that separately contains a plurality of contents is required, a resin film having a plurality of pockets can be used. As the material, for example, vinyl chloride, polypropylene and the like are preferable. In addition, resin The thickness of the lum is not limited, but is preferably about 0.05 to 2 mm. This container can be formed by, for example, a method using a press machine (extension forming, deep drawing forming, etc.) or a method not using a press machine (vacuum forming, pressure forming, etc.). These formings may be either cold forming or hot forming, or may use both together.

The lid material may be any material that includes at least one of an aluminum-based material, a resin film, and paper. For example, an aluminum-based material alone or a laminate of a paper layer, a resin film layer, and the like on an aluminum-based material may be used. Further, it may be formed of a resin film alone or paper alone, or may be a laminate obtained by combining these with other materials. If necessary, an anchor coat layer, a printing layer, a coloring layer, a primer layer, an overcoat layer and the like may be appropriately formed.

The aluminum-based material may be either aluminum or an aluminum-based alloy. Specifically, pure aluminum (JIS (AA) 1000 system, for example, 1N30, 1N700, etc.), A1 Mn system (JIS (AA) 300 system, for example, 300, 304, etc.), A1-Mg system (JIS (AA) 50,000 system), A1-Fe system (JIS (AA) 8000 system, for example, 8 0 2 1, 8 0 7 9 etc.). Components such as Fe, Si, Cu, Ni, Cr, Ti, Zr, Zn, Mn, Mg, and Ga contained in aluminum materials are specified in JIS, etc. It does not matter if the content is within the known range.

The aluminum-based material is desirably used in the form of a foil (sheet). In this case, the thickness is preferably 7 to 50 zm, particularly preferably 10 to 40 m. By setting the value within the above range, more excellent water resistance (moisture resistance), strength, and handling property of the package can be obtained. When an aluminum foil is used as the aluminum-based material, any of a hard material, a semi-hard material, and a soft material may be used, and may be appropriately selected according to the shape of the container, the type of the contents, and the like. In addition, the aluminum foil can be subjected to molding, degreasing, washing, anchor coating, overcoating, surface treatment, and the like, if necessary, by a known method. By using aluminum foil, strength as a packaging material, Barrier properties, preservability, etc. can be exhibited effectively.

When paper is used, for example, pure white roll paper, kraft paper, high-quality paper, imitation paper, western paper, Japanese paper, various types of coated paper, and the like can be used. These can be used alone or in combination of two or more. The thickness of the paper layer is preferably about 10 to L 0 m. By applying a paper layer, curling of the lid material can be prevented, appropriate rigidity can be given to the lid material, and trajectory during manufacturing of the package can be reduced. In addition, there is an advantage that the dead hold property (the shape retention property of the container after opening) can be maintained at the time of opening.

When a resin is used, for example, polyamide (nylon), polyethylene (especially high-density polyethylene), polypropylene (especially stretched polypropylene), vinyl chloride, ethylene-bier alcohol copolymer, polyethylene naphtholate, polyethylene terephthalate, etc. can be used. . These can be used alone or in combination of two or more. Among these, at least one of polyamide and polyester is preferable. These are desirably used as resin films. In this case, the thickness of the resin film layer is preferably about 9 to 50 m. By forming the resin film layer, it is possible to further enhance strength, puncture resistance, water resistance, tear resistance, and the like.

The method for laminating or bonding each layer is not particularly limited, and a known method can be applied. For example, a dry lamination method using a two-component curable urethane-based adhesive such as a polyester urethane-based or polyester-based adhesive, a co-extrusion method, an extrusion coating method, and a thermal lamination method using an anchor coating agent can be used.

In the package of the present invention, a part of the surface (front surface) of the lid on the side that closes the opening of the container (in other words, the side that is joined to the opening with or without the adhesive layer). Or, a printing layer is formed on all of them. The printing layer may be formed at a portion joined to the container opening with or without the adhesive layer interposed therebetween, or may be formed at a portion other than the portion. Further, in the package of the present invention, a print layer may be provided on the surface (the back surface) opposite to the above surface, if necessary. These printing layers may be a single layer or a multilayer consisting of two or more layers.

