WO2002027284A1 - Appareil et procede de mesure optique - Google Patents
Appareil et procede de mesure optique Download PDFInfo
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- WO2002027284A1 WO2002027284A1 PCT/JP2000/006562 JP0006562W WO0227284A1 WO 2002027284 A1 WO2002027284 A1 WO 2002027284A1 JP 0006562 W JP0006562 W JP 0006562W WO 0227284 A1 WO0227284 A1 WO 0227284A1
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- 230000003287 optical effect Effects 0.000 title claims abstract description 82
- 238000005259 measurement Methods 0.000 title claims abstract description 62
- 238000000034 method Methods 0.000 title claims description 12
- 238000001514 detection method Methods 0.000 claims abstract description 46
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- 238000000691 measurement method Methods 0.000 claims description 9
- 239000004065 semiconductor Substances 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 4
- 230000010354 integration Effects 0.000 claims description 2
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
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- 230000003321 amplification Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
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- 101000985230 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Probable 4-hydroxyphenylpyruvate dioxygenase 2 Proteins 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
- G01J2001/4413—Type
- G01J2001/442—Single-photon detection or photon counting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
- G01J2001/4413—Type
- G01J2001/4433—Peak sensing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
- G01J2001/444—Compensating; Calibrating, e.g. dark current, temperature drift, noise reduction or baseline correction; Adjusting
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
- G01J2001/4446—Type of detector
- G01J2001/446—Photodiode
- G01J2001/4466—Avalanche
Definitions
- the present invention relates to an optical measurement device and an optical measurement method, and particularly to an optical measurement device and an optical measurement method for detecting photons.
- an optical measurement device includes: a photon detection unit that detects an incident photon; a time signal output unit that outputs a time signal; Storage means for storing the time signal output from the signal output means. By storing the time signal output from the time signal output means when the photon is detected by the photon detection means, it is possible to measure "when the photon has come”.
- the photon detecting means detects the number of incident photons
- the storing means detects the photons detected by the photon detecting means when the photons are detected by the photon detecting means. It is preferable to store the number and the time signal output from the time signal output means.
- the photon detection means has an AZD converter, and the A / D converter outputs the number of incident photons as a digital value.
- the signal output from the photon detection means can be directly stored by the storage means.
- the photon detecting means includes: a photoelectric surface that emits photoelectrons according to the number of incident photons; an accelerating device that accelerates the photons emitted from the photoelectric surface; And a semiconductor photodetector that injects photoelectrons accelerated by the laser beam and outputs an output signal corresponding to the number of photoelectrons.
- the number of photons incident simultaneously can be efficiently detected by using the photon detecting means provided with the photocathode, the acceleration means, and the semiconductor photodetector.
- a light measurement method of the present invention includes a photon detection step of detecting an incident photon, a time signal output step of outputting a time signal, and a photon detection step of detecting a photon. And a storage step of storing the time signal output in the time signal output step.
- the photon detecting step includes: In the storing step, when the photons are detected in the photon detecting step, the number of photons detected in the photon detecting step and the time signal output in the time signal outputting step are stored. storage is preferably c result that it is possible to measure the "or photon when coming" over time.
- FIG. 1 is a configuration diagram of an optical measurement device according to an embodiment of the present invention.
- Figure 2 (a) shows the output wave height distribution of HPD 24 for a multiphoton.
- FIG. 2 (b) is a diagram showing an output waveform of the TZ amplifier 26.
- FIGS. 3 (a) to 3 (h) are evening timing charts showing the operation of the optical measurement device of FIG.
- Fig. 3 (a) shows the incident timing of the photons
- Fig. 3 (b) shows the output of the TZ amplifier
- Fig. 3 (c) shows the output of the peak hold circuit
- FIG. 3 (d) shows a trigger signal from the A / D converter delay circuit 37
- FIG. 3 (e) shows a reset signal from the counter
- FIG. 3 (f) shows FIG. 3 (g) shows the output of the counter
- FIG. 3 (h) shows the data in the memory.
- FIGS. 4 (a) to 4 (c) are timing charts showing the effect of the optical measurement device of FIG. 1 in comparison with a comparative example.
