WO2004043957A1 - Derives d’imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Derives d’imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDFInfo
- Publication number
- WO2004043957A1 WO2004043957A1 PCT/FR2003/003277 FR0303277W WO2004043957A1 WO 2004043957 A1 WO2004043957 A1 WO 2004043957A1 FR 0303277 W FR0303277 W FR 0303277W WO 2004043957 A1 WO2004043957 A1 WO 2004043957A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compounds
- group
- alkyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UAA200505316A UA80579C2 (en) | 2002-11-05 | 2003-04-11 | Imidazopyridine compounds, method of their obtaining and pharmaceutical composition that comprises them |
MXPA05004791A MXPA05004791A (es) | 2002-11-05 | 2003-11-04 | Derivados de imidazopiridina, metodo de preparacion y composiciones farmaceuticas que los contienen. |
DE60307875T DE60307875T2 (de) | 2002-11-05 | 2003-11-04 | Imidazopyrin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusamensetzungen |
EP03767889A EP1558612B1 (fr) | 2002-11-05 | 2003-11-04 | Derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2004550729A JP2006508111A (ja) | 2002-11-05 | 2003-11-04 | イミダゾピリジン誘導体、その調製方法及びそれを含有する医薬組成物 |
BR0315800-4A BR0315800A (pt) | 2002-11-05 | 2003-11-04 | Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm |
CA002504008A CA2504008A1 (fr) | 2002-11-05 | 2003-11-04 | Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU2003292323A AU2003292323A1 (en) | 2002-11-05 | 2003-11-04 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same |
US10/533,699 US7098220B2 (en) | 2002-11-05 | 2003-11-04 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same |
EA200500717A EA008446B1 (ru) | 2002-11-05 | 2003-11-04 | Соединения имидазопиридина, способ их получения и фармацевтические композиции, которые их содержат |
SI200330428T SI1558612T1 (sl) | 2002-11-05 | 2003-11-04 | Derivati imidazopiridina, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
NZ539599A NZ539599A (en) | 2002-11-05 | 2003-11-04 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same |
NO20052710A NO20052710L (no) | 2002-11-05 | 2005-06-06 | Nye imidazopyridinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem |
HK06102330A HK1081964A1 (en) | 2002-11-05 | 2006-02-22 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same |
CY20061101581T CY1105752T1 (el) | 2002-11-05 | 2006-11-02 | Παραγωγα ιμιδαζοπυριδινης μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα πepιεχουν |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0213802A FR2846656B1 (fr) | 2002-11-05 | 2002-11-05 | Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR02/13802 | 2002-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004043957A1 true WO2004043957A1 (fr) | 2004-05-27 |
Family
ID=32104440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/003277 WO2004043957A1 (fr) | 2002-11-05 | 2003-11-04 | Derives d’imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (27)
Country | Link |
---|---|
US (1) | US7098220B2 (fr) |
EP (1) | EP1558612B1 (fr) |
JP (1) | JP2006508111A (fr) |
KR (1) | KR100717488B1 (fr) |
CN (1) | CN100335480C (fr) |
AR (1) | AR041882A1 (fr) |
AT (1) | ATE337317T1 (fr) |
AU (1) | AU2003292323A1 (fr) |
BR (1) | BR0315800A (fr) |
CA (1) | CA2504008A1 (fr) |
CY (1) | CY1105752T1 (fr) |
DE (1) | DE60307875T2 (fr) |
DK (1) | DK1558612T3 (fr) |
EA (1) | EA008446B1 (fr) |
ES (1) | ES2271653T3 (fr) |
FR (1) | FR2846656B1 (fr) |
HK (1) | HK1081964A1 (fr) |
MA (1) | MA27411A1 (fr) |
MX (1) | MXPA05004791A (fr) |
MY (1) | MY135191A (fr) |
NO (1) | NO20052710L (fr) |
NZ (1) | NZ539599A (fr) |
PL (1) | PL375373A1 (fr) |
PT (1) | PT1558612E (fr) |
UA (1) | UA80579C2 (fr) |
WO (1) | WO2004043957A1 (fr) |
ZA (1) | ZA200503234B (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1754483A1 (fr) | 2005-08-18 | 2007-02-21 | Merck Sante | Utilisation des dérivés de thiénopyridone comme activateurs de l'AMPK et compositions pharmaceutiques les contenant |