The printing layer contains two or more kinds of coloring materials consisting of pigments and dyes. In particular, two or more It is desirable to contain the above pigments. These pigments and dyes include known inorganic pigments (e.g., barium sulfate, zinc white, iron black, yellow iron oxide, ultramarine, navy blue, talc, calcium carbonate, cobalt curry, benkara etc.), organic pigments (e.g., monoazo-based pigments). , Condensed azo-based, andraquinone-based, quinacridone-based, isoindolinone-based, thioindigo-based, pyropropyl-based, perylene-based, disazo-based, phthalocyanine-based, etc.), dyes, etc. It can be used as appropriate according to the material of the material. In the present invention, the printing layer is preferably a layer that does not absorb infrared rays. As a result, it is possible to obtain more excellent foreign substance detection accuracy in the foreign substance inspection using infrared light.

In the present invention, "does not absorb infrared light" means that the printed layer formed on the cover material does not absorb infrared light at all, or that it absorbs infrared light within a range that does not hinder the inspection of foreign substances or absorbs infrared light. The case where light is transmitted is also included.

In particular, it is preferable that the printed layer formed on the cover material reflects near infrared rays by 50% or more. Further, it is more preferable that the printed layer formed on the lid material reflects near infrared rays having a wavelength of 800 to 900 nm by 50% or more (especially 65% or more). By having the infrared reflection characteristic, it is possible to achieve higher foreign object detection accuracy.

Therefore, in the present invention, it is desirable to use a coloring material that does not absorb infrared rays. In particular, it is preferable that the colorant which does not absorb infrared rays accounts for 70% by weight or more, particularly 80% by weight or more of the total colorant. Examples of coloring materials that do not absorb infrared rays (coloring materials that transmit infrared rays) include disazoiello, phthalocyanine blue, dioxazine, virazolo orange, naphthol AS, oxinaphthoic acid, barium salt, soluble azo, perylene black and It is preferable to use two or more pigments of aniline black.

In addition to these pigments, there are pigments that can be used in the printing layer of the present invention. For example, when the printing layer contains ferric oxide and Z or phthalocyanine daline as a coloring material, the total content of ferric oxide and phthalocyanine green is not more than 60% by weight in the printing layer. Is preferable, and the effects of the present invention can be effectively exhibited. For the printing layer, prepare an ink containing the coloring material as described above, and apply this on the lid material. What is necessary is just to form by doing. As the ink, for example, an ink containing the coloring material, binder and solvent can be suitably used.

The above-mentioned coloring materials can be used as described above, and the content thereof is not limited, but it is generally preferably about 1 to 30% by weight, particularly preferably 3 to 15% by weight in the ink.

When adjusting the lightness of the print layer, carbon black, carbon, or titanium oxide can be used as a coloring material, if necessary. In this case, it is preferable to adjust the amount of carbon black used so as to be 10% by weight or less in the print layer. The amount of titanium oxide used is preferably adjusted so as to be 60% by weight or less in the printed layer. By setting the values in these ranges, foreign object inspection with higher accuracy can be performed.

The binder is not particularly limited, and examples thereof include nitrocellulose, polyvinyl butyral, phenolic resin, maleic acid resin, alkyd resin, and acrylic resin. These can be used alone or in combination of two or more. The content of the binder is preferably about 5 to 30% by weight in the ink.

Solvents are not limited and include, for example, toluene, xylene, methyl edel ketone, isopropyl alcohol, thinner, ethyl acetate, methyl acetate, butylacetosolve, butyl acetate, methanol, ethanol, butanol, hexane, acetone. Etc. can be used. These can be used alone or in combination of two or more. The amount of the solvent used may constitute the balance of the ink.

In addition, in the above inks, rosin, diethylene glycol, amine, linseed oil, castor oil, stearic acid, oleic acid, etc., as necessary, as well as dispersants, hardeners, anti-settling agents, softeners, antioxidants, constitution Pigments, UV absorbers, leveling agents, surface conditioners, anti-sagging agents, thickeners, defoamers, lubricants, etc. may be added.