- Fig. 4 (a) shows the incident timing of the photon
- Fig. 4 (b) shows the output of the digital oscilloscope in the comparative example
- Fig. 4 (c) shows the optical measurement device. Indicates an output of
- FIG. 5 is a configuration diagram of an optical measurement device according to a first modification of the embodiment of the present invention.
- FIG. 6 (a) to 6 (h) are evening timing charts showing the operation of the optical measuring device in FIG.
- Fig. 6 (a) shows the incident time of the incident photon
- Fig. 6 (b) shows the output of the TZ amplifier
- Fig. 6 (c) shows the output of the peak hold circuit.
- FIG. 6 (d) shows a trigger signal from the A / D converter delay circuit 37
- FIG. 6 (e) shows a reset signal from the delay circuit 29
- FIG. 6 (f) The figure shows the output of the A / D converter
- Figure 6 (g) shows the output of the counter
- Figure 6 (h) shows the data in memory.
- FIG. 7 is a configuration diagram of an optical measurement device according to a second modification of the embodiment of the present invention.
- FIG. 8 (a) to 8 (h) are evening timing charts showing the operation of the optical measurement device in FIG.
- Fig. 8 (a) shows the timing of the photon incidence
- Fig. 8 (b) shows the readout signal from the counter
- Fig. 8 (c) shows the reset from the countdown.
- 8 (d) shows the output of the charge amplifier
- FIG. 8 (e) shows the trigger signal from the comparator 36
- FIG. 8 (f) shows the output of the AZD converter.
- Figure 8 (g) shows the output of the counter
- Figure 8 () shows the data in memory.
- FIG. 9 shows a configuration of an optical measurement device according to a third modification of the embodiment of the present invention.
- FIG. 1 is a configuration diagram of an optical measurement device according to the present embodiment.
- the optical measurement device 10 includes a photon detection unit 12 that detects an incident photon, a time signal output unit 14 that outputs a time signal, and a time signal output when a photon is detected by the photon detection unit 12. It has a storage section 16 for storing the time signal output from the section 14, a CPU 18 for controlling the entire apparatus, an external memory 20 for storing set values, etc., and a display section 22 for displaying measurement results and the like. You. Hereinafter, each component will be described in detail.
- Photon detector 1 2 hybrid photodetector hereinafter, referred to as HPD 2 4
- a transimpedance amplifier hereinafter, TZ amplifier 26 intends gutter
- c configured with a peak hold circuit 28 and A / D converter 30
- the HPD 24 is an avalanche photodiode that is a semiconductor photodetector that outputs an output signal according to the number of photoelectrons emitted from the photocathode 24 a and the photoelectron 24 a that emits photoelectrons according to the number of incident photons. (Hereinafter, referred to as APD 24b) in the vacuum housing 24c.
- APD 24b a negative high voltage (for example, ⁇ 8 kV) is applied to the photocathode 24 a by the high-voltage power supply 24 d, and a reverse voltage is applied between the anode of the APD 24 b and the power source by the bias circuit 24 e.
- a bias voltage for example, +150 V
- the HPD 24 is provided with an electron lens unit (not shown) so that the photoelectrons emitted from the photocathode 24a can be efficiently incident on the APD 24b.
- an electron lens unit not shown
- photoelectrons corresponding to the number of incident photons are emitted from the photocathode 24a.
- the photoelectrons are accelerated by the action of the electric field, converged by the action of the electron lens, and enter the APD 24b.
- Photoelectrons incident on the APD 24 b generate a large number of hole-electron pairs when they lose their energy, and this is the first-stage multiplication factor.
- the first stage multiplication factor depends on the electron acceleration voltage (voltage applied to the photocathode), and is about 1200 when the voltage is 18 kV. After that, the electron avalanche multiplies about 50 times. As a result, a gain of about 60,000 times is obtained for the entire APD 24b.
- the multiplication fluctuation of the HPD 24 using the APD 24b is extremely small because the multiplication factor of the first stage is as large as about 1200. Therefore, the HPD 24 has an output wave height distribution characteristic for a multiphoton as shown in FIG. 2 (a). For this reason, the HPD 24 can distinguish and detect the number of incident photons.
- FIG. 2 (a) shows the measurement using an Oltec model number 142A preamplifier with the applied voltage of the photocathode 24a at 18 kV and the reverse bias voltage of the APD 24b at +150 V.
