WO2003013972A1 - Bouchon de fermeture destine a des flacons de perfusion ou de transfusion - Google Patents

Bouchon de fermeture destine a des flacons de perfusion ou de transfusion Download PDF

Info

Publication number
WO2003013972A1
WO2003013972A1 PCT/EP2002/007452 EP0207452W WO03013972A1 WO 2003013972 A1 WO2003013972 A1 WO 2003013972A1 EP 0207452 W EP0207452 W EP 0207452W WO 03013972 A1 WO03013972 A1 WO 03013972A1
Authority
WO
WIPO (PCT)
Prior art keywords
closure cap
cap
overcap
closure
cover
Prior art date
Application number
PCT/EP2002/007452
Other languages
German (de)
English (en)
Inventor
Albert Louis Victor Jozef Claessens
Original Assignee
Helvoet Pharma Belgium N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helvoet Pharma Belgium N.V. filed Critical Helvoet Pharma Belgium N.V.
Priority to US10/484,488 priority Critical patent/US20040217082A1/en
Priority to JP2003518933A priority patent/JP2004536686A/ja
Priority to DE50207315T priority patent/DE50207315D1/de
Priority to EP02754832A priority patent/EP1412261B1/fr
Publication of WO2003013972A1 publication Critical patent/WO2003013972A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0015—Upper closure of the 41-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/009—Lower closure of the 51-type