When a printing layer is formed using the above ink, the forming method is not particularly limited, and for example, a known printing method can be applied. For example, letterpress printing, intaglio printing, screen printing, offset printing, gravure printing, and the like can be applied. After forming the printing layer, it can be subjected to a drying step, if necessary. For example, by setting the condition from room temperature (20 ° C) to about 250 ° C for about 10 seconds to 10 hours, Can be dried. When drying continuously, it may be designed so that it can be dried by blowing hot air or move in an oven.

The color of the print layer is not limited, but it is desirable that the print layer exhibit a black or brown color from the viewpoint of visibility and the like. In particular, when the printing layer is made black, it is possible to use a mixed pigment composed of three kinds of pigments: a red pigment (for example, barium salt), a yellow pigment (for example, diazoiellone), and a blue pigment (for example, phthalocyanine blue). preferable.

The thickness of the printing layer is not limited, but is preferably 0.1 to about L 0 / m. The weight of the printing layer (weight after drying) is 0. It is preferable to 1~1 O gZm ² about.

In the package of the present invention, the container opening is closed by the lid material. This method is not particularly limited, and a known method can be applied. For example, there is a method using an adhesive. In the present invention, it is particularly preferable to use a heat sealing method in which a heat bonding layer (heat bonding resin layer) is interposed.

Known materials can be used as the heat-adhesive resin. For example, high-density polyethylene, medium-density polyethylene, low-density polyethylene, linear linear polyethylene, saturated polyester, linear saturated polyester, undrawn polypropylene, chlorinated polypropylene, ethylene-acrylic acid copolymer, ethylene-methacrylic acid Copolymer, ethylene-ethyl acrylate copolymer, ethylene-methyl acrylate copolymer, ionomer, ethylene-ethyl acrylate-maleic anhydride terpolymer, polyolefin, carboxylic acid modified Examples include polyethylene, carboxylic acid-modified polypropylene, carboxylic acid-modified ethylene-viel acetate, vinyl chloride, and polystyrene. Also, commercially available products such as “Bondane” manufactured by Sumitomo Chemical Co., Ltd. and “Mersen M” manufactured by Tosoh Corporation can be used. One or more of these thermoadhesive resins can be used.

The thermal bonding layer may be formed on at least one of the lid and the container, but is particularly preferably formed on the lid. The heat bonding layer is formed by applying a liquid adhesive containing the above resin or laminating a heat bonding film made of the above resin. be able to. Although the thickness of the heat bonding layer is not limited, it is usually preferable to be about 2 to about L00 m.

The conditions for heat sealing can be changed as appropriate depending on the type of thermal adhesive to be used, the type of contents, and the like, but generally it is sufficient to set the temperature at 140 to 260 ° C for about 1 to 3 seconds. After heat sealing, if necessary, a ring seal (also referred to as a “line seal”) is applied so that the cross-sectional shape of the package is concave, or the above-mentioned cross-sectional shape is formed into a continuous uneven shape. A mesh seal can be applied. Also, instead of the heat seal using a hot plate, an ultrasonic seal, an induction heat seal, or the like can be adopted.

The contents to be loaded into the container of the package of the present invention are not particularly limited, and the contents filled and loaded into a known PTP package can be applied as they are. It is desirable that the contents be solid. Examples include pharmaceuticals (pharmaceuticals), foods, electronic components, contact lenses, fragrances, detergents, and the like. In particular, it is suitable for drugs that require foreign substance inspection. Further, the drug may be any of tablets, capsules and the like. The contents may be printed (sealed) as necessary. In this case, the print is desirably a print layer that does not absorb infrared rays. As such a printing layer, the same one as described above can be employed.

The package of the present invention can be applied to foreign matter inspection using infrared light. More specifically, it can be suitably used in the foreign matter inspection method of the present invention described later. By applying the package of the present invention to the above-described inspection method, it is possible to detect foreign substances with high accuracy.