WO2008006432A1 (fr) | 2006-07-13 | 2008-01-17 | Merck Patent Gmbh | Utilisation de dérivés d'imidazole activateurs d'ampk, procédé de préparation de ces composés, et compositions pharmaceutiques pourvues de ceux-ci |
WO2010103040A1 (fr) | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Activateurs de protéine kinases activées par le 5'-adénosine monophosphate (ampk), destinés au traitement de l'hypertension pulmonaire |
WO2011058193A1 (fr) | 2009-11-16 | 2011-05-19 | Mellitech | Dérivés de [1,5]-diazocine |
EP2906040A4 (fr) * | 2012-08-22 | 2016-07-06 | Merck Sharp & Dohme | Nouveaux dérivés de benzimidazole tétrahydropyrane |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008016730A2 (fr) * | 2006-08-02 | 2008-02-07 | Targeted Molecular Diagnostics, Llc | Compositions et procédés pour réduire la graisse cellulaire |
US8163505B2 (en) | 2007-05-22 | 2012-04-24 | The Penn State Research Foundation | Methods using PBK1 for identifying agents that treat metabolic disorders |
WO2010030360A1 (fr) * | 2008-09-11 | 2010-03-18 | Arena Pharmaceuticals, Inc. | Dérivés 3h-imidazo[4,5-b]pyridin-5-ol utiles dans le traitement de troubles du récepteur gpr81 |
MX2011003239A (es) * | 2008-09-26 | 2011-04-28 | Merck Sharp & Dohme | Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos. |
CA2741125A1 (fr) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Nouveaux derives de benzimidazole cycliques utiles comme agents anti-diabetiques |
WO2010051206A1 (fr) * | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Nouveaux agents antidiabétiques utiles avec des dérivés de benzimidazole cycliques |
US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US9133186B2 (en) | 2010-09-10 | 2015-09-15 | Shionogi & Co., Ltd. | Hetero ring-fused imidazole derivative having AMPK activating effect |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
ES2885424T3 (es) * | 2013-03-15 | 2021-12-13 | Knopp Biosciences Llc | Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7 |
JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
US9481653B2 (en) | 2014-09-12 | 2016-11-01 | Knopp Biosciences Llc | Benzoimidazol-1,2-yl amides as Kv7 channel activators |
WO2023044364A1 (fr) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Inhibiteurs de protoporphyrinogène oxydase |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0638568A1 (fr) * | 1993-07-23 | 1995-02-15 | Adir Et Compagnie | Pipérazines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant |
WO1998025921A1 (fr) * | 1996-12-11 | 1998-06-18 | Rhône-Poulenc Rorer Pharmaceuticals Inc. | PREPARATION DE [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL) METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-YL]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE |
WO2000012089A1 (fr) * | 1998-08-31 | 2000-03-09 | Merck & Co., Inc. | Nouveaux inhibiteurs d'angiogenese |
US20020082425A1 (en) * | 1999-04-02 | 2002-06-27 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives |
-
2002
- 2002-11-05 FR FR0213802A patent/FR2846656B1/fr not_active Expired - Fee Related
-
2003
- 2003-04-11 UA UAA200505316A patent/UA80579C2/uk unknown
- 2003-10-09 MY MYPI20033845A patent/MY135191A/en unknown
- 2003-11-04 AU AU2003292323A patent/AU2003292323A1/en not_active Abandoned
- 2003-11-04 BR BR0315800-4A patent/BR0315800A/pt not_active IP Right Cessation
- 2003-11-04 PT PT03767889T patent/PT1558612E/pt unknown
- 2003-11-04 EP EP03767889A patent/EP1558612B1/fr not_active Expired - Lifetime
- 2003-11-04 EA EA200500717A patent/EA008446B1/ru not_active IP Right Cessation
- 2003-11-04 CN CNB2003801027143A patent/CN100335480C/zh not_active Expired - Fee Related
- 2003-11-04 AT AT03767889T patent/ATE337317T1/de not_active IP Right Cessation
- 2003-11-04 MX MXPA05004791A patent/MXPA05004791A/es active IP Right Grant
- 2003-11-04 US US10/533,699 patent/US7098220B2/en not_active Expired - Fee Related
- 2003-11-04 WO PCT/FR2003/003277 patent/WO2004043957A1/fr active IP Right Grant
- 2003-11-04 DK DK03767889T patent/DK1558612T3/da active
- 2003-11-04 NZ NZ539599A patent/NZ539599A/en unknown