Definitions

  • the invention relates to a closure cap for infusion or transfection bottles, with a rubber-like sealing part adapted to the bottle neck, wherein the Ner gleich cap is formed on the bottle neck to form a bead-engaging grip and furthermore an overcap is provided for form-fitting retention of the Ner gleich cap on bottleneck.
  • DE 4015 510 AI proposes to hold the sealing cap captivating the sealing part in the bulge under the bottle neck and to secure this under-grip by an overcap in the form of a form-fitting holder.
  • the overcap acts like a ripe. It is implemented as a ring slide that can be moved downwards beyond the top of the sealing cap. Knowing these requirements, the invention has set itself the task of forming a generic closure with a view to obtaining an assembly unit that is advantageous in terms of association and accessible for treatment.
  • the reversible locking position defining the distance has, as it were, a response threshold which only releases the further assembly stroke of the overcap when the undercutting grip on the closure cap on the bottle neck has taken place.
  • An abutment is built on. As already indicated, the wall lowers like a locking bolt over the anchoring zone of the closure cap.
  • closure cap and the sealing part are manufactured in a two-component injection molding process.
  • the adhesive force to be gained or set from this was found to be sufficient; in any case, the usual mechanical stresses, for example in the context of the sterilization explained above, the transport, the passage of the filling paths, the migration in sorting sections, etc. are not sufficient.
  • the assignment can also be such that a deliberate solution is opened, for example, to separate them according to type.
  • the closure cap is preferably injection molded over the relatively soft, preformed sealing part.
  • the sealing part is under elastic tension against the sealing cap due to shrinkage.
  • the cap base which is formed, and also with regard to the perforation-shaped piercing areas, which are also slightly narrower as part of the overall shrinkage.
  • this also leads to a welcome clamping hold towards the shaping section of the sealing part.
  • the closure cap has tongues in the circumferential direction that are formed like a segment of a circle and provided with a latching bead, which have outside latching configurations for latching the overcap that has corresponding latching projections on a cylinder wall.
  • the lower gripping tongues they are single tongues.
  • the structure is based on a zigzag to sawtooth-shaped structure.
  • the invention brings further in proposal that the cylinder wall of the overcap has a latching lug protruding beyond the latching projections of the cylinder wall at its lower, free end for the latching engagement of the closure cap. This brings a thickening of the edge of the cap there and thus a stable back support for the second, basically irreversible locking position of the closure.
  • the sealing cap assigned to a sealing cap cover, has a latching shape for reversible latching with the latching lug of the overcap.
  • the design of the latching shape creates the greatest possible free space for sterilization with regard to the preassembled unit.
  • the latching shape is arranged in a cross section below the top of the sealing cap, ie close to the ceiling.
  • the overcap has a top cap blanket over the piercing area.
  • the accessibility of the piercing area required in use results from simple means in that a tear-open tab extending to the outer edge of the cap cap is formed in the top cap blanket by a line of weakness.
  • the peripheral gripping attachment generally has a separation point here, which advantageously forms the access for the interior of the unit in advance.
  • two diametrically opposed tear tabs each extending to a central region of the overcap top are formed.
  • a tear-open tab is assigned to a piercing area which is peripherally surrounded by the cover cap cover.
  • the piercing areas are so to speak arranged in an island-like manner in the ceiling field.
  • the overcap is secured against rotation on the closure cap.
  • features that are provided can be included from the start. This is concretized in that the rotation lock is achieved by vertical ribs formed on the inside of the cylinder wall of the overcap, which engage in corresponding vertical grooves of the closure cap. In terms of the vertical grooves are the indicated specifications.
  • the relevant embodiment is characterized in that a vertical groove on the closure cap is formed by the separation area between two circular segment-like gripping tongues.
  • an advantageous embodiment consists in the vertical groove continuing up to the top of the cover cap, leaving a residue of the wall of the cover cap. The remainder is the result of a weakly frustoconical transition from the wall of the sealing cap to the sealing cap ceiling.
  • an advantageous variant of the subject matter of the invention is that the sealing element ends at a radial distance from the inside of the ring wall of the closure cap. Such a peripheral, circumferential annular gap can easily be taken into account in terms of production technology. The contact-free assignment to the inside there can be used if the explained clamping voltage is not to be used in this area and the mutual adhesive surfaces are to be minimized.
  • the radial distance that extends to the top of the sealing cap can be used to pry out the sealing part for the purpose of separation.
  • the sealing part can be pried out of the shell like an oyster.
  • FIG. 1 shows the closure according to the invention, assigned to a bottle neck, in an enlarged representation, namely in half section,
  • FIG. 3 is an illustration like FIG. 2, but broken away, 4 detached pull tabs of the closure, one of them in longitudinal section, again in a diagrammatic representation,
  • FIG. 13 shows a variant of the closure with a central piercing area in the position according to FIG. 12, but with the bottle neck not shown,
  • FIG. 15 shows a further variant of the closure in a representation like FIG. 1.
  • the non-metallic closure V shown consists of a nested double cap with a sealing part 1 held therein.
  • the sealing part 1 consists of thermoplastic rubber (TPE) and is basically disk-shaped. Its edge 2 is thickened against a bottle neck 3.
  • TPE thermoplastic rubber
  • a bottle 4 that can be used as an infusion or transfusion bottle consists of glass.
  • the free end of the bottle neck 3 widens radially outward into a bead 5. This provides an undercut flank 6. This serves to undercut through the actual closure cap 7 of the closure V.
  • the overcap covering it (7) bears the reference symbol 8.