FIG. 1 shows a schematic view of the package of the present invention. Aluminum foil is used as the cover material (1), and a printed layer (3) is formed on the surface (6) of the cover material that is joined to the transparent container (2) via the thermal adhesive layer (5). . The transparent container is loaded with tablets (4) as contents. Then, the lid member and the transparent container are joined by a heat seal via the heat bonding layer (5), and the opening of the transparent container is closed by the lid member. As a result, a package is obtained in which the print layer is formed on part or all of the surface (6) of the lid on the side that closes the opening. 2. Foreign matter inspection method

The foreign matter inspection method of the present invention is a foreign matter inspection method of the package of the present invention,

(1) A step of irradiating at least (1) the content, (2) the container, and (3) the surface of the lid on the side that closes the opening of the container with light including infrared light [First step], (2) Infrared light (2) a step of imaging an area irradiated with light including: (3) a step [3] of judging the presence or absence of a foreign substance in the area from image data obtained by the imaging; .

[First step]

In this step, at least (1) the contents, (2) the container, and (3) the surface of the lid that closes the opening of the container is irradiated with light including infrared light. As light including infrared light, light including infrared light and light in a wavelength region other than infrared light (eg, visible light) can be used.

The irradiation time, irradiation area, intensity, and the like of light including infrared light can be appropriately adjusted according to the type of the contents. A known device can be used as the device for irradiating light.

[Second step]

In this step, an area irradiated with light including infrared light is imaged. In the present invention, it is desirable to take an image (two-dimensional imaging) of reflected light from a region irradiated with light including infrared light by an imaging means having sensitivity to infrared light.

Examples of the imaging means include a camera having sensitivity only to infrared light, and a camera having sensitivity to infrared light provided with a filter that transmits only infrared light. These may be known or commercially available ones. For example, a commercially available CCD camera or the like can be used.

[Third step]

In this step, the presence or absence of a foreign substance in the area is determined from the image data obtained by the imaging. The determination method is not particularly limited as long as it is a method that can detect a foreign substance in distinction from the print layer. For example, the following approach can be taken. In the image data obtained by the imaging means having sensitivity to infrared light, the brightness of the contents is higher than the brightness of the container (resin film) regardless of the color of the contents. In addition, the brightness of foreign matter on the contents, cracks and chipping of the contents is lower than the brightness of the contents, and the brightness of the foreign substances on the resin film is lower than the brightness of the resin film. When the printing layer is a layer that does not absorb infrared rays, the difference in brightness between the printing layer and the resin film is extremely small. The image having the difference in brightness may be processed by means as shown in FIG.

FIG. 2 shows the configuration of the image processing device (23). This device (means) includes an AZD converter (27), shading correction means (28), first binarization means (29), first image memory (30), second binarization means (31 ), Second image memory (32), judgment memory (34), CPU and input / output interface (35), third image memory (33), visual inspection result and statistical data memory (36), It consists of camera timing control means (37).

The AZD converter (27) converts a two-dimensional image captured by a CCD camera (22) as an imaging means from an analog signal to a digital signal. The converted image data is subjected to shading correction by the shading correction means (28) according to the data of the shading correction table (38), and then stored in the third image memory (33).

The shading correction is performed, if it is difficult to uniformly irradiate the entire imaging area of the resin film with light including infrared light, if necessary. Can be done to correct

The data relating to the corrected brightness is binarized by the first binarizing means (29) with the first threshold value δ1, and is sequentially stored in the first image memory (30). Thereby, first binary image data of the resin film is formed. The first threshold value δ 判定する is used to determine a foreign substance in the area where the content exists (content area). As the first threshold value δΐ, for example, a value that is lighter than the resin film and the foreign material serving as the background of the content and a value that is darker than the content is selected. In the present invention, the first threshold value 01 is preferably set to a value slightly lower than the brightness of the contents.

Further, the corrected data relating to the brightness is binarized by the second binarization means (31) with the second threshold value 02, and then stored in the second image memory (32). Thereby, the second binary image data of the resin film is formed. The second threshold value <52 is mainly for determining foreign substances present in the resin film. As the second threshold value δ2, a value darker than the resin film and the printing layer is selected. In the present invention, the second threshold value Δ2 is preferably set to a value slightly lower than the brightness of the resin film.

