WO2002072802A3 - Live attenuated strains of prrs virus - Google Patents

Live attenuated strains of prrs virus Download PDF

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Publication number
WO2002072802A3
WO2002072802A3 PCT/EP2002/002486 EP0202486W WO02072802A3 WO 2002072802 A3 WO2002072802 A3 WO 2002072802A3 EP 0202486 W EP0202486 W EP 0202486W WO 02072802 A3 WO02072802 A3 WO 02072802A3
Authority
WO
WIPO (PCT)
Prior art keywords
viruses
live attenuated
prrs virus
prrs
attenuated strains
Prior art date
Application number
PCT/EP2002/002486
Other languages
English (en)
French (fr)
Other versions
WO2002072802A2 (en
Inventor
Knut Elbers
Stefan Peschke
Bettina Schuetz
Original Assignee
Boehringer Ingelheim Vetmed
Knut Elbers
Stefan Peschke
Bettina Schuetz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed, Knut Elbers, Stefan Peschke, Bettina Schuetz filed Critical Boehringer Ingelheim Vetmed
Priority to HU0303431A priority Critical patent/HUP0303431A2/hu
Priority to EP02726146A priority patent/EP1421184A2/en
Priority to CA002439254A priority patent/CA2439254A1/en
Priority to BR0207988-7A priority patent/BR0207988A/pt
Priority to MXPA03007751A priority patent/MXPA03007751A/es
Priority to KR10-2003-7011656A priority patent/KR20030082960A/ko
Priority to JP2002571858A priority patent/JP2004534522A/ja
Priority to SK1128-2003A priority patent/SK11282003A3/sk
Publication of WO2002072802A2 publication Critical patent/WO2002072802A2/en
Publication of WO2002072802A3 publication Critical patent/WO2002072802A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
PCT/EP2002/002486 2001-03-09 2002-03-07 Live attenuated strains of prrs virus WO2002072802A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
HU0303431A HUP0303431A2 (hu) 2001-03-09 2002-03-07 PRRS vírus élő legyengített törzsei
EP02726146A EP1421184A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus
CA002439254A CA2439254A1 (en) 2001-03-09 2002-03-07 Life attenuated strains of prrs virus
BR0207988-7A BR0207988A (pt) 2001-03-09 2002-03-07 Cepas atenuadas vivas de vìrus de prrs
MXPA03007751A MXPA03007751A (es) 2001-03-09 2002-03-07 Cepas vivas atenuadas del virus prrs.
KR10-2003-7011656A KR20030082960A (ko) 2001-03-09 2002-03-07 Ｐｒｒｓ 바이러스의 약독화된 생균 균주
JP2002571858A JP2004534522A (ja) 2001-03-09 2002-03-07 生きた弱毒化されたｐｒｒｓウイルス株
SK1128-2003A SK11282003A3 (sk) 2001-03-09 2002-03-07 Oslabený európsky PRRS vírus, nukleotidová sekvencia kódujúca vírus, spôsob generovania infekčného živého oslabeného PRRS vírusu, bunková línia a farmaceutický prostriedok s jeho obsahom a jeho použitie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27460301P 2001-03-09 2001-03-09
US60/274,603 2001-03-09

Publications (2)

Publication Number Publication Date
WO2002072802A2 WO2002072802A2 (en) 2002-09-19
WO2002072802A3 true WO2002072802A3 (en) 2004-03-11

Family

ID=23048885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002486 WO2002072802A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus

Country Status (12)