  • the end face 9 widened by the bead 5 is designed in a rotationally symmetrical sloping roof-like manner.
  • the longer flank of the sloping roof slopes outwards.
  • the gable is convexly rounded with a connection to the mouth 10 of the bottle neck 3, a shorter, steeply falling flank.
  • the underside of the sealing part 1 facing the mouth 10 is recessed flat.
  • the depression bears the reference number 11.
  • the sealing cap 7 made of tough-hard plastic (PP), like the material-like overcap 8, is cup-shaped.
  • the former hires that Sealing part 1 on the outside surrounding shell part, consisting of a cover cap cover 12 which is essentially planar in the center. It merges into an annular wall 13. Ceiling 12 and ring wall 13 adjoin each other at an angle of over 90 °; in relation to the corner as a vertex, this angle includes approx. 110 °.
  • the approach is marked with a and the part with b. They are of the same leg length.
  • the ring wall 13 continues towards its free, lower end in lower gripping tongues 14. Following the circumferential direction of the closure cap 7, it is a ring of individual tongues which can be rebounded in the manner of a segment of a circle and have excellent restoring force. The curve also has a stabilizing effect.
  • the gripping means is specifically an identically formed locking bead 15 exposed on the bottle neck side. These locking beads 15 are anchored under the undercut flank 6 of the bottle neck 3. The flanks of parts 6 and 15 are matched to one another. They extend approximately at an angle of approx. 40 ° outwards to a horizontal.
  • the individual gripping tongues 14 freely cutting separation areas are realized as longitudinal slots 16 of the annular wall 13.
  • the slot base 16 of the longitudinal slots 16 is approximately level with the exposed ridge of the end face 9 of the bottle neck 3.
  • the cap cover 12 leaves puncturable areas.
  • the corresponding piercing area 17 lies in the center of the closure V, in the form of a circular hole 18, the radius point of which intersects the longitudinal central axis xx of the closure V, which is basically rotationally symmetrical.
  • the central piercing area is embodied in the version shown from FIG. 9. Otherwise, the structure is identical to the basic version, starting with Fig. 1.
  • the reference numerals are used analogously, sometimes without repeating textiles.
  • the basic version as can be clearly seen from FIG. 6, provides two such piercing areas 17 in the cover cap cover 12.
  • the sealing part 1 projects into the respective hole 18 circumscribing the piercing area 17 with a proportion of rubber-like substance that leads to the cavity.
  • the hole 18 can, however, also be closed by a correspondingly protruding projection protruding from the bottom or inside of the ceiling 19 of the overcap 8 into the opening or the hole 18.
  • the sealing part 1 does not have the disk-like filling bodies 20 arranged on its outside.
  • the sealing part 1 is caught on the sealing cap 7, the sealing part 1 being exposed to the outside of the sealing cap 7 in the circumference of the piercing area 17.
  • Exposed means or includes, leaving a practicable pierceability, so that a cuticle remaining on the top is still to be understood functionally under this term.
  • Sealing cap 7 and sealing part 1 are produced in a two-component injection molding process.
  • the prefabricated, relatively softer injection molded sealing part 1 is introduced with a shape into the injection / casting mold and overmolded with the relatively harder material that results in the closure cap 7. It comes here to the mentioned catching of the parts 1, 7 to one another, the adhesion of the masses to one another being adjusted such that the sealing part 1 can be released without adhering to the self-supporting hard body, that is to say the closure cap 7.
  • the surprising effect of a mechanical cohesion of the parts 1, 7 also occurs, specifically because of the shrinkage of the pot-forming material or part applied to the sealing part 1, so that the closure cap 7 is under elastic prestress against the sealing part 1 stands or vice versa.
  • the outer edges of the disk-shaped sealing part 1 are edge-clamped by the shell-forming region of the ring wall 13, that is to say the attachment a.
  • the sealing cap 7 thus equipped with the sealing part is combined with the overcap 8 by prepositioning (see FIG. 9).
  • This docking position is defined by a first, reversible locking position with an axial distance y remaining between the inside of the cover 19 of the overcap 8 and the top side of the closure cap cover 12 which has the piercing areas 17.
  • This first, reversible locking position is shown in the drawing I specified.
  • a unit 1/7/8 assembled in this way is immune to the usual mechanical loads, ie this preassembled unit can be conveyed and sorted, but above all, if necessary, can be fed to the usual sterilization processes. External and internal accessibility is ensured in the largest possible way. ben, because on the one hand the parts 7 and 8 are not yet nested and, moreover, leave the space at a distance y attainable via the openings 21 left in the area of the cap cap 12 under tear-off tabs 22.
  • the distance y defined by detenting leaves the lower gripping tongues 14 free-standing and fully reboundable.
  • the closure V is placed on the bottle neck 3. Due to the assignment pressure from above, the springing-out lower gripping tongues 14 overlap the bead 5 of the bottle neck 3, which has a larger cross section, until finally the locking beads 15 undercut the undercut surface 6.
  • the latching force holding the parts 7 and 8 at a distance y is set with respect to an insurmountable threshold in such a way that the overcap 8 on the jacket wall of the closure cap 7 only continues to overflow after the described anchoring.
  • the procedure for the first, reversible latching position I is such that the closure cap 7 has a latching configuration 23. It is preferably located as a circumferential groove on the outside of the ring wall 13, namely lying close to the cover cap cover 12, more precisely through below a cross-sectional plane of the cover V occupied by the cover 12.
  • the corresponding counter-locking means provides a catch 24 on the inside of a cylinder wall 25 of the cup-shaped overcap 8.
  • the latch 24 snaps under an inclined locking flank 26 in the back of the latching bead 15.
  • the cylinder wall 23 surrounds the ring of under-gripping tongues 14 like a tire , which thus securely holds the cap V on the bottle neck 3 of the infusion or transfusion bottle.
  • This irreversible locking mechanism 8, which is secured by the body 8 which practically provides a slide ring Position is marked II. It looks like a flare, only without the means of plastic deformation.