- the result Considering that the HPD 24 gain is about 60000 and that the half-width (FWHM) of the output waveform corresponding to one electron from the HPD 24 is about 2 ns, the output from the HPD 24 is The peak current is about 5 A per photon (for simplicity, the photo-electron conversion efficiency is 100%).
- the TZ amplifier 26 is a current-voltage conversion circuit that amplifies the current signal output from the APD 24b of the HPD 24, converts the signal into a voltage, and outputs the voltage. You. As shown in FIG. 2 (b), the output waveform of the TZ amplifier 26 has a constant time from 0 V to the maximum voltage value regardless of the magnitude of the incident signal.
- the TZ amplifier 26 preferably has an amplification factor of amplifying 18 to about 50111 and preferably has a band of about 300 MHz. For example, AU-1494-300 (trade name) of Miteq, etc. It is suitable.
- the peak value of the voltage output from the TZ amplifier 26 is about 0.25 V per photon due to the above amplification factor.
- the peak hold circuit 28 holds and outputs the peak value of the output signal from the TZ amplifier 26 for a certain period.
- the peak value output from the peak hold circuit 28 is reset by receiving a reset signal from the time signal output unit 14.
- the AZD converter 30 receives the trigger signal from the storage unit 16 and A / D converts the signal output from the peak hold circuit 28 and outputs the signal. At that time, the resolution is adjusted so that the number of incident photons is output as a digital value. More specifically, the input range (0 to 1V) is divided into four gradations, and when the input voltage is 0.125V to 0.375V, the digital value is "1" and the input voltage is 0.375V. Digital value "2" for up to 0.625 V, digital value "3" for input voltage 0.625 V to 0.875 V, digital for input voltage over 0.875 V Outputs the value "4".
- the digital value "1" when one photon is incident on the HPD 24, the digital value “2” when two photons are incident, and the digital value "2" when three photons are incident Is a digital value "3", and a digital value "4" is output from the A / D converter 30 when four photons are incident.
- the time signal output section 14 includes a timer 32 and a counter 34.
- the evening timer 32 generates and outputs a pulse signal at regular intervals (for example, 5 ns).
- the counter 34 receives a pulse signal from the timer 32 and A reset signal (reset signal A in FIG. 1) is output to the peak hold circuit 28 at regular intervals (for example, 5 ns).
- the counter 34 counts the pulse signal received from the timer 32, and outputs the count value multiplied by the period of the pulse signal (for example, 5 ns) to the storage section 16 as a time signal.
- the period of the pulse signal generated by the timer 32 is preferably as short as possible to improve the accuracy in determining the time resolution of the optical measuring device 10, but from the HPD 24 It is preferable that the time width is longer than the time width of the response waveform of one photon output. This is because if the pulse signal period is shorter than the one-photon response waveform, one event may be measured multiple times.
- the counter 34 is reset by a reset signal (reset signal B in FIG. 1) from the CPU 18 at the start of measurement or the like.
- the storage unit 16 includes a comparator 36, an A / D converter delay circuit 37, and a memory 38.
- the output signal from the peak hold circuit 28 is input to the + input terminal of the comparator 36, and the reference voltage is input to one input terminal.
- the reference voltage is set to 0.13 V which is lower than the voltage (0.25 V) corresponding to one photon at the output of the peak hold circuit 28.
- the comparator 36 compares the output signal from the peak hold circuit 28 with a reference voltage and outputs a comparison logic result. That is, when the output signal from the peak hold circuit 28 becomes larger than the reference voltage, the output is raised to a high level. Also, when the output signal from the peak hold circuit 28 becomes smaller than the reference voltage, the output falls to a low level.
- the output of the comparator 36 is given a fixed delay amount Delayl by the A / D converter delay circuit 37, and then output to the AZD converter 30 and the memory 38 as a trigger signal.
- the delay amount Delayl given by the delay circuit 37 for the AZD converter is equal to the delay amount of the TZ amplifier 26. It is set to a value equal to or slightly greater than the time required for the output waveform to reach the peak voltage from OV (Fig. 2 (b)).
- the memory 38 stores the output signal output from the AZD converter 30 and the time signal output from the counter 34 at the timing when the trigger signal is received from the A / D converter delay circuit 37.