The CPU and the input / output interface (35) execute programs such as various image processing programs while using the contents of the memory for judgment (34) and send control signals to the PTP packaging machine (11). It is for sending out or receiving various signals such as operation signals from the PTP packaging machine (11). This makes it possible to control, for example, a defective sheet discharging mechanism of the PTP packaging machine (11). Further, the CPU and the input / output interface (35) have a function of transmitting display data to the monitor (24). With this function, it is possible to display on a monitor (24) a binary or shaded image, a visual inspection result, and the like.

The visual inspection result and statistical data memory (36) stores data such as coordinates relating to the image data, visual inspection result data, statistical data obtained by statistically processing the visual inspection result data, and the like. These data can be displayed on the monitor (24) based on the control of the CPU and the input / output interface (35). Also, based on these data, the CPU and input / output interface (35) can send control signals to the PTP packaging machine (11). The keyboard (25) is used to input settings such as reference values for pass / fail judgment stored in the judgment memory (34).

The camera timing control means (37) controls the timing at which image data captured by the CCD camera (22) is taken into the AZD converter (27). This timing is controlled based on a signal from an encoder (not shown) provided in the PTP packaging machine (11), and an image is taken by the CCD camera (22) every time a predetermined amount of resin film is sent. Be done.

Next, a description will be given of an example of a case in which a defect in appearance due to foreign matter is detected, together with the procedure of the appearance inspection, with reference to FIGS.

Fig. 3 (a) shows the appearance inspection range of a resin film (PTP film) as a specific example. Part of the box (this inspection area is indicated as “P”). The container (pocket) formed by molding the PTP film contains as the contents. The letter “C” is stamped on this lj, and it is assumed that foreign matter Dx is attached. It is assumed that the character “123” is printed on the cover film serving as the cover material, and that the foreign matter Dy is attached.

The PTP film is imaged by a CCD camera, corrected for shading, and stored in a third image memory (33). For example, the brightness of the stored image on the line AA ′ in FIG. 3 (a) is high in the content area (麵 area) as shown in FIG. 3 (b), and the area of the cover film and the foreign substance area are high. Becomes lower.

Next, the routine R1 is executed according to the flowchart shown in FIG. In the routine R1, “the inspection determination accompanying the first binarization process” is executed by the image processing device (23) (mainly the CPU). First, in step S1, the image processing device (23) forms first binary image data by the first binary image forming means (29), and stores this data in the first image memory. (30) (first binarization process). That is, assuming that 1 (bright) is greater than or equal to the first threshold value δ 、 and 0 (dark) is less than the first threshold value, in this inspection range Α, Α—Α and the data on the line are as shown in FIGS. The dimensional image is converted to binary image data as shown in Fig. 3 (d).

In step S2, block processing is performed on the first binarized image data stored in the first image memory (30). The lump processing includes processing to identify each connected component for 0 (成分) and 1 (bright) in the binarized image data, and label processing for labeling each connected component. Here, the occupied area of each specified connected component is represented by the number of dots corresponding to the pixel of the CCD camera (22).

In step S3, the image processing device (23) selects, from among the 1 (bright) connected components obtained from the first binarized image, the connected component corresponding to the tablet having the above-mentioned seal. To identify. A connected component corresponding to a tablet can be easily determined by a determination method of a connected component including predetermined coordinates, a connected component having a predetermined shape, a connected component having a predetermined area, or the like. That is, the tablet area) can be specified. Therefore, in this inspection area P, the tablet area J containing the foreign matter Dx (Fig. 3 (See (d)).

In step S4, the image processing device (23) calculates the area Sx of the foreign substance in the tablet area. That is, among the 0 (dark) connected components obtained from the first binary image, the one included in or connected to the coordinates of the tablet region specified in step S3 is extracted, and its area Sx Ask for. Therefore, in the inspection range P, the area of the foreign matter Dx is calculated.

