WO2002036814A3 - Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4 - Google Patents

Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4 Download PDF

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Publication number
WO2002036814A3
WO2002036814A3 PCT/EP2001/012827 EP0112827W WO0236814A3 WO 2002036814 A3 WO2002036814 A3 WO 2002036814A3 EP 0112827 W EP0112827 W EP 0112827W WO 0236814 A3 WO0236814 A3 WO 0236814A3
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WO
WIPO (PCT)
Prior art keywords
cdk4
determining
diagnosis
diseases associated
methylation state
Prior art date
Application number
PCT/EP2001/012827
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English (en)
French (fr)
Other versions
WO2002036814A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to EP01992793A priority Critical patent/EP1332228A2/de
Priority to US10/416,110 priority patent/US20040072198A1/en
Priority to AU2002218283A priority patent/AU2002218283A1/en
Publication of WO2002036814A2 publication Critical patent/WO2002036814A2/de
Publication of WO2002036814A3 publication Critical patent/WO2002036814A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Die vorliegende Erfindung betrifft die chemisch modifizierte genomische Sequenz des Cdk4 Gens, gegen die Sequenz gerichtete Oligonukleotide und/oder PNA-Oligomere zur Detektion des Cytosin-Methylierungszustandes des Cdk4 Gens, sowie ein Verfahren zur Ermittlung von genetischen und/oder epigenetischen Parametern des Cdk4-Gens.
PCT/EP2001/012827 2000-11-06 2001-11-06 Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4 WO2002036814A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01992793A EP1332228A2 (de) 2000-11-06 2001-11-06 Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4 gens
US10/416,110 US20040072198A1 (en) 2000-11-06 2001-11-06 Diagnosis of diseases associated with cdk4
AU2002218283A AU2002218283A1 (en) 2000-11-06 2001-11-06 Diagnosis of diseases associated with cdk4 by determining the methyl delivery state of cdk4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054974A DE10054974A1 (de) 2000-11-06 2000-11-06 Diagnose von mit Cdk4 assoziierten Krankheiten
DE10054974.8 2000-11-06

Publications (2)

Publication Number Publication Date
WO2002036814A2 WO2002036814A2 (de) 2002-05-10
WO2002036814A3 true WO2002036814A3 (de) 2003-04-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012827 WO2002036814A2 (de) 2000-11-06 2001-11-06 Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4

Country Status (5)

Country Link
US (1) US20040072198A1 (de)
EP (1) EP1332228A2 (de)
AU (1) AU2002218283A1 (de)
DE (1) DE10054974A1 (de)
WO (1) WO2002036814A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370685A2 (de) 2000-04-06 2003-12-17 Epigenomics AG Diagnose von dns-reparatur assozierten krankheiten
EP1410304A2 (de) * 2001-03-26 2004-04-21 Epigenomics AG Verfahren zur epigenetischen merkmalauswahl
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
DE10255104A1 (de) * 2002-08-27 2004-03-11 Epigenomics Ag Verfahren und Nukleinsäuren für die Analyse von proliferativen Erkrankungen von Brustzellen
DE10245779A1 (de) * 2002-10-01 2004-04-29 Epigenomics Ag Verfahren und Nukleinsäuren für die verbesserte Behandlung von proliferativen Erkrankungen von Brustzellen
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
DK1871912T3 (da) 2005-04-15 2012-05-14 Epigenomics Ag Fremgangsmåde til bestemmelse af DNA-methylering i blod- eller urinprøver
DE102014108935B4 (de) 2013-09-06 2016-09-08 Westfalia Presstechnik Gmbh & Co. Kg Abdeckung für eine Bremse oder einen Bereich einer Bremse oder ein Rad eines Fahrzeuges, insbesondere Bremsabdeckblech
EP2848327A1 (de) 2013-09-06 2015-03-18 Westfalia Presstechnik GmbH & Co. KG Flächenelement, insbesondere für ein Kraftfahrzeug
DE202014104211U1 (de) 2014-09-06 2015-12-09 Westfalia Presstechnik Gmbh & Co. Kg Flächenelement, insbesondere für ein Kraftfahrzeug

Citations (7)

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US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
WO2000031238A2 (en) * 1998-11-25 2000-06-02 Genetica, Inc. Methods and reagents for increasing proliferative capacity and preventing replicative senescence
WO2001068911A2 (en) * 2000-03-15 2001-09-20 Epigenomics Ag Diagnosis of diseases associated with the cell cycle
WO2002000928A2 (de) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung

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US4962020A (en) * 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
US5869462A (en) * 1992-09-10 1999-02-09 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of proliferation of vascular smooth muscle cell
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WO1999027087A1 (en) * 1997-11-21 1999-06-03 Hybridon, Inc. Antisense oligonucleotides specific for cdk4
AU766544B2 (en) * 1998-06-06 2003-10-16 Genostic Pharma Limited Probes used for genetic profiling
AU4158799A (en) * 1998-06-06 1999-12-30 Genostic Pharma Limited Probes used for genetic filing
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
EP1502222A2 (de) * 2001-07-02 2005-02-02 Epigenomics AG Verteiltes system zur epigenetisch-basierten vorhersagung von komplexen phänotypen

Patent Citations (8)

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US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
WO2000031238A2 (en) * 1998-11-25 2000-06-02 Genetica, Inc. Methods and reagents for increasing proliferative capacity and preventing replicative senescence
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
WO2001068911A2 (en) * 2000-03-15 2001-09-20 Epigenomics Ag Diagnosis of diseases associated with the cell cycle
WO2002000928A2 (de) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung
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DATABASE EMBL [online] EBI; 12 September 2000 (2000-09-12), HANNON GJ ET AL.: "Cyclin-dependent kinase 4 genomic DNA", XP002215734, retrieved from HTTP://WWW.EBI.AC.UK/CGI-BIN/EMBLFETCH Database accession no. aaa29390 *
DATABASE EMBL [online] EBI; 23 March 2000 (2000-03-23), MUZNY D.M. ET AL.: "Homo sapiens chromosome 12 clone RP11-534N15", XP002215733, retrieved from HTTP://WWW.EBI.AC.UK/CGI-BIN/EMBLFETCH Database accession no. AC026340 *
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DATABASE GENBANK [online] NCBI; 5 June 1996 (1996-06-05), ZUO L. ET AL.: "Human cyclin-dependent kinase 4(CDK4) gene", XP002197856, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ Database accession no. U37022 *
NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249 *
REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048 *
See also references of EP1332228A2 *
WUNDER JS: "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas", ONCOGENE, vol. 18, no. 3, 21 January 1999 (1999-01-21), pages 783 - 788, XP001070963 *
ZUO L. ET AL.: "Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma", NATURE GENETETICS, vol. 12, no. 1, 1996, pages 97 - 99, XP002069633 *

Also Published As

Publication number Publication date
EP1332228A2 (de) 2003-08-06
WO2002036814A2 (de) 2002-05-10
AU2002218283A1 (en) 2002-05-15
US20040072198A1 (en) 2004-04-15
DE10054974A1 (de) 2002-06-06

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