Country Link
EP (1) EP1421184A2 (en11)
JP (1) JP2004534522A (en11)
KR (1) KR20030082960A (en11)
BR (1) BR0207988A (en11)
CA (1) CA2439254A1 (en11)
CZ (1) CZ20032743A3 (en11)
HU (1) HUP0303431A2 (en11)
MX (1) MXPA03007751A (en11)
PL (1) PL370541A1 (en11)
RU (1) RU2003129068A (en11)
SK (1) SK11282003A3 (en11)
WO (1) WO2002072802A2 (en11)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1438969A1 (en) * 2003-01-14 2004-07-21 Universiteit Utrecht Arterivirus marker vaccine
KR20050040172A (ko) * 2003-10-27 2005-05-03 주식회사 중앙백신연구소 돼지 생식기호흡기 증후군 바이러스 불활화 백신의 제조방법
CA2587849A1 (en) * 2004-11-19 2006-05-26 Intervet International B.V. Porcine reproductive and respiratory syndrome virus strains and compositions
AU2006253891B2 (en) * 2005-02-25 2011-12-01 Zoetis P Llc N Protein Mutants of Porcine reproductive and respiratory syndrome virus
WO2009008924A2 (en) 2007-04-05 2009-01-15 Mount Sinai School Of Medicine Of New York University Methods of preventing and treating viral infections by inhibiting the deisgylation activity of otu domain-containing viral proteins
CN101454442A (zh) * 2007-06-15 2009-06-10 普泰克国际有限公司 嵌合体prrsv的构建，组合物及疫苗的制备
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
BR122021013826B1 (pt) * 2011-02-17 2022-11-22 Boehringer Ingelheim Vetmedica Gmbh Composição de proteína, ácido nucleico isolado e vetor de expressão recombinante
KR101420850B1 (ko) * 2011-05-30 2014-08-13 건국대학교 산학협력단 돼지 생식기 호흡기 증후군 바이러스 유사입자 및 이를 이용한 백신
KR101281361B1 (ko) * 2011-07-18 2013-07-02 서울대학교산학협력단 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물
KR101245029B1 (ko) * 2012-01-18 2013-03-18 서울대학교산학협력단 한국형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물
WO2013173443A1 (en) * 2012-05-17 2013-11-21 Zoetis Llc Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
CN103290142B (zh) * 2013-03-29 2015-03-11 云南农业大学 荧光定量rt-pcr检测猪蓝耳病弱毒疫苗病毒含量的方法
KR101624485B1 (ko) 2014-08-13 2016-05-26 전북대학교산학협력단 돼지생식기호흡기증후군 바이러스(prrsv) 변이주 및 이를 포함하는 돼지 생식기 호흡기 증후군 예방 또는 치료용 백신 조성물
CN104694561B (zh) * 2015-02-10 2018-02-23 中国农业科学院上海兽医研究所 表达海肾或萤火虫荧光素酶基因的prrsv重组质粒的构建方法以及应用
CN114502240A (zh) * 2019-08-29 2022-05-13 礼蓝美国公司 猪繁殖与呼吸综合征疫苗病毒
KR102276341B1 (ko) * 2020-01-29 2021-07-12 주식회사 바이오포아 유럽형 돼지 생식기 호흡기 증후군 바이러스의 제조 방법 및 이의 용도
EP4098741A4 (en) * 2020-01-29 2024-04-03 Biopoa Inc MUTANT STRAIN OF EUROPEAN SWINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, AND VACCINE USING SAME

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
WO1996006619A1 (en) * 1994-09-01 1996-03-07 Paul Prem S Polynucleic acids and proteins from a porcine reproductive and respiratory syndrome virus and uses thereof
WO1998050426A1 (en) * 1997-05-06 1998-11-12 Stichting Dienst Landbouwkundig Onderzoek Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
WO1998055626A2 (en) * 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
WO2001055353A2 (en) * 2000-01-26 2001-08-02 Boehringer Ingelheim Vetmedica Gmbh Recombinant attenuation of prrsv
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
WO2001089559A2 (en) * 2000-05-24 2001-11-29 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
WO2002095040A1 (en) * 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
WO1996006619A1 (en) * 1994-09-01 1996-03-07 Paul Prem S Polynucleic acids and proteins from a porcine reproductive and respiratory syndrome virus and uses thereof
WO1998050426A1 (en) * 1997-05-06 1998-11-12 Stichting Dienst Landbouwkundig Onderzoek Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
WO1998055626A2 (en) * 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
WO2001055353A2 (en) * 2000-01-26 2001-08-02 Boehringer Ingelheim Vetmedica Gmbh Recombinant attenuation of prrsv
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
WO2001089559A2 (en) * 2000-05-24 2001-11-29 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
WO2002095040A1 (en) * 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLENDE R ET AL: "Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype", ARCHIVES OF VIROLOGY, NEW YORK, NY, US, vol. 145, no. 6, June 2000 (2000-06-01), pages 1149 - 1161, XP000926571, ISSN: 0304-8608 *
YANG S X ET AL: "Comparative sequence analysis of open reading frames 2 to 7 of the modified live vaccine virus and other North American isolates of the porcine reproductive and respiratory syndrome virus", ARCHIVES OF VIROLOGY, NEW YORK, NY, US, vol. 143, no. 3, 1998, pages 601 - 612, XP000926565, ISSN: 0304-8608 *

Also Published As

Publication number Publication date
CZ20032743A3 (cs) 2004-02-18
CA2439254A1 (en) 2002-09-19
MXPA03007751A (es) 2004-11-12
WO2002072802A2 (en) 2002-09-19
KR20030082960A (ko) 2003-10-23
RU2003129068A (ru) 2005-04-10
JP2004534522A (ja) 2004-11-18
HUP0303431A2 (hu) 2004-01-28
PL370541A1 (en) 2005-05-30
EP1421184A2 (en) 2004-05-26
SK11282003A3 (sk) 2004-02-03
BR0207988A (pt) 2004-10-26

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