In step S5, the area S X of the foreign matter is compared with a predetermined criterion value P. If the area Sx of the foreign matter is smaller than the determination reference value Px, the process proceeds to step S6, and a non-foreign matter determination (normality determination) is performed. Therefore, in the inspection range P, it is determined whether or not the foreign matter Dx is a foreign matter by comparing the area of the foreign matter Dx with the determination reference value Px. As described above, in the routine R1, the presence / absence of a foreign substance in the tablet area is determined, regardless of the presence / absence of the stamped part, after specifying the eyelet area. FIG. 5 is a flowchart showing the routine R2. In the routine R2, "the inspection determination accompanying the second binarization process" is executed by the image processing device (23). First, in step S11, the image processing device (23) creates second binary image data by the second binarizing means (31), and stores this data in the second image memory. (32). In other words, assuming that the second threshold value <52 is 1 (bright) and the second threshold value <52 is 0 (dark), the data on the line A-A ' The two-dimensional image is converted to binary image data as shown in Fig. 3 (f).

In step S12, the same block processing as in step S2 is performed on the second binarized image data stored in the second image memory (32).

In step S13, the image processing device (23) calculates the area Sy of the foreign matter Dy. That is, a connected component of 0 (dark) obtained from the second binary image data is extracted and its area Sy is obtained. Therefore, in the inspection range P, the area Sy of the foreign matter Dy is calculated.

In step S14, the area Sy of the foreign object is compared with a predetermined determination reference value Py. If the area Sy of the foreign matter is smaller than the determination reference value Py, the process proceeds to step S15, and a non-foreign matter determination (normal determination) is performed. On the other hand, the area Sy If the value is equal to or greater than the fixed reference value Py, the process proceeds to step 16 and a foreign object determination (abnormality determination) is performed in step 16. Therefore, in the inspection range P, the area of the foreign matter Dy is compared with the determination reference value Py to determine whether the foreign matter Dy is a foreign matter. As described above, in the routine R2, it is mainly determined whether or not there is a foreign substance on the cover film regardless of the presence or absence of the print layer.

The processing of the above routines R1 and R2 is executed in the process of manufacturing (pharmaceutical packaging) the PTP sheet, and the processing unit can be one unit of the PTP sheet. If at least one of the routines R1 and R2 is judged to be foreign, the PTP sheet is judged to be defective and can be ejected.

According to the package and the foreign matter inspection method of the present invention, since two or more kinds of coloring materials are used for the print layer, more excellent visibility and design can be exhibited.

In particular, when a printing layer that does not absorb infrared light is applied to the package of the present invention, the foreign matter inspection method using infrared light can be effectively applied. Foreign matter can be detected. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a diagram (cross-sectional view) showing an outline of the package of the present invention.

FIG. 2 is a diagram showing a configuration of an image processing apparatus (23) used in the inspection method of the present invention.

FIG. 3 is a diagram for explaining a specific example in which a foreign substance is detected in the foreign substance inspection method.

① Fig. 3 (a) is a plan view showing a part of the visual inspection range of the PTP film with foreign matter attached.

(2) FIG. 3 (b) is a diagram showing the brightness on the line AA ′ of FIG. 3 (a) stored in the third image memory.

③ Fig. 3 (c) is an image of the binarized image taken along the line A-A 'in Fig. 3 (b), which was binarized by the first binarizing means.

④ Fig. 3 (d) is a binarized image of the two-dimensional image of Fig. 3 (a) binarized by the first binarization means. ⑤ Fig. 3 (e) shows the binarized image data at the line A-A in Fig. 3 (b) binarized by the second binarization means.

⑥ FIG. 3 (f) shows the binary image data of the two-dimensional image of FIG. 3 (a) binarized by the second binarizing means.

FIG. 4 is a flowchart showing a routine of “inspection determination accompanying the first binarization process” executed by the image processing apparatus.

FIG. 5 is a flowchart illustrating a routine of “inspection determination accompanying the second binarization process” executed by the image processing apparatus.

FIG. 6 is a schematic diagram showing the photometer used in Test Example 1 and its measurement mechanism. BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, examples and comparative examples are shown, and the features of the present invention will be described in more detail. However, the scope of the present invention is not limited to these examples.

