WO2003011911A1 - Substance specifique pour pd-1 - Google Patents

Substance specifique pour pd-1 Download PDF

Info

Publication number
WO2003011911A1
WO2003011911A1 PCT/JP2002/007735 JP0207735W WO03011911A1 WO 2003011911 A1 WO2003011911 A1 WO 2003011911A1 JP 0207735 W JP0207735 W JP 0207735W WO 03011911 A1 WO03011911 A1 WO 03011911A1
Authority
WO
WIPO (PCT)
Prior art keywords
pd
substance
membrane
substance specific
expressed
Prior art date
Application number
PCT/JP2002/007735
Other languages
English (en)
French (fr)
Inventor
Tasuku Honjo
Shiro Shibayama
Masayoshi Matsuo
Takao Yoshida
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001-232303 priority Critical
Priority to JP2001232303 priority
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of WO2003011911A1 publication Critical patent/WO2003011911A1/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
PCT/JP2002/007735 2001-07-31 2002-07-30 Substance specifique pour pd-1 WO2003011911A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2001-232303 2001-07-31
JP2001232303 2001-07-31

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2003517101A JP4249013B2 (ja) 2001-07-31 2002-07-30 Pd−1に対し特異性を有する物質
EP20020755688 EP1445264B1 (en) 2001-07-31 2002-07-30 Substance specific to pd-1
AT02755688T AT524495T (de) 2001-07-31 2002-07-30 Pd-1-spezifische substanz
US10/485,466 US20040241745A1 (en) 2001-07-31 2002-07-30 Substance specific to pd-1
US12/057,637 US7858746B2 (en) 2001-07-31 2008-03-28 Substance that specifically recognizes PD-1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/057,637 Division US7858746B2 (en) 2001-07-31 2008-03-28 Substance that specifically recognizes PD-1

Publications (1)

Publication Number Publication Date
WO2003011911A1 true WO2003011911A1 (fr) 2003-02-13

Family

ID=19064242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007735 WO2003011911A1 (fr) 2001-07-31 2002-07-30 Substance specifique pour pd-1

Country Status (5)

Country Link
US (2) US20040241745A1 (ja)
EP (1) EP1445264B1 (ja)
JP (1) JP4249013B2 (ja)
AT (1) AT524495T (ja)
WO (1) WO2003011911A1 (ja)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004771A1 (ja) * 2002-07-03 2004-01-15 Ono Pharmaceutical Co., Ltd. 免疫賦活組成物
JP2006521783A (ja) * 2002-12-23 2006-09-28 ケンブリッジ アンティボディー テクノロジー リミテッド Pd−1に対する抗体およびその使用
WO2007122815A1 (ja) * 2006-04-14 2007-11-01 Ono Pharmaceutical Co., Ltd. Bir1に対する二価抗体
US8354509B2 (en) 2007-06-18 2013-01-15 Msd Oss B.V. Antibodies to human programmed death receptor PD-1
WO2013022091A1 (ja) 2011-08-11 2013-02-14 小野薬品工業株式会社 Pd-1アゴニストからなる自己免疫疾患治療剤
US8779105B2 (en) 2005-05-09 2014-07-15 Medarex, L.L.C. Monoclonal antibodies to programmed death 1 (PD-1)
US20160075782A1 (en) 2005-07-01 2016-03-17 E.R. Squibb & Sons, L. L. C. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
US9683048B2 (en) 2014-01-24 2017-06-20 Novartis Ag Antibody molecules to PD-1 and uses thereof
WO2017160754A1 (en) 2016-03-15 2017-09-21 Mersana Therapeutics,Inc. Napi2b-targeted antibody-drug conjugates and methods of use thereof
WO2018098269A2 (en) 2016-11-23 2018-05-31 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
WO2018160538A1 (en) 2017-02-28 2018-09-07 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
US10160806B2 (en) 2014-06-26 2018-12-25 Macrogenics, Inc. Covalently bonded diabodies having immunoreactivity with PD-1 and LAG-3, and methods of use thereof
WO2019104289A1 (en) 2017-11-27 2019-05-31 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
WO2019126691A1 (en) 2017-12-21 2019-06-27 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
WO2019156199A1 (ja) * 2018-02-09 2019-08-15 小野薬品工業株式会社 二重特異性抗体
US10472419B2 (en) 2014-01-31 2019-11-12 Novartis Ag Antibody molecules to TIM-3 and uses thereof