- the operation of the storage unit 16 having the above configuration is as follows. That is, while no photon is incident on the HPD 24, no trigger signal is output from the A / D converter delay circuit 37, so that data is not stored in the memory 38. On the other hand, when a photon enters the HPD 24, a trigger signal is output from the A / D converter delay circuit 37 to the AZD converter 30 and the memory 38. In this case, the number of photons is output from the A / D converter 30 as a digital value and stored in the memory 38, and the time signal output from the counter is also stored in the memory 38.
- 3 (a) to 3 (h) are timing charts showing the operation of the optical measuring device according to the present embodiment.
- a reset signal is output from the CPU 18 to the counter 34, and the counter 34 is reset. Also, with the reset of the counter 34, counting of the pulse signal received from the timer 32 is started.
- the output signal from the TZ amplifier 26 is detected by the peak hold circuit 28, and the detection result is output to the A / D converter 30 and the comparator 36 (third (c) Figure).
- the output signal from the TZ amplifier 26 reaches the peak value, this peak value is held for a certain period by the peak hold circuit 28 and continues to be output to the AZD converter 30 and the comparator 36 (third ( c) Figure).
- the delay amount Delayl is set to be equal to or slightly longer than the time required for the output waveform of the TZ amplifier 26 to reach the peak value from 0 V.
- the A / D converter 30 has approximately 0.75 V (equivalent to three photons) which is the peak value of the output signal of the TZ amplifier 26. Is entered ing. Therefore, as shown in FIG. 3 (f), the digital value "3" is output from the A / D converter 30.
- the trigger signal is also input from the A / D converter delay circuit 37 to the memory 38, the output value from the A / D converter 30 and the output signal shown in FIG.
- the time signal output from the counter 34 is stored in the memory 38. That is, the value of the time signal from the counter 34, which is input first after the trigger signal is input to the memory 38, is stored in the memory 38.
- a reset signal is output from the counter 34 to the peak hold circuit 28 at regular intervals (for example, 5 ns) as shown in FIG. 3 (e). Therefore, the output signal of the peak hold circuit 28 is reset at regular intervals (for example, 5 ns) as shown in FIG. 3 (c).
- the data stored in the memory 38 is the third ( h) As shown in the figure.
- the optical measurement device 10 of the present embodiment detects photons by the photon detection unit 12 that detects incident photons, the time signal output unit 14 that outputs a time signal, and the photon detection unit 12. It is mainly provided with a storage unit 16 for storing the time signal output from the time signal output unit 14.
- the photon detector 12 includes an HPD 24 having a photocathode 24a and an APD 24b, a TZ amplifier 26, a peak hold circuit 28, and an A / D converter 30.
- the storage unit 16 includes a counter 34, and the storage unit 16 includes a comparator 36, an A / D converter delay circuit 37, and a memory 38.
- the optical measurement device 10 stores the number of photons detected by the HPD 24 and the time signal output from the counter 34 in the memory 38 when the photons are detected by the HPD 24. When and how many photons came. " On the other hand, when no photons are detected by the HPD 24, no information is stored in the memory 38, and the amount of data stored is extremely small. Therefore, the capacity of the memory 38 can be effectively used, and “when and how many photons have come” can be measured over a long period of time.
- Fig. 4 (a) when photons are incident with a time-series distribution as shown in Fig. 4 (a), if you try to measure when and how many photons came using a digital oscilloscope, As shown in FIG. 4 (b), the output value is stored in the memory in 256-level (8-bit) data every Ins in the time axis direction, whereas the optical measurement according to the present embodiment is performed. If the device 10 is used, as shown in Fig. 4 (c), it is only necessary to store the number of photons of up to four gradations (2 bits) and the time information at that time in the memory only when the photons are incident. .
- the optical measurement device 10 when the optical measurement device 10 according to the present embodiment is used, when a measurement time is set to 150 s and a time resolution is set to 5 ns using a memory of 64 Mbytes, measurement is possible up to a maximum of 16 M events (photon incidence). , Can be recorded.
- the use of the external memory 20 enables longer-time measurement and recording.
- the number of incident photons is output as a digital value by the AZD converter 30, so that the signal output from the A / D converter 30 is stored in a memory.
- the data can be stored directly in the display unit 38, and can also be displayed directly on the display unit 22.