Examples 1 to 8 and Comparative Examples 1 to 7

An ink containing the components shown in Table 1 (indicating the pigment name and the amount blended in the ink) was prepared. In addition to these components, a mixture of nitrocellulose and polyvinyl butyral in a weight ratio of 1: 1 was used as a binder, and was blended so as to be 16% by weight based on the total weight of the ink. The remainder was mixed with a solvent. The solvent used was a mixture of toluene and methyl ethyl ketone at a volume ratio of 1: 1. After compounding the solvent, the mixture was stirred and mixed with a mixer to prepare an ink. The ink viscosity after stirring was about 20 seconds for ZC # 3 (temperature 20 ° C).

Next, using each ink, the letters “ABC” (12-point gothic) were dried by gravure printing on one side of aluminum foil (JIS 8021 hard foil, 20 m thick) to a weight of 0.8 gZm ² after drying. After printing, the printed paper was dried with hot air at 180 ° C for about 20 seconds. After drying, a coating agent composed of a vinyl chloride-vinyl acetate copolymer was coated on the printed surface side so as to have a weight of 4. Og / m ² as a thermal adhesive layer, thereby forming a cover material. After filling tablets (diameter 7mm x height 3.5mm) into a transparent container made of a vinyl chloride film (thickness 0.3mm), mesh sealing is performed at 180 ° C for 3 seconds using the above lid material. PTP packaging as shown in 1 The body was made. The interface between the thermal adhesive layer of each package and the transparent container was preliminarily mixed with 5 pieces each of 1) hair (5 mm long), 2) dead mosquitoes, and 3) pieces of paper (2 mm square) as foreign matter. .

In Example 7, in place of the aluminum foil using polyethylene te Refutare one Tofuirumu thickness 16, in Example 8, using 40 g / m ² pure white paper instead of aluminum foil, other steps and conditions Were the same as in Examples 1 to 6.

Foreign matter inspection was performed by irradiating infrared light from the transparent container side of the prepared PTP package containing foreign matter. The results are shown in Table 1. The inspection device used was a tablet image inspection device sold by KK (product name “Flash Patri FP600-E” manufactured by CKD Corporation). The evaluation criteria are as follows.

Detection>

Detects all foreign objects

Unable to detect all foreign objects…

Looks brilliant from any direction ···

Difficult to read when light is reflected… X

Example mm Compounding amount (wt%) Printed matter detection Reproduction Appearance color Infrared reflection 2

1 Naphtole AS 3.0

Phthalocyaninyl-2.2

'N' Sari 'Yellow-1.4

Total 6.6 Aluminum foil 〇 Black 6 9.

2 C * ium salt 1.4

Phthalocyanine Bull-2.0

'Sari' Ye D-7.7

Total 1 1. 1 Aluminum 滔〇 Black 6 8

3 Oxidation titanium 7.0

Λ '' 脑 1.0

lid. Xianmple-1.2

'Sari' Ye Π- 2.2

Total 11.4 Aluminum foil o〇 o X X X X o o グレー Gray-6 2

4 Lid ニンニン-4.0

'Sari' Ye Π- 7.0

Total 11.0 Aluminum foil 〇〇 Green 7 0

5 Naftle AS 4.3

Phthalocyanine Bull-0.5

Cover Π ニンニン 'リ-5. 5.6 ¾

Total 1 0.4 Aluminum foil 〇茶 Brown 6 2

6 Phthalocyanine phenyl-4.0 No black, no brown, green white

Shi 'Suasso' Yellow-7.0

Force-Homplac 2.0

Total 13.0 Aluminum foil 〇〇 5 5

7 Naftle AS 3.0

Phthalocyanine Bull-2.2

Shi'sari 'Ye α-1.4

Total 6.6 16 mPET film 〇〇 8 9

8 Naftle AS 3.0

Phthalocyanin '2.2

'N' Sari 'Ye Π-1.4

Total 6. 6 40 g / m ² pure white paper O O Black 8 6 Comparative Example

1 Titanium oxide 3 4 Aluminum foil 4 9

2 Power-housing rack 1 1 Aluminum foil 7

3 Ferric oxide 2 5 Aluminum foil 4 6

4 Lid D-Shanink 'Lean 1 2 Aluminum foil 4 8

5 No seal layer 0 Aluminum foil 8 3

6 No printing layer 0 16 mPET film

7 No printing layer 0 40 g / m ² Pure white paper 9 8

* The infrared reflectance is the average value of the reflectance (%) when irradiating near infrared rays with wavelengths of 800 825 5 850 875 and 90 Onm. From the results in Table 1, it can be seen that the package of the present invention particularly using two or more types of coloring materials as the printing layer can exert excellent effects in both the detection accuracy and visibility of foreign substances.