- 2003-11-04 AR ARP030104024A patent/AR041882A1/es not_active Application Discontinuation
- 2003-11-04 JP JP2004550729A patent/JP2006508111A/ja active Pending
- 2003-11-04 ES ES03767889T patent/ES2271653T3/es not_active Expired - Lifetime
- 2003-11-04 DE DE60307875T patent/DE60307875T2/de not_active Expired - Fee Related
- 2003-11-04 CA CA002504008A patent/CA2504008A1/fr not_active Abandoned
- 2003-11-04 KR KR1020057007914A patent/KR100717488B1/ko not_active IP Right Cessation
- 2003-11-04 PL PL03375373A patent/PL375373A1/xx not_active Application Discontinuation
-
2005
- 2005-04-19 MA MA28233A patent/MA27411A1/fr unknown
- 2005-04-21 ZA ZA200503234A patent/ZA200503234B/en unknown
- 2005-06-06 NO NO20052710A patent/NO20052710L/no not_active Application Discontinuation
-
2006
- 2006-02-22 HK HK06102330A patent/HK1081964A1/xx not_active IP Right Cessation
- 2006-11-02 CY CY20061101581T patent/CY1105752T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0638568A1 (fr) * | 1993-07-23 | 1995-02-15 | Adir Et Compagnie | Pipérazines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant |
WO1998025921A1 (fr) * | 1996-12-11 | 1998-06-18 | Rhône-Poulenc Rorer Pharmaceuticals Inc. | PREPARATION DE [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL) METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-YL]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE |
WO2000012089A1 (fr) * | 1998-08-31 | 2000-03-09 | Merck & Co., Inc. | Nouveaux inhibiteurs d'angiogenese |
US20020082425A1 (en) * | 1999-04-02 | 2002-06-27 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives |
Non-Patent Citations (1)
Title |
---|
OGUCHI, MINORU ET AL: "Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones", JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(16), 3052-3066, XP002242679 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1754483A1 (fr) | 2005-08-18 | 2007-02-21 | Merck Sante | Utilisation des dérivés de thiénopyridone comme activateurs de l'AMPK et compositions pharmaceutiques les contenant |
WO2008006432A1 (fr) | 2006-07-13 | 2008-01-17 | Merck Patent Gmbh | Utilisation de dérivés d'imidazole activateurs d'ampk, procédé de préparation de ces composés, et compositions pharmaceutiques pourvues de ceux-ci |
WO2010103040A1 (fr) | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Activateurs de protéine kinases activées par le 5'-adénosine monophosphate (ampk), destinés au traitement de l'hypertension pulmonaire |
WO2011058193A1 (fr) | 2009-11-16 | 2011-05-19 | Mellitech | Dérivés de [1,5]-diazocine |
US8765728B2 (en) | 2009-11-16 | 2014-07-01 | Mellitech | [1,5]-diazocin derivatives |
EP2906040A4 (fr) * | 2012-08-22 | 2016-07-06 | Merck Sharp & Dohme | Nouveaux dérivés de benzimidazole tétrahydropyrane |
US9527839B2 (en) | 2012-08-22 | 2016-12-27 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydropyran derivatives |
Also Published As
Publication number | Publication date |
---|---|
ATE337317T1 (de) | 2006-09-15 |
MXPA05004791A (es) | 2005-07-22 |
US7098220B2 (en) | 2006-08-29 |
BR0315800A (pt) | 2005-09-20 |
CA2504008A1 (fr) | 2004-05-27 |
EP1558612A1 (fr) | 2005-08-03 |
DK1558612T3 (da) | 2006-12-27 |
ZA200503234B (en) | 2006-06-28 |
PL375373A1 (en) | 2005-11-28 |
ES2271653T3 (es) | 2007-04-16 |
DE60307875T2 (de) | 2007-04-12 |
FR2846656A1 (fr) | 2004-05-07 |
NO20052710L (no) | 2005-06-06 |
NZ539599A (en) | 2007-06-29 |
MA27411A1 (fr) | 2005-06-01 |
CY1105752T1 (el) | 2010-12-22 |
EP1558612B1 (fr) | 2006-08-23 |
FR2846656B1 (fr) | 2004-12-24 |
AU2003292323A1 (en) | 2004-06-03 |
HK1081964A1 (en) | 2006-05-26 |
KR20050084663A (ko) | 2005-08-26 |
CN100335480C (zh) | 2007-09-05 |
AR041882A1 (es) | 2005-06-01 |
EA200500717A1 (ru) | 2005-10-27 |
US20060069117A1 (en) | 2006-03-30 |
MY135191A (en) | 2008-02-29 |
EA008446B1 (ru) | 2007-06-29 |
UA80579C2 (en) | 2007-10-10 |
PT1558612E (pt) | 2006-12-29 |
CN1711261A (zh) | 2005-12-21 |
JP2006508111A (ja) | 2006-03-09 |
KR100717488B1 (ko) | 2007-05-14 |
DE60307875D1 (de) | 2006-10-05 |
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