- the photoelectric surface 24 a By using the HPD 24 with the avalanche photodiode 24b and the avalanche photodiode 24b, it is possible to efficiently detect the number of photons incident simultaneously (or at a very close timing).
- the HPD 24 is used for the light detection unit.
- this may be a VL PC (Visua 1 Right Photon Counter) or the like.
- the VLPC consists of an arsenic-doped silicon substrate and a thin, non-doped layer epitaxially grown on the silicon substrate.
- avalanche multiplication occurs, and a gain of about 5 ⁇ 10 4 is obtained.
- the reason why such a high gain is obtained in the VL PC is that the band gap can be regarded as being equal to the ionization energy from the impurity level.
- the VLPC has such a high gain, similar to the HPD, it is possible to output it by distinguishing the number of incident photons.
- optical measurement device 10 according to the present embodiment, the following modified examples can be considered.
- the reset signal is not output from the counter 34 to the peak hold circuit 28, but the reset signal is output from the newly provided delay circuit 29 to the peak hold circuit 28.
- the trigger signal output from the A / D converter delay circuit 37 is input to the delay circuit 29.
- the input voltage of the comparator 36 becomes higher than the reference voltage, so that a trigger signal is output from the A / D converter delay circuit 37.
- the A / D conversion circuit 30 A / D converts the output signal from the peak hold circuit 28 and outputs the converted signal to the memory 38.
- the trigger signal is given a predetermined delay Delay2 by the delay circuit 29, and then is output to the peak hold circuit 28 as a reset signal. Therefore, the peak hold circuit 28 is reset after a predetermined time has elapsed after the trigger signal is output from the AZD converter delay circuit 37.
- FIG. 6 (a) to 6 (h) are evening timing charts showing the operation of the optical measurement device 50.
- FIG. The operation of the optical measuring device 50 is different from that of the optical measuring device 10 according to the above embodiment in that it corresponds to the generation of a trigger signal from the AZD converter delay circuit 37, that is, in response to the incidence of a photon.
- the peak hold circuit 28 is reset.
- the reset signal is obtained by delaying the trigger signal from the AZD converter delay circuit 37 by a fixed time Delay2 by the delay circuit 29, so that in terms of timing, the A / D conversion circuit 30 After the A / D conversion is performed, the peak hold circuit 28 is reset.
- the peak hold circuit 28 is reset.
- FIG. 7 is a configuration diagram of an optical measurement device 60 according to a second modification.
- the current signal output from the HPD 24 is converted into a voltage by the TZ amplifier 26, and an output signal in which the peak value is held for a certain period by the peak hold circuit 28.
- this may be a charge amplifier 40 with a reset function like the optical measurement device 60 according to the present modification.
- One input terminal of the charge amplifier 40 is grounded, the output current of the HPD 24 is input to the other input terminal, and the output terminal is connected to the input terminal of the AZD converter 30 and the + terminal of the comparator 36.
- Operational amplifier 40a connected to the side input terminal and the other input terminal of the operational amplifier 40a And a reset switch 40c connected in parallel with the capacitor 40b.
- the charge amplifier 40 integrates the amount of electric charge output from the HPD 24, outputs a voltage that is the result of the integration, and outputs a reset signal (reset signal A in FIG. 7) from the counter 34 to the reset switch 40. Reset when c is turned on.
- the comparator 36 compares the output voltage from the charge amplifier 40 with the reference voltage, and switches the logic output to a high level when the output voltage becomes higher than the reference voltage. Switch output to mouth-to-mouth level. This high-level logic output is output as a trigger signal.
- the counter 34 of the time signal output unit 14 reads the read signal immediately before outputting the reset signal. (Read signal C in Fig. 7) (Figs. 8 (b) and 8 (c)).
- an AND circuit 42 is provided downstream of the comparator 36 in the storage unit 16.
- the read signal output from the counter 34 and the trigger signal (FIG. 8 (e)) output from the comparator 36 are input to the AND circuit 42.