Test example 1

The infrared reflection characteristics of the printed layers of the packages produced in the examples and comparative examples were examined. First, as a test sample, a package having a size of 5 O mm in length and 35 mm in width was prepared in the same manner as in each Example and Comparative Example. However, the printing layer was solid printing on the entire surface, and tablets were not filled to avoid the effects of tablets. Next, the reflectance (%) of each sample when irradiated with near-infrared rays at wavelengths of 800 nm, 825 nm, 8500 nm, 875 nm and 900 nm was measured, and the average was measured. The value was determined. The results are shown in Table 1.

As the above-mentioned measuring device, an ultraviolet-visible-near-infrared spectrophotometer (product name “JASCOV570”, manufactured by JASCO Corporation) was used. Figure 6 shows the outline of the measurement method using the photometer. The specifications of the above photometer were: holder type: integrating sphere, measuring size: length 8 mm x width 9 mm, inner diameter of integrating sphere: 60 mm, coating agent for inner wall of integrating sphere: barium sulfate.

The results in Table 1 show that the printed layer of the package of the present invention has an infrared reflectance of 50% or more. Industrial potential

According to the package and the foreign matter inspection method of the present invention, since ^two or more kinds of coloring materials are used for the print layer, more excellent visibility and design can be exhibited.

In particular, when a printing layer that does not absorb infrared light is applied to the package of the present invention, the foreign matter inspection method using infrared light can be effectively applied. Foreign matter can be detected.

Claims

The scope of the claims

I. A package in which contents are loaded into a container having an opening, and the opening is closed by a lid material,

A package characterized by the above.

2. The package according to claim 1, wherein the printing layer is a layer that does not absorb infrared rays.

3. The package according to claim 1, wherein the printing layer reflects near infrared rays by 50% or more.

4. The package according to claim 1, wherein the printing layer reflects near infrared rays having a wavelength of 800 to 900 nm by 50% or more.

5. The package according to claim 1, wherein the printed layer has a black or brown color. 6. The package according to claim 1, wherein the printing layer contains a red pigment, a yellow pigment, and a blue pigment.

7. The coloring material is two or more of disazoyello, phthalocyanine blue, dioxazine, virazolo orange, naphthol AS, oxinaphthoic acid, norium salt, talc, calcium carbonate, soluble azo, perylene black and aniline black. 2. The package according to claim 1, which is above.

8. The printing layer contains carbon black and Z or titanium oxide as a coloring material, the content of carbon black is 10% by weight or less in the printing layer, and the content of titanium oxide is 6% in the printing layer. 2. The package according to claim 1, which is 0% by weight or less.

9. The printing layer contains ferric oxide and Z or phthalocyanine green as a colorant, and the total content of ferric oxide and phthalocyanine green in the printing layer

2. The package according to claim 1, which is not more than 60% by weight.

10. The package according to claim 1, wherein the content is a drug.

II. The package according to claim 1, which is used for foreign substance inspection by infrared light. 1 2. The package according to claim 1, wherein (1) at least the contents (2) a step of irradiating the surface of the container and (3) the lid material on the side that closes the opening of the container with light containing infrared light, and (2) a step of imaging an area irradiated with the light containing infrared light. And (3) a package for use in a foreign substance inspection method including a step of determining the presence or absence of a foreign substance in the area from image data obtained by imaging.

13. The method for inspecting foreign matter of a package according to claim 1, wherein (1) at least (1) the contents, (2) the container, and (3) the surface of the lid material that closes an opening of the container. A step of irradiating light including infrared light, (2) a step of imaging an area irradiated with light including infrared light, and (3) a step of irradiating light in the area from image data obtained by imaging. A foreign matter inspection method including a step of determining the presence or absence of foreign matter in a foreign matter.