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
JP4532409B2 (ja) 2003-01-23 2010-08-25 小野薬品工業株式会社 ヒトpd−1に対し特異性を有する物質
AU2009241589B2 (en) 2008-04-29 2013-10-10 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
BRPI0913366A2 (pt) 2008-06-03 2015-11-24 Abbott Lab imunoglobulinas de domínio variável duplo e seus usos
BRPI0913406A2 (pt) 2008-06-03 2018-01-09 Abbott Lab imunoglobulinas de domínio variável duplo e usos das mesmas
WO2010006060A2 (en) 2008-07-08 2010-01-14 Abbott Laboratories Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
RU2017132160A (ru) 2008-12-09 2019-02-08 Дженентек, Инк. Антитела к pd-l1 и их применение для усиления функции t-клеток
AR078254A1 (es) * 2009-09-01 2011-10-26 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
UY32948A (es) * 2009-10-15 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
AU2011285852B2 (en) 2010-08-03 2014-12-11 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2012027570A2 (en) 2010-08-26 2012-03-01 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
US9205148B2 (en) 2011-04-20 2015-12-08 Medimmune, Llc Antibodies and other molecules that bind B7-H1 and PD-1
CN104159920A (zh) 2011-12-30 2014-11-19 艾伯维公司 针对il-13和/或il-17的双重可变结构域免疫球蛋白
MX2015005593A (es) 2012-11-01 2016-02-05 Abbvie Inc Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas.
RU2019103572A (ru) 2013-02-26 2019-06-24 Мемориал Слоан-Кеттеринг Кэнсер Сентер Композиции и способы иммунотерапии
BR112015023797A2 (pt) 2013-03-15 2017-10-24 Abbvie Inc proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17
AU2014259719B2 (en) 2013-05-02 2019-10-03 Anaptysbio, Inc. Antibodies directed against programmed death-1 (PD-1)
WO2014194293A1 (en) 2013-05-30 2014-12-04 Amplimmune, Inc. Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
KR20170002403A (ko) * 2014-05-01 2017-01-06 가부시키가이샤 아네로파마·사이엔스 이종 폴리펩티드 발현 카세트
CN105085680A (zh) * 2014-05-23 2015-11-25 复旦大学 人源化抗PD-1及c-MET双特异性抗体及其制备方法和应用
EP3169341B1 (en) 2014-07-16 2019-06-05 Transgene SA Oncolytic virus for expression of immune checkpoint modulators
US9982053B2 (en) 2014-08-05 2018-05-29 MabQuest, SA Immunological reagents
US9982052B2 (en) 2014-08-05 2018-05-29 MabQuest, SA Immunological reagents
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
AU2016294440A1 (en) 2015-07-13 2018-02-22 Cytomx Therapeutics, Inc. Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof
MX2018001227A (es) 2015-07-30 2018-03-26 Macrogenics Inc Moleculas de union a pd-1 y metodos de uso de las mismas.
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
BR112018003186A2 (pt) 2015-09-01 2018-09-25 Agenus Inc anticorpos anti-pd-1 e seus métodos de uso
CN108289953A (zh) 2015-09-29 2018-07-17 细胞基因公司 Pd-1结合蛋白及其使用方法
EP3405497A2 (en) 2016-01-22 2018-11-28 Mabquest SA Immunological reagents
EP3420000A1 (en) 2016-02-25 2019-01-02 Cell Medica Switzerland AG Modified cells for immunotherapy
CN109789205A (zh) 2016-09-14 2019-05-21 艾伯维生物制药股份有限公司 抗pd-1(cd279)抗体

Citations (1)

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Publication number Priority date Publication date Assignee Title
JPH07291996A (ja) * 1994-03-01 1995-11-07 Yuu Honshiyo ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物

Family Cites Families (2)

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EP1210428B1 (en) * 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
AR036993A1 (es) * 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JPH07291996A (ja) * 1994-03-01 1995-11-07 Yuu Honshiyo ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FREEMAN G.J. ET AL.: "Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation", J. EXP. MED., vol. 192, no. 7, 2000, pages 1027 - 1034, XP002942545 *
NISHIMURA H. ET AL.: "Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses", INT. IMMUNOL., vol. 10, no. 10, 1998, pages 1563 - 1572, XP000971789 *
OKAZAKI T. ET AL.: "PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 24, 2001, pages 13866 - 13871, XP002957352 *
See also references of EP1445264A4 *