- the output signal of the AND circuit is A It is output to the / D converter 30 and the memory 38. Therefore, in the optical measuring device 60, when the read signal is output from the counter 34 after the output voltage (FIG. 8 (d)) from the charge amplifier 40 exceeds the reference voltage, the AZD conversion circuit A / D conversion is performed by 30, and the output signal from the AZD conversion circuit 30 and the time signal from the counter 34 are stored in the memory 38. With this configuration, the peak hold circuit 28 and the A / D converter delay circuit 37 are not required. In addition, when multiple photons enter continuously in a short time, Even in this case, it is possible to minimize errors.
- the count 34 was reset by the reset signal from the CPU 18 at the start of the measurement.
- the counter 34 may be reset by a trigger signal of the A / D converter delay circuit 37. With this configuration, the counter 34 is reset with the incidence of photons, and the time signal output from the counter 34 indicates the interval at which the photons have entered the HPD 24. . Therefore, by adopting such a configuration, the memory 38 stores the number of photons incident on the HPD 24 and the incident interval of the photons.
- the APD 24b is used as the semiconductor light detector, but this may be a photodiode or the like.
- optical measurement device and the optical measurement method according to the present invention are not limited to the above-described embodiments and modified examples, and various modifications are possible.
- the value of the time signal from the counter 34 which is input first after the trigger signal is input to the memory 38, is stored in the memory 38.
- the value of the time signal from the counter 34 input last before the trigger signal is input to the memory 38 may be stored in the memory 38.
- optical measurement device and the optical measurement method according to the present invention are widely used for detecting bioluminescence and the like.
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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PCT/JP2000/006562 WO2002027284A1 (fr) | 2000-09-25 | 2000-09-25 | Appareil et procede de mesure optique |
EP00962814A EP1329700A4 (en) | 2000-09-25 | 2000-09-25 | APPARATUS AND METHOD FOR OPTICAL MEASUREMENT |
AU2000274441A AU2000274441A1 (en) | 2000-09-25 | 2000-09-25 | Optical measurement apparatus and method for optical measurement |
US10/381,370 US6940589B1 (en) | 2000-09-25 | 2000-09-25 | Optical measurement apparatus and method for optical measurement |
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PCT/JP2000/006562 WO2002027284A1 (fr) | 2000-09-25 | 2000-09-25 | Appareil et procede de mesure optique |
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US (1) | US6940589B1 (ja) |
EP (1) | EP1329700A4 (ja) |
AU (1) | AU2000274441A1 (ja) |
WO (1) | WO2002027284A1 (ja) |
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GB2398118B (en) * | 2003-02-07 | 2006-03-15 | Imp College Innovations Ltd | Photon arrival time detection |
WO2004099865A2 (en) * | 2003-05-02 | 2004-11-18 | Massachusetts Institute Of Technology | Digital photon-counting geiger-mode avalanche photodiode solid-state monolithic intensity imaging focal-plane with scalable readout circuitry |
ITUD20050119A1 (it) * | 2005-07-18 | 2007-01-19 | Neuricam Spa | Elemento fotosensibile per sensori elettro-ottici |
WO2008054883A2 (en) * | 2006-06-07 | 2008-05-08 | Xrf Corporation | Devices and methods for detecting and analyzing radiation |
CA2673386A1 (en) * | 2006-12-22 | 2008-07-03 | Washington University | High performance imaging system for diffuse optical tomography and associated method of use |
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JP5494063B2 (ja) * | 2010-03-17 | 2014-05-14 | コニカミノルタ株式会社 | 制御装置及び画像形成装置 |
CN106052861B (zh) * | 2016-07-27 | 2017-08-29 | 武汉京邦科技有限公司 | 一种硅光电倍增器测试系统及测试方法 |
FR3058230B1 (fr) * | 2016-10-27 | 2019-03-15 | Detection Technology Sas | Dispositif de spectrometrie |
CN106949979A (zh) * | 2017-02-09 | 2017-07-14 | 北京建筑大学 | 一种基于lc振荡电路的光速测量方法 |
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- 2000-09-25 EP EP00962814A patent/EP1329700A4/en not_active Withdrawn
- 2000-09-25 WO PCT/JP2000/006562 patent/WO2002027284A1/ja active Application Filing
- 2000-09-25 AU AU2000274441A patent/AU2000274441A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
EP1329700A1 (en) | 2003-07-23 |
US6940589B1 (en) | 2005-09-06 |
EP1329700A4 (en) | 2011-03-23 |
AU2000274441A1 (en) | 2002-04-08 |
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