WO2001077384A3 - DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN - Google Patents

DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN Download PDF

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Publication number
WO2001077384A3
WO2001077384A3 PCT/IB2001/000713 IB0100713W WO0177384A3 WO 2001077384 A3 WO2001077384 A3 WO 2001077384A3 IB 0100713 W IB0100713 W IB 0100713W WO 0177384 A3 WO0177384 A3 WO 0177384A3
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WO
WIPO (PCT)
Prior art keywords
snp
single nucleotide
nucleotide polymorphisms
methylations
cytosine
Prior art date
Application number
PCT/IB2001/000713
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English (en)
French (fr)
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WO2001077384A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
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Filing date
Publication date
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to AU2001250572A priority Critical patent/AU2001250572A1/en
Priority to US10/257,017 priority patent/US20040241651A1/en
Priority to EP01923891A priority patent/EP1268856A2/de
Publication of WO2001077384A2 publication Critical patent/WO2001077384A2/de
Publication of WO2001077384A3 publication Critical patent/WO2001077384A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Beschrieben wird ein Satz von Oligonukleotiden oder PNA-Oligomeren und ein Verfahren, das sich zur Detektion von Cytosin-Methylierungen und SNPs in genomischen DNA-Proben eignet. Dieses Verfahren dient der Diagnose und/oder Prognose nachteiliger Ereignisse für Patienten oder Individuen, wie Erkrankungen.
PCT/IB2001/000713 2000-04-07 2001-04-06 DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN WO2001077384A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001250572A AU2001250572A1 (en) 2000-04-07 2001-04-06 Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
US10/257,017 US20040241651A1 (en) 2000-04-07 2001-04-06 Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
EP01923891A EP1268856A2 (de) 2000-04-07 2001-04-06 Detektion von snp's und cytosin-methylierungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019173.8 2000-04-07
DE10019173 2000-04-07

Publications (2)

Publication Number Publication Date
WO2001077384A2 WO2001077384A2 (de) 2001-10-18
WO2001077384A3 true WO2001077384A3 (de) 2002-07-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/000713 WO2001077384A2 (de) 2000-04-07 2001-04-06 DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN

Country Status (4)

Country Link
US (1) US20040241651A1 (de)
EP (1) EP1268856A2 (de)
AU (1) AU2001250572A1 (de)
WO (1) WO2001077384A2 (de)

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