  • the outside of the ring wall 13 and the inside of the cylinder wall 25 are roughened from the slot base 16 'of the longitudinal slots 16 to the locking lug 24. It is an orderly, form-fit roughening in the form of a horizontally oriented tooth structure. More specifically, this looks in detail in terms of construction in such a way that the closure cap 7 in the circumferential direction of the lower gripping tongues 14 designed in the manner of a segment of a circle has outside latching formations 27 in the form of depressions.
  • the washboard-like contour can be seen in detail in the drawings.
  • the locking projections 28 have a lower radially oriented standing height than the locking lugs 24.
  • tear-off tab or tear-off tabs 22 in the overcap cover 19 are tongue-shaped in outline.
  • the desired separation tear is favored by a line of weakness 29. It is a top-side, notch-valley-like trench guide, with the trench bottom leaving a fraction as a material bridge. In the area of the peripheral openings 21, even this area is broken, so that the marking can be carried out more easily.
  • a freely projecting end zone of the tear-off tabs 22 also has a positive effect. The projection does not need to go beyond the general diameter of the overcap 8 if, as shown, the jacket wall of the latter is flattened in this end region.
  • the corresponding sub-groove has the reference symbol 30.
  • a tear-open tab 22 is assigned to a piercing area 17 which is peripherally surrounded by the cover cap cover 12.
  • the overcap 8 is held in a rotationally secured manner on the closure cap 7, which of course does not require such a measure in the case of a centrally located piercing area 17 of the closure V and a diametrically continuous tear-open tab 22.
  • the rotation lock is achieved by a vertical rib 31 formed on the inside of the cylinder wall 25 of the overcap 8. It projects beyond the height of the locking projections 28 and extends into the cross-sectional area of the ring wall 13 of the closure cap, more precisely into the cross-sectional area of the longitudinal slots 16.
  • a total of eight locking engagement spaces 16/32 distributed at equal angles are taken into account, two of which are occupied diametrically opposite one another by vertical ribs 31.
  • the spatial assignment of the holes 18 to the locking engagement spaces is such that the desired full coverage of the holes 18 is provided by the tear-off tabs 32 that overlap them.
  • the correct plug alignment can be practically felt by a slight rotary movement of the overcap 8 towards the closure cap 7.
  • the unused locking intervention rooms 16/32 can also be locked on the input side. In the case of a centrally located hole 19, however, such a precaution is not necessary.
  • the different embodiment consists in that the essentially disk-shaped sealing element 1 now ends peripherally with a radial distance z from the inside of the ring wall 13 of the closure cap 7.
  • the essentially cylindrical edge 35 of the sealing element 1 stands in contact-free manner in front of the inner side 36 of the ring wall 13 which circumscribes it.
  • the fully circumferential annular gap thus formed bears the reference number 37.
  • the annular gap 37 is only rudimentary. It extends only over a fraction of the shell-forming, vertical length of the ring wall 13, to be precise shortly behind the longitudinal slot base 16 '.
  • the said annular gap 37 tapers towards the ceiling-side gap base.
  • This bottom of the gap is provided in part by the other part of the closure cap 7, designated by b.
  • the bottom of the slot is recognizable as a non-contact zone between sealing part 1 and ring wall 13 or ceiling 12.
  • the annular gap 37 can be used in the sense that it forms a clamping lock between the sealing part 1 and the closure cap 7.
  • the annular gap 37 is dimensioned in the radial direction so that it does not clog after the shrinkage process described. This leaves an access for the attachment of a removal tool, for example in the sense of a desired sorting of the parts forming the closure V. On the other hand, however, there is also a certain radially inward deflection clearance with regard to the latching shape 23 of the closure cap 7.
  • the means are applied as explained above. If, in a modification of the piercing area described, the hole 18 is not to be occupied by a filler 20 of the sealing part 1, in return, one can proceed in such a way that a corresponding one from the overcap cover 19 or, as shown, from the underside of the tear-off tab 22 Go out the lead that occupies the hole.
  • a projection can of course be cylindrical or frustoconical.
  • the hole 18 is then designed to be adapted, ie funnel-shaped. In the back of the protrusion provided by the overcap 8, this can have an indentation from the top.
  • the correct hole finding is ensured in any case by the described angle-defining means, such as vertical rib 31 and vertical groove 32.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un bouchon de fermeture (V) destiné à des flacons de perfusion ou de transfusion, comportant un élément d'étanchéité (1) de type caoutchouc adapté au goulot du flacon (3). Ledit bouchon de fermeture présente un renflement (5) entrant en prise avec un talon sur le goulot (3), et un bouchon supérieur (8) sert à maintenir mécaniquement le bouchon de fermeture (7) sur le goulot (3). L'invention vise à mettre en oeuvre un tel flacon se présentant notamment sous une forme avantageuse pour la stérilisation. A cet effet, l'élément d'étanchéité (1) est saisi sur le bouchon de fermeture (7), l'élément d'étanchéité (1) présente une zone libre dans une zone de pénétration (17) en direction de l'extérieur du bouchon de fermeture (7), et le bouchon supérieur (8) recouvrant également la zone de pénétration (17) peut être fixé au bouchon de fermeture (7) dans une première position d'encastrage réversible (I) à distance axiale (y) de la zone de pénétration (17).
PCT/EP2002/007452 2001-08-03 2002-07-05 Bouchon de fermeture destine a des flacons de perfusion ou de transfusion WO2003013972A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/484,488 US20040217082A1 (en) 2001-08-03 2002-07-05 Closure cap for infusion or transfusion bottles
JP2003518933A JP2004536686A (ja) 2001-08-03 2002-07-05 点滴または輸血用ビンの栓キャップ
DE50207315T DE50207315D1 (de) 2001-08-03 2002-07-05 Verschlusskappe für infusions- oder transfusionsflaschen
EP02754832A EP1412261B1 (fr) 2001-08-03 2002-07-05 Bouchon de fermeture destine a des flacons de perfusion ou de transfusion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001138191 DE10138191B4 (de) 2001-08-03 2001-08-03 Verschluss für Infusions- oder Transfusionsflaschen
DE10138191.3 2001-08-03