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8728474B2 (en) 2002-07-03 2014-05-20 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
US9439962B2 (en) 2002-07-03 2016-09-13 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
US9402899B2 (en) 2002-07-03 2016-08-02 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
US7595048B2 (en) 2002-07-03 2009-09-29 Ono Pharmaceutical Co., Ltd. Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
US9393301B2 (en) 2002-07-03 2016-07-19 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
US8168179B2 (en) 2002-07-03 2012-05-01 Ono Pharmaceutical Co., Ltd. Treatment method using anti-PD-L1 antibody
US9073994B2 (en) 2002-07-03 2015-07-07 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
US9067999B1 (en) 2002-07-03 2015-06-30 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
WO2004004771A1 (ja) * 2002-07-03 2004-01-15 Ono Pharmaceutical Co., Ltd. 免疫賦活組成物
JP2006521783A (ja) * 2002-12-23 2006-09-28 ケンブリッジ アンティボディー テクノロジー リミテッド Pd−1に対する抗体およびその使用
JP2010189395A (ja) * 2002-12-23 2010-09-02 Medimmune Ltd Pd−1に対する抗体およびその使用
US10441655B2 (en) 2005-05-09 2019-10-15 Ono Pharmaceutical Co., Ltd. Monoclonal antibodies to programmed death 1 (PD-1)
US9358289B2 (en) 2005-05-09 2016-06-07 Ono Pharmaceutical Co., Ltd. Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies
US8779105B2 (en) 2005-05-09 2014-07-15 Medarex, L.L.C. Monoclonal antibodies to programmed death 1 (PD-1)
US9492540B2 (en) 2005-05-09 2016-11-15 Ono Pharmaceutical Co., Ltd. Methods for treating cancer using anti-PD-1 antibodies
US9084776B2 (en) 2005-05-09 2015-07-21 E.R. Squibb & Sons, L.L.C. Methods for treating cancer using anti-PD-1 antibodies
US9387247B2 (en) 2005-05-09 2016-07-12 Ono Pharmaceutical Co., Ltd. Monoclonal antibodies to programmed death 1 (PD-1)
US9492539B2 (en) 2005-05-09 2016-11-15 Ono Pharmaceutical Co., Ltd. Monoclonal antibodies to Programmed Death 1 (PD-1)
US20160075782A1 (en) 2005-07-01 2016-03-17 E.R. Squibb & Sons, L. L. C. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
US9580507B2 (en) 2005-07-01 2017-02-28 E.R. Squibb & Sons, L. L. C. Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
US9580505B2 (en) 2005-07-01 2017-02-28 E.R. Squibb & Sons, L. L. C. Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
WO2007122815A1 (ja) * 2006-04-14 2007-11-01 Ono Pharmaceutical Co., Ltd. Bir1に対する二価抗体
US9834605B2 (en) 2007-06-18 2017-12-05 Merck Sharpe & Dohme B.V. Antibodies to human programmed death receptor PD-1
US8354509B2 (en) 2007-06-18 2013-01-15 Msd Oss B.V. Antibodies to human programmed death receptor PD-1
US8900587B2 (en) 2007-06-18 2014-12-02 Merck Sharp & Dohme Corp. Antibodies to human programmed death receptor PD-1
US8952136B2 (en) 2007-06-18 2015-02-10 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor PD-1
JP2017088617A (ja) * 2011-08-11 2017-05-25 小野薬品工業株式会社 Pd−1アゴニストからなる自己免疫疾患治療剤
US9701749B2 (en) 2011-08-11 2017-07-11 Ono Pharmaceutical Co., Ltd. Therapeutic agent for autoimmune diseases comprising PD-1 agonist
WO2013022091A1 (ja) 2011-08-11 2013-02-14 小野薬品工業株式会社 Pd-1アゴニストからなる自己免疫疾患治療剤
JPWO2013022091A1 (ja) * 2011-08-11 2015-03-05 小野薬品工業株式会社 Pd−1アゴニストからなる自己免疫疾患治療剤
US9683048B2 (en) 2014-01-24 2017-06-20 Novartis Ag Antibody molecules to PD-1 and uses thereof
US9815898B2 (en) 2014-01-24 2017-11-14 Novartis Ag Antibody molecules to PD-1 and uses thereof
US10472419B2 (en) 2014-01-31 2019-11-12 Novartis Ag Antibody molecules to TIM-3 and uses thereof
US10160806B2 (en) 2014-06-26 2018-12-25 Macrogenics, Inc. Covalently bonded diabodies having immunoreactivity with PD-1 and LAG-3, and methods of use thereof
WO2017160754A1 (en) 2016-03-15 2017-09-21 Mersana Therapeutics,Inc. Napi2b-targeted antibody-drug conjugates and methods of use thereof
WO2018098269A2 (en) 2016-11-23 2018-05-31 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
WO2018160538A1 (en) 2017-02-28 2018-09-07 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
WO2019104289A1 (en) 2017-11-27 2019-05-31 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
WO2019126691A1 (en) 2017-12-21 2019-06-27 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
WO2019156199A1 (ja) * 2018-02-09 2019-08-15 小野薬品工業株式会社 二重特異性抗体

Also Published As

Publication number Publication date
US20040241745A1 (en) 2004-12-02
EP1445264B1 (en) 2011-09-14
JPWO2003011911A1 (ja) 2004-11-18
EP1445264A4 (en) 2006-01-18
US7858746B2 (en) 2010-12-28
JP4249013B2 (ja) 2009-04-02
EP1445264A1 (en) 2004-08-11
AT524495T (de) 2011-09-15
US20090076250A1 (en) 2009-03-19

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