Publications (1)

Publication Number Publication Date
WO2003013972A1 true WO2003013972A1 (fr) 2003-02-20

Family

ID=7694313

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007452 WO2003013972A1 (fr) 2001-08-03 2002-07-05 Bouchon de fermeture destine a des flacons de perfusion ou de transfusion

Country Status (6)

Country Link
US (1) US20040217082A1 (fr)
EP (1) EP1412261B1 (fr)
JP (1) JP2004536686A (fr)
CN (1) CN1274561C (fr)
DE (2) DE10138191B4 (fr)
WO (1) WO2003013972A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018526A1 (fr) * 2003-08-25 2005-03-03 Santen Pharmaceutical Co., Ltd. Bouchon a element de liberation, et contenant pour le stockage de medicaments
WO2007101840A1 (fr) * 2006-03-07 2007-09-13 Glaxosmithkline Biologicals Sa Flacon de médicaments
EP1955964A1 (fr) 2007-01-24 2008-08-13 Obrist Closures Switzerland GmbH Fermeture perforable
WO2012143338A1 (fr) * 2011-04-20 2012-10-26 Datwyler Pharma Packaging Belgium Nv Capuchon de fermeture
EP2433609A3 (fr) * 2010-09-22 2013-05-22 Deutsche Gesellschaft für Humanplasma mbH Bouteille de collecte de plasma sanguin
EP2136862A4 (fr) * 2007-04-19 2017-11-29 B. Braun Melsungen AG Contenant de stockage
WO2018065596A1 (fr) * 2016-10-08 2018-04-12 Fresenius Kabi Deutschland Gmbh Connecteur conçu pour un moyen d'emballage médical renfermant un liquide

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10311154A1 (de) * 2003-03-14 2004-09-23 Helvoet Pharma Belgium N.V. Für pharmazeutische Verwendung dienende Überkappe mit Verschlussstopfen
WO2008046419A1 (fr) * 2006-10-18 2008-04-24 Pbi-Dansensor A/S Dispositif destiné à être utilisé pour tester l'imperméabilité de contenants
DE102007058349A1 (de) * 2007-06-29 2009-01-02 Merck Patent Gmbh Verschluss
DE102008060995A1 (de) * 2008-12-09 2010-06-10 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Verschluss für ein Medikamentenbehältnis
US8295015B2 (en) * 2009-02-06 2012-10-23 Tdk Corporation Magnetoresistive element, thin film magnetic head, magnetic head slider, head gimbal assembly, head arm assembly and magnetic disk device
JP5594888B2 (ja) * 2010-10-27 2014-09-24 内外化成株式会社 医療用キャップ及びその製造方法
JP5896632B2 (ja) * 2011-07-05 2016-03-30 三笠産業株式会社 医療用キャップの製造方法
FR2986782B1 (fr) * 2012-02-13 2014-03-07 Raymond A & Cie Dispositif de verrouillage de bouchon sur recipient a collerette, recipient a collerette obture par bouchon pourvu d'un tel dispositif de verrouillage
CN103057829B (zh) * 2013-01-31 2014-11-05 浙江凌大包装有限公司 一种酒瓶的密封装置
EP2826458A1 (fr) * 2013-07-17 2015-01-21 F.Hoffmann-La Roche Ag Capuchon pour ampoule
CN105343978A (zh) * 2015-10-20 2016-02-24 江苏苏云医疗器材有限公司 一次性使用热湿交换器
IT201700020789A1 (it) * 2017-02-23 2018-08-23 Brev Angela Srl Dispositivo di chiusura a tenuta stagna per contenitore asettico e procedimento per la sua realizzazione
US10527171B2 (en) * 2017-08-15 2020-01-07 Cellular Research, Inc. Gasket
CN109911422B (zh) * 2019-04-02 2023-01-17 沁馨园(广州)生物科技有限公司 一种二元包装喷雾瓶
CA3138450A1 (fr) * 2019-05-03 2020-11-12 Janssen Biotech, Inc. Flacons et ensembles flacons a basse temperature
WO2023031586A1 (fr) * 2021-09-03 2023-03-09 Nicoventures Trading Limited Article de recharge et appareil de recharge

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269429A (en) * 1990-05-15 1993-12-14 Robert Finke Gmbh & Co. Kg Closure cap for infusion or transfusion bottles
EP0721896A1 (fr) * 1995-01-10 1996-07-17 Pohl GmbH & Co. KG Agencement sur poches à perfusion ou similaires
EP0837008A1 (fr) * 1996-04-09 1998-04-22 Taisei Kako Co., Ltd., Couvercle de recipient pour medicaments en forme de couronne
US6006932A (en) * 1996-02-29 1999-12-28 Bormioli Rocco & Figlio S.P.A. Capsule for security closure of containers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3715175C1 (de) * 1987-05-07 1988-11-24 Pohl Metall Kunststoff Verschlusskappe fuer Infusions- und Transfusionsflaschen
US5332113A (en) * 1989-11-30 1994-07-26 Elan Pharmaceutical Research Corporation Cap assembly
DE4015510A1 (de) * 1990-05-15 1991-11-21 Finke Robert Gmbh Verschlusskappe fuer infusions- oder transfusionsflaschen
FR2663291A1 (fr) * 1990-06-15 1991-12-20 Oreal Procede pour le conditionnement d'un produit dans un flacon, permettant d'assurer une meilleure conservation du produit au cours du stockage et ensemble de conditionnement correspondant.
DE4132896C1 (fr) * 1991-10-04 1993-01-21 Pohl Gmbh & Co Kg, 7500 Karlsruhe, De
US5314084A (en) * 1992-08-21 1994-05-24 The West Company, Incorporated Two piece all plastic seal
DE4228090C2 (de) * 1992-08-24 1995-01-05 Pohl Gmbh & Co Kg Verschluß für eine Flasche
US5494170A (en) * 1993-05-06 1996-02-27 Becton Dickinson And Company Combination stopper-shield closure
DE4446182A1 (de) * 1994-12-23 1996-06-27 Hali Handels Und Lizenzverwert Verschluß an Flaschen für Injektionsflüssigkeiten oder dergleichen
DE19500460A1 (de) * 1995-01-10 1996-07-11 Pohl Gmbh & Co Kg Anordnung an Infusionsflaschen oder dergleichen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269429A (en) * 1990-05-15 1993-12-14 Robert Finke Gmbh & Co. Kg Closure cap for infusion or transfusion bottles
EP0721896A1 (fr) * 1995-01-10 1996-07-17 Pohl GmbH & Co. KG Agencement sur poches à perfusion ou similaires
US6006932A (en) * 1996-02-29 1999-12-28 Bormioli Rocco & Figlio S.P.A. Capsule for security closure of containers
EP0837008A1 (fr) * 1996-04-09 1998-04-22 Taisei Kako Co., Ltd., Couvercle de recipient pour medicaments en forme de couronne

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018526A1 (fr) * 2003-08-25 2005-03-03 Santen Pharmaceutical Co., Ltd. Bouchon a element de liberation, et contenant pour le stockage de medicaments
WO2007101840A1 (fr) * 2006-03-07 2007-09-13 Glaxosmithkline Biologicals Sa Flacon de médicaments
EP1955964A1 (fr) 2007-01-24 2008-08-13 Obrist Closures Switzerland GmbH Fermeture perforable
EP2136862A4 (fr) * 2007-04-19 2017-11-29 B. Braun Melsungen AG Contenant de stockage
EP2433609A3 (fr) * 2010-09-22 2013-05-22 Deutsche Gesellschaft für Humanplasma mbH Bouteille de collecte de plasma sanguin
WO2012143338A1 (fr) * 2011-04-20 2012-10-26 Datwyler Pharma Packaging Belgium Nv Capuchon de fermeture
US9265696B2 (en) 2011-04-20 2016-02-23 Datwyler Pharma Packaging Belgium Nv Closure cap
WO2018065596A1 (fr) * 2016-10-08 2018-04-12 Fresenius Kabi Deutschland Gmbh Connecteur conçu pour un moyen d'emballage médical renfermant un liquide
US11464707B2 (en) 2016-10-08 2022-10-11 Fresenius Kabi Deutschland Gmbh Connector for a medical package containing a liquid

Also Published As

Publication number Publication date
EP1412261B1 (fr) 2006-06-21
DE50207315D1 (de) 2006-08-03
CN1274561C (zh) 2006-09-13
EP1412261A1 (fr) 2004-04-28
US20040217082A1 (en) 2004-11-04
DE10138191A1 (de) 2003-02-27
DE10138191B4 (de) 2004-02-26
CN1538925A (zh) 2004-10-20
JP2004536686A (ja) 2004-12-09

Similar Documents

Publication Publication Date Title
WO2003013972A1 (fr) Bouchon de fermeture destine a des flacons de perfusion ou de transfusion
EP1951343B1 (fr) Chapeau pour une seringue ou pour une carpule
DE60019446T2 (de) Flüssigkeitstransferset für phiolen und andere medizinische behälter
DE69030378T2 (de) Spenderverschluss
DE4314923C2 (de) Verschlußkappe zum Verschließen einer Flasche
DE2356007C2 (de) Mißbrauchsicherer Schraubverschluß
EP0049876A1 (fr) Bouchon à vis inviolable
WO1989009736A1 (fr) Recipient a deux cavites
EP2680909A1 (fr) Bouchon et procédé de fabrication dudit bouchon
DE3204592A1 (de) Schraubkapsel mit sicherheitshaltering
EP1926669A1 (fr) Fermeture a vis inviolable destinee a des recipients et des bouteilles, en particulier des bouteilles en plastique
DE10007367A1 (de) Verschlusskappe für Infusions- und Transfusionsflaschen
EP0721897A1 (fr) Dispositif pour bouteilles d'infusion ou similaire
DE2142297C2 (de) Gegen unbefugtes Öffnen gesicherter Verschluß für Behälter
EP1003681B1 (fr) Reservoir a deux composantes
EP2569225A1 (fr) Fermeture pour un récipient et procédé pour mettre en uvre un procédé de cryodessication
DE102013007063A1 (de) Behältnis
DE102009055861B4 (de) Abdeckung von Schraubenbohrungen
DE202010004680U1 (de) Allseitig geschlossene Verschlusskappe mit Ausgießer
DE102010034856B4 (de) Arretierbare Betätigungsvorrichtung für ein Dosiersystem eines Behältnisses
EP0498954B1 (fr) Capuchon de fermeture pour fermeture en matière plastique
EP0592700B1 (fr) Récipient d'épice
EP3704032A2 (fr) Récipient
WO2023099546A1 (fr) Récipient pour médicaments
DE4204977A1 (de) Kindersicherheitsverschluss

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003518933

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 20028152565

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2002754832

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002754832

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10484488

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2002754832

Country of